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5472841 Methods for identifying nucleic acid ligands of human neutrophil elastase
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PATENT ABSTRACTS
Methods and compositions are described for making ribozymes which can release or activate molecules including autocatalytically replicatable RNA such as MDV-1. 5472841
METHODS FOR IDENTIFYING NUCLEIC ACID LIGANDS OF HUMAN NEUTROPHIL ELASTASE Jayasena Sumedha D; Gold Larry Boulder, CO, UNITED STATES assigned to NeXstar Pharmaceuticals Inc Methods are described for the identification and preparation of nucleic acid ligands to human neutrophil elastase. Included in the invention are specific RNA and DNA ligands to elastase identified by the SELEX method.
5472844 METHODS OF DETECTION OF TOXOPLASMA GONDII P22 GENE De Araujo Faust0 G; Prince Jeffrey; Remington Jack Palo Alto, CA, UNITED STATES assigned to Research Institute of Palo Alto Medical Foundation Genetic material encoding the P22 peptide of Toxoplasma gondii has been isolated and characterized. This genetic material allows the production of peptides for use in diagnosis or immunization or can itself be directly used in hybridization assays.
5472850 QUANTITATIVE CLOTTING ASSAY FOR ACTIVATED FACTOR VII
5472843 NUCLEIC ACID PROBES TO HAEMOPHILUS INFLUENZAE Milliman Curt L St Louis, MO, UNITED Gen-Probe STATES assigned to Incorporated This invention discloses hybridization assay Haemophilus influenzae probes for comprised of an oligonucleotide of about 14 to 18 nucleotides. These probes hybridize to variable regions of the 16s rRNA gene of The influenzae. Haemophilus oligonucleotide probes are complementary to the rR_NA variable region of the rRNA gene. Such probe specificity offers a rapid, non-subjective method of identification and quantitation of a bacterial colony for the presence of selected rRNA sequences capable of distinguishing all strains of Haemophilus influenzae.
Morrissey James H Oklahoma City, OK, UNITED STATES assigned to Oklahoma Medical Research Foundation An assay for activated factor VII (factor VIIa) has been developed using truncated tissue factor (tTF), a soluble mutant form of (tTF) that retains the cofactor function of TF toward factor VIIa. Unlike full-length TF, however, tTF appears not to support the conversion of factor VII to VIIa. As a result, the tTF assay for factor VIIa is free from interference from factor VII in the plasma and is therefore specific for factor VIIa. The assay is much simpler than existing assays,because it is a single-stage clotting assay performed almost identically to a prothrombin time assay. It is also considerably more sensitive than current assays for factor VIIa in plasma. Since the tTF assay is calibrated against a factor VIIa standard, it yields an absolute concentration of factor VIIa in ng/ml.
PATENT ABSTRACTS
Methods and compositions are described for making ribozymes which can release or activate molecules including autocatalytically replicatable RNA such as MDV-1. 5472841
METHODS FOR IDENTIFYING NUCLEIC ACID LIGANDS OF HUMAN NEUTROPHIL ELASTASE Jayasena Sumedha D; Gold Larry Boulder, CO, UNITED STATES assigned to NeXstar Pharmaceuticals Inc Methods are described for the identification and preparation of nucleic acid ligands to human neutrophil elastase. Included in the invention are specific RNA and DNA ligands to elastase identified by the SELEX method.
5472844 METHODS OF DETECTION OF TOXOPLASMA GONDII P22 GENE De Araujo Faust0 G; Prince Jeffrey; Remington Jack Palo Alto, CA, UNITED STATES assigned to Research Institute of Palo Alto Medical Foundation Genetic material encoding the P22 peptide of Toxoplasma gondii has been isolated and characterized. This genetic material allows the production of peptides for use in diagnosis or immunization or can itself be directly used in hybridization assays.
5472850 QUANTITATIVE CLOTTING ASSAY FOR ACTIVATED FACTOR VII
5472843 NUCLEIC ACID PROBES TO HAEMOPHILUS INFLUENZAE Milliman Curt L St Louis, MO, UNITED Gen-Probe STATES assigned to Incorporated This invention discloses hybridization assay Haemophilus influenzae probes for comprised of an oligonucleotide of about 14 to 18 nucleotides. These probes hybridize to variable regions of the 16s rRNA gene of The influenzae. Haemophilus oligonucleotide probes are complementary to the rR_NA variable region of the rRNA gene. Such probe specificity offers a rapid, non-subjective method of identification and quantitation of a bacterial colony for the presence of selected rRNA sequences capable of distinguishing all strains of Haemophilus influenzae.
Morrissey James H Oklahoma City, OK, UNITED STATES assigned to Oklahoma Medical Research Foundation An assay for activated factor VII (factor VIIa) has been developed using truncated tissue factor (tTF), a soluble mutant form of (tTF) that retains the cofactor function of TF toward factor VIIa. Unlike full-length TF, however, tTF appears not to support the conversion of factor VII to VIIa. As a result, the tTF assay for factor VIIa is free from interference from factor VII in the plasma and is therefore specific for factor VIIa. The assay is much simpler than existing assays,because it is a single-stage clotting assay performed almost identically to a prothrombin time assay. It is also considerably more sensitive than current assays for factor VIIa in plasma. Since the tTF assay is calibrated against a factor VIIa standard, it yields an absolute concentration of factor VIIa in ng/ml.