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4966852 DNA clone of human tissue factor inhibitor
PATENT ABSTRACTS
84
4966846 MOLECULAR CLONING AND EXPRESSION OF A VIBRIO PROTEOLYTICUS NEUTRAL PROTEASE GENE Alan H Deutch, Victor A David assigned to W R Grace & Co -Conn Neutral protease genes from Vibrio proteolyticus or Bacillus can be cloned and expressed in gram-negative microorganisms, such as E. coli or Serratia. The functional neutral protease enzyme is expressed.
4966847 RECOMBINANT DNA CLONES CONTAINING A BROAD HOST RANGE GENE FROM BRADYRHIZOBIUM JAPONICUM Gar Stacey, Anthony J Nieuwkoop, Zsofia Banfalvi Recombinant D N A clones according to the invention contain a host range gene of B. japonicum which is contained within a 3.3 kb HindIII restriction fragment from the B. japonicum chromosome. Mutations to this gene change the ability of the bacteria to nodulate different plants. In one example, a Tn5 insertion to this region caused the strain to lose its ability to nodulate siratro, but nodulation of soybeans was unaffected. This gene may be manipulated to extend or restrict the host range of the strain for agricultural purposes. 4966848 ISOLATION, PURIFICATION, CHARACTERIZATION, CLONING AND SEQUENCING OF N ALPHAACETYLTRANSFERASE
pmol of acetyl residues incorporated into adrenocorticotropic hormone (ACTH) (amino acids 1-24) under standard assay conditions. This invention is further directed to amethod for purifying the N alpha-acetyltransferase.
4966849 CDNA AND GENES FOR HUMAN ANGIOGENIN (ANGIOGENESIS FACTOR) AND METHODS OF EXPRESSION Bert L Vallee, Kotoku Kurachi assigned to President and Fellows of Harvard College DNA sequences encoding a protein having angiogenic activity and mutated DNA sequences encoding a protein having decreased angiogenic activity are disclosed. Expression vectors containing these wild-type or mutated sequences are introduced into host cells and direct the production of wild-type or mutant angiogenic proteins. Proteins produced according to the invention are useful in the diagnosis of malignancies, for promoting wound healing, and for other diagnostic and therapeutic purposes. Mutant proteins produced according to the invention are useful therapeutic compositions as angiogensis inhibitors, which may retard tumor growth by inhibiting the development of a hemovascular network.
4966852 DNA CLONE OF HUMAN TISSUE FACTOR INHIBITOR Tze-Chein Wun, Kuniko Kretzmer, George J Broze assigned to Monsanto Company; Washington Universi A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined.
John A Smith, Fang-Jen S Lee assigned to The General Hospital Corporation This invention is directed to N alphaacetyltransferase with a molecular weight of about 180,000 daltons, said N alphaacetyltransferase being composed of two subunit peptides having molecular weights of about 95,000 each, having enzyme activity greater than 100 wherein one unit of activity is defined as 1
4968603 DETERMINATION NEOPLASTIC
OF STATUS IN DISEASE
Dennis J Slamon, William L McGuire assigned to The Regents of the University of California
84
4966846 MOLECULAR CLONING AND EXPRESSION OF A VIBRIO PROTEOLYTICUS NEUTRAL PROTEASE GENE Alan H Deutch, Victor A David assigned to W R Grace & Co -Conn Neutral protease genes from Vibrio proteolyticus or Bacillus can be cloned and expressed in gram-negative microorganisms, such as E. coli or Serratia. The functional neutral protease enzyme is expressed.
4966847 RECOMBINANT DNA CLONES CONTAINING A BROAD HOST RANGE GENE FROM BRADYRHIZOBIUM JAPONICUM Gar Stacey, Anthony J Nieuwkoop, Zsofia Banfalvi Recombinant D N A clones according to the invention contain a host range gene of B. japonicum which is contained within a 3.3 kb HindIII restriction fragment from the B. japonicum chromosome. Mutations to this gene change the ability of the bacteria to nodulate different plants. In one example, a Tn5 insertion to this region caused the strain to lose its ability to nodulate siratro, but nodulation of soybeans was unaffected. This gene may be manipulated to extend or restrict the host range of the strain for agricultural purposes. 4966848 ISOLATION, PURIFICATION, CHARACTERIZATION, CLONING AND SEQUENCING OF N ALPHAACETYLTRANSFERASE
pmol of acetyl residues incorporated into adrenocorticotropic hormone (ACTH) (amino acids 1-24) under standard assay conditions. This invention is further directed to amethod for purifying the N alpha-acetyltransferase.
4966849 CDNA AND GENES FOR HUMAN ANGIOGENIN (ANGIOGENESIS FACTOR) AND METHODS OF EXPRESSION Bert L Vallee, Kotoku Kurachi assigned to President and Fellows of Harvard College DNA sequences encoding a protein having angiogenic activity and mutated DNA sequences encoding a protein having decreased angiogenic activity are disclosed. Expression vectors containing these wild-type or mutated sequences are introduced into host cells and direct the production of wild-type or mutant angiogenic proteins. Proteins produced according to the invention are useful in the diagnosis of malignancies, for promoting wound healing, and for other diagnostic and therapeutic purposes. Mutant proteins produced according to the invention are useful therapeutic compositions as angiogensis inhibitors, which may retard tumor growth by inhibiting the development of a hemovascular network.
4966852 DNA CLONE OF HUMAN TISSUE FACTOR INHIBITOR Tze-Chein Wun, Kuniko Kretzmer, George J Broze assigned to Monsanto Company; Washington Universi A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined.
John A Smith, Fang-Jen S Lee assigned to The General Hospital Corporation This invention is directed to N alphaacetyltransferase with a molecular weight of about 180,000 daltons, said N alphaacetyltransferase being composed of two subunit peptides having molecular weights of about 95,000 each, having enzyme activity greater than 100 wherein one unit of activity is defined as 1
4968603 DETERMINATION NEOPLASTIC
OF STATUS IN DISEASE
Dennis J Slamon, William L McGuire assigned to The Regents of the University of California