4870076 Sulphonamidoethyl compounds, pharmaceutical compositions comprising these compounds and processes for preparing them

New Patents together represent a second bond between the 6position and 7-position carbon atoms, or, respectively, are each H; X is O, two H atoms or hydroximino; Z is the residue of a pentagonal or hexagonal ring which is optionally substituted and optionally saturated; RI is vinyl, C3-7cyclo-l-alkenyl, phenyl, naphthyl or 5- or 6membered heterocyclic aromatic having at least one N, O or S atom, each being unsubstituted or substituted by 1-3 halogen atoms, 1-3 CI-4alkyl, CI-4-alkoxy, CI-4-acyl, C2-10-alkenyl, CI-4-acyloxy, phenyl, nitro, hydroxy, carboxy, cyanide, COOR4 or amino optionally substituted by !-2 CI-4-alkyi; R2 is methyl or ethyl, R3 is H, CI or methyl; and R4 is CI-4-alkyl optionally substituted by phenyl which itself is optionally substituted by CI-4-alkyl, CI-4alkoxy, halogen or phenyl have valuable pharmacological properties.

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487~87 INDOLE CONTAINING, 2THIENYL-I,2,3,6 TETRAHYDROPYRIDYLS AND THEIR PHARMACEUTICAL USE Rudolf Gottschlich, Henning Bottcher, HansHeinrich Hausberg, Klaus-Otto Minck, Christoph Seyfried, Reinheim, Federal Republic Of Germany assigned to Merck Patent Gesellschaft Mit Beschrankter Haftung Indole derivatives of the general formula I See Patent for Chemical Structure I in which Ind is a 3-indolyl radical which can be substituted once or twice by alkyl, O-alky, S-alkyl, SO-alkyl, SO2-alkyl, OH, F, CI, Br, CF3 and/or CN or by a methylenedioxygroup, A is -(CH2)4- or -CH2L-CH2CH2-, L is -S-, -SO- or -SO2-, and Th is a 2- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts exhibit effects on the central nervous system.

4870076 SULPHONAMIDOETHYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM Armin Heckel, Josef Nickl, Erich Muller, Berthold Narr, Johannes Weisenberger, Wolfgang Eisert, Thomas Muller, Biberach, Federal Republic Of Germany assigned to Karl Thomae GmbH The invention relates to new sulphonamidoethyl compounds having the following structure: See Patent for Chemical Structure wherein R I is substituted or unsubstituted phenyl, benzyl, nitrophenyl, acetamidophenyl or thienyl, R2 is hydroxycarbonyl or alkoxycarbonyl bonded via alkylene or alkenylene, or a 4,5-dihydropyridazin-3-one-6-yl or pyridazin-3-on-6-yl group optionally substituted on a ring carbon by C1-C3 alkyl and X is substituted or unsubstituted imino, oxygen or sulphur, which compounds may be used to prevent arteriosclerosis or tumor metastasis, and are antitrombotic and thromboxane antagonists.

4870097 PHARMACEUTICAL USE OF DERIVATIVES OF TRYPTOPHAN Francesc Makovec, Rolando Chiste, Angelo L Rovati, Monza, Italy assigned to Rotta Research Laboratorium S p A N-acylated derivatives of L-tryptophan of general formula (I), See Patent for Chemical Structure (I) in which R is selected from the group consisting of: (a) a phenyl group, monosubstituted or di-substituted in the meta and para positions with halogens, linear or branched alkyl groups containing from 1 to 9 carbon atoms, the cyano group or the trifluoromethyl group, (b) a benzyloxy group, mono-substituted or di-substituted in the meta and para position with substituents selected from those indicated at (a), and (c) a benzydryloxy group. The derivatives are used in therapy, particularly for human pain relief, in the treatment of pathological conditions of the central nervous system and of pathological intestinal conditions.