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5569759 Water soluble texaphyrin metal complex preparation
XIV
Patents
a single superconductive coil assembly including a toroidal-shaped coil housing containing a pair of superconductive main coils. A pair of generally annular-shaped bucking coils, carrying electric current in a direction opposite to that of the superconductive main coils, is spaced radially inward and apart from the superconductive main coils. The bucking coils allow the design of a shorter MRI magnet because the bucking coils overcome the gross magnetic field distortions in the imaging volume of the magnet (created by removing some of the additional longitudinally-outermost superconductive main coils, otherwise used in the magnet, to make the magnet shorter) to produce a magnetic field of high uniformity within the imaging volume.
5569266 MAGNETIC RESONANCE IMAGING DEVICE USEFUL FOR GUIDING A MEDICAL INSTRUMENT Siczek Bernard Boulder, CO, UNITED assigned to Fischer Imaging Corporation
ALERT
hydroxy-substituted texaphyrins retaining lipophilicity, the synthesis of such compounds and their uses. These expanded porphyrin-like macrocycles are efficient chelators of divalent and trivalent metal ions. Various metal (e.g., transition, main group, and lanthanide) complexes of the hydroxy-substituted texaphyrin derivatives of the present invention have unusual water solubility and stability. They absorb light strongly in a physiologically important region (i.e. 690-880 nm). They have enhanced relaxivity and therefore are useful in magnetic resonance imaging. They form long-lived triplet states in high yield and act as photosensitizers for the generation of singlet oxygen. Thus, they are useful for inactivation or destruction of enveloped viruses, mononuclear or other cells infected with such viruses as well as tumor cells. They are water soluble, yet they retain sufficient lipophilicity so as to have greater affinity for lipid rich areas such as atheroma and tumors. They may be used for magnetic resonance imaging followed by photodynamic tumor therapy in the treatment of atheroma and tumors. These properties, coupled with their high chemical stability and appreciable solubility in water, add to their usefulness.
STATES
5570018 The disclosed system employs an MRI device to identify the location of an area of interest within a patient’s breast and guide a medical instrument for insertion to the identified location. The patient is positioned on a table top having an opening through which the patient’s breast pendulantly projects. The pendulant breast is immobilized by a basket. The table top and patient are then introduced into magnetic field generator and MRl signals are received by receiver. The location of an area of interest within the patient’s breast is determined based on the received signals. A guidance assembly can then be used to aim the medical instrument towards the location of interest via a penetration path selected so as to avoid the receiver and basket.
5569759 WATER SOLUBLE TEXAPHYRIN METAL COMPLEX PREPARATION Sessler Jonathan L; Hemmi Gregory W; Mody Tarak D Austin, TX, UNITED STATES assigned to Board of Regents University of Texas System The
present
invention
involves
water
soluble
METHOD OF AND APPARATUS FOR OBTAINING SPATIAL NMR INFORMATION Halse Roger Beltinge, UNITED KINGDOM British Technology Group Limited
assigned to
PCT No. PCT/GB93/00052 Sec. 371 Date Jun. 2, 1994 Sec. 102(e) Date Jun. 2, 1994 PCT Filed Jan. 12, 1993 PCT Pub. No. WO93/14416 PCT Pub. Date Jul. 22, 1993. Spatial NMR information is obtained from a sample by applying a magnetic field having a static component and two sinusoidally time varying gradient components (Gy, Gz), the period of one gradient component (Gz) being preferably twice the period of the other gradient component (Gy). An RF excitation pulse is applied at the instant both gradient field components are zero. A plurality of NMR sampling responses are produced by gradient echoes in data capture windows and the amplitudes of the gradient field components are varied to provide a desired distribution of sampling path in k-space in each data capture window the gradient field components are reversed in direction to enable all quadrants of k-space to be sampled.
Patents
a single superconductive coil assembly including a toroidal-shaped coil housing containing a pair of superconductive main coils. A pair of generally annular-shaped bucking coils, carrying electric current in a direction opposite to that of the superconductive main coils, is spaced radially inward and apart from the superconductive main coils. The bucking coils allow the design of a shorter MRI magnet because the bucking coils overcome the gross magnetic field distortions in the imaging volume of the magnet (created by removing some of the additional longitudinally-outermost superconductive main coils, otherwise used in the magnet, to make the magnet shorter) to produce a magnetic field of high uniformity within the imaging volume.
5569266 MAGNETIC RESONANCE IMAGING DEVICE USEFUL FOR GUIDING A MEDICAL INSTRUMENT Siczek Bernard Boulder, CO, UNITED assigned to Fischer Imaging Corporation
ALERT
hydroxy-substituted texaphyrins retaining lipophilicity, the synthesis of such compounds and their uses. These expanded porphyrin-like macrocycles are efficient chelators of divalent and trivalent metal ions. Various metal (e.g., transition, main group, and lanthanide) complexes of the hydroxy-substituted texaphyrin derivatives of the present invention have unusual water solubility and stability. They absorb light strongly in a physiologically important region (i.e. 690-880 nm). They have enhanced relaxivity and therefore are useful in magnetic resonance imaging. They form long-lived triplet states in high yield and act as photosensitizers for the generation of singlet oxygen. Thus, they are useful for inactivation or destruction of enveloped viruses, mononuclear or other cells infected with such viruses as well as tumor cells. They are water soluble, yet they retain sufficient lipophilicity so as to have greater affinity for lipid rich areas such as atheroma and tumors. They may be used for magnetic resonance imaging followed by photodynamic tumor therapy in the treatment of atheroma and tumors. These properties, coupled with their high chemical stability and appreciable solubility in water, add to their usefulness.
STATES
5570018 The disclosed system employs an MRI device to identify the location of an area of interest within a patient’s breast and guide a medical instrument for insertion to the identified location. The patient is positioned on a table top having an opening through which the patient’s breast pendulantly projects. The pendulant breast is immobilized by a basket. The table top and patient are then introduced into magnetic field generator and MRl signals are received by receiver. The location of an area of interest within the patient’s breast is determined based on the received signals. A guidance assembly can then be used to aim the medical instrument towards the location of interest via a penetration path selected so as to avoid the receiver and basket.
5569759 WATER SOLUBLE TEXAPHYRIN METAL COMPLEX PREPARATION Sessler Jonathan L; Hemmi Gregory W; Mody Tarak D Austin, TX, UNITED STATES assigned to Board of Regents University of Texas System The
present
invention
involves
water
soluble
METHOD OF AND APPARATUS FOR OBTAINING SPATIAL NMR INFORMATION Halse Roger Beltinge, UNITED KINGDOM British Technology Group Limited
assigned to
PCT No. PCT/GB93/00052 Sec. 371 Date Jun. 2, 1994 Sec. 102(e) Date Jun. 2, 1994 PCT Filed Jan. 12, 1993 PCT Pub. No. WO93/14416 PCT Pub. Date Jul. 22, 1993. Spatial NMR information is obtained from a sample by applying a magnetic field having a static component and two sinusoidally time varying gradient components (Gy, Gz), the period of one gradient component (Gz) being preferably twice the period of the other gradient component (Gy). An RF excitation pulse is applied at the instant both gradient field components are zero. A plurality of NMR sampling responses are produced by gradient echoes in data capture windows and the amplitudes of the gradient field components are varied to provide a desired distribution of sampling path in k-space in each data capture window the gradient field components are reversed in direction to enable all quadrants of k-space to be sampled.