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4871736 Stereoisomeric tricyclic bis(dioxopiperazines) and pharmaceutical compositions
New Patents
ix
The invention refers to a novel pharmaceutical composition having especially antimycotic activity and comprising the zinc complex of 5chloro-7-iodo-8-hydroxyquinoline of formula (I) See Patent for Chemical Structure (I) and one or more pharmaceutically acceptable carriers. The pharmaceutical composition of the invention can be used for the effective treatment of mycotic infections on the skin surface, mucous membranes or nails. The complex of formula (I) is prepared by reacting a solution of an alkali metal salt of 5-chloro-7-iodo-8hydroxyquinoline with a solution containing an excess of an inorganic or organic zinc salt or a zinc complex having a lower stability constant than that of the complex of formula (I) and separating the product precipitated.
Stereoisomeric tricyclic bis(dioxopiperazines) of the formula See Patent for Chemical Structure wherein R is H or See Patent for Chemical Structure and the processes for the synthesis thereof are provided. The compounds are effective as antitumor or antimetastatic drugs.
4871735
4871742
NAPHTHYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE C O M P O U N D S AND PROCESSES FOR PREPARING THEM
PROCESS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF GLAUCOMA
Joachi Heider, Manfre Psiorz, Andreas Bomhard, Norbert Hauel, Berthold Narr, Klaus Noll, Christia Lillie, Walter Kobinger, Jurgen Dammgen, Warthausen, Federal Republic Of Germany assigned to Dr Karl Thomae G m b H The present invention relates to new naphthyl derivatives of general formula See Patent for Chemical Structure (I) wherein N represents the number 1 or 2, A represents a -CH2-, -CO-, CH2CH2-, -CH double bondCH-, See Patentfor Chemical Structure while the atom marked with an x is linked to the phenyl nucleus, E represents a straight chained alkylene group optionally substituted by an alkyl group, G represents a straight chained alkylene group optionally substituted by an alkyl group, L represents a bond or an oxygen atom, if G represents a straight chained alkylene group with 2 to 5 carbon atoms optionally substituted by an alkyl group, R1 and R2, which may be identical or different, represent alkyl or alkoxy groups or RI and R2 together represent an alkylenedioxy group, R3 represents a hydrogen atom, or an alkyl or an allyl group, R4, R5 and R6, which may be identical or different, represent hydrogen atoms, alkyl or alkuxy groups, the enantiomers and the acid addition salts thereof, which have valuable pharmacological properties, particularly a heart rate lowering activity. The new compounds may be prepared using methods known per se.
4871736 STEREOISOMERIC TRICYCLIC BIS(DIOXOPIPERAZINES) AND PHARMACEUTICAL COMPOSITIONS Raghunathan V Nair, Donald T Witiak assigned to The Ohio State University
Claude Bonne, Claud Coquelet, Elisabeth Latour, Montpellier, France assigned to Laboratories Chauvin The invention relates to a process for the treatment of glaucoma comprising administering to a human in need thereof an effective amount o f a compound selected from the inhibitors of xanthine-oxidase.
4871772 PROCESS FOR MAKING A STABLE PHARMACEUTICAL PREPARATION OF PROSTAGLADIN E COMPOUNDS, AND/OR 15R FORMS THEREOF Kohtar Miwa, Kazuo Igusa, Toshichika Ogasawara, Tokyo, Japan assigned to Chugai Seiyaku Kabushiki Kaisha A process for making a stable pharmaceutical preparation of prostaglandin E compounds and/or 15R forms thereof is diclosed. Prostagladin E compounds and 15R forms thereof are know to have useful pharmacological actions even if they are used in a vary small amounts. However, they are extremely unstable and, therefore, considerably difficult in application for routine clinical purposes. In order to remove this difficulty, prostagladin E compounds and
ix
The invention refers to a novel pharmaceutical composition having especially antimycotic activity and comprising the zinc complex of 5chloro-7-iodo-8-hydroxyquinoline of formula (I) See Patent for Chemical Structure (I) and one or more pharmaceutically acceptable carriers. The pharmaceutical composition of the invention can be used for the effective treatment of mycotic infections on the skin surface, mucous membranes or nails. The complex of formula (I) is prepared by reacting a solution of an alkali metal salt of 5-chloro-7-iodo-8hydroxyquinoline with a solution containing an excess of an inorganic or organic zinc salt or a zinc complex having a lower stability constant than that of the complex of formula (I) and separating the product precipitated.
Stereoisomeric tricyclic bis(dioxopiperazines) of the formula See Patent for Chemical Structure wherein R is H or See Patent for Chemical Structure and the processes for the synthesis thereof are provided. The compounds are effective as antitumor or antimetastatic drugs.
4871735
4871742
NAPHTHYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE C O M P O U N D S AND PROCESSES FOR PREPARING THEM
PROCESS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF GLAUCOMA
Joachi Heider, Manfre Psiorz, Andreas Bomhard, Norbert Hauel, Berthold Narr, Klaus Noll, Christia Lillie, Walter Kobinger, Jurgen Dammgen, Warthausen, Federal Republic Of Germany assigned to Dr Karl Thomae G m b H The present invention relates to new naphthyl derivatives of general formula See Patent for Chemical Structure (I) wherein N represents the number 1 or 2, A represents a -CH2-, -CO-, CH2CH2-, -CH double bondCH-, See Patentfor Chemical Structure while the atom marked with an x is linked to the phenyl nucleus, E represents a straight chained alkylene group optionally substituted by an alkyl group, G represents a straight chained alkylene group optionally substituted by an alkyl group, L represents a bond or an oxygen atom, if G represents a straight chained alkylene group with 2 to 5 carbon atoms optionally substituted by an alkyl group, R1 and R2, which may be identical or different, represent alkyl or alkoxy groups or RI and R2 together represent an alkylenedioxy group, R3 represents a hydrogen atom, or an alkyl or an allyl group, R4, R5 and R6, which may be identical or different, represent hydrogen atoms, alkyl or alkuxy groups, the enantiomers and the acid addition salts thereof, which have valuable pharmacological properties, particularly a heart rate lowering activity. The new compounds may be prepared using methods known per se.
4871736 STEREOISOMERIC TRICYCLIC BIS(DIOXOPIPERAZINES) AND PHARMACEUTICAL COMPOSITIONS Raghunathan V Nair, Donald T Witiak assigned to The Ohio State University
Claude Bonne, Claud Coquelet, Elisabeth Latour, Montpellier, France assigned to Laboratories Chauvin The invention relates to a process for the treatment of glaucoma comprising administering to a human in need thereof an effective amount o f a compound selected from the inhibitors of xanthine-oxidase.
4871772 PROCESS FOR MAKING A STABLE PHARMACEUTICAL PREPARATION OF PROSTAGLADIN E COMPOUNDS, AND/OR 15R FORMS THEREOF Kohtar Miwa, Kazuo Igusa, Toshichika Ogasawara, Tokyo, Japan assigned to Chugai Seiyaku Kabushiki Kaisha A process for making a stable pharmaceutical preparation of prostaglandin E compounds and/or 15R forms thereof is diclosed. Prostagladin E compounds and 15R forms thereof are know to have useful pharmacological actions even if they are used in a vary small amounts. However, they are extremely unstable and, therefore, considerably difficult in application for routine clinical purposes. In order to remove this difficulty, prostagladin E compounds and