- Email: [email protected]
5284755 DNA encoding leukemia inhibitory factor receptors
PATENT ABSTRACTS Coccidioides immitis from Auxarthron thaxteri, Blastomyces dermatitidis, Geotrichum candidum, Gymnoascus dugwayensis, Histoplasma capsulatum, and Malbranchea albolutea using said probe is also disclosed.
5284755 DNA ENCODING LEUKEMIA INHIBITORY FACTOR RECEPTORS David Gearing, M Patricia Beckmann assigned to lmmunex Corporation Leukemia inhibitory factor receptor (LIF-R) proteins, DNAs and expression vectors encoding LIF-R, and processes for producing LIF-R as products of recombinant cell culture, are disclosed.
569
without specific sequence requirements using the polymerase chain reaction (PCR). The method entails the use of primers which are complementary to the 3' and 5' ends of the desired sequence to be inserted as well as to the 3' and 5' ends of the chosen site of insertion in the acceptor molecule. The desired sequence is amplified by PCR such that single stranded fragments are produced. The single stranded fragment of the desired sequence is then annealed to a single stranded acceptor molecule at the site of insertion and extended to produce a double stranded molecule. The double stranded molecule is then separated into two strands which are identical except that one of the strands contains the desired sequence inserted at the chosen site. A second double stranded molecule is then generated.
5284763 NUCLEIC ACID ENCODING BETA AND ITS USES
5284756 HETERODIMERIC OSTEOGENIC FACTOR
Lynn Grinna, Georgia Theofan, Thomas F Parsons The present invention provides osteogenically active protein preparations comprising a heterodimer of P3 OF 31-34 subunit B and P3 OF 31-34 suhunit D, which subunits are linked with at least one disulfide bond and methods for their preparation. The invention further provides cell lines transformed with nucleotide sequences encoding P3 OF 31-34 subunit B and P3 OF 3134 subunit D and vectors comprising those sequences in operative association with an expression control sequence.
5284760 TECHNIQUES FOR PRODUCING SITE-DIRECTED MUTAGENESIS OF CLONED DNA Stephen Feinstone, Czeslaw Wychowski, Jonathan E Silver, Suzanne U Emerson A method is described whereby new cDNA or RNA sequences can be introdtmed into or substituted for cDNA in any chosen position
TGF-
R i k M A D e r y n k , David V Goeddel assigned to Genentech Inc Nucleic acid encoding TGF- beta has been isolated and cloned into vectors which are replicated in bacteria and expressed in eukaryotic cells. TGF- beta is recovered from transformed cultures for use in known therapeutic modalities. Nucleic acid encoding TGF- beta is useful in diagnosis and identification of TGF- beta clones.
5284764 CHIMERIC GLYCOPROTEINS CONTAINING IMMUNOGENIC SEGMENTS OF HUMAN PARAINFLUENZA VIRUS TYPE 3 Michael W Wathen assigned to The Upjohn Company This invention encompasses novel chimeric glycoproteins which are useful for preparing virus specific immune responses against human parainfluenza virus type 3, PIV3. Host cells transformed with structural genes coding for the glycoproteins, expression and replication plasmids containing the structural genes, vaccines made from the glycoproteins and methods for protecting humans by inoculation with said vaccines are also part of this invention.
5284755 DNA ENCODING LEUKEMIA INHIBITORY FACTOR RECEPTORS David Gearing, M Patricia Beckmann assigned to lmmunex Corporation Leukemia inhibitory factor receptor (LIF-R) proteins, DNAs and expression vectors encoding LIF-R, and processes for producing LIF-R as products of recombinant cell culture, are disclosed.
569
without specific sequence requirements using the polymerase chain reaction (PCR). The method entails the use of primers which are complementary to the 3' and 5' ends of the desired sequence to be inserted as well as to the 3' and 5' ends of the chosen site of insertion in the acceptor molecule. The desired sequence is amplified by PCR such that single stranded fragments are produced. The single stranded fragment of the desired sequence is then annealed to a single stranded acceptor molecule at the site of insertion and extended to produce a double stranded molecule. The double stranded molecule is then separated into two strands which are identical except that one of the strands contains the desired sequence inserted at the chosen site. A second double stranded molecule is then generated.
5284763 NUCLEIC ACID ENCODING BETA AND ITS USES
5284756 HETERODIMERIC OSTEOGENIC FACTOR
Lynn Grinna, Georgia Theofan, Thomas F Parsons The present invention provides osteogenically active protein preparations comprising a heterodimer of P3 OF 31-34 subunit B and P3 OF 31-34 suhunit D, which subunits are linked with at least one disulfide bond and methods for their preparation. The invention further provides cell lines transformed with nucleotide sequences encoding P3 OF 31-34 subunit B and P3 OF 3134 subunit D and vectors comprising those sequences in operative association with an expression control sequence.
5284760 TECHNIQUES FOR PRODUCING SITE-DIRECTED MUTAGENESIS OF CLONED DNA Stephen Feinstone, Czeslaw Wychowski, Jonathan E Silver, Suzanne U Emerson A method is described whereby new cDNA or RNA sequences can be introdtmed into or substituted for cDNA in any chosen position
TGF-
R i k M A D e r y n k , David V Goeddel assigned to Genentech Inc Nucleic acid encoding TGF- beta has been isolated and cloned into vectors which are replicated in bacteria and expressed in eukaryotic cells. TGF- beta is recovered from transformed cultures for use in known therapeutic modalities. Nucleic acid encoding TGF- beta is useful in diagnosis and identification of TGF- beta clones.
5284764 CHIMERIC GLYCOPROTEINS CONTAINING IMMUNOGENIC SEGMENTS OF HUMAN PARAINFLUENZA VIRUS TYPE 3 Michael W Wathen assigned to The Upjohn Company This invention encompasses novel chimeric glycoproteins which are useful for preparing virus specific immune responses against human parainfluenza virus type 3, PIV3. Host cells transformed with structural genes coding for the glycoproteins, expression and replication plasmids containing the structural genes, vaccines made from the glycoproteins and methods for protecting humans by inoculation with said vaccines are also part of this invention.