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5175082 Method of characterizing genomic DNA
PATENT ABSTRACTS
5174993 RECOMBINANT AVIPOX VIRUS AND IMMUNOLOGICAL USE THEREOF Enzo Paoletti assigned to Health Research Inc The present invention provides a method for inducing an immunological response in a vertebrate to a pathogen by inoculating the vertebrate with a synthetic recombinant avipox virus modified by the presence, in a non-essential region of the avipox genome, of DNA from any source which codes for and expresses an antigen of the pathogen. The present invention further provides a synthetic recombinant avipox virus modified by the insertion therein of DNA from any source, and particularly from a non-avipox source, into a non-essential region of the avipox genome.
325
Utilizing mouse monoclonal antibodies which recognize Rodgers 1 and Chido 1 epitopes carried on the C4A and C4B molecules, and heat aggregated IgG to activate CI, an immunoassay was developed for the quantitation of complement components, including total C4, C4A and C4B. Interassay variation was 12.4%, 11.5% and 10.8%, respectively. The immunoassay was compared to the quantitation of total C4 by radial immunodiffusion by testing 103 random white controls and gave a Pearson's product moment correlation coefficient of 0.81. Three genetic total C4 deficient individuals were nonreactive in all three assays. This activated assay is specific, reproducible and superior to existing methods for the quantitation of C4A and C4B and detection of the heterozygous C4 null states.
5175095 OVARY-TISSUE TRANSCRIPTIONAL FACTORS
5175082 METHOD
OF CHARACTERIZING GENOMIC DNA
Alec J Jeffreys, Leicester, United Kingdom assigned to Imperial Chemical Industries PLC Test samples of genomic DNA may be characterized by the use of polynucleotide probes each of which is specific for an informative genetic locus. Such probes may be prepared by the use of probes which are capable of differentiating DNA by reference to more than one polymorphic minisatellite region or hypervariable locus. The polynucleotides and probes of the invention are of use for genetic identification purposes, paternity and maternity testing and particularly in forensic medicine.
Belinda M Martineau, Catherine Houck assigned to Calgene Inc Novel DNA constructs are provided which may be used as molecular probes or inserted into a plant host to provide for modification of transcription of a DNA sequence of interest in ovary tissue, particularly in very early fruit development. The DNA constructs comprise a transcriptional initiation regulatory region associated with gene expression in ovary tissue from immediately prior to anthesis through'flower senescence.
5175096 DNA ENCODING A FIBRONECTIN BINDING PROTEIN AS WELL AS ITS PREPARATION
5175083 IMMUNOASSAY FOR THE Q U A N T I T A T I O N O F H U M A N C4 GENE PRODUCTS Joann M Moulds assigned to Board of Regents University of Texas
k Magnus Ho, Klas Jonsson, Kjell M Lindberg, Christer Signas assigned to Alfa-Laval Agri International Aktiebolag The present invention relates to a new recombinant hybrid-DNA-molecule comprising a nucleotide sequence from S. aureus coding for a protein, or polypeptide, having fibronectin binding properties.
5174993 RECOMBINANT AVIPOX VIRUS AND IMMUNOLOGICAL USE THEREOF Enzo Paoletti assigned to Health Research Inc The present invention provides a method for inducing an immunological response in a vertebrate to a pathogen by inoculating the vertebrate with a synthetic recombinant avipox virus modified by the presence, in a non-essential region of the avipox genome, of DNA from any source which codes for and expresses an antigen of the pathogen. The present invention further provides a synthetic recombinant avipox virus modified by the insertion therein of DNA from any source, and particularly from a non-avipox source, into a non-essential region of the avipox genome.
325
Utilizing mouse monoclonal antibodies which recognize Rodgers 1 and Chido 1 epitopes carried on the C4A and C4B molecules, and heat aggregated IgG to activate CI, an immunoassay was developed for the quantitation of complement components, including total C4, C4A and C4B. Interassay variation was 12.4%, 11.5% and 10.8%, respectively. The immunoassay was compared to the quantitation of total C4 by radial immunodiffusion by testing 103 random white controls and gave a Pearson's product moment correlation coefficient of 0.81. Three genetic total C4 deficient individuals were nonreactive in all three assays. This activated assay is specific, reproducible and superior to existing methods for the quantitation of C4A and C4B and detection of the heterozygous C4 null states.
5175095 OVARY-TISSUE TRANSCRIPTIONAL FACTORS
5175082 METHOD
OF CHARACTERIZING GENOMIC DNA
Alec J Jeffreys, Leicester, United Kingdom assigned to Imperial Chemical Industries PLC Test samples of genomic DNA may be characterized by the use of polynucleotide probes each of which is specific for an informative genetic locus. Such probes may be prepared by the use of probes which are capable of differentiating DNA by reference to more than one polymorphic minisatellite region or hypervariable locus. The polynucleotides and probes of the invention are of use for genetic identification purposes, paternity and maternity testing and particularly in forensic medicine.
Belinda M Martineau, Catherine Houck assigned to Calgene Inc Novel DNA constructs are provided which may be used as molecular probes or inserted into a plant host to provide for modification of transcription of a DNA sequence of interest in ovary tissue, particularly in very early fruit development. The DNA constructs comprise a transcriptional initiation regulatory region associated with gene expression in ovary tissue from immediately prior to anthesis through'flower senescence.
5175096 DNA ENCODING A FIBRONECTIN BINDING PROTEIN AS WELL AS ITS PREPARATION
5175083 IMMUNOASSAY FOR THE Q U A N T I T A T I O N O F H U M A N C4 GENE PRODUCTS Joann M Moulds assigned to Board of Regents University of Texas
k Magnus Ho, Klas Jonsson, Kjell M Lindberg, Christer Signas assigned to Alfa-Laval Agri International Aktiebolag The present invention relates to a new recombinant hybrid-DNA-molecule comprising a nucleotide sequence from S. aureus coding for a protein, or polypeptide, having fibronectin binding properties.