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4476042 Mono-oxomethyl substituted polyhydro-dimethanonaphthalene derivatives, organoleptic uses thereof and processes for preparing same
110
PATENT ABSTRACTS
4476042
Healthcare Products
4472302 HEAT SHOCK P R O C E S S FOR THE ISOLATION OF BACTERIAL PROTEIN Yashwant Karkhanis assigned to Merck & Co Inc There is disclosed an improved process for the isolation of K-99 outer membrane protein pili from Escherichia coli cells. The improved process involves a heat shock treatment of the E. coli cells in a buffered solution to afford a release of the K-99 pill into solution which on standing results in the aggregation and precipitation of the pili. The thus isolated K-99 protein pili is useful in the preparation of vaccines.
MONO-OXOMETHYL SUBSTITUTED POLYHYDRODIMETHANONAPHTHALENE DERIVATIVES, ORGANOLEPTIC USES THEREOF AND PROCESSES FOR PREPARING SAME Mark A Sprecker, Marie Hanna, Richard J Tokarzewski, Robert P Belko, Hugh Watkins, Manfred H Vock assigned to International Flavors & Fragrances Inc RI" R¢~.' RL
R5 ....
t
R3
Rd
R5
RS"'
Z
I%6
4472378 LIVE VACCINE FOR THE P R E V E N T I O N OF SALMONELLOSIS IN WATER F O W L , A P R O C E S S FOR M A K I N G AND APPLYING THE SAME Boris Shuster, Jury Malakhov, Fedor Kirzhaev, Arkady Persov, Vladimir Sedov, Anatoly Kosikov, Vyacheslav Guschin, Vladimir Likhoded, Moscow, Union Of Soviet Socialist Republics A novel live vaccine for the prevention of salmonellosis in water fowl comprising essentially a suspension of living culture of the attenuated strain Salmonella typhi-murium No. 3, deposited at the All-Union State Research Control Institute for Veterinary Preparations, the USSR Ministry of Agriculture (No. 121), in a concentration of 2-4 billion microbe cells per 10 cm3 of drinking water. A process for making said vaccine, wherein the attenuated strain Salmonella typhi-murium No. 3 is cultivated in a culture medium containing sources of carbon, nitrogen, mineral salts, biologically active substances at a temperature of 37 degrees-38 degrees C. to produce the highest attainable accumulation of biomass during a period of 10-14 hours with subsequent drying and obtainment of the vaccine. A method of specific prophylaxis of salmonellosis in water fowl, wherein the live vaccine is administered to the poultry twice orally at a 23 days interval in a dose of 2 billion microbe cells at the first, and 4 billion microbe cells at the second, feeding, being combined with drinking water.
Described are mono-oxomethyl substituted polyhydrodimethanonaphthalene derivatives having the generic structure: See Patent .for Chemical Structure wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond; wherein R1, RI', RI", RI'", RI'"', R3, R5, R5",R5", R5'", R5 .... and R6 represents hydrogen or methyl with the provisos: (i) at least four of RI, RI', Rl", RI"' and R I ' " ' are hydrogen; and (ii) at least four of R5, R5', R5", R5'" and R5'"' represent hydrogen; and wherein Z represents one of the moieties: (i) carboxaldehyde having the structure: See Patent for Chemical Structure (ii) alkylene dioxy or dialkoxy methyl having the structure: See PatentJor Chemical Structure (iii) hydroxy methyl having the structure: See Patent Jor Chemical Structure (iv) acetoxymethyl having the structure: See Patent.[or Chemical Structure and wherein R7 and R8 taken separately represent C1-C4 lower alkyl or R7 and R8 taken together represent C2-C4 alkylene; wherein the line represented by: See Patent for Tabular Presentation PS is either (i) a carboncarbon single bond when R7 and R8 taken together are C2-C4 alkylene or (ii) no bond at all when R7 and R8 taken separately represent C1C4 lower alkyl. Also described are processes for preparing such mono-oxomethyl substituted polyhydrodimethanonaphthalene derivatives, and processes for using the above defined mono-
PATENT A B S T R A C T S
oxomethyl substituted polyhydrodimethanonaphthalene derivatives for their organoleptic properties and compositions containing said mono-oxomethyl substituted polyhydrodimethanonaphthalene derivatives including perfumes, perfumed articles (such as solid or liquid anionic, cationic, nonionic or zwitterionic detergents, perfumed polymers, fabric softeners and cosmetic powders), foodstuffs, chewing gums, toothpastes, medicinal products, chewing tobaccos, smoking tobaccos and smoking tobacco articles.
111
4476301 OLIGONUCLEOTIDES, A PROCESS FOR PREPARING THE SAME AND THEIR APPLICATION AS MEDIATORS OF THE ACTION OF INTERFERON Jean-Louis Imbach, Gilles J M Gosselin, Montpellier, France assigned to Centre National de la Recherche Scientifique The invention relates to new oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon.
4476109 METHOD OF PREPARING GAMMA GLOBULIN SUITABLE FOR INTRAVENOUS ADMINISTRATION Tokusuk Kimura, Fumio Karosu, Toshitsugu Inouchi, Masana Komatsu, Tokyo, Japan assigned to Fujirebio Kabushiki Kaisha A method of preparing gamma globulin suitable for intravenous administration comprising a first step of treating a supernatant liquid separated from human blood plasma with ethanol under conditions ofa pH of 5,5 to 6.5, an ethanol concentration of 30 to 35~o, and a protein concentration of 1 to 2% by weight.
4477432 ORAL IMMUNE W Richar Hardie Laboratories Inc
GLOBULIN assigned
to
Cutter
There is disclosed an oral pharmaceutical composition for therapeutic use comprising a therapeutically effective amount of orally administerable immune globulin in a pharmaceutically acceptable carrier.
4477468 T R E A T M E N T O F T Y P E II HERPES VIRUS WITH FLURBIPROFEN
4476139
Jay W Heckler assigned to The Upjohn Company
DISCOVERY OF ANTIBIOTIC L-681,217 IN FERMENTATION BROTH August Kempf, Kenneth Wilson, Otto D Hensens, Richard Monaghan, Sheldon B Zimmerman, Eugene L Dulaney assigned to Merck & Co lnc
A process for treating Herpes Type I1 virus by the systemic administration or topical application of flurbiprofen (3-fluoro-4phenylhydratropic acid) or a salt or ester thereof. Dosage forms are also disclosed.
4478744 OH
H OMe
~¢HO
N --
I O OH
OH
0 OH
MeMe
The antibiotic, L-681,217, having antibacterial and growth-permittant activity, is produced by fermentation of Streptomyees cattleya in a suitable nutrient media.
METHOD OF OBTAINING ANTIBODIES Louis Mezei, Jung S Chen, John Huang, Robert E Lovins assigned to Sherwood Medical Company Antibodies specific to glycosylated hemoglobin and substantially free of cross-reactivity with nonglycosylated forms of hemoglobin are ob-
PATENT ABSTRACTS
4476042
Healthcare Products
4472302 HEAT SHOCK P R O C E S S FOR THE ISOLATION OF BACTERIAL PROTEIN Yashwant Karkhanis assigned to Merck & Co Inc There is disclosed an improved process for the isolation of K-99 outer membrane protein pili from Escherichia coli cells. The improved process involves a heat shock treatment of the E. coli cells in a buffered solution to afford a release of the K-99 pill into solution which on standing results in the aggregation and precipitation of the pili. The thus isolated K-99 protein pili is useful in the preparation of vaccines.
MONO-OXOMETHYL SUBSTITUTED POLYHYDRODIMETHANONAPHTHALENE DERIVATIVES, ORGANOLEPTIC USES THEREOF AND PROCESSES FOR PREPARING SAME Mark A Sprecker, Marie Hanna, Richard J Tokarzewski, Robert P Belko, Hugh Watkins, Manfred H Vock assigned to International Flavors & Fragrances Inc RI" R¢~.' RL
R5 ....
t
R3
Rd
R5
RS"'
Z
I%6
4472378 LIVE VACCINE FOR THE P R E V E N T I O N OF SALMONELLOSIS IN WATER F O W L , A P R O C E S S FOR M A K I N G AND APPLYING THE SAME Boris Shuster, Jury Malakhov, Fedor Kirzhaev, Arkady Persov, Vladimir Sedov, Anatoly Kosikov, Vyacheslav Guschin, Vladimir Likhoded, Moscow, Union Of Soviet Socialist Republics A novel live vaccine for the prevention of salmonellosis in water fowl comprising essentially a suspension of living culture of the attenuated strain Salmonella typhi-murium No. 3, deposited at the All-Union State Research Control Institute for Veterinary Preparations, the USSR Ministry of Agriculture (No. 121), in a concentration of 2-4 billion microbe cells per 10 cm3 of drinking water. A process for making said vaccine, wherein the attenuated strain Salmonella typhi-murium No. 3 is cultivated in a culture medium containing sources of carbon, nitrogen, mineral salts, biologically active substances at a temperature of 37 degrees-38 degrees C. to produce the highest attainable accumulation of biomass during a period of 10-14 hours with subsequent drying and obtainment of the vaccine. A method of specific prophylaxis of salmonellosis in water fowl, wherein the live vaccine is administered to the poultry twice orally at a 23 days interval in a dose of 2 billion microbe cells at the first, and 4 billion microbe cells at the second, feeding, being combined with drinking water.
Described are mono-oxomethyl substituted polyhydrodimethanonaphthalene derivatives having the generic structure: See Patent .for Chemical Structure wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond; wherein R1, RI', RI", RI'", RI'"', R3, R5, R5",R5", R5'", R5 .... and R6 represents hydrogen or methyl with the provisos: (i) at least four of RI, RI', Rl", RI"' and R I ' " ' are hydrogen; and (ii) at least four of R5, R5', R5", R5'" and R5'"' represent hydrogen; and wherein Z represents one of the moieties: (i) carboxaldehyde having the structure: See Patent for Chemical Structure (ii) alkylene dioxy or dialkoxy methyl having the structure: See PatentJor Chemical Structure (iii) hydroxy methyl having the structure: See Patent Jor Chemical Structure (iv) acetoxymethyl having the structure: See Patent.[or Chemical Structure and wherein R7 and R8 taken separately represent C1-C4 lower alkyl or R7 and R8 taken together represent C2-C4 alkylene; wherein the line represented by: See Patent for Tabular Presentation PS is either (i) a carboncarbon single bond when R7 and R8 taken together are C2-C4 alkylene or (ii) no bond at all when R7 and R8 taken separately represent C1C4 lower alkyl. Also described are processes for preparing such mono-oxomethyl substituted polyhydrodimethanonaphthalene derivatives, and processes for using the above defined mono-
PATENT A B S T R A C T S
oxomethyl substituted polyhydrodimethanonaphthalene derivatives for their organoleptic properties and compositions containing said mono-oxomethyl substituted polyhydrodimethanonaphthalene derivatives including perfumes, perfumed articles (such as solid or liquid anionic, cationic, nonionic or zwitterionic detergents, perfumed polymers, fabric softeners and cosmetic powders), foodstuffs, chewing gums, toothpastes, medicinal products, chewing tobaccos, smoking tobaccos and smoking tobacco articles.
111
4476301 OLIGONUCLEOTIDES, A PROCESS FOR PREPARING THE SAME AND THEIR APPLICATION AS MEDIATORS OF THE ACTION OF INTERFERON Jean-Louis Imbach, Gilles J M Gosselin, Montpellier, France assigned to Centre National de la Recherche Scientifique The invention relates to new oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon.
4476109 METHOD OF PREPARING GAMMA GLOBULIN SUITABLE FOR INTRAVENOUS ADMINISTRATION Tokusuk Kimura, Fumio Karosu, Toshitsugu Inouchi, Masana Komatsu, Tokyo, Japan assigned to Fujirebio Kabushiki Kaisha A method of preparing gamma globulin suitable for intravenous administration comprising a first step of treating a supernatant liquid separated from human blood plasma with ethanol under conditions ofa pH of 5,5 to 6.5, an ethanol concentration of 30 to 35~o, and a protein concentration of 1 to 2% by weight.
4477432 ORAL IMMUNE W Richar Hardie Laboratories Inc
GLOBULIN assigned
to
Cutter
There is disclosed an oral pharmaceutical composition for therapeutic use comprising a therapeutically effective amount of orally administerable immune globulin in a pharmaceutically acceptable carrier.
4477468 T R E A T M E N T O F T Y P E II HERPES VIRUS WITH FLURBIPROFEN
4476139
Jay W Heckler assigned to The Upjohn Company
DISCOVERY OF ANTIBIOTIC L-681,217 IN FERMENTATION BROTH August Kempf, Kenneth Wilson, Otto D Hensens, Richard Monaghan, Sheldon B Zimmerman, Eugene L Dulaney assigned to Merck & Co lnc
A process for treating Herpes Type I1 virus by the systemic administration or topical application of flurbiprofen (3-fluoro-4phenylhydratropic acid) or a salt or ester thereof. Dosage forms are also disclosed.
4478744 OH
H OMe
~¢HO
N --
I O OH
OH
0 OH
MeMe
The antibiotic, L-681,217, having antibacterial and growth-permittant activity, is produced by fermentation of Streptomyees cattleya in a suitable nutrient media.
METHOD OF OBTAINING ANTIBODIES Louis Mezei, Jung S Chen, John Huang, Robert E Lovins assigned to Sherwood Medical Company Antibodies specific to glycosylated hemoglobin and substantially free of cross-reactivity with nonglycosylated forms of hemoglobin are ob-