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5196333 DNA sequences involved in neuronal degeneration, multicellular organisms containing same and uses thereof
121
PATENT ABSTRACI~
5196328 MODIFIED CLONING VECTORS FOR RESTRICTION MAPPING, THEIR PREPARATION AND USE Kenneth Tartof assigned to Institute for Cancer Research
known as Pine I, recognizes the following nucleotide sequence and has a cleavage point indicated by the arrows: 5'-G T T T down arrowA A A C-3' 3'-C A A A up arruwT T T G-5' Also described is a process for obtaining Pine I from Pseudomonas mendocina.
5196331
Modified cloning vectors having general utility for easily obtaining unambiguous restriction maps of recombinant DNA molecules and the methods of preparation and use of such vectors.
CLONING THE MSPI RESTRICTION AND MODIFICATION GENES
5196329
Geoffrey G Wilson assigned to New England Biolabs Inc
780 T - D N A G E N E TRANSCRIPTION ACTIVATOR William Gurley, Wesley B Bruce assigned to Lubrizol Genetics Inc; The University of Flori A DNA sequence element, which activates or enhances expression of genes in plants has been identified and characterized. In particular, DNA segments isolated from the upstream region of the T-DNA 780 gene are capable of activating or increasing transcription levels of plantexpressible genes in recombinant DNAcontaining plant tissue. The 780 gene transcription activator is useful in general for increasing the level of expression of a gene in a plant. In particular, such activators are useful in the construction of plant-expression complexes which contain a plant-expressible gene placed under the regulatory control of the activator. Such expression complexes can be introduced into plant tissue where the inserted gene is expressed.
5196330 T Y P E II R E S T R I C T I O N E N D O N U C L E A S E , P M E I, OBTAINABLE FROM PSEUDOMONAS MENDOCINA AND A PROCESS FOR PRODUCING THE SAME Richard Morgan, Bing Zhou, Cologne, assigned to New England Biolabs Inc The present invention provides a novel type II restriction endonuclease obtainable from Pseudomonas mendocina. The endonuclease
Methods for cloning restriction enzymes and their corresponding modification enzymes by selecting clones resistant to in vitro digestion by the restriction enzyme and subsequent screening to identify those clones containing the restriction gene.
5196332 CLONING THE HAE H RESTRICTION AND MODIFICATION GENES Geoffrey G Wilson assigned to New England Biolabs Inc Methods for cloning restriction enzymes and their corresponding modification enzymes by selecting clones resistant to in vitro digestion by the restriction enzyme and subsequent screening to identify those clones containing the restriction gene.
5196333 DNA SEQUENCES INVOLVED IN NEURONAL DEGENERATION, MULTICELLULAR ORGANISMS CONTAINING SAME AND USES THEREOF Matin Chalfie, Eve Wolinsky, Monica Driscoil assigned to The Trustees of Columbia University This invention provides an isolated nucleic acid molecule encoding a wild-type animal protein associated with neuronal degeneration and an isolated nucleic acid molecule encoding a
122
PATENT ABSTRACTS
mutated animal protein associated with neuronal degeneration. Also provided are strains of the nematode Caenorhabditis elegans containing the nucleic acid molecules encoding a mutated C. elegans protein associated with neuronal degeneration. The invention also provides methods for detecting such nucleic acid molecules, for diagnosing degenerative disease, for causing a diseased human cell to degenerate, and for screening drugs to identify drugs which prevent or decrease neuronal degeneration.
5196335 HUMAN SUPEROXIDE DISMUTASE CDNA Yoram Groner, Rehovot, Israel assigned to Yeda Research and Development Co Ltd A double-stranded eDNA molecule which includes DNA encoding human cytoplasmic superoxide dismutase has been created. The sequence of one strand of a double-stranded DNA molecule which encodes human cytoplasmic superoxide dismutase has been discovered. Such molecules may be introduced in procaryotic, e.g., bacterial, or eucaryotic, e.g., yeast or mammalian, cells and the resulting cells cultured or grown under suitable conditions so as to produce human cytoplasmic superoxide dismutase which may then be recovered.
such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides, proteins, and fusion proteins in appropriate host ceils. The peptides, proteins, fusion proteins and viruses both live and inactivated are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides, proteins and fusion proteins are also used as reagents in immunoassays as well as to prepare.immunoglobulins for passive immunization. Use of the nucleotide sequences encoding the PBOMP related peptides, proteins and fusion proteins in hybridization assays is also described.
51~M2 BACILLUS THURINGIENSIS TOXIN GENE
P-2
William Donovan assigned to PruTech R&D Partnership II This invention relates to a crystalline protein toxin useful as a biological insecticide which is known as P-2 toxin, or P-2 delta-endotoxin and which is produced by Bacillus thuringiensis. More specifically, this invention relates to the cloning and expression in various microorganisms of the gene coding for the P-2 deltaendotoxin.
5196403 5196338 RECOMBINANT VECTORS FOR HAEMOPHILUS INFLUENZAE PElrI'IDES AND PROTEINS Algis Anilionis, Robert C Seid, Robert Deich, Gary W Zlotnick, Bruce Green assigned to Praxis Biologics Inc Peptides and proteins related to an epitope c0mprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and improved methods of purification from H. influenzae cultures, and by recombinant D N A and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP1 and PBOMP-2 related peptides, proteins and fusion proteins are also described. Recombinant vectors include plasmid D N A and viral D N A
METHOD OF INHIBITING PLATELET ACTIVATION John Maraganore, Joseph Jakubowski, Betty H Chao assigned to Biogen Inc; Trustees of Boston University PCT No. PCT/US90/00465 Sec. 371 Date Jul. 23, 1991 Sec. 102(e)Date Jul. 23, 1991 PCT Filed Jan. 26, 1990.The present invention relates to polypeptide inhibitors of platelet activation and derivatives thereof, purified from the venom of the North American Water Moccasin and to methods for their purification. This invention also relates to DNA sequences and recombinant D N A molecules which code for these polypeptide inhibitors ofplatelet activation. And this invention relates to recombinant D N A molecules which code for fusion proteins comprising both a polypeptide inhibitor of platelet activation and a conventional anti-thrombin
PATENT ABSTRACI~
5196328 MODIFIED CLONING VECTORS FOR RESTRICTION MAPPING, THEIR PREPARATION AND USE Kenneth Tartof assigned to Institute for Cancer Research
known as Pine I, recognizes the following nucleotide sequence and has a cleavage point indicated by the arrows: 5'-G T T T down arrowA A A C-3' 3'-C A A A up arruwT T T G-5' Also described is a process for obtaining Pine I from Pseudomonas mendocina.
5196331
Modified cloning vectors having general utility for easily obtaining unambiguous restriction maps of recombinant DNA molecules and the methods of preparation and use of such vectors.
CLONING THE MSPI RESTRICTION AND MODIFICATION GENES
5196329
Geoffrey G Wilson assigned to New England Biolabs Inc
780 T - D N A G E N E TRANSCRIPTION ACTIVATOR William Gurley, Wesley B Bruce assigned to Lubrizol Genetics Inc; The University of Flori A DNA sequence element, which activates or enhances expression of genes in plants has been identified and characterized. In particular, DNA segments isolated from the upstream region of the T-DNA 780 gene are capable of activating or increasing transcription levels of plantexpressible genes in recombinant DNAcontaining plant tissue. The 780 gene transcription activator is useful in general for increasing the level of expression of a gene in a plant. In particular, such activators are useful in the construction of plant-expression complexes which contain a plant-expressible gene placed under the regulatory control of the activator. Such expression complexes can be introduced into plant tissue where the inserted gene is expressed.
5196330 T Y P E II R E S T R I C T I O N E N D O N U C L E A S E , P M E I, OBTAINABLE FROM PSEUDOMONAS MENDOCINA AND A PROCESS FOR PRODUCING THE SAME Richard Morgan, Bing Zhou, Cologne, assigned to New England Biolabs Inc The present invention provides a novel type II restriction endonuclease obtainable from Pseudomonas mendocina. The endonuclease
Methods for cloning restriction enzymes and their corresponding modification enzymes by selecting clones resistant to in vitro digestion by the restriction enzyme and subsequent screening to identify those clones containing the restriction gene.
5196332 CLONING THE HAE H RESTRICTION AND MODIFICATION GENES Geoffrey G Wilson assigned to New England Biolabs Inc Methods for cloning restriction enzymes and their corresponding modification enzymes by selecting clones resistant to in vitro digestion by the restriction enzyme and subsequent screening to identify those clones containing the restriction gene.
5196333 DNA SEQUENCES INVOLVED IN NEURONAL DEGENERATION, MULTICELLULAR ORGANISMS CONTAINING SAME AND USES THEREOF Matin Chalfie, Eve Wolinsky, Monica Driscoil assigned to The Trustees of Columbia University This invention provides an isolated nucleic acid molecule encoding a wild-type animal protein associated with neuronal degeneration and an isolated nucleic acid molecule encoding a
122
PATENT ABSTRACTS
mutated animal protein associated with neuronal degeneration. Also provided are strains of the nematode Caenorhabditis elegans containing the nucleic acid molecules encoding a mutated C. elegans protein associated with neuronal degeneration. The invention also provides methods for detecting such nucleic acid molecules, for diagnosing degenerative disease, for causing a diseased human cell to degenerate, and for screening drugs to identify drugs which prevent or decrease neuronal degeneration.
5196335 HUMAN SUPEROXIDE DISMUTASE CDNA Yoram Groner, Rehovot, Israel assigned to Yeda Research and Development Co Ltd A double-stranded eDNA molecule which includes DNA encoding human cytoplasmic superoxide dismutase has been created. The sequence of one strand of a double-stranded DNA molecule which encodes human cytoplasmic superoxide dismutase has been discovered. Such molecules may be introduced in procaryotic, e.g., bacterial, or eucaryotic, e.g., yeast or mammalian, cells and the resulting cells cultured or grown under suitable conditions so as to produce human cytoplasmic superoxide dismutase which may then be recovered.
such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides, proteins, and fusion proteins in appropriate host ceils. The peptides, proteins, fusion proteins and viruses both live and inactivated are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides, proteins and fusion proteins are also used as reagents in immunoassays as well as to prepare.immunoglobulins for passive immunization. Use of the nucleotide sequences encoding the PBOMP related peptides, proteins and fusion proteins in hybridization assays is also described.
51~M2 BACILLUS THURINGIENSIS TOXIN GENE
P-2
William Donovan assigned to PruTech R&D Partnership II This invention relates to a crystalline protein toxin useful as a biological insecticide which is known as P-2 toxin, or P-2 delta-endotoxin and which is produced by Bacillus thuringiensis. More specifically, this invention relates to the cloning and expression in various microorganisms of the gene coding for the P-2 deltaendotoxin.
5196403 5196338 RECOMBINANT VECTORS FOR HAEMOPHILUS INFLUENZAE PElrI'IDES AND PROTEINS Algis Anilionis, Robert C Seid, Robert Deich, Gary W Zlotnick, Bruce Green assigned to Praxis Biologics Inc Peptides and proteins related to an epitope c0mprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and improved methods of purification from H. influenzae cultures, and by recombinant D N A and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP1 and PBOMP-2 related peptides, proteins and fusion proteins are also described. Recombinant vectors include plasmid D N A and viral D N A
METHOD OF INHIBITING PLATELET ACTIVATION John Maraganore, Joseph Jakubowski, Betty H Chao assigned to Biogen Inc; Trustees of Boston University PCT No. PCT/US90/00465 Sec. 371 Date Jul. 23, 1991 Sec. 102(e)Date Jul. 23, 1991 PCT Filed Jan. 26, 1990.The present invention relates to polypeptide inhibitors of platelet activation and derivatives thereof, purified from the venom of the North American Water Moccasin and to methods for their purification. This invention also relates to DNA sequences and recombinant D N A molecules which code for these polypeptide inhibitors ofplatelet activation. And this invention relates to recombinant D N A molecules which code for fusion proteins comprising both a polypeptide inhibitor of platelet activation and a conventional anti-thrombin