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551 HUMAN PAPILLOMAVIRUS PREVALENCE AND CORRELATION TO HISTOPATHOLOGICAL STATUS IN PENILE CARCINOMA
Material & Methods: $IWHUVXUJHU\WXPRXUVSHFLPHQRIWKHSULPDU\WXPRXUVDQG O\PSKQRGHPHWDVWDVHVZHUHFXOWXUHGLQYLWURDQG[HQRWUDQVSODQWHGLQ6&,'EHLJH PLFH $OO VSHFLPHQV ZHUH + ( VWDLQHG DQG LPPXQRVWDLQHG IRU F\WRNHUDWLQ F\WRNHUDWLQDQGS Results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onclusions: :H HVWDEOLVKHG WKH ᚏUVW GHᚏQLWLYH KXPDQ SULPDU\ DQG PHWDVWDWLF FDUFLQRPD FHOO OLQHV RI SHQLOH FDUFLQRPD 7KHVH FHOO OLQHV RᚎHU SRVVLELOLWLHV WR SHUIRUP IXUWKHU IXQFWLRQDO LQYHVWLJDWLRQV XQGHU LQYLWUR DQG LQYLYR VHWWLQJV 7KH\ DOORZ VWXGLHV RI QHZ SRWHQWLDO WKHUDSHXWLF DJHQWV DQG RWKHU DVVD\V IRU D EHWWHU XQGHUVWDQGLQJRIWKHPROHFXODUPHFKDQLVPLQSHQLOHFDQFHU
550
IDENTIFICATION OF SERUM PROTEIN PATTERNS IN PATIENTS WITH PENILE CARCINOMA
'LHNHU:5RPLFV,6]HQGURL$3LOFKRZVNL5:DOWHU0:XQGHUOLFK+ -XQNHU. 1 University Hospitals Jena, Dept. of Urology, Jena, Germany, 2Semmelweis University, Dept. of Urology, Budapest, Hungary Introduction & Objectives: 3HQLOHFDUFLQRPDLVYHU\UDUHLQ(XURSHDQGDFFRXQWV IRURIDOOPDOLJQDQWGLVHDVHV+RZHYHULQVRPHSDUWVRIWKHGHYHORSLQJ FRXQWULHVLWKDVDKLJKHUIUHTXHQF\XSWR$WWKHPRPHQWQRELRPDUNHUVDUH DYDLODEOHIRUGLDJQRVWLFVSURJQRVWLFHYDOXDWLRQWUHDWPHQWPRQLWRULQJDQGIROORZ XS7KHUHIRUHRXUSXUSRVHZDVWRLGHQWLI\VSHFLᚏFVHUXPSURWHLQSDWWHUQVIRUSHQLOH FDQFHU Material & Methods: 6HUXPSURWHLQSURᚏOHVRISDWLHQWVZLWKSHQLOHFDQFHUDQG KHDOWK\PHQ FRQWUROJURXS ZHUHDQDO\VHGE\6XUIDFHHQKDQFHGODVHUGHVRUSWLRQ LRQL]DWLRQWLPHRIᚐLJKWPDVVVSHFWURPHWU\ 6(/',72)06 $IWHUGHSOHWLRQRIWKH KLJK DEXQGDQFH SURWHLQ DOEXPLQ XVLQJ 3URWHRPH/DE +6$ 6SLQ &ROXPQ GLOXWHG VDPSOHVZHUHDSSOLHGWRWKUHHW\SHVRI3URWHLQ&KLS$UUD\V ,0$&&0DQG 43URWHLQVERXQGHGWRWKHFKHPLFDOVXUIDFHRIWKH3URWHLQ&KLSZHUHGHWHFWHG E\6(/',72)06DQGWKHSURWHLQH[SUHVVLRQVZHUHDQDO\]HGXVLQJWKH;/0LQHU VRIWZDUH Results: )RXU FRQGLWLRQDO UXOHV ZKLFK DOORZ GLVFULPLQDWLRQ EHWZHHQ FDQFHU DQG FRQWURO JURXS ZHUH JHQHUDWHG IRU HDFK 3URWHLQ&KLS ,0$& &0 4 XVLQJ ELRLQIRUPDWLFV 6HSDUDWH DQDO\VLVRI SULPDU\ GDWD VKRZHG VHQVLWLYLWLHV DQG VSHFLᚏFLWLHVRIDQG ,0$& DQG &0 DQG 4 UHVSHFWLYHO\ +LJKHVW DFFXUDF\ ZDV DFKLHYHG E\ FRPELQDWLRQ RI DOO WKUHH FKLS W\SHV VHQVLWLYLW\DQGVSHFLᚏFLW\7KHSUHGLFWLRQPRGHOZDVYDOLGDWHG ZLWKDQRWKHUVHWRIVDPSOHVZLWKSHQLOHFDUFLQRPDDQGFRQWUROVDPSOHVDQG DFKLHYHGVHQVLWLYLW\DQGVSHFLᚏFLW\ Conclusions: 8VLQJ 6(/',72)06 DQG ELRLQIRUPDWLFV ZH ZHUH DEOH WR GHᚏQH VSHFLᚏFVHUXPSURWHLQSDWWHUQVLQSDWLHQWVZLWKSHQLOHFDQFHUZLWKKLJKDFFXUDF\ 5HVXOWV ZHUH KLJKO\ UHSURGXFLEOH LQ DQ LQGHSHQGHQW WHVW VHW ,GHQWLᚏFDWLRQ RI UHOHYDQWSURWHLQVZLOOEHRXUQH[WVWHS
551
HUMAN PAPILLOMAVIRUS PREVALENCE AND CORRELATION TO HISTOPATHOLOGICAL STATUS IN PENILE CARCINOMA
.LUUDQGHU3.RODULF$+HOHQLXV*:LQGDKO7$QGU«Q2(OJK) .DUOVVRQ0* 1 Örebro University Hospital, Dept. of Urology, Örebro, Sweden, 2Örebro University Hospital, Dept. of Laboratory Medicine/Pathology, Örebro, Sweden, 3Umeå University, Dept. of Clinical Microbiology/Virology, Umeå, Sweden Introduction & Objectives: 3HQLOH FDUFLQRPD LV D UDUH PDOLJQDQF\ LQ WKH ZHVWHUQZRUOG,Q6ZHGHQWKHDQQXDOLQFLGHQFHLVSHUPHQ3HQLOH FDUFLQRPDKDVPDQ\VLPLODULWLHVZLWKFHUYLFDOFDUFLQRPDZKHUHQHDUO\DOOWXPRXUV DUHKXPDQSDSLOORPDYLUXV +39 SRVLWLYH7KHSUHGRPLQDQW+39W\SHVLQFHUYLFDO FDUFLQRPD DURXQG DUH +39 DQG DQG SURSK\ODFWLF YDFFLQHV KDYH UHFHQWO\EHHQLQWURGXFHG,QUHSRUWHGSDWLHQWPDWHULDOVWKHSUHYDOHQFHRI+39LQ SHQLOHFDUFLQRPDYDULHVEHWZHHQDQG7KHODUJHYDULDWLRQLQSRVLWLYH ᚏQGLQJV PLJKW GHSHQG RQ PHWKRGRORJLFDO GLᚎHUHQFHV GLᚎHUHQFHV DPRQJ WKH LQYHVWLJDWHGSRSXODWLRQVDQGVPDOOVWXG\JURXSV,QWKHSUHVHQWVWXG\WKHDLPZDV WRLQYHVWLJDWHWKHSUHYDOHQFHRI+39LQDODUJH6ZHGLVKFRKRUWDQGFRUUHODWHWKH GDWDWRKLVWRSDWKRORJLFDOSDUDPHWHUVLQRUGHUWRGHWHUPLQHWKHSURJQRVWLFYDOXHRI +39VWDWXV Material & Methods: SDWLHQWVZLWKSHQLOHVTXDPRXVFHOOFDUFLQRPDWUHDWHGDW WKH8QLYHUVLW\+RVSLWDOLQUHEUR6ZHGHQEHWZHHQ DQGZHUHLQFOXGHG 7KHPHDQDJHDWGLDJQRVLVZDV$OOWXPRXUVZHUHFODVVLᚏHGDFFRUGLQJWRWKH FXUUHQW 710 FODVVLᚏFDWLRQ SDWLHQWV ZHUH RSHUDWLYHO\ VWDJHG ZLWK UHJDUG WR O\PSK QRGH PHWDVWDVLV $OO WLVVXH VDPSOHV ZHUH IRUPDOLQ ᚏ[HG DQG SDUDᚑQ HPEHGGHG 7KUHH PP FRUHV RI WXPRXU WLVVXH ZKHUH SXQFKHG RXW RI WKH SDUDᚑQEORFN'1$ZDVH[WUDFWHGVXEVHTXHQWO\TXDOLW\DQGTXDQWLW\RI'1$ZDV
Eur Urol Suppl 2010;9(2):188
GHWHUPLQHG5HDO7LPH3&5ZDVXVHGWRGHWHFWGLᚎHUHQWW\SHVRI+39 DQG $OOVDPSOHVZHUHDQDO\]HGLQGXSOLFDWHDQG SRVLWLYHFRQWUROVZHUHXVHG Results: RXWRISDWLHQWVZHUHH[FOXGHGGXHWRORZTXDOLW\RIWKHH[WUDFWHG '1$+39ZDVGHWHFWHGLQRIWKHUHPDLQLQJ WXPRXUVDPSOHV$ VLQJOH+39LQIHFWLRQZDVVHHQLQDGRXEOHLQDQGPXOWLSOH+39LQIHFWLRQV !W\SHV LQRIWKH+39SRVLWLYHWXPRXUVDPSOHV7KHPRVWFRPPRQ+39 W\SHZDV+39SUHVHQWLQRIDOOWXPRXUVDPSOHVIROORZHGE\VLPXOWDQHRXV +39DQG DQG+39DORQH ,QWRWDORIWKHSDWLHQWVZHUH LQIHFWHGE\HLWKHURUERWK+39DQG+391RFRUUHODWLRQEHWZHHQ+39VWDWXV QHJYVSRV +39YVQRQ WRWXPRXUH[WHQW S7LVS7 JUDGH * * QRUQRGDOVWDWXV S1RUS1 ZDVREVHUYHG Conclusions: 7KHSUHVHQWVWXG\RI+39SUHYDOHQFHLQSHQLOHFDUFLQRPDLVRQHRI WKHODUJHVW7KHSUHYDOHQFHIRXQG LVKLJKHUWKDQUHSRUWHGLQPRVWRWKHU VWXGLHV$FFRUGLQJWRRXUGDWD+39DQGRUSUHYDOHQFHLQSHQLOHFDUFLQRPDLV FRPSDUDEOHWRZKDWLVVHHQLQFHUYLFDOFDUFLQRPDUDLVLQJWKHTXHVWLRQRIZKDWHᚎHFW +39YDFFLQHFRXOGKDYHRQSHQLOHFDUFLQRPDLQFLGHQFH7KHUHZDVQRVLJQLᚏFDQW FRUUHODWLRQ EHWZHHQ +39 VWDWXV DQG KLVWRSDWKRORJLFDO SDUDPHWHUV VXEVHTXHQWO\ +39KDVQRSURJQRVWLFYDOXHDFFRUGLQJWRRXUGDWD
552
SIGNIFICANCE OF POSITIVE SURGICAL MARGINS IN ORGAN-SPARING SURGERY FOR INVASIVE SQUAMOUS CARCINOMA OF THE PENIS
/DP:0DJULOO'$\UHV%(3HUU\0-$&RUELVKOH\&0:DWNLQ1 1 St George’s Hospital, Dept. of Urology, London, United Kingdom, 2St George’s Hospital, Dept. of Histopathology, London, United Kingdom Introduction & Objectives: 2UJDQVSDULQJ VXUJHU\ LQ WKH WUHDWPHQW RI SHQLOH FDQFHU 6&& UHTXLUHV D FRPSURPLVH EHWZHHQ SUHVHUYDWLRQ RI IXQFWLRQ DQG DFFHSWDEOHFRVPHWLFDSSHDUDQFHZLWKWKHQHHGIRUORFDOFDQFHUFRQWURO7KLVVWXG\ DLPV WR GHWHUPLQH WKH VLJQLᚏFDQFH RI D SRVLWLYH LQYDVLYH VXUJLFDO PDUJLQ DIWHU SHQLOHSUHVHUYLQJ VXUJHU\ DQG WR LGHQWLI\ DSSURSULDWH PDQDJHPHQW VWUDWHJLHV LQ VXFKSDWLHQWV Material & Methods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esults: RXW RI SHQLOH SUHVHUYLQJ SURFHGXUHV ZHUH LGHQWLᚏHG WR KDYH DQ LQYDVLYH SRVLWLYH PDUJLQ )ROORZ XS PRQWKV SDWLHQWV KDG HDUO\ UH UHVHFWLRQ RI ZKRP KDG UHVLGXDO GLVHDVH DQG KDG QR GLVHDVH SDWLHQWV UHTXLUHG IXUWKHU UHVHFWLRQV EHWZHHQ UHUHVHFWLRQV EHIRUH EHLQJ UHQGHUHGGLVHDVHIUHH)RUSDWLHQWVRQVXUYHLOODQFHKDGFRQᚏUPHGUHFXUUHQFH DQG UHPDLQUHFXUUHQFHIUHH Conclusions: )RFDOSRVLWLYHPDUJLQVKDYHDORZUDWHRIUHFXUUHQFHLQRXUVHULHV DQG FRXOG EH REVHUYHG LQLWLDOO\ LI WKHUH LV QR YLVLEOH DEQRUPDOLW\ 7KH UHFXUUHQFH UDWHIRUPRUHH[WHQVLYHPDUJLQVMXVWLᚏHVHDUO\UHUHVHFWLRQ
553
DETECTION OF INGUINAL LYMPH NODE INVOLVEMENT IN PENILE SQUAMOUS CELL CARCINOMA BY 18F-FLUORODEOXYGLUCOSE PET/CT
6FKOHQNHU%*UDW]NH&5HLFK27LONL'6FKQHHGH37LOLQJ5 %DUWHQVWHLQ36LHJHUW66WLHI&*6HLW]0 1 University Hospital Grosshadern Ludwig-Maximilians-University Munich, Dept. of Urology, Munich, Germany, 2Hospital Memmingen, Dept. of Urology, Memmingen, Germany, 3University Hospital Grosshadern Ludwig-Maximilians-University Munich, Dept. of Nuclear Medicine, Munich, Germany, 4University Hospital Grosshadern Ludwig-Maximilians-University Munich, Dept. of Pathology, Munich, Germany Introduction & Objectives: 7RSURVSHFWLYHO\DQDO\]HWKHGLDJQRVWLFDFFXUDF\RI ))'*3(7&7VFDQLQWKHDVVHVVPHQWRILQJXLQDOO\PSKQRGHLQYROYHPHQWLQ SDWLHQWVZLWKLQYDVLYHSHQLOHFDUFLQRPDDVWKHH[WHQWRIO\PSKQRGHLQYROYHPHQWLV WKHPRVWUHOHYDQWSURJQRVWLFIDFWRULQSDWLHQWVZLWKSHQLOHFDQFHU Material & Methods: SDWLHQWV ZLWK LQYDVLYH SHQLOH FDUFLQRPD ZHUH VWDJHG SURVSHFWLYHO\E\))'*3(7&7VFDQ))'*3(7&7VFDQZDVSHUIRUPHG DQG EOLQGO\ HYDOXDWHG E\ WZR QXFOHDU PHGLFLQH SK\VLFLDQV ,Q WRWDO O\PSK QRGH LQYROYHPHQWZDVDVVHVVHGLQLQJXLQDOJURLQV5HIHUHQFHVWDQGDUGZDVHLWKHU KLVWRORJ\RUFOLQLFDOIROORZXSZLWKDPLQLPXPRIPRQWKV PHDQ PRQWKV UDQJH ದPRQWKV Results: )'*3(7&7 VKRZHG D VHQVLWLYLW\ RI DQG D VSHFLᚏFLW\ RI 3RVLWLYHSUHGLFWLYHYDOXH 339 ZDV ZKLOHQHJDWLYHSUHGLFWLYHYDOXH 139 ZDV ,QWZRJURLQVPHWDVWDVLVRIPPDQGPPZHUHPLVVHGE\ 3(7&7VFDQ Conclusions: ))'*3(7&7 LV D SURPLVLQJ VWDJLQJ WRRO LQ DVVHVVLQJ WKH LQJXLQDOO\PSKQRGHLQYROYHPHQWRISDWLHQWVZLWKSHQLOHFDUFLQRPD,QWHJUDWLRQRI
550
IDENTIFICATION OF SERUM PROTEIN PATTERNS IN PATIENTS WITH PENILE CARCINOMA
'LHNHU:5RPLFV,6]HQGURL$3LOFKRZVNL5:DOWHU0:XQGHUOLFK+ -XQNHU. 1 University Hospitals Jena, Dept. of Urology, Jena, Germany, 2Semmelweis University, Dept. of Urology, Budapest, Hungary Introduction & Objectives: 3HQLOHFDUFLQRPDLVYHU\UDUHLQ(XURSHDQGDFFRXQWV IRURIDOOPDOLJQDQWGLVHDVHV+RZHYHULQVRPHSDUWVRIWKHGHYHORSLQJ FRXQWULHVLWKDVDKLJKHUIUHTXHQF\XSWR$WWKHPRPHQWQRELRPDUNHUVDUH DYDLODEOHIRUGLDJQRVWLFVSURJQRVWLFHYDOXDWLRQWUHDWPHQWPRQLWRULQJDQGIROORZ XS7KHUHIRUHRXUSXUSRVHZDVWRLGHQWLI\VSHFLᚏFVHUXPSURWHLQSDWWHUQVIRUSHQLOH FDQFHU Material & Methods: 6HUXPSURWHLQSURᚏOHVRISDWLHQWVZLWKSHQLOHFDQFHUDQG KHDOWK\PHQ FRQWUROJURXS ZHUHDQDO\VHGE\6XUIDFHHQKDQFHGODVHUGHVRUSWLRQ LRQL]DWLRQWLPHRIᚐLJKWPDVVVSHFWURPHWU\ 6(/',72)06 $IWHUGHSOHWLRQRIWKH KLJK DEXQGDQFH SURWHLQ DOEXPLQ XVLQJ 3URWHRPH/DE +6$ 6SLQ &ROXPQ GLOXWHG VDPSOHVZHUHDSSOLHGWRWKUHHW\SHVRI3URWHLQ&KLS$UUD\V ,0$&&0DQG 43URWHLQVERXQGHGWRWKHFKHPLFDOVXUIDFHRIWKH3URWHLQ&KLSZHUHGHWHFWHG E\6(/',72)06DQGWKHSURWHLQH[SUHVVLRQVZHUHDQDO\]HGXVLQJWKH;/0LQHU VRIWZDUH Results: )RXU FRQGLWLRQDO UXOHV ZKLFK DOORZ GLVFULPLQDWLRQ EHWZHHQ FDQFHU DQG FRQWURO JURXS ZHUH JHQHUDWHG IRU HDFK 3URWHLQ&KLS ,0$& &0 4 XVLQJ ELRLQIRUPDWLFV 6HSDUDWH DQDO\VLVRI SULPDU\ GDWD VKRZHG VHQVLWLYLWLHV DQG VSHFLᚏFLWLHVRIDQG ,0$& DQG &0 DQG 4 UHVSHFWLYHO\ +LJKHVW DFFXUDF\ ZDV DFKLHYHG E\ FRPELQDWLRQ RI DOO WKUHH FKLS W\SHV VHQVLWLYLW\DQGVSHFLᚏFLW\7KHSUHGLFWLRQPRGHOZDVYDOLGDWHG ZLWKDQRWKHUVHWRIVDPSOHVZLWKSHQLOHFDUFLQRPDDQGFRQWUROVDPSOHVDQG DFKLHYHGVHQVLWLYLW\DQGVSHFLᚏFLW\ Conclusions: 8VLQJ 6(/',72)06 DQG ELRLQIRUPDWLFV ZH ZHUH DEOH WR GHᚏQH VSHFLᚏFVHUXPSURWHLQSDWWHUQVLQSDWLHQWVZLWKSHQLOHFDQFHUZLWKKLJKDFFXUDF\ 5HVXOWV ZHUH KLJKO\ UHSURGXFLEOH LQ DQ LQGHSHQGHQW WHVW VHW ,GHQWLᚏFDWLRQ RI UHOHYDQWSURWHLQVZLOOEHRXUQH[WVWHS
551
HUMAN PAPILLOMAVIRUS PREVALENCE AND CORRELATION TO HISTOPATHOLOGICAL STATUS IN PENILE CARCINOMA
.LUUDQGHU3.RODULF$+HOHQLXV*:LQGDKO7$QGU«Q2(OJK) .DUOVVRQ0* 1 Örebro University Hospital, Dept. of Urology, Örebro, Sweden, 2Örebro University Hospital, Dept. of Laboratory Medicine/Pathology, Örebro, Sweden, 3Umeå University, Dept. of Clinical Microbiology/Virology, Umeå, Sweden Introduction & Objectives: 3HQLOH FDUFLQRPD LV D UDUH PDOLJQDQF\ LQ WKH ZHVWHUQZRUOG,Q6ZHGHQWKHDQQXDOLQFLGHQFHLVSHUPHQ3HQLOH FDUFLQRPDKDVPDQ\VLPLODULWLHVZLWKFHUYLFDOFDUFLQRPDZKHUHQHDUO\DOOWXPRXUV DUHKXPDQSDSLOORPDYLUXV +39 SRVLWLYH7KHSUHGRPLQDQW+39W\SHVLQFHUYLFDO FDUFLQRPD DURXQG DUH +39 DQG DQG SURSK\ODFWLF YDFFLQHV KDYH UHFHQWO\EHHQLQWURGXFHG,QUHSRUWHGSDWLHQWPDWHULDOVWKHSUHYDOHQFHRI+39LQ SHQLOHFDUFLQRPDYDULHVEHWZHHQDQG7KHODUJHYDULDWLRQLQSRVLWLYH ᚏQGLQJV PLJKW GHSHQG RQ PHWKRGRORJLFDO GLᚎHUHQFHV GLᚎHUHQFHV DPRQJ WKH LQYHVWLJDWHGSRSXODWLRQVDQGVPDOOVWXG\JURXSV,QWKHSUHVHQWVWXG\WKHDLPZDV WRLQYHVWLJDWHWKHSUHYDOHQFHRI+39LQDODUJH6ZHGLVKFRKRUWDQGFRUUHODWHWKH GDWDWRKLVWRSDWKRORJLFDOSDUDPHWHUVLQRUGHUWRGHWHUPLQHWKHSURJQRVWLFYDOXHRI +39VWDWXV Material & Methods: SDWLHQWVZLWKSHQLOHVTXDPRXVFHOOFDUFLQRPDWUHDWHGDW WKH8QLYHUVLW\+RVSLWDOLQUHEUR6ZHGHQEHWZHHQ DQGZHUHLQFOXGHG 7KHPHDQDJHDWGLDJQRVLVZDV$OOWXPRXUVZHUHFODVVLᚏHGDFFRUGLQJWRWKH FXUUHQW 710 FODVVLᚏFDWLRQ SDWLHQWV ZHUH RSHUDWLYHO\ VWDJHG ZLWK UHJDUG WR O\PSK QRGH PHWDVWDVLV $OO WLVVXH VDPSOHV ZHUH IRUPDOLQ ᚏ[HG DQG SDUDᚑQ HPEHGGHG 7KUHH PP FRUHV RI WXPRXU WLVVXH ZKHUH SXQFKHG RXW RI WKH SDUDᚑQEORFN'1$ZDVH[WUDFWHGVXEVHTXHQWO\TXDOLW\DQGTXDQWLW\RI'1$ZDV
Eur Urol Suppl 2010;9(2):188
GHWHUPLQHG5HDO7LPH3&5ZDVXVHGWRGHWHFWGLᚎHUHQWW\SHVRI+39 DQG $OOVDPSOHVZHUHDQDO\]HGLQGXSOLFDWHDQG SRVLWLYHFRQWUROVZHUHXVHG Results: RXWRISDWLHQWVZHUHH[FOXGHGGXHWRORZTXDOLW\RIWKHH[WUDFWHG '1$+39ZDVGHWHFWHGLQRIWKHUHPDLQLQJ WXPRXUVDPSOHV$ VLQJOH+39LQIHFWLRQZDVVHHQLQDGRXEOHLQDQGPXOWLSOH+39LQIHFWLRQV !W\SHV LQRIWKH+39SRVLWLYHWXPRXUVDPSOHV7KHPRVWFRPPRQ+39 W\SHZDV+39SUHVHQWLQRIDOOWXPRXUVDPSOHVIROORZHGE\VLPXOWDQHRXV +39DQG DQG+39DORQH ,QWRWDORIWKHSDWLHQWVZHUH LQIHFWHGE\HLWKHURUERWK+39DQG+391RFRUUHODWLRQEHWZHHQ+39VWDWXV QHJYVSRV +39YVQRQ WRWXPRXUH[WHQW S7LVS7 JUDGH * * QRUQRGDOVWDWXV S1RUS1 ZDVREVHUYHG Conclusions: 7KHSUHVHQWVWXG\RI+39SUHYDOHQFHLQSHQLOHFDUFLQRPDLVRQHRI WKHODUJHVW7KHSUHYDOHQFHIRXQG LVKLJKHUWKDQUHSRUWHGLQPRVWRWKHU VWXGLHV$FFRUGLQJWRRXUGDWD+39DQGRUSUHYDOHQFHLQSHQLOHFDUFLQRPDLV FRPSDUDEOHWRZKDWLVVHHQLQFHUYLFDOFDUFLQRPDUDLVLQJWKHTXHVWLRQRIZKDWHᚎHFW +39YDFFLQHFRXOGKDYHRQSHQLOHFDUFLQRPDLQFLGHQFH7KHUHZDVQRVLJQLᚏFDQW FRUUHODWLRQ EHWZHHQ +39 VWDWXV DQG KLVWRSDWKRORJLFDO SDUDPHWHUV VXEVHTXHQWO\ +39KDVQRSURJQRVWLFYDOXHDFFRUGLQJWRRXUGDWD
552
SIGNIFICANCE OF POSITIVE SURGICAL MARGINS IN ORGAN-SPARING SURGERY FOR INVASIVE SQUAMOUS CARCINOMA OF THE PENIS
/DP:0DJULOO'$\UHV%(3HUU\0-$&RUELVKOH\&0:DWNLQ1 1 St George’s Hospital, Dept. of Urology, London, United Kingdom, 2St George’s Hospital, Dept. of Histopathology, London, United Kingdom Introduction & Objectives: 2UJDQVSDULQJ VXUJHU\ LQ WKH WUHDWPHQW RI SHQLOH FDQFHU 6&& UHTXLUHV D FRPSURPLVH EHWZHHQ SUHVHUYDWLRQ RI IXQFWLRQ DQG DFFHSWDEOHFRVPHWLFDSSHDUDQFHZLWKWKHQHHGIRUORFDOFDQFHUFRQWURO7KLVVWXG\ DLPV WR GHWHUPLQH WKH VLJQLᚏFDQFH RI D SRVLWLYH LQYDVLYH VXUJLFDO PDUJLQ DIWHU SHQLOHSUHVHUYLQJ VXUJHU\ DQG WR LGHQWLI\ DSSURSULDWH PDQDJHPHQW VWUDWHJLHV LQ VXFKSDWLHQWV Material & Methods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esults: RXW RI SHQLOH SUHVHUYLQJ SURFHGXUHV ZHUH LGHQWLᚏHG WR KDYH DQ LQYDVLYH SRVLWLYH PDUJLQ )ROORZ XS PRQWKV SDWLHQWV KDG HDUO\ UH UHVHFWLRQ RI ZKRP KDG UHVLGXDO GLVHDVH DQG KDG QR GLVHDVH SDWLHQWV UHTXLUHG IXUWKHU UHVHFWLRQV EHWZHHQ UHUHVHFWLRQV EHIRUH EHLQJ UHQGHUHGGLVHDVHIUHH)RUSDWLHQWVRQVXUYHLOODQFHKDGFRQᚏUPHGUHFXUUHQFH DQG UHPDLQUHFXUUHQFHIUHH Conclusions: )RFDOSRVLWLYHPDUJLQVKDYHDORZUDWHRIUHFXUUHQFHLQRXUVHULHV DQG FRXOG EH REVHUYHG LQLWLDOO\ LI WKHUH LV QR YLVLEOH DEQRUPDOLW\ 7KH UHFXUUHQFH UDWHIRUPRUHH[WHQVLYHPDUJLQVMXVWLᚏHVHDUO\UHUHVHFWLRQ
553
DETECTION OF INGUINAL LYMPH NODE INVOLVEMENT IN PENILE SQUAMOUS CELL CARCINOMA BY 18F-FLUORODEOXYGLUCOSE PET/CT
6FKOHQNHU%*UDW]NH&5HLFK27LONL'6FKQHHGH37LOLQJ5 %DUWHQVWHLQ36LHJHUW66WLHI&*6HLW]0 1 University Hospital Grosshadern Ludwig-Maximilians-University Munich, Dept. of Urology, Munich, Germany, 2Hospital Memmingen, Dept. of Urology, Memmingen, Germany, 3University Hospital Grosshadern Ludwig-Maximilians-University Munich, Dept. of Nuclear Medicine, Munich, Germany, 4University Hospital Grosshadern Ludwig-Maximilians-University Munich, Dept. of Pathology, Munich, Germany Introduction & Objectives: 7RSURVSHFWLYHO\DQDO\]HWKHGLDJQRVWLFDFFXUDF\RI ))'*3(7&7VFDQLQWKHDVVHVVPHQWRILQJXLQDOO\PSKQRGHLQYROYHPHQWLQ SDWLHQWVZLWKLQYDVLYHSHQLOHFDUFLQRPDDVWKHH[WHQWRIO\PSKQRGHLQYROYHPHQWLV WKHPRVWUHOHYDQWSURJQRVWLFIDFWRULQSDWLHQWVZLWKSHQLOHFDQFHU Material & Methods: SDWLHQWV ZLWK LQYDVLYH SHQLOH FDUFLQRPD ZHUH VWDJHG SURVSHFWLYHO\E\))'*3(7&7VFDQ))'*3(7&7VFDQZDVSHUIRUPHG DQG EOLQGO\ HYDOXDWHG E\ WZR QXFOHDU PHGLFLQH SK\VLFLDQV ,Q WRWDO O\PSK QRGH LQYROYHPHQWZDVDVVHVVHGLQLQJXLQDOJURLQV5HIHUHQFHVWDQGDUGZDVHLWKHU KLVWRORJ\RUFOLQLFDOIROORZXSZLWKDPLQLPXPRIPRQWKV PHDQ PRQWKV UDQJH ದPRQWKV Results: )'*3(7&7 VKRZHG D VHQVLWLYLW\ RI DQG D VSHFLᚏFLW\ RI 3RVLWLYHSUHGLFWLYHYDOXH 339 ZDV ZKLOHQHJDWLYHSUHGLFWLYHYDOXH 139 ZDV ,QWZRJURLQVPHWDVWDVLVRIPPDQGPPZHUHPLVVHGE\ 3(7&7VFDQ Conclusions: ))'*3(7&7 LV D SURPLVLQJ VWDJLQJ WRRO LQ DVVHVVLQJ WKH LQJXLQDOO\PSKQRGHLQYROYHPHQWRISDWLHQWVZLWKSHQLOHFDUFLQRPD,QWHJUDWLRQRI