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5008273 Amino acid derivatives and their pharmaceutical use
New Patents
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5008265
5008270
2-AMINO-7- (ALICYCLOMETHYL) -3H, 5H,-PYRROLO (3,2-D) PYRIMIDIN+ONES AND PHARMACEUTICAL USES AND COMPOSITIONS CONTAINING THE SAME
2-AMINO-7(HETEROCYCLOMETHYL) -3H, SH-PYRROLO (3,2-D) PYRIMIDINCONES AND PHARMACEUTICAL USES AND COMPOSITIONS CONTAINING THE SAME
John A Secrist, John A Montgomery, Steve E Ealick, Mark Erion, Wayne C Guida assigned to BioCryst Inc
John A Secrist, John A Montgomery, Steve E Ealick, Mark Erion, Wayne C Guida assigned to BioCryst Inc
Disclosed is a compound containing a 2-amino7-(substituted methyl)-3H, SH-pyrrolo (3,2-d) pyrimidin4-one wherein substituted methyl is CHZR wherein R is an optionally substituted alicyclic group, a pharmaceutical composition containing the compound, and a method for the selective suppression of mammalian T-cell function without diminished effect on humoral immunity which involves administering the composition to a mammal.
Disclosed is a compound containing a 2-amino7-(substituted methyl)-3, 5pyrrolo(3,2d)pyrimidin-4-one wherein substituted methyl is -CHZ-R wherein R is an optionally substituted heteroalicyclic group, a pharmaceutical composition containing the compound, and a method for the selective suppression of mammalian T-cell function without diminished effect on humoral immunity which involves administering the composition to a mammal.
5008273
5008266 4(3H)-QUINAZOLINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS Toshihiro Takahashi, Tatsuo Horaguchi, Koichi Nakamaru, Yoshikuni Suzuki, Kawagoe, Japan assigned to Nisshin Flour Milling Co Ltd 4(3H)-Quinazolinone derivative of formula (I) are provided. See Patent for Chemical Structure (I) wherein Rl is a hydrogen atom, a Cl-C6 alkyl group, an aryl group, a substituted aryl group, or an aralkyl group; R2 is a Cl-C6 alkylamino group, a phenyl group, a substituted phenyl group, or a 5 or 6-membered heterocyclic group containing one or more N, 0 or S as a hetero atom or atoms, said heterocyclic group optionally being substituted or fused with a benzene ring; n is 1 or 2; or R2 represents a geranyl group or a dipyridylmethyl group together with the group -(CH2)n-; and X is a hydrogen atom, a Cl-C6 alkyl group or a halogen atom, and pharmaceutically acceptable acid addition salts thereof. They are useful as antiucler agents.
AMINO ACID DERIVATIVES THEIR PHARMACEUTICAL
AND USE
Gerd Schnorrenberg, Otto ROOS,Walter Losel, Ingrid Wiedemann, Wolfram Gaida, Wolfgang Hoefke, Dietrich Arndts, Ilse Streller, Gau Algesheim, Federal Republic Of Germany assigned to Boehringer Ingelheim GmbH Amino acid derivatives of general formula See Patent for Chemical Structure (I) (the definitions of the various symbols being explained in the specification) are suitable for treating high blood pressure and for cardioprotection. The new compounds are prepared and used in the usual way.
5008274 CARBOSTYRIL DERIVATIVES AND SALTS THEREOF AND PHARMACEUTICAL COMPOSITION FOR INHIBITING ADHESION OF THROMBOCYTES Takao Nishi, Tetsuyuki Uno, Yasuo Koga, GilNamg Chu, Tokushima, Japan assigned to Otsuka Pharmaceutical Co Ltd
x
5008265
5008270
2-AMINO-7- (ALICYCLOMETHYL) -3H, 5H,-PYRROLO (3,2-D) PYRIMIDIN+ONES AND PHARMACEUTICAL USES AND COMPOSITIONS CONTAINING THE SAME
2-AMINO-7(HETEROCYCLOMETHYL) -3H, SH-PYRROLO (3,2-D) PYRIMIDINCONES AND PHARMACEUTICAL USES AND COMPOSITIONS CONTAINING THE SAME
John A Secrist, John A Montgomery, Steve E Ealick, Mark Erion, Wayne C Guida assigned to BioCryst Inc
John A Secrist, John A Montgomery, Steve E Ealick, Mark Erion, Wayne C Guida assigned to BioCryst Inc
Disclosed is a compound containing a 2-amino7-(substituted methyl)-3H, SH-pyrrolo (3,2-d) pyrimidin4-one wherein substituted methyl is CHZR wherein R is an optionally substituted alicyclic group, a pharmaceutical composition containing the compound, and a method for the selective suppression of mammalian T-cell function without diminished effect on humoral immunity which involves administering the composition to a mammal.
Disclosed is a compound containing a 2-amino7-(substituted methyl)-3, 5pyrrolo(3,2d)pyrimidin-4-one wherein substituted methyl is -CHZ-R wherein R is an optionally substituted heteroalicyclic group, a pharmaceutical composition containing the compound, and a method for the selective suppression of mammalian T-cell function without diminished effect on humoral immunity which involves administering the composition to a mammal.
5008273
5008266 4(3H)-QUINAZOLINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS Toshihiro Takahashi, Tatsuo Horaguchi, Koichi Nakamaru, Yoshikuni Suzuki, Kawagoe, Japan assigned to Nisshin Flour Milling Co Ltd 4(3H)-Quinazolinone derivative of formula (I) are provided. See Patent for Chemical Structure (I) wherein Rl is a hydrogen atom, a Cl-C6 alkyl group, an aryl group, a substituted aryl group, or an aralkyl group; R2 is a Cl-C6 alkylamino group, a phenyl group, a substituted phenyl group, or a 5 or 6-membered heterocyclic group containing one or more N, 0 or S as a hetero atom or atoms, said heterocyclic group optionally being substituted or fused with a benzene ring; n is 1 or 2; or R2 represents a geranyl group or a dipyridylmethyl group together with the group -(CH2)n-; and X is a hydrogen atom, a Cl-C6 alkyl group or a halogen atom, and pharmaceutically acceptable acid addition salts thereof. They are useful as antiucler agents.
AMINO ACID DERIVATIVES THEIR PHARMACEUTICAL
AND USE
Gerd Schnorrenberg, Otto ROOS,Walter Losel, Ingrid Wiedemann, Wolfram Gaida, Wolfgang Hoefke, Dietrich Arndts, Ilse Streller, Gau Algesheim, Federal Republic Of Germany assigned to Boehringer Ingelheim GmbH Amino acid derivatives of general formula See Patent for Chemical Structure (I) (the definitions of the various symbols being explained in the specification) are suitable for treating high blood pressure and for cardioprotection. The new compounds are prepared and used in the usual way.
5008274 CARBOSTYRIL DERIVATIVES AND SALTS THEREOF AND PHARMACEUTICAL COMPOSITION FOR INHIBITING ADHESION OF THROMBOCYTES Takao Nishi, Tetsuyuki Uno, Yasuo Koga, GilNamg Chu, Tokushima, Japan assigned to Otsuka Pharmaceutical Co Ltd