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Abstracts
Volume 15 Number 3 September, 1986
12. 13. 14. 15. 16. 17. 18. 19. 20.
Erythema chronicum migrans 463
migrans Afzelius. Acta Derm Venereol (Stockh) 38:285289, 1958. Sonck CE: Erythema chronicum migrans with multiple lesions. Acta Derrn Venereol (Stockh) 45:34-36, 1965. Scrimenti RJ: Erythema chronicum migrans. Arch Dermatoll02:104-105, 1970. Mast WE, Burrows WM: Erythema chronicum migrans in the United States. JAMA 236:859-860, 1976. Steere AC, Malawista SE, Newman JH, et al: Antibiotic therapy in Lyme disease. Ann Intern Med 93:1-8, 1980. Steere AC, Hutchinson GI, Rahn DW, et al: Treatment of the early manifestations of Lyme disease. Ann Intern Med 99:22-26, 1983. Asbrink E, Olsson I: Clinical manifestations of erythema chronicum migrans Afzelius in 161 patients. Acta Derm Venereol (Stockh) 65:43-52, 1985. Weber K, Puzik A, Becker T: Erythema migrans krankheit. Dtsch Med Wochenschr 108:1182-1190, 1983. Berger BW, Clemmensen OJ, Gottlieb GJ: Spirochetes in lesions of erythema chronicum migrans. Am J DermatopathoI4:555-556, 1982. Benach IL, Bosler EM, Hanrahan JP, et al: Spirochetes isolated from the blood of two patients with Lyme disease. N Engl J Med 308:740-742, 1983.
21. Steere AC, Grodzicki RL, Kornblatt AN, et al: The spirochetal etiology of Lyme disease. N Engl I Med 308:733-740, 1983. 22. Steere AC, Pachner AR, Malawista SE: Neurologic abnormalities of Lyme disease: Successful treatment with high-dose intravenous penicillin. Ann Intern Med 99: 767-772, 1983. 23. Steere AC, Green J, Schoen RT, et al: Successful parenteral penicillin therapy of established Lyme arthritis. N Engl J Med 312:869-874, 1985. 24. Lowhagen GB, Brarson JE, Kaijser B: Penicillin concentrations in cerebrospinal fluid and serum after intramuscular, intravenous, and oral administration to syphilitic patients. Acta Derm Venereol (Stockh) 63:53-57, 1983. 25. Ducas J, Robson HG: Cerebrospinal fluid penicillin levels during therapy for latent syphilis. JAMA 246:2583-2584, 1981. 26. Dunlop EM, AI-Egaily SS, Horiang ET: Penicillin levels in blood and CSF achieved by treatment of syphilis. JAMA 241:2538-2540, 1979. 27. Johnson SE, Klein GC, Schmid GP, et al: Susceptibility of the Lyme disease spirochete to seven antimicrobial agents. Yale J BioI Med 57:549-553, 1984.
ABSTRACTS Eruptive elastolysis: A new manifestation of pancreatic carcinoma Slater DN, Messenger A: J R Soc Med 79:237-239, 1986 A 65-year-Old man developed a papular eruption that was histo-
logically characterized by absence of dermal elastic fibers. The onset was simultaneous with clinical manifestations of pancreatic adenocarcinoma, and the authors suggest that the "eruptive elastolysis" resulted from release of pancreatic elastase. J. Graham Smith, Jr., M.D. Photosensitivity reactions associated with nifedipine Thomas SE, Wood ML, et al: Br Med J 292:992, 1986 Two patients developed a photodermatitis associated with nifedipine administration. J. Graham Smith, Jr., MD. Reasons for poor prognosis in British patients with cutaneous malignant melanoma Doherty YR, MacKie RM: Br Med J 292:987-989, 1986 A public education campaign was launched in the west of Scotland in June of 1985 to improve recognition of early malignant melanoma. The proportion of patients with primary melanomas characterized as "thin, good prognosis" had risen from 38% to 62% and the proportion with tumors categorized as "thick, poor prognosis" had fallen from 34% to 15% after only 6 months. J. Graham Smith. Jr., M.D.
Topical prostaglandin E z for chronic leg ulcers Eriksson G, Johansson C, A1y A: Lancet 1:905, 1986 Two nondiabetic chronic leg ulcers in one patient with arterial disease and another with venous disease were treated with crystalline prostaglandin Ez (PGEz) in a concentration of 1-3 flog/ml in sterile. isotonic saline and dispersed in hydrocolloid granules (DuoDerm). Ulcers were filled with POE:, granules and covered with impermeable adhesive dressing. The ulcers that had not responded to conventional treatment showed 80% reduction in the arterial ulcer in 14 weeks and complete healing of the venous ulcer in 10 weeks. J. Graham Smith, Jr., M.D. Biosynthesis of thromboxane in patients with systemic sclerosis and Raynaud's phenomenon Reilly lAG, Roy L, Fitzgerald GA: Br Med J 292: 10371039, 1986 Excretion of the major urinary thromboxane A2 metabolite was significantly increased in 10 patients with systemic sclerosis, complicated by Raynaud's phenomenon, as compared with 10 age- and sex-matched controls. The metabolite 2,3-dinorcthromboxane Bz was further increased following a cold stimulus to induce vasoconstriction. Since thrombollane is a potent vasoconstrictor and may exacerbate digital vasospasm in Raynaud's phenomenon, compounds preventing its synthesis or inhibiting its action may be useful therapeutically. J. Graham Smith, Jr., M.D.
12. 13. 14. 15. 16. 17. 18. 19. 20.
Erythema chronicum migrans 463
migrans Afzelius. Acta Derm Venereol (Stockh) 38:285289, 1958. Sonck CE: Erythema chronicum migrans with multiple lesions. Acta Derrn Venereol (Stockh) 45:34-36, 1965. Scrimenti RJ: Erythema chronicum migrans. Arch Dermatoll02:104-105, 1970. Mast WE, Burrows WM: Erythema chronicum migrans in the United States. JAMA 236:859-860, 1976. Steere AC, Malawista SE, Newman JH, et al: Antibiotic therapy in Lyme disease. Ann Intern Med 93:1-8, 1980. Steere AC, Hutchinson GI, Rahn DW, et al: Treatment of the early manifestations of Lyme disease. Ann Intern Med 99:22-26, 1983. Asbrink E, Olsson I: Clinical manifestations of erythema chronicum migrans Afzelius in 161 patients. Acta Derm Venereol (Stockh) 65:43-52, 1985. Weber K, Puzik A, Becker T: Erythema migrans krankheit. Dtsch Med Wochenschr 108:1182-1190, 1983. Berger BW, Clemmensen OJ, Gottlieb GJ: Spirochetes in lesions of erythema chronicum migrans. Am J DermatopathoI4:555-556, 1982. Benach IL, Bosler EM, Hanrahan JP, et al: Spirochetes isolated from the blood of two patients with Lyme disease. N Engl J Med 308:740-742, 1983.
21. Steere AC, Grodzicki RL, Kornblatt AN, et al: The spirochetal etiology of Lyme disease. N Engl I Med 308:733-740, 1983. 22. Steere AC, Pachner AR, Malawista SE: Neurologic abnormalities of Lyme disease: Successful treatment with high-dose intravenous penicillin. Ann Intern Med 99: 767-772, 1983. 23. Steere AC, Green J, Schoen RT, et al: Successful parenteral penicillin therapy of established Lyme arthritis. N Engl J Med 312:869-874, 1985. 24. Lowhagen GB, Brarson JE, Kaijser B: Penicillin concentrations in cerebrospinal fluid and serum after intramuscular, intravenous, and oral administration to syphilitic patients. Acta Derm Venereol (Stockh) 63:53-57, 1983. 25. Ducas J, Robson HG: Cerebrospinal fluid penicillin levels during therapy for latent syphilis. JAMA 246:2583-2584, 1981. 26. Dunlop EM, AI-Egaily SS, Horiang ET: Penicillin levels in blood and CSF achieved by treatment of syphilis. JAMA 241:2538-2540, 1979. 27. Johnson SE, Klein GC, Schmid GP, et al: Susceptibility of the Lyme disease spirochete to seven antimicrobial agents. Yale J BioI Med 57:549-553, 1984.
ABSTRACTS Eruptive elastolysis: A new manifestation of pancreatic carcinoma Slater DN, Messenger A: J R Soc Med 79:237-239, 1986 A 65-year-Old man developed a papular eruption that was histo-
logically characterized by absence of dermal elastic fibers. The onset was simultaneous with clinical manifestations of pancreatic adenocarcinoma, and the authors suggest that the "eruptive elastolysis" resulted from release of pancreatic elastase. J. Graham Smith, Jr., M.D. Photosensitivity reactions associated with nifedipine Thomas SE, Wood ML, et al: Br Med J 292:992, 1986 Two patients developed a photodermatitis associated with nifedipine administration. J. Graham Smith, Jr., MD. Reasons for poor prognosis in British patients with cutaneous malignant melanoma Doherty YR, MacKie RM: Br Med J 292:987-989, 1986 A public education campaign was launched in the west of Scotland in June of 1985 to improve recognition of early malignant melanoma. The proportion of patients with primary melanomas characterized as "thin, good prognosis" had risen from 38% to 62% and the proportion with tumors categorized as "thick, poor prognosis" had fallen from 34% to 15% after only 6 months. J. Graham Smith. Jr., M.D.
Topical prostaglandin E z for chronic leg ulcers Eriksson G, Johansson C, A1y A: Lancet 1:905, 1986 Two nondiabetic chronic leg ulcers in one patient with arterial disease and another with venous disease were treated with crystalline prostaglandin Ez (PGEz) in a concentration of 1-3 flog/ml in sterile. isotonic saline and dispersed in hydrocolloid granules (DuoDerm). Ulcers were filled with POE:, granules and covered with impermeable adhesive dressing. The ulcers that had not responded to conventional treatment showed 80% reduction in the arterial ulcer in 14 weeks and complete healing of the venous ulcer in 10 weeks. J. Graham Smith, Jr., M.D. Biosynthesis of thromboxane in patients with systemic sclerosis and Raynaud's phenomenon Reilly lAG, Roy L, Fitzgerald GA: Br Med J 292: 10371039, 1986 Excretion of the major urinary thromboxane A2 metabolite was significantly increased in 10 patients with systemic sclerosis, complicated by Raynaud's phenomenon, as compared with 10 age- and sex-matched controls. The metabolite 2,3-dinorcthromboxane Bz was further increased following a cold stimulus to induce vasoconstriction. Since thrombollane is a potent vasoconstrictor and may exacerbate digital vasospasm in Raynaud's phenomenon, compounds preventing its synthesis or inhibiting its action may be useful therapeutically. J. Graham Smith, Jr., M.D.