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4625494 Method and apparatus for making mixtures of pharmaceutical liquids
iv
New Patents
(I) See Patent for Chemical Structure (I) wherein R 1 and R2 each independently represents hydrogen, hydroxyl or alkoxy having from 1 to 6 carbon atoms, X is oxygen and Z is a double bondCH2 or double bondCH-COOR3 group, in which R3 is hydrogen or alkyl having from 1 to 6 carbon atoms; or X represents an double bondNR4 group, in which R4 is hydrogen or hydroxyl, and Z is a double bondCH-CN, double bondCH2 or double bondCH-COOR3 group, in which R3 is as defined above, and acid addition salts thereof. The compounds of formula (I) are pharmaceutically active, in particular show antispasm, analgesic, gastric acid secretion inhibiting, sedative and hypnotic activity and effectively reduce the alcoholic narcosis time. According to a further aspect of the invention there is provided a process for the preparation of these compounds. The invention further relates to pharmaceutical compositions containing them as active ingredient.
4622336 3,3-DIALKYL-AND 3,3-ALKYLENEINDOLINE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM Roland Achini, Therwil, Switzerland assigned to Sandoz Ltd 3,3-Dialkyl- or 3,3-alkylene-indolines which are unsubstituted at the 1- and 2-positions and which are substituted at the 4- or 6-position by an optionally etherified hydroxy group or substituted at the 5- or 7-position by an etherified hydroxy group, as well as their physiologicallyhydrolyzable and -acceptable esters. The said indolines and esters as well as their pharmaceutically acceptable acid addition salts possess analgesic activity.
4622430 DERIVATIVES OF PENTACYCLO UNDECANES, PROCESSES FOR PREPARING THESE COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS THEREOF Theodor G Dekker, Douglas W Oliver, Friedrich O Snyckers, Schyf Cornelis van der,
Pretoria, South Africa assigned to Noristan Limited Pentacyclo(6.3.0.0.2,6.03,10.05,9)undecane and its derivatives are prepared. The compounds find use as antiviral agents.
4625494 METHOD AND APPARATUS FOR MAKING MIXTURES OF PHARMACEUTICAL LIQUIDS Peter Iwatschenko, Fritz Giebler, Neunkirchen, Federal Republic Of Germany assigned to Pfrimmer & Co Pharmazeutische Werke Erlangen Method for the preparation of mixtures of pharmaceutical liquids, for example infusion solutions, from storage containers containing at least two of the individual mixture components, in an arrangement with a vacuum chamber to receive the containers to be filled and with a connecting hose for each storage container as well as a tube connected to the container to be filled and also connected with the connection hoses of the storage containers via a hose connection, with the attainment of the desired predetermined amount of each mixture component being indicated by registering air intake into the individual connection hoses, clamping the respective connecting tube and sealing and cutting the hose downstream from the clamping following corresponding registration of air intake into all present connection hoses.
4628050 ANTINEPHRITIC PHARMACEUTICAL COMPOSITION CONTAINING 24, 25DIHYDROXYCHOLECALCIFEROL AS AN ACTIVE INGREDIENT Yuji Maeda, Hideyuki Yamato, Takayoshi Fujii, Yasuhiko Kobayashi, Kenichi Saito, Tadaaki Kato, Chikao Yoshikumi, Nagareyama, Japan assigned to Kureha Kagaku Kogyo Kabushiki Kaisha Disclosed herein is a pharmaceutical composition in dosage unit form, which comprises a dosage effective for treating nephritic disease of a compound of 24,25-dihydroxycholecalciferol
New Patents
(I) See Patent for Chemical Structure (I) wherein R 1 and R2 each independently represents hydrogen, hydroxyl or alkoxy having from 1 to 6 carbon atoms, X is oxygen and Z is a double bondCH2 or double bondCH-COOR3 group, in which R3 is hydrogen or alkyl having from 1 to 6 carbon atoms; or X represents an double bondNR4 group, in which R4 is hydrogen or hydroxyl, and Z is a double bondCH-CN, double bondCH2 or double bondCH-COOR3 group, in which R3 is as defined above, and acid addition salts thereof. The compounds of formula (I) are pharmaceutically active, in particular show antispasm, analgesic, gastric acid secretion inhibiting, sedative and hypnotic activity and effectively reduce the alcoholic narcosis time. According to a further aspect of the invention there is provided a process for the preparation of these compounds. The invention further relates to pharmaceutical compositions containing them as active ingredient.
4622336 3,3-DIALKYL-AND 3,3-ALKYLENEINDOLINE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM Roland Achini, Therwil, Switzerland assigned to Sandoz Ltd 3,3-Dialkyl- or 3,3-alkylene-indolines which are unsubstituted at the 1- and 2-positions and which are substituted at the 4- or 6-position by an optionally etherified hydroxy group or substituted at the 5- or 7-position by an etherified hydroxy group, as well as their physiologicallyhydrolyzable and -acceptable esters. The said indolines and esters as well as their pharmaceutically acceptable acid addition salts possess analgesic activity.
4622430 DERIVATIVES OF PENTACYCLO UNDECANES, PROCESSES FOR PREPARING THESE COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS THEREOF Theodor G Dekker, Douglas W Oliver, Friedrich O Snyckers, Schyf Cornelis van der,
Pretoria, South Africa assigned to Noristan Limited Pentacyclo(6.3.0.0.2,6.03,10.05,9)undecane and its derivatives are prepared. The compounds find use as antiviral agents.
4625494 METHOD AND APPARATUS FOR MAKING MIXTURES OF PHARMACEUTICAL LIQUIDS Peter Iwatschenko, Fritz Giebler, Neunkirchen, Federal Republic Of Germany assigned to Pfrimmer & Co Pharmazeutische Werke Erlangen Method for the preparation of mixtures of pharmaceutical liquids, for example infusion solutions, from storage containers containing at least two of the individual mixture components, in an arrangement with a vacuum chamber to receive the containers to be filled and with a connecting hose for each storage container as well as a tube connected to the container to be filled and also connected with the connection hoses of the storage containers via a hose connection, with the attainment of the desired predetermined amount of each mixture component being indicated by registering air intake into the individual connection hoses, clamping the respective connecting tube and sealing and cutting the hose downstream from the clamping following corresponding registration of air intake into all present connection hoses.
4628050 ANTINEPHRITIC PHARMACEUTICAL COMPOSITION CONTAINING 24, 25DIHYDROXYCHOLECALCIFEROL AS AN ACTIVE INGREDIENT Yuji Maeda, Hideyuki Yamato, Takayoshi Fujii, Yasuhiko Kobayashi, Kenichi Saito, Tadaaki Kato, Chikao Yoshikumi, Nagareyama, Japan assigned to Kureha Kagaku Kogyo Kabushiki Kaisha Disclosed herein is a pharmaceutical composition in dosage unit form, which comprises a dosage effective for treating nephritic disease of a compound of 24,25-dihydroxycholecalciferol