Nucleic acid ligands of tissue target

• les derniers brevets deposes: morceaux choisis • realisee en collaboration avec I'inpi

AGRICULTURE AGROINDUSTRIE Productions animales > Gene marker associated with swine proliferacy (BA Didion and MA Johns, US). Dekalb Swine Breeders Inc and Northern Illinois University W WO 96/33288. PCT A random amplification method for determining swine genetic markers associated with small and large Jitter sizes is provided. One such marker is an approximatively 270 base-pair amplification product... This marker can be used to inform breeding programs designed to increase the litter size of certain swine breeds.

Productions veglHales > Transgenic plants with

altered senescence characteristics (RM Amasino and S Gan, US). Wisconsin Alumni Resarch Foundation and the inventors N°WO 96/29858. PCT

> Use of Streptomyces bacteria to control plant pathogens and degrade turf thatch (DL Crawford, US). Idaho Research Foundation and the inventor W WO 96/29874, PCT This invention relates to biocontrol formulations suitable for reducing the susceptibility of plants to fungal phytopathogens and for degrading turf thatch...

>

Genetic sequences conferring nematode resistance in plants and uses therefor (ES Lagudah, AU). Commonwealth Scientific and Industrial Research Organisation and the inventor N" WO 96/30517, PCT The present invention relates generally to a nucleic acid molecule encoding, or complementary to a nucleic acid molecule encoding, a polypeptide which confers, enhances, or otherwise facili-

tares resistance to J nematode in a plant cell...

> Regeneration of both plant tissues and transgenic plant tissues using a new plant hormone-5-bromoindole-3-acetic acid (JJ Lin et ai, US). Life Technologies Inc W WO 96/34089. PCT The present invention describes the use of 5-hrornoindole-Laccric acid 15B-lAA) as an auxin afb:ting plant cell growth ...

> Method for production of plant biological products in precocious neomorphic embryoids (SR Wann, US). Union Camp Corp W WO 96/34522. PCT The present invention relates to making precocious ncomorphic embryoids (PNE) and their use for producing biological products. Specifically, the invention provides a method for increasing taxol production from embryogenic Taxus cultures...

Alimentation > Procede d'lnteresterification de phospholipides (0 Chmiel et ai, CH). Societe des produits Nestle SA W 739985, EP. Un precede dintersesterification d'un phospholipide avec un triacylglycerol consiste it utiliser un systeme enzymarique constitue d'une lipase immobilisee et d'une phospholipase imrnobilisee, Les phospholipides obtenus peuvent etre utilises dans des systernes ernulsionnes ou dans des enrobages pour poudres instantaneisees,

> High trehalose content

syrup (K Okada et ai, JP). Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo W 739986, EP.

> Barley

~-amylase structural gene (N Yoshigi and Y Okada, JP). Sapporo Breweries Ltd W WO 96/30525, PCT.

> Bread-improving addi-

tive comprising a xylano-

lytic enzyme (OB Jorgensen et ai, OK). Novo Nordisk AlS and the inventors N" WO 96/32472. PCT The prcscnr invcnrion relates to brcad-uuprovi nu additives ...

> Ensemencement par Geotrichum candidum au cours du maltage de cereales ou autres vegetaux (P Boivin et M'B Malanda, FR). Instirur fLlI1<;ais des boissons. de la br.isseri« maltcric et Irs in H'ntCLI rs W WO 96/34085. ret

SANTE Pr u t ein es et p e pt i d es > New chemokine expressed in eosinophils (0 Bandman et ai, US). lncyte Pharmaceuticals Inc W WO 96/32481. PCl

> Genetic sequences and proteins related to Alzheimer's disease, and uses therefor (PH George-Hyslop et ai, CAl. HSC Research and Development Ltd Partnership, the Governing Council of the University of Toronto and the inventors W WO 96/34099, PCl The present invention describes the identification, isolation, sequencing and characterization of two human presenilin genes, PS-l and PS-2, mutations which lead to familial Alzheimer's disease ... Nucleic acids and proteins comprising or derived from the presenilins are useful in screening and diagnosing Alzheimer's disease ...

Macromolecuies > Nucleic acid ligands of tissue target (A Sthephens at ai, US). Nexstar Pharmaceuticals Inc and Schering AG W WO 96/34874, PCl This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tis-

sue targets, and the methods for obtaining such ligands...

Antibiotiques > Procede d'identification bacterienne et de determination de la sensibilite de bacteries it des antibiotiques et appareil de supports de mesure pour la mise en ceuvre de ce precede (J Bajard, FR). Pasteur Sanofi Diagnositcs W 742284 EP > Glycopeptide antibiotic derivatives (RD Cooper et ai, US). Eli Lilly and Co and the inventors W WO 96/30401, PCl The present invention provides glycopeptide antibiotic derivative compounds. These derivatives compounds possess antibacterial activity against a wide varierv of bacteria, including activirv against vancomycinresistant isolates ....

Diagnostic > Isolated 55 to 75 kDa protein which binds to prion protein (RR Brentani et ai, BR). Ludwig Institute for Cancer Resarch and the inventors W WO 96/32128, PCl The invention involves isolated anti prion-protein binding proteins which have molecular weights of from about 55 kD to about 72 kD as determined by SDSPAGE. Also described is a peptide derived from an isolated anti-prion protein binding protein. Diagnostic uses for each of these molecules are discussed. > Genetic markers for breast and ovarian cancer (MC King et ai, US). The Regents of the University of California W WO 96/33271, PCT. Specific BRCAI mutations, PCR primers and hybridization probes are used in nucleic acid-based methods for diagnostic of inheritable breast cancer susceptibility... > Repertoire cloning process, products derived therefrom and uses for BIOFUTUR 163 • Janvier 1997 43

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