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A response to the letter by F. Worek and P. Eyer
Toxicology Letters 167 (2006) 258
Letter to the Editor
A response to the letter by F. Worek and P. Eyer Dear Editor, To develop a new effective antidote therapy, we are examining the action of oximes as an antidote in organophosphate poisoning. As shown in our paper, it is very important that oximes very easily hydrolyze ASCh. However, we are afraid that the statement “the AChE activity assay with ASCh can be a serious source of error in reactivation studies of oximes” might be too strong as they (F. Eorek and P. Eyer) indicate. We are thankful for their opinions.
DOI of the original article:10.1016/j.toxlet.2006.10.002. 0378-4274/$ – see front matter © 2006 Elsevier Ireland Ltd. All rights reserved. doi:10.1016/j.toxlet.2006.10.004
Koichi Sakurada ∗ Department of First Forensic Science, National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan ∗ Tel.:
+81 4 7135 8001; fax: +81 4 7133 9159 E-mail address: [email protected] 10 October 2006 Available online 20 October 2006
Letter to the Editor
A response to the letter by F. Worek and P. Eyer Dear Editor, To develop a new effective antidote therapy, we are examining the action of oximes as an antidote in organophosphate poisoning. As shown in our paper, it is very important that oximes very easily hydrolyze ASCh. However, we are afraid that the statement “the AChE activity assay with ASCh can be a serious source of error in reactivation studies of oximes” might be too strong as they (F. Eorek and P. Eyer) indicate. We are thankful for their opinions.
DOI of the original article:10.1016/j.toxlet.2006.10.002. 0378-4274/$ – see front matter © 2006 Elsevier Ireland Ltd. All rights reserved. doi:10.1016/j.toxlet.2006.10.004
Koichi Sakurada ∗ Department of First Forensic Science, National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan ∗ Tel.:
+81 4 7135 8001; fax: +81 4 7133 9159 E-mail address: [email protected] 10 October 2006 Available online 20 October 2006