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67. Correction of Anemia in β-Thalassemia Mice with a Lentiviral Vector Encoding a Human β-Globin Gene Is Dependent on Polyclonal Reconstitution with a Majority of Stem Cells with Integrations Supporting Pancellular Expresssion
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67. Correction of Anemia in β-Thalassemia Mice with a Lentiviral V ector Encoding a Human β-Globin Gene Is Vector Dependent on Polyclonal Reconstitution with a Majority of Stem Cells with Integrations Supporting Pancellular Expresssion Suzan Imren,1 Robert Pawliuk,2 Benjamin Cavilla,1 Connie J. Eaves,1 Louis D. Wadsworth,3 Margaret Hale,1 Ronald L. Nagel,4 Mary E. Fabry,4 Philippe Leboulch,2,5,6 R. Keith Humphries.1 1 Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada; 2Genetix Pharmaceutical Ltd, Cambridge, MA, United States; 3Department of Pathology and Laboratory Medicine, Childrens and Women′s Health Centre of BC, Vancouver, BC, Canada; 4Albert Einstein College of Medicine, Bronx, NY, United States; 5Massachusetts Institute of Technology, Cambridge, MA, United States; 6Harvard Medical School and Brigham and Womens Hospital, Boston, MA, United States. ( β"
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68. Detection of Pluripotent Hematopoietic Cells in SCID-X1 Gene Therapy Manfred Schmidt,1 Salima Hacein-Bey,2 Francoise LeDeist,2 Nina Lemke,1 Manuela Wissler,1 Alain Fischer,2 Marina CavazzanaCalvo,2 Christof von Kalle.1,3 1 Internal Medicine I, University of Freiburg, Freiburg, Germany; 2 Unite d′Immunologie et d′Hematologie Pediuatriques, Hopital Necker, Paris, France; 3Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany.
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69. Efficient Selective Enrichment of Hematopoietic Stem Cells T ransduced with MFGS Retrovirus Encoding Transduced Benzyl Guanine Resistant Methylguanine Methyltransferase Linked to Marker Genes or to Therapeutic Chronic Granulomatous Disease Genes Uimook Choi,1 Jordana M. De Leon,1 Harry L. Malech.1 1 Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, MD, United States. -C(/ 1
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