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472 EXPRESSION OF THE GENE ENCODING OXALATE DECARBOXYLASE FROM BACILLUS SUBTILIS AND PURIFICATION OF THE RECOMBINANT ENZYME
470
473
HYPERCALCIURIA IN IDIOPATHIC CALCIUM NEPHROLITHIASIS: AN ACID-BASE METABOLIC DISORDER?
2VWKHU3-6 Fredericia Hospital, Dept. of Urology, Fredericia, Denmark Introduction & Objectives: +\SHUFDOFLXULD LQ UHQDO VWRQH IRUPHUV LV XVXDOO\ LGLRSDWKLFLQWKHVHQVHWKDWPRVWSDWLHQWVDUHQRUPRFDOFDHPLFZLWKRXWDQ\REYLRXV FDXVH RI WKH LQFUHDVHG FDOFLXP H[FUHWLRQ DQG DOWKRXJK DGGUHVVHG LQ VHYHUDO VWXGLHV WKH H[DFW DHWLRORJ\ RI K\SHUFDOFLXULD LQ FDOFLXP QHSKUROLWKLDVLV UHPDLQV GHEDWDEOH,WLVNQRZQWKDWDಫZHVWHUQಬGLHWUHVXOWVLQDQDFLGORDGDQGWKHDLPRI WKLVVWXG\ZDVWRHYDOXDWHWKHUROHRIDFLGEDVHPHWDEROLVP Material & Methods: FRQVHFXWLYH PDOH UHFXUUHQW LGLRSDWKLF FDOFLXP VWRQH IRUPHUV DQG KHDOWK\ PDOHV PDWFKHG IRU DJH DQG %0, ZHUH LQFOXGHG LQ WKH VWXG\ K XULQHV ZHUH VDPSOHG ZLWKRXW GLHWDU\ UHVWULFWLRQV $ VXEJURXS RI VWRQH IRUPHUVZLWKK\SHUFDOFLXULD GHᚏQHGDV&D 8 K PPRONJERG\ PDVV DQGKHDOWK\PDOHVZHUHIXUWKHUHYDOXDWHGE\1+&OORDGLQJVWXGLHVLQDGRXEOH EOLQGUDQGRPL]HGSODFHERFRQWUROOHGFURVVRYHUGHVLJQ6HUXPLRQL]HGFDOFLXPDQG UDWHVRIUHQDOFDOFLXPDQGQRQPHWDEROL]DEOHDFLG 1$ H[FUHWLRQZHUHPHDVXUHG KRXUO\ Results: 7KHFXPXODWLYHIUHTXHQF\GLVWULEXWLRQFXUYHIRUKXULQDU\H[FUHWLRQRI FDOFLXPFOHDUO\VKRZHGWKDWWKHVWRQHIRUPHUVDQGWKHKHDOWK\FRQWUROVSUHVHQWHG DV GLVWLQFWO\ GLᚎHUHQW SRSXODWLRQV ZLWK VLJQLᚏFDQWO\ KLJKHU H[FUHWLRQ OHYHOV LQ WKH VWRQHIRUPHUV S ,RQL]HGFDOFLXPLQVHUXPLQFUHDVHGVLJQLᚏFDQWO\LQERWK JURXSV LQ UHVSRQVH WR DFLG ORDGLQJ FRPSDUHG WR SODFHER S KRZHYHU ZLWKVLJQLᚏFDQWO\KLJKHUOHYHOVLQWKHVWRQHIRUPHUV S 'XULQJDFLGORDGLQJ XULQDU\ FDOFLXP H[FUHWLRQ LQFUHDVHG PDUNHGO\ LQ ERWK JURXSV ZLWK VLJQLᚏFDQWO\ KLJKHU H[FUHWLRQ UDWHV LQ WKH VWRQH IRUPHUV S $OVR IUDFWLRQDO H[FUHWLRQ RI FDOFLXPLQXULQHZDVKLJKHULQWKHVWRQHIRUPHUV S )XUWKHUPRUHWKHVWRQH IRUPHUVH[FUHWHGVLJQLᚏFDQWO\PRUHFDOFLXPLQWKHXULQHDWDJLYHQUDWHRIUHQDO1$ H[FUHWLRQ Conclusions: $VDJURXSUHFXUUHQWLGLRSDWKLFFDOFLXPVWRQHIRUPHUVKDGKLJKHU XULQDU\ FDOFLXP H[FUHWLRQ UDWHV WKDQ PDWFKHG KHDOWK\ FRQWUROV :LWK UHJDUG WR FDOFLXPPHWDEROLVPUHFXUUHQWLGLRSDWKLFFDOFLXPVWRQHIRUPHUVVHHPWREHPRUH VHQVLWLYHWRDQDFLGORDGWKDQKHDOWK\VXEMHFWV7KHPRVWREYLRXVH[SODQDWLRQLV WKDWWKHVWRQHIRUPHUVH[SHULHQFHGDKLJKHUGHJUHHRIERQHEXᚎHULQJGXULQJDFLG ORDGLQJ7KLVPHFKDQLVPPD\H[SODLQZK\FDOFLXPVWRQHIRUPHUVIUHTXHQWO\KDYH PRGHUDWHERQHPLQHUDOL]DWLRQGHIHFWVDQGLWPD\EHDVLJQLᚏFDQWSDWKRSK\VLRORJLFDO IDFWRUH[SODLQLQJZK\WKHVHLQGLYLGXDOVIRUPFDOFLXPFRQWDLQLQJUHQDOVWRQHV
471
WITHDRAWN
472
EXPRESSION OF THE GENE ENCODING OXALATE DECARBOXYLASE FROM BACILLUS SUBTILIS AND PURIFICATION OF THE RECOMBINANT ENZYME
/HH(3DUN<+-HRQJ%&/HH6%.X-+-HRQJ+.ZDN& .LP++ 1 Seoul National University, Dept. of Urology, Seoul, South Korea, 2Sungkyunkwan University, Dept. of Urology, Seoul, South Korea Introduction & Objectives: 7KH%DFLOOXVVXEWLOLVR[DODWHGHFDUER[\ODVHFRQYHUWV R[DODWHWRIRUPDWDQG&27KHDLPRIWKLVVWXG\ZDVWRSXULI\WKHUHFRPELQDQW R[DODWH GHFDUER[\ODVH 2;'& RYHU H[SUHVVHG LQ (VFKHULFKLD FROL DQG HYDOXDWH WKHR[DODWHGHJUDGLQJDFWLYLW\RISXULᚏHG2;'& Material & Methods:
COMPARISON OF PLASMA, CELLULAR AND URINARY OXALATE IN PRIMARY CALCIUM OXALATE MONOHYDRATE STONE FORMERS VS. RECURRENT CALCIUM OXALATE MONOHYDRATE STONE FORMERS
2HKOVFKO¦JHU6)XHVVHO6+HUUPDQQ-/RW]NDW8$OEUHFKW6:LUWK03 1 Technical University of Dresden, Dept. of Urology, Dresden, Germany, 2Technical University of Dresden, Dept. of Gynaecology, Dresden, Germany Introduction & Objectives: 3DWKRORJLFR[DODWHWUDQVSRUWLQKXPDQLVLQWHJUDWHG LQ FDOFLXP R[DODWH VWRQH IRUPDWLRQ 7R YHULI\ SULPDU\ IURP UHFXUUHQW VWRQH IRUPHUVPHDVXUHPHQWVRIXULQDU\SDUDPHWHUVRIWHQIDLO:HH[DPLQHGWKHR[DODWH FRQFHQWUDWLRQLQSODVPDHU\WKURF\WHFHOOVXULQHWKHHU\WKURF\WHR[DODWHLQᚐX[ S+ DQG WKH EDQG ,,, WUDQVSRUW SURWHLQ OHYHOV WR FRPSDUH SULPDU\ S&20 YV UHFXUUHQWFDOFLXPR[DODWHPRQRK\GUDWHVWRQHIRUPHUV U&20 Material & Methods: S&20DQGU&20ZHUHVWXGLHGEHWZHHQ6HSW DQG6HSW7KHPHDQDJHDQGWKHPHQZRPHQUDWLRLQS&20YVU&20ZHUH s\HDUVYV s\HDUVDQG YV2EHVLW\K\SHUWHQVLRQDQGGLDEHWHV PHOOLWXVRFFXULQS&20 YVU&20 %ORRG IURP ZDV GUDZQ LQWR D PO DPPRQLDF KHSDULQDW PRQRYHWWH WKH HU\WKURF\WHV ZHUHLVRODWHG7KHHU\WKURF\WHVZHUHGLYLGHGIRUFHOOXODUR[DODWHPHDVXUHPHQWDQG IRUUHVXVSHQWLRQLQS+YDOXHEXᚎHUHGVROXWLRQPPROOR[DODWHZDVDGGHG 0HDVXUHPHQWVRIVXSHUQDWDQWVR[DODWHDQGS+YDOXHZHUHGRQHLPPHGLDWHO\DQG RQH KRXU DIWHU LQFXEDWLRQ WR FDOFXODWH WUDQVPHPEUDQH HU\WKURF\WH R[DODWH ᚐX[ GLᚎHUHQFHRIS+YDOXH7KHHU\WKURF\WHEDQG,,,WUDQVSRUWSURWHLQ 6/&D ZDV GHWHUPLQHGZLWK:HVWHUQ%ORWDQDO\VHV %DQG,,,DQWLERG\*$3'+DVUHIHUHQFH $GGLWLRQDOO\ SODVPD DQG XULQDU\ R[DODWH FRQFHQWUDWLRQ IURP D VLQJOH XULQH VSRW ZHUH DQDO\VHG 6WDWLVWLF DQDO\VHV ZHUH GRQH XVLQJ 87HVW 0DQQ:KLWQH\ DQG 6SHDUPDQFRUUHODWLRQVFRHᚑFLHQW Results: 7KH PHDQ FHOOXODU R[DODWH FRQFHQWUDWLRQV ZHUH VLJQLᚏFDQWO\ ORZHU LQ U&20 VWRQH IRUPHUV S 7KH FHOOXODU R[DODWH FRUUHODWHG ZLWK HU\WKURF\WH R[DODWHLQᚐX[S+SODVPDR[DODWHDQGGLDEHWHV U U LQU&20 3HUFHQWDJHRI &20VWRQH 3ODVPDR[DODWH wPROO &HOOXODUR[DODWH wPROO EDQG,,,WUDQVSRUW SURWHLQ5%& (U\WKURF\WH R[DODWHLQᚐX[S+ wPROO K XULQDU\R[DODWH *)5[ PPROO
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Conclusions: ,Q FRPSDULVRQ WR SULPDU\ FDOFLXP R[DODWH PRQRK\GUDWH VWRQH IRUPHUV S&20 VLJQLᚏFDQWO\ORZHUYDOXHVRIFHOOXODUR[DODWHLQUHFXUUHQWFDOFLXP R[DODWHPRQRK\GUDWHVWRQHIRUPHUV U&20 ZHUHDVVRFLDWHGZLWKR[DODWHWUDQVSRUW GHᚏFLHQF\DQGPHWDEROLFGLVRUGHUV
474
ERYTHROCYTE OXIDANT STRESS IN PATIENTS WITH UROLITHIASIS CORRELATES WITH STONE SIZE AND RENAL TUBULAR DAMAGE
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Introduction & Objectives: 2[LGDWLYHVWUHVVLVDVVRFLDWHGZLWKXUROLWKLDVLVDQGLV NQRZQWRIDYRXUGLVHDVHSURJUHVVLRQE\GHWHULRUDWLQJNLGQH\IXQFWLRQ&LUFXODWLQJ HU\WKURF\WHV DUH HTXLSSHG ZLWK D KLJKO\ HᚎHFWLYH DQWLR[LGDQW GHIHQFH IRU HQGRJHQRXVO\VFDYHQJLQJIUHHUDGLFDOV7KHDLPRIWKHVWXG\ZDVWRLQYHVWLJDWHWKH UHODWLRQVKLSEHWZHHQR[LGDWLYHVWUHVVELRPDUNHUVLQEORRGFHOOVDQGUHQDOWXEXODU GDPDJHZLWKWKHVL]HRIFDOFLXPR[DODWH &D2[ VWRQH Material & Methods: 7KLVVWXG\LQFOXGHG QRUPDOFRQWUROVXEMHFWV SDWLHQWV ZLWK NLGQH\ VWRQHV .6 DQG SDWLHQWV ZLWK XUHWHUDO VWRQHV 86 &D2[ VWRQH GHSRVLWLRQ FDXVHG E\ K\SHUR[DOXULD LQ WZR VWRQH JURXSV ZDV DVVRFLDWHG ZLWK LQFUHDVHG XULQDU\ H[FUHWLRQ RI R[DODWH PDORQGLDOGHK\GH DQG WXEXODU PDUNHU JOXWDWKLRQH6WUDQVIHUDVHDVZHOODVORZHUHGXULQDU\FLWUDWHH[FUHWLRQ(Q]\PDWLF DFWLYLW\ ZDV PHDVXUHG E\ WKH FRPPHUFLDO DYDLODEOH NLW 3URWHLQ H[SUHVVLRQ LQ HU\WKURF\WHRUOHXNRF\WHZDVH[DPLQHGE\:HVWHUQEORW Results: ,Q WKH HU\WKURF\WH DQWLR[LGDQW GHIHQFH DV WKH DPRXQW RI UHGXFHG JOXWDWKLRQH DQG WKH DFWLYLWLHV RI FDWDODVH DQG FRSSHU]LQFVXSHUR[LGH GLVPXWDVH ZHUH VLJQLᚏFDQWO\ GHFUHDVHG LQ ERWK VWRQH JURXSV ZKHQ FRPSDUHG WR FRQWURO 7KH DFWLYLWLHV RI JOXWDWKLRQH SHUR[LGDVH DQG JOXWDWKLRQH UHGXFWDVH ZHUH DOVR GHFUHDVHGLQWKH86JURXS&KDQJHVLQHU\WKURF\WHR[DODWHZHUHFRUUHODWHGZLWK PDORQGLDOGHK\GHSRVLWLYHO\DQGWKHDFWLYLW\RIDQWLR[LGDQWSURWHLQQHJDWLYHO\7RWHVW ZKHWKHUWKHFLUFXODWLQJOHXNRF\WHVLVDQRWKHUVRXUFHIRUIUHHUDGLFDOVJHQHUDWLRQ
Eur Urol Suppl 2010;9(2):167
473
HYPERCALCIURIA IN IDIOPATHIC CALCIUM NEPHROLITHIASIS: AN ACID-BASE METABOLIC DISORDER?
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471
WITHDRAWN
472
EXPRESSION OF THE GENE ENCODING OXALATE DECARBOXYLASE FROM BACILLUS SUBTILIS AND PURIFICATION OF THE RECOMBINANT ENZYME
/HH(3DUN<+-HRQJ%&/HH6%.X-+-HRQJ+.ZDN& .LP++ 1 Seoul National University, Dept. of Urology, Seoul, South Korea, 2Sungkyunkwan University, Dept. of Urology, Seoul, South Korea Introduction & Objectives: 7KH%DFLOOXVVXEWLOLVR[DODWHGHFDUER[\ODVHFRQYHUWV R[DODWHWRIRUPDWDQG&27KHDLPRIWKLVVWXG\ZDVWRSXULI\WKHUHFRPELQDQW R[DODWH GHFDUER[\ODVH 2;'& RYHU H[SUHVVHG LQ (VFKHULFKLD FROL DQG HYDOXDWH WKHR[DODWHGHJUDGLQJDFWLYLW\RISXULᚏHG2;'& Material & Methods:
COMPARISON OF PLASMA, CELLULAR AND URINARY OXALATE IN PRIMARY CALCIUM OXALATE MONOHYDRATE STONE FORMERS VS. RECURRENT CALCIUM OXALATE MONOHYDRATE STONE FORMERS
2HKOVFKO¦JHU6)XHVVHO6+HUUPDQQ-/RW]NDW8$OEUHFKW6:LUWK03 1 Technical University of Dresden, Dept. of Urology, Dresden, Germany, 2Technical University of Dresden, Dept. of Gynaecology, Dresden, Germany Introduction & Objectives: 3DWKRORJLFR[DODWHWUDQVSRUWLQKXPDQLVLQWHJUDWHG LQ FDOFLXP R[DODWH VWRQH IRUPDWLRQ 7R YHULI\ SULPDU\ IURP UHFXUUHQW VWRQH IRUPHUVPHDVXUHPHQWVRIXULQDU\SDUDPHWHUVRIWHQIDLO:HH[DPLQHGWKHR[DODWH FRQFHQWUDWLRQLQSODVPDHU\WKURF\WHFHOOVXULQHWKHHU\WKURF\WHR[DODWHLQᚐX[ S+ DQG WKH EDQG ,,, WUDQVSRUW SURWHLQ OHYHOV WR FRPSDUH SULPDU\ S&20 YV UHFXUUHQWFDOFLXPR[DODWHPRQRK\GUDWHVWRQHIRUPHUV U&20 Material & Methods: S&20DQGU&20ZHUHVWXGLHGEHWZHHQ6HSW DQG6HSW7KHPHDQDJHDQGWKHPHQZRPHQUDWLRLQS&20YVU&20ZHUH s\HDUVYV s\HDUVDQG YV2EHVLW\K\SHUWHQVLRQDQGGLDEHWHV PHOOLWXVRFFXULQS&20 YVU&20 %ORRG IURP ZDV GUDZQ LQWR D PO DPPRQLDF KHSDULQDW PRQRYHWWH WKH HU\WKURF\WHV ZHUHLVRODWHG7KHHU\WKURF\WHVZHUHGLYLGHGIRUFHOOXODUR[DODWHPHDVXUHPHQWDQG IRUUHVXVSHQWLRQLQS+YDOXHEXᚎHUHGVROXWLRQPPROOR[DODWHZDVDGGHG 0HDVXUHPHQWVRIVXSHUQDWDQWVR[DODWHDQGS+YDOXHZHUHGRQHLPPHGLDWHO\DQG RQH KRXU DIWHU LQFXEDWLRQ WR FDOFXODWH WUDQVPHPEUDQH HU\WKURF\WH R[DODWH ᚐX[ GLᚎHUHQFHRIS+YDOXH7KHHU\WKURF\WHEDQG,,,WUDQVSRUWSURWHLQ 6/&D ZDV GHWHUPLQHGZLWK:HVWHUQ%ORWDQDO\VHV %DQG,,,DQWLERG\*$3'+DVUHIHUHQFH $GGLWLRQDOO\ SODVPD DQG XULQDU\ R[DODWH FRQFHQWUDWLRQ IURP D VLQJOH XULQH VSRW ZHUH DQDO\VHG 6WDWLVWLF DQDO\VHV ZHUH GRQH XVLQJ 87HVW 0DQQ:KLWQH\ DQG 6SHDUPDQFRUUHODWLRQVFRHᚑFLHQW Results: 7KH PHDQ FHOOXODU R[DODWH FRQFHQWUDWLRQV ZHUH VLJQLᚏFDQWO\ ORZHU LQ U&20 VWRQH IRUPHUV S 7KH FHOOXODU R[DODWH FRUUHODWHG ZLWK HU\WKURF\WH R[DODWHLQᚐX[S+SODVPDR[DODWHDQGGLDEHWHV U U LQU&20 3HUFHQWDJHRI &20VWRQH 3ODVPDR[DODWH wPROO &HOOXODUR[DODWH wPROO EDQG,,,WUDQVSRUW SURWHLQ5%& (U\WKURF\WH R[DODWHLQᚐX[S+ wPROO K XULQDU\R[DODWH *)5[ PPROO
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Conclusions: ,Q FRPSDULVRQ WR SULPDU\ FDOFLXP R[DODWH PRQRK\GUDWH VWRQH IRUPHUV S&20 VLJQLᚏFDQWO\ORZHUYDOXHVRIFHOOXODUR[DODWHLQUHFXUUHQWFDOFLXP R[DODWHPRQRK\GUDWHVWRQHIRUPHUV U&20 ZHUHDVVRFLDWHGZLWKR[DODWHWUDQVSRUW GHᚏFLHQF\DQGPHWDEROLFGLVRUGHUV
474
ERYTHROCYTE OXIDANT STRESS IN PATIENTS WITH UROLITHIASIS CORRELATES WITH STONE SIZE AND RENAL TUBULAR DAMAGE
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Introduction & Objectives: 2[LGDWLYHVWUHVVLVDVVRFLDWHGZLWKXUROLWKLDVLVDQGLV NQRZQWRIDYRXUGLVHDVHSURJUHVVLRQE\GHWHULRUDWLQJNLGQH\IXQFWLRQ&LUFXODWLQJ HU\WKURF\WHV DUH HTXLSSHG ZLWK D KLJKO\ HᚎHFWLYH DQWLR[LGDQW GHIHQFH IRU HQGRJHQRXVO\VFDYHQJLQJIUHHUDGLFDOV7KHDLPRIWKHVWXG\ZDVWRLQYHVWLJDWHWKH UHODWLRQVKLSEHWZHHQR[LGDWLYHVWUHVVELRPDUNHUVLQEORRGFHOOVDQGUHQDOWXEXODU GDPDJHZLWKWKHVL]HRIFDOFLXPR[DODWH &D2[ VWRQH Material & Methods: 7KLVVWXG\LQFOXGHG QRUPDOFRQWUROVXEMHFWV SDWLHQWV ZLWK NLGQH\ VWRQHV .6 DQG SDWLHQWV ZLWK XUHWHUDO VWRQHV 86 &D2[ VWRQH GHSRVLWLRQ FDXVHG E\ K\SHUR[DOXULD LQ WZR VWRQH JURXSV ZDV DVVRFLDWHG ZLWK LQFUHDVHG XULQDU\ H[FUHWLRQ RI R[DODWH PDORQGLDOGHK\GH DQG WXEXODU PDUNHU JOXWDWKLRQH6WUDQVIHUDVHDVZHOODVORZHUHGXULQDU\FLWUDWHH[FUHWLRQ(Q]\PDWLF DFWLYLW\ ZDV PHDVXUHG E\ WKH FRPPHUFLDO DYDLODEOH NLW 3URWHLQ H[SUHVVLRQ LQ HU\WKURF\WHRUOHXNRF\WHZDVH[DPLQHGE\:HVWHUQEORW Results: ,Q WKH HU\WKURF\WH DQWLR[LGDQW GHIHQFH DV WKH DPRXQW RI UHGXFHG JOXWDWKLRQH DQG WKH DFWLYLWLHV RI FDWDODVH DQG FRSSHU]LQFVXSHUR[LGH GLVPXWDVH ZHUH VLJQLᚏFDQWO\ GHFUHDVHG LQ ERWK VWRQH JURXSV ZKHQ FRPSDUHG WR FRQWURO 7KH DFWLYLWLHV RI JOXWDWKLRQH SHUR[LGDVH DQG JOXWDWKLRQH UHGXFWDVH ZHUH DOVR GHFUHDVHGLQWKH86JURXS&KDQJHVLQHU\WKURF\WHR[DODWHZHUHFRUUHODWHGZLWK PDORQGLDOGHK\GHSRVLWLYHO\DQGWKHDFWLYLW\RIDQWLR[LGDQWSURWHLQQHJDWLYHO\7RWHVW ZKHWKHUWKHFLUFXODWLQJOHXNRF\WHVLVDQRWKHUVRXUFHIRUIUHHUDGLFDOVJHQHUDWLRQ
Eur Urol Suppl 2010;9(2):167