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485. Long-T erm Remission of Diabetes by a Single Long-Term Intravenous Injection of a Recombinant AdenoAssociated Virus Carrying a Modified Insulin Gene under a Glucose Regulatable Promoter Su-Jin Kim,1 Hee-Sook Jun,1 Seungjin Shin,1 Jaeseok Han,1 Ji-Won Yoon.1 1 Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada. 8 "
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486. Sheep Chimeric Model for Analysis of Engraftment of Retrovirus T ransduced CD34+ Cells Used Transduced in Clinical Gene Therapy T rials Trials Shepherd H. Schurman,1 G. Jayashree Jagadeesh,1 Christopher D. Porada,2 Linda M. Muul,1 Esmail D. Zanjani,3 Fabio Candotti.1 1 Genetics and Molecular Biology Branch, NHGRI / NIH, Bethesda, MD, United States; 2Department of Animal Biotechnology, School of Veterinary Medicine, University of Nevada, Reno, Reno, NV, United States; 3Department of Internal Medicine, VA Medical Center, University of Nevada Reno School of Medicine, Reno, NV, United States.
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487. Risk of Inadvertent Germline T ransmission of Transmission Vector DNA Following Intravascular Delivery of Recombinant AA VV ector AAV Vector V. R. Arruda,1 L. Couto,2 D. Leonard,3 K. Addya,3 J. Sommer,2 R. W. Herzog,1 M. A. Kay,4 B. Glader,4 C. Manno,1 A. Chew,1 K. A. High.1 1 Pediatrics, The Children′s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, United States; 2Avigen, Inc., Alameda, CA, United States; 3University of Pennsylvania School of Medicine, Philadelphia, PA, United States; 4Pediatrics and Genetics, Stanford Univeristy, Stanford, CA, United States. " 3 ''. ?F
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486. Sheep Chimeric Model for Analysis of Engraftment of Retrovirus T ransduced CD34+ Cells Used Transduced in Clinical Gene Therapy T rials Trials Shepherd H. Schurman,1 G. Jayashree Jagadeesh,1 Christopher D. Porada,2 Linda M. Muul,1 Esmail D. Zanjani,3 Fabio Candotti.1 1 Genetics and Molecular Biology Branch, NHGRI / NIH, Bethesda, MD, United States; 2Department of Animal Biotechnology, School of Veterinary Medicine, University of Nevada, Reno, Reno, NV, United States; 3Department of Internal Medicine, VA Medical Center, University of Nevada Reno School of Medicine, Reno, NV, United States.
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