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5028632 Taste masked medicated pharmaceutical
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New Patents
5028603 ESTER-SUBSTITUTED THIENOTRIAZOLODIAZEPINE COMPOUNDS AND PHARMACEUTICAL USES THEREOF Tetsuya Tahara, Minoru Moriwaki, Masao Abe, Michio Terasawa, Nakatsu, Japan assigned to Yoshitomi Pharmaceutical Industries Ltd There are provided novel ester-substituted thienotriazolodiazepines useful for the treatment of various PAF-induced diseases.
5028626
XXIII
5030447 PHARMACEUTICAL COMPOSITIONS HAVING GOOD STABILITY Yatindra M Joshi, Pierina Chiesa, Nemichand B Jain assigned to E R Squibb & Sons Inc A pharmaceutical compositions is provided which has excellent stability, when dispersed in water has a pH of at least about 9, and includes a medicament which is sensitive to a low pH environment such as pravastatin, one or more fillers such as lactose and/or microcrystalline cellulose, one or more binders, such as mirocrystalline cellulose (dry binder) or polyvinylpyrrolidone (wet binder), one or more disintegrating agents such as croscarmellose sodium, one or more lubricants such as magnesium stearate and one or more basifying agents such as magnesium oxide.
PEPTIDES WITH PHARMACEUTICAL ACTIVITY Dario Chiarino, Angelo Carenzi, Bella Davide Della, Franc0 Pellacini, Monza, Italy assigned to Zambon Group S p A Compounds of formula See Patent for Chemical Structure (I) wherein Rl, R2, R3, R4, and have the meanings reported in the specification, processes for their preparation and pharmaceutical compositions containing them as active ingredient are described. The compounds of formula I are inhibitors of enzymatic systems and they are useful in pharmaceutical field.
5030620 VINBLASTINE DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Jean A A Hannart, Andre B L Trouet, Kandukuri S B Rao, Dion Valmont, Belgium assigned to Omnichem
5028632 TASTE MASKED MEDICATED PHARMACEUTICAL Richard C Fuisz assigned to Fuisz Pharmaceutical Ltd The addition of an extremely small quantity of an anesthetizing agent such as phenol to a medicament dosed saccharide floss serves to numb the taste buds sufficiently that undesirable taste stimulation by the medicament is inhibited.
A description is given of conjugates of vinca alkaloid of the indole-dihydroindole type with a protein or a protein fragment, corresponding to the general formula See Patent for Chemical Structure in which Rl denotes a protein or a protein fragment; R2 is COO(Cl-3 alkyl) or CO-R7 where R7 is NH2 or an amino acid ester or peptide ester; R3 is H, CH3 or CHO; when R5 and R6 are taken separately, R6 is H and one of R4 and R5 is ethyl and the other is H or OH; when R5 and R6 are taken together with the carbon atoms to which they are attached, they form an oxirane ring and R4 is ethyl, and A is a residue of a bifunctional organic derivative of the maleoylamino acid or maleoyl peptide or maleoylphenoxy type.
New Patents
5028603 ESTER-SUBSTITUTED THIENOTRIAZOLODIAZEPINE COMPOUNDS AND PHARMACEUTICAL USES THEREOF Tetsuya Tahara, Minoru Moriwaki, Masao Abe, Michio Terasawa, Nakatsu, Japan assigned to Yoshitomi Pharmaceutical Industries Ltd There are provided novel ester-substituted thienotriazolodiazepines useful for the treatment of various PAF-induced diseases.
5028626
XXIII
5030447 PHARMACEUTICAL COMPOSITIONS HAVING GOOD STABILITY Yatindra M Joshi, Pierina Chiesa, Nemichand B Jain assigned to E R Squibb & Sons Inc A pharmaceutical compositions is provided which has excellent stability, when dispersed in water has a pH of at least about 9, and includes a medicament which is sensitive to a low pH environment such as pravastatin, one or more fillers such as lactose and/or microcrystalline cellulose, one or more binders, such as mirocrystalline cellulose (dry binder) or polyvinylpyrrolidone (wet binder), one or more disintegrating agents such as croscarmellose sodium, one or more lubricants such as magnesium stearate and one or more basifying agents such as magnesium oxide.
PEPTIDES WITH PHARMACEUTICAL ACTIVITY Dario Chiarino, Angelo Carenzi, Bella Davide Della, Franc0 Pellacini, Monza, Italy assigned to Zambon Group S p A Compounds of formula See Patent for Chemical Structure (I) wherein Rl, R2, R3, R4, and have the meanings reported in the specification, processes for their preparation and pharmaceutical compositions containing them as active ingredient are described. The compounds of formula I are inhibitors of enzymatic systems and they are useful in pharmaceutical field.
5030620 VINBLASTINE DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Jean A A Hannart, Andre B L Trouet, Kandukuri S B Rao, Dion Valmont, Belgium assigned to Omnichem
5028632 TASTE MASKED MEDICATED PHARMACEUTICAL Richard C Fuisz assigned to Fuisz Pharmaceutical Ltd The addition of an extremely small quantity of an anesthetizing agent such as phenol to a medicament dosed saccharide floss serves to numb the taste buds sufficiently that undesirable taste stimulation by the medicament is inhibited.
A description is given of conjugates of vinca alkaloid of the indole-dihydroindole type with a protein or a protein fragment, corresponding to the general formula See Patent for Chemical Structure in which Rl denotes a protein or a protein fragment; R2 is COO(Cl-3 alkyl) or CO-R7 where R7 is NH2 or an amino acid ester or peptide ester; R3 is H, CH3 or CHO; when R5 and R6 are taken separately, R6 is H and one of R4 and R5 is ethyl and the other is H or OH; when R5 and R6 are taken together with the carbon atoms to which they are attached, they form an oxirane ring and R4 is ethyl, and A is a residue of a bifunctional organic derivative of the maleoylamino acid or maleoyl peptide or maleoylphenoxy type.