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EUKARYOTIC TRANSCRIPTION FACTORS Fourth Edition David S. Latchman
Master of Birkbeck, University of London and Professor of Genetics at Birkbeck College and University College London
Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors. THIS VOLUME COVERS: ✦ major families of eukaryotic transcription factors ✦ mechanisms of gene activation and repression ✦ structure-function relationships ✦ their roles in inducible and cell type-specific gene expression ✦ development, differentiation and human diseases including cancer ✦ methods of study in vivo and in vitro
This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality. FROM
REVIEWS OF PREVIOUS EDITIONS:
“... A standard for the genre... presented with great clarity... profusely illustrated... admirably up-to-date.” —THE LANCET
December 2003, Hardback, 384 pp., $75.00/£49.95, ISBN: 0124371787
MOLECULAR BIOLOGY OF B CELLS
ORDERING In the Americas (North, Central & South)
Elsevier Customer Service
Howard Hughes Medical Institute Research Laboratories, The Children’s Hospital, Boston, Massachusetts, U.S.A.
Order Fulfillment Dept. 11830 Westline Drive St. Louis, MO 63146-9938 TEL: +1 800 545 2522 (US & CAN) or +1 314 579 3300 FAX: +1 800 535 9935 (US & CAN) or +1 314 523 5940 E-MAIL: [email protected]
Michael S Neuberger
All Other Countries:
Edited by Tasuku Honjo
Kyoto University, Japan
Frederick W. Alt
MRC Laboratory of Molecular Biology, Protein and Nucleic Acid Chemistry Division, Cambridge, UK
Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.
December 2003, Hardback, 616 pp., $149.95/£99.95, ISBN: 0120536412
Books Customer Service Linacre House, Jordan Hill Oxford, OX2 8DP, UK TEL: +44 1865 474110 FAX: +44 1865 474111 E-MAIL: [email protected]
Secure Ordering Online! http://books.elsevier.com All prices and publication dates subject to change without notice. ©2003 by Elsevier. All Rights Reserved. KC/VA/LS–HA05103L 12/03
Master of Birkbeck, University of London and Professor of Genetics at Birkbeck College and University College London
Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors. THIS VOLUME COVERS: ✦ major families of eukaryotic transcription factors ✦ mechanisms of gene activation and repression ✦ structure-function relationships ✦ their roles in inducible and cell type-specific gene expression ✦ development, differentiation and human diseases including cancer ✦ methods of study in vivo and in vitro
This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality. FROM
REVIEWS OF PREVIOUS EDITIONS:
“... A standard for the genre... presented with great clarity... profusely illustrated... admirably up-to-date.” —THE LANCET
December 2003, Hardback, 384 pp., $75.00/£49.95, ISBN: 0124371787
MOLECULAR BIOLOGY OF B CELLS
ORDERING In the Americas (North, Central & South)
Elsevier Customer Service
Howard Hughes Medical Institute Research Laboratories, The Children’s Hospital, Boston, Massachusetts, U.S.A.
Order Fulfillment Dept. 11830 Westline Drive St. Louis, MO 63146-9938 TEL: +1 800 545 2522 (US & CAN) or +1 314 579 3300 FAX: +1 800 535 9935 (US & CAN) or +1 314 523 5940 E-MAIL: [email protected]
Michael S Neuberger
All Other Countries:
Edited by Tasuku Honjo
Kyoto University, Japan
Frederick W. Alt
MRC Laboratory of Molecular Biology, Protein and Nucleic Acid Chemistry Division, Cambridge, UK
Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.
December 2003, Hardback, 616 pp., $149.95/£99.95, ISBN: 0120536412
Books Customer Service Linacre House, Jordan Hill Oxford, OX2 8DP, UK TEL: +44 1865 474110 FAX: +44 1865 474111 E-MAIL: [email protected]
Secure Ordering Online! http://books.elsevier.com All prices and publication dates subject to change without notice. ©2003 by Elsevier. All Rights Reserved. KC/VA/LS–HA05103L 12/03