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5159066 Recombination activating gene (RAG-1)
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New Patents
A plasmid and a DNA fragment each of which contains a gene for tetracycline resistance derived from a glutamic acid-producing coryneform bacterium, and a coryneform bacterium containing said DNA fragment. The gene for tetracycline resistance derived from a glutamic acid-producing coryneform bacterium is a useful selective marker in effecting the breeding of a glutamic acid-producing coryneform bacterium by genetic recombination. Using the plasmid, the DNA fragment or the coryneform bacterium of the present invention, breeding of the glutamic acid-producing coryneform bacterium can be easily and effectively conducted by means of recombinant DNA technique.
5159066
X is oxygen, sulfur, or CH2; Y is a purine or pyrimidine base, and Z is carbon, sulfur, or oxygen. Y can be any purine or pyrimidine base, natural or synthetic, which combines with a sugar to form a biologically active nucleoside. In combination with an appropriate pharmaceutical carrier, the compositions have enhanced activity or increased intracellular absorbment over the parent nucleoside as a function of the S0-diphosphosugar. Another embodiment of the present invention is the enhancement of biologically active nucleosides into cells by preparing and administering the 5’-0diphosphohexose, 5’-diphospho-Nacetylhexosamine or 5’-diphosphohexosamine derivative of the nucleoside. In the preferred embodiment for therapeutic use, the compounds are provided in a pharmaceutical carrier in an amount sufficient to exhibit as known in vitro or in vivo biological activity.
RECOMBINATION ACTIVATING GENE (RAG-l) David Schatz, Marjorie A Oettinger, David Baltimore assigned to Whitehead Institute for Biomedical Research Recombination activating gene of mammalian origin (RAG-l), cDNA of RAG-l of mammalian origin, mRNA expressed by RAG-l, the encoded recombinase and antibodies specific for the recombinase, as well as the use of the same for a diagnostic or therapeutic purpose.
5159068 SEQUENCE OF DNA WHICH CODES MAIN SUBUNITS OF ATP SYNTHASE DERIVED FROM METHANOGENIC BACTERIA Kenichi Inatomi, Masamitsu Futai, Amagasaki, Japan assigned to Mitsubishi Denki Kabushiki Kaisha A DNA sequence, characterized by coding the main subunits of the ATP synthase from methanogenic bacteria.
5159067 5’-DIPHOSPHOHEXOSE NUCLEOSIDE PHARMACEUTICAL COMPOSITIONS Raymond Schinazi, Jean-Pierre Sommadossi, Chum K Chung assigned to University of Georgia Research Foundation Inc; University of Alabama at Birmingham Research Foundation Inc Compounds of the general formula: See Patent for Chemical Structure wherein A, B, and C are hydrogen, halogen, or azido; D is hydrogen, halogen, azido, or OH; A and B or C and D can be replaced with a double bond; R is an aldohexose, aldohexosamine, or N-acetyl aldohexosamine, Rl and R2 are hydrogen or alkyl groups of from C 1 to Cl 0; W is oxygen or sulfur;
5159135 GENETIC ENGINEERING OF COTTON PLANTS AND LINES Paul F Umbeck assigned to Agracetus A method is disclosed to achieve genetic transformation of cotton plants and lines. Immature cotton tissues are genetically transformed in vitro, by Agrobacterium-mediated genetic transformation. The resultant cotton tissues are subjected to a selection agent or agents to screen for transformants. The transformed cultures are then induced to commence somatic emfor possible regime bryogenesis. One regenerating such somatic embryos into whole cotton plants is disclosed.
New Patents
A plasmid and a DNA fragment each of which contains a gene for tetracycline resistance derived from a glutamic acid-producing coryneform bacterium, and a coryneform bacterium containing said DNA fragment. The gene for tetracycline resistance derived from a glutamic acid-producing coryneform bacterium is a useful selective marker in effecting the breeding of a glutamic acid-producing coryneform bacterium by genetic recombination. Using the plasmid, the DNA fragment or the coryneform bacterium of the present invention, breeding of the glutamic acid-producing coryneform bacterium can be easily and effectively conducted by means of recombinant DNA technique.
5159066
X is oxygen, sulfur, or CH2; Y is a purine or pyrimidine base, and Z is carbon, sulfur, or oxygen. Y can be any purine or pyrimidine base, natural or synthetic, which combines with a sugar to form a biologically active nucleoside. In combination with an appropriate pharmaceutical carrier, the compositions have enhanced activity or increased intracellular absorbment over the parent nucleoside as a function of the S0-diphosphosugar. Another embodiment of the present invention is the enhancement of biologically active nucleosides into cells by preparing and administering the 5’-0diphosphohexose, 5’-diphospho-Nacetylhexosamine or 5’-diphosphohexosamine derivative of the nucleoside. In the preferred embodiment for therapeutic use, the compounds are provided in a pharmaceutical carrier in an amount sufficient to exhibit as known in vitro or in vivo biological activity.
RECOMBINATION ACTIVATING GENE (RAG-l) David Schatz, Marjorie A Oettinger, David Baltimore assigned to Whitehead Institute for Biomedical Research Recombination activating gene of mammalian origin (RAG-l), cDNA of RAG-l of mammalian origin, mRNA expressed by RAG-l, the encoded recombinase and antibodies specific for the recombinase, as well as the use of the same for a diagnostic or therapeutic purpose.
5159068 SEQUENCE OF DNA WHICH CODES MAIN SUBUNITS OF ATP SYNTHASE DERIVED FROM METHANOGENIC BACTERIA Kenichi Inatomi, Masamitsu Futai, Amagasaki, Japan assigned to Mitsubishi Denki Kabushiki Kaisha A DNA sequence, characterized by coding the main subunits of the ATP synthase from methanogenic bacteria.
5159067 5’-DIPHOSPHOHEXOSE NUCLEOSIDE PHARMACEUTICAL COMPOSITIONS Raymond Schinazi, Jean-Pierre Sommadossi, Chum K Chung assigned to University of Georgia Research Foundation Inc; University of Alabama at Birmingham Research Foundation Inc Compounds of the general formula: See Patent for Chemical Structure wherein A, B, and C are hydrogen, halogen, or azido; D is hydrogen, halogen, azido, or OH; A and B or C and D can be replaced with a double bond; R is an aldohexose, aldohexosamine, or N-acetyl aldohexosamine, Rl and R2 are hydrogen or alkyl groups of from C 1 to Cl 0; W is oxygen or sulfur;
5159135 GENETIC ENGINEERING OF COTTON PLANTS AND LINES Paul F Umbeck assigned to Agracetus A method is disclosed to achieve genetic transformation of cotton plants and lines. Immature cotton tissues are genetically transformed in vitro, by Agrobacterium-mediated genetic transformation. The resultant cotton tissues are subjected to a selection agent or agents to screen for transformants. The transformed cultures are then induced to commence somatic emfor possible regime bryogenesis. One regenerating such somatic embryos into whole cotton plants is disclosed.