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4874759 5-Hydroxyindole 3-carboxylic acid amide compounds, pharmaceutical compositions and use
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New Patents
Structure (1) wherein the variables are as defined herein. The present invention also provides processes for the preparation thereof, pharmaceutical compositions containing them and intermediates for the preparation thereof.
therapeutic medicine for circulation system diseases.
4874758
PHARMACEUTICALLY EFFICACIOUS PTERIDINE DERIVATIVES
NOVEL ENOLAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF FOR ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE Mary E Carethers, Wiaczeslaw A Centenko, David T Connor, Elizabeth Johnson, John S Kiely, Charles Schwender, Jagadish C Sircar, Roderick Sorenson, Paul C Unangst, Robert F Bruns assigned to Warner-Lambert Company The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and method of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
4874759 5-HYDROXYINDOLE 3CARBOXYLIC ACID AMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE Tetsuya Tahara, Tsuguo Ikebe, Ichiro Hakamada, Osamu Yaoka, Nakatsu, Japan assigned to Yoshitomi Pharmaceutical Industries Ltd Hydroxyindole 3-carboxylic acid amide compounds of the general formula: See Patent for Chemical Structure wherein RI, R2, R3 and R4 are, the same or different, respectively a hydrogen atom, an alkyl group, an aryl group, an aralkyl group or a heteroaryi group, or RI and R2 and/or R3 and R4 are respectively groups which are combined to each other taken together with the adjacent nitrogen atom to form a heterocyclic group, R5 is an alkyl group, R6 is a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group or an aralkyl group and X is a hydrogen atom, a halogen atom or a lower alkanoyl group, or their acid addition salts. These compounds are of use as diuretics or a
4874763
Ingri Hofmann, Erns Mutschler, Angelik Christner, Frankfurt am Main, Federal Republic Of Germany assigned to Roehm G m b H Chemische Fabrik A pharmaceutically efficacious pteridine compound of formula: See Patent for Chemical Structure I wherein R I is hydrogen, halogen, trifluoromethyl, nitro, a -(A)n-OR3 group, wherein R3 is hydrogen or a C 1-6 alkyl group, a (A)n-NR4R5 group, wherein R4 and R5 independently of each other are hydrogen or a CI-6 alkyl group or R4 and R5 together with the nitrogen atom form a 5- or 6-membered ring that is substituted with a C1-4 alkyl group and wherein A is a linking group having I to 6 linking carbon atoms, one of which can be replaced by oxygen and wherein n is zero or one, and wherein R2 is hydrogen or, independently of R 1, has the same meaning as RI, with the proviso that RI and R2 are not simultaneously hydrogen, and the physiologically acceptable acid addition salts thereof.
487~73 3-AMINOCARBONYL-I 4DIHYDROPYRIDINE-5CARBOXYLIC ACID COMPOUNDS, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME Masakatu Hisaki, Kenichi Kashima, Yasuhiko Sakamoto, Masakazu Hojo, Osamu Katayama, Hiroyoshi Hata, Hikone, Japan assigned to Nippon Shoji Kabushiki Kaisha Novel 3-aminocarbonyl-I 4-dihydropyridine-5carboxylic acid compounds of the formula: See Patent for Chemical Structure (I) wherein RI is H, C1-5 alkyl, C2-5 alkenyl, C3.5 alkynyi, C3-8 cycloalkyl, R2 is Ci-10 alkyl, and the NO2 group is substituted at ortho- or meta-position, provided that when the NO2 group is substituted at ortho-position and R2 is methyl, RI is C3-5
New Patents
Structure (1) wherein the variables are as defined herein. The present invention also provides processes for the preparation thereof, pharmaceutical compositions containing them and intermediates for the preparation thereof.
therapeutic medicine for circulation system diseases.
4874758
PHARMACEUTICALLY EFFICACIOUS PTERIDINE DERIVATIVES
NOVEL ENOLAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF FOR ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE Mary E Carethers, Wiaczeslaw A Centenko, David T Connor, Elizabeth Johnson, John S Kiely, Charles Schwender, Jagadish C Sircar, Roderick Sorenson, Paul C Unangst, Robert F Bruns assigned to Warner-Lambert Company The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and method of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
4874759 5-HYDROXYINDOLE 3CARBOXYLIC ACID AMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE Tetsuya Tahara, Tsuguo Ikebe, Ichiro Hakamada, Osamu Yaoka, Nakatsu, Japan assigned to Yoshitomi Pharmaceutical Industries Ltd Hydroxyindole 3-carboxylic acid amide compounds of the general formula: See Patent for Chemical Structure wherein RI, R2, R3 and R4 are, the same or different, respectively a hydrogen atom, an alkyl group, an aryl group, an aralkyl group or a heteroaryi group, or RI and R2 and/or R3 and R4 are respectively groups which are combined to each other taken together with the adjacent nitrogen atom to form a heterocyclic group, R5 is an alkyl group, R6 is a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group or an aralkyl group and X is a hydrogen atom, a halogen atom or a lower alkanoyl group, or their acid addition salts. These compounds are of use as diuretics or a
4874763
Ingri Hofmann, Erns Mutschler, Angelik Christner, Frankfurt am Main, Federal Republic Of Germany assigned to Roehm G m b H Chemische Fabrik A pharmaceutically efficacious pteridine compound of formula: See Patent for Chemical Structure I wherein R I is hydrogen, halogen, trifluoromethyl, nitro, a -(A)n-OR3 group, wherein R3 is hydrogen or a C 1-6 alkyl group, a (A)n-NR4R5 group, wherein R4 and R5 independently of each other are hydrogen or a CI-6 alkyl group or R4 and R5 together with the nitrogen atom form a 5- or 6-membered ring that is substituted with a C1-4 alkyl group and wherein A is a linking group having I to 6 linking carbon atoms, one of which can be replaced by oxygen and wherein n is zero or one, and wherein R2 is hydrogen or, independently of R 1, has the same meaning as RI, with the proviso that RI and R2 are not simultaneously hydrogen, and the physiologically acceptable acid addition salts thereof.
487~73 3-AMINOCARBONYL-I 4DIHYDROPYRIDINE-5CARBOXYLIC ACID COMPOUNDS, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME Masakatu Hisaki, Kenichi Kashima, Yasuhiko Sakamoto, Masakazu Hojo, Osamu Katayama, Hiroyoshi Hata, Hikone, Japan assigned to Nippon Shoji Kabushiki Kaisha Novel 3-aminocarbonyl-I 4-dihydropyridine-5carboxylic acid compounds of the formula: See Patent for Chemical Structure (I) wherein RI is H, C1-5 alkyl, C2-5 alkenyl, C3.5 alkynyi, C3-8 cycloalkyl, R2 is Ci-10 alkyl, and the NO2 group is substituted at ortho- or meta-position, provided that when the NO2 group is substituted at ortho-position and R2 is methyl, RI is C3-5