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5252720 Metal complexes of water soluble texaphyrins
New Patents
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such signals, i.e. adding opposing responses together to suppress the fat response.
5250900 NMR INVESTIGATION OF REPEATED ELECTROMAGNETIC EVENTS Gosta J Ehnholm, Helsinki, Finland assigned to Instrumentarium Corporation A method of nuclear magnetic resonance investigation of a repeated electromagnetic event in a sample comprises modulation of the nuclear spin polarization achieved during the recovery period between the final magnetic resonance signal detection period of one cycle and the initial signal generation RF pulse of the next cycle. This modulation is performed by giving the sample a different exposure to RF radiation in the different periods, for example by exposure to a different number of 180 degrees pulses in each period or by exposure to a frequency modulated continuous wave RF signal.
5251628 VARIABLE ECG DELAY IN FAST PULSE SEQUENCE SCANS Thomas K Foo assigned to General Electric Company An NMR system performs a pulmonary vascular scan comprised of a series of slice acquisition. Each slice acquisition employs a series of fast pulse sequences (GRASS) which are completed in one cardiac cycle. The view order of each slice acquisition is altered such that the low order views are acquired at a desired contrast delay interval after receipt of a cardiac trigger signal.
5251629 INSPECTION METHOD AND APPARATUS UTILIZING NUCLEAR MAGNETIC RESONANCE Hideaki Koizumi, Kazuya Sukegawa, Katsuta, Japan assigned to Hitachi Ltd
A method of and an apparatus for inspecting a physical portion having physiological movement, for example, the abdominal region moving with breathing, by utilizing nuclear magnetic resonance. The circumstances of that area of the surface of the abdominal region which exists on a plane indicative of a slice to be imaged, is made different from the circumstances of the surface of the remaining physical portion. In this case, a person to be inspected feels a foreign matter at the abdominal region, and suppresses the movement of the abdominal region due to breathing, consciously and unconsciously, thereby moving the breast with breathing. Thus, the to-beinspected abdominal region is kept quiet, and an accurate inspection can be made in a short period of time.
5252720 METAL COMPLEXES OF WATER SOLUBLE TEXAPHYRINS Jonathan L Sessler, Gregory W Hemmi, Tarak D Mody assigned to Board of Regents The University of Texas System The present invention involves water soluble hydroxy-substituted texaphyrins retaining lipophilicity, the synthesis of such compounds and their uses. These expanded porphyrin-like macrocycles are efficient chelators of divalent and trivalent metal ions. Various metal (e.g., transition, main group, and lanthanide) complexes of the hydroxy-substituted texaphyrin derivatives of the present invention have unusual water solubility and stability. They absorb light strongly in a physiologically important region (i.e. 690-880 nm). They have enhanced relaxivity and therefore are useful in magnetic resonance imaging. They form long-lived triplet states in high yield and act as photosensitizers for the generation of singlet oxygen. Thus, they are useful for inactivation or destruction of human immunodeficiency virus (HIV-l), mononuclear or other cells infected with such virus as well as tumor cells. They are water soluble, yet they retain sufficient lipophilicity so as to have greater affinity for lipid rich areas such as atheroma and tumors. They may be used for magnetic resonance imaging followed by photodynamic tumor therapy in the treatment of atheroma and tumors. These properties, coupled with their high chemical stability and appreciable solubility in water, add to their usefulness.
XXII
such signals, i.e. adding opposing responses together to suppress the fat response.
5250900 NMR INVESTIGATION OF REPEATED ELECTROMAGNETIC EVENTS Gosta J Ehnholm, Helsinki, Finland assigned to Instrumentarium Corporation A method of nuclear magnetic resonance investigation of a repeated electromagnetic event in a sample comprises modulation of the nuclear spin polarization achieved during the recovery period between the final magnetic resonance signal detection period of one cycle and the initial signal generation RF pulse of the next cycle. This modulation is performed by giving the sample a different exposure to RF radiation in the different periods, for example by exposure to a different number of 180 degrees pulses in each period or by exposure to a frequency modulated continuous wave RF signal.
5251628 VARIABLE ECG DELAY IN FAST PULSE SEQUENCE SCANS Thomas K Foo assigned to General Electric Company An NMR system performs a pulmonary vascular scan comprised of a series of slice acquisition. Each slice acquisition employs a series of fast pulse sequences (GRASS) which are completed in one cardiac cycle. The view order of each slice acquisition is altered such that the low order views are acquired at a desired contrast delay interval after receipt of a cardiac trigger signal.
5251629 INSPECTION METHOD AND APPARATUS UTILIZING NUCLEAR MAGNETIC RESONANCE Hideaki Koizumi, Kazuya Sukegawa, Katsuta, Japan assigned to Hitachi Ltd
A method of and an apparatus for inspecting a physical portion having physiological movement, for example, the abdominal region moving with breathing, by utilizing nuclear magnetic resonance. The circumstances of that area of the surface of the abdominal region which exists on a plane indicative of a slice to be imaged, is made different from the circumstances of the surface of the remaining physical portion. In this case, a person to be inspected feels a foreign matter at the abdominal region, and suppresses the movement of the abdominal region due to breathing, consciously and unconsciously, thereby moving the breast with breathing. Thus, the to-beinspected abdominal region is kept quiet, and an accurate inspection can be made in a short period of time.
5252720 METAL COMPLEXES OF WATER SOLUBLE TEXAPHYRINS Jonathan L Sessler, Gregory W Hemmi, Tarak D Mody assigned to Board of Regents The University of Texas System The present invention involves water soluble hydroxy-substituted texaphyrins retaining lipophilicity, the synthesis of such compounds and their uses. These expanded porphyrin-like macrocycles are efficient chelators of divalent and trivalent metal ions. Various metal (e.g., transition, main group, and lanthanide) complexes of the hydroxy-substituted texaphyrin derivatives of the present invention have unusual water solubility and stability. They absorb light strongly in a physiologically important region (i.e. 690-880 nm). They have enhanced relaxivity and therefore are useful in magnetic resonance imaging. They form long-lived triplet states in high yield and act as photosensitizers for the generation of singlet oxygen. Thus, they are useful for inactivation or destruction of human immunodeficiency virus (HIV-l), mononuclear or other cells infected with such virus as well as tumor cells. They are water soluble, yet they retain sufficient lipophilicity so as to have greater affinity for lipid rich areas such as atheroma and tumors. They may be used for magnetic resonance imaging followed by photodynamic tumor therapy in the treatment of atheroma and tumors. These properties, coupled with their high chemical stability and appreciable solubility in water, add to their usefulness.