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4874691 Membrane-supported immunoassays
PATENT ABSTRACTS
4874520 CHROMATOGRAPHIC
413
radiation, head trauma, and acute and chronic encephalitic and vascular disease. PROCESS
Siu-Leung Lee assigned to Battelle Development Corporation 4874695 A new class of chromatographic columns for reverse phase and ion exchange chromatography based on organotitanate coupling is disclosed along with separation processes using such media. The disclosed organo-titanate coupled matrices useful for reverse phase or ionic chromatographic separation can be made using titanat¢ coupling agents in complete replacement of conventional silanating agents.
4874691 MEMBRANE-SUPPORTED IMMUNOASSAYS Howard Chandler, West Vancouver, Canada assigned to Quadra Logic Technologies Inc Improved, economical devices for immunoassays employ a reusable syringe or vacuum manifold to withdraw samples through a membrane containing an affinity partner for analyte. The devices can also be adapted to direct blood sampling and to automated assays.
RAPID INDENTIFICATION OF YEAST AND OTHER FUNGAL MICROORGANISMS BY ENZYME DETECTION David H Pincus assigned to American Home Products Corp Rapid identification of different species of microorganism selected from fungi and yeast like algae is accomplished by culturing the microorganism for several hours under normal conditions on a non-inhibitory mycological medium which stimulates the microorganism to make characteristic enzymes by which the microorganism can be identified, distributing the culture (in suspension) onto several supports containing different substrates which are capable of reacting with the enzymes so produced by the different species of microorganisms; and rapidly incubating the admixture to produce a distinctly colored or colorable reaction product.
4874696 4874694 USE OF PHOSPHOPROTEIN PATTERNS FOR DIAGNOSIS OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
NOVEL BACTERIUM INDUCIBLE TO PRODUCE UNIQUE STEROIDTRANSFORMING ENZYMES: PREPARATION AND APPLICATIONS THEREOF
Samuel E Gandy, Paul Greengard assigned to The Rockefeller University
Donna W Payne, Pau Talalay assigned to The Johns Hopkins University Med School
A diagnostic method for neurological and psychiatric disorders utilizes the cercbrospinal fluid incubated in the presence of 32-P labelled ATP and an appropriate protein kinase. After termination of the reaction, a sample is applied to gels for electrophoresis. Subsequent autoradiography results in a disease-specific protein pattern that can be used for diagnosis of disorders such as Alzheimer disease, Huntington disease, Parkinson disease, dystonia ataxia, schizophrenia, epilepsy brain tumors, brain ir-
The present invention discloses a unique biologically pure culture of a microorganism belonging to Alcaligenes species. The microorganism has the property of producing novel 17 beta-hydroxysteroid dehydrogenase (17 betaHSD) capable of enzymatic reaction with an androgen and an estrogen. The methods of isolation the microorganism and the 17 betaHSD have been described. An assay and a kit for detectingthepresenceofC18andCl9steroidsin biological samples have also been disclosed.
4874520 CHROMATOGRAPHIC
413
radiation, head trauma, and acute and chronic encephalitic and vascular disease. PROCESS
Siu-Leung Lee assigned to Battelle Development Corporation 4874695 A new class of chromatographic columns for reverse phase and ion exchange chromatography based on organotitanate coupling is disclosed along with separation processes using such media. The disclosed organo-titanate coupled matrices useful for reverse phase or ionic chromatographic separation can be made using titanat¢ coupling agents in complete replacement of conventional silanating agents.
4874691 MEMBRANE-SUPPORTED IMMUNOASSAYS Howard Chandler, West Vancouver, Canada assigned to Quadra Logic Technologies Inc Improved, economical devices for immunoassays employ a reusable syringe or vacuum manifold to withdraw samples through a membrane containing an affinity partner for analyte. The devices can also be adapted to direct blood sampling and to automated assays.
RAPID INDENTIFICATION OF YEAST AND OTHER FUNGAL MICROORGANISMS BY ENZYME DETECTION David H Pincus assigned to American Home Products Corp Rapid identification of different species of microorganism selected from fungi and yeast like algae is accomplished by culturing the microorganism for several hours under normal conditions on a non-inhibitory mycological medium which stimulates the microorganism to make characteristic enzymes by which the microorganism can be identified, distributing the culture (in suspension) onto several supports containing different substrates which are capable of reacting with the enzymes so produced by the different species of microorganisms; and rapidly incubating the admixture to produce a distinctly colored or colorable reaction product.
4874696 4874694 USE OF PHOSPHOPROTEIN PATTERNS FOR DIAGNOSIS OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
NOVEL BACTERIUM INDUCIBLE TO PRODUCE UNIQUE STEROIDTRANSFORMING ENZYMES: PREPARATION AND APPLICATIONS THEREOF
Samuel E Gandy, Paul Greengard assigned to The Rockefeller University
Donna W Payne, Pau Talalay assigned to The Johns Hopkins University Med School
A diagnostic method for neurological and psychiatric disorders utilizes the cercbrospinal fluid incubated in the presence of 32-P labelled ATP and an appropriate protein kinase. After termination of the reaction, a sample is applied to gels for electrophoresis. Subsequent autoradiography results in a disease-specific protein pattern that can be used for diagnosis of disorders such as Alzheimer disease, Huntington disease, Parkinson disease, dystonia ataxia, schizophrenia, epilepsy brain tumors, brain ir-
The present invention discloses a unique biologically pure culture of a microorganism belonging to Alcaligenes species. The microorganism has the property of producing novel 17 beta-hydroxysteroid dehydrogenase (17 betaHSD) capable of enzymatic reaction with an androgen and an estrogen. The methods of isolation the microorganism and the 17 betaHSD have been described. An assay and a kit for detectingthepresenceofC18andCl9steroidsin biological samples have also been disclosed.