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Acualités pharmacologiques. René hazard, editor. Series No 6. Masson et Cie, Paris, 1953, 224 pp. Illustr. 16.5 × 25 cm. Paper bound. uncut. Price Fr. 1,480
510
JOURNAL OF THE
AMERICAN PHARMACEUTICAL ASSOCIATION
tract does not represent the total activity of the crude drug. The results of additional experiments along this line, some site of action studies, and some comparative potency tests involving the recently isolated alkaloid reserpine (I 1-13) will be reported later.
Vol. XLIII, No. 8
effect produced by the d n , , and toxicity studies indicate a high therapeutic index. 5 . T h e experimental evidence suggests that RauwoJja serpentina is worthy of further chemical and pharmacological study.
SUMMARY REFERENCES 1. T h e antihypertensive activity of the alcoholic extracts of nine drug samples from five different varieties of Rauwolfia serfientina was determined. A difference in potency was found t o exist among some of the varieties and among different samples of the same variety. 2. Of the alkaloidal preparations tested, serpentine and the serpentine alkaloidal group were t h e major blood pressure-reducing fractions. 3. Sectioning of the vagi does not alter t h e typical antihypertensive effect of the alcoholic extract. 4. With the exception of several adulterated samples, defecation was the only untoward side I
(1) Clouch, P. W.,an editorial, A n n . Internal Med., 38, 142(1953). (2) Hoobler, S. W., and Dontas, A. S., Pharmocol. Revs., 5,135(1953). (3) Sen, G., and Rose, K., lndian Med. World, 2, 194 (1931). (4) Holt, W.L., and Costello, C . H., Txrs JOURNAL, 43, 144(1954). (5) Nelson J. W. andSchlagel C . A. ibid. 42,324(1953) (6) Siddiqh, S., ’and Siddiqui, R. F., J.’ Indian Chcm: SOL.,8, 667(1931). (7) Schlittler, E.,and Schwarz, H., Helu. Chim. A c f a , 3 3 , 1463(1950). (8) Behren, B.,Arch. Erptl. Pathol. Pharmakol., 140,237 (1929). (9) Hartog, J., Arch. intern. gharmacodynamie, 51, 10 (1935). ( l o ) Chopra, R. N., Gupta, J. C., and Mukherjee. B., Indran J . Med. Research, 21,267(1933). (11) Klobs M.W. Draper M. D. Keller F., and Petracek, F. J., J . h m . Ch&. Soc.,’75,486?(1953): (12) Djerassi, C. M. Gorman M., Nusshaum, A. L.,and Re noso, J.. ibid., 7 5 , b446(195&. 63) Chem. Eng. News, 1953,4886.
Book Notices A History of the College of Pharmacy, Columbia Uni- Actualitts Pharmacologiques. RENB HAZARD,Edioersity. By CHARLESW. BALLARD. Columbia tor. Series No. 6. Masson et Cie, Paris, 1953, 224 pp. Illustr. 16.5 x 25 cm. Paper bound. University Press, New York, 1954. 89 pp. Illustr. 17.5 x 26 cm. Price $2. uncut. Price Fr. 1,480. The author of this book has been associated with Like its predecessors, this annual for 1953 prethe College of Pharmacy of Columbia University for sents reviews on a selected number of topics of timely 47 years, first as a student, then as a professor, and interest. It includes papers on cardiac antifibrilfinally as Dean. He is, therefore, well qualified to lants, on structural relations between sympathomiwrite rz history of the College of Pharmacy. metics and sympatholytics, on pharmacological uses Established in 1829, the College of Pharmacy of of tracer isotopes, on the physicochemical analysis Columbia University was the first in New York of local anesthetics, on the active molecule in pharmaState. Through the years it has exerted considerable ceutical synthesis, on the pharmacodynamic reacinfluence on legislation in the interest of public wel- tion of ganglia, on the properties of thyroid hormone, fare such as the law that requires college graduation and finally on the mechanism of action alkaloids and for licensure to practice pharmacy. Its influence ergot. All these reviews are competently written, was also of considerable importance in the founding and the only drawback of the book is the difficulty of of the AMERICANPHARMACEUTICAL ASSOCIATION, finding the valuable material contained therein when the New York State Pharmaceutical Association, needed. It apparently is not covered by any aband the Conference of Pharmaceutical Faculties stract service in the United States. (now the American Association of Colleges of Pharmacy). In his book, Dr. Ballard traces the role the College Pratique de 1’Hibernothirapie en Chirurgie et en Mtdtcine. By H. LABORITand P. HUGUENARD. has played, clarifies its changes in organization, and Masson et Cie, Paris, 1954. 256 pp. Illustr. portrays the curriculum which has developed from 17 x 25 cm. Paper bound, uncut. Price Fr. an essentially apprenticeship system to a standard 1,400. university course of study. His presentation is of significance not only to graduates of the school, but Artificial hibernation is a new therapeutic apto others interested in the development of pharma- proach to certain pathological conditions, particuceutical education in the United States. larly to traumatic and surgical shock, to some toxic
JOURNAL OF THE
AMERICAN PHARMACEUTICAL ASSOCIATION
tract does not represent the total activity of the crude drug. The results of additional experiments along this line, some site of action studies, and some comparative potency tests involving the recently isolated alkaloid reserpine (I 1-13) will be reported later.
Vol. XLIII, No. 8
effect produced by the d n , , and toxicity studies indicate a high therapeutic index. 5 . T h e experimental evidence suggests that RauwoJja serpentina is worthy of further chemical and pharmacological study.
SUMMARY REFERENCES 1. T h e antihypertensive activity of the alcoholic extracts of nine drug samples from five different varieties of Rauwolfia serfientina was determined. A difference in potency was found t o exist among some of the varieties and among different samples of the same variety. 2. Of the alkaloidal preparations tested, serpentine and the serpentine alkaloidal group were t h e major blood pressure-reducing fractions. 3. Sectioning of the vagi does not alter t h e typical antihypertensive effect of the alcoholic extract. 4. With the exception of several adulterated samples, defecation was the only untoward side I
(1) Clouch, P. W.,an editorial, A n n . Internal Med., 38, 142(1953). (2) Hoobler, S. W., and Dontas, A. S., Pharmocol. Revs., 5,135(1953). (3) Sen, G., and Rose, K., lndian Med. World, 2, 194 (1931). (4) Holt, W.L., and Costello, C . H., Txrs JOURNAL, 43, 144(1954). (5) Nelson J. W. andSchlagel C . A. ibid. 42,324(1953) (6) Siddiqh, S., ’and Siddiqui, R. F., J.’ Indian Chcm: SOL.,8, 667(1931). (7) Schlittler, E.,and Schwarz, H., Helu. Chim. A c f a , 3 3 , 1463(1950). (8) Behren, B.,Arch. Erptl. Pathol. Pharmakol., 140,237 (1929). (9) Hartog, J., Arch. intern. gharmacodynamie, 51, 10 (1935). ( l o ) Chopra, R. N., Gupta, J. C., and Mukherjee. B., Indran J . Med. Research, 21,267(1933). (11) Klobs M.W. Draper M. D. Keller F., and Petracek, F. J., J . h m . Ch&. Soc.,’75,486?(1953): (12) Djerassi, C. M. Gorman M., Nusshaum, A. L.,and Re noso, J.. ibid., 7 5 , b446(195&. 63) Chem. Eng. News, 1953,4886.
Book Notices A History of the College of Pharmacy, Columbia Uni- Actualitts Pharmacologiques. RENB HAZARD,Edioersity. By CHARLESW. BALLARD. Columbia tor. Series No. 6. Masson et Cie, Paris, 1953, 224 pp. Illustr. 16.5 x 25 cm. Paper bound. University Press, New York, 1954. 89 pp. Illustr. 17.5 x 26 cm. Price $2. uncut. Price Fr. 1,480. The author of this book has been associated with Like its predecessors, this annual for 1953 prethe College of Pharmacy of Columbia University for sents reviews on a selected number of topics of timely 47 years, first as a student, then as a professor, and interest. It includes papers on cardiac antifibrilfinally as Dean. He is, therefore, well qualified to lants, on structural relations between sympathomiwrite rz history of the College of Pharmacy. metics and sympatholytics, on pharmacological uses Established in 1829, the College of Pharmacy of of tracer isotopes, on the physicochemical analysis Columbia University was the first in New York of local anesthetics, on the active molecule in pharmaState. Through the years it has exerted considerable ceutical synthesis, on the pharmacodynamic reacinfluence on legislation in the interest of public wel- tion of ganglia, on the properties of thyroid hormone, fare such as the law that requires college graduation and finally on the mechanism of action alkaloids and for licensure to practice pharmacy. Its influence ergot. All these reviews are competently written, was also of considerable importance in the founding and the only drawback of the book is the difficulty of of the AMERICANPHARMACEUTICAL ASSOCIATION, finding the valuable material contained therein when the New York State Pharmaceutical Association, needed. It apparently is not covered by any aband the Conference of Pharmaceutical Faculties stract service in the United States. (now the American Association of Colleges of Pharmacy). In his book, Dr. Ballard traces the role the College Pratique de 1’Hibernothirapie en Chirurgie et en Mtdtcine. By H. LABORITand P. HUGUENARD. has played, clarifies its changes in organization, and Masson et Cie, Paris, 1954. 256 pp. Illustr. portrays the curriculum which has developed from 17 x 25 cm. Paper bound, uncut. Price Fr. an essentially apprenticeship system to a standard 1,400. university course of study. His presentation is of significance not only to graduates of the school, but Artificial hibernation is a new therapeutic apto others interested in the development of pharma- proach to certain pathological conditions, particuceutical education in the United States. larly to traumatic and surgical shock, to some toxic