AGA Institute and Digestive Disease Week 2008 Program Pages

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION POSTGRADUATE COURSE/SPECIAL SESSION AGA Institute Postgraduate Course 8:15 AM - 12:20 PM 20ABCD San Diego Convention Center

Sp15

Capsule Endoscopy (L109) Norman Marcon

10 San Diego Convention Center

Sp16

WELCOME AND INTRODUCTION

Clinical Problems Caused By Gastrointestinal Hormones (L116) Robert T. Jensen 26B

San Diego Convention Center

8:15 Sp1

Introduction Prateek Sharma

8:15 Sp2

Welcome from the AGA Institute President Nicholas F. LaRusso

Sp17

2 San Diego Convention Center

Sp18

Chair: Prateek Sharma

Esophageal Physiology and Function Testing 2008 Peter J. Kahrilas

8:50 Sp4

Beyond PPI's in GERD: What to Do Next? John Dent

9:10 Sp5

H. pylori, Gastritis and Gastric Cancer: Bacterial, Host and Environmental Factors M. Brian Fennerty

9:30 Sp6

Minimizing GI Risk in NSAID and ASA Users Loren A. Laine

9:50 Sp7

Controversy: Management of Dysplasia in Barrett's Esophagus Richard E. Sampliner

10:10

Refreshment Break

Endoscopic Diagnosis and Management of Chronic Pancreatitis (L114) Jacques M. Deviere

25 San Diego Convention Center

SESSION I: MOVING DOWN THE ESOPHAGUS 8:30 Sp3

Drug-Induced Liver Disease (L117) Laurie D. DeLeve

Sp19

Eosinophilic Esophagitis (L101) David A. Katzka

31BC San Diego Convention Center

Sp20

ERCP: Difficult Cannulations Made Easy (L102) Guido Costamagna

4 San Diego Convention Center

Sp21

Extra Esophageal GERD: Fact or Fiction (L113) John M. Inadomi

31A San Diego Convention Center

Sp22

Functional Dyspepsia: Evidence-Based Management (L110) William D. Chey 33BC

San Diego Convention Center Sp23

Chair: Helen M. Shields

Hemorrhoids, Fissures and Fecal Incontinence (L103) 8 Satish S. Rao

San Diego Convention Center

SESSION II: BEYOND THE PYLORUS Sp24

10:40 Sp8

Celiac Sprue: Over or Under Diagnosis? Sheila E. Crowe

11:00 Sp9

Irritable Bowel Syndrome: Putting the ROME Criteria Into Practice Charlene M. Prather

Sp25

11:20 Sp10

Chronic Diarrhea: What's New Henry J. Binder

Sp26

11:40 Sp11

Clostridium difficile Colitis: Emergence of New Strains and Novel Therapies Ciaran Kelly

Sp27

12:00 Sp12

11 San Diego Convention Center

Non-Variceal Upper GI Bleeding (L112) Loren A. Laine

1 San Diego Convention Center

Controversy: Gut Microflora, GI Diseases and Probiotics Michael Camilleri

AGA Institute Postgraduate Course Luncheon Breakout Sessions 12:30 PM - 1:30 PM

Non-Alcoholic Fatty Liver Disease (L108) Nathan M. Bass

PBC and PSC (L115) John M. Vierling Women's Health (L106) Jacqueline L. Wolf

32AB San Diego Convention Center 7A San Diego Convention Center

AGA Institute Postgraduate Course 1:45 PM - 4:00 PM 20ABCD San Diego Convention Center Chair: Maria T. Abreu

Sp13

Autoimmune Pancreatitis (L105) Scott M. Tenner

26A San Diego Convention Center

Sp14

Barrett's Esophagus: Screening, Surveillance and Ablation (L107) Stuart J. Spechler

3 San Diego Convention Center

SESSION III: INFLAMMATORY BOWEL DISEASE 1:45 Sp28

New Diagnostic Techniques for IBD: Serology, Imaging and Capsule Asher Kornbluth

1:45 Sp29

Biologics in IBD: First Line Therapy? William J. Sandborn

1:45 Sp30

Surgical Approach to Crohn's Disease John L. Rombeau

P-23

S A T U R D A Y MAY 17

S A T U R D A Y MAY 17

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION 1:45 Sp31

Controversy: Dysplasia in Bid: Screening, Prevention and Treatment David T. Rubin

1:45

Refreshment Break

1:45 Sp32

Role of Genes, Cytokines and Environment in IBD Scott E. Plevy

PRACTICE MANAGEMENT ESSENTIALS FOR PRACTICE MANAGERS/ADMINISTRATORS IN GASTROENTEROLOGY PRACTICES DAY ONE

AGA Institute Postgraduate Course Clinical Challenge Sessions 4:00 PM - 5:30 PM

Participants will be able to: • Inform the GI practice manager/administrator of issues of concern related to the GI practice and how to address the issues; • Prepare the practice manager/administrator for expected changes in the field of gastroenterology; and • Provide a variety of perspectives on major issues affecting gastroenterology.

Sp33

Acute Necrotizing Pancreatitis (C102) Horst Neuhaus, Amit Rastogi

33A San Diego Convention Center

Sp34

Sp35

7:30

Continental Breakfast

8:00 Sp45

Welcome and Overview: The Integrated Digestive Disease Practice / Survival for the Future Joel V. Brill

San Diego Convention Center

8:35 Sp46

Lesson from the Trenches: Is Bigger Better? Michael L. Weinstein

Complex Issues in IBD: Pregnancy, Fistulae, Pouchitis (C101) Maria T. Abreu, William J. Sandborn 25

9:10 Sp47

Legal Issues in Practice Mergers David Klatsky

9:45 Sp48

Panel Discussion “Practice Mergers”/Q&A Lawrence S. Kim

10:00

Break

10:15 Sp49

Report Cards and Quality Dashboards for Gastroenterology John I. Allen

10:50 Sp50

Pay-for-Performance: Busy Work or Doing Good? Marc Leib

11:25 Sp51

Quality: There Is No Other Way Glenn Lichtenberg

12:00 Sp52

Panel Discussion “Quality and Reporting”/Q&A John I. Allen

12:15

Lunch

1:00 Sp53

Imaging and Your Practice: Time to Glow? Brooks D. Cash

1:35 Sp54

Pathology: Business Ventures and Emerging Models Lawrence S. Kim

2:10 Sp55

Stark Issues and Ancillary Services William Sarraille

2:45 Sp56

Panel Discussion “Ancillary Services”/Q&A Joel V. Brill

3:00

Break

3:15 Sp57

Integrative Gastroenterology: Boutique Practice for the Soul Tbd Tbd

3:50 Sp58

The Private Gastroenterology Practice: There Is Life After Medicare Rudolph A. Bedford

4:25 Sp59

Marketing Your Practice Peter S. Donaldson, Kathy J. Sammis

5:00 Sp60

Panel Discussion “Marketing”/Q&A John I. Allen

Chronic Constipation and Colonic Pseudo-Obstruction (C109) Lin Chang, Satish S. Rao 31A

San Diego Convention Center Sp36

Cystic Lesions of the Pancreas (C108) Michael B. Wallace, Mandeep S. Sawhney

32AB San Diego Convention Center

Sp37

Difficult Management Problems in Viral Hepatitis (C104) Emmet B. Keeffe, Norah Terrault 24ABC

San Diego Convention Center Sp38

Endoscopic Diagnosis and Staging of GI Malignancies (C105) Jacques J. Bergman, Paul Fockens 30A

San Diego Convention Center Sp40

Esophageal Motility Disorders (C103) Ajay Bansal, Peter J. Kahrilas

30E San Diego Convention Center

Sp41

Evaluation of Liver Masses (C110) K. Rajender Reddy, Claude B. Sirlin

31BC San Diego Convention Center

Sp42

IBS: New Insights Into Pathogenesis and Therapies (C106) William D. Chey, Charlene M. Prather 33BC

San Diego Convention Center Sp43

Portal Hypertension: Standards of Practice and New Treatments (C107) Guadalupe Garcia-Tsao, Vijay Shah 30C

San Diego Convention Center

P-24

AGA Institute Practice Managers/Administrators Course 7:30 AM - 5:15 PM Elizabeth B & C Manchester Hyatt

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION AASLD Research Highlights 1:00 PM - 5:30 PM

S A T U R D A Y

7B San Diego Convention Center

Chairs: Arthur J. McCullough, Jacquelyn J. Maher AASLD RESEARCH HIGHLIGHTS Participants will be able to: • Be informed about new research judged by experts to be of high impact to the science and practice of hepatology; • Understand and critique current research in hepatology; and • Utilize information from recent research to guide further research and clinical practice. 1:00 Sp61

Cholestatic Liver Disorders Ulrich Beuers

1:25 Sp62

Portal Hypertension Vijay Shah

1:50 Sp63

Liver Fibrosis Hal F. Yee

2:15 Sp64

Pediatric Liver Disorders Saul Karpen

2:40

Panel Discussion

3:00

Break

3:20 Sp65

Steatosis and Steatohepatitis Craig J. McClain

3:45 Sp66

Viral Hepatitis Hari S. Conjeevaram

4:10 Sp67

Hepatobiliary Surgery and Liver Transplantation Douglas W. Hanto

4:35 Sp68

Hepatobiliary Neoplasia Jorge A. Marrero

5:00

Panel Discussion

5:20

Closing Remarks

MAY 17

P-25

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION POSTGRADUATE COURSE/SPECIAL SESSION SSAT Postgraduate Course 8:00 AM - 5:30 PM

28 San Diego Convention Center

Chairs: Myrddin Rees, Jean-Nicolas Vauthey, Thomas J. Howard, Fabrizio Michelassi, David M. Mahvi, Nathaniel J. Soper SSAT POSTGRADUATE COURSE: UNRESOLVED PROBLEMS AND EVOLVING SOLUTIONS IN SURGICAL GASTROENTEROLOGY

S U N D A Y MAY 18

Participants will be able to: • Have a clear understanding of the current evaluation and surgical options to treat colorectal metastases to the liver; understand how to prevent and treat acute bile duct injuries of differing severity; • Manage a wide variety of acute lower GI emergencies; diagnose and manage both benign and malignant bile duct strictures; and • Recognize patterns of esophageal dysmotility and manage selected complications; and manage benign esophageal strictures and perforations. 8:00 Sp69

Welcome and Course Overview John C. Bowen

SESSION I: MULTIMODAL APPROACH TO COLORECTAL LIVER METASTASES 8:10 Sp70

Preopeartive and Intraoperative Mapping of Metastases Reid B. Adams

8:30 Sp71

Liver Anatomy and Surgical Technique Myrddin Rees

8:50 Sp72

Methods to Improve Resectability Jean-Nicolas Vauthey

9:10 Sp73

Ablative Techniques: When and How Michael Choti

9:30 Sp74

Predicting Long-Term Outcome and a Way Forward John S. Bolton

9:50

Case Presentations

SESSION II: ACUTE BILE DUCT INJURIES: OH MY GOD, I'VE CUT THE BILE DUCT 10:10 Sp75

Interactive Course Introduction Thomas J. Howard

10:20 Sp76

Case #1: Acute Injury, Transection of CHD, Recognized Intraoperatively Mark P. Callery

10:40 Sp77

Case #2: Laparoscopic Cholecystectomy, 2-Days Postop, Patient with Abdominal Pain, Low Grade Fevers, Ileus Glen A. Lehman

11:00 Sp78

Case #3: Patient Transferred to Your Care from An Outside Facility, 5 Days Following Laparoscopic Cholecystectomy, Fevers, Hypotension On Dopamine, Has a Large Biloma Identified On Cross Sectional Imaging Matthew S. Johnson

SESSION III: LOWER GI EMERGENCIES: WHERE, WHAT, AND HOW? 11:20 Sp79

Acute Mesenteric Ischemia W. Charles Sternbergh

11:35 Sp80

Lower GI Hemorrhage David W. McFadden

P-26

11:50 Sp81

Colonic Perforations Wai-Lun Law

12:05

Lunch

1:15 Sp82

Fulminant Ulcerative Colitis Alessandro Fichera

1:30 Sp83

Ischemic and C. difficile Colitis Kirk A. Ludwig

1:45

Panel Discussion

SESSION IV: BENIGN AND MALIGNANT BILE DUCT STRICTURES 2:00 Sp84

Introduction David M. Mahvi

2:05 Sp85

PSC: Current Treatment Edward E. Whang

2:20 Sp86

Benign Biliary Strictures: Stent vs. Surgical Therapy Sharon M. Weber

2:35 Sp87

Cholangiocarcinoma: Strategies for the Management of Intrahepatic Cholangiocarcinoma Taylor S. Riall

2:50 Sp88

Hilar Cholangiocarcinoma: Is There Evidence That Hepatic Resection Improves Outcome for Extrahepatic Cholangiocarcinoma? Margo Shoup

3:05

Panel Discussion

SESSION V: BENIGN DISORDERS OF THE ESOPHAGUS 3:15 Sp89

Motility Disorders: Not Enough, Too Much, and Discoordinated Squeeze Ravinder K. Mittal

3:30 Sp90

Recurrent and Advanced Achalasia: Robotic Heller Procedures and When to Resect Santiago Horgan

3:45 Sp91

Pseudoachalasia with Failed Fundoplication: What Now? Nathaniel J. Soper

4:00 Sp92

Esophageal Perforations: What to Do, When? Jeffrey H. Peters

4:15 Sp93

Current Treatment of Diverticula of the Esophagus John G. Hunter

4:30 Sp94

Benign Esophageal Strictures: Non-Operative Options Nicholas J. Shaheen

4:40 Sp95

Benign Esophageal Strictures: Surgical Options Timothy M. Farrell

4:50 Sp96

Caustic Injuries to the Esophagus and Stomach David A. Katzka

5:05

Panel Discussion

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION AGA Institute Practice Managers/Administrators Course 7:30 AM - 12:15 PM Elizabeth B & C Manchester Hyatt Sponsored by: Practice Management & Economics Committee

10:10 Sp111

Pancreatic Cancer: Targeted Chemotherapeutic Options David C. Whitcomb

AGA Institute Postgraduate Course Luncheon Breakout Sessions 12:30 PM - 1:30 PM

PRACTICE MANAGEMENT ESSENTIALS FOR PRACTICE MANAGERS/ADMINISTRATORS IN GASTROENTEROLOGY PRACTICES DAY TWO Sp112

Participants will be able to: • Inform the GI practice manager/administrator of issues or concerns related to the GI practice and how to address the issues; • Prepare the practice manager/administrator for expected changes in the field of gastroenterology; and • Provide a variety of perspectives on major issues affecting gastroenterology. 7:30

Continental Breakfast

7:55 Sp98

Welcome - Day #2 Joel V. Brill

8:00 Sp99

Coding Compliance: Incident to Whom? Cecile M. Katzoff

8:35 Sp100

Coding for Success Kathleen A. Mueller

9:10 Sp101

Office Based Surgery + Accreditation Kathy J. Sammis

9:45 Sp102

Panel Discussion “Compliance and Accreditation”/Q&A Ronald P. Fogel

10:00

Break

10:15 Sp103

Obesity: Surgeons and Gastroenterologists Chomping At the Bit Santiago Horgan

10:50 Sp104

Endoscopic Sedation: Where's the Gas? Talmage Egan

11:25 Sp105

The Aging Gastroenterologist: Prepare for the Challenges Klaus Mergener

12:00 Sp106

26A San Diego Convention Center

Sp113

Sp114

Breakthroughs in Endoscopic Techniques and NOTES (L211) Anthony N. Kalloo 7B

San Diego Convention Center Sp115

Capsule Endoscopy (L209) Norman Marcon

10 San Diego Convention Center

Sp116

Clinical Problems Caused By Gastrointestinal Hormones (L216) 26B Robert T. Jensen

San Diego Convention Center Sp117

Drug-Induced Liver Disease (L217) Laurie D. DeLeve

2 San Diego Convention Center

Sp118

Endoscopic Diagnosis and Management of Chronic Pancreatitis (L214) Jacques M. Deviere

25 San Diego Convention Center

Sp119

Endoscopic Mucosal Resection (L204) Kenneth K. Wang

9 San Diego Convention Center

Sp120

Eosinophilic Esophagitis (L201) David A. Katzka

31BC San Diego Convention Center

Sp121

ERCP: Difficult Cannulations Made Easy (L202) Guido Costamagna

4 San Diego Convention Center

Sp122

Extra Esophageal GERD: Fact or Fiction (L213) John M. Inadomi

31A San Diego Convention Center

Chair: David A. Lieberman SESSION IV: GASTROINTESTINAL CANCERS: WHAT'S NEW?

Barrett's Esophagus: Screening, Surveillance and Ablation (L207) Stuart J. Spechler

3 San Diego Convention Center

Panel Discussion “Practice Challenges”/Q&A Mark H. DeLegge

AGA Institute Postgraduate Course General Session 8:30 AM - 10:35 AM 20ABCD San Diego Convention Center

Autoimmune Pancreatitis (L205) Scott M. Tenner

Sp123

Functional Dyspepsia: Evidence-Based Management (L210) 33BC William D. Chey

San Diego Convention Center

8:30 Sp107

Colon Cancer Screening and Surveillance Douglas K. Rex

8:55 Sp108

FAP and Other High Risk Populations Sapna Syngal

9:20 Sp109

The Rising Incidence of Esophageal Cancer: Genes or Fat? Nicholas J. Shaheen

Sp125

9:45 Sp110

Controversy: CT Colonography: Ready for Screening Patients? Don C. Rockey

Sp126

10:10

Refreshment Break

Sp124

Hemorrhoids, Fissures and Fecal Incontinence (L203) 8 Satish S. Rao

San Diego Convention Center Non-Alcoholic Fatty Liver Disease (L208) Nathan M. Bass

11 San Diego Convention Center

Non-Variceal Upper GI Bleeding (L212) Loren A. Laine

1 San Diego Convention Center

P-27

S U N D A Y MAY 18

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION Sp127

Sp128

PBC and PSC (L215) John M. Vierling Women's Health (L206) Jacqueline L. Wolf

Sp142

32AB San Diego Convention Center

Cystic Lesions of the Pancreas (C208) Michael B. Wallace, Mandeep S. Sawhney

33BC San Diego Convention Center

Sp143

7A San Diego Convention Center

Difficult Management Problems in Viral Hepatitis (C204) Emmet B. Keeffe, Norah Terrault 31BC

San Diego Convention Center

AGA Institute Postgraduate Course General Session 10:40 AM - 12:20 PM 20ABCD San Diego Convention Center

Sp144

Endoscopic Diagnosis and Staging of GI Malignancies (C205) 30A Jacques J. Bergman, Paul Fockens

San Diego Convention Center

Chair: Kenneth R. McQuaid

S U N D A Y MAY 18

Sp145

30E San Diego Convention Center

SESSION V: THE EPIDEMIC OF OBESITY 10:40 Sp129

Fad Diets and Medicines: Do They Work? Samuel Klein

11:00 Sp130

Obesity, Weight Loss and Liver Function Andrea E. Reid

11:20 Sp131

GI Complications of Bariatric Surgery Jacques M. Deviere

11:40 Sp132

Controversy: Nonalcoholic Fatty Liver: Is Any Treatment Worthwhile? Nathan M. Bass

12:00 Sp133

Endoscopic and Surgical Approaches to Weight Loss Anthony N. Kalloo

Chair: J Eileen Hay SESSION VI: HEPATOLOGY 1:45 Sp134

Hepatitis B: Emerging Therapies in 2008 Anna S. Lok

2:12 Sp135

Hepatitis C: Beyond the Standard Responder Norah Terrault

2:39 Sp136

Liver Transplant: Timing, Selection and Survival James F. Trotter

3:06 Sp137

Iron Overload Syndromes: Genetic Testing, Hepcidin and Beyond Bruce R. Bacon

3:33 Sp138

Controversy: Hepatocellular Carcinoma: Is Screening Effective Hashem B. El-Serag

4:00

Refreshment Break

AGA Institute Postgraduate Course Clinical Challenge Sessions 4:00 PM - 5:30 PM

Sp139

Acute Necrotizing Pancreatitis (C202) Horst Neuhaus, Amit Rastogi

33A San Diego Convention Center

Sp140

Chronic Constipation and Colonic Pseudo-Obstruction (C209) 31A Lin Chang, Satish S. Rao

San Diego Convention Center Sp141

Complex Issues in IBD: Pregnancy, Fistulae, Pouchitis (C201) Maria T. Abreu, William J. Sandborn 32AB

San Diego Convention Center

P-28

Esophageal Motility Disorders (C203) Ajay Bansal, Peter J. Kahrilas

Sp146

Evaluation of Liver Masses (C210) K. Rajender Reddy, Claude B. Sirlin

30D San Diego Convention Center

Sp147

IBS: New Insights Into Pathogenesis and Therapies (C206) William D. Chey, Charlene M. Prather

2 San Diego Convention Center

Sp148

Portal Hypertension: Standards of Practice and New Treatments (C207) Guadalupe Garcia-Tsao, Vijay Shah 30C

San Diego Convention Center

ORAL SESSIONS—SCIENTIFIC SESSIONS SCIENTIFIC SESSIONS AGA Institute Focused Clinical Updates 6:45 AM - 8:00 AM

AASLD Clinical Symposium 8:30 AM - 10:00 AM

6DE San Diego Convention Center

Chairs: Stephen H. Caldwell, Brent A. Tetri Participants will be able to: • Identify how state of the art and emerging research will impact management of digestive disease conditions; and • Review diagnostic and treatment options for patients with several digestive diseases. Sp149

Colorectal Cancer Screening and Surveillance (FC02) Carol A. Burke Annie B

Manchester Hyatt Sp150

Constipation, Pelvic Floor Dysfunction and Anorectal Motility Disorders (FC07) Satish S. Rao Madeline C

Manchester Hyatt Sp151

Sp152

Enhanced Endoscopic Imaging (FC05) Michael B. Wallace

Madeline A Manchester Hyatt

Heartburn: GERD, NERD or Something Else? (FC01) Ronnie Fass Annie A

Manchester Hyatt Sp153

Sp154

Hepatitis C (FC06) Helen S. Te

Madeline B Manchester Hyatt

Management of Inflammatory Bowel Disease (FC03) Sunanda V. Kane Moshen A

Manchester Hyatt Sp155

Update On H. pylori (FC04) Steven F. Moss

Moshen B Manchester Hyatt

AGA Institute Focused Research Roundtables 6:45 AM - 8:00 AM

DRUG THERAPY FOR NAFLD Participants will be able to: • Describe the primary findings of the major published studies regarding the use of pharmacological agents for NASH; • Describe the potential risks of prescribing currently available agents that might be considered for use in patients with NASH; and • Describe the benefits of non-pharmacological therapy for NASH. 8:30 Sp159

Review of TZD Drug Trials, Discussion of Trials and Biposy Issues Vlad Ratziu

8:50 Sp160

Summary of Other Ongoing or Prior Studies (Urso and Betaine Trials) Manal F. Abdelmalek

9:05 Sp161

TZD Safety Issues Brent A. Tetri

9:20 Sp162

Pro-Con Discussion: Drugs Should Be Used for NASH Zobair M. Younossi

9:35 Sp163

Pro-Con Discussion: Drugs Should Not Be Used for NASH Stephen H. Caldwell

9:50

Panel Discussion

AGA Institute Research Symposium 8:30 AM - 10:00 AM 30A San Diego Convention Center Chairs: Charles D. Howell, James R. Spivey Sponsored by: Liver & Biliary; Clinical Practice

IMMUNOPATHOGENESIS OF HEPATITIS C

Participants will be able to: • Review emerging research based on abstracts submitted to DDW 2008 focused on digestive disease, disorders and conditions. Sp156

Sp157

Pathogenesis of Celiac Disease (FR01) Bana Jabri

Madeline D Manchester Hyatt

Update On Research On NASH and ASH (FR02) Ariel E. Feldstein Ford A

Participants will be able to: • Discuss recent advances in the immunology of viral hepatitis C; • Appreciate novel models for study of chronic hepatitis C; and • Review the science behind potential vaccine and host-viral interactions. 8:30 Sp164

Epidemiology and Natural History of Hepatitis C Virus Infection Kenneth E. Sherman

9:00 Sp165

Hepatitis C Virus: From Replication to Infection Outcome Arash Grakoui

9:30 Sp166

Viral Hepatitis in HCV and HIV Infections Mark S. Sulkowski

Manchester Hyatt ASGE Hands-on 8:00 AM - 12:00 PM

15A San Diego Convention Center

Chair: Christopher J. Gostout ADVANCED IMAGING 8:00 Sp158

Advanced Imaging Haruhiro Inoue, Prateek Sharma, Louis-Michel Wong Kee Song

P-29

S U N D A Y MAY 18

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Symposium 8:30 AM - 10:00 AM 30D San Diego Convention Center

AASLD Topic Forum 8:30 AM - 10:00 AM

Chairs: Roberto De Giorgio, Linda C. Samuelson

Chairs: Michael B. Fallon, Guadalupe Garcia-Tsao

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors; Nutrition & Obesity ; Neurogastroenterology and Motility; Intestinal Disorders; Growth, Development & Aging; Immunology, Microbiology & Inflammatory Bowel Disease

PORTAL HYPERTENSION: CLINICAL AND EXPERIMENTAL 8:30 #7

Decreased Mechanical Resistance in Mesenteric Arteries As Novel Mechanism of Arterial Vasodilation in Chronic Severe But Not Short-Term Portal Hypertensive Rats Reiner Wiest*, Markus Resch, Lukas Moleda, Dierk Endemann, Juergen Schoelmerich

8:45 #8

Risk of Death of Patients Admitted to a Gastroenterology Intensive Care Unit Due to Acute Variceal Bleeding According to Mortality and Survival Predictive Models Helena T. Sousa*, José M. Romãozinho, Bárbara Oliveiros, Manuela Ferreira, Pedro Amaro, Rita Figueirinha, Maximino C. Leitão

9:00 #9

The Relationship Between Hospital Volume and Outcomes of Esophageal Variceal Bleeding Robert P. Myers*, Karen D. Papay, Abdel Aziz M. Shaheen, Gilaad G. Kaplan

9:15 #10

Spontaneous Bacterial Peritonities Prophylaxis Improves Morbidity and Mortality: A Meta-Analysis Sammy Saab*, Jose C. Hernandez, Amanda C. Chi, Myron J. Tong

9:30 #11

Emergence of Sepsis As the Leading Cause of Mortality in Cirrhotics Suraj Naik*, Bhargava N. Gannavarapu, Haripriya Maddur, Don C. Rockey

9:45 #12

Deficiency in Placental Growth Factor Causes a Decreased Porto-Systemic Collateral Vessel Formation in Portal Hypertensive Mice Christophe Van Steenkiste*, Anja M. Geerts, Eline Vanheule, Hans Van Vlierberghe, Filip De Vos, Martine De Vos, Isabelle Colle

INTESTINE AND ADIPOSE TISSUE: THE TALE OF TWO ENDOCRINE ORGANS IN INFLAMMATION

S U N D A Y MAY 18

Participants will be able to: • Describe the role of adipose tissue in the control of neuroendocrine function in response to nutrient, neural and hormonal signaling; • Describe the role of mediators released from the GI tract and adipocytes in the development of insulin resistance and obesity; and • Identify the role of adipocytes in the inflammatory bowel disease. 8:30 Sp167

Inflammatory Mediators Released from the Gut Wall and the Microbiome in the Development of Obesity Pauline K. Lund

9:00 Sp168

Adipokines As Modulators of Intestinal Inflammation Giamila Fantuzzi

9:30 Sp169

Visceral Fat and Intestinal Inflammation: An Innocent Bystander or Active Participant? Charalabos Pothoulakis

AASLD Topic Forum 8:30 AM - 10:00 AM

7A San Diego Convention Center

Chairs: Chihiro Morishima, TBD HCV VIROLOGY AND PATHOGENESIS 8:30 #1

HCV Targets TLR7 Receptor Expression By Reducing TLR7 mRNA Stability in HCV Replicating Cells Serena Chang*, Gyongyi Szabo

8:45 #2

Mutations in Epitopes Restricted By Protective HLA A3 and HLA DRB1 0401 Alleles Are Associated with the Development of Persistent Hepatitis C Infection Danijela Petrovic*, Eugene Dempsey, Karen Fitzmaurice, Susan M. McKiernan, Aideen Long, Dermot P. Kelleher

9:00 #3

9:15 #4

9:30 #5

9:45 #6

P-30

Impaired Hepatic Lipid Metabolism By Hepatitis C Virus in Mice and Humans: Implications for Modulation of Transcriptional Processes Michael Kremer*, Arash Nickkholgh, Richard J. Milton, Michael D. Wheeler, Richard A. Rippe, Peter Schemmer, Ian N. Hines A Dramatic Alteration in the Cholesterol Metabolism in An HCV Infected-Liver: The Implications for HCV Infection and Treatment Makoto Nakamuta*, Tatsuya Fujino, Ryoko Yada, Masayoshi Yada, Tsuyoshi Yoshimoto, Ryosuke Takemoto, Kunitaka Fukuizumi, Naohiko Harada, Nobito Higuchi, Masaki Kato, Kazuhiro Kotoh, Munechika Enjoji Steatosis in Chronic Hepatitis C: Changes in Hepatic Fatty Acid Composition Bianca M. Arendt*, Ellie Aghdassi, Saira Mohammed, David W. Ma, Jenny Heathcote, Johane P. Allard Viral Adaptation to Intrahepatic Immune Response in Poor Virologic Responders to Short-Term Peginterferon Plus Ribavirin Treatment for HCV Genotype (Gt) 1 Charles D. Howell*, Chao Huang, Hegang Chen

7B San Diego Convention Center

AGA Institute Research Forum 8:30 AM - 10:00 AM

9 San Diego Convention Center

Chairs: Adam Slivka, John A. Martin Sponsored by: Liver & Biliary

BILIARY TRACT DISORDERS Participants will be able to: • Review top abstracts in the area of biliary tract disorders; and • Discuss new findings regarding gallstone disease and other disorders. 8:30 #13

Physical Activity and Reduced Risk of Symptomatic Gallstones - a Prospective Cohort Study Paul R. Banim*, Kay-Tee Khaw, Nick Wareham, Sheila Bingham, Robert Luben, Andrew Hart

8:45 #14

Gallstone Disease in Swedish Twins is Linked to ABCG8 D19H Risk Genotype Despina Katsika*, Marcin Krawczyk, Stephanie Schwartz, Paul Lichtenstein, Curt A. Einarsson, Frank Lammert, Hanns-Ulrich Marschall

9:00 #15

Decreased Postprandial Gallbladder Emptying in Patients with Black Pigment Stones: A Comparative Study in Patients with Cholesterol Stones and Normal Subjects Kenichi Hakamada*, Shunji Narumi, Yoshikazu Toyoki, Masaki Nara, Keinosuke Ishido, Takuya Miura

ORAL SESSIONS—SCIENTIFIC SESSIONS 9:15 #17

Extrahepatic Cholestasis Increases Liver Stiffness (Fibroscan®) Irrespective of Fibrosis Sebastian Mueller*, Gunda Millonig, Stefanie Friedrich, Andreas Welker, Peter Becker, Frank Reimann, Helmut Karl Seitz

9:30 #18

The Clinical and Radiologic Characteristics of Focal Mass-Forming Autoimmune Pancreatitis Beom Jin Kim*, Jong Kyun Lee, Woo Ik Chang, Won-Seok Choi, Su Rin Shin, Kyu Taek Lee, Jong Chul Rhee, Kee Taek Jang, SeongHo H. Choi

9:45 #19

A Comparative Study of Outcomes Between Endoscopic Naso-Cholecystic Drainage (ENGBD) and Percutaneous Transhepatic Cholecystic Drainage (PTGBD) in Patients with Acute Cholecystitis Byungmoo Yoo*, Min Cheul Kim, Jin Hong Kim

AGA Institute Research Forum 8:30 AM - 10:00 AM

24ABC San Diego Convention Center

AGA Institute Research Forum 8:30 AM - 10:00 AM

Chairs: Sarah E. Keates, John C. Atherton Sponsored by: Esophageal, Gastric & Duodenal Disorders

H. PYLORI AND EPITHELIAL CARCINOGENIC RESPONSES Participants will be able to: • Recognize the mechanisms that regulate H. pylori-induced gastric cancers. 8:30 #26

E-Cadherin and cagA Associate in a Tetrameric Complex That Suppresses Helicobacter pylori-Mediated Cell Invasion Maria J. Oliveira, Angela M. Costa, Ana C. Costa, Jose C. Machado, Raquel Seruca, Marc Mareel, Ceu Figueiredo*

8:45 #27

H. pylori-Mediated Translocation of Peptidoglycan is Required for Microbially-Induced Epithelial Responses that Heighten the Risk for Carcinogenesis Toni Nagy*, Mark R. Frey, Fang Yan, Dawn Israel, D. Brent Polk, Richard M. Peek

9:00 #28

Conditional Deletion of IkappaB Kinase Beta (Ikk-Beta) Accelerates Helicobacter-Dependent Gastric Apoptosis and Preneoplasia Wataru Shibata*, Shigeo Takaishi, Shanisha A. Gordon, Arlin B. Rogers, James G. Fox, Sureshkumar Muthupalani, Melitta Penz-Oesterreicher, Klaus H. Kaestner, Michael Karin, Timothy C. Wang

9:15 #29

Apurinic/Apyrimidinic Endonuclease (APE)-1/Redox Factor (Ref)-1 Is Involved in Gastric Epithelial Cell Survival After H. pylori Infection Ranajoy Chattopadhyay*, Asima Bhattacharyya, Sankar Mitra, Sheila E. Crowe

9:30 #30

Overexpression of Interferon-Gamma in Transgenic Mice Inhibits Helicobacter. felis-Induced Gastric Inflammation and Carcinoma Shuiping Tu*, Guanglin Cui, Shigeo Takaishi, Govind Bhagat, Timothy C. Wang

Chairs: Theresa T. Pizarro, Markus F. Neurath Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

CYTOKINES AND CYTOKINE SIGNALING IN INTESTINAL INFLAMMATION Participants will be able to: • Understand how intracellular signaling regulates cytokine transcription; • Understand how genetic polymorphisms regulate TL1A expression; and • Understand the autocrine regulation of IL-23. 8:30 #20

8:45 #21

9:00 #22

EBI3, a Component of the Regulatory Cytokines IL-27 and IL-35, Contributes to Protective Colonic Immune Responses in Experimental Colitis Stefan J. Wirtz*, Christoph Becker, Richard S. Blumberg, Markus F. Neurath IL-6 Dependent Activation of T Cell in Colitis By Transcription Factor NFATC2 Benno Weigmann*, Hans-Anton Lehr, Stefan Rose-John, Peter R. Galle, Markus F. Neurath NT Induces IL-6 Secretion in Mouse Preadipocytes and Adipose Tissues During TNBS Colitis Hon Wai Koon*, You Sun Kim, Hua Xu, Iordanis Karagiannidis, Dezheng Zhao, Paul Dobner, Charalabos Pothoulakis

9:15 #23

Autocrine Regulation of Interleukin-21 Production in Human Peripheral Blood and Intestinal T Lymphocytes Flavio Caprioli*, Massimiliano Sarra, Roberta Caruso, Carmine Stolfi, Daniele Fina, Giuseppe Sica, Thomas T. MacDonald, Francesco Pallone, Giovanni Monteleone

9:30 #24

TL1A (TNFSF15) Haplotypes Associated with Severe Crohn's Disease (CD) Determine Increased Protein Expression Kathrin S. Michelsen*, Lisa S. Thomas, Kent D. Taylor, Qi Yu, Ling Mei, Carol J. Landers, Carrie A. Derkowski, Jerome I. Rotter, Stephan R. Targan

9:45 #25

TL1A (TNFSF15) Is Involved in the Pathogenesis of Two T Cell-Mediated Chronic Colitis Models Through Modulation of Both TH1 and TH17 Activation Hidetoshi Takedatsu*, Kathrin S. Michelsen, Bo Wei, Carol J. Landers, Lisa S. Thomas, Deepti Dhall, Jonathan Braun, Stephan R. Targan

31BC San Diego Convention Center

9:45 Sp170

State-of-the-Art Overview Emad El-Omar

AGA Institute Research Forum 8:30 AM - 10:00 AM

29 San Diego Convention Center

Chairs: Franck Carbonnel, Charles N. Bernstein Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IMIBD EPIDEMIOLOGY OF IBD Participants will be able to: • Discuss the potential role of linoleic acid in the pathogenesis of ulcerative colitis; • Understand the role of drinking water in the pathogenesis of IBD; and • Describe impact of breast feeding on the maternal disease course in IBD. 8:30 #31

Dietary Linoleic Acid and the Aetiology of Ulcerative Colitis - a European Multi-Centre Prospective Cohort Study Andrew Hart

P-31

S U N D A Y MAY 18

ORAL SESSIONS—SCIENTIFIC SESSIONS

S U N D A Y

8:45 #32

Dietary N-3 Polyunsaturated Fatty Acids Protect Against the Development of Ulcerative Colitis: A UK Prospective Cohort Study Sneha John*, Robert Luben, Ailsa Welch, Hugh J. Kennedy, Kay-Tee Khaw, Sheila Bingham, Andrew Hart

9:00 #33

Water Supply and Inflammatory Bowel Disease Based on a Norwegian Cohort Study from 1990-93 in SouthEastern Norway Geir Aamodt*, Bjorn Moum, Jørgen Jahnsen, Morten H. Vatn

9:15 #34

Is a Light Tobacco Consumption Deleterious in Crohn's Disease? Philippe Seksik*, Isabelle Nion-Larmurier, Laurent Beaugerie, Jacques Cosnes

9:30 #35

9:45 #36

MAY 18

AGA Institute Research Forum 8:30 AM - 10:00 AM

10 San Diego Convention Center

Chairs: Keith A. Sharkey, Aiping Zhao Sponsored by: Neurogastroenterology and Motility

NEUROIMMUNE MODULATION OF GUT FUNCTION Participants will be able to: • Understand neuro-immune regulation of gut function. 8:30 #43

A Population Based Study of Breastfeeding in Inflammatory Bowel Disease: Initiation, Duration and Effect On Disease in the Post Partum Period Dana Moffatt*, Charles N. Bernstein, Alexandra Ilnyckyj

The Role of T Cells in Vagal Protection Against Intestinal Inflammation Caitlin O'Mahony*, Hanneke P. van der Kleij, Fergus Shanahan, John Bienenstock, Liam O'Mahony

8:45 #44

Proximal Extension of Left-Sided Ulcerative Colitis: A Population-Based Study William J. Tremaine*, Lawrence J. Timmons, William S. Harmsen, Alan R. Zinsmeister, Darrell S. Pardi, William J. Sandborn, Edward V. Loftus

Abnormal Immune-Mediated (IL1β/LPS) Regulation of Small Intestinal EC Cell Serotonin Release in Inflammatory Bowel Disease Mark Kidd*, Bjorn I. Gustafsson, Ignat Drozdov, Irvin M. Modlin

9:00 #45

Vagal Nerve Activity Stimulates Endo- and Phagocytosis in Intestinal and Peritoneal Macrophages Via Nicotinic Acetylcholine Receptor Alpha4/Beta2 in Mice Wouter de Jonge*, Sigrid Heinsbroek, Esmerij P. van der Zanden, Susanne A. Snoek, Cathy Cailotto, Guy E. Boeckxstaens, David Greaves, Siamon Gordon

9:15 #46

Plasminogen Activator Inhibitor-2 Plays a Pivotal Role in Host Defense Against Enteric Nematode Infection in Mice Aiping Zhao*, Rex Sun, Jennifer A. Stiltz, Sarah NetzelArnett, Joseph F. Urban, Toni Antalis, Terez Shea-Donohue

9:30 #48

Tumour Necrosis Factor α Activates NFκB to Inhibit NType Voltage-Gated Ca2+ Current in Postganglionic Sympathetic Neurons Mohamed Motagally, Shadi Neshat, Alan Lomax*

AGA Institute Research Forum 8:30 AM - 10:00 AM

4 San Diego Convention Center

Chairs: Barbara H. Jung, Ajay Goel Sponsored by: Gastrointestinal Oncology

MECHANISMS OF METASTASIS AND INVASION OF GASTROINTESTINAL CANCERS Participants will be able to: • Learn more about the invasion of metastasis in GI cancers. 8:30 #37

Cellular Iron Drives In Vitro Proliferation and Migration in Colorectal Adenocarcinoma Matthew J. Brookes*, Keith Roberts, Tariq Iqbal, Chris Tselepis

AGA Institute Research Forum 8:30 AM - 10:00 AM

8:45 #38

Reduced Metastatic Potential of Microsatellite Unstable Colorectal Cancers with hMLH1 Defect, hMSH3 Frameshift Mutations and Ensuing Mutsβ Defects Luigi Laghi*, Paolo P. Bianchi, Gabriele Delconte, Massimo Roncalli, Alberto Malesci

Chairs: Jyoti N. Sengupta, Michael Beyak

9:00 #39

Low-Density of CD3+ Cells At the Invasion Front and Increased Risk of Liver Metastases Development in Microsatellite-Stable Colorectal Cancer Patients Elena Miranda, Emanuela Balladore, Paolo P. Bianchi, Alberto Mantovani, Alberto Malesci, Massimo Roncalli, Luigi Laghi*

9:15 #40

Dichotomous Signaling Mechanisms for Activin-Induced Growth Suppression and Migration in Colon Cancer Cells Barbara H. Jung*, Jennifer Cabral, Jessica Gomez, Stayce E. Beck, John M. Carethers

9:30 #41

Concurrent Mutation of PTEN and Akt2 Overexpression in Colorectal Cancer Increases Micrometastasis Establishment and Growth Piotr G. Rychahou*, Jung-Hee Kang, Hung Q. Doan, Dai H. Chung, B. M. Evers

9:45 #42

Loss of CDx2 Increases Migration and Induces Changes Consistent with Epithelial to Mesenchymal Transition in Human Colon Cancer Cells Sanjay R. Hegde*, Long H. Dang, Duyen Dang, John P. Lynch

P-32

26B San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility

VISCEROSENSORY MECHANISMS AND VISCERAL NOCICEPTION Participants will be able to: • Learn about new mechanisms involved in mechanotransduction; • Learn about the role of spinal and vagal afferents in visceral sensation; and • Learn about new transduction mechanisms of visceral pain. 8:30 #49

Estrogen Rapidly Modulates 5-HydroxytrytophanInduced Visceral Hypersensitivity in Conscious Female Rats Through Gpr30 Receptor, But Not Estrogen Receptor α or β Ching-Liang Lu*, Jen-Chuen Hsieh, Paulus S. Wang, Nae J. Dun, Tudor I. Operea, Full-Young Chang, Shou-Dong Lee

8:45 #50

Novel and Specific Roles for the Ion Channel TRPA1 in Visceral Sensory Transduction Stuart M. Brierley*, Patrick A. Hughes, Amanda J. Page, Tracey A. O'Donnell, Chris M. Martin, Kelvin Y. Kwan, David P. Corey, L. Ashley Blackshaw

9:00 #53

TRPA1 Mediates Bradykinin-Induced Mechanical HyperExcitability in Esophageal Vagal Afferent C Fibers Shaoyong Yu*, Ann Ouyang

ORAL SESSIONS—SCIENTIFIC SESSIONS 9:15 #51

Spinal, Not Vagal Mechanosensitive Afferents Innervate the Rat Pancreas Kate Sutherland, Ann C. Schloithe, Charmaine M. Woods, L. Ashley Blackshaw*, Joseph S. Davison, James Toouli, Gino T. Saccone

11:30 #59

Mass Spectrometric Detection of Lipid Oxidation Products in Murine and Human Nonalcoholic Fatty Liver Disease Tamali Bhattacharyya*, Renliang Zhang, Lisa M. Yerian, Arthur J. McCullough, Stanley L. Hazen, Ariel E. Feldstein

9:30 #52

Symptom Response to a Standardized Nutrient Challenge Test Is Linked to GNB3 C825T Montri Gururatsakul*, Birgit Adam, Tobias Liebregts, Richard H. Holloway, Nicholas J. Talley, Gerald J. Holtmann

11:45 #60

9:45 #54

Mast Cells Play a Pivotal Role in the Development of Pelvic Organ Chronic Sensitization Elena Ustinova, Dmitriy W. Gutkin, Matthew O. Fraser, Michael A. Pezzone*

Transcriptomic Microarray Analysis of the Early Response to Treatment of Hepatitis C Virus (HCV) with Pegylated Interferon and Ribavirin Emma J. Devitt*, Denise Sadlier, John A. Browne, John P. Crowe

AASLD Clinical Symposium 10:30 AM - 12:00 PM

7B San Diego Convention Center

Chairs: Ariel E. Feldstein, Jeffrey Schwimmer EMERGING CONCEPTS IN PEDIATRIC NAFLD Participants will be able to: • Learn about genetic determinants of NAFLD; • Understand the relationship of intrahepatic fat accumulation with the development of the metabolic syndrome in children and adolescents; and • Review the role of invasive and non-invasive tests for diagnosing and monitoring NAFLD in children and have updated information on possible therapeutic strategies for pediatric NAFLD. 10:30

Welcome and Introduction

10:35 Sp171

Genetics / Epidemiology Jeffrey Schwimmer

11:00 Sp172

Fatty Liver and Metabolic Syndrome Sonia Caprio

11:25 Sp173

Diagnosis: Invasive vs. Non-Invasive Anna Wieckowska

11:50

Panel Discussion

AASLD Plenary Session 10:30 AM - 12:00 PM

6F San Diego Convention Center

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM 29 San Diego Convention Center Chairs: Robert J. Fontana, Karen Lindsay Sponsored by: Clinical Practice; Liver & Biliary

ANTIVIRAL AGENTS FOR CHRONIC HBV AND HCV Participants will be able to: • Identify current indications and endpoints for antiviral therapy in patients with chronic HCV and HBV infection; • Summarize the efficacy, safety, and frequency of drug resistance with the currently available oral nucleoside/nucleotide analogues in patients with chronic HBV; and • Describe the current role of pegylated interferon and ribavirin therapy in treatment of Naïve HCV patients as well as potential maintenance therapy in prior non-responders. 10:30 Sp174

Indications and Endpoints for Antiviral Therapy in HBV & HCV Michael W. Fried

10:53 Sp175

Long-Term Management of HBV with Oral Nucleosides/ Nucleotides Norah Terrault

11:16 Sp176

Optimized Pegylated Interferon and Ribavirin Therapy in HCV Mitchell L. Shiffman

11:38 Sp177

Role of Maintenance Interferon Therapy in HCV Robert J. Fontana

Chairs: Jacquelyn J. Maher, Linda Greenbaum

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM 11 San Diego Convention Center

PRESIDENTIAL PLENARY I

Chairs: Yuri A. Saito, William E. Whitehead

10:30 #55

Identifying Acetaminophen (APAP) Toxicity Amongst Indeterminate Cause of Acute Liver Failure (Alf) Niraj Khandelwal*, Laura P. James, Pippa M. Simpson, Timothy J. Davern, Dean W. Roberts, William M. Lee

10:45 #56

Aacetaminophen Hepatotoxicity Is Dependent On TLR9 and Can Be Reduced By a TLR9 Antagonist Shamail Mahmood*, Azuma Watanabe, Muhammad A. Sohail, Richard A. Flavell, Wajahat Z. Mehal

11:00 #57

Sequential Progression of Aberrant Methylation in Cancer-Related Genes in Various Stages of Human Hepatocarcinogenesis Naoshi Nishida*, Takeshi Nagasaka, C. R. Boland, Ajay Goel

11:15 #58

Evidence for a Novel Role for Histamine Regulation of Cholangiocarcinoma Growth By An Autocrine Mechanism Heather Francis*, Sharon DeMorrow, Julie Venter, Shelley Kopriva, Bradley T. Vaculin, Jennifer Savage, Gianfranco Alpini

Sponsored by: Neurogastroenterology and Motility; Esophageal, Gastric & Duodenal Disorders

EMERGING ROLE OF GENETICS IN FUNCTIONAL GASTROINTESTINAL DISORDERS Participants will be able to: • Recognize the genetic basis for various GI functional disorders. 10:30 Sp178

Genetic Mechanisms That Are Common to IBS and Other Chronic Idiopathic Pain Disorders William Maixner

10:52 Sp179

Genetic Markers Associated with the Diagnosis of IBS and Subtypes of IBS William E. Whitehead

11:14 Sp180

Genetic Associations to Brain Imaging Results in FGID: Impact On the Fields of Psychiatry and Functional GI Emeran A. Mayer

P-33

S U N D A Y MAY 18

ORAL SESSIONS—SCIENTIFIC SESSIONS 11:37 Sp181

Pharmacogenomics Michael Camilleri

AGA Institute Committee Sponsored Symposium 10:30 AM - 12:00 PM 30A San Diego Convention Center Chair: James M. Anderson

AGA Institute Research Symposium 10:30 AM - 12:00 PM 33BC San Diego Convention Center Chairs: William M. Grady, Scott K. Kuwada Sponsored by: Gastrointestinal Oncology; Esophageal, Gastric & Duodenal Disorders; Hormones, Transmitters, Growth Factors, & Their Receptors; Growth, Development & Aging

Sponsored by: Research Policy Committee

HOW TO COLLABORATE WITH INDUSTRY-FINDING NEW OPPORTUNITIES IN AN UNSTABLE FUNDING ENVIRONMENT

S U N D A Y MAY 18

Participants will be able to: • Gain knowledge on how to navigate through issues of intellectual properties; • Learn how to develop a research partnership between industry and your institution's interest; and • Obtain research funding and avoid potential issues of ethics and conflicts of interest and learn how to market your research to industry. 10:30 Sp182

How to Find Industry Support for Your Idea Phillip P. Toskes

11:00 Sp183

Connecting Researchers with Biotechnology Companies and Venture Capitalists Duane Roth

11:30 Sp184

Cooperative Agreements: Industry, Academia and the NIH Debra G. Silberg

AGA Institute Committee Sponsored Symposium 10:30 AM - 12:00 PM 4 San Diego Convention Center Chair: Colleen M. Schmitt Sponsored by: Education & Training Committee; Clinical Practice

PURSUING A SUCCESSFUL CAREER IN PRIVATE PRACTICE Participants will be able to: • Appreciate the importance of mentoring and networking and to explore various options in specialty practices; • Learn about remuneration and compensation packages and also learn to navigate the environment of private practice for a successful career; and • Learn to identify and overcome challenges related to gender, race/ ethnicity. 10:30 Sp185

Panel Discussion Mark R. Fleisher

11:00 Sp186

Panel Discussion Joel V. Brill

11:30 Sp187

Panel Discussion Douglas C. Wolf

P-34

TGFβ AND RELATED SIGNALING PATHWAYS IN GI CANCERS Participants will be able to: • Identify the signaling cascades of the TGFβ superfamily of proteins; and • Explain the major alterations in signaling that occur in the TGFβ superfamily within GI cancers. 10:30 Sp188

Adaptor Proteins in TGFβ Signaling and GI Cancer Lopa Mishra

11:00 Sp189

TGFβ, Smads and Colon Cancer R. Daniel Beauchamp

11:30 Sp190

Activin and BMP Signaling in GI Cancer Barbara H. Jung

AGA Institute Translational Symposium 10:30 AM - 12:00 PM 31BC San Diego Convention Center Chairs: Naji N. Abumrad, David D'Alessio Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors; Clinical Practice; Pancreatic Disorders; Liver & Biliary; Esophageal, Gastric & Duodenal Disorders; Growth, Development & Aging; Neurogastroenterology and Motility

BARIATRIC SURGERY, WEIGHT LOSS AND GLUCOSE HOMEOSTASIS: IS IT ALL IN THE HORMONES? Participants will be able to: • Describe the changes in GI hormone levels following gastric bypass surgery; • Identify the possible mechanisms by which gastric bypass surgery improves glucose homeostasis; and • Identify the possible mechanisms by which gastric bypass surgery results in weight loss. 10:30 Sp191

View from the Eye of the Storm: Changes in Hormones Following Gastric Bypass Surgery Naji N. Abumrad

11:00 Sp192

Animal Models of Gastric Bypass Surgery: Mechanisms and Pathways Leading to Weight Loss and Improvement in Glucose Homeostasis Lee M. Kaplan

11:30 Sp193

Gastric Bypass and the Resolution of Type 2 Diabetes Walter J. Pories

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 10:30 AM - 12:00 PM

26B San Diego Convention Center

10:45 #68

Mortality Rate in Patients with Hereditary Pancreatitis (HP), Compared with the French General Population Vinciane Rebours*, Marie-Christine Boutron-Ruault, Valérie Jooste, Anne-Marie Bouvier, Apch Apch, Pascal Hammel, Philippe B. Ruszniewski, Philippe Levy

11:00 #69

Intestinal Current Measurement As a Diagnostic Procedure in Cystic Fibrosis in Infants and Young Children Michael Wilschanski*, Yasmin Yaakov, Gidon Stern, David Shoseyov, Joseph Rivlin, Lea Bentur, Shmuel Goldberg, Edna Shachar, Eitan Kerem

11:15 #70

Lessons from the Secretin Stimulation Test: S-MRCP May Not Be the Best Test to Diagnose Small Duct Chronic Pancreatitis John G. Lieb*, Cynthia W. Garvan, Cheryl W. Curington, Phillip P. Toskes

Chairs: Elie D. Al-Chaer, David R. Linden Sponsored by: Neurogastroenterology and Motility

ANIMAL MODELS OF FUNCTIONAL AND MOTILITY DISORDERS Participants will be able to: • Review advances in use of animal models to understand gastrointrointestinal functional and motility diseases. 10:30 #61

Visceral Hypersensitivity and Altered 5-HT Dynamics in the Intestine of Rats with a Loss of Function Mutation in the Serotonin Transporter James Galligan*, Bhavik A. Patel, Xiaochun Bian, Jaie Wakade, Greg M. Swain

10:45 #62

A Novel Non-Invasive Method to Monitor Gastric Motility in Mice: Role of CRF During Cold Stress Guillaume Gourcerol*, David W. Adelson, Mulugeta Million, Lixin Wang, Yvette Tache

11:00 #63

Altered Intestinal Motility Following Enteric Nervous System Infection By Herpes Simplex Virus 1 Paola Brun*, Maria C. Giron, Chiara Zappellaro, Rosa M. Gaion, Giorgio Palù, Giovanni Zaninotto, Roberto De Giorgio, Ignazio Castagliuolo

11:15 #64

Role of Acetylcholine and Serotonin Receptors in the Maintenance of Muscle Hypercontractility in a Murine Model of Post-Inflammatory Irritable Bowel Syndrome Hirotada Akiho*, Hiroyuki Murao, Haruei Ogino, Kenji Kanayama, Yorinobu Sumida, Shigetaka Yoshinaga, Soichi Itaba, Kazuhiko Nakamura, Ryoichi Takayanagi, Waliul I. Khan, Yohei Tokita, Kazuko Satoh, Mitsue Nishiyama, Atsushi Kaneko, Masahiro Yamamoto

11:30 #65

11:45 #66

Effect of 5-HT2a/2c Receptor Agonist in Maternally Separated Rats Mimicking Irritable Bowel Syndrome Li Gu*, Hasegawa Ryoko, Nakaya Kumi, Yin Fazhi, Motoyori Kanazawa, Shin Fukudo Novel Non-Invasive Method to Assess Colonic Motility in Conscious Mice: Influence of Various Stressors Guillaume Gourcerol*, Lixin Wang, David W. Adelson, Muriel H. Larauche, Yvette Tache, Mulugeta Million

AGA Institute Research Forum 10:30 AM - 12:00 PM

9 San Diego Convention Center

11:30 #71

11:45 #72

CLINICAL CHRONIC PANCREATITIS: DEVELOPMENTS IN DIAGNOSIS AND ETIOLOGY Participants will be able to: • Understand the genetic predisposition and outcomes in chronic pancreatitis; and • Better recognition of the value and limitations of diagnostic approaches to chronic pancreatitis. 10:30 #67

Genetic Defects in the Trypsin Degrading Enzyme Chymotrypsin C (CTRC) Are Associated with Chronic Pancreatitis. Jonas Rosendahl, Heiko Witt, Richard Szmola*, Niels Teich, Miklós Sahin-Tóth

Azathioprine in the Management of Relapsing Autoimmune Pancreatitis/IgG4 Sclerosing Cholangitis Neomal S. Sandanayake, Adrian R. Hatfield, Stephen P. Pereira, George J. Webster*

AGA Institute Research Forum 10:30 AM - 12:00 PM

8 San Diego Convention Center

Chairs: Wael M. El-Rifai, Steven H. Itzkowitz Sponsored by: Gastrointestinal Oncology

GASTRIC CANCER: BIOLOGY, DIAGNOSIS AND TREATMENT Participants will be able to: • Evaluate biology, diagnosis and treatment in gastric cancer. 10:30 #73

Epigenetic Silencing of Dll1 Regulates Notch Activation in Gastric Cancer Lucia Fini*, Melissa Garcia, Michael Selgrad, Sung Kwan Shin, Thomas Jascur, Yuan Yao, Peter Malfertheiner, Thomas Wex, Robert M. Genta, Ajay Goel, Antonia Sepulveda, C. R. Boland, Luigi Ricciardiello

10:45 #74

Spasmolytic Polypeptide Expressing Metaplasia in the Amphiregulin-Deficient Mice Progresses to Intestinal Metaplasia and Invasive Neoplasia Ki-Taek Nam*, Hyuk-Joon Lee, James R. Goldenring

11:00 #75

T-Darpp Induces Tumor Formation In Vivo and Promotes Cancer Cell Survival Through AKT-Dependent Mechanism Abbes Belkhiri*, Altaf Dar, Wael M. El-Rifai

11:15 #76

The IL-6 Family Cytokine IL-11 Regulates Gastric Tumor Growth and Disrupts Homeostatic Epithelial Cell Turnover in the Stomach Meegan Howlett*, Louise M. Judd, Helen Lescescen, Matthias Ernst, Andrew S. Giraud

11:30 #77

The Gastric and Intestinal Mucinous Phenotypes of Gastric Cancers in Human and Helicobacter pyloriInfected and -Eradicated Mongolian Gerbils Tsutomu Mizoshita*, Hiromi Kataoka, Makoto Sasaki, Takaya Shimura, Eiji Kubota, Tsuneya Wada, Takashi Joh

Chairs: Michel Kahaleh, Richard S. Kwon Sponsored by: Pancreatic Disorders

Functional Significance of Endoscopic Ultrasound (EUS) Chronic Pancreatitis (CP) Criteria: Comparison with Secretin and Cholecystokinin (CCK) Pancreatic Function Testing (Pft) Tyler Stevens*, John A. Dumot, Gregory Zuccaro, John J. Vargo, Mansour A. Parsi, Edward D. Purich, Rocio Lopez, Darwin Conwell

P-35

S U N D A Y MAY 18

ORAL SESSIONS—SCIENTIFIC SESSIONS 11:45 #78

High Adenocarcinoma Risk After Diagnosis of Gastric MALT Lymphoma: A Long-Term Nationwide Study Lisette G. Capelle*, Annemarie C. de Vries, Caspar W. Looman, M. K. Casparie, Gerrit A. Meijer, E. J. Kuipers

AGA Institute Research Forum 10:30 AM - 12:00 PM

6C San Diego Convention Center

Chairs: Thomas A. Ullman, Simon Travis

AGA Institute Research Forum 10:30 AM - 12:00 PM

24ABC San Diego Convention Center

Chairs: Peter J. Kahrilas, Michael F. Vaezi

IMIBD ISSUES IN IBD I

Sponsored by: Esophageal, Gastric & Duodenal Disorders

Participants will be able to: • Be familiar with the relationship between Clostridium difficile and IBD; • Be familiar with preliminary data on the efficacy of stem cell transplantation in patients with Crohn's disease; and • Be familiar with the risk factors for development of Crohn's disease following colectomy with ileoanal pouch for ulcerative colitis.

GERD: COMPLICATIONS AND EXTRA-ESOPHAGEAL PRESENTATIONS AND INTERVENTION

S U N D A Y MAY 18

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

Participants will be able to: • Learn about new findings and interventions in GERD complications and presentations. 10:30 #79

Esophageal Eosinophilic Infiltration in Noncardiac Chest Pain Sami R. Achem*, Cristina Almansa, Murli Krishna, Herbert C. Wolfsen, Kenneth R. DeVault, Nicholas J. Talley

10:45 #80

Upper Esophageal Sphincter and Gastroesophageal Junction Pressure Changes Act to Prevent Reflux During Obstructive Sleep Apnea in GERD Patients Shiko Kuribayashi*, Muhammad Hafeezullah, Linda Tatro, Candy Hofmann, Adeyemi Lawal, Syed Q. Hussaini, Jasmohan S. Bajaj, Benson T. Massey, Reza Shaker

11:00 #81

Gastroesophageal Reflux and Esophageal Peristalsis Before and After Gastric Bypass Surgery - An Interim Analysis of Combined Impedance-pH and High Resolution Manometry Data Daniel Pohl*, Markus K. Mueller, Stefan Wildi, Patrick Janiak, Michael Fried, Markus Weber, Radu Tutuian

11:15 #82

Biomechanical Augmentation of the Lower Esophageal Sphincter (LES) Using a Magnetic Sphincter Device Initial Results of a Pilot Trial for the Treatment of GERD Robert A. Ganz*, Daniel H. Dunn, Tom R. DeMeester, John C. Lipham, Luigi Bonavina, Greta Saino, Davide Bona

11:30 #83

11:45 #84

P-36

Effect of the Esophyx Device for Endoluminal Fundoplication On Symptoms, Esophageal Manometry and pH-Impedence of Patients with Gastro-Esophageal Reflux Maura Corsetti*, Sandro M. Passaretti, Salvatore Di Pietro, Gabriele Strini, Antonio Gianluca Castellaneta, Enzo Masci, Benedetto Mangiavillano, Pier A. Testoni A Sham-Controlled Study of Injection of Botulinum Toxin in Diffuse Esophageal Spasm Tim Vanuytsel, Raf Bisschops, Kostas Mimidis, Daniel Sifrim, Lieselot Holvoet, Ingrid Demedts, Joris Arts, Philip Caenepeel, Dominiek De Wulf, Jozef Janssens, Jan F. Tack*

10:30 #85

The Vexed Relationship Between Clostridium difficile and Inflammatory Bowel Disease (IBD) - a Prospective Assessment of Carriage in An Outpatient Setting in Patients in Remission Evelyn M. Clayton*, Mary C. Rea, Fergus Shanahan, Eamonn M. Quigley, Barry Kiely, Reynolds P. Ross, Colin Hill

10:45 #86

Impact of Clostridium Difficile Infection On Pediatric Inflammatory Bowel Disease Filomena Pascarella, Erasmo Miele*, Massimo Martinelli, Emanuela Roscetto, Mariassunta Del Pezzo, Fabio Rossano, Annamaria Staiano

11:00 #87

Clinical Course Following Autologous, Nonmyeloablative, Stem Cell Transplantation in Patients with Refractory Crohn's Disease, 2001-2007 Robert M. Craig*, Richard K. Burt

11:15 #88

The Prevalence of Undiagnosed Disorders of Neutrophil Function Mimicking Crohn's Disease Bu'Hussain Hayee*, Farooq Rahman, Daniel J. Marks, Andrew M. Smith, Stuart L. Bloom, Anthony Segal

11:30 #89

Preoperative Wireless Capsule Endoscopy Does Not Predict Long-Term Outcome After Ileal Pouch-Anal Anastomosis Zuri A. Murrell*, Eric A. Vasiliauskas, Marla C. Dubinsky, Andrew Ippoliti, Gil Y. Melmed, Dermot P. McGovern, Stephan R. Targan, Phillip Fleshner

11:45 #90

Family History of Crohn's Disease Increases the Risk for the Development of Crohn's Disease of Ileal Pouch-Anal Anastomosis Bo Shen*, Feza H. Remzi, Bret Lashner, Elaine Queener, Victor W. Fazio

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 10:30 AM - 12:00 PM

32AB San Diego Convention Center

10:45 #98

Unique Expression of Cytoglobin/Stellate Cell Activation-Associated Protein As An Oxygen Supplier Before Angiogenesis During Gastric Ulcer Healing in Rats Kazunari Tominaga*, Eiji Sasaki, Fumio Tanaka, Tetsuya Tanigawa, Masatsugu Shiba, Kenji Watanabe, Yasuhiro Fujiwara, Nobuhide Oshitani, Norifumi Kawada, Katsutoshi Yoshizato, Tetsuo Arakawa

11:00 #99

Toll-Like Receptors Participate in Gastric Mucosal Protection Through COX-2 and PGE2 Yan Zhang*, Ling Zheng, Terrence Riehl, William Stenson

11:15 #100

Appetite Hormones Ghrelin, Orexin and Obestatin Are Involved in the Mechanism of Gastric Ulcer Healing Tomasz Brzozowski*, Peter C. Konturek, Zbigniew Sliwowski, Michal Pawlik, Agata Ptak-Belowska, Wladyslaw Bielanski, Krystyna Zwirska-Korczala, Stanislaw J. Konturek, Wieslaw W. Pawlik

Chairs: Christian Jobin, David L. Boone Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IN VIVO INTESTINAL TLR ACTIVATION AND SIGNALING Participants will be able to: • Understand how commensal intestinal bacteria stimulate protective mucosal immune responses through TLR activation; • Understand the protective effects of epithelial NFkB activation; and • Understand the role of NOD signaling on mucosal homeostasis. 10:30 #91

10:45 #92

11:00 #93

11:15 #94 11:30 #95

11:45 #96

Generation and Characterization of a Novel Nf-κB Reporter System to Study Bacteria-Host Interactions in the Zebrafish Intestine Marcus Muehlbauer*, Michelle Kanther, Christian Jobin, John F. Rawls T Cell Signaling Via the Toll-Receptor Associated Activator of Interferon (TRIF) Pathway Protects from the Development of Acute and Chronic Murine Colitis Keith J. Breglio*, Masayuki Fukata, Daisy E. Conduah, Yasmin Hernandez, Anli Chen, Tyralee Goo, David Hsu, Ruliang Xu, Maria T. Abreu Toll-Like Receptor Inhibitory Protein (Tollip) Deficiency Is Associated with An Increased Sensitivity to Colitis Eric Bernasconi, Daniel Bachmann, Pierre F. Michetti, Dominique Velin* Intestinal Epithelial Cell-Specific Deletion of Rela Alters the Course of Experimental Murine Colitis Kris A. Steinbrecher*, Eleana Harmel-Laws CARD15/NOD2-/- Mice Exhibit An Hypersensitivity to Ileal Microflora: Role of CD4+ T-Cells, IFNγ and Myosin Light Chain Kinase Frédérick Barreau*, Chrystèle Madre, Dominique Berrebi, Monique Dussaillant, Françoise Merlin, Ghislaine Sterkers, Stephane Bonacorsi, Thecla Lesuffleur, Jean-Pierre Hugot Muramyl Dipeptide Activation of Nucleotide-Binding Oligomerization Domain 2 Protects Mice from Experimental Colitis Tomohiro Watanabe, Naoki Asano, Peter Murray, Keiko Ozato, Atsushi Kitani, Ivan J. Fuss*, Warren Strober

AGA Institute Research Forum 10:30 AM - 12:00 PM

30B San Diego Convention Center

11:30 #101

Impaired Epithelial Restitution in Trefoil Factor 2 (TFF2) Mutant Mice Stomach After Microscopic Damage Lin Xue*, Marshall H. Montrose

11:45 Sp194

State-of-the-Art Overview Mitchell L. Schubert

AGA Institute Research Forum 10:30 AM - 12:00 PM

Sponsored by: Esophageal, Gastric & Duodenal Disorders

10:30 #97

Focal Adhesion Kinase (FAK) Plays a Fundamental Role in Early Polarizing Events in Wound Healing: Elucidating the Requirement of FAK Serine 843 Phosphorylation J. Adrian Lunn*, Rodrigo O. Jacamo, Kristina G. Lee, Enrique Rozengurt

3 San Diego Convention Center

Sponsored by: Liver & Biliary

METABOLIC AND GENETIC LIVER DISEASES Participants will be able to: • Review the latest findings about metabolic and genetic liver diseases; • Discuss new findings regarding niemann pick type C disease; and • Understand the natural history and predictors for non-alcoholic fatty liver disease (NAFLD). 10:30 #102

Treatment of the Liver Disease Associated with Niemann Pick Type C Disease with Ezetemibe and 2Hydroxypropyl Beta Cyclodextrin Results in Near Normalization of ALT and AST Benny Liu*, Stephen D. Turley, John M. Dietschy

10:45 #103

The Role of Cytochrome P-4502e1 in DNA Damage and Ethanol-Mediated Hepatic Carcinogenesis Ying Wang, Sebastian Mueller, Gunda Millonig, J. Nair, H. Bartsch, Helmut-Karl Seitz*

11:00 #104

Nonalcoholic Fatty Liver Disease Is a Marker for Atherogenic Dyslipidemia Takeshi Kimura*, Chihoko Yoshida, Seiju Sasaki, Osamu Takahashi, Sachiko Ohde, Sonoe Hiramatsu

11:15 #105

Downexpression of Intestinal Niemann-Pick C1 Like 1 Protein (NPC1L1) By Ezetimibe Prevents Diet-Induced Fatty Liver Diseases in Mice Helen H. Wang, Piero Portincasa, David Q. Wang*

11:30 #106

Recurrence of Nonalcoholic Steatohepatitis After Liver Transplantation - Frequency and Outcomes Maarouf A. Hoteit*, Kymberly D. Watt, Julie K. Heimbach, Michael R. Charlton

MECHANISMS OF GASTRODUODENAL MUCOSAL RESTITUTION Participants will be able to: • Understand molecular mechanisms that regulate wound healing.

MAY 18

Chairs: Michael Fuchs, Mary E. Rinella

Chairs: Mitchell L. Schubert, Yasutada Akiba

S U N D A Y

P-37

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute GRG Spring Symposium 1:00 PM - 3:30 PM 24ABC San Diego Convention Center

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM 4 San Diego Convention Center

Chair: Rhonda F. Souza

Chairs: Richard S. Kwon, Richard J. Saad

SENESCENCE, AGING, AND CANCER

Sponsored by: Growth, Development & Aging; Clinical Practice; Esophageal, Gastric & Duodenal Disorders

Participants will be able to: • Describe the molecular mechanisms of senescence and its influence on aging and cancer formation.

S U N D A Y MAY 18

ENDOSCOPY IN THE ELDERLY Participants will be able to: • Review and describe clinical aspects of endoscopy relevant to care of the elderly.

1:00 Sp195

Oncogene-Induced Senescence Peiqing Sun

1:50 Sp196

Replicative Senescence Jerry W. Shay

2:15 Sp200

Transnasal Endoscopy in the Elderly Norman Marcon

2:40 Sp197

Aging: Balancing Regeneration and Cancer Judith Campisi

2:45 Sp201

The Evaluation of Biliary and Pancreatic Disease in the Elderly John Baillie

3:15 Sp202

Nurse-Assisted Propofol Use in the Elderly John A. Walker

ASGE Business Meeting 1:30 PM - 2:15 PM

San Diego Ballroom, Columbia 2 Marriott Hotel & Marina

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM 33BC San Diego Convention Center

ASGE BUSINESS MEETING AASLD State-of-the-Art-Lecture 2:15 PM - 3:15 PM

6DE San Diego Convention Center

Chair: T Jake Liang HEPATITIS B: NATURAL HISTORY AND EVOLUTION OF THERAPY Participants will be able to: • Determine which patients with chronic HBV infection are candidates for antiviral therapy; • Compare pros and cons of available drugs and duration of therapy; and • Determine when therapy should be modified for a suboptimal response or development of resistance. 2:15 Sp198

Hepatitis B: Natural History and Evolution of Therapy Emmet B. Keeffe

AGA Institute State-of-the-Art-Lecture 2:15 PM - 3:15 PM 31BC San Diego Convention Center Chair: Randall K. Pearson Sponsored by: Pancreatic Disorders; Growth, Development & Aging

CFTR IN PANCREATIC DISORDERS Participants will be able to: • Discuss the role of CFTR in normal pancreatic physiology; and • Recognize the importance of mutations in CFTR in clinical pancreatitis in adults and children. 2:15 Sp199

P-38

CFTR in Adult Pancreatic Disease Peter R. Durie

Chairs: Louis-Michel Wong Kee Song, Herbert C. Wolfsen Sponsored by: Imaging & Advanced Technology; Esophageal, Gastric & Duodenal Disorders; Clinical Practice; Gastrointestinal Oncology

ENHANCED IMAGING FOR BARRETT'S DYSPLASIA: THE EMERGING ENDO-CYTOSCOPIST Participants will be able to: • Become familiar with emerging technologies for Barrett's dysplasia detection; • Appreciate their opportunities and limitations; and • Consider them in the context of current histopathological analysis. 2:15 Sp203

OCT Norman S. Nishioka

2:38 Sp204

NBI Prateek Sharma

3:01 Sp205

Endocytoscopy David P. Hurlstone

3:23 Sp206

Wherefore the Pathologist Elizabeth A. Montgomery

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Clinical Symposium 2:15 PM - 3:45 PM 6AB San Diego Convention Center

AGA Institute Committee Sponsored Symposium 2:15 PM - 3:45 PM 31A San Diego Convention Center

Chairs: R. Balfour Sartor, Corey A. Siegel

Chair: Don C. Rockey

Sponsored by: Clinical Practice; Intestinal Disorders; Immunology, Microbiology & Inflammatory Bowel Disease; Growth, Development & Aging

Sponsored by: Education & Training Committee

OPTIMIZING THE USE OF BIOLOGICS IN INFLAMMATORY BOWEL DISEASE

Participants will be able to: • Learn the key elements for writing a quality grant proposal; • Describe the grant review process and how study sections work and identify the various research funding sources; and • Learn how to effectively compete for limited resources and maintain your academic career while waiting for renewed funding.

Participants will be able to: • Learn to optimize first and second line therapy in IBD; • Learn the mechanistic and efficacy differences between both commercially available and experimental anti-TNF agents; and • Learn how to monitor and manage safety concerns motivated with biologic therapies in clinical practice. 2:15 Sp207

Biologics in IBD: First or Second Line Therapy? William J. Tremaine

2:45 Sp208

How Do I Choose Amongst the Available Agents? Uma Mahadevan

3:15 Sp209

What Are the Safety Issues with Long Term Therapy? Maria T. Abreu

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM 2 San Diego Convention Center Chairs: Peter J. Kahrilas, Gary W. Falk Sponsored by: Esophageal, Gastric & Duodenal Disorders; Clinical Practice; Neurogastroenterology and Motility

THE PATIENT WITH REFRACTORY GERD: IS IT ALWAYS NERD? Participants will be able to: • Define the advantages and limitations of acid suppression in GERD; • Recognize which test to use to evaluate patient with refractory GERD; and • Learn about non-acid factors in refractory GERD. 2:15 Sp210

How Much PPI Is Enough PPI? David C. Metz

2:38 Sp211

What Test in Which Patient? Peter J. Kahrilas

3:01 Sp212

What Is the Role of Hypersensitivity? Jan F. Tack

3:23 Sp213

When Not to Refer the Patient to Surgery Lars R. Lundell

FUNDING OPPORTUNITIES IN ACADEMIC MEDICINE

2:15 Sp214

The Grant Writing Process Nicholas O. Davidson

2:37 Sp215

The Study Section and Responding to Reviews Rodger A. Liddle

3:00 Sp216

NIH Funding Judith M. Podskalny

3:22 Sp217

Non-NIH Funding John M. Carethers

S U N D A Y MAY 18

AGA Institute Committee Sponsored Symposium 2:15 PM - 3:45 PM 33A San Diego Convention Center Chair: Nicholas J. Shaheen Sponsored by: Education & Training Committee

PURSUING A SUCCESSFUL CAREER IN ACADEMIA Participants will be able to: • Identify the importance of mentoring to the academic career; • Explore various academic career options and determine which is best suited to them; and • Explain the funding and remuneration of academic/research positions; learn how to navigate the academic environment for a successful career; and understand the challenges unique to women and minorities. 2:15 Sp218

How to Succeed As a Clinical Researcher/Panel Discussion Dawn Provenzale

2:45 Sp219

How to Succeed As a Clinical Educator/Panel Discussion Darrell S. Pardi

3:15 Sp220

Clinical Research Investigation/Panel Discussion Christian D. Stone

P-39

ORAL SESSIONS—SCIENTIFIC SESSIONS

S U N D A Y MAY 18

AGA Institute Research Symposium 2:15 PM - 3:45 PM 9 San Diego Convention Center

AGA Institute Translational Symposium 2:15 PM - 3:45 PM 1 San Diego Convention Center

Chairs: Jerrold R. Turner, Kim E. Barrett

Chairs: Stephen M. Collins, Emeran A. Mayer

Sponsored by: Intestinal Disorders; Hormones, Transmitters, Growth Factors, & Their Receptors; Immunology, Microbiology & Inflammatory Bowel Disease; Growth, Development & Aging; Esophageal, Gastric & Duodenal Disorders

Sponsored by: Neurogastroenterology and Motility; Hormones, Transmitters, Growth Factors, & Their Receptors; Esophageal, Gastric & Duodenal Disorders; Clinical Practice; Immunology, Microbiology & Inflammatory Bowel Disease

INTESTINAL BARRIER AND TRANSPORT FUNCTIONS IN HEALTH AND DISEASE

THE MICROBIOME GUT-BRAIN AXIS: IMPLICATIONS FOR FUNCTIONAL GI DISORDERS AND BEYOND

Participants will be able to: • Highlight recent developments in our understanding of the complex interplay between transporters, barrier proteins, immune and microbial effector proteins and mucosal growth; • Identify how barrier is dynamically regulated; and • State the diversity of signaling pathways that lead to barrier and transport dysfunction.

Participants will be able to: • Learn that the gut microbiota can influence the central nervous system and modify behavior; • Recognize that psychosocial pressure on the host influences the gut microbiota; and • Learn that dysbiosis of gut flora (qualitative or quantitative changes in gut bacteria) influences brain function and learn how this expansion of the gut-brain axis can be incorporated into current concepts of functional GI disorders.

2:15 Sp222 2:45 Sp223 3:15 Sp224

The Diverse Functions of Lysophosphatidic Acid in the Gut C. Chris Yun Role and Regulation of Intestinal Epithelial Heat Shock Proteins in Health and Disease Eugene B. Chang Molecular Mechanisms of Intestinal Barrier Dysfunction in Infectious and Inflammatory Conditions Michael Fromm

AGA Institute Translational Symposium 2:15 PM - 3:45 PM 3 San Diego Convention Center

2:15 Sp228

The Ability of Gut Flora to Influence the Host Hypothalamic Pituitary Axis Nobuyuki Sudo

2:38 Sp229

The Impact of Early Life Stress On Bacteria Colonization of the Gut Michael T. Bailey

3:01 Sp230

Does the Brain Recognize the Microbial Content of the Gut? Lisa Goehler

3:23 Sp231

Bug-Brain Crosstalk: Implications for Functional GI Disorders and Beyond Stephen M. Collins

Chairs: Richard M. Green, Frank A. Anania Sponsored by: Liver & Biliary; Clinical Practice; Growth, Development & Aging

GENETICS AND LIVER DISEASE FOR THE PRACTICING PHYSICIAN Participants will be able to: • Learn about the pathogenesis and diagnosis of hemochromatosis; • Appreciate molecular diagnosis in hepatology; and • Learn about the pathogenesis and diagnosis of alpha-1 anti trysin deficiency. 2:15 Sp225

Hemochromatosis: HFE Positive and Negative Kris V. Kowdley

2:45 Sp226

Pediatric Cholestatic Liver Diseases Karan McBride Emerick

3:15 Sp227

Genetic Screening in Clinical Hepatology Practice: Current State and Future Prospects Michael Fuchs

ASGE Clinical Symposium 2:15 PM - 3:45 PM

5 San Diego Convention Center

Chairs: Lawrence S. Friedman, Peter B. Kelsey BARIATRIC SURGERY AND ITS COMPLICATIONS: THE ROLE OF THE ENDOSCOPIST 2:15 Sp232

Endoscopic Management of Complications of Bariatric Surgery Adam Slivka

2:35 Sp233

Surgical Management of Complications of Bariatric Surgery Matthew M. Hutter

2:55 Sp234

Extreme Endoscopy…the Future of Bariatric Surgery Christopher C. Thompson

3:15

Questions & Answers

ASGE Clinical Symposium 2:15 PM - 3:45 PM

6C San Diego Convention Center

Chairs: Janak N. Shah, John A. Martin ENTERAL STENTS: WHO, HOW AND WHAT ARE THE OUTCOMES? 2:15 Sp235

P-40

Esophageal Endoprosthetics Peter D. Siersema

ORAL SESSIONS—SCIENTIFIC SESSIONS 2:32 Sp236

Stents for the Gastric Outlet and Small Bowel Charles E. Dye

2:49 Sp237

Colorectal Endoprosthetics John A. Martin

3:06 Sp238

Extreme Stenting 101: (a) Managing the Difficult Complication, (b) New Frontiers in Stenting Kenneth F. Binmoeller

3:23

2:30 #114

Combination of a Cyclooxygenase (COX)-2 Selective NSAID and a Proton Pump Inhibitor for Prevention of Gastroduodenal Ulcers in Very High Risk Patients: A One-Year, Double-Blind, Randomized Trial Francis K. L. Chan*, Bing-yee Suen, Vincent W. Wong, Justin Wu, Joseph JY Sung

2:45 #116

A Single Tablet Multilayer Formulation of EntericCoated Naproxen Coupled with Non-Enteric-Coated OMEPRAZOLE Is Associated with a Significantly Reduced Incidence of Gastric Ulcers vs. Enteric-Coated Naproxen: A Prospective, Randomized, Double-Blind Study Jay L. Goldstein*, Mark B. Sostek, John G. Fort, Dennis S. Riff, Ying Zhang, John R. Plachetka

3:00 #117

Physicians Fail to Provide Protective Co-Therapy for High GI Risk Patients Taking NSAIDs—Even with Direct Interactive Communication and Free PPI: Results of a Prospective Outcomes Trial Loren A. Laine*, Laurine Connors, Marie R. Griffin, Sean P. Curtis, Christopher P. Cannon

3:15 #118

NSAID-Induced Antral Ulcers Correlate with Distinct Changes in Antral Gene Expression Jay C. Desai*, Tyralee Goo, Masayuki Fukata, Shefali Sanyal, Andrew E. Dikman, Kenneth M. Miller, Lawrence B. Cohen, Andrew Brooks, Maria T. Abreu, James Aisenberg

3:30 Sp238a

NSAID Therapy 2008: The Sum of the Risks Is Greater Than Its Parts James M. Scheiman

Questions & Answers

AASLD Topic Forum 2:15 PM - 3:45 PM

7B San Diego Convention Center

Chairs: Ariel E. Feldstein, Brent A. Tetri ALCOHOLIC AND NONALCOHOLIC STEATOHEPATITIS 2:15 #107

Liver Fibrosis in Diet-Induced Steatohepatitis Is Attenuated By Deficiency in the Expression of Toll-Like Receptor 4 (TLR4), or the TLR Adapter, MyD88 Arumugam Velayudham*, Istvan Hritz, Donna Catalano, Pranoti Mandrekar, Gyongyi Szabo

2:30 #108

NRF2 Prevents Alcohol Induced Fulminant Liver Injury Jutta Lamlé, Silke Marhenke, Jürgen Borlak, Masayuki Yamamoto, Michael P. Manns, Arndt Vogel*

2:45 #109

Primary Alterations in Hepatic Lipid Metabolism Do Not Affect Liver Regeneration Following Partial Hepatectomy Elizabeth P. Newberry*, Susan Kennedy, Yan Xie, Jianyang Luo, Nicholas O. Davidson

3:00 #110

Over Twenty Five Years of Follow Up for a NonAlcoholic Fatty Liver Disease (NAFLD) Cohort Nila Rafiq, Chunhong Bai, Yun Fang, Manirath k. Srishord, Arthur J. McCullough, Zobair M. Younossi*

3:15 #111

Hepatic Lipid Partitioning and Liver Damage in NAFLD: Role of Stearoyl-CoA Desaturase Zhengzheng Li, Michael P. Berk, Ariel E. Feldstein*

3:30 #112

18β-Glycyrrhetinic Acid Prevents Free Fatty Acids/High Fat Diet-Induced Hepatic Toxicity By Inhibiting Cathepsin B Expression and Enzyme Activities Xudong Wu*, Luyong Zhang, Jing Shang, Emily C. Gurley, Elaine Studer, Xuan Wang, Phillip Hylemon, William M. Pandak, Arun J. Sanyal, Huiping Zhou

AGA Institute Research Forum 2:15 PM - 3:45 PM

8 San Diego Convention Center

AGA Institute Research Forum 2:15 PM - 3:45 PM

Chairs: Edward V. Loftus, Daniel Hommes Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IMIBD IMAGING IN IBD: CT, MRI, DBE, AND RADIATION EXPOSURE Participants will be able to: • Be familiar with risk factors for radiation exposure in patients with IBD; • Be familiar with advances in the use of MRI to assess disease activity in colonic Crohn's disease; and • Be familiar with the use of MRI enteroclysis to predict the clinical outcome after surgery for Crohn's disease. 2:15 #119

Crohn's Disease, Surgery and Male Sex Are Risk Factors for Radiation Exposure in Patients with Inflammatory Bowel Disease Zohar Levi*, Rivka Krongrad, Rachel Hazazi, Ofer Benjaminov, Joseph Meyerovitch, Ornit Bar Tal, Yaron Niv, Gerald Fraser

2:30 #120

Crohn's Disease: Factors Associated with Exposure to High Levels of Diagnostic Radiation Alan N. Desmond*, Kevin N. O'Regan, Carmel Curran, Sebastian McWilliams, Michael M. Maher, Fergus Shanahan

2:45 #121

Magnetic Resonance Is a Reliable Technique for Assessment of Disease Activity and Severity in Colonic Crohn Disease Julian Panes*, Jordi Rimola, Sonia Rodríguez, Orlando García-Bosch, Maria Pellisé, Elena Ricart, Montserrat Aceituno, Miquel Sans, Carmen Ayuso, Luís Donoso

Chairs: Francis K. L. Chan, Jay L. Goldstein Sponsored by: Esophageal, Gastric & Duodenal Disorders

EPIDEMIOLOGY AND CLINICAL ISSUES IN NSAIDS Participants will be able to: • Learn about advances in issues related to NSAIDs and related disorders. 2:15 #113

Clinical Impact and Time Trends of Upper and Lower Gastrointestinal Complications Angel I. Lanas*, Luis A. Garcia-Rodriguez, Marta Ponce, Luis Rodrigo, Luis Bujanda, Javier P. Gisbert, Inmaculada Alonso-Abreu, Manuel Castro-Fernandez, Angeles PerezAisa, Mónica Polo-Tomás, Xavier Calvet, Santiago García

29 San Diego Convention Center

P-41

S U N D A Y MAY 18

ORAL SESSIONS—SCIENTIFIC SESSIONS 3:00 #122

3:15 #123

3:30 #124

S U N D A Y MAY 18

Magnetization Transfer MRI Quantitatively Detects Intestinal Fibrosis in ex vivo Human Intestinal Tissue in Crohn's Disease Jeremy Adler*, Scott D. Swanson, Alexandros D. Polydorides, Barbara J. McKenna, Hero K. Hussain, Peter D. Higgins, Christopher P. Golembeski, Ellen M. Zimmermann

AGA Institute Research Forum 2:15 PM - 3:45 PM

Endoscopy and MRI-Enteroclysis Are Similarly Powerful to Predict Clinical Outcome in Patients with Crohn's Disease After Ileocolonic Resection Stavroula Koilakou*, Johannes Sailer, Philipp Peloschek, Harald Vogelsang, Wolfgang Miehsler, Karl Turetschek, Wolfgang Schima, Walter Reinisch

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

High Frequency of Proximal Small Bowel Activity in Crohn's Disease Patients with Previous Distal Activity and Persistent Abdominal Complaints Detected with DBE Peter B. Mensink*, Zuzana Zelinkova, R. L. West, E. J. Kuipers, Christien J. van der Woude

AGA Institute Research Forum 2:15 PM - 3:45 PM

30A San Diego Convention Center

Chairs: Charles O. Elson, Dirk Haller

MICROBIAL-INDUCED INFLAMMATION AND IMMUNOREGULATION Participants will be able to: • Understand how commensal intestinal bacteria stimulate protective mucosal immune responses; • Understand why different strains of E. coli may differentially induce colitis in susceptible hosts; and • Understand how microbial factors activate macrophages and antigen presenting cells. 2:15 #131

Cytomegalovirus (CMV) Induces Nf-κB in Monocytes/ Macrophages: Mechanism for CMV Exacerbation of Inflammatory Bowel Disease (IBD) Phillip D. Smith*, Masako Shimamura, Lois Musgrove, Lea Novak, Ronald H. Clements, William J. Britt, Lesley E. Smythies

2:30 #132

Mechanism of Induction of Inflammatory Bowel Disease Associated Gene TL1A (Tnfsf15) By Microbes in Antigen Presenting Cells David Q. Shih*, Lola Y. Kwan, Elmer Y. Chang, Christopher Chang, Masayuki Saruta, Charles O. Elson, Stephan R. Targan

2:45 #133

Escherichia coli Strains Differentially Induce Colitis in IL-10 Gene Deficient Mice Sandra C. Kim*, Susan L. Tonkonogy, H. W. Jarvis, Arlette Darfeuille-Michaud, R. Balfour Sartor

3:00 #136

Commensal Flora Modulate Natural Regulatory T Cells Development and Onset of Colitis in Germ-Free Samp1/ Yitfc Mice Akira Okazawa*, Hiroshi Tamagawa, Brian K. Reuter, Theresa T. Pizarro, Fabio Cominelli

3:15 #136a

GM-CSF Increases Mucosal Defense to Enteric Pathogens Through Its Activity On Dendritic Cells Yoshihiro Hirata*, Martin F. Kagnoff

3:30 #136b

Enhanced Dendritic Cell (DC) Maturation and Retention in Crohn's Disease Mucosa: Possible Role in Potentiating T Cell Responses to Enteric Bacteria Ernesto R. Drelichman, Lea Novak, Ronald H. Clements, Devin E. Eckhoff, Lois Musgrove, Meg Mosteller-Barnum, Phillip D. Smith, Lesley E. Smythies*

Chairs: Shanthi V. Sitaraman, Christian Jobin Sponsored by: Intestinal Disorders

INTESTINAL INFLAMMATION PHYSIOLOGY Participants will be able to: • Evaluate recent research in intestinal inflammation physiology. 2:15 #125

Conditional Loss of Hepatocyte Nuclear Factor 4alpha Into the Mouse Colon Epithelium Leads to Chronic Intestinal Inflammation Mathieu Darsigny*, Jean-Philippe Babeu, Carine Lussier, Fernand-Pierre Gendron, Emile Levy, Francois Boudreau

2:30 #126

Molecular Identity and Regulation of Na-Adenosine CoTransport During Chronic Intestinal Inflammation Jeff H. Ye*, Steven Coon, Ramesh Kekuda, Uma Sundaram

2:45 #127

Bile Acids Decrease Ileal Mucin During Development of Experimental Necrotizing Enterocolitis Charity A. Reynolds, Ludmila Khailova, Bohuslav Dvorak, Kelly M. Arganbright, Melissa Halpern*

3:00 #128

Acute Regulation of Apical Sodium-Dependent Bile Acid Transporter (ASBT) By Dexamethasone in Human Intestinal Epithelial Cells Pradeep Kumar*, Fadi Annaba, Seema Saksena, Pradeep K. Dudeja, Krishnamurthy Ramaswamy, Ravinder K. Gill, Waddah A. Alrefai

3:15 #129

The Crohn's Disease Candidate Gene Protein Tyrosine Phosphatase N2 (PTPN2) Is Activated By Gamma Interferon (IFNγ) in Intestinal Epithelial Cells (IECs) in An Adenosine-Monophosphate Kinase (Ampk) Dependent Manner Michael Scharl*, Kim E. Barrett, Declan F. McCole

3:30 #130

Activated Innate Immune System in Irritable Bowel Syndrome? Jost Langhorst*, Angela Junge, Andreas Rueffer, Jan Wehkamp, Dirk Foell, Andreas Michalsen, Frauke Musial, Gustav J. Dobos

25 San Diego Convention Center

AGA Institute Research Forum 2:15 PM - 3:45 PM

10 San Diego Convention Center

Chairs: Dino Vaira, Lori A. Fischbach Sponsored by: Esophageal, Gastric & Duodenal Disorders

OPTIMAL STRATEGIES FOR H. PYLORI DIAGNOSIS AND TREATMENT Participants will be able to: • Participants will be able to understand the most effective diagnostic and treatment regimens for H. pylori. 2:15 #137

P-42

Randomized Controlled Comparison of Sequential and Quadruple (Concomitant) Therapies for H. pylori Infection Deng-Chyang Wu*, Ping-I Hsu, Jeng-Yih Wu, Antone R. Opekun, David Y. Graham

ORAL SESSIONS—SCIENTIFIC SESSIONS 2:30 #138

Helicobacter pylori Eradication with Either Conventional 10-Day Triple Therapy or 10-Day Modified Sequential Regimen. (Preliminary Report) Jose R. Ruiz-Obaldía*, Euriko G. Torrazza, Norberto O. Carreno

2:45 #139

A Single Urea Breath Test At 4 Weeks Is As Effective As Two Sequential Breath Tests At 4 and 8 Weeks in Determining the Success of Eradication Therapy for Helicobacter pylori (H Pylori): An Analysis of 454 Patients Nimish Vakil*, Angelo Zullo, Chiara Ricci, Cesare Hassan, Dino Vaira

3:00 #140

Effect of Three Different Regimens with Esomeprazole, Amoxicillin, and Moxifloxacin in the Treatment of Primary H. pylori Infection Flora Sacco, Mariangela Spezzaferro, Mariaelena Serio, Maria Amitrano, Brunella Cerasa, Laurino Grossi, Leonardo Marzio*

3:15 #141

A 20 Hours ELISA Method Chemosusceptibility Rapid Test for Helicobacter pylori Dino Vaira, Federico Perna*

3:30 Sp239

State-of-the-Art Overview Benjamin D. Gold

AGA Institute Research Forum 2:15 PM - 3:45 PM

30E San Diego Convention Center

Chairs: Daniel Chung, Vijay Yajnik

3:30 #147

AGA Institute Topic Forum 2:15 PM - 3:45 PM

Sponsored by: Nutrition & Obesity; Gastrointestinal Oncology

NUTRITION AND CANCER Participants will be able to: • Become familiar with findings in studies on nutrition and its relationship to the pathogenesis and treatment of gastrointestinal and other cancers. 2:15 #148

PLGF Expression By Tumor Stromal Cells Is Induced Via Tumor Cell-Tumor Stromal Crosstalk and Substantially Contributes to Tumor Growth Christian Fischer*, Bart Jonckx, Massimilano Mazzone, Serena Zacchigna, Sonja Loges, Sabine Wyns, Jean Marie Stassen, Mieke Dewerchin, Desire Collen, Peter Carmeliet

2:30 #143

5'-Untranslated Region of the Human VEGF mRNA Has a Novel Tumor-Promoting Function in Human Colon Cancer Cells Kiyoshi Masuda*, Shigetada Teshima-kondo, Yoshiko Nishikawa, Naoko Yamagishi, Kensei Nishida, Hideyuki Sasaki, Kumiko Tominaga, Tomoko Kawai, Keiya Nakamura, Kazuhito Rokutan

2:45 #144

CDx2 Promotes Tumor Pericyte Content and Vascular Function in Human Colon Cancer Xenografts Kyunghee Burkitt, Sang Chun, John P. Lynch, Long H. Dang, Duyen Dang*

3:00 #145

Tumor Derived Colonic Myofibroblasts Promote Enhanced Expansion of CD4+ Cd25High FOXP3+ Regulatory T Cells Via PGE2 Dependent Mechanism Iryna V. Pinchuk*, Jamal I. Saada, Ellen J. Beswick, Gushyalatha Boya, Sahil Mittal, John F. Di Mari, Victor E. Reyes, Don W. Powell

3:15 #146

The Role of Toll-Like Receptor 4 (TLR4) in EpithelialMacrophage Cross-Talk in the Development of Intestinal Neoplasia Masayuki Fukata*, Yasmin Hernandez, Keith J. Breglio, Daisy E. Conduah, Anli Chen, Ruliang Xu, David Hsu, Ryan Ungaro, Maria T. Abreu

Obesity and the Metabolic Syndrome As a Risk Factor in GI Cancers: Colorectal and Esophageal Tumour Cell Survival Is Regulated By Visceral Adipose Tissue Julia M. Howard*, Graham P. Pidgeon, Joanne Lysaght, Darren Ennis, John V. Reynolds

2:30 #149

Resveratrol Sensitizes Colorectal Cancer Cells to Oxaliplatin-Induced Cell Death - Possible Key Role of Inhibitor of Apoptosis Proteins Sandra Ulrich*, Martina Kempf, Jürgen Stein

2:45 #150

Visceral Fat Obesity and Abnormal Glucose Tolerance Correlate with Dysplastic Aberrant Crypt Foci in Colorectal Tumor Free Male Hirokazu Takahashi*, Kyoko Yoneda, Hiroki Endo, Hiroshi Iida, Tomoyuki Akiyama, Yasunobu Abe, Masahiko Inamori, Atsushi Nakajima

3:00 #151

Docosahexaenoic and Eicosahexaenoic N-3 Fatty Acids Inhibit DNA Synthesis and Cell Proliferation in Colorectal Cancer Cells Independent of the Responsible Underlying Molecular Pathways Anna Giros*, Vanessa R. Sapoznik, Jessica FernandezMorales, Rosa M Xicola, Xavier Llor

3:15 #152

Prospective Study of the Effect of Perioperative Immunonutrition with Omega-3 Fatty Acids On Antioxidant Status and Oxidative Damage in OesophagoGastric Cancer Surgery Javed Sultan*, Filippo Di Franco, Irene G. Anderson, Shaun R. Preston, Dayalan Karat, Nick Hayes, Chris Seal, S Michael Griffin

3:30 #153

Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Colorectal Cancer Cell Growth Baogui Wang*, Daniel Prabakaran, M. Michael Wolfe

TUMOR MICROENVIRONMENT

2:15 #142

30C San Diego Convention Center

Chairs: Efi Kokkotou, Luigi Ricciardiello

Sponsored by: Gastrointestinal Oncology

Participants will be able to: • Evaluate recent research in tumor microenvironment.

Aggressive Pancreatic Ductal Adenocarcinoma in Mice Releases Secreted Factors Into the Tumor Microenvironment to Enhance Tumor Progression Hideaki Ijichi*, Masao Omata, Christopher V. Wright, Harold L. Moses

P-43

S U N D A Y MAY 18

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 2:15 PM - 3:45 PM

6F San Diego Convention Center

Chairs: Nicholas J. Talley, Anil Minocha

Chair: James B. McGee

Sponsored by: Clinical Practice; Intestinal Disorders; Neurogastroenterology and Motility

Sponsored by: Education & Training Committee

OUTCOMES RESEARCH IN IRRITABLE BOWEL SYNDROME

MAXIMIZE YOUR CLINICAL PERFORMANCE THROUGH WEB-BASED INTERACTION

Participants will be able to: • Discuss psychological co-morbidity in IBS; • Understand the predictors of work impairment in IBS; and • Discuss the impact of novel therapies for IBS.

S U N D A Y

AGA Institute Committee Sponsored Symposium 2:15 PM - 5:15 PM 26A San Diego Convention Center

2:15 #154

2:30 #155

MAY 18

2:45 #156

3:00 #157

3:15 #158

3:30 #159

Significant Psychological Co-Morbidity Exists in Irritable Bowel Syndrome: A Case-Control Study Using the Irish Hse-Pcrs Pharmacy Reimbursement Database James B. Canavan*, Kathleen Bennett, John Feely, Colm A. O'Morain, Humphrey J. O'Connor Predictors of Work Productivity in Irritable Bowel Syndrome (IBS): Results from the Proof Cohort Brennan M. Spiegel*, Lucinda A. Harris, Susan L. Lucak, Emeran A. Mayer, Bruce D. Naliboff, Roger E. Bolus, Eric Esrailian, William D. Chey, Anthony Lembo, Hetal A. Karsan, Kirsten Tillisch, Gareth S. Dulai, Amy Strickland, Lin Chang Euroqol Utilities Demonstrate Excellent Validity and Responsiveness in IBS: Results from the Proof Cohort Brennan M. Spiegel*, Lucinda A. Harris, Susan L. Lucak, Emeran A. Mayer, Bruce D. Naliboff, Roger E. Bolus, Eric Esrailian, William D. Chey, Anthony Lembo, Hetal A. Karsan, Kirsten Tillisch, Gareth S. Dulai, Amy Strickland, Jennifer Talley, Lin Chang What Symptoms Drive Global Symptom Improvement with Lubiprostone in Patients with Irritable Bowel Syndrome and Constipation: Data from Two Multicenter, Randomized, Placebo-Controlled Trials William D. Chey*, Douglas A. Drossman, Charles Scott, Raymond M. Panas, Ryuji Ueno Relevant Transcriptional Changes After Long-Term Mast Cell Stabilization in the Jejunal Mucosa of DiarrheaProne Irritable Bowel Syndrome (IBS) Cristina Martinez*, Laura Ramos, José Luis Mosquera, Carmen Alonso, Mar Guilarte, María Vicario, Ines de Torres, Francesc Casellas, Esteve Saperas, Javier Santos, Juan R. Malagelada Comprehensive Self-Management for Irritable Bowel Syndrome Works Whether Delivered By Telephone or in-Person Monica Jarrett*, Kevin C. Cain, Vicky Hertig, Robert L. Burr, Sheldon N. Rosen, Margaret Heitkemper

Participants will be able to: • Describe new technologies, devices, and strategies to learn efficiently; • Discuss ways that gastroenterologists can benefit from technology and lifelong learning; and • Apply concepts to identify and improve performance in practice and patient care. 2:15 Sp240

Online Self-Assessment and Maintenance of Certification John F. Kuemmerle

3:00 Sp241

Online Resources for Trainees and Practitioners Geoffrey L. Braden

3:45 Sp242

Lifelong Learning and Professional Development James B. McGee

4:30 Sp243

Licensing & Self-Assessment Robert M. Galbraith

AGA Institute State-of-the-Art-Lecture 4:00 PM - 5:00 PM 25 San Diego Convention Center Chair: Stephen A. Wank Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors; Gastrointestinal Oncology

MUTANT STEM CELLS AND THE FIXATION AND SPREAD OF MUTATIONS IN THE COLON Participants will be able to: • Understand the role of stem cells in tumor growth and differentiation; • Identify the principles of stem cells mutation in colon cancer; and • Explore and devise strategies to study stem cells in relation to gastrointestinal cancer. 4:00 Sp244

Mutant Stem Cells and the Fixation and Spread of Mutations in the Colon Nicholas A. Wright

AASLD Clinical Symposium 4:00 PM - 5:30 PM

6F San Diego Convention Center

Chairs: Nezam Afdhal, Don C. Rockey ELASTOGRAPHY FOR DIAGNOSING LIVER FIBROSIS AND PORTAL HYPERTENSION Participants will be able to: • Understand the pathophysiologic basis of fibrosis and portal hypertension, and how non-invasive techniques such as elastography may detect these processes; • Illustrate the optimal use of elastography in clinical practice; and • Identify the relationships between liver stiffness and portal hypertension and how to utilize this test for variceal screening. 4:00 Sp245

P-44

Pathophysiology of Fibrosis and Biomarkers - Current Status Detlef Schuppan

ORAL SESSIONS—SCIENTIFIC SESSIONS 4:20 Sp246

Elastography and Liver Fibrosis Laurent Castera

4:40 Sp246a

Elastography, Portal Hypertension and Complications of CLD Nezam Afdhal

5:00 Sp247

Elastography in Clinical Practice - Clinical Cases Nezam Afdhal, Don C. Rockey

Sponsored by: Rodger C. Haggitt Gastrointestinal Pathology Society

Panel Discussion

RODGER C. HAGGITT GASTROINTESTINAL PATHOLOGY SOCIETY SESSION: LYNCH SYNDROME - DIAGNOSIS AND SCREENING IN 2008

5:20

AGA Institute Clinical Symposium 4:00 PM - 5:30 PM 6AB San Diego Convention Center Chairs: Joel E. Richter, Ryan D. Madanick Sponsored by: Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Growth, Development & Aging

EOSINOPHILIC ESOPHAGITIS: INSIGHTS ON AN EMERGING CLINICAL ENTITY Participants will be able to: • Identify the clinical presentation and epidemiologic trends in eosinophilic esophagitis; • Recognize the endoscopic manifestations of eosinophilic esophagitis, and the indications for biopsy in subjects presenting with dysphagia; and • Be familiar with the therapeutic options for eosinophilic esophagitis. 4:00 Sp248

Is Incidence Rising, or Is It Better Detection? Ikuo Hirano

4:23 Sp249

The Pathogenic Eosinophil: Where Does GERD Stop and EoE Begin? Wilfred M. Weinstein

4:46 Sp250

Treatment Options Today and Tomorrow Kathryn A. Peterson

5:08 Sp251

Endoscopic Recognition of EoE and Treatment of Strictures Timothy T. Nostrant

AGA Institute Clinical Symposium 4:00 PM - 5:30 PM 29 San Diego Convention Center Chairs: Anthony N. Kalloo, David W. Rattner Sponsored by: Imaging & Advanced Technology; Clinical Practice

NOTES: ADVANCING ON THE FUTURE Participants will be able to: • Be familiar with the emerging field of NOTES; • Appreciate the opportunities for and limitations of NOTES; and • Explain the nuances of research and training in NOTES. 4:00 Sp252

Possibilities for NOTES: Where Are We Going? Lee L. Swanstrom, Mark A. Talamini

4:23 Sp253

Conducting Research in NOTES: How Will We Get There? Michael L. Kochman, Christopher C. Thompson

4:46 Sp254

Training in NOTES: Who Will Take Us? Jeffrey M. Marks, Richard I. Rothstein

5:08 Sp255

NOTES: Where Have We Been and Where Are We Now? Jeffrey L. Ponsky, Robert H. Hawes

AGA Institute Clinical Symposium 4:00 PM - 5:30 PM 1 San Diego Convention Center Chair: Alyssa M. Krasinskas

Participants will be able to: • Learn screening techniques for Lynch Syndrome in newly diagnosed colorectal cancer patients; • Review the morphologic features and mismatch repair protein expression in lynch syndrome cancers; and • Gain knowledge about how to prevent cancer in Lynch Syndrome patients. 4:00 Sp256

Screening for Lynch Syndrome Among Newly Diagnosed Colorectal Carcinoma Patients Heather Hampel

4:30 Sp257

Morphology and Mismatch Repair Proteins of Lynch Syndrome Wendy L. Frankel

5:00 Sp258

Cancer Prevention in Lynch Syndrome Jonathan P. Terdiman

AGA Institute Clinical Symposium 4:00 PM - 5:30 PM 11 San Diego Convention Center Chairs: Samir Parekh, Thomas D. Schiano Sponsored by: Liver & Biliary; Clinical Practice

THE GASTROENTEROLOGIST'S MANAGEMENT OF THE POST-LIVER TRANSPLANT PATIENT Participants will be able to: • Discuss the increased prevalence of malignancy in the post-liver transplant patient; • Be familiar with monitoring ongoing immunosuppression and its associated complications; e.g., hypertension, headache, and metabolic bone disease; and • Review when to refer post-liver transplant patients back to the hepatologist/liver transplant center. 4:00 Sp259

Cancer Screening in Post-Liver Transplant Patients F. Fred Poordad

4:30 Sp260

Care of the Immunosuppressed Liver Transplant Patient in the Community Jacqueline Laurin

5:00 Sp261

When Liver Transplant Patients Should Return to the Transplant Hepatologist Jaquelyn F. Fleckenstein

P-45

S U N D A Y MAY 18

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Committee Sponsored Symposium 4:00 PM - 5:30 PM 9 San Diego Convention Center Chair: Anna S. Lok Sponsored by: International Committee; Clinical Practice; Liver & Biliary

CHANGING FACE OF HEPATITIS B AS A RESULT OF POPULATION MIGRATION

S U N D A Y MAY 18

Participants will be able to: • Learn about the distribution of HBV genotypes in different parts of the world, and relation between HBV genotypes and progression of chronic hepatitis b and response to antiviral therapy; • Appreciate the impact of immigration on the epidemiology of HBV infection in the United States and new CDC recommendations on screening; and • Learn about changes in disease pattern secondary to immigration and implications on management of patients with chronic HBV infection. 4:00 Sp261a

Overview Anna S. Lok

4:15 Sp262

Global Distribution of HBV Genotypes-Implications On Clinical Manifestations and Disease Burden Masashi Mizokami

4:25 Sp263

Immigration and Chronic HBV Infection in the US- Why Prevalence Remains High Despite Decline in Incidence Dale Hu

4:45 Sp264

Changing Face of Chronic HBV Infection in the US Impact On Patient Management Robert P. Perrillo

5:05

4:18 Sp270

Pancreatic Cyst Sampling and Fluid Analysis: Doing It Safely and Making It Count Richard S. Kwon

4:36 Sp271

Novel Endoscopic and Minimally-Invasive Approaches to Management of Cystic Pancreatic Lesions William R. Brugge

4:54 Sp272

Surgical Management of Cystic Pancreatic Lesions: Some, None or All? Carlos Fernandez-del Castillo

5:12

AASLD Topic Forum 4:00 PM - 5:30 PM

5 San Diego Convention Center

ADVANCES IN HCV THERAPY 4:00 #160

Prove2 Study: Treatment of Chronic Hepatitis C with Telaprevir (TVR)in Combination with PeginterferonAlfa-2a with or Without Ribavirin, Interim Analysis Results Christophe Hezode*, Peter Ferenci, Geoffrey M. Dusheiko, Albert Tran, Jean-Didier Grange, Philippe Mathurin, Wolfgang E. Schmidt, Helmut Diepolder, Patrick Marcellin, Heiner Wedemeyer, Nicole Forestier, Wendy Mangels, Shahin Gharakhanian, Robert S. Kauffman, John Alam, Jean-Michel Pawlotsky, Stefan Zeuzem

4:15 #161

Virologic Responses to Pegifnα-2a/Ribavirin in Treatment-Naïve Latino Vs Non-Latino Caucasians Infected with HCV Genotype 1: The Latino Study Maribel Rodriguez-Torres*, Lennox J. Jeffers, Muhammad Y. Sheikh, Lorenzo Rossaro, Victor Ankoma-Sey, Fayez M. Hamzeh, Paul Martin

4:30 #162

Role of Interferon Response During RE-Treatment of Null Responders with Boceprevir Combination Therapy: Results of Phase II Trial Eugene Schiff*, F. Fred Poordad, Ira M. Jacobson, Steven L. Flamm, Bruce R. Bacon, Eric J. Lawitz, Stuart R. Gordon, John G. McHutchison, Reem Ghalib, Thierry Poynard, Mark S. Sulkowski, Christian Trepo, Mario Rizzetto, Stefan Zeuzem, Patrick Marcellin, Tulia Patricia Mendez, Clifford A. Brass, Janice Albrecht

4:45 #163

Variants in Interferon-α Pathway Genes and Response to Treatment of Chronic Hepatitis C Thomas R. O'Brien*, Tania M. Welzel, Herbert L. Bonkovsky, Raymond T. Chung, Deepa Naishadham, Elizabeth C. Wright, Stephen Chanock, Timothy R. Morgan

5:00 #164

Hepatic Gene Trancription Signature Associated with Sustained Virologic Response (SVR) in African (AA) and Caucasian (CA) Americans Infected with HCV Genotype 1 Charles D. Howell*, Chao Huang, Zhenqiu Liu, Hegang Chen

5:15 #165

Polymorphism in the Human MHC and the Early Viral Decline During Treatment of HCV Leland J. Yee*, KyungAh Im, Abdus S. Wahed, Teodorica Bugawan, Jia Li, Shannon L. Rhodes, Henry Erlich, Hugo R. Rosen, T. Jake Liang, HuiYing Yang

Chairs: Marcia I. Canto, Prateek Sharma ENDOSCOPIC IMAGING: “THROUGH THE LOOKING GLASS” 4:00 Sp265

High Resolution, Fluorescence and Contrast Enhanced Endoscopy (NBI-AFI, FICE, EPKi Systems) Prateek Sharma

4:17 Sp266

Endocytoscopy and Confocal Endomicroscopy Ralf Kiesslich

4:34 Sp267

Innovations in Endoscopic Ultrasonography Marc Giovannini

4:51 Sp268

Endoscopic and Molecular Imaging for the Future: The Biomedical Engineer's Wish List Eric J. Seibel

5:10

Questions & Discussion

ASGE Clinical Symposium 4:00 PM - 5:30 PM

6C San Diego Convention Center

Chairs: Michelle A. Anderson, Vanessa M. Shami MANAGEMENT OF CYSTIC PANCREATIC LESIONS 4:00 Sp269

P-46

Imaging in Cystic Lesions of the Pancreas: When and How to Look and Look Again Vanessa M. Shami

6DE San Diego Convention Center

Chairs: Hugo E. Vargas, Reem Ghalib

Discussion

ASGE Clinical Symposium 4:00 PM - 5:30 PM

Questions & Answers

ORAL SESSIONS—SCIENTIFIC SESSIONS AASLD Research Forum 4:00 PM - 5:30 PM

7A San Diego Convention Center

4:15 #173

Reduced Epidermal Growth Factor (EGF) Expression Is Associated with An Increased Risk for the RefluxInduced Cascade Causing Barrett's Esophagus and Esophageal Adenocarcinoma Vivianda Menke*, Peter D. Siersema, Leon M. Moons, Katinka P. van Zoest, Raymond G. Pot, Bettina E. Hansen, Herman van Dekken, Johannes G. Kusters, Ernst J. Kuipers

4:30 #174

Expression of Oncogenic H-RASG12v Does Not Induce Malignant Transformation or Senescence in Barrett's Epithelial Cells. Xi Zhang*, Hui Ying Zhang, Stuart J. Spechler, Rhonda F. Souza

4:45 #175

Sequential Chromosomal Events Leading to HER-2 Proto-Oncogene Amplification in Barrett's Esophagus Rygiel M. Agnieszka, Francesca Milano, Fiebo J. ten Kate, Brenda Elzer, Paul Fockens, Jacques J. Bergman, Maikel P. Peppelenbosch, Kausilia K. Krishnadath*

Chairs: William M. Pandak, Mary E. Rinella BASIC AND TRANSLATIONAL RESEARCH ADVANCES IN BILIARY DISEASE 4:00 #166

Effect of Dietary Cholesterol On Gallbladder Bile Lithogenicity and Gene Expression Profile in the Enetrohepatic Axis of Gallstone and Controls Patients Juan F. Miquel*, Frenando Pimentel, Frank Lammert, Dieter Lütjohann, Lorena Azocar, Hector R. Molina, Ada Cuevas, Soledad Reyes, Marco A. Arrese, Flavio Nervi

4:15 #167

L-Fabp Deletion Increases Susceptibility to Diet-Induced Cholesterol Gallstones Yan Xie*, Elizabeth P. Newberry, Susan Kennedy, Jianyang Luo, Nicholas O. Davidson

4:30 #168

Regulation of Hepatocyte Lipid Metabolism By 25Hydroxycholesterol-3-Sulfate (25hc3s) Is Mediated Via the LXR / SREBP-1 Signaling Pathway Shunlin Ren*, Xiaobo Li, Yongjie Ma, Daniel RodriguezAgudo, Gregorio Gil, Phillip Hylemon, Douglas M. Heuman, William M. Pandak

4:45 #169

5:00 #170

5:15 #171

Trail Receptor Dr5-Mediated Apoptosis Signals Induce Screrosing Cholangiopathy in Mice Kenichi Ikejima*, Kazuyoshi Takeda, Yuko Kojima, Tomonori Aoyama, Kyoko Okumura, Shunhei Yamashina, Ko Okumura, Sumio Watanabe Reactivation of the Hypothalamic-Pituitary-Adrenal Axis By Central Administration of Corticotropin Releasing Hormone Inhibits Cholangiocyte Proliferation During Extrahepatic Cholestasis Tracy Davis, Heather L. Francis, Yoshiyuki Ueno, Monique Stutes, Sharon DeMorrow* Loss of Nm23-H2 and Ncor Interactions with Peroxisome Proliferator-Activated Receptor δ (PPARδ) Promotes Cholangiocarcinoma Growth Xuefeng Xia*, Wenzheng Zhang, Sushma Venugopsl, Yuhua Xiao, Dongbing Gao, Gene LeSage

AGA Institute Research Forum 4:00 PM - 5:30 PM

5:00 #176

Trastuzumab Synergistically Acts with HER-2 Specific Ctls to Induce Tumor Cell Lysis in Esophageal Adenocarcinoma Francesca Milano*, Agnieszka M. Rygiel, Jacques J. Bergman, Carine Sondermeijer, Kausilia K. Krishnadath

5:15 #177

Esophageal Squamous Cell Cancer in a Transgenic Mouse Model of KLF4 Marie-Pier Tetreault*, Mei-Lun Wang, Bree G. Goldstein, Yizeng Yang, Qian-Chun Yu, Andres J. Klein-Szanto, Anil K. Rustgi, Jonathan P. Katz

AGA Institute Research Forum 4:00 PM - 5:30 PM

Chairs: Douglas A. Drossman, G. Richard Locke Sponsored by: Neurogastroenterology and Motility

FUNCTIONAL GI DISORDERS: EPIDEMIOLOGY AND SYMPTOMS Participants will be able to: • Learn about the role of war trauma on IBS prevalence. 4:00 #178

The Yield of Colonoscopy in Patients with NonConstipated Irritable Bowel Syndrome (IBS): Results from a Prospective, Controlled US Trial Borko Nojkov*, Joel H. Rubenstein, Brooks D. Cash, Richard J. Saad, Dong Lee, Richard R. Dobhan, Allan H. Andrews, William D. Chey

4:15 #179

Clinical Characteristics of Familial Irritable Bowel Syndrome (IBS) Differ from Sporadic IBS Yuri A. Saito*, Janice Zimmerman, Ann E. Almazar Elder, Joseph J. Larson, Elizabeth J. Atkinson, Brooke L. Fridley, Mariza de Andrade, G. Richard Locke, Gloria M. Petersen, Nicholas J. Talley

4:30 #180

Different Time Course of PDS Versus EPS Functional Dyspepsia Symptoms After Ingestion of a Meal Jan F. Tack*, Raf Bisschops, Joris Arts, Philip Caenepeel, Jozef Janssens

4:45 #181

Striking Prevalence of Irritable Bowel Syndrome in Former Prisoners of War: Analysis of Risk Factors Michele C. Pulling*, Mack Orsborn, Barbara J. Olson, Stephen Hunt, David J. Kearney

5:00 #182

Bowel Disorders in Gulf War Veterans Ashok K. Tuteja*, Keith G. Tolman, Nicholas J. Talley, Matthew Samore, Gregory J. Stoddard, Stacy Batt, G Nicholas Verne

8 San Diego Convention Center

Chairs: Rhonda F. Souza, Steven F. Moss Sponsored by: Gastrointestinal Oncology

ESOPHAGEAL NEOPLASMS AND BARRETT'S ESOPHAGUS: BIOLOGY, DIAGNOSIS AND TREATMENT Participants will be able to: • Evaluate the biology, diagnosis and treatment of esophageal neoplasms and Barrett's Esophagus. 4:00 #172

Novel Potential Markers of High Grade Dysplasia in Barrett's Esophagus Identified By cDNA Microarray Analysis of Laser Capture Microdissected Archival Tissue Edmond Sabo, Steven F. Moss*, Patricia Meitner, Rose Tavares, John Gao, Christopher Corless, Gregory Y. Lauwers, Murray B. Resnick

10 San Diego Convention Center

5:15 Sp272a

Overview Lecture: War Trauma and IBS Douglas A. Drossman

P-47

S U N D A Y MAY 18

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 4:00 PM - 5:30 PM

3 San Diego Convention Center

Chairs: Grigoris I. Leontiadis, Colin W. Howden

4:45 #191

Ubiquitination and Degradation of a Novel Tumor Suppressor Phlpp in Colon Cancer Cells Xin Li*, Tianyan Gao

5:00 #192

Notch Signaling Regulates Expression of the KrüppelLike Factor 4 Gene in the Intestinal Epithelium Amr Ghaleb*, Gaurav Aggarwal, Agnieszka Bialkowska, Mandayam O. Nandan, Vincent W. Yang

5:15 #193

KLF4 Differentially Regulates Histone Acetylation in Colon Cancer Cells Paul M. Evans*, Wen Zhang, Xi Chen, Jun Yang, Kishor K. Bhakat, Chunming Liu

Sponsored by: Esophageal, Gastric & Duodenal Disorders

NON-VARICEAL UGI BLEEDING: PHARMACOLOGICAL TREATMENT AND PROGNOSIS Participants will be able to: • Learn new developments in the area of non-variceal UGI bleeding.

S U N D A Y MAY 18

Prospective Randomized Comparison of the Effect of Oral PPI vs. Intravenous Bolus + Constant Infusion PPI On Intragastric pH in Patients with Bleeding Ulcers: Is Intermittent Oral PPI Therapy Sufficient? Abbid Shah*, Shahrooz Bemanian, Loren A. Laine

AGA Institute Topic Forum 4:00 PM - 5:30 PM

4:17 #185

Do Frequent Hemoglobin (Hgb) Checks Improve Outcomes in GI Hemorrhage? Sundip S. Karsan, Edward S. Huang, Inder M. Singh, Wayne Ho, Marc D. Makhani, Brennan M. Spiegel*

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease; Gastrointestinal Oncology

4:34 #186

Development and Validation of a Simple Risk Classification Rule for Patients with Acute Upper Gastrointestinal Bleeding Richard S. Johannes*, Ying P. Tabak, Xiaowu Sun, Anne T. Wolf, John R. Saltzman

4:51 #187

Systematic Review of the Epidemiology of Complicated Peptic Ulcer: Incidence, Recurrence, Risk Factors and Mortality James Y. Lau*, Joseph J. Sung, David C. Metz, Colin W. Howden

4:00 #184

5:08 Sp273

Chairs: Fernando S. Velayos, Daniel C. Baumgart

IMIBD ADVANCES IN IBD ASSOCIATED COLORECTAL CANCER AND DYSPLASIA. Participants will be able to: • Be familiar with the association of HLA class II genotype and the risk of ulcerative colitis-associated colorectal cancer; • Be familiar with the use of chromoendoscopy to screen for ulcerative colitis associated colorectal dysplasia; and • Be familiar with the impact of colonoscopy surveillance on survival of ulcerative colitis associated colorectal cancer. 4:00 #194

A Comprehensive Meta-Analysis of the Risk of Colorectal Cancer in Ulcerative Colitis and Crohn's Disease Maurice W. Lutgens*, Geert J. van der Heijden, Frank P. Vleggaar, Bas Oldenburg

4:15 #195

HLA Class II Genotype Predicts Increased Risk for Ulcerative Colitis-Associated Colorectal Cancer and Correlates with Methylation of the MHC Class II Transactivator (Ciita) Gene Megan Garrity-Park*, Edward V. Loftus, William J. Sandborn, Sandra C. Bryant, Thomas C. Smyrk

4:30 #196

Modeling Dysplasia Detection in Ulcerative Colitis: Clinical Implications of Surveillance Sensitivity Dahlia Awais*, Arashdeep K. Litt, Corey A. Siegel, Peter D. Higgins

4:45 #197

More Right-Sided IBD-Associated Colorectal Cancer in Patients with Primary Sclerosing Cholangitis Marian M. Claessen*, Maurice W. Lutgens, Henk R. van Buuren, Bas Oldenburg, Kristien Tytgat, Peter D. Siersema, Frank P. Vleggaar

5:00 #198

Follow-Up Chromoendoscopy Continues to Be Superior to Standard Colonoscopic Surveillance for Managing Dysplasia in Patients with IBD: A Long-Term, Prospective, Endoscopic Trial James F. Marion*, Jerome D. Waye, Daniel H. Present, Yuriy Israel, Carol A. Bodian, Noam Harpaz, Mark L. Chapman, Adam F. Steinlauf, Maria T. Abreu, Thomas A. Ullman, James Aisenberg, Steven H. Itzkowitz, Lloyd Mayer

5:15 #199

Colonoscopic Surveillance in Inflammatory Bowel Disease Improves Survival After Colorectal Cancer Diagnosis Maurice W. Lutgens*, Bas Oldenburg, Peter D. Siersema, Frank P. Vleggaar

Optimal pH Targets for Peptic Ulcer Bleeding David C. Metz

AGA Institute Research Forum 4:00 PM - 5:30 PM

26B San Diego Convention Center

Chairs: Mark R. Hellmich, Shrikant Anant Sponsored by: Gastrointestinal Oncology

RECEPTOR-MEDIATED SIGNALING EVENTS IN GASTROINTESTINAL CANCERS Participants will be able to: • Become familiar with receptor-mediated signaling events in gastrointestinal cancers. 4:00 #188

4:15 #189

4:30 #190

P-48

Activin Signaling in Microsatellite Stable (MSS) Colon Cancers Is Disrupted By a Combination of Genetic and Epigenetic Mechanisms Barbara H. Jung*, Jessica Gomez, Eddy Chau, Jennifer Cabral, Deena Ream-Robinson, Sung Kwan Shin, Ajay Goel, John M. Carethers EGFR Is Required for Tumor Promotion By Dietary Fat in a Murine Model of Inflammation-Associated Colon Cancer Urszula Dougherty*, Lata M. Aluri, Amikar Sehdev, Sonia R. Cerda, Reba Mustafi, Masha Kocherginsky, Ummuhan Tekin, Shamiram B. Badal, Sujatha Jagadeeswaran, Anusara Chumsangsri, Jorge-Shmuel Delgado, Loren Joseph, John Hart, David W. Threadgill, Alessandro Fichera, Marc Bissonnette Oncogenic K-RAS Regulates Expression of CCK2 Receptor Splice Variant in Human Colon Cancer Cells Bing Liu, Xiaodong Wen, Celia Chao, Courtney M. Townsend, Mark R. Hellmich*

24ABC San Diego Convention Center

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 4:00 PM - 5:30 PM

4 San Diego Convention Center

Chairs: Jonathan B. Meddings, Mark R. Frey Sponsored by: Intestinal Disorders; Hormones, Transmitters, Growth Factors, & Their Receptors

REGULATION OF INTESTINAL PERMEABILITY Participants will be able to: • Become familiar with the regulation of intestinal permeability. 4:00 #200

Molecular Mechanism of IL-1β-Induced Increase in CACO-2 Intestinal Epithelial Tight Junction Permeability Rana Al-Sadi*, Dongmei Ye, Thomas Y. Ma

4:15 #201

SRC Mediates Jun N-Terminal Kinase-Induced TyrPhosphorylation of Occludin During Tight Junction Disruption By Osmotic Stress and Dextran Sodium Sulfate Geetha Samak*, Ankur Seth, Radhakrishna (RK) Rao

4:30 #202

Expression of Active MEK1 Destabilizes Tight Junctions (TJs) in Undifferentiated Caco-2 Cells, While It Enhances TJ Integrity in Differentiated Cells Sudhir Aggarwal*, Takuya Suzuki, Ankur Seth, Radhakrishna (RK) Rao

4:45 #203

TAK1 Is Essential for Intestinal Epithelial Cell Survival and Regulates Intestinal Integrity Rie Kajino-Sakamoto*, Maiko Inagaki, Jae-Young Kim, Sylvie Robine, Kunihiro Matsumoto, Christian Jobin, Jun Ninomiya-Tsuji

5:00 #205

Mechanism of Interferon-Gamma Induced Increase in Intestinal Epithelial Tight Junction Permeability: Role of JNK Pathway and Cross-Talk with the PI-3 Kinase Pathway Praveen K. Roy*, Jing Chen, Farzana Rashid, Suzanne Ridenhour, Jamal A. Ibdah

5:15 #206

Effect of Chronic Oral Exposure to the Xenoestrogen Bisphenol a (BPA) On Epithelial Paracellular Permeability and Inflammatory Response in the Rat Colon Viorica Braniste*, Mathilde Leveque, Lionel Bueno, Jean Fioramonti, Eric Houdeau

S U N D A Y MAY 18

P-49

ORAL SESSIONS—SCIENTIFIC SESSIONS SCIENTIFIC SESSIONS ASGE Breakfast with Champions 6:30 AM - 8:00 AM

Sp274

AGA Institute Focused Research Roundtables 6:45 AM - 8:00 AM

Endoscopic Ultrasound (EUS): Outside the Envelope (BC01) Coronado (South Tower) Robert H. Hawes

Participants will be able to: • Review emerging research based on abstracts submitted to DDW 2008 focused on digestive disease, disorders and conditions.

Marriott Hotel & Marina Sp290

Sp275

ERCP: Cases and Controversies (BC02) Rancho Las Palmas (South Tower) Glen A. Lehman

Inflammation and Functional Bowel Disease (FR04) Ford B Robin C. Spiller

Manchester Hyatt

Marriott Hotel & Marina Sp291

Sp276

GI Bleeding: Endoscopic Control of Bleeding from the GI Tract (BC03) Torrance (South Tower) Dennis M. Jensen

Marriott Hotel & Marina Sp277

Polyps: The Endoscopist Owns Them All! (BC04) Mission Hills Jerome D. Waye

Pathogenesis of IBD (FR03) Stephan R. Targan

DDW Nurses Program 8:00 AM - 12:00 PM

Ford A Manchester Hyatt

4 San Diego Convention Center

Marriott Hotel & Marina Chairs: Malcolm S. Branch, Dariele Burchfield

AGA Institute Focused Clinical Updates 6:45 AM - 8:00 AM

DDW NURSES PROGRAM (PART I) 8:00

M O N D A Y

Participants will be able to: • Identify how state of the art and emerging research will impact management of digestive disease conditions; and • Review diagnostic and treatment options for patients with several digestive diseases. Sp282

MAY 19 Sp283

Sp284

Sp285

Capsule Endoscopy (FC12) Glenn M. Eisen Celiac Disease (FC08) Ciaran P. Kelly Clinical Trials in IBD (FC09) Remo Panaccione

Annie B Manchester Hyatt Moshen A Manchester Hyatt Moshen B Manchester Hyatt

Emerging Treatment Strategies for NAFLD (FC10) Stephen H. Caldwell Madeline A

Welcome and Introductions

8:05 Sp292

“The ABC's of EMR” Kevin M. McGrath, K. Jane Malick

9:00 Sp294

What Are the Threats to Endoscopy? David A. Johnson

9:50

Questions and Answers

10:00

Break

10:10 Sp295

“Performance Improvement Strategies for Operational Efficiency” Kevin Cooper, Dariele Burchfield

11:00 Sp297

Biliary and Pancreatic Imaging: What's New? Malcolm S. Branch, Elmar Merkle

11:50

Questions and Answers

AGA Institute Plenary Session 8:00 AM - 10:00 AM

Manchester Hyatt Sp286

Medical, Surgical and Endoscopic Therapy of Obesity (FC14) Lee M. Kaplan Madeline C

Manchester Hyatt Sp287

Neoplastic Pancreatic Cysts: Diagnosis and Management Update (FC15) Mohamad A. Eloubeidi Madeline D

Manchester Hyatt Sp288

Treatment of Functional GI Disorders (FC13) Anthony Lembo Madeline B

Manchester Hyatt Sp289

Update On Barrett's Esophagus and Esophageal Cancer (FC11) Kenneth K. Wang Annie A

Manchester Hyatt

P-50

29 San Diego Convention Center

Chair: Gail A. Hecht Sponsored by: AGA Institute

BASIC SCIENCE PLENARY Participants will be able to: • Become familiar with basic science in inflammatory bowel diseases and intestinal secretory mechanisms. 8:00 Sp299

Opening Remarks Gail Hecht

8:05 Sp301

Distinguished Mentor Award to Michael Field Nicholas F. LaRusso

8:15 #207

Prevention of DSS-Induced Colitis in Mice By a Probiotic-Derived Soluble Protein Fang Yan*, Hanwei Cao, M. Kay Washington, D. Brent Polk

ORAL SESSIONS—SCIENTIFIC SESSIONS 8:30 #208

Epigenetic Regulation of Foxp3+ Regulatory T Cells (Treg) By Small Molecule Targeting of a Single HDAC, HDAC6, Enhances Treg Function and Ameliorates Development of IBD in Murine Models Edwin F. deZoeten*, James E. Bradner, Ralph Mazitschek, Wayne W. Hancock

8:50 #214

Detection of Dysplasia in Barrett's Esophagus Using Narrow Band Imaging: Prospective, Controlled Tandem Endoscopy Study Dysplasia Detection in Patients with Barrett's Esophagus Herbert C. Wolfsen*, Sami R. Achem, Kenneth R. DeVault, Michael B. Wallace

8:45 Sp300

Overview Lecture: Novel Therapies in IBD - Small Molecules and New Strategies for Regulating Immune and Epithelial Cells in Intestinal Inflammation Peter B. Ernst

9:05 Sp304

Overview Lecture: Update On Diagnosis and Management of Dysplasia in Barrett's Esophagus Kenneth K. Wang

9:10 #209

Deletion of the Chloride Transporter Slc26a9 Causes Loss of Tubulovesicles in Gastric Parietal Cells and Impairs Acid Secretion Jie Xu, Jordi Ehrenfeld, Marian L. Miller, Zhaohui Wang, Sharon Barone, Seth Alper, Gary E. Shull, John G. Forte, Frank Borgese, Manoocher Soleimani*

9:30 Sp305

Distinguished Clinician Awards to Ronald J. Vender and Charles J. Lightdale and Distinguished Educator Award to Francis M. Giardiello Nicholas F. LaRusso

9:45 Sp306

Closing Remarks/Adjournment Reminder to Stay for Presidential Plenary Robert Sandler

9:25 #210

9:40 Sp302

Math1 Directs Intestinal Secretory Cell Specification and Is a Novel Regulator of Epithelium-Mesenchyme Signaling Kelli L. VanDussen*, Linda C. Samuelson Closing Remarks/Adjournment Gail A. Hecht

AGA Institute Plenary Session 8:00 AM - 10:00 AM

20BCD San Diego Convention Center

Chair: Robert S. Sandler Sponsored by: AGA Institute

CLINICAL SCIENCE PLENARY Participants will be able to: • Identify with new clinical research into colonoscopy and therapy of Barrett's Esophagus and short bowel syndrome.

ASGE Video Forum 8:00 AM - 12:00 PM

2008 ASGE ENDOSCOPIC VIDEO FORUM 8:00 Sp307

Introduction Kenneth R. McQuaid

Chairs: John A. Martin, Gregory B. Haber, Adam Slivka EUS/ERCP 8:05 Sp308 8:11 8:14 Sp309 8:22

8:00 Sp303

Opening Remarks Robert S. Sandler

8:05 #211

Does the First Colonoscopy of the Day Yield More Polyps Than Cases Performed Later? Michael Y. Chan, Hartley Cohen, Brennan M. Spiegel*

8:20 #212

Teduglutide, a Novel GLP-2 Analog, in the Management of Short Bowel Syndrome (SBS) Patients Dependent On Parenteral Nutrition: A Multicenter, Multinational Placebo-Controlled Clinical Trial Stephen J. O'Keefe*, Richard Gilroy, Palle B. Jeppesen, Bernard Messing, Johane P. Allard, Douglas L. Seidner, Marek Pertkiewicz, Roxanne Kapikian, Nancy McGraw, John Caminis

8:34 Sp311

A Randomized, Multicenter, Sham-Controlled Trial of Radiofrequency Ablation (RFA) for Subjects with Barrett's Esophagus (BE) Containing Dysplasia: Interim Results of the AIM Dysplasia Trial Nicholas J. Shaheen*, Prateek Sharma, Bergein F. Overholt, Charles J. Lightdale, Herbert C. Wolfsen, Richard E. Sampliner, Kenneth K. Wang, Mary P. Bronner, John R. Goldblum, Blair A. Jobe, Glenn M. Eisen, David E. Fleischer, Virender K. Sharma, Brenda Hoffman, Richard I. Rothstein, Hiroshi Mashimo, Kenneth J. Chang, V. Raman Muthusamy, Steven A. Edmundowicz, Stuart J. Spechler, Ali Siddiqui, Anthony Infantolino, Gary W. Falk, Michael B. Kimmey, Amitabh Chak

8:51

8:35 #213

6AB San Diego Convention Center

8:25 Sp310 8:31

8:42 8:45 Sp312

8:54 Sp313 9:00 9:03 Sp314 9:09

Endoscopic Transgastric Pancreatic Necrosectomy Nilay N. Mehta Q&A Endoscopic Transgastric Pancreatic Necrosectomy Using a Forward Viewing Echoendoscope Kenneth F. Binmoeller Q&A Endoscopic Stapled Cystgastrostomy David J. Desilets Q&A Biliary Recanalization Using a Magnetic Compression Device Takao Itoi Q&A Choledocho-Duodenostomy Using a Magnetic Compression Device Priya A. Jamidar Q&A Choledocho-Duodenstomy Using An EUS-Guided Compression Coil Kenneth J. Chang Q&A EUS-Guided Fiducial Placement for Treatment of Pancreatic Cancer with Stereotatic Radiosurgery David J. Owens Q&A

P-51

M O N D A Y MAY 19

ORAL SESSIONS—SCIENTIFIC SESSIONS Chairs: John A. Martin, Gregory B. Haber, Adam Slivka

Chairs: Ashley L. Faulx, Richard A. Kozarek, Todd H. Baron

NOTES

SMALL BOWEL/LOWER GI

9:12 Sp315 9:17 9:20 Sp316 9:28 9:31 Sp317

M O N D A Y MAY 19

Spectrum of Contemporary NOTES Gastrotomy Closures: How We Do It Mitsuhiro Asakuma Q&A Natural Orifice Endoscopic Transgastric Distal Pancreatectomy Field F. Willingham Q&A

11:06 Sp327

Endoscopic Management of a “Windsock” Diverticulum Rajesh N. Keswani

11:11

Q&A

11:14 Sp328

Endoscopic Therapy of Afferent Loop Syndrome Nonthalee Pausawasdi

11:19

Q&A

11:22 Sp329

Successful Treatment of a Completely Obstructed Anastomotic Stricture Using a Prototype Forwarding Viewing Echoendoscope Mark Anthony A. De Lusong

Human NOTES Transgastric Cholecystectomy Michael Ujiki

9:39

Q&A

11:27

Q&A

9:42

Presentation of ASGE Audiovisual Award, Presented by Grace H. Elta, MD, FASGE, ASGE President

11:30 Sp330

Award Winner: Image Enhanced Endoscopy Roy M. Soetikno

Endoscopic Closure of Colonic Perforations After EMR or ESD for Early Colon Cancer Yutaka Saito

11:38

Q&A

Award Recipient: Endoscopic Papillectomy for Tumors of the Major Duodenal Papilla Tae Yoon Lee

11:41 Sp331

Endoscopic Submucosal Dissection Using a Ball-Tip Bipolar Needle Knife for Large Colorectal Tumors Yutaka Saito

Award Recipient: Endoscopic Treatments of Early Esophageal Cancer and Early Neoplasia in Barrett's Esophagus Tae Hee Lee

11:48

Q&A

11:51 Sp332

Colonoscopic Full-Thickness Resection Before Endoluminal Colon Surgery Gottumukkala S. Raju

11:57

Q&A

12:00

Conclude

9:50

Break

Chairs: Ashley L. Faulx, Richard A. Kozarek, Todd H. Baron UPPER GI 10:10 Sp321

ESD for Circumferential Barrett's Esophageal Cancer Tsuneo Oyama

10:16

Q&A

10:19 Sp322

Esophageal En Bloc Mucosectomy Field F. Willingham

10:27

Q&A

10:30 Sp323

The Cutting Edge of Endoscopic Dissection Marvin Ryou

10:36

Q&A

10:39 Sp324

Endoscopic Submucosal Dissection of Early Gastric Cancer Using Magnetic Anchor Shinsuke Kiriyama

10:45

Q&A

10:48 Sp325

Treatment of Weight Regain Following Gastric Bypass Surgery: Endoscopic Techniques for Revision of the Gastrojejunal Anastamosis and Gastric Pouch Daniel K. Mullady

10:54

Q&A

10:57 Sp326

Removal of Foreign Body Material from the Bariatric Patient: A Unique Challenge for the Gastroenterologist Daniel K. Mullady

11:03

Q&A

P-52

SSAT Special Session 8:00 AM - 8:15 AM

25 San Diego Convention Center

Chair: John C. Bowen SSAT OPENING SESSION SSAT Plenary Session 8:15 AM - 9:15 AM

25 San Diego Convention Center

Chair: Richard A. Prinz SSAT PRESIDENTIAL PLENARY A (PLENARY SESSION I) Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 8:15 #215

Stepwise Circumferential and Focal Radiofrequency Ablation of Barrett's Esophagus with High-Grade Dysplasia or Intramucosal Cancer Roos E. Pouw, Joep J. Gondrie, Frederike G. Van Vilsteren, Carine Sondermeijer, Wilda Rosmolen, Wouter L. Curvers, Lorenza Alvarez Herrero, Fiebo J. ten Kate, Kausilia K. Krishnadath, Thomas M. Van Gulik, Paul Fockens, Bas L. Weusten, Jacques J. Bergman*

ORAL SESSIONS—SCIENTIFIC SESSIONS 8:30 #216

Long-Term Results of Transanal Excision After Neoadjuvant Chemoradiation for t2 and T3 Adenocarcinomas of the Rectum Rajesh Nair*, Erin M. Siegel, Timothy J. Yeatman, Mokenge P. Malafa, Jorge Marcet, David Shibata

8:45 #217

High Volume Surgery and Outcome After Liver Resection: Surgeon or Center? Robert W. Eppsteiner, Nicholas Csikesz, Jennifer F. Tseng, Shimul A. Shah*

9:00 #218

Laparoscopic Vertical Sleeve Gastrectomy for Morbid Obesity: A Report of a Five-Year Experience with 750 Patients Crystine M. Lee, Paul T. Cirangle, Gregg H. Jossart*

ASGE Clinical Symposium 8:30 AM - 10:00 AM

5 San Diego Convention Center

8:45 #220

Innate Immune Responses in Murine Parenchymal and Non-Parenchymal Liver Cells Are Suppressed By the Hepatitis B Virus Jun Wu, Mengji Lu, Joerg F. Schlaak*

9:00 #221

Interferon Regulated Gene Expression in the Liver Determines Response to Treatment in Chronic Hepatitis C Magdalena Sarasin-Filipowicz*, Verena Christen, Francois H. Duong, Edward Oakeley, Luigi Terracciano, Witold Filipowicz, Markus H. Heim

9:15 #222

Serial Monitoring of Viral Load and Serum Alanine Aminotranferase Level and the Risk of Hepatocellular Carcinoma: R.E.V.E.a.L.-HBV Study Update Chien-Jen Chen*, Hwai-I Yang, Jun Su, Chin-Lan Jen, SanLin You, Chuen-Fei Chen, Uchenna H. Iloeje

9:30 #223

Prove1: Results from a Phase 2 Study of Telaprevir with Peginterferon Alfa-2a and Ribavirin in Treatment-Naive Subjects with Hepatitis C Gregory T. Everson*, Ira M. Jacobson, Stuart C. Gordon, John G. McHutchison, Robert Kaufman, Lindsay McNair, Andrew Muir

9:45 #224

COX-2 Deficiency Modulates TH1/Th2 Cytokine Balance and Impairs Macrophage Activation in Hepatic Ischemia/ Reperfusion Injury Takashi Hamada*, Sergio Duarte, Ana J. Coito

Chairs: James M. Scheiman, David J. Bjorkman ANTIBIOTICS, ANTIPLATELETS, ANTICOAGULANTS AND ENDOSCOPY 8:30 Sp333

Evidence Based Use of Antibiotics in Endoscopic Practice Subhas Banarjee

8:50 Sp334

Anticoagulants and Antiplatelets - Rationale for Appropriate Therapy James M. Scheiman

AASLD Topic Forum 8:30 AM - 10:00 AM

9:10 Sp335

A Practical Approach and Medicolegal Implications John L. Petrini

Chairs: J Eileen Hay, Jonathan M. Schwartz

Questions & Answers

ACUTE LIVER FAILURE

9:30

ASGE Clinical Symposium 8:30 AM - 10:00 AM

6C San Diego Convention Center

Chairs: William M. Tierney, Karen L. Woods

8:30 #225

Quality Colonoscopy: Technical Aspects and Optimal Post-Polypectomy Follow-Up Intervals David A. Lieberman

8:50 Sp335b

The Difficult Polyp: Polypectomy Do's and Don'ts Douglas K. Rex

9:10 Sp335c

Polypectomy Complications: Optimal Management Strategies Jerome D. Waye

9:30

Role of Human-Hepatocyte Growth Factor (Hgf) Serum Levels, Gene Expression in Hepatic Tissue and Blood, in Determining the Clinical Outcome in Patients of Fulminant Hepatic Failure(Fhf) montish singla*, Subhash Medhi, Premashis Kar

9:00 #227

Racial and Ethnic Differences in Presentation, Etiology and Outcomes Following Acute Liver Failure in the United States Kimberly A. Forde*, K. Rajender Reddy, Andrea B. Troxel, Corron M. Sanders, William M. Lee

9:15 #228

Extent of Recovery of Neurocognitive Dysfunction in Patients Presenting with Severe Hepatic Encephalopathy Tarek Hassanein*, Deanna Oliver, Fatma Barakat, Meghan Carlson, Jan Stange, Elliot Alpert, Khaled Selim, William Perry

9:30 #229

A Prospective Study of Acute Liver Failure Due to Hepatic Ischemia: Clinical Features and Outcomes Kartikkumar Jinjuvadia*, Ryan M. Taylor, Robert J. Fontana, Timothy J. Davern, Obaid S. Shaikh, Steven-Huy B. Han, Raymond T. Chung, William M. Lee

9:45 #230

Huge-Volume Buffer of Artificial Liver Support Removes Significant Glutamine from Patient Plasma Associated with Good Clinical Effects Kazuaki Inoue*, Makoto Yoshiba

Questions & Answers

AASLD Plenary Session 8:30 AM - 10:00 AM

6DE San Diego Convention Center

Chairs: Arun J. Sanyal, Arthur J. McCullough PRESIDENTIAL PLENARY II 8:30 #219

Interaction of Collagen mRNAs with Nonmuscle Myosin Filaments in Hepatic Stellate Cells Is Required for High Level of Collagen Synthesis Dillon Fritz, Le Cai, Lela Stefanovic, Branko Stefanovic*

An Aers Database Evaluation of the Influence of CoMedications On Acetaminophen-Associated Liver Injury Ayako Suzuki*, Nancy A. Yuen, Julie I. Papay, John S. Walsh, Christine M. Hunt, Anna Mae Diehl

8:45 #226

POLYPECTOMY: ISSUES AND ANSWERS 8:30 Sp335a

7B San Diego Convention Center

P-53

M O N D A Y MAY 19

ORAL SESSIONS—SCIENTIFIC SESSIONS ASGE Topic Forum 8:30 AM - 10:00 AM

11 San Diego Convention Center

8:40 #238

Improving the Quality of Colonoscopy in Term of Visibility By Adding Simethicone to Sodium Phosphate for Bowel Preparation Sasinee Tongprasert*, Abhasnee Sobhonslidsuk, Panida Thong-Uthaisri, Narin Achalanan, Chutima Pramoolsinsap, Chomsri Kositchaiwat, Sasivimol Rattanasiri

8:50 #239

Accrediting Competence in Colonoscopy: Validity and Reliability of the UK Joint Advisory Group/NHS Bowel Cancer Screening Programme Accreditation Assessment Roger Barton

9:00 #240

Evaluation of Patient Pain During Colonoscopy for Types of Looping Between Hood Attached Group and Non-Hood Attached Group: An Analysis Using Magnetic Endoscope Imaging (MEI) Koichiro Sato*, Koichi Hirahata, Sumio Fujinuma, Tadayoshi Kakemura, Iruru Maetani

9:10 #241

Colonoscopy in the Elderly: Worse Preparation, Better Tolerability Kinesh P. Patel*, Jocelyn L. Aldridge, Kuldeep Cheent, Gautam Mehta, Neil P. Patel, Nisha Patel, Devinder S. Bansi, Andrew V. Thillainayagam

9:20 #242

Treatment of Acute Ulcer Bleeding in the Upper Gastrointestinal Tract with Fibrin Adhesion Deniz Uyak

9:30 #242a

Changing Colonoscopy Performance to Meet the Quality Indicator of Withdrawal Time: Results of a Clinic-Based Improvement Intervention Kirsten T. Weiser*, Lynn F. Butterly, Arifa Toor, Karen Homa, Maren E. Flynn, Peter B. Anderson, Paul B. Batalden

9:40 Sp337

State-of-the-Art Lecture: Screening High-Risk Minorities Robynne K. Chutkan

Chairs: Richard E. Sampliner, Reza Shaker BARRETT'S ESOPHAGUS: DETECTION, MANAGEMENT, AND FOLLOW-UP 8:30 #231

8:42 #232

M O N D A Y MAY 19

Prospective Multicenter Study On the Incidence of Neoplastic Progression in Barrett Esophagus Patients Marjolein Sikkema*, Marjon Kerkhof, E. W. Steyerberg, Herman van Dekken, Anneke van Vuuren, Willem A. Bode, Hans van der Valk, Dirk Jan Bac, Raimond Giard, Wilco Lesterhuis, Robert Heinhuis, Elly C. Klinkenberg, Gerrit A. Meijer, Frank T. Borg, Jan-Willem Arends, Jeroen J. Kolkman, Joop van Baarlen, Richard A. de Vries, Andries H. Mulder, Antonie J. Van Tilburg, Johan Offerhaus, Fiebo J. ten Kate, Johannes G. Kusters, E. J. Kuipers, Peter D. Siersema A Randomized Prospective Trial Comparing the CapTechnique and Multi-Band Mucosectomy Technique for Piecemeal Endoscopic Resection in Barrett's Esophagus Roos E. Pouw*, Joep J. Gondrie, Lorenza Alvarez Herrero, Frederike G. Van Vilsteren, Femke Peters, Wilda Rosmolen, Fiebo J. ten Kate, Kausilia K. Krishnadath, Paul Fockens, Bas L. Weusten, Jacques J. Bergman

8:54 #233

Study of Preoperative and Postoperative Pathology in High Grade Barrett's Dysplasia John Y. Nasr*, Luketich James, Robert E. Schoen

9:06 #234

Are Patients with “Low Risk” Submucosal Invasion of Early Barrett's Carcinoma Eligible for Curative Endoscopic Therapy? Outcomes of Endoscopic Therapy and Surgery in 80 Patients with Suspected or Definite Diagnosis of Submucosal Barrett's Cancer Hendrik Manner*, Andrea May, Oliver Pech, Liebwin Gossner, Thomas Rabenstein, Michael Vieth, Christian Ell

9:18 #235

9:30 #236

9:42 Sp336

Endoscopic Cryotherapy Ablation Is Safe and WellTolerated in Barrett's Esophagus, Esophageal Dysplasia, and Esophageal Cancer Bruce D. Greenwald*, J. David Horwhat, Julian A. Abrams, Charles J. Lightdale, John A. Dumot Low Rate of Invasive Cancer in Patients Undergoing Mucosectomy for Barrett's Esophagus (BE) and High Grade Dysplasia (HGD) or Intramucosal Carcinoma (IMC) Vani J. Konda*, Jennifer S. Chennat, Andrew S. Ross, Shang P. Lin, Barbara M. Cislo, Lynne Stearns, Amy E. Noffsinger, John Hart, Mitchell C. Posner, Mark K. Ferguson, Irving Waxman State-of-the-Art Lecture: Barrett's Esophagus: Who Is At Risk and Who Needs Ablation Richard E. Sampliner

ASGE Topic Forum 8:30 AM - 10:00 AM

1 San Diego Convention Center

ASGE Topic Forum 8:30 AM - 10:00 AM

Chairs: Chris A. Liacouras, Victor L. Fox PEDIATRIC ENDOSCOPY 8:30 #243

Per-Oral Suturing As a Potential Treatment for Adolescent Obesity - A Pilot Investigation of 12 Patients with 6-Months Follow-Up Roberto Fogel*, Juana F. De Fogel

8:42 #244

Ketamine Versus Midazolam/Fentanyl Sedation for Pediatric Endoscopy: Comparison of Patient Movement, Need for Restraint and Vocalization of Distress Jenifer R. Lightdale*, Meghan E. Fredette, Paul D. Mitchell, Erik A. Reilly, Lisa B. Mahoney, Steven E. Zgleszewski, Victor L. Fox

8:54 #245

Esophageal Polyps in Pediatric Patients Undergoing Upper Gastrointestinal Endoscopy Seth S. Septer*, Carmen Cuffari, Christine Reyes, Neil J. Rawlinson, Thomas Attard

9:06 #246

Wireless Capsule Retention in Pediatric Patients - What We Have Learned Orhan K. Atay*, Franziska Mohr, Lori Mahajan, Barbara Kaplan, Marsha H. Kay, Robert Wyllie

9:18 #247

Impact On Management of Small Intestinal Disorders By Wireless Capsule Endoscopy in Young Children Less Than Age 8: A European Multicenter Study Annette Fritscher-Ravens*, Peter L. Shcherbakov, Philip Bufler, Kaija-Leena Kolho, Mike Thomson, Filippo Torroni, Tarja Ruuska, Merit Tabbers, Peter Milla

Chairs: Douglas O. Faigel, Douglas B. Nelson IMPROVING THE QUALITY OF YOUR COLONOSCOPY PRACTICE: HOW CAN WE DO IT BETTER? 8:30 #237

P-54

Duration of the Interval Between Completion of the Bowel Preparation and Start of the Colonoscopy As a Better Predictor of Bowel Preparation Quality Than Colonoscopy Start Time Alone Kenneth Yang*, Ali Siddiqui, Stuart J. Spechler, Byron L. Cryer, Raquel E. Davila, William Harford

2 San Diego Convention Center

ORAL SESSIONS—SCIENTIFIC SESSIONS 9:30 #248

Evaluation Study On the Correlation Between Optical Coherence Tomography and Histology in the Diagnosis of Celiac Disease in Pediatric Patients Benedetto Mangiavillano*, Enzo Masci, Luca Albarello, Claudio Doglioni, Barbara Parma, Graziano Barera, Testoni Pier Alberto

SSAT Plenary Session 10:30 AM - 11:15 AM

9:42 Sp338

State-of-the-Art Lecture: Diagnostic Approach to Small Bowel Disease in Children David R. Cave

SSAT PRESIDENTIAL PLENARY B (PLENARY SESSION II)

SSAT Address/Oration/Lecture 9:15 AM - 10:00 AM

25 San Diego Convention Center

SSAT PRESIDENTIAL ADDRESS 9:15 Sp339

Introduction Richard A. Prinz

9:20 Sp340

Evolution of a Surgeon: A 40-Year Perspective John C. Bowen

AGA Institute Plenary Session 10:00 AM - 11:25 AM

20BCD San Diego Convention Center

Chairs: Nicholas F. LaRusso, Damian H. Augustyn Sponsored by: AGA Institute

Chair: John C. Bowen

Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 10:30 #249

Role of Prophylactic Antibiotics in Laparoscopic Cholecystectomy: A Meta-Analysis Abhishek Choudhary*, Matthew L. Bechtold, Craig Karpman, Srinivas R. Puli, Mohamed O. Othman, Praveen K. Roy

10:45 #250

Comparison of Surgically Resected Polypoid Lesions of the Gallbladder to Their Pre-Operative Ultrasound Characteristics Martin D. Zielinski*, Peyton W. Davis, Florencia G. Que, Michael L. Kendrick, Thomas D. Atwell

11:00 #251

The Incidental Asymptomatic Pancreatic Lesion: Nuisance or Threat? Teviah E. Sachs*, Wande B. Pratt, Mark P. Callery, Charles M. Vollmer

2008 PRESIDENTIAL PLENARY 10:00 Sp341

Opening Remarks Damian H. Augustyn

10:02 Sp342

Presentation of the Distinguished Achievement Award to John G. Forte, Followed By Lecture Nicholas F. LaRusso

10:17 Sp343

Gastroenterology: The Year in Review Anil K. Rustgi

10:37 Sp344

Clinical Gastroenterology & Hepatology: The Year in Review C. Mel Wilcox

10:57 Sp345

Presentation of Friedenwald Medal to Martin Brotman Nicholas F. LaRusso ST

11:02 Sp346

The AGA in the 21 Century: A Professional Society with a Social Conscience Nicholas F. LaRusso

11:12 Sp347

AGA-AGA Institute Financial and Membership Report Damian H. Augustyn

11:15 Sp347a

Report of the Nominating Committee and Introduction of the Incoming President Damian H. Augustyn

11:20 Sp347b

Adjournment Damian H. Augustyn

25 San Diego Convention Center

AASLD State-of-the-Art-Lecture 10:30 AM - 11:30 AM

6DE San Diego Convention Center

MAY 19

Chair: Arun J. Sanyal NAFLD: DOES IT NEED TO BE TREATED? Participants will be able to: • Review epidemiologic impact of NAFLD; • Describe clinical assessment of patients with NAFLD; and • Review current drug options. 10:30 Sp348

NAFLD: Does It Need to Be Treated? Zobair M. Younossi

AASLD Clinical Symposium 10:30 AM - 12:00 PM

7B San Diego Convention Center

Chairs: Vincent G. Bain, Eberhard L. Renner EXTRACORPOREAL ALBUMIN DIALYSIS FOR LIVER FAILURE Participants will be able to: • Gain an appreciation for the scientific rationale for the use of extracorporeal albumin dialysis in liver failure; • Be familiar with clinical experience with albumin dialysis and understand its limitations; and • Appreciate the potential of albumin dialysis for future clinical care. 10:30 Sp349

M O N D A Y

Rationale and Devices: Introduction to the Different Systems/Mechanisms of Action/Pathophysiologic Effects in Man Steffen Mitzner

P-55

ORAL SESSIONS—SCIENTIFIC SESSIONS 10:50 Sp350

Clinical Efficacy and Safety: Critical Review of Clinical Data Available Dean Karvellas

11:10 Sp351

Future Development: Discussion of Optimal Outcome Measures for Future Trials George Therapondos

11:30

Discussion

ASGE Clinical Symposium 10:30 AM - 12:00 PM

1 San Diego Convention Center

11:30 #256

Peginterferon Alpha-2a Plus Adefovir Dipivoxil vs. Peginterferon Alpha-2a Monotherapy for 48 Weeks in HBeAg-Negative Chronic Hepatitis B: Final Results of the PEG for B Randomized Multicenter Trial Paola Piccolo*, Luigi De Melia, Franco Bandiera, Maria Rosaria Piras, Giorgio Antonucci, Lorenzo Nosotti, Terenzio Mari, Adriano De santis, Laura Ponti, Ilaria Lenci, Daniele Di Paolo, Claudia Telesca, Orazio Sorbello, Fabio Iacomi, Francesca Cristofari, Mario Angelico

11:45 #257

Treatment Recommendations for Chronic Hepatitis B: An Evaluation of Current Guidelines Based On a Natural History Study in the United States Myron J. Tong*, Carlos Hsien, Leeyen Hsu, Lawrence M. Blatt

Chairs: James J. Farrell, William R. Brugge MOLECULAR MEDICINE AND THE ENDOSCOPIST

M O N D A Y MAY 19

ASGE Topic Forum 10:30 AM - 12:00 PM

11 San Diego Convention Center

10:30 Sp352

Molecular-Based Imaging of GI Malignancy Umar Mahmood

10:45 Sp353

Is There a Role for Molecular Markers in the Diagnosis of Pancreaticobiliary Diseases? Asif Khalid

11:00 Sp354

How I Use Molecular Markers in the Endoscopic Evaluation of the Indeterminate Biliary Stricture Laura Moreno

10:30 #258

Quality Polyp Resection in Colonoscopy: Are We Achieving Polyp Clearance? Samuel B. Ho, Mary L. Krinsky*

11:15 Sp355

The Future of Endoscopic Molecular Markers in the Evaluation and Diagnosis of Pancreaticobiliary Diseases Michael G. Goggins

10:42 #259

11:30

Case Presentation and Discussion

Clinical and Economic Impacts of a Tertiary Referral Colonoscopic Polypectomy Service (TRCPS) Sina Alexander, Michael J. Bourke*, Stephen J. Williams, Jonard Co, Adam A. Bailey, Venessa Pattullo, Animesh Mishra

10:54 #260

Mandated Screening of All Veterans for Colorectal Cancer: The FOBT Versus the C-Scope Mariam Sauer*, Stephen J. Sontag, Thomas G. Schnell, Jack Leya

11:06 #261

Colonoscopy Withdrawal Time and Risk of Neoplasia On Follow-Up Colonoscopy: Results from VA Cooperative Study Program 380 Ziad F. Gellad*, David G. Weiss, Dennis Ahnen, David A. Lieberman, George L. Jackson, Dawn Provenzale

11:18 #262

Simply Recording Colonoscopy Withdrawal Time Increases Polyp Detection Rate Andrew Taber*, Joseph Romagnuolo

11:30 #263

The Effect of Periodic Monitoring On Screening Colonoscopy Withdrawal Times, Polyp Detection Rates and Patient Satisfaction Scores Otto Lin*, Richard A. Kozarek

11:42 Sp356

State-of-the-Art Lecture: Improving Colonoscopy Outcomes Jason A. Dominitz

AASLD Topic Forum 10:30 AM - 12:00 PM

Chairs: Andrew W. DuPont, Cynthia W. Ko COLONOSCOPIC SCREENING AND POLYPECTOMY

6F San Diego Convention Center

Chairs: Norah Terrault, TBD HBV: FROM PATHOGENESIS TO TREATMENT 10:30 #252

High Maternal Hepatitis B Virus DNA Levels But Not HBeAg Positivity Predicts Perinatal Transmission of Hepatitis B to the Newborn Chandana Pande*, Ashish Kumar, Sharda Patra, Shubha S. Trivedi, Ashok K. Dutta, Shiv Kumar Sarin

10:45 #253

The Proportions of Hepatitis B Virus Splice Variants Significantly Increased Before Hbe-Seroconversion and After Treatment with Lamivudine Guan-Huei Lee*, Masafumi Inoue, Shanthi Wasser, Aung Myat Oo, Seng Gee Lim

11:00 #254

Tenofovir Disoproxil Fumarate (TDF) for the Treatment of HBeAg-Positive Chronic Hepatitis B: Week 72 TDF Data and Week 24 Adefovir Dipivoxil Switch Data (Study 103) Jenny Heathcote*, Jacob George, Stuart C. Gordon, JeanPierre Bronowicki, Jan Sperl, Roger Williams, Paul Martin, Vinod K. Rustgi, Jeff Sorbel, Jane Anderson, Elsa Mondou, Andrea Snow-Lampart, Franck Rousseau

11:15 #255

P-56

Chronic Hepatitis B Genotype B or C E Antigen Positive Patients: Viral Suppression, HBeAg Loss and Seroconversion Rates Are Improved with Telbivudine Compared with Lamivudine - Results from a Pooled Analysis Christopher B. O'Brien*, Jidong Jia, Gillian Zeldin

ASGE Topic Forum 10:30 AM - 12:00 PM

6C San Diego Convention Center

Chairs: Lauren B. Gerson, Banke Agarwal UPPER GI BLEEDING: CURRENT THERAPEUTIC TRENDS 10:30 #264

For Severe UGI Hemorrhage Doppler Ultrasound Probe Is More Accurate for Risk Stratification and Helpful for Complete Endoscopic Hemostasis Than Lesion Stigmata Alone Dennis M. Jensen*, Gordon V. Ohning, Bhavneet Singh, Thomas O. Kovacs, Rome Jutabha, Gustavo A. Machicado

ORAL SESSIONS—SCIENTIFIC SESSIONS 10:42 #265

Initial Evaluation of a Novel Prototype Forward-Viewing Echoendoscope in a Porcine Arterial Bleeding Model Michael J. Pollack*, B. Joseph Elmunzer, Joseph A. Trunzo, Michael F. McGee, Jeffrey L. Ponsky, Jeffrey M. Marks, Richard C. Wong, Steve J. Schomisch, Amitabh Chak

10:54 #266

Prokinetic Agent- Metoclopromide Increases the Yield of Upper Endoscopy and Decreases the Need for Second Look Endoscopy in Patients with Upper Gastrointestinal Bleed a Randomized Prospective Study Renuka Gupta*, Niket Sonpal, Netrali Patel, Vijay Arya

11:06 #267

Does Endoscopic Therapy of Bleeding Peptic Ulcers Influence Need for Repeat Endoscopy? Brintha K. Enestvedt*, Ian M. Gralnek, Nora Mattek, David A. Lieberman, Glenn M. Eisen

11:18 #268

11:30 Sp357

A Method for Endoscopic Obturation of Gastric Varices That Maximizes Effectiveness Without Risks of Systemic Embolization Bimaljit S. Sandhu*, Andres D. Mogollon, Richard T. Stravitz, Richard K. Sterling, Velimir A. Luketic, Mitchell L. Shiffman, Doumit BouHaidar, Michael Fuchs, Arun J. Sanyal State-of-the-Art Lecture: Evidence-based Management of Acute Upper GI Bleeding Thomas F. Imperiale

ASGE Topic Forum 10:30 AM - 12:00 PM

5 San Diego Convention Center

SSAT Address/Oration/Lecture 11:15 AM - 12:00 PM

25 San Diego Convention Center

SSAT DORIS AND JOHN L. CAMERON GUEST ORATION 11:15 Sp359

The Coming American Revolution: How China Will Cause the Greatest Changes in the U.S. Since the Birth of the Nation Louis M. Bowen

ASGE Interactive Education 12:00 PM - 2:00 PM

Marina Ballroom, Salon G Marriott Hotel & Marina

Chairs: Kenneth K. Wang, Virender K. Sharma ADVANCES IN ESOPHAGEAL THERAPIES AND BEYOND (IE01) 12:00 Sp360

Advances in Esophageal Therapies and Beyond Jacques J. Bergman, Ananya Das, Bruce D. Greenwald, Ralf Kiesslich, Richard I. Rothstein, George Triadafilopoulos, Herbert C. Wolfsen

ASGE Interactive Education 12:00 PM - 2:00 PM

Marriott Hall, Salon 2 Marriott Hotel & Marina

Chairs: Oleh Haluszka, Dayna S. Early

Chairs: Robynne K. Chutkan, Christopher J. Gostout

WHAT'S NEW IN LOWER GI BLEEDING AND POLYPS

CAPSULE ENDOSCOPY (IE02)

10:30 #269

10:42 #270

10:54 #271

The Effect of Radiotherapy for Prostate Cancer On Later Rectal Injury Terry Bolin*, Andrew B. Kneebone, Martin P. Berry, Sandra Turner

WITHDRAWN

Clinical Significance of Incidental 18F-FDG Uptake in the Colon On PET/CT: Colonoscopic Findings in a Case Control Study Brian R. Weston*, Revathy B. Iyer, Jeffrey H. Lee, William A. Ross Development and Validation of a Simple Risk Classification Rule for Patients with Acute Lower Gastrointestinal Bleeding Richard S. Johannes*, Ying P. Tabak, Xiaowu Sun, Anne T. Wolf, John R. Saltzman

11:06 #272

Family History of Single First-Degree Relative with Colorectal Cancer Does Not Predict Increased Risk of Advanced Adenomas On Screening Colonoscopy in a Southwestern U.S. Population Franklin Tsai*, Williamson Strum

11:18 #273

Treatment Strategy for Laterally Spreading Tumors: Historical Overview Since the Introduction of Colorectal Endoscopic Submucosal Dissection Nozomu Kobayashi*, Yutaka Saito, Toshio Uraoka, Haruhisa Suzuki, Takahisa Matsuda

11:30 #274

Prospective Study and Description of the Suction Pseudo-Polyp Technique for the Removal of Small Flat Polyps of the Colon and Rectum Venessa Pattullo*, Michael J. Bourke, Stephen J. Williams, Adam A. Bailey, Sina Alexander, Animesh Mishra, Jonard Co

11:42 Sp358

State-of-the-Art Lecture: Evolving Colonoscopic Therapy Roy M. Soetikno

12:00 Sp361

M O N D A Y

Capsule Endoscopy (IE02) Robynne K. Chutkan, Christopher J. Gostout

MAY 19

ASGE Poster Grand Rounds 12:15 PM - 1:00 PM

Sp362

Sp363

Colonoscopy Philip S. Schoenfeld Small Bowel Imaging Carol E. Semrad

5 San Diego Convention Center 6C San Diego Convention Center

DDW Meet-the-Investigator Luncheons 12:30 PM - 1:45 PM

Participants will be able to: • Identify new scientific and clinical information relevant to digestive diseases; • Engage in scholarly and dynamic discussions of specific clinical topics; and • Engage in scholarly and dynamic discussions of specific investigative topics. Sp364

Advances in NASH (M01) Newport Beach (South Tower) Jacquelyn J. Maher

Marriott Hotel & Marina Sp365

Molecular Biology of GI Cancer (M03) John P. Lynch

Warner Center Marriott Hotel & Marina

P-57

ORAL SESSIONS—SCIENTIFIC SESSIONS Sp366

Stems Cells in the Gastrointestinal Tract (M02) Madeline A Susan J. Henning

Sp380

Esophageal Physiologic Testing in 2008 (M13) Emma B Peter J. Kahrilas

Manchester Hyatt

Manchester Hyatt Sp381

DDW Meet-the-Professor Luncheons 12:30 PM - 1:45 PM

31A San Diego Convention Center

Sp382 Participants will be able to: • Identify new scientific and clinical information relevant to digestive diseases; • Engage in scholarly and dynamic discussions of specific clinical topics; and • Engage in scholarly and dynamic discussions of specific investigative topics. Sp367

Sp383

Sp384

Advances in Biliary Endoscopy (M19) John A. Martin

33BC San Diego Convention Center

Sp368

Balancing Cardiovascular Risks with NSAID Use (M24) Maggie James M. Scheiman Capsule: Small Bowel and Beyond (M08) Sponsored by the ASGE Capsule Endoscopy/Small Bowel Endoscopy SIG Robert A. Enns, Klaus Mergener 30A

San Diego Convention Center

M O N D A Y MAY 19

Sp370

Sp371

Celiac Disease (M09) Alessio Fasano

Ford A Manchester Hyatt

Sp385

Sp386

Sp373

Sp374

Colorectal Cancer (M23) Thomas F. Imperiale

Sp387

Sp388

Sp375

Sp376

Downsizing Hepatocellular Carcinomas Prior to Liver Transplantation (M31) Francis Y. Yao, Alex Befeler Balboa (South Tower)

Marriott Hotel & Marina Sp377

Emerging Therapies for Functional GI Disorders (M05) Lin Chang Madeline C

Manchester Hyatt Sp378

Sp379

Endoscopy in IBD (M14) Ralf Kiesslich

33A San Diego Convention Center

Enteral Nutrition (M20) Sponsored by the ASGE Enternal Nutrition SIG Stephen A. McClave Greenroom (South Tower)

Marriott Hotel & Marina

P-58

Management of Cytopenias During HCV Therapy: Are EPO and GCSF Useful? (M28) Mark S. Sulkowski Pacific (South Tower) Management of Difficult Esophageal Strictures (M16) Sponsored by the ASGE ETED SIG Michael L. Kochman, Patrick R. Pfau 30C Preventing ERCP Complications (M11) Martin L. Freeman, Kapil Gupta Propofol and Sedation Issues (M29) John A. Walker

30E San Diego Convention Center

Annie B Manchester Hyatt

San Diego Convention Center

Local Therapy for Rectal Cancer (M26) Carlsbad (South Tower) Anthony Senagore

30B San Diego Convention Center

Sp390

Double-Balloon Enteroscopy (M25) Sponsored by the ASGE Small Bowel Endoscopy SIG Drew B. Schembre, Andrew S. Ross 30D

Living Donor Liver Transplantation (M22) John P. Roberts, Jean Botha Oceanside (South Tower)

San Diego Convention Center Sp389

San Diego Convention Center

Idiopathic Pancreatitis: Diagnosis and Management (M10) Chris Forsmark, Nalini M. Guda Ford B

Marriott Hotel & Marina

Del Mar (South Tower) Marriott Hotel & Marina

Correlating Histology with Enhanced Endoscopic Imaging (M27) Prateek Sharma, Wouter L. Curvers 31BC

Ford C Manchester Hyatt

Marriott Hotel & Marina

Chemoprevention and GI Cancer (M04) Dennis Ahnen, Paul J. Limburg Coding Procedures (M06) Thomas M. Deas

Hepatitis C (M12) Donald M. Jensen

Madeline D Manchester Hyatt

Marriott Hotel & Marina

Madeline B Manchester Hyatt

Sp372

Evaluation of Malabsorption (M07) John K. DiBaise

Manchester Hyatt

Manchester Hyatt Sp369

EUS - Cases (M30) Sponsored by the ASGE EUS SIG Michael B. Wallace, Mohammad A. Al-Haddad

Sp391

Surgical Management of Achalasia (M17) Donald E. Low, Erik J. Simchuk

26B San Diego Convention Center

Sp392

The Gastrointestinal Consequences of Obesity (M15) Lee M. Kaplan Emma C

Manchester Hyatt Sp393

Using Cochrane Systemic Reviews for Clinical Practice (M21) Paul Moayyedi, Grigoris I. Leontiadis Annie A

Manchester Hyatt Sp394

What's New in Liver Tumor Ablation (M18) David M. Mahvi

26A San Diego Convention Center

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Problem-Based Learning Luncheons 12:30 PM - 1:45 PM

Participants will be able to: • Interact in a small group setting to define facts, develop hypotheses, and determine a learning agenda; • Increase participant's current knowledge of interesting gastrointestinal diseases issues; and • Evaluate this method of teaching with respect to achieving the session's objectives. Sp395

32 Year Old Woman with Fever and Jaundice and An Unusual Diagnosis (LL01) Sanjiv Chopra Edward A

Manchester Hyatt Sp396

Management of Crohn's Disease: Merging Evidence with Experience, An Interactive Session (LL02) Edward B David T. Rubin

Manchester Hyatt Sp397

Fluctuating Cholestasis in a 51 Year Old Man with a Renal Transplant: A Diagnostic Dilemma (LL04) Helen M. Shields Edward D

Manchester Hyatt Sp398

Crohn's Disease and Eosinophilic Esophagitis. What's Going On? (LL05) Harland S. Winter Betsy C

Manchester Hyatt Sp399

Colorectal Cancer Surveillance in Inflammatory Bowel Disease: Controversies and Management 2008 (LL07) Edward C Francis A. Farraye

Manchester Hyatt AASLD State-of-the-Art-Lecture 2:15 PM - 3:15 PM

6F San Diego Convention Center

DDW Combined Clinical Symposium 2:15 PM - 3:45 PM 20A San Diego Convention Center Chairs: John G. Hunter, Stuart J. Spechler Sponsored by: SSAT; AGA Institute

ESOPHAGEAL CANCER Participants will be able to: • Compare the key epidemiological features of squamous and ademocarcinoma of the esophagus, and speculate on why the incidence of ademocarcinoma is increasing so dramatically; • Discuss the lymphatic system of the esophagus and the propensity of esophageal neoplasms to metastasize; and • Discuss the various endoscopic techniques for treating esophageal cancer and the long-term outcomes. 2:15 Sp401

The Intriguing Epidemiology of Esophageal Cancer: What Factors Underlie the Trends? Stuart J. Spechler

2:30 Sp402

The Biology of Esophageal Cancer: What Factors Influence the Choice of Therapy? Jeffrey H. Peters

2:45 Sp403

Endoscopic Treatment of Esophageal Cancer Jacques J. Bergman

3:00 Sp404

Surgical Treatment of Esophageal Cancer John G. Hunter

3:15 Sp405

A Balanced Approach to the Treatment of Esophageal Cancer Charles R. Thomas

3:30

Discussion

DDW Combined Clinical Symposium 2:15 PM - 3:45 PM 20BCD San Diego Convention Center

Chair: Andrew S. Klein Chairs: Kenneth R. McQuaid, Lisa L. Strate

LIVING DONOR LIVER TRANSPLANTATION: THE TECHNOLOGICAL AND ETHICAL WAY FORWARD Participants will be able to: • Discuss organ solicitation and transplant tourism; • Present an overview of extended criteria donors (ECD) and donation after cardiac death (DCD); and • Review organ allocation and what is wrong with the current system. 2:15 Sp400

Living Donor Liver Transplantation the Technical and Ethical Way Forward Charles M. Miller

Sponsored by: ASGE; AGA Institute; SSAT

THE OPTIMAL MANAGEMENT OF LGI BLEEDING 2:15 Sp406

Why Is There so Much Controversy? Lisa L. Strate

2:45 Sp407

Should Urgent Colonoscopy Be Performed in Most Patients with Acute LGIB? Yes! Dennis M. Jensen

3:15 Sp408

Should Urgent Colonoscopy By Performed in Most Patients with Acute LGIB? No! Don C. Rockey

P-59

M O N D A Y MAY 19

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Clinical Symposium 2:15 PM - 3:45 PM 10 San Diego Convention Center Chairs: Timothy O. Lipman, Kirsten Tillisch Sponsored by: Nutrition & Obesity; Immunology, Microbiology & Inflammatory Bowel Disease; Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Liver & Biliary

3:01 Sp417

Does Measuring Gastric Accommodation and Motility Guide Therapy? Guy E. Boeckxstaens

3:23 Sp418

Summary: Where Are We Now and Where Do We Need to Go? Michael D. Crowell

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM 6AB San Diego Convention Center

Participants will be able to: • Discuss the evidence presented for CAM as it impacts gastrointestinal and liver disease; and • Present arguments for and against CAM.

Chairs: John M. Inadomi, Brooks D. Cash

2:15 Sp409

CAM and the Evidence- Pro Ronald L. Koretz

3:00 Sp410

CAM and the Evidence- Con Gerard E. Mullin

Chairs: C. Prakash Gyawali, Ronnie Fass

MAY 19

Gastric Emptying Tests: Con Michael P. Jones

COMPLEMENTARY AND ALTERNATIVE MEDICINE IN GASTROINTESTINAL AND LIVER DISEASES: AN EVIDENCE-BASED APPROACH

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM 8 San Diego Convention Center

M O N D A Y

2:38 Sp416

Sponsored by: Neurogastroenterology and Motility; Clinical Practice; Esophageal, Gastric & Duodenal Disorders

EMERGING TOPICS IN FUNCTIONAL ESOPHAGEAL DISORDERS Participants will be able to: • Define emerging aspects in functional esophageal disorders; and • Define PPI failure, functional dysphagia, functional chest pain and brain gut reactions in GERD. 2:15 Sp411

PPI Failure—a Functional Esophageal Disorder or More Reflux? Daniel Sifrim

2:37 Sp412

Functional Dysphagia—Lessons from Impedance Studies Michael F. Vaezi

2:59 Sp413

Functional Chest Pain—a Growing Medical Problem Guy D. Eslick

3:22 Sp414

Is There a Role for Altered Brain Gut Interactions in GERD? C. Prakash Gyawali

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM 31BC San Diego Convention Center Chairs: Michael P. Jones, Jan F. Tack Sponsored by: Esophageal, Gastric & Duodenal Disorders; Clinical Practice; Neurogastroenterology and Motility

EVALUATING DYSPEPSIA: DOES GASTRIC FUNCTION TESTING IMPROVE OUTCOMES? Participants will be able to: • Identify indications for gastric emptying studies; and • Learn future directions of gastric accommodation evaluation. 2:15 Sp415

P-60

Gastric Emptying Tests: Pro Henry P. Parkman

Sponsored by: Clinical Practice; Imaging & Advanced Technology; Gastrointestinal Oncology

INTEGRATING CT COLONOGRAPHY INTO GI PRACTICE Participants will be able to: • Review the clinical results and implications of large scale CTC trials for CRC screening; • Identify the AGA task force recommendations surrounding the practice of CTC by gastroenterologists; and • Review the economic and legal ramifications of incorporating CTC into a gastroenterology practice. 2:15 Sp419

Update On the Evidence of CTC for CRC Screening Perry J. Pickhardt

2:45 Sp420

Clinical Utility of CTC: AGA Task Force Recommendations Joel G. Fletcher

3:15 Sp421

The Economic Realities of CTC Joel V. Brill

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM 28ABC San Diego Convention Center Chairs: Paul Moayyedi, Grigoris I. Leontiadis Sponsored by: Cochrane Upper Gastrointestinal and Pancreatic Diseases Group; Clinical Practice; Esophageal, Gastric & Duodenal Disorders

MANAGEMENT OF NON-VARICEAL BLEEDING: FROM META-ANALYSIS TO GUIDELINES Participants will be able to: • Identify the evidence for the efficacy of acid suppression in upper GI bleeding; • Summarize the evidence for the efficacy of endoscopic therapy in non-variceal bleeding; and • Evaluate the evidence for strategies to prevent non-steroidal antiinflammatory upper GI bleeding. 2:15 Sp422

Acid Suppression and Upper GI Bleeding Colin W. Howden, Grigoris I. Leontiadis

2:39 Sp423

Endoscopic Therapy in Non-Variceal Bleeding George Triadafilopoulos

3:01 Sp424

NSAID Prophylaxis for Upper GI Bleeding: When and How Loren A. Laine

3:23 Sp425

Management of Upper GI Bleeding: From EBM to Clinical Practice Richard H. Hunt

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Committee Sponsored Symposium 2:15 PM - 3:45 PM 31A San Diego Convention Center

AGA Institute Translational Symposium 2:15 PM - 3:45 PM 4 San Diego Convention Center

Chair: Andrea E. Reid

Chairs: Steven M. Cohn, Lopa Mishra

Sponsored by: Education & Training Committee

Sponsored by: Growth, Development & Aging; Liver & Biliary ; Immunology, Microbiology & Inflammatory Bowel Disease

ISSUES FACING GI FELLOWSHIP PROGRAMS Participants will be able to: • Learn how to implement the ACGME six core competencies; • Appreciate the “institutional rules” regarding salary and remuneration and learn about various opportunities to fund fellowship positions; and • Review the status of the hepatology CAQ and other 4th-year fellowships. 2:15 Sp426

Panel Discussion Deborah D. Proctor

2:45 Sp427

Panel Discussion Andrew Muir

3:15 Sp428

Panel Discussion M. Michael Wolfe

AGA Institute Overarching Basic Science Symposium 2:15 PM - 3:45 PM 29 San Diego Convention Center

PATTERNS OF PROTEIN EXPRESSION IN THE EVALUATION AND DIAGNOSIS OF GASTROINTESTINAL DISEASE Participants will be able to: • Review the technology and theory behind proteomics; • Identify the value of proteomics in understanding liver function and disease; and • Discuss the role of proteomics in inflammatory bowel disease. 2:15 Sp434

Human Liver Proteome Project Samir Hanash

2:45 Sp435

Proteomics for the Clinician: A Primer Deborah L. Diamond

3:15 Sp436

Proteomics in Inflammatory Bowel Disease Dirk Haller

ASGE Clinical Symposium 2:15 PM - 3:45 PM

Chair: Vincent W. Yang Sponsored by: AGA Institute

MICRORNA IN CANCER AND IMMUNE SYSTEMS Participants will be able to: • Discuss MicroRNA and the immune response to MicroRNA and human cancers. 2:15 Sp429

MicroRNA and the Immune Response David L. Baltimore

AGA Institute Translational Symposium 2:15 PM - 3:45 PM 30A San Diego Convention Center Chairs: Eileen Grady, Michael L. Steer Sponsored by: Pancreatic Disorders; Neurogastroenterology and Motility; Hormones, Transmitters, Growth Factors, & Their Receptors

NEUROGENIC BASIS OF PAIN IN PANCREATITIS Participants will be able to: • Identify the roles of primary sensory nerves and vagal innervation in the pathogenesis of pancreatitis. 2:15 Sp431

Neurogenic Basis for Pancreatitis Pain Pankaj J. Pasricha

2:45 Sp432

PAR-2 and Pancreatitis Nigel W. Bunnett

3:15 Sp433

The Vagus Nerve in Pancreatitis David van Westerloo

5 San Diego Convention Center

M O N D A Y

Chairs: Jonathan A. Leighton, Carol E. Semrad IMAGING THE SMALL INTESTINE 2:15 Sp437

Obscure GI Bleeding: No Longer Obscure Marco Pennazio, Amy K. Hara

2:40 Sp438

Inflammatory Diseases: Ulcers to Atrophy Carol E. Semrad, Amy K. Hara

3:05 Sp439

Tumors: Not to Be Missed Jamie S. Barkin, Amy K. Hara

3:30

MAY 19

Panel Discussion with Questions & Answers

ASGE Clinical Symposium 2:15 PM - 3:45 PM

6C San Diego Convention Center

Chairs: Paul Fockens, Grace H. Elta IT'S NOT YOUR FATHER'S ENDOSCOPE 2:15 Sp440

Improvements in the Standard Colonoscope Jacques Van Dam

2:35 Sp441

Skill-Independent Endoscopy Simon Bar-Meir

2:55 Sp442

Scoping the Entire Small Bowel Simon K. Lo

3:15

Questions & Answers

P-61

ORAL SESSIONS—SCIENTIFIC SESSIONS ASGE Special Session 2:15 PM - 3:45 PM

11 San Diego Convention Center

AGA Institute Research Forum 2:15 PM - 3:45 PM

Chairs: Douglas O. Faigel, Irving M. Pike

Chairs: Herbert C. Wolfsen, Oleh Haluszka

QUALITY INDICATORS IN ENDOSCOPY: HOW IT AFFECTS YOUR PRACTICE

Sponsored by: Imaging & Advanced Technology

2:15 Sp443

The Alphabet Soup of P4P: CMS, PQRI & U Brian C. Jacobson

2:30 Sp444

P4P in the Private Sector: Challenges and Opportunities Thomas M. Deas

2:45 Sp445

Quality Benchmarking for Endoscopy Irving M. Pike

3:00 Sp446

Bringing Quality Measurement to Your Practice Joseph J. Vicari

3:15

Questions & Answers

AASLD Young Investigator Plenary 2:15 PM - 3:55 PM 7A San Diego Convention Center

ADVANCES IN COLONIC IMAGING Participants will be able to: • Become familiar with the advances in colonic imaging. 2:15 #280

Sensitivity Comparison Between Human Readers and Computer-Aided Diagnosis Software in the Detection of Polyps in Large-Scale Multicenter Clinical Trials On Virtual Colonoscopy Hiroyuki Yoshida, Janne Näppi, Koichi Nagata*, Don C. Rockey

2:37 #281

Novel Confocal Endomicroscope Using Structured Light Illumination Nenad Bozinovic, Cathie Ventalon, Christopher D. Atkinson, Jerome Mertz, Satish K. Singh*

2:59 #282

PillCam® Colon Capsule Endoscopy Compared to Colonoscopy in Detection of Colon Polyps and Cancers Jacques M. Deviere*, Miguel A. Munoz-Navas, Ignacio Fernandez-Urien, Cristina Carretero, Gerard Gay, Michel Delvaux, Marie George Lapalus, Thierry Ponchon, Guido Costamagna, Maria Elena Riccioni, Cristiano Spada, Horst Neuhaus, Michael Philipper, David M. Frazer, Aymer Postgate, Aine Fitzpatrick, Fritz Hagenmuller, Martin Keuchel, Nathalie Schoofs, Andre M. Van Gossum

3:21 #283

Endomicroscopy for In Vivo Analysis of Bacterial Translocation in IBD Ralf Kiesslich*, M. Kerner, Martin Goetz, Driffa Moussata, Arthur Hoffman, Peter R. Galle, Markus F. Neurath

Chairs: Gregory J. Gores, Guadalupe Garcia-Tsao YOUNG INVESTIGATOR PLENARY I

M O N D A Y MAY 19

30B San Diego Convention Center

2:15 #275

Specific MicroRNA Are Differentially Expressed and Dysregulate the Unfolded Protein Response in Nonalcoholic Steatohepatitis Onpan Cheung*, Puneet Puri, Faridoddin Mirshahi, Haeki Min, Huiping Zhou, John M. Kellum, James W. Maher, Velimir A. Luketic, Michael Fuchs, Arun J. Sanyal

2:25

Discussion

2:35 #276

Serum Autoantibodies Reactive to Cholangiocyte Cytosolic Proteins in Murine Biliary Atresia Brandy Lu*, Stephen M. Brindley, Rebecca Tucker, Cherie Lambert, Cara L. Mack

AGA Institute Research Forum 2:15 PM - 3:45 PM

2:45

Discussion

Chairs: Douglas A. Corley, Nimish Vakil

2:55 #277

SREBP1C, Regulated By the Insulin, AMPK, and LXRα Signaling Pathways, Plays a Role in NAFLD: Importance of Cholesterol~Lxra~SREBP1C Axis and the Cholesterol Metabolism Makoto Nakamuta*, Ryoko Yada, Masayoshi Yada, Tatsuya Fujino, Nobito Higuchi, Masaki Kato, Tsuyoshi Yoshimoto, Ryosuke Takemoto, Kunitaka Fukuizumi, Naohiko Harada, Kazuhiro Kotoh, Munechika Enjoji

Sponsored by: Clinical Practice

3:05

Discussion

3:15 #278

Caspase Activity Mirrored By Plasma Cytokeratin-18 Fragments' Level Predicts Advanced Hepatic Fibrosis Related to Non Alcoholic Fatty Liver Disease and Chronic Viral Hepatitis Hesham M. Elgouhari*, Nizar N. Zein, Ahmed G. Elsayed, Anas Kutait, Lisa M. Yerian, Rocio Lopez, Ariel E. Feldstein

3:25

Discussion

3:35 #279

Sulf2 Up-Regulates Glypican 3, Promotes FGF Signaling, and Decreases Survival of Patients with Hepatocellular Carcinoma (HCC) Jin-Ping Lai*, Dalbir S. Sandhu, Tao Han, Catherine D. Moser, Abdirashid M. Shire, Ju-Seog Lee, Snorri Thorgeirsson, Lewis Roberts

3:45

P-62

Discussion

3 San Diego Convention Center

EPIDEMIOLOGY OF GERD AND ITS COMPLICATIONS Participants will be able to: • Review the latest information on the incidence of Barrett's Esophagus; • Discuss the influence of PPI therapy on Barrett's Esophagus and the development of esophageal cancer; and • Understand the prevalence of GERD in different racial groups. 2:15 #284

Trends in the Incidence of Barrett's Esophagus in the Netherlands 1991-2006 P. J. de Jonge*, M. van Blankenstein, Caspar W. Looman, M. K. Casparie, Gerrit A. Meijer, E. J. Kuipers

2:30 #285

The Extent and Duration of Using Acid Reducing Medications in Patients with Barrett's Esophagus Hashem B. El-Serag*, Peter Richardson

2:45 #286

PPI Use and the Risk of Esophageal Cancer in Patients with BE: A Nested Case-Control Study Hashem B. El-Serag*, Peter Richardson

3:00 #287

Atypical Symptoms of Gastroesophageal Reflux During Pregnancy Enrique Rey*, Fernando Rodriguez Artalejo, Miguel Angel Herraiz, Angel Alvarez Sanchez, Cristina Almansa, Manuel Escudero, Manuel Diaz-Rubio

ORAL SESSIONS—SCIENTIFIC SESSIONS 3:15 #288

Trends in the Endoscopic Spectrum of GERD Among a Large Cohort of Patients Zarema Singson*, Kenneth Vega, M Mazen Jamal

3:30 #289

Gastro-Esophageal Reflux Disease (GERD) Is More Common in Hispanic Than African American, Asian, and Caucasian, Populations in the United States Elaine Yuen*, Richard W. Toner, Nicole M. Cobb, Philip Katz, Maya Spodik, Neil I. Goldfarb

AGA Institute Research Forum 2:15 PM - 3:45 PM

30C San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility

IBS: STRESS AND IMMUNE MECHANISMS Participants will be able to: • Understand the etiology of IBS; and • Understand the role of immune cells in brain-gut interactions. 2:15 #290

Stress Induced Visceral Hypersensitivity After Maternal Separation in Rats Is Transferred Across Generations in a Behavioral and Mast Cell Dependent Fashion Rene M. van den Wijngaard*, Olaf Welting, Wouter de Jonge, Guy E. Boeckxstaens

2:30 #291

Corticotropin Releasing Factor (CRF) in Rat Colon: Expression, Localization and Regulation By Stress Pu-Qing Yuan*, Shuping V. Wu, Mulugeta Million, Muriel H. Larauche, Lixin Wang, Yvette Tache

2:45 #292

Neonatal Inflammatory Stress Reprograms Gene Transcription of Cell Signaling Proteins to Cause Colonic Motility Dysfunction in Adulthood Barun K. Choudhury*, Xuan-Zheng P. Shi, Sushil K. Sarna

3:00 #293

Increased Intraepithelial Lymphocytes and Mast Cells with Depressed Serotonin Transporter in Duodenal Biopsies and Platelets of Patients with IBS and Diarrhoea (IBS-D): Correlation with Bowel Frequency Stephen J. Foley*, Gulzar Singh, Laurie C. Lau, Andrew F. Walls, Geoffrey K. Holmes, Andrew Bennett, Charles Marsden, Robin C. Spiller

3:30 #295

33BC San Diego Convention Center

Chairs: Miles Parkes, Richard H. Duerr Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IMIBD GENETICS IN IBD

Chairs: Arnold Wald, Birgit Adam

3:15 #294

AGA Institute Research Forum 2:15 PM - 3:45 PM

Mast Cell Alterations in Post-Infectious Functional Gastrointestinal Disorders: Are They Related to the Disorder or to the Infection? Antonia Perello*, Fermin Mearin, Josep Lloreta, Agustin Balboa, Monica Perona, Antonio Salas, Marc Perez-Oliveras, Jordi Coderch Dysfunctional T Cell Responses After Polyclonal Stimulation in Patients with Irritable Bowel Syndrome (IBS) Lena Ohman*, Ann-Charlotte Lindmark, Stefan Isaksson, Iris Posserud, Hans Strid, Henrik Sjövall, Magnus Simren

Participants will be able to: • Be familiar with the advances in genome wide association studies for Crohn's disease; • Be familiar with the advances in the association of the NOD2 gene with Crohn's disease; and • Be familiar with the association of the major HLA locus in inflammatory bowel disease. 2:15 #296

Expression Analysis of All Genes Implicated in Susceptibility to Crohn's Disease from Genome-Wide Association Studies Charles W. Lees*, Colin L. Noble, Lauri Diehl, Jack Satsangi

2:30 #297

Replication of Signals from Recent Genome Wide Association Studies in Crohn Disease Identifies New Disease Genes for Ulcerative Colitis in a Large German Patient Panel Andre Franke*, Tobias C. Balschun, Jürgen Hedderich, Tom Hemming Karlsen, Sandra May, Timothy T. Lu, Dörthe Schuldt, Philip C. Rosenstiel, Michael Krawczak, Stefan Schreiber

2:45 #298

The Genetics of Nod-like Receptor Proteins in Crohn's Disease Fraser Cummings*, Rachel M. Cooney, Geraldine Clarke, John B. Beckly, Alessandra Geremia, Lon R. Cardon, Derek P. Jewell

3:00 #299

A High Density Association Study of the Extended Major Histocompatibility Locus in Ulcerative Colitis and Crohn's Disease Philippe Goyette*, Todd Green, Paul de Bakker, Christine Stevens, Anna Latiano, Jorge R. Oksenberg, Steven L. Hauser, Vito Annese, Mark J. Daly, John D. Rioux

3:15 #300

Genetic Variation in BTLA Is Strongly Associated with Crohn's Disease Ling Mei*, Kent D. Taylor, Carol J. Landers, Dermot P. McGovern, Stephan R. Targan, Jerome I. Rotter

3:30 #301

The -360T/C Polymorphism in the TNFSF15 Gene Influences the Transcriptional Activity in Activated T Lymphocytes Nobuo Ueki*, Yoshitaka Kinouchi, Yoichi Kakuta, Katsuya Endo, Eiki Nomura, Kenichi Negoro, Seiichi Takahashi, Tooru Shimosegawa

P-63

M O N D A Y MAY 19

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 2:15 PM - 3:45 PM

9 San Diego Convention Center

2:30 #309

E-Cadherin/Beta-Catenin Dissociation Results in Altered Wnt/β-Catenin Signaling: A Mechanism for Villus Atrophy in a Mouse Model of Total Parental Nutrition Yongjia Feng*, Xiaoyi Sun, Hua Yang, Keisuke Nose, Hiroyuki Koga, Daniel H. Teitelbaum

2:45 #310

Aryl Hydrocarbon Receptor Pathway Modulates the Activity of Colitis Violeta Arsenescu, Jian Zhong, Razvan I. Arsenescu*, Willem J. de Villiers, Hollie I. Swanson

3:00 #311

Altered Duodenal Sweet Taste Receptor Expression in Diabetic Hyperglycemia Kate Sutherland*, Stuart M. Brierley, Chris Rayner, Michael Horowitz, L. Ashley Blackshaw, Richard L. Young

3:15 #312

The Pathogenicity of Citrobacter rodentium (Cr) Is Enhanced in Mice Fed Diets Deficient in Selenium (Se) and Vitamin E (VE) Allen Smith*, Sebastian Botero, Terez Shea-Donohue

3:30 #313

Glutamine Regulates Autophagy in IEC-18 Cells Toshio Sakiyama*, Mark W. Musch, Mark J. Ropeleski, Hirohito Tsubouchi, Eugene B. Chang

Chairs: Lee Denson, Monica Boirivant Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IN VIVO REGULATION OF T CELLS BY ANTIGEN PRESENTING CELLS (APC) Participants will be able to: • Understand how dendritic cells influence regulatory T cells; • Understand In Vivo function of innate immune cells in regulating effector t cells in colitis models; and • Understand how bacterial DNA stimulates regulatory responses.

M O N D A Y

2:15 #302

Macrophage Deletion of CD44v7 Induces Tolerance in Transfer Colitis By Induction of FOXP3 Positive Treg Cells Pamela Holzloehner*, Katja Heilmann, Christoph Loddenkemper, Martin Zeitz, Ursula Günthert, Bianca M. Wittig

2:30 #303

Systemic Control of Plasmacytoid Dendritic Cells By CD8+ T Cells and Commensal Microbiota Daisuke Fujiwara*, Bo Wei, Laura L. Presley, Sarah N. Brewer, Michael McPherson, James Borneman, Jonathan Braun

2:45 #304

T-Cell-Dependent Protective Effects of CpG-ODN in Experimental Colitis Are Mediated By CD11c+ Dendritic Cells Claudia Hofmann*, Nadja Dunger, Nicole Grunwald, Guenter Haemmerling, Juergen Schoelmerich, Werner Falk, Florian Obermeier

3:00 #305

Abnormal Innate Immune Cells Can Induce Colitogenicity in Normal Adaptive Immune Cells Deanna D. Nguyen*, Elisa K. Boden, Michel H. Maillard, Cathryn R. Nagler, Scott B. Snapper

3:15 #306

Deletion of CD47 Protects from Murine Experimental Crohn's Disease Genevieve Fortin*, Marianne Raymond, Manuel A. Rubio, Catherine Collette, Alexandra-Chloe Villani, Marika Sarfati, Denis Franchimont

MAY 19

3:30 #307

Distinct Regulatory Dendritic Cell Subsets in Control of Treg Function in Acute Inflammation and Recovery from Colitis Seiji Arihiro*, Bayasi Guleng, Carmen Alonso Cotoner, Jan H. Niess, Sonal Gupta, Joel V. Weinstock, Hans-Christian Reinecker

AGA Institute Research Forum 2:15 PM - 3:45 PM

AGA Institute Research Forum 2:15 PM - 3:45 PM

Chairs: Sushovan Guha, Marcia I. Canto Sponsored by: Gastrointestinal Oncology

PANCREATIC CANCER: BIOLOGY, DIAGNOSIS AND TREATMENT Participants will be able to: • Review biology, diagnosis and treatment in pancreatic cancer. 2:15 #314

The Novel Biomarker (HOXB2) Predicts Response to Pancreatectomy for Pancreatic Cancer Andrew V. Biankin*, James G. Kench, Devendra Segara, David A. Skalicky, Sandra A. Biankin, Nam Q. Nguyen, Neil Merrett, Robert L. Sutherland, Susan M. Henshall, Elizabeth A. Musgrove

2:30 #315

Conditional Deletion of ERBB2/Neu Inhibits Pancreatic Tumorigenesis Martin Majer, Phillip Gray, Xiufen Li, Lyska L. Emerson, Scott K. Kuwada*

2:45 #316

The Phenotype of Familial Pancreatic Neoplasia Marcia I. Canto*, Michael G. Goggins, Richard D. Schulick, Charles J. Yeo, Elliot K. Fishman, Ihab R. Kamel, John L. Cameron, Alison P. Klein, Ralph H. Hruban

3:00 #317

Pancreatic Cancer Biomarkers in Saliva James J. Farrell*, Bernhard Zimmerman, Ali Ammar, Hui Zhou, Qing Wei, Wael Ghacham, Brad Henson, David T. Wong

3:15 #318

Early Vaccination Targeting Mutated KRAS As An Antigen Expressed By Panins Delays Progression to Pancreatic Tumors in a Mouse Model Michel Kafrouni*, Todd Armstrong, Elizabeth M. Jaffee

3:30 #319

Role of Different Subunits of NADPH Oxidase in IGF-IInduced ROS Production and Pro-Survival Effect in Pancreatic Cancer Cells Mouad Edderkaoui*, Claudia J. Nitsche, Guido Eibl, Anna S. Gukovskaya

26A San Diego Convention Center

Chairs: Mark T. Worthington, Dennis D. Black Sponsored by: Nutrition & Obesity

NUTRIENTS AND GUT FUNCTION: CELL SIGNALING, IMMUNITY AND OTHER FUNCTIONS Participants will be able to: • Learn about novel basic research in nutrients and their role in regulating cell signaling, immunity and other gut functions. 2:15 #308

P-64

Glucose-Dependent Insulinotropic Polypeptide (GIP) Enhances Adipocyte Development and Modulates Multiple Downstream Targets of AKT Diane H. Song, T. Carlton Moore*, M. Michael Wolfe

26B San Diego Convention Center

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 2:15 PM - 3:45 PM

33A San Diego Convention Center

Chair: Sergey V. Kantsevoy Sponsored by: Liver & Biliary; Gastrointestinal Oncology

HEPATOBILIARY CARCINOMA: DIAGNOSIS AND MANAGEMENT Participants will be able to: • Become familiar with recent hepatobiliary carcinoma clinical research findings their implications; • Discuss new findings regarding treatment of hepatobiliary carcinoma; and • Learn basic mechanisms and emerging therapies for hepatobiliary carcinoma. 2:15 #320

VEGF-D Promotes Tumor Growth and Lymphatic Spread in Hepatocellular Carcinoma Armin Thelen, Arne Scholz*, Christoph Benckert, Maik Schröder, Peter Neuhaus, Bertram Wiedenmann, Sven Jonas

2:30 #321

Hepatocellular Carcinoma in a Non-Cirrhotic Liver: Presentation of a Medico-Surgical Series of 40 Cases Edwige Morineaux, Anne-Marie Marion-Audibert*, Philippe Merle, Sylvie Radenne, Brigitte Bancel, Jacques Baulieux, Fabien Zoulim, Christian Ducerf, Jean Christophe Souquet, Christian Trepo

2:45 #322

3:00 #323

Photodynamic Therapy Versus Incomplete Resection in Hilar Cholangiocarcinoma Thomas Zoepf*, Gernot M. Kaiser, Alexander Dechene, Philip A. Hilgard, Guido Gerken, Hauke Lang Surgical Resection Versus Percutaneous Radiofrequency Ablation in Treatment of Hepatocellular Carcinoma: A Meta Analysis Sathya Jaganmohan*, Suneal Agarwal, Krishna S. Kasturi, Gagan Sood

3:15 #324

Bone Marrow-Derived Liver-Committed Stem Cells Give Rise to Combined Hepatocholangio-Carcinomas in Rats A. Piscaglia*, Thomas Shupe, Marialuisa Novi, Mariachiara Campanale, Antonio Gasbarrini, Bryon E. Petersen

3:30 #325

PRAJA, An E3 Ligase, May Promote Hepatocellular Carcinoma Through TGF-β Dependent Ubiquitination of ELF and SMAD3, and Via Anti-Apoptotic Activity Viveka Mishra*, Rupen Amin, Geeta Upadhyay, Eric Glasgow

ASGE Topic Forum 2:15 PM - 3:45 PM

2:39 #328

Early Versus Delayed Feeding After Placement of a Percutaneous Endoscopic Gastrostomy: A Meta-Analysis Matthew L. Bechtold*, Michelle L. Matteson, Abhishek Choudhary, Srinivas R. Puli, Peter P. Jiang, Praveen K. Roy

2:51 #329

Cervical Esophageal Perforations At the Time of Endoscopic Ultrasound: A Prospective Evaluation of Frequency, Outcomes, and Patient Management Mohamad A. Eloubeidi*, Ashutosh Tamhane

3:03 #330

Drainage Percutaneous Endoscopic Gastrostomy Tube Placement in the Setting of Ascites Anjani Jammula*, Mark L. Greaves, Mark A. Schattner, Moshe Shike

3:15 #331

TSE “Mask” Improves Oxygenation and Decreases Requirements for Airway Assistance in Deeply Sedated Patients During Lengthy Upper Endoscopic Procedures Tamir Ben-Menachem*, Shaul Cohen, Ahdev Kuppusamy, Shruti Shah, Deena New, Christine W. Hunter, Chirag Trivedi, James Tse

3:27 Sp447

State-of-the-Art Lecture: Comfort, Control and Cost in Endoscopy Martin L. Freeman

ASGE Topic Forum 2:15 PM - 3:45 PM

Chairs: John E. Pandolfino, David A. Johnson GERD: DETECTION, MANAGEMENT, AND FOLLOW-UP 2:15 #332

Endoscopic Full-Thickness Plication for the Treatment of GERD: Five Year Multi-Center Results Douglas Pleskow, Richard I. Rothstein, Richard A. Kozarek, Gregory B. Haber, Christopher J. Gostout, Simon K. Lo, Robert H. Hawes, Anthony Lembo*

2:27 #333

The Association Between Cholecystectomy and Gastroesophageal Reflux Symptoms Otto Lin*, Richard A. Kozarek

2:39 #334

Underdiagnosed Esophageal Ulcers in Patients Treated with Cardiac Catheter Radiofrequency Ablation for Atrial Fibrillation: Results of An Ongoing Prospective Trial Kenneth A. Seres*, Richard F. Harty, Karen Beckman, Hiroshi Nakagawa, William M. Tierney

2:51 #335

Efficacy of Intelligent Chromo Endoscopy for Detection of Minimal Mucosal Breaks in Patients with Typical Symptoms of Gastroesophageal Reflux Disease Roongruedee Chaiteerakij, Nopavut Geratikornsupuk, Nathaya Tangmankongworakoon, Sutep Gonlachanvit, Sombat Treeprasertsuk, Rungsun Rerknimitr*, Pinit Kullavanijaya

3:03 #336

Dilated Intrapapillary Capillary Loops By Magnifying Endoscopy: Usefulness for Diagnosis of GERD Ryo Kosaka*, Kyosuke Tanaka, Hideki Toyoda, Yasuhiko Hamada, Masatoshi Aoki, Tomohiro Noda, Ichiro Imoto, Yoshiyuki Takei, Masato Nagahama

3:15 #337

The Reliability of Ultra-Thin Endoscope for Diagnosis of Milder Form of Esophagitis Compared to Standard Endoscope Yoshio Hoshihara*, Naohisa Yahagi, Michio Hongo

3:27 Sp448

State-of-the-Art Lecture: What Do We Know About the Natural History of GERD? Reza Shaker

1 San Diego Convention Center

Chairs: John J. Vargo, John Baillie ADVANCES IN ENDOSCOPIC PRACTICE: MAXIMIZING PATIENT SAFETY AND COMFORT 2:15 #326

Capnography Prevents Hypoxemia During ERCP and EUS: A Randomized Controlled Trial Mohammed A. Qadeer*, John J. Vargo, John A. Dumot, Gregory Zuccaro, Tyler Stevens, Mansour A. Parsi, Madhusudhan R. Sanaka, Sunguk Jang, Rocio Lopez

2:27 #327

Gastroenterologist-Directed, Balanced Propofol Sedation for EGD and Colonoscopy: An Analysis of Safety in 15,286 Patients Andrew E. Dikman*, Shefali Sanyal, James Aisenberg, Kenneth M. Miller, Lawrence B. Cohen

2 San Diego Convention Center

M O N D A Y MAY 19

P-65

ORAL SESSIONS—SCIENTIFIC SESSIONS SSAT Plenary Session 2:15 PM - 5:00 PM

24ABC San Diego Convention Center

4:45 #348

Increasing Regionalization of Hepatic Resection in Canada: 1995-2004 Ryan McColl*, Xiaoqing You, William A. Ghali, Elijah Dixon

Chairs: Gerard V. Aranha, Donald E. Low SSAT PLENARY SESSION III Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 2:15 #338

Cervical Nodal Metastasis from Intrathoracic Esophageal Squamous Cell Carcinoma Is Not Necessarily An Incurable Disease Daniel K. Tong*, Simon Law, Kam Ho Wong, John Wong

2:30 #339

The 3-Year Outcome of Optimal Medical or Surgical Management of GERD Patients with Barrett's Esophagus: The Lotus Trial Experience Stephen E. Attwood*, Lars R. Lundell, Jan G. Hatlebakk, Stefan Eklund, Ola Junghard, Jean Paul Galmiche, Christian Ell, Roberto Fiocca, Tore Lind

2:45 #340

M O N D A Y

Zenker's Diverticula: Is a Tailored Approach Feasible? Christian Rizzetto, Mario Costantini*, Raffaele Bottin, Elena Finotti, Lisa Zanatta, Martina Ceolin, Loredana Nicoletti, Giovanni Zaninotto, Ermanno Ancona

3:00 #341

Quality of Life and Symptomatic Response to Gastric Neurostimulation for Gastroparesis Vic Velanovich

3:15 #342

Results of the Surgical Treatment of Cardia Carcinoma (Ca) Characterized By Outcome and Perioperative Factors in a Prospective Observational Multicentre Study for Quality Control Lutz Meyer*, Olof Jannasch, Frank Meyer, Hans Lippert, Ingo Gastinger

MAY 19

SSAT Conference/Debate/Panel/Symposium 2:15 PM - 5:00 PM 25 San Diego Convention Center Chair: Richard Hodin Sponsored by: AGA Institute; ASGE

SSAT/AGA/ASGE STATE-OF-THE-ART CONFERENCE: OPTIMAL TIMING OF SURGERY FOR IBD Participants will be able to: • Know the indications for surgery in patients with crohns disease and ulcerative colitis; • Develop a rational approach to the optimal timing for surgical interventions in IBD patients; and • Understand those factors that predispose to complications in IBD patients undergoing surgery. 2:15 Sp449

Introduction Richard Hodin

2:20 Sp450

Pregnancy: Before, During, and After Robin S. McLeod

2:45 Sp452

An Updated Approach to Dysplasia in IBD David T. Rubin

3:10 Sp453

Fulminant Colitis Bruce E. Sands

3:35 Sp454

Pyogenic Complications of Crohns James W. Fleshman

4:00

Case Presentations

4:40

Q&A

3:30 #343

Probiotics Improve Weight Loss, GI-Related Quality of Life and H2 Breath Tests After Gastric Bypass Surgery: A Prospective Randomized Trial Gavitt A. Woodard*, Joseph Peraza, John Downey, Betsy Encarnacion, John M. Morton

SSAT Video Session 2:30 PM - 4:00 PM

3:45 #344

Factors Related to Anastomotic Dehiscence and Mortality After Terminal Stomal Closure in the Management of Patients with Severe Secondary Peritonitis Jose L. Martinez*, Pablo Andrade, Enrique Luque-de-Leon

SSAT VIDEO SESSION I: HPB SURGERY

27B San Diego Convention Center

Chairs: Rebecca M. Minter, Randall S. Zuckerman

2:30 #349

Video: The Lateral Laparoscopic Approach to Lesions in the Posterior Segments Andrew A. Gumbs*, Brice Gayet

4:00 #345

Predictors of Survival in 865 Patients with Acinar Cell Carcinoma of the Pancreas: Survival After Surgery Compared to Ductal Adenocarcinoma C. Max Schmidt*, Jesus M. Matos, David J. Bentrem, Mark S. Talamonti, Keith D. Lillemoe, Karl Y. Bilimoria

2:48 #350

Small Diameter Prosthetic H-Graft Portacaval Shunt for Portal Decompression Alexander S. Rosemurgy*, Harold Paul, Mark Shapiro, Desiree Villadolid, Sam Al-Saadi, Sharona B. Ross, Sarah Cowgill

4:15 #346

Preoperative Liver Function Tests and Hemoglobin Will Predict Complications Following Pancreaticoduodenectomy Christopher D. Hughes*, Karen Rychlik, Margo Shoup, Gerard V. Aranha

3:06 #351

Functional Magnetic Resonance Imaging of Pancreatic Disease Tara S. Kent*, Ivan Pedrosa, Sunil Sheth, Alphonso Brown, Mark P. Callery, Charles M. Vollmer

4:30 #347

Surgical Management of Early Hepatocellular Carcinoma: Resection or Transplantation? Emily C. Bellavance*, Steven Cunningham, Kimberly M. Lumpkins, Warren R. Maley, Cinthia Drachenberg, Richard D. Schulick, Andrew M. Cameron, Michael Choti, Nader Hanna, Benjamin Philosophe, Timothy M. Pawlik

3:24 #352

Laparoscopic Extended Distal Pancreatectomy for Tumors of the Pancreatic Neck Christos A. Galanopoulos*, D. Rohan Jeyarajah

3:42 #353

Laparoscopic Approach in Patients with Gastrinoma Which Are the Limits? Laureano Fernández-Cruz

P-66

ORAL SESSIONS—SCIENTIFIC SESSIONS DOW Nurses Program 3:00 PM - 5:00 PM

Marina Ballroom, Salon G Marriott Hotel & Marina

Chairs: Malcolm S. Branch, Dariele Burchfield DDW NURSES PROGRAM (PART II) 3:00 Sp455

DDW Nurses Program (Part II) Robert Beebe, Jeanetta Blakely, Malcolm S. Branch, Dariele Burchfield, Thomas DeSimio, Paul S. Jowell, K. Jane Malick, Shawnda Rochon

AGA Institute Committee Sponsored Symposium 4:00 PM - 5:15 PM 26A San Diego Convention Center Sponsored by: Practice Management & Economics Committee

“INCIDENT TO” - MEDICARE'S DIRTY LITTLE SECRET Participants will be able to: • Discuss federal regulations for billing services provided by someone other then the physician; • Learn how private payers view the billing for services provided by someone other then the physician; and • Discuss when services can be “shared” by the physician and the Midlevel provider, and maximize revenue and minimize audit risk. 4:00 Sp456

“Incident to” - Medicare's Dirty Little Secret Cecile M. Katzoff

DDW Combined Clinical Symposium 4:00 PM - 5:30 PM 20BCD San Diego Convention Center Chairs: Nathan M. Bass, John M. Morton Sponsored by: AASLD; SSAT

MEDICAL AND SURGICAL MANAGEMENT OF NAFLD 4:00 Sp457

The Pathogenesis of NAFLD - the Rational Basis for Treatment Strategies Stephen H. Caldwell

4:30 Sp458

The Medical Management of NAFLD Paul Angulo

5:00 Sp459

The Surgical Management of NAFLD John M. Morton

DDW Combined Clinical Symposium 4:00 PM - 5:30 PM 20A San Diego Convention Center Chairs: Douglas B. Evans, William R. Brugge Sponsored by: SSAT; ASGE; AGA Institute

PANCREATIC CANCER 4:00 Sp460

The Importance of Pretreatment Radiographic Staging: Definitions of Resectable, Borderline Resectable and Locally Advanced Pancreatic Cancer Chuslip Charnsangavej

4:10 Sp461

Preoperative Biliary Stenting for Resectable Disease: Current Controversy and the Role for Metal vs. Plastic Peter B. Kelsey

4:20 Sp462

Endoscopic Ultrasound-Guided FNA: Should It Be Routine in Patients with Localized Pancreatic Cancer Michael J. Levy

4:30 Sp463

Patient Selection for Surgery: Diagnostic and Treatment Sequencing Mark P. Callery

4:40

Case Presentations

AASLD Clinical Symposium 4:00 PM - 5:30 PM

6F San Diego Convention Center

Chairs: Sammy Saab, Arun J. Sanyal REFRACTORY ASCITES Participants will be able to: • Understand the pathophysiology for the development of refractory ascites; • Define the clinical impact of refractory ascites on quality of life, morbidity, and mortality; and • Understand current and future therapies for refractory ascites. 4:00 Sp464

Pathophysiology and Diagnosis of Refractory Ascites Vicente Arroyo

4:20 Sp465

Clinical Impact of Refractory Ascites Sammy Saab

4:40 Sp466

Current Treatments Arun J. Sanyal

5:00 Sp467

Future Therapies Florence Wong

5:20

Panel Discussion

AGA Institute Clinical Symposium 4:00 PM - 5:30 PM 6AB San Diego Convention Center Chairs: Prateek Sharma, Sheila E. Crowe Sponsored by: Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Gastrointestinal Oncology; Liver & Biliary; Neurogastroenterology and Motility; Immunology, Microbiology & Inflammatory Bowel Disease

EMERGING THERAPIES FOR GI AND LIVER DISEASES Participants will be able to: • Review the latest medical and endoscopic therapies for GERD; • Summarize the role of current and emerging medical therapies for inflammatory bowel disease; and • Discuss novel treatment modalities for functional bowel disorders and liver diseases. 4:00 Sp468

Emerging Therapies in GERD Peter J. Kahrilas

4:23 Sp469

Emerging Therapies in IBD Stephen B. Hanauer

4:46 Sp470

Emerging Therapies in Functional GI Disorders William D. Chey

5:08 Sp471

Emerging Therapies in Viral Hepatitis Anna S. Lok

P-67

M O N D A Y MAY 19

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Committee Sponsored Symposium 4:00 PM - 5:30 PM 30A San Diego Convention Center

AGA Institute State-of-the-Art-Lecture 4:00 PM - 5:00 PM 32AB San Diego Convention Center

Chair: Joel V. Brill

Chairs: Maria T. Abreu, Jonathan P. Katz

Sponsored by: Practice Management & Economics Committee; Clinical Practice & Quality Management Committee; Clinical Practice

Sponsored by: Gastrointestinal Oncology; Hormones, Transmitters, Growth Factors, & Their Receptors

IS THE GASTROENTEROLOGY PATIENT CENTERED MEDICAL HOME THE NEXT PRACTICE PARADIGM? Participants will be able to: • Understand the patient centered medical home (PCMH) concept and operational structure and how it could potentially affect the practice and delivery of digestive disease care by gastroenterology and hepatology specialists; • Understand which gastrointestinal conditions lend themselves to a GI patient centered medical home practice and understand how practices can take specific steps to meet the challenge of price and quality transparency; and • Understand how GI practices can package cognitive and procedural care, risk stratification and recall systems, to enhance GI practice success.

M O N D A Y MAY 19

4:00 Sp472

What Is the Patient Centered Medical Home? Ronald P. Fogel

4:23 Sp473

Can Gastroenterologists Be a PCMH? Would We Want to? Carla H. Ginsburg

4:46 Sp474

How GI Practices Can Meet the Challenges of Price and Quality Transparency John I. Allen

5:08 Sp475

GI Practice Redesign to Enhance Practice Success Joel V. Brill

AGA Institute State-of-the-Art-Lecture 4:00 PM - 5:00 PM 2 San Diego Convention Center Chair: Bishr Omary Sponsored by: Intestinal Disorders; Nutrition & Obesity ; Clinical Practice; Growth, Development & Aging; Neurogastroenterology and Motility

FUTURE THERAPIES FOR CELIAC DISEASE Participants will be able to: • Learn about chemical features of gluten that can contribute to the autoimmunity of celiac disease; • Become familiar with potential for therapies that inhibit transglutaminase, a main autoantigen in celiac disease; and • Learn potential for therapies using gluten peptide analogues. 4:00 Sp476

Future Therapies for Celiac Disease Chaitan Khosla

INFLAMMATION, STEM CELLS AND GI CANCER Participants will be able to: • Identify the mechanisms by which inflammation causes GI cancer; and • Describe the cross talk between inflammation, innate immunity and cancer. 4:00 Sp477

AGA Institute Translational Symposium 4:00 PM - 5:30 PM 29 San Diego Convention Center Chair: Kim E. Barrett Sponsored by: Nutrition & Obesity; Immunology, Microbiology & Inflammatory Bowel Disease; Neurogastroenterology and Motility

THE HUMAN MICROBIOME Participants will be able to: • Describe the effects of antibiotics on the gut microbiome; and • Discuss the microbial regulation of host nutrient metabolism. 4:00 Sp478

Inflammatory Bowel Disease and the Microbial Ecology Daniel Frank

4:30 Sp479

The Effect of Antibiotics On the Gut Microbiome Les Dethlefsen

5:00 Sp480

Microbial Regulation of Host Nutrient Metabolism John F. Rawls

ASGE Clinical Symposium 4:00 PM - 5:30 PM

1 San Diego Convention Center

Chairs: John A. Martin, Bret T. Petersen HOT TOPICS IN ERCP 4:00 Sp481

Look, Light and Listen: Latest in Endoscopic Biliary Diagnostics Bret T. Petersen

4:20 Sp482

Biliary Therapeutic Techniques and Technologies: The Cutting Edge Michel Kahaleh

4:40 Sp483

ERCP in Pancreatic Disease: Improving Impact Paul Fockens

5:00

P-68

Inflammation, Innate Immunity and GI Cancer Michael Karin

Questions & Answers

ORAL SESSIONS—SCIENTIFIC SESSIONS AASLD Topic Forum 4:00 PM - 5:30 PM

7B San Diego Convention Center

Chairs: Paul Martin, Steven D. Colquhoun LIVER TRANSPLANTATION: IMMUNOSUPPRESSION, COMPLICATIONS AND OUTCOMES 4:00 #354

Impact of Hepatitis C Treatment On Liver Histology in Post Liver Transplant Patients Reem Ghalib*, Cheryl D. Levine, F. B. Hollinger, Rise Stribling, Terry D. Box, William Hutson, Anthony B. Post, Shobha N. Joshi, Anisha Steephen, Jeffrey Weinstein, Alejandro Mejia, Stephen Cheng

4:15 #355

Limited Benefit of Biochemical Response to Combination Therapy with Interferon and Ribavirin for Patients with Recurrent Hepatitis C After Living-Donor Liver Transplantation Yoshihide Ueda*, Yasutsugu Takada, Hironori Haga, Motoshige Nabeshima, Hiroyuki Marusawa, Takashi Ito, Hiroto Egawa, Koichi Tanaka, Shinji Uemoto, Tsutomu Chiba

4:30 #356

Cost-Effectiveness of Screening for Recurrent Hepatocellular Carcinoma (HCC) After Liver Transplant (LT) Uri Ladabaum, Shan L. Cheng*, Francis Y. Yao, John P. Roberts

4:45 #357

Polymorphisms in the Angiotensin Converting Enzyme and Endothelin-1 Genes Are Not Risk Factors for Chronic Renal Failure Following Liver Transplantation Alan Moss*, Brynn Harrop, Volker Gurtler, Paul J. Gow, Peter Angus

5:00 #358

Ascites Improves Upon Serum Sodium and MELD for Predicting Mortality in Patients with Advanced Liver Disease Ma Somsouk*, Scott W. Biggins, Eric Vittinghoff, John M. Inadomi

5:15 #359

Liver Stiffness Assessment By TRANSIENT ELASTOGRAPHY in Patients After Living Donor Liver Transplantation Ryota Masuzaki*, Noriyo Yamashiki, Yasuhiko Sugawara, Ryosuke Tateishi, Haruhiko Yoshida, Sumihito Tamura, Hiroshi Imamura, Junichi Kaneko, Norihiro Kokudo, Masatoshi Makuuchi, Masao Omata

AASLD Research Forum 4:00 PM - 5:30 PM

7A San Diego Convention Center

4:45 #363

Selective Targeting of CTGF SIRNA to Activated Stellate Cells Reduces Carbon Tetrachloride (Ccl4) Induced Hepatic Fibrosis In Vivo Carmel Lawrencia*, David Brigstock

5:00 #364

High Molecular Weight Adiponectin Inhibits Proliferation of Hepatic Stellate Cells Via Activation of AMP-Activated Protein Kinase (AMPK) Masayuki Adachi*, Ekihiro Seki, Toshifumi Hibi, David A. Brenner

5:15 #365

The Bh3-Only Protein Noxa Mediates Hepatic Stellate Cell Apoptosis By Proteasome Inhibition Ivette M. Sosa Seda*, Justin L. Mott, Fernando J. Barreyro, Yuko Akazawa, Alisan Kahraman, Steven F. Bronk, Nathan W. Werneburg, Gregory J. Gores

AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM 9 San Diego Convention Center Chairs: Gregory G. Ginsberg, Glenn M. Eisen Sponsored by: Imaging & Advanced Technology

IMAGING AND ADVANCED TECHNOLOGY Participants will be able to: • Identify new information and recent advances in imaging technology. 4:00 #366

4:15 #367

4:00 #360

Deficiency of Tissue Transglutaminase Promotes Fibrogenesis and Does Not Facilitate Hepatic Fibrosis Reversal Yury Popov*, Jessica Zaks, Deanna Sverdlov, Gerry Melino, Tobias Freitag, Detlef Schuppan

4:15 #361

Natural Killer T Cell Activation Promotes a Fibrinolytic Phenotype Within the Cholestatic Liver Ian N. Hines*, Michael Kremer, Gakuhei Son, Richard J. Milton, Richard A. Rippe

4:30 #362

Phagocytic and Non-Phagocytic NADPH-Oxidase Isoforms Differentially Regulate Fibrosis But Not Steatosis in the Liver Samuele De Minicis*, Ekihiro Seki, Christoph Oesterreicher, Yuzo Kodama, Johannes Kluwe, Robert F. Schwabe, David A. Brenner

A Prospective Randomized Back-to-Back Trial Comparing Narrow Band Imaging to Conventional Colonoscopy for Adenoma Detection Seth A. Gross*, Anna M. Buchner, John R. Cangemi, Herbert C. Wolfsen, Kenneth R. DeVault, Julia Crook, Michael F. Picco, David S. Loeb, Timothy A. Woodward, Massimo Raimondo, Michael B. Wallace

4:30 #368

Functional Magnetic Resonance Imaging of the Pelvic Floor: Dynamic Pressure and Morphological Changes in the Levator Ani Muscle On Straining Demonstrated By MR-Assisted Biomechanical Modelling Emile Tan*, Su-Lin Lee, Wadyslaw Gedroyc, Julie A. Cornish, Ara Darzi, Guang-Zhong Yang, Vikram Khullar, Paris P. Tekkis

4:45 #369

Optical Noninvasive Imaging Using Multiphoton Microscopy Distinguishes Neoplasia from Inflammation in Human Colonic Tissue Eric C. Chu*, Ryan S. Lim, Andrzej Tarnawski, Bruce J. Tromberg

5:00 #370

In Vivo Molecular Imaging of Colorectal Cancer By Confocal Endomicroscopy Martin Goetz*, Alex Ziebart, Michael Vieth, Peter M. Delaney, Peter R. Galle, Markus F. Neurath, Ralf Kiesslich

5:15 #371

ePill: A New Wireless Capsule with Enhanced Diagnostic and Therapeutic Potential Peter J. van der Schaar*, Frits Dijksman, Anke Pierik, Judith Rensen, Jeff Shimizu

Chairs: Natalie Torok, Gregory J. Gores STELLATE CELL BIOLOGY AND HEPATIC FIBROGENESIS

Endoscopic Ultrasound Elastography in the Differential Diagnosis of Pancreatic Solid Masses: Towards the Virtual Biopsy Julio Iglesias-Garcia*, Jose Larino-Noia, Enrique Dominguez-Munoz

P-69

M O N D A Y MAY 19

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM 31BC San Diego Convention Center

AGA Institute Research Forum 4:00 PM - 5:30 PM

Chairs: Emeran A. Mayer, Gianrico Farrugia

Chairs: F. Fred Poordad, Robert S. Brown

Sponsored by: Neurogastroenterology and Motility

Sponsored by: Liver & Biliary

NEUROGASTROENTEROLOGY AND MOTILITY

CLINICAL HEPATITIS: DIAGNOSIS AND MANAGEMENT

Participants will be able to: • Learn about psychological contributions to functional motility disorders.

Participants will be able to: • Discuss the latest findings about treatment of clinical hepatitis; • Learn about liver disease progression and celiac disease in a hepatitis infected patient; and • Learn strategies for treatment of chronic hepatitis, including hepatitis B (HBV).

4:00 #372

M O N D A Y MAY 19

Silencing of Gene Expression for CorticotropinReleasing Factor (CRF) in the Colon Attenuates StressInduced Acceleration of Colonic Transit in Rats Sumei Liu*, Mei-Hu Qu, Wei Ren, Aditi Bhargava, Jen Chang, Julia J. Hoy, Guo-Du Wang, Fie Zou, Xiyu Wang, Xiaohong Sun, Yun Xia, Jackie D. Wood

4:15 #373

Regulation of Small Intestinal EC Cell Serotonin Release - the Role of Taste and Mechanical Forces Mark Kidd*, Bjorn I. Gustafsson, Ignat Drozdov, Oyvind Hauso, Irvin M. Modlin

4:30 #374

Effect of a Novel Trans-Galactooligosaccharide Prebiotic On Faecal Microbiota and Symptoms in Patients with Irritable Bowel Syndrome David B. Silk*, Amanda J. Davis, Jelena Vulevic, Glenn Gibson, George Tzortzis

4:45 #375

Role of Ghrelin in the Relation Between Hyperphagia and Accelerated Gastric Emptying in Mice with Streptozotocin-Induced Diabetes Pieter-Jan Verhulst*, Betty De Smet, Inge Y. Saels, Theo Thijs, Dieder Moechars, Luc Ver Donck, Theo L. Peeters, Inge Depoortere

5:00 #376

AZD3355, a Novel GABAB Receptor Agonist, Inhibits Transient Lower Esophageal Sphincter Relaxations in the Dog Anders Lehmann*, Lena Brändén, Anita Carlsson, Thomas Elebring, Jörgen Jensen, Jan P. Mattsson, Karolina A. Nilsson, Anna Uvebrant, Sverker von Unge

5:15 #377

P-70

A Randomized, Double-Blind, Placebo-Controlled Trial with a Novel Dual Noradrenergic Reuptake Inhibitor (NARI) and 5-HT3 Antagonist: Results of a Phase II 8Week Study in Female Patients with Diarrhea Predominant Irritable Bowel Syndrome (D-IBS) William G. Paterson, Jonathon Springer, Michael O'Mahony, Richard P. Reynolds, Subhas C. Ganguli, Brian Feagan, Suhail Nurbhai, Steven B. Landau*

30D San Diego Convention Center

4:00 #378

Liver Disease Progression in Chronic Hepatitis B Infected Persons with Normal Serum Alanine Amino Transferase Level: Update from the R.E.V.E.A.L.-HBV Study Jin-De Chen*, Hwai-I Yang, Uchenna H. Iloeje, San-Lin You, Sheng-Nan Lu, Li-Yu Wang, Jun Su, Chien-An Sun, Pei-Jer Chen, Yun-Fan Liaw, Chien-Jen Chen

4:15 #379

Long-Term Treatment with Lamivudine Up to Ten Years: Predictive Value of Host and Virus Related Risk Factors for the Development of HBV Resistance Florian van Bömmel*, Annika Brodzinski, Ulrike Mihm, Maria-Christina Jung, Christoph Sarrazin, Alexandra Bergk, Beate Schlosser, Morgane Chauvel, Michael Biermer, Tobias Mueller, Eckart Schott, Bertram Wiedenmann, Thomas Berg

4:30 #380

Project ECHO (Extension for Community Healthcare Outcomes): Knowledge Networks Expand Access to Hepatitis C (HCV) Treatment with Pegylated Interferon and Ribavirin in Rural Areas and Prisons. Care Is As Safe and Effective As a University HCV Clinic Sanjeev Arora*, Glen H. Murata, Karla Thornton, Brooke Parish, Steven M. Jenkusky, Jeffrey C. Dunkelberg, Richard M. Hoffman, Miriam Komaromy

4:45 #381

A Multicenter Analysis of Antiviral Response After One Year of Tenofovir Mono-Therapy in HBV-Monoinfected Patients with Prior Nucleos(t)ide Analog Experience Florian van Bömmel*, Robert A. De Man, Kerstin Stein, Dietrich Hüppe, Christoph Sarrazin, Jörg Trojan, Peter Buggisch, Joerg Petersen, Marcus Schuchmann, Ulrich Spengler, Hermann Wasmuth, Jurrien G. Reijnders, Andreas Erhardt, Heinz H. Feucht, Holger Hinrichsen, Bertram Wiedenmann, Thomas Berg

5:00 #382

Curative Effect of a Manufactured HIP/PAP Protein Against Fulminant Hepatitis Laurence Cam, Nicolas Moniaux, Claudia Mitchell, Didier Samuel, Gilles Amouyal, Paul Amouyal, Christian Bréchot, Jamila Faivre*

5:15 #383

Hepatitis C Virus (HCV) Flares in Patients with Hematological Malignancies Treated with Anti-CD 20 Antibody (Rituximab)-Including Regimens Manuela Mangone, Stefano Angeletti, Michela Di Fonzo, Fabio Attilia, Sara Gallina, Marcella Epifani, Bruno Monarca, Antonella Ferrari, Caterina Tatarelli, Gianfranco Delle Fave, Massimo Marignani*

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 4:00 PM - 5:30 PM

26B San Diego Convention Center

AGA Institute Research Forum 4:00 PM - 5:30 PM

28ABC San Diego Convention Center

Chairs: B. M. Evers, Lee W. Slice

Chairs: Severine Vermeire, Iris Dotan

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

HORMONES AND RECEPTORS: WHAT'S NEW IN INTRACELLULAR SIGNALING

IMIBD SEROLOGIC AND GENETIC MARKERS TO PREDICT THE CLINICAL COURSE OF INFLAMMATORY BOWEL DISEASE

Participants will be able to: • Become familiar with recent advances in intracellular signaling; and • Learn about signaling pathways controlling hormone secretion. 4:00 #384

ERK1c, a Novel Spliced Form of ERK1, Positively Regulates PGE2-Stimulated NT Secretion in the Human Endocrine Cell Line, BON Jing Li*, Tianyan Gao, Courtney M. Townsend, B. M. Evers

4:15 #385

Extracellular Calcium-Sensing Receptor (CaSR) Mediated Production of DKK-1 and Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Inhibits Defective Wnt Signaling Ivan I. Pacheco*, R. John MacLeod

4:30 #386

Endothelin Converting Enzyme-1 (ECE-1) Degrades Substance P (SP) in Endosomes and Regulates Mitogenic Signaling of the Neurokinin 1 Receptor (NK1R) Graeme S. Cottrell*, Benjamin E. Padilla, Jane E. Murphy, Nigel W. Bunnett

4:45 #387

Endosomal Deubiquitinating Enzymes (DUBS) Control Ubiquitination and Post-Endocytic Sorting of ProteaseActivated Receptor 2 (PAR2) Burcu Hasdemir*, Graeme S. Cottrell, Nigel W. Bunnett

5:00 #388

Molecular Mechanisms Responsible for Cross-Inhibition Between Nicotinic Acetylcholine Receptors and P2X Receptors Dima Alkawwas*, James Galligan

5:15 #389

Participants will be able to: • Be familiar with the use of anti-glycan antibodies to predict the prognosis of IBD; • Be familiar with the role of the ATG16l1 gene in the onset of pediatric IBD; and • Be familiar with the role of anti-hTM5 antibody in ulcerative colitis. 4:00 #390

The Novel Anti-Glycan Antibodies Anti-L and Anti-C in Conjunction with ALCA, ACCA, gASCA and AMCA Predict Early Development of Fistulae, Stenoses and Surgery in Patients with Crohn's Disease: A Prospective Analysis Florian Rieder*, Alexandra Wolf, Stephan Schleder, Andrea Dirmeier, Ulrike Strauch, Florian Obermeier, Larissa Spector, Ella Fire, Jennifer Yarden, Gerhard Rogler, Nir Dotan, Frank Klebl

4:15 #391

Two Novel Polysaccharide Antibodies (Anti-Laminarin and Anti-Chitin) Predict An Aggressive Crohn's Disease Phenotype and Improve Differentiation Between Crohn's Disease and Ulcerative Colitis Cynthia H. Seow*, Joanne M. Stempak, Wei Xu, Hui Lan, Anne M. Griffiths, Gordon R. Greenberg, A. Hillary Steinhart, Nir Dotan, Mark S. Silverberg

4:30 #392

Specific Levels and Combinations of the Anti-Glycan Antibodies Anti-L, Anti-C, ALCA, ACCA, gASCA and AMCA Contribute to Diagnosis and Differential Diagnosis of Patients with Crohn's Disease and Are Associated with Complicated Disease and Surgery Florian Rieder*, Stephan Schleder, Alexandra Wolf, Andrea Dirmeier, Ulrike Strauch, Florian Obermeier, Larissa Spector, Ella Fire, Jennifer Yarden, Gerhard Rogler, Nir Dotan, Frank Klebl

HVPS34, the Class III PI3K, Is Involved in cAMPStimulated Neurotensin Secretion in the Human Endocrine Cell Line BON Jing Li*, Tianyan Gao, Courtney M. Townsend, B. M. Evers 4:45 #393

The Contribution of Germline Variation in the Autophagy Genes ATG16l1 and Irgm to Childhood Onset Inflammatory Bowel Disease Johan Van Limbergen*, Richard K. Russell, Elaine R. Nimmo, Hazel E. Drummond, Linda Smith, Niall H. Anderson, Gail Davies, Peter M. Gillett, Paraic McGrogan, Lawrence Weaver, Michael W. Bisset, Gamal Mahdi, Ian D. Arnott, David C. Wilson, Jack Satsangi

5:00 #394

Age of Diagnosis Influences Serologic Responses in Children with Crohn Disease: A Possible Clue to Etiology? James Markowitz*, Subra Kugathasan, Marla C. Dubinsky, Mei Ling, Wallace Crandall, Neal S. LeLeiko, Maria OlivaHemker, Joel R. Rosh, Jonathan Evans, David R. Mack, Anthony R. Otley, Marian D. Pfefferkorn, Ron J. Bahar, Eric A. Vasiliauskas, Ghassan Wahbeh, Gary Silber, J. Antonio Quiros, Iwona T. Wrobel, Justin Nebel, Carol J. Landers, Yoana Picornell, Kent D. Taylor, Jerome I. Rotter, Stephan R. Targan, Jeffrey S. Hyams

5:15 #395

Anti-hTM5 Antibody in Autologous Sera of Ulcerative Colitis Destroys Colonic Epithelial Cells By Antibody and Complement-Mediated Lysis Ellen C. Ebert*, Kiron M. Das

P-71

M O N D A Y MAY 19

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 4:00 PM - 5:30 PM

33BC San Diego Convention Center

30B San Diego Convention Center

Chairs: Lars Eckmann, Gerhard Rogler

Chairs: Massimo Raimondo, Andres Gelrud

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

Sponsored by: Pancreatic Disorders

INTRACELLULAR SIGNALING IN INTESTINAL INFLAMMATION AND DYSPLASIA Participants will be able to: • Understand the intracellular signaling that regulates dysplasia in experimental colitis and IBD; • Understand how estrogen regulates cytokine expression; and • Understand how Wnt and beta catenine regulate dysplasia.

M O N D A Y

AGA Institute Research Forum 4:00 PM - 5:30 PM

4:00 #396

Estrogen Suppresses Mucosal Cytokine Responses to Microbial Ligands Mirjam Looijer-van Langen*, Levinus A. Dieleman, Hugo Diaz, Brendan Diederichs, Karen Madsen

4:15 #397

Colonic STE20-Related Protein Kinase Isoform (SPAK): A Novel Regulator of Intestinal Inflammation Yutao Yan*, Guillaume Dalmasso, Laetitia CharrierHisamuddin, Hang Thi Thu Nguyen, Shanthi V. Sitaraman, Didier Merlin

4:30 #398

Phosphatidylinositol 3-Kinase (PI3K)-Mediated Phosphorylation of β-Catenin Is Required for Progression of Colitis-Induced Dysplasia in IL-10 Ko Mice Goo Lee*, Guang-Yu Yang, Meghan Barrett, Kaitlin Wanta, Linheng Li, Terrence A. Barrett

4:45 #399

MAY 19

Nuclear Phosphorylated-β-Catenin Staining Is Increased in Human Ulcerative Colitis and Colitis-Induced Dysplasia Patricia K. Sun*, Goo Lee, Elizabeth Managlia, Badar Muneer, Ishfaq Bhat, Guang-Yu Yang, Xi C. He, Linheng Li, Terrence A. Barrett

5:00 #400

Enhanced Expression from Non Immune Cells of Wnt5a in Ulcerative Colitis Is Associated with Disease Activity and Neoplastic Transformation Andrea Buda*, Renata D'Incà, Daniela Pizzuti, Alessia R. Grillo, Davide Checchin, Laura Nai, Ignazio Castagliuolo, Massimo Rugge, Massimo Pignatelli, Giacomo C. Sturniolo

5:15 #401

The Atypical Chemokine Receptor D6 Controls Intestinal Inflammation and Inflammation-Associated Colon Cancer Stefania Vetrano, Elena Borroni, Raffaella Bonecchi, Carmen Correale, Vincenzo Arena, Massimo C. Fantini, Alberto Malesci, Annunciata Vecchi, Alberto Mantovani, Massimo Locati, Silvio Danese*

P-72

IPMN AND CYSTIC NEOPLASMS OF THE PANCREAS Participants will be able to: • Describe new developments in the diagnostic approach to indeterminant pancreatic cysts; and • Recognize advances in understanding of the natural history and malignant potential of IPMN. 4:00 #402

Branch-Duct Intraductal Papillary Mucinous Neoplasms: Single Center Experience in 190 Patients Sang Myung Woo*, Ji Kon Ryu, Ki Young Yang, Jeong Kyun Seo, Joo Kyung Park, Sang Hyub Lee, Won Jae Yoon, YongTae Kim, Yong Bum Yoon

4:15 #403

Branch Duct Type-Intraductal Papillary Mucinous Neoplasm (BDT-IPMN) of the Pancreas: Does Immunosuppression (IS) Change the Natural History? Kanwar R. Gill*, Mario Pelaez-Luna, Andrew Keaveny, Timothy A. Woodward, Michael B. Wallace, Suresh T. Chari, Thomas C. Smyrk, Naoki Takahashi, Jonathan E. Clain, Michael J. Levy, Randall K. Pearson, Bret T. Petersen, Mark D. Topazian, Santhi Swaroop Vege, Michael L. Kendrick, Michael B. Farnell, Massimo Raimondo

4:30 #404

Acute Pancreatitis (AP) in Patients with Intraductal Papillary Mucinous Neoplasms of the Pancreas (IPMN): Frequency, Severity and Correlation with Tumors Characteristics Anne-Laure Pelletier*, Pascal Hammel, Vinciane Rebours, Marie-Pierre Vullierme, Anne Couvelard, Alain Aubert, Frédérique Maire, Olivia Hentic, Dermot O'Toole, Alain Sauvanet, Philippe Lévy, Philippe B. Ruszniewski

4:45 #405

Characteristics of Intraductal Papillary Mucinous Neoplasm and Cyst of the Pancreas That Develop An Infiltrating Ductal Adenocarcinoma During Follow-Up Minoru Tada*, Takao Kawabe, Saburo Matsubara, Yoko Yashima, Toshihiko Arizumi, Osamu Togawa, Yousuke Nakai, Naoki Sasahira, Kenji Hirano, Takeshi Tsujino, Hiroyuki Isayama, Masao Omata

5:00 #406

DNA Mutational Analysis Versus Cytology with and Without Fluid CEA Level in the Diagnosis of Mucinous Cystic Lesions of the Pancreas: A Multicenter Study. Eugene Zolotarevsky, Mayar Al Mohajer, Richard S. Kwon, Andres Gelrud, Nonthalee Pausawasdi, Nathan Schmulewitz, Grace H. Elta, Michelle A. Anderson*

5:15 #407

Comparison of K-RAS-2 and LOH Mutational Analysis with Pancreas Cyst Fluid CEA Levels and Histology Jayaprakash Sreenarasimhaiah*, Saad F. Jazrawi, Luis F. Lara, Shou Jiang Tang

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 4:00 PM - 5:30 PM

30C San Diego Convention Center

Chairs: Charles A. Parkos, Jerrold R. Turner Sponsored by: Intestinal Disorders

MODELING THE PATHOPHYSIOLOGY OF INTESTINAL DISORDERS Participants will be able to: • Learn about modeling the pathophysiology of intestinal disorders. 4:00 #408

TNF-α Inhibits Human Intestinal NHE8 Gene Expression in Caco2 Cells Via Tyrosine Kinase Pathway Hua Xu*, Huacong Chen, Jiali Dong, Fayez K. Ghishan

4:15 #410

Regulation of the Human Anion Exchanger SLC26A3 Gene Expression By IFNγ Seema Saksena*, Amika Singla, Shivani Katyal, Nikhil Bansal, Waddah A. Alrefai, Krishnamurthy Ramaswamy, Pradeep K. Dudeja

4:30 #411

4:45 #412

PI3K, AKT and MAPK Differentially Mediate Mitogenic and Motogenic Effects of Repetitive Deformation On Intestinal Epithelial Cells Christopher Gayer*, Lakshmi S. Chaturvedi, Marc D. Basson Pathogenic Roles of COX-2/PGs and iNOS/NO in a Rat Model of Ischemic Enteritis Tohru Kotani*, Yoshino Komatsu, Yuka Nakamori, Koji Takeuchi

5:00 #413

Obestatin and Ghrelin Attenuate Intestinal IschemiaReperfusion Injury Via Both Central and Peripheral Mechanisms Leyla Semiha Sen*, Berna Karakoyun, Mustafa Akkiprik, Meral Yuksel, Ilker Parmaksiz, Feriha Ercan, Ayse S. Ozer, Cumhur Yegen, Berrak C. Yegen

5:15 #414

γ-Irradiation Upregulates NHE2 in Mice Small Intestine Anju T. Nayar, Kunzhong Zhang, Hengshan Zhang, Paul Okunieff, Lurong Zhang, Sadasivan Vidyasagar*

AGA Institute Research Forum 4:00 PM - 5:30 PM

8 San Diego Convention Center

Chairs: Mae F. Go, Richard M. Peek Sponsored by: Esophageal, Gastric & Duodenal Disorders

4:30 #417

Normal Circular Muscle But Dysfunctional Longitudinal Muscle in Eosinophilic Esophagitis Hariprasad R. Korsapati*, Ranjan Dohil, Alissa M. Quin, Valmik Bhargava, Ravinder K. Mittal

4:45 #418

H. pylori Stimulated Conventional Dendritic Cells Retained Toleragenicity of Immature Dendritic Cells While Upregulating Proinflammatory Cytokines Min Zhang, Bradford E. Berndt, Brian M. Gray, John Y. Kao*

5:00 #419

Proinflammatory Cytokines Reduce the Viability of Gastric Chief Cells By Disrupting Tight Junction Structure and Function During Helicobacter pylori Infection Songhua Zhang*, Kimihito Tashima, JiHye Seo, Regina Ragasa, James G. Fox, Susan J. Hagen

5:15 Sp484

Defining New Mechanisms of Inflammation in the UGI Tract Jean Marie Houghton

AGA Institute Topic Forum 4:00 PM - 5:30 PM

Chairs: John M. Inadomi, Amnon Sonnenberg Sponsored by: Clinical Practice; Gastrointestinal Oncology

IMPORTANT CLINICAL ISSUES REGARDING POLYPS AND COLORECTAL CANCER Participants will be able to: • Review the latest data on the development of colorectal cancer after colonoscopy; • Identify important risk factors for the development of colorectal cancer; and • Discuss important new insights regarding the identification of serrated adenomas. 4:00 #420

Statin Use and Risk of Colorectal Cancer: A Population Based Case Control Study Douglas J. Robertson*, Anders Riis, Søren Friis, Lars Pedersen, John A. Baron, Henrik T. Sørensen

4:15 #421

Oral Contraceptive Use, Hormone Replacement Therapy and Rectal Cancer: A Population Based Case-Control Study Millie Long*, Christopher Martin, Robert Sandler

4:30 #422

Don't Judge a Polyp By Its Appearance: Clinical and Endoscopic Features of a Large Series of Sessile Serrated Adenomas Nnenna Okpara*, Harlan G. Rich, Edmond Sabo, baishali bhattacharya

4:45 #423

Computer-Aided Texture Analysis of the Colonic Polyp Surface Visualized By Endoscopy As a Novel Method for Distinguishing Sessile Serrated Adenomas from Other Histologic Types Edmond Sabo*, Nnenna Okpara, Harlan G. Rich, Baishali Bhattacharya, Murray B. Resnick

5:00 #424

The Characteristics of Small and Diminutive Colorectal Polyps As Seen On Conventional Colonoscopy Sheetal Sharma*, Ashar Ata, Seth Richter

5:15 #425

Predictors of Flat Adenomas: Results of Screening Using a High Resolution Colonoscope in a Diverse Population Joseph C. Anderson*, Benjamin Stein, Charles J. Kahi, Ramona Rajapakse, Zvi A. Alpern

NOVEL INSIGHTS INTO UGI INFLAMMATORY PATHOGENESIS: FOCUS ON YOUNG INVESTIGATORS Participants will be able to: • Learn about new progress in esophageal and gastric inflammatory processes: focus on EoE and HP. 4:00 #415

4:15 #416

High-Dose Acid Suppression Distinguishes Severe Reflux Esophagitis from Eosinophilic Esophagitis Wael N. Sayej*, Raza A. Patel, Robert D. Baker, Eduardo D. Tron, Anita M. Crawley, Susan S. Baker Eosinophilic Esophagitis Is Associated with Active and Uniform Secretion of Th-2 Cytokines and Reduced Esophageal Smooth Muscle Contractility Ilche T. Nonevski*, Gary W. Falk, Edgar Achkar, John R. Goldblum, Florian Rieder, Tracey L. Bonfield, Piero Biancani, Claudio Fiocchi

6DE San Diego Convention Center

P-73

M O N D A Y MAY 19

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 4:00 PM - 5:30 PM

30E San Diego Convention Center

4:36 #435

Decline of Incidence and Mortality of Peptic Ulcer Bleeding Between 1983-85 and 2002-04: A PopulationBased Study in the Treviso Area (North-East Italy) Silvano Loperfido, Vincenzo Baldo, Elena Piovesana*, Ludovica Bellina, Katia Rossi, Marzia Groppo, Stefano Realdon, Alessandro Caroli, Nadia Dal Bò, Fabio Monica, Luca Fabris, Helena Heras Salvat, Nicolò Bassi, Lajos Okolicsanyi

4:48 #436

Analysis of Cause of Death in Peptic Ulcer Bleeding Patients: Study of a Cohort of 10,451 Cases Joseph J. Sung*, Man Yee Yung, Terry K. Ma, Kelvin K. Tsoi, James Y. Lau, Philip W. Chiu

5:00 #437

Early Endoscopy in Nonvariceal Upper GI Hemorrhage: Prevalence and Outcome in a Population-Based Sample Gregory S. Cooper*, Tzuyung D. Kou, Richard C. Wong

5:12 Sp485

State-of-the-Art Lecture: Timing of Endoscopy and Outcomes in Upper GI Bleeding Joseph J.Y. Sung

Chairs: Tushar Patel, Toshifumi Hibi Sponsored by: Gastrointestinal Oncology; Pancreatic Disorders; Liver & Biliary

MICRO RNA AND EXPRESSION PROFILES IN GASTROINTESTINAL CANCERS Participants will be able to: • Become familiar with micro RNA and expression profiles in gastrointestinal cancers.

M O N D A Y

4:00 #426

Overexpression of MicroRNA-142 and -155 in API2MALT1-Positive Gastric Low-Grade MALT Lymphoma Hidekazu Suzuki*, Yoshimasa Saito, Toshihiro Nishizawa, Eisuke Iwasaki, Hiroyuki Imaeda, Toshifumi Hibi

4:15 #427

Activation of Alu-Associated Micrornas By Epigenetic Therapy of Human Gastric Cancer Cells Yoshimasa Saito*, Hidekazu Suzuki, Toshifumi Hibi

4:30 #428

Possible Roles of Let-7 MicroRNA Expression in the Cytotoxin-Associated Gene A (cagA) Associated Pathogenesis Jun Wang*, Masahiko Tsujii, Shingo Tsuji, Toru Nakamura, Hiroshi Eguchi, Shusaku Tsutsui, Hideki Iijima, Tsutomu Nishida, Yoshimi Kakiuchi, Satoshi Egawa, Kenji Watabe, Shuji Ishii, Shinichiro Shinzaki, Sachiko Nakajima, Toshiyuki Yoshio, Jumpei Kondo, Yujiro Hayashi, Sunao Kawano, Norio Hayashi

4:45 #429

MicroRNA Control of COX-2 Expression Lisa E. Young, Ashleigh E. Moore, Dan A. Dixon*

5:00 #430

Micro RNA (miR-17-5p) Is Overexpressed in Pancreatic Cancer, and Upregulation of miR-17-5p Enhanced Cancer Cell Proliferation and Invasion In Vitro Jun Yu*, Taiki Moriyama, Kenoki Ohuchida, Lin Cui, Norihiro Sato, Masafumi Nakamura, Shunichi Takahata, Eishi Nagai, Kazuhiro Mizumoto, Masao Tanaka

5:15 #431

A Novel MicroRNA Panel Accurately Diagnoses Cholangiocarcinoma Using Nearest Shrunken Centroids Florin M. Selaru*, Alexandru Olaru, Kwisa Kang, Zhe Jin, Anirban Maitra, Michael S. Torbenson, Jian Yang, Yulan Cheng, Yuriko Mori, James P. Hamilton, Bogdan C. Paun, Tetsuo Ito, Stefan David, Rachana Agarwal, John M. Abraham, Douglas M. Jefferson, Gregory J. Gores, Nicholas F. LaRusso, Stephen J. Meltzer

MAY 19

ASGE Topic Forum 4:00 PM - 5:30 PM

11 San Diego Convention Center

Chairs: Joo Ha Hwang, Lisa L. Strate GASTROINTESTINAL BLEEDING 4:00 #432

Prospective Evaluation of the Upper and Lower Gastrointestinal Tract in Young Patients with Iron Deficiency Anemia Bani Chander*, Edmund J. Bini

4:12 #433

Localization, Efficacy of Therapy, and Outcomes of Dieulafoy Lesions of the GI Tract - The UT Southwestern GI Bleed Team Experience Luis F. Lara*, Jayaprakash Sreenarasimhaiah, Shou Jiang Tang, Bianca B. Afonso, Don C. Rockey

4:24 #434

Retrospective Observational Study of Patients Admitted with Acute Upper GI Bleed Khurum H. Khan*, Steven R. Kinnear, Grant Caddy

P-74

ASGE Topic Forum 4:00 PM - 5:30 PM

5 San Diego Convention Center

Chairs: Philip S. Schoenfeld, David I. Weinberg NEW TECHNIQUES TO ENHANCE POLYP DETECTION 4:00 #438

A Randomized Controlled Study Comparing CapAssisted Colonoscopy Versus Conventional Colonoscopy: The Final Result Yuk-tong Lee, Larry Lai*, Aric Hui, Vincent W. Wong, Jessica Ching, James Y. Lau, Wai K. Leung, Henry Lik-Yuen Chan, Justin Wu, Francis K. L. Chan, Joseph J. Sung

4:12 #439

A Comparison of Overall Adenoma Detection and Recovery Rate of Optical Colonoscopy and CT Colonography Mark E. Benson*, Parul Dureja, Deepak V. Gopal, Mark Reichelderfer, David H. Kim, Perry J. Pickhardt, Andrew J. Taylor, Patrick R. Pfau

4:24 #440

Fellow Participation Increases Adenoma Detection Rate During Colonoscopy Jason N. Rogart*, Uzma D. Siddiqui, Priya A. Jamidar, Harry R. Aslanian

4:36 #441

Usefulness of a Transparent Retractable Extension Device On Colorectal Adenoma Detection Akira Horiuchi*, Yoshiko Nakayama

4:48 #442

Colonoscopy in Obese Patients: A Growing Problem Michael P. Desormeaux*, Mary Scicluna, Shai Friedland

5:00 Sp486

State-of-the-Art Lecture: Enhancing Polyp Detection David A. Lieberman

ASGE Topic Forum 4:00 PM - 5:30 PM

6C San Diego Convention Center

Chairs: Gottumukkala S. Raju, Christopher C. Thompson NEW TECHNOLOGY 4:00 #443

A Randomised Comparative Study Between Dilation By Electrocautery Incision and Savary Bougies for Benign Anastomotic Gastro-Esophageal Strictures Marjan L. Hordijk*, Jeanin E. Hooft van, Bettina E. Hansen, Paul Fockens, E. J. Kuipers

ORAL SESSIONS—SCIENTIFIC SESSIONS 4:12 #444

Endoscopic Incisional Therapy with Iso-Tome and Transparent Hood in Patients with Benign Anastomotic Esophageal Stricture Tae Hoon Lee*, Suck-Ho Lee, Ji-Young Park, Jeong Hoon Park, Do Hyun Park, Il Kwun Chung, Hong-Soo Kim, Sang-Heum Park, Sun-Joo Kim, Su Jin Hong, Moon Sung Lee

4:24 #445

Randomized Controlled Study of Endoscopic Mucosal Resection (EMR) Versus Endoscopic Submucosal Dissection with a Waterjet Hybridknife (ESDH) of Esophageal Lesions in a Porcine Model Horst Neuhaus*, Katja Wirths, Markus D. Enderle, Brigitte Schumacher

4:36 #446

A New Transoral Gastroplasty Device for GERD and Obesity Rudolf J. Stadlhuber*, Fumiaki Yano, Sumeet K. Mittal, Raul J. Rosenthal, Richard I. Rothstein, Charles J. Filipi

4:48 #447

A Novel Device, Countertraction-Spring, Is Easier and Safer for Endoscopic Submucosal Dissection of Mucosal Stomach Cancer Nobuyuki Sakurazawa*, Masao Miyashita, Shunji Kato, Teruo Kiyama, Tsutomu Nomura, Itsuro Fujita, Takeshi Okuda, Keiichi Okawa, Hideyuki Takata, Yoshinori Sakata, Goro Takahashi, Natsuki Seki, Katsuhiko Iwakiri, Takashi Tajiri

5:00 #448

Magnetic Force Assisted Endoscopic Submucosal Dissection with Permalloy Tissue Anchors Kazuki Sumiyama*, Takeshi Ohdaira, Keiichi Ikeda, Hisao Tajiri

5:12 Sp487

State-of-the-Art Lecture: Endosurgery: A Paradigm Shift Kenneth F. Binmoeller

AGA Institute Business Meeting 5:30 PM - 6:30 PM

AGA Institute Business Meeting 5:30 PM - 6:30 PM

4 San Diego Convention Center

Chairs: Deborah C. Rubin, Alan L. Buchman Sponsored by: Nutrition & Obesity

NUTRITION AND OBESITY SECTION BUSINESS MEETING

M O N D A Y

8 San Diego Convention Center

MAY 19

Chairs: Mae F. Go, Richard M. Peek Sponsored by: Esophageal, Gastric & Duodenal Disorders

ESOPHAGEAL, GASTRIC & DUODENAL DISORDERS SECTION BUSINESS MEETING AGA Institute Business Meeting 5:30 PM - 6:30 PM

9 San Diego Convention Center

Chairs: Gregory G. Ginsberg, Glenn M. Eisen Sponsored by: Imaging & Advanced Technology

IMAGING & ADVANCED TECHNOLOGY SECTION BUSINESS MEETING AGA Institute Business Meeting 5:30 PM - 6:30 PM

31BC San Diego Convention Center

Chairs: Emeran A. Mayer, Gianrico Farrugia Sponsored by: Neurogastroenterology and Motility

NEUROGASTROENTEROLOGY AND MOTILITY SECTION BUSINESS MEETING

P-75

ORAL SESSIONS—SCIENTIFIC SESSIONS SCIENTIFIC SESSIONS 8:37 #453

Video: Totally Laparoscopic Extended Right Hepatectomy Andrew A. Gumbs*, Brice Gayet

8:54 #454

Standardization of Laparoscopic Distal Pancreatic Resection (LapDPR) with Regional Lymphadenectomy in Malignant Pancreatic Neoplasms (MPN) Laureano Fernández-Cruz

9:10 #455

Laparoscopic Sigmoid Resection for Complicated Diverticulitis (Colovaginal Fistula) Barry Salky

Marriott Hotel & Marina

9:27 #456

ERCP: How to Avoid Disasters and Optimize Success (BC07) Torrance (South Tower) Peter B. Cotton

Laparoscopic Celiac Artery Decompression Khashayar Vaziri*, Edward Auyang, Nathaniel J. Soper, Eric S. Hungness

9:44 #457

Pneumatosis Coli: Resection of the Splenic Flexure with Intracorporeal Anastomosis Melina C. Vassiliou*, Douglas S. Smink, Gina L. Adrales

ASGE Breakfast with Champions 6:30 AM - 8:00 AM

Sp491

Colonoscopy: Who, When, How and Why (BC05) David A. Lieberman Coronado (South Tower)

Marriott Hotel & Marina Sp488

Sp489

Endoscopic Ultrasound (EUS): Staging and Diagnostic Roles (BC06) Kenneth J. Chang Rancho Las Palmas (South Tower)

Marriott Hotel & Marina Sp490

ERCP: Taking On the Pancreas (BC08) Stuart Sherman

Mission Hills Marriott Hotel & Marina

AGA Institute Sunrise Discussion 7:00 AM - 8:00 AM 30B San Diego Convention Center

AGA Institute Committee Sponsored Symposium 8:00 AM - 12:00 PM 33A San Diego Convention Center Chair: Carl L. Berg Sponsored by: Education & Training Committee

Chairs: Pradeep K. Dudeja, Meena Rao ABIM MAINTENANCE OF CERTIFICATION MADE EASY Sponsored by: Intestinal Disorders

ADVANCES IN EPITHELIAL TRANSPORT Participants will be able to: • Review advances in epithelial transport presented at DDW 2008. 7:00 Sp492

Advances in Epithelial Transport Pradeep K. Dudeja, Meena Rao

SSAT Video Session 7:30 AM - 10:00 AM

T U E S D A Y MAY 20

25 San Diego Convention Center

Chairs: Craig P. Fischer, Attila Nakeeb

Participants will be able to: • Learn the process involved in ABIM maintenance of certification (MOC) in GI including PIMS and self-evaluation of medical knowledge modules; • Complete ABIM gastroenterology self-evaluation module Recent Advances (24R) for credit towards ABIM MOC; and • Discuss new AGA Institute tools to facilitate MOC. 8:00 Sp494

GI SEP Module Completion Carl L. Berg

9:20 Sp495

GI SEP Module Completion C. Prakash Gyawali

10:40 Sp496

GI SEP Module Completion Jane Onken

SSAT VIDEO SESSION II: BREAKFAST AT THE MOVIES Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas. 7:30 #449

Combined Treatment of Esophageal Perforation: A New Approach Bryan J. Sandler*, Michelle K. Savu, Garth R. Jacobsen, John Cullen, Thomas J. Savides, Mark A. Talamini, Santiago Horgan

7:47 #450

Dual Incision Adjustable Gastric Band Placement Garth R. Jacobsen*, Bryan J. Sandler, John Cullen, Mark A. Talamini, Adam Spivack, Santiago Horgan

8:04 #451

A Simplified Technique for Placement of Biologic Mesh in Paraesophageal Hernia Repair (PEH) Tayyab S. Diwan*, Danny V. Martinec, Michael Ujiki, Christy M. Dunst, Lee L. Swanstrom

8:20 #452

P-76

Human NOTES Hybrid Transgastric Cholecystectomy Edward Auyang*, Khashayar Vaziri, John A. Martin, Eric S. Hungness, Nathaniel J. Soper

AGA Institute State-of-the-Art-Lecture 8:30 AM - 9:30 AM 3 San Diego Convention Center Chairs: Marc S. Levin, David A. Rudnick Sponsored by: Growth, Development & Aging; Liver & Biliary

PROTEOMIC APPROACHES FOR INVESTIGATION OF AUTOIMMUNE DISEASES Participants will be able to: • Understand the role of proteomics in diagnosing human disease; • Appreciate the challenges and opportunities of analyzing the proteome in humans with autoimmune disease; and • Learn about advances of proteomics in inflammatory bowel disease. 8:30 Sp496a

Proteomic Approaches for Investigation of Autoimmune Diseases Paul J. Utz

ORAL SESSIONS—SCIENTIFIC SESSIONS DDW Combined Clinical Symposium 8:30 AM - 10:00 AM 20BCD San Diego Convention Center Chairs: Ira M. Jacobson, Robert J. Fontana Sponsored by: AASLD; AGA Institute

HEPATITIS B 8:30 Sp497

Epidemiology and Natural History of HBV Ray Kim

8:50 Sp498

Current and Controversial Indications for Treatment in 2008 Ira M. Jacobson

9:10 Sp499

Detection, Prevention, and Management of Drug Resistant HBV Norah Terrault

9:30

Case #1

9:45

Case #2

AGA Institute Clinical Symposium 8:30 AM - 10:00 AM 6A San Diego Convention Center

AGA Institute Clinical Symposium 8:30 AM - 10:00 AM 6DE San Diego Convention Center Chairs: Adam Slivka, Kapil B. Chopra Sponsored by: Liver & Biliary; Pancreatic Disorders; Gastrointestinal Oncology; Clinical Practice

PRIMARY SCLEROSING CHOLANGITIS (PSC): PATHOGENESIS, DIAGNOSIS AND MANAGEMENT Participants will be able to: • Learn about the pathogenesis of primary sclerosing cholangitis (PSC); • Learn about the diagnosis and management of primary sclerosing cholangitis (PSC); and • Learn about the role of liver transplantation in primary sclerosing cholangitis (PSC). 8:30 Sp504

Controversy of Liver Transplantation in PSC - Emerging Role of Living Related Liver Transplantation Amadeo Marcos

9:00 Sp505

PSC and Cholangiocarcinoma - Outcomes After Liver Transplantation - the Role of Neo-Adjuvant Chemotherapy Gregory J. Gores

9:30 Sp506

Autoimmunity in Sclerosing Cholangitis; Associations of PSC with Autoimmune Pancreatitis (AIP) and Autoimmune Liver Disease Kazuichi Okazaki

Chairs: Richard J. Saad, Kevin W. Olden Sponsored by: Clinical Practice; Neurogastroenterology and Motility; Immunology, Microbiology & Inflammatory Bowel Disease; Esophageal, Gastric & Duodenal Disorders; Nutrition & Obesity; Intestinal Disorders

AN EVIDENCE BASED APPROACH TO CONTROVERSIES IN IBS MANAGEMENT Participants will be able to: • Review RCT data on efficacy/safety of prebiotics, probiotics, and antibiotics in IBS patients; • Review RCT data on efficacy/safety of SSRIs and TCAs in IBS patients; and • Review RCT data on efficacy/safety of tegaserod/alosetron in IBS patients and review RCT data on efficacy/safety of CAM in IBS patients. 8:30 Sp500

Gut Flora & Colonic Mucosal Inflammation: Do Prebiotics, Probiotics or Antibiotics Improve IBS Symptoms? Philip S. Schoenfeld

8:53 Sp501

The Brain-Gut Interaction: Do SSRIs and TCAs Improve IBS Symptoms? Lin Chang

9:16 Sp502

Maximizing the Benefit-Risk Equation: When Should You Use Alosetron and Tegaserod? Amy E. Foxx-Orenstein

9:38 Sp503

Diet, Active Food, and Complementary Medicines: Physiological Benefits or Placebo Effects? Yehuda Ringel, Kevin W. Olden

AGA Institute Clinical Symposium 8:30 AM - 10:00 AM 29 San Diego Convention Center Chairs: Peter A. Banks, Michael G. Sarr Sponsored by: Pancreatic Disorders; Imaging & Advanced Technology; Clinical Practice; Nutrition & Obesity

SEVERE ACUTE PANCREATITIS: REVISING THE ATLANTA CLASSIFICATION AND UPDATE ON MANAGEMENT Participants will be able to: • Discuss the strengths and limitations of clinical scoring systems for severe acute pancreatitis; and • Recognize and manage complications associated with necrotizing acute pancreatitis. 8:30 Sp507

Severe Acute Pancreatitis: 2008 Colin D. Johnson

8:48 Sp508

Panel Discussion: Challenges in Managing Necrotizing Pancreatitis Peter A. Banks, Santhi Swaroop Vege, Michael G. Sarr, Richard A. Kozarek

AGA Institute Committee Sponsored Symposium 8:30 AM - 10:00 AM 30D San Diego Convention Center Chair: Henry J. Binder Sponsored by: International Committee

BEST OF UEGW Participants will be able to: • Summarize and provide selected highlights of the October 2007 UEGW meeting in Paris, France. 8:30 Sp512

Liver Disease Tania Roskams

P-77

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS 8:48 Sp513

Small Intestinal Diseases Chris Mulder

9:06 Sp514

GI Oncology Jaroslaw Regula

9:24 Sp515

Endoscopy and Pancreas Markus M. Lerch

9:42 Sp516

IBD Daniel W. Hommes

AGA Institute Committee Sponsored Symposium 8:30 AM - 10:00 AM 26A San Diego Convention Center Chair: Barbara H. Jung Sponsored by: Ethics Committee; Publications Committee

CONFLICT OF INTEREST IN PUBLICATIONS - WHOSE ISSUE IS IT ANYWAY? Participants will be able to: • Identify the nature of conflict of interest in clinical publications; • Learn how researchers can minimize and journals currently address potential conflicts of interest; and • Participate and discuss avenues for journals to avoid conflicts of interest in the future. 8:30 Sp517

What Is the Problem? Gordon Guyatt

8:45 Sp518

The Editor's View I Anil K. Rustgi

9:00 Sp519

The Editor's View II: Why Is There No Code of Ethics for Journal Editors? Ajit Varki

9:15 Sp520

How to Avoid Conflict of Interest As a Researcher R. Balfour Sartor

9:30

T U E S D A Y MAY 20

Q&A

AGA Institute Research Symposium 8:30 AM - 10:00 AM 33BC San Diego Convention Center Chairs: Andrew T. Gewirtz, Lora V. Hooper Sponsored by: Intestinal Disorders; Neurogastroenterology and Motility; Esophageal, Gastric & Duodenal Disorders; Immunology, Microbiology & Inflammatory Bowel Disease; Clinical Practice; Growth, Development & Aging

BACTERIAL ROLES IN INTESTINAL DISORDERS Participants will be able to: • Gain a general overview of the roles of the intestinal microflora in diverse human diseases, including obesity, inflammatory bowel disease, and immune deficiency; • Identify the roles of the intestinal microflora in promoting human health and define the molecular mechanisms that underlie interactions between the intestinal microflora and the host; and • Describe the state of the art approaches used to analyze interactions between the intestinal microflora and the host. 8:30 Sp522

The Role of Microflora in Immune System Development Sarkis K. Mazmanian

9:00 Sp523

Inflammatory Bowel Disease As a Communicable Infectious Disease Wendy S. Garrett

9:30 Sp524

TLR-Mediated Responses to, and Control of, Enteric Microbes Andrew T. Gewirtz

AGA Institute Translational Symposium 8:30 AM - 10:00 AM 28DE San Diego Convention Center Chairs: Thomas R. Ziegler, Stephen A. McClave Sponsored by: Nutrition & Obesity; Pancreatic Disorders; Clinical Practice; Hormones, Transmitters, Growth Factors, & Their Receptors

AGA Institute Morton I. Grossman Lectureship 8:30 AM - 10:00 AM 31BC San Diego Convention Center

MICRONUTRIENT SUPPLEMENTATION AND CLINICAL OUTCOMES IN CRITICAL ILLNESS

THE GROSSMAN LECTURE: 'STEMNESS' DOES NOT EXPLAIN ALL THE WAYS IN WHICH TISSUES ARE HEALED BY ADULT STEM/PROGENITOR CELLS (MSCS)

Participants will be able to: • List the clinical outcomes resulting from micronutrient supplementation in critical illness; and • Define the clinical role of arginine, glutamine, and selenium.

Participants will be able to: • Identify the different ways tissues may be healed by MSCs. 8:30 Sp521

P-78

'Stemness' Does Not Explain All the Ways in Which Tissues Are Healed By Adult Stem/Progenitor Cells (MSCs) Darwin J. Prockop

8:30 Sp525

Role of Arginine Luc Cynober

9:00 Sp526

Role of Glutamine Thomas R. Ziegler

9:30 Sp527

Role of Selenium Alan Shenkin

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Translational Symposium 8:30 AM - 10:00 AM 20A San Diego Convention Center Chairs: Stephan R. Targan, Morten H. Vatn Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease; Intestinal Disorders; Growth, Development & Aging ; Clinical Practice; Neurogastroenterology and Motility

WHAT CAUSES IBD? Participants will be able to: • Become familiar with the debate on issues relating genetics and environmental conditions as potential causes for IBD. 8:30 Sp528

Is It the Genes? Miles Parkes

9:15 Sp529

Is It the Environment? Charles N. Bernstein

ASGE Clinical Symposium 8:30 AM - 10:00 AM

1 San Diego Convention Center

Chairs: Gregory G. Ginsberg, Christian Ell MANAGEMENT OF THE PATIENT WITH EARLY ESOPHAGEAL CANCER: IS THE WORLD FLAT? 8:30 Sp530

The European Approach Oliver Pech

8:50 Sp531

The Asian Approach Hironori Yamamoto

9:10 Sp532

The American Approach Kenneth K. Wang

9:30

SSAT Conference/Debate/Panel/Symposium 8:30 AM - 10:00 AM 28ABC San Diego Convention Center Chair: Lygia Stewart SSAT PUBLIC POLICY COMMITTEE PANEL: THE EFFECTS OF QUALITY INITIATIVES AND REPORTING ON PATIENT CARE AND REIMBURSEMENTS TO PHYSICIANS AND HOSPITALS Participants will be able to: • Understand the effects of pay for performance and quality reporting initiatives on reimbursements to physicians and hospitals; • Recognize the potential effects of quality initiatives on patient care; and • Understand the intentions of the centers for medicare and medicaid services by instituting pay for performance and physician quality reporting initiatives. 8:30 Sp538

Measuring Quality, and the Effects On the Quality of Care Clifford Y. Ko

8:45 Sp539

Payment Reform: The Impact of CMS Value Based Payment Policies On Your Practice and Your Patients Susan Nedza

9:00 Sp540

How Are Quality Initiatives and Public Reporting Affecting Hospitals? Andrea Snyder

9:15 Sp541

Improving the Quality of Surgical Care Throughout a Region: The SCOAP Initiative of Washington State Carlos A. Pellegrini

9:30

Panel and Audience Discussion

AASLD Plenary Session 8:30 AM - 10:00 AM

Questions & Answers

7B San Diego Convention Center

Chairs: Sandy Feng, Nizar N. Zein

ASGE Clinical Symposium 8:30 AM - 10:00 AM

6C San Diego Convention Center

Chairs: Robert H. Hawes, Anthony N. Kalloo

PRESIDENTIAL PLENARY III 8:30 #458

Randomized, Double-Blinded, Placebo Controlled MultiCenter Trial of Etanercept in the Treatment of Alcoholic Hepatitis Nicholas C. Boetticher*, Craig J. Peine, Paul Kwo, Gary A. Abrams, Tushar Patel, Bashar Aqel, Gregory J. Gores, Craig J. McClain, Patrick S. Kamath, William S. Harmsen, Vijay Shah

8:45 #459

IL-2 Receptor Antagonist (Il2-RA) ,Basiliximab, Is Associated with Rapid Fibrosis Progression in Patients with Recurrent Hepatitis C Virus (HCV) After Liver Transplantation (LT) Using Serial Biopsy Specimens Ibrahim A. Hanouneh*, Nizar N. Zein, Rocio Lopez, Lisa M. Yerian, John J. Fung, Bijan Eghtesad

NOTES™: AN UPDATE 8:30 Sp533

How Will Gastroenterologists Get to Do NOTES™ Sergey V. Kantsevoy

8:45 Sp534

NOTES™ Technology Development Update: Hot Off the Press! Christopher C. Thompson

9:00 Sp535

Robotics and NOTES™ - A Good Marriage or Just Hype? Dmitry Oleynikov

9:15 Sp536

The International Human Experience with NOTES™: From Europe to Latin America Jacques Marescaux

9:30 Sp537

The Trickle Down Affect - How NOTES™ Will Advance Therapeutic Endoscopy Pankaj J. Pasricha

9:45

9:00 #460

The 13c Methacetin Breath Test Accurately Identifies Liver Fibrosis in Patients with Chronic Hepatitis C Virus Infection: A Validation Study Gadi Lalazar*, Orit Pappo, Rifaat Safadi, Yaffa Ashur, Beat Mullhaupt, Oliver Goetze, Yaron Ilan

9:15 #461

Combination Antiviral Therapy Differentially Affects Dendritic Cell Chemokine Receptor and Maturation Marker Expression in Chronic Hepatitis C Infection John A. Mengshol*, Lucy Golden-Mason, Nicole Castelblanco, KyungAh Im, Hugo R. Rosen

9:30 #462

Nonalcoholic Fatty Liver Disease (NAFLD) Occurring Post-Transplant - Risk Factors and Outcome Kanthi Yalamanchili*, Sherif N. Saadeh, Don C. Rockey

Questions & Answers

P-79

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS 9:45 #463

Dobutamine Stress Echocardiography (Dse) Is a Poor Predictor of Coronary Artery Disease in Patients Undergoing Liver Transplant Evaluation Lynn Shapiro*, Maximilian Lee, Jason Lee, Parvathi A. Myer, Ahmad Kamal, Aijaz Ahmed

AASLD Research Forum 8:30 AM - 10:00 AM

7A San Diego Convention Center

9:06 #472

Randomized Controlled Trial of Esophageal Capsule Endoscopy Versus Standard Endoscopy for Screening in Patients Pre-Liver Transplantation. Assessment of InterObserver Variability and Patient Preferences Lauren B. Gerson*, Ahmad Kamal, Nighat Ullah, Aijaz Ahmed

9:24 #473

Autofluorescence Assessment in the Surveillance of Barrett's Oesophagus: A Randomised Trial Comparing Standard 4 Quadrant Biopsy and AF Directed Biopsy Audrey L. McCallum*, Mairi Macpherson, John T. Jenkins, Peter S. Chong, Derek Gillen, Fraser Duthie, Karin Oien, Grant M. Fullarton

9:42 #474

An Implantable, Wireless and Batteryless Impedance Sensor Capsule for Detecting Acidic and Non-Acidic Reflux Thermpon Ativanichayaphong, Shou Jiang Tang, Jianqun Wang, Wen-Ding Huang, Harry F. Tibbals, Stuart J. Spechler, Jung-Chih Chiao*

Chairs: Wajahat Z. Mehal, Grace L. Su CELL DEATH AND EXPERIMENTAL HEPATOTOXICITY 8:30 #464

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-Induced Liver Injury Mie Shinohara*, Naoko Hanawa, Behnam Saberi, Maria D. Ybanez, William A. Gaarde, Derick Han, Neil Kaplowitz

8:45 #465

Deletion of Apoptosis Signal-Regulating Kinase 1 (Ask1) Attenuates Acetaminophen-Induced Liver Injury By Inhibiting Prolonged JNK Activation Hayato Nakagawa*, Shin Maeda, Kei Sakamoto, Yoku Hayakawa, Keiji Ogura, Masao Omata

9:00 #466

Anti-Apoptotic Effect of Jnk1 Through Mcl-1 Stabilization in TNFα-Induced Hepatocyte Apoptosis Yuzo Kodama*, Kojiro Taura, Kouichi Miura, Yosuke Osawa, David A. Brenner

9:15 #467

T U E S D A Y MAY 20

Aspirin Blocks Acetaminophen Induced Hepatotoxicity and Mortality in Mice - Dependent On the ASC/Caspase1 Inflammasome Avlin B. Imaeda*, Fayyaz Sutterwala, Azuma Watanabe, Shamail Mahmood, Muhammad A. Sohail, Richard A. Flavell, Wajahat Z. Mehal

9:30 #468

Cts-1027, a Broad-Spectrum Matrix Metalloprotease Inhibitor, Attenuates Liver Injury and Fibrosis in the Bile Duct-Ligated Mouse Alisan Kahraman*, Steven F. Bronk, Sophie Cazanave, Nathan W. Werneburg, Justin L. Mott, Patricia Contreras, Gregory J. Gores

9:45 #469

In Vivo Confocal Imaging of Apoptosis of the Liver Martin Goetz*, Jacqueline Ansems, Marcus Schuchmann, Peter M. Delaney, Peter R. Galle, Markus F. Neurath, Ralf Kiesslich

AGA Institute Research Forum 8:30 AM - 10:00 AM

30B San Diego Convention Center

Chairs: Glenn M. Eisen, Kenneth R. DeVault Sponsored by: Imaging & Advanced Technology

ADVANCES IN ESOPHAGEAL IMAGING Participants will be able to: • Become familiar with advances in esophageal imaging. 8:30 #470

Targeted Detection of High-Grade Dysplasia in Barrett's Esophagus with Fluorescent-Labeled Peptides Shaoying Lu, Anson W. Lowe, George Triadafilopoulos, James M. Crawford, Thomas D. Wang*

8:48 #471

The Learning Curve of In Vivo Confocal Laser Endomicroscopy for Prediction of Barrett's Esophagus Kerry B. Dunbar*, Elizabeth A. Montgomery, Marcia I. Canto

P-80

AGA Institute Research Forum 8:30 AM - 10:00 AM

30E San Diego Convention Center

Chairs: Hamid I. Akbarali, Adam J. Rich Sponsored by: Neurogastroenterology and Motility

CONTROL OF SMOOTH MUSCLE FUNCTION Participants will be able to: • Understand the role of smooth muscle in gastrointestinal motility. 8:30 #475

Role of L-Type Calcium Channels, Membrane Potential and Nitric Oxide in the Control of Myogenic Activity in the Primate Internal Anal Sphincter Naomi Harvey*, Bronagh McDonnell, Melanie McKechnie, Kathleen Keef

8:45 #476

VIP Prevents Smooth Muscle Dysfunction in Colonic Inflammation By Blocking the Activation of Transcription Factor Nf-κB Xuan-Zheng P. Shi*, Barun K. Choudhury, Sushil K. Sarna

9:00 #477

Effect of Sexual Hormones On Cholinergic and Adrenergic Contractile Mechanisms of Colonic Smooth Muscle Strips in An In Vitro Model of Naïve Female Rats Bruno M. Balsiger*, Thomas Hubacher, Christine Baumgartner, Luis A. Tovar, Christian Knusel, Beatrice Flogerzi, Andreas Rickenbacher, Manfred Essig, Ulrich Scheurer, Juergen M. Gschossmann

9:15 #478

Myosin II Is a Novel Co-Activator of ICAM-1 Gene Transcription By TNFα Qingjie Li*, Sushil K. Sarna

9:30 #479

Impaired Enteric Circular Muscle Activity in the Cystic Fibrosis Mouse Small Intestine: Role of Prostaglandin E2 Robert C. De Lisle*, Lauren Meldi

9:45 #480

Tempol Improves Impaired Gallbladder Contractility in An Experimental Model of Cholecystitis Pedro J. Gomez-Pinilla*, Pedro Camello, Maria J. Pozo

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 8:30 AM - 10:00 AM

26B San Diego Convention Center

8:45 #488

Protein Level and Gene Promoter Polymorphism of Matrilysin (Mmp-7) Are Independent Prognostic Factors for Survival of Colorectal Cancer Patients Alexandra Langers*, Hein W. Verspaget, Lukas Hawinkels, Daniel W. Hommes, Cornelis B. Lamers, Cornelis F. Sier

9:00 #489

IL-1β-511c Allele Is Associated with Increased Risk of Colonic Adenomas in Obesity Michael Dorfman*, Frank Martiniuk, Maryann Huie, Guillermo I. Perez-Perez, Fritz Francois

9:15 #490

Loss of IGF2 Genomic Imprinting and Cancer Risk in An Ethnically Diverse Population Marcia R. Cruz-Correa*, Ronghua Zhao, Mariana Berho, Steven Wexner, Dana Sands, Juan Nogueras, Eric G. Weiss, Francis M. Giardiello

9:30 #491

The Influences of Genetic Polymorphisms of Interleukin-17a and -17f Genes On the Gastric Carcinogenesis in Japan Tomiyasu Arisawa*, Tomomitsu Tahara, Tomoyuki Shibata, Masakatsu Nakamura, MItsuo Nagasaka, Yoshio Kamiya, Hiroshi Fujita, Daisuke Yoshioka, Masaaki Okubo, Yuko Arima, Hiroaki Shimazaki, Ichiro Hirata, Hiroshi Nakano

9:45 #492

High Prevalence of Gastric Cancer in Families with Germline TP53 Mutations Serena Masciari, Akriti Dewanwala*, Elena M. Stoffel, Frederick Li, Judy E. Garber, Sapna Syngal

Chairs: Jose Maria Remes Troche, Hiroshi Mashimo Sponsored by: Neurogastroenterology and Motility

FECAL INCONTINENCE, PELVIC FLOOR DISORDERS AND OTHER ANORECTAL DISORDERS Participants will be able to: • Better understand anorectal function in health and disease; • Learn about treatment options for anorectal disorders; and • Learn about fecal incontinence. 8:30 #481

Cytokinesis Blocked Micronucleus (Cbmn) Assay Is Predictive of Gastrointestinal (GI) Sequeale 2 Years Following Radiation Therapy (RT) for Prostate Carcinoma (Cap) Whilst Micronutrients Reduce Their Severity Eric Yeoh*, Addolorata C. Di Matteo, Rochelle J. Botten, Julie Butters, Varinderpal Dhillon, Richard H. Holloway, Ian Olver, Michael Fenech

8:45 #482

Assessment of Anatomy and Function of the Puborectalis and Anal Sphincter Muscles in Asymptomatic Parous Women Milena M. Weinstein*, Dolores H. Pretorius, Sung-Ae Jung, Jennifer J. Wan, Charles W. Nager, Ravinder K. Mittal

9:00 #483

Relative Contribution of Age and Parity On the Female Anorectum in Symptomatic Patients Derek J. Boyle*, Chetan Bhan, Jamie Murphy, Charles H. Knowles, Mark Scott, Peter J. Lunniss, Norman S. Williams

9:15 #484

Prevalence of Fecal Incontinence (Fi) and Urinary Incontinence (Ui) After Bariatric Surgery Erica N. Roberson*, Jon C. Gould, Wade A. Bushman, Arnold Wald

9:30 #485

Twelve-Month Follow-Up of Randomized Controlled Trial (RCT) Comparing Biofeedback to Alternative Treatments for Patients with Pelvic Floor DyssynergiaType Constipation (PFD) Steve Heymen*, Yolanda V. Scarlett, William E. Whitehead

9:45 #486

Pelvic Neuromodulation Controls Colonic Motility, Defecation and Induces Miction. Evaluation of a SPIDER-System Jacek Sobocki*, Michal Nowakowski, Roman M. Herman, Piotr Walega, John Spensley

AGA Institute Research Forum 8:30 AM - 10:00 AM

AGA Institute Research Forum 8:30 AM - 10:00 AM

Chairs: Julian Panes, Geert D’Haens Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IMIBD ANTI-TNF THERAPY FOR IBD I. Participants will be able to: • Be familiar with the effect of anti-TNF therapy on the antibody response to pneumococcal vaccine; • Be familiar with the long-term safety of certolizumab pegol; and • Be familiar with the use of infliximab for the treatment of pouchitis. 8:30 #493

Safety Profile and Signal of Efficacy of a Non-FcrBinding, Fully Human Anti-Cd3 Monoclonal Antibody in Patients with Moderate to Severe Crohn's DiseaseResults of a Phase I/Iia, Double Blind, PlaceboControlled, Randomized, Dose Escalation Study Christien J. van der Woude*, Pieter C. Stokkers, Ad A. van Bodegraven, Gert A. Van Assche, Zbigniew Hebzda, Leszek Paradowski, Geert D'Haens, Subrata Ghosh, Brian Feagan, Paul J. Rutgeerts, Gerard Dijkstra, Dirk J. De Jong, Bas Oldenburg, Mahdi Farhan, Yann Dean, Daniel W. Hommes

8:45 #494

Efficacy and Safety of Certolizumab Pegol in Patients with Active Crohn's Disease Who Previously Lost Response or Were Intolerant to Infliximab: Open-Label Induction Preliminary Results of the Welcome Study Severine Vermeire, Maria T. Abreu, Geert D'Haens, JeanFrédéric Colombel, Krassimir Mitchev, Richard Fedorak, Andreas Raedler, William J. Sandborn, Paul J. Rutgeerts*

9:00 #495

TNF Blockers and Immunomodulators Impair Antibody Responses to Pneumococcal Polysaccharide Vaccine (Ppv) in Patients with Inflammatory Bowel Disease (IBD) Gil Y. Melmed*, Robert Frenck, Cristina Barolet-Garcia, Patricio Ibanez, Peter Simpson, Konstantinos A. Papadakis, Joel Ward, Andrew Ippoliti, Stephan R. Targan, Eric A. Vasiliauskas

31A San Diego Convention Center

Chairs: Andrew T. Chan, Temitope O Keku Sponsored by: Gastrointestinal Oncology

GENETIC SUSCEPTIBILITY, POLYMORPHISMS AND BIOMARKERS IN GASTROINTESTINAL CANCERS Participants will be able to: • Evaluate genetic susceptibility, polymorphisms and biomarkers in gastrointestinal cancers. 8:30 #487

Gene Expression Profiles for Prognosis Provide a Novel Approach for Selection of Individualized Therapies in Early Stage Colon Carcinoma Katherine S. Garman*, Marian Grade, Chaitanya Acharya, Kelli S. Walters, Shivani Sud, David Hsu, Joseph R. Nevins, Thomas Ried, Anil Potti

6B San Diego Convention Center

P-81

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS 9:15 #496

Long-Term Safety of An Anti-TNF Drug By Duration of Exposure Compared to Non-Anti-TNF Exposed Patients with Crohn's Disease: Novel Data from the Certolizumab Pegol Development Program Gary R. Lichtenstein*, Jean-Frédéric Colombel, Ralph Bloomfield, William J. Sandborn

9:30 #497

Efficacy of Infliximab in Refractory Pouchitis and CDRelated Complications of the Pouch: A Belgian Case Series Marc Ferrante*, Geert D'Haens, Olivier Dewit, Filip J. Baert, Karel Geboes, Gert A. Van Assche, Séverine Vermeire, Paul Rutgeerts

9:45 #498

Adalimumab Trough Serum Levels and Clinical Response in a Single-Center Cohort of Inflammatory Bowel Disease Patients: Can Trough Serum Levels Serve As a Predictor for Future Loss of Response? Konstantinos Karmiris*, Gilles Paintaud, Danielle Degenne, Marc Ferrante, Anne-Claire Duveau, Maja Noman, Gert A. Van Assche, Severine Vermeire, Paul Rutgeerts

AGA Institute Research Forum 8:30 AM - 10:00 AM

6F San Diego Convention Center

Chairs: James D. Lewis, Edouard Louis Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IMIBD ISSUES IN IBD II. Participants will be able to: • Be familiar with the effect of maternal infliximab on neonatal immune response; • Be familiar with the use of quantiferon (whole blood gamma interferon assay) for the diagnosis of latent tuberculosis; and • Be familiar with the efficacy of azathioprine after surgery for Crohn's disease.

T U E S D A Y

8:30 #499

The Effect of Maternal Peripartum Infliximab Use On Neonatal Immune Response Uma Mahadevan*, Sunanda V. Kane, Joseph a. Church, Eric A. Vasiliauskas, William J. Sandborn, Marla C. Dubinsky

8:45 #500

Inherent Differences in 6mp Transport in Human Lymphocytes: Correlation with Drug-Induced Cytotoxicity Laurie S. Conklin*, Carmen Cuffari, Bahman Saatian, Maria Oliva-Hemker, Steven R. Brant, Philip Alex, Xuhang Li

8:45 #501

Discrepant Results Between Routine Screening for Latent Tuberculosis (Tb) and Quantiferon® in Patients with Inflammatory Bowel Diseases (IBD) Pavol Papay*, Alexander Eser, Petra Paulinska, Cornelia Lichtenberger, Andrea Mikulits, Wolfgang Miehsler, Clemens Dejaco, Gottfried Novacek, Harald Vogelsang, Walter Reinisch

9:00 #502

Thiopurine Metabolite Measurements During Pregnancy in Mother and Child Bindia Jharap*, Nanne de Boer, Christien J. van der Woude, Daniel W. Hommes, Pieter C. Stokkers, Dirk J. De Jong, Bas Oldenburg, Gerard Dijkstra, Ruurd M. van Elburg, Ad A. van Bodegraven

9:15 #503

Alteration of Thiopurinephosphate Metabolite Levels By Aminosalicylates in IBD-Patients Peer d. Graaf*, Nanne de Boer, Bindia Jharap, Chris J. Mulder, Ad A. van Bodegraven, Matthias Schwab

MAY 20

P-82

9:30 #504

A Double-Blind, Double-Dummy, Randomized, Controlled, Multicenter Trial On the Efficacy and Safety of Azathioprine Vs mesalamine for Prevention of Clinical Relapses in Crohn's Disease Patients with Postoperative Moderate or Severe Endoscopic Recurrence Walter Reinisch*, Sieglinde Angelberger, Wolfgang Petritsch, Klaus Herrlinger, Olga Shonova, Milan Lukas, Simon BarMeir, Matthias Schwab, Roland Greinwald, Ralph Mueller, Eduard Stange

AGA Institute Research Forum 8:30 AM - 10:00 AM

30A San Diego Convention Center

Chairs: Laurent Ferrier, Suzana D. Savkovic Sponsored by: Intestinal Disorders

INTESTINAL INJURY AND REPAIR Participants will be able to: • Become familiar with intestinal injury and repair. 8:30 #505

Reorganization of Cytoskeleton As Basis for Apoptosis Yaohong Wang*, Sudeep P. George, Kamalakkannan Srinivasan, Mohammad R. Siddiqui, Sijo Mathew, Langzhu Tan, Lester Vanmiddlesworth, Qi Xi, Jonathan H. Jaggar, Seema Khurana

8:45 #506

L-Arginine Availability Is Essential for Colonic Epithelial Restitution Kshipra Singh*, Rupesh Chaturvedi, Roxanne J. Wadia, Mohammad Asim, Nuruddeen D. Lewis, Daniel P. Barry, Keith T. Wilson

9:00 #507

Parallel Roles for Human Beta-Defensin 2 (Hbd2) and the Inflammatory Chemokine CCL20 in Regulating Restitution of Model Intestinal Epithelium Rebecca A. Vongsa*, Michael B. Dwinell

9:15 #508

SMAD3 Knockout Mice Exhibit a Defect in Intestinal Mucosal Healing Cheri Owen, Lisi Yuan, Marc D. Basson*

9:30 #509

Roles of COX/PGs/EP4 Receptors in Healing of Indomethacin-Induced Small Intestinal Lesions in Rats: Relation to VEGF Expression Kohei Kamei*, Ryo Hatazawa, Yoshikazu Kubo, Mayu Tanigami, Koji Takeuchi

9:45 #510

Protective Role for HSF1 and Hsps Against Both Irritant-Induced Gastric Lesions and DSS-Induced Colitis, An Animal Model for Human IBD Ken-ichiro Tanaka, Tohru Mizushima*

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 8:30 AM - 10:00 AM

30C San Diego Convention Center

8:45 #518

Regulation of Colonic CD4+ T Cell Activation By Modification of Carbohydrate Assembly Kiyotaka Nagahama, Ken Sugimoto, Yasuyo Shimomura, Atsuhiro Ogawa, Akira Andoh, Taku Kobayashi, Nobuhiko Kamada, Tadakazu Hisamatsu, Toshifumi Hibi, Richard S. Blumberg, Atsushi Mizoguchi*

9:00 #519

Deletion of Ccr6 Aggravates Colitis in IL-10 Knockout Mice Sabine Westphal*, Oliver Syrieyx, Wolfram W. Domschke, Torsten F. Kucharzik, Andreas Luegering

9:15 #520

Recruitment of Cd103+ Dendritic Cells in Response to Helicobacter Hepaticus Infection Responsible for Induction of FOXP3+ Tregs in the Small Intestine Bayasi Guleng*, Seiji Arihiro, Sonal Gupta, Carmen Alonso, Hans-Christian Reinecker

9:30 #521

GM-CSF Signaling in Intestinal Epithelial Cells Regulates Ileal Barrier Function Xiaonan Han*, Ingrid Jurickova, Tara Willson, Charles M. Samson, Erin Bonkowski, Bruce Trapnell, Lee Denson

9:45 #522

Retinoic Acid Controlled Cyclooxygenase-2 Mediates Induction of Regulatory T-Cells in the Intestine Femke Broere, M. Fleur du Pré*, Lisette van Berkel, Bart Lambrecht, Rudolf W. Hendriks, Edward Nieuwenhuis, Georg Kraal, Janneke Samsom

Chairs: Ashok K. Saluja, Edwin C. Thrower Sponsored by: Pancreatic Disorders

MECHANISMS OF PANCREATITIS Participants will be able to: • Understand the current concepts underlying the pathogenesis of pancreatitis; • Understand the relationship between pancreatic injury and induction of pain; and • Understand the role of enzyme activation in pancreatitis. 8:30 #511

Heat Shock Protein 70 Protects Against Pancreatitis By Stabilizing Lysosomal Enzyme Containing Organelles in Acinar Cells Rupjyoti Talukdar*, Rajinder Dawra, Vikas Dudeja, Selwyn M. Vickers, Ashok K. Saluja

8:45 #512

The Transient Receptor Potential (Trp) Ion Channels TRPA1 and TRPV4 Mediate Inflammatory Pain in the Pancreas Eugene P. Ceppa*, Fiore Cattaruzza, Silvia Amadesi, Natalya Vaksman, Eileen Grady, Wolfgang Liedtke, Nigel W. Bunnett, Kimberly S. Kirkwood

9:00 #513

HLA-DR*405 Transgenic NOD Mice Develop Autoimmune Pancreatitis Tobias Freitag*, Candace Cham, Hsiang-Hsuan Sung, Roderick T. Bronson, Detlef Schuppan, Grete Sonderstrup

9:15 #514

Effect of Various Toll-Like Receptor Stimulation On the Development of Murine Autoimmune Pancreatitis Akiyoshi Nishio*, Masanori Asada, Takuji Akamatsu, Kazuyuki Saga, Junya Tanaka, Masahiro Kido, Norihiko Watanabe, Tsutomu Chiba

9:30 #515

Role of Bone Marrow-Derived Cells in Experimental Chronic Pancreatitis Frédéric Marrache, Zhigang Song*, Swaroop Pendyala, Govind Bhagat, Kelly S. Betz, Timothy C. Wang

9:45 #516

Proangiogenic Role of Pancreatic Stellate Cells Atsushi Masamune*, Takashi Watanabe, Kazuhiro Kikuta, Tooru Shimosegawa

AGA Institute Research Forum 8:30 AM - 10:00 AM

8 San Diego Convention Center

AGA Institute Research Forum 8:30 AM - 10:00 AM

Chairs: Roy C. Orlando, John M. Wo Sponsored by: Esophageal, Gastric & Duodenal Disorders

UPDATE ON GERD PATHOGENESIS Participants will be able to: • Learn about progress in GERD pathogenesis. 8:30 #523

The Gene Expression of PAR-2 and TRPV-1 Is Increased in Erosive and Non-Erosive GERD Arne Kandulski*, Thomas Wex, Klaus E. Monkemuller, Doerthe Kuester, Lucia C. Fry, Peter Malfertheiner

8:45 #524

Anatomy of Vagal Afferent Innervation of the Crural Diaphragm Richard L. Young*, Nicole J. Cooper, L. Ashley Blackshaw

9:00 #525

Real Time Pressure Morphology of Esophagogastric Junction (EGJ) Recorded Using a 128-Sensor HighDefinition Manometry Array Thomas B. Nealis*, Sudip K. Ghosh, Monika A. Kwiatek, John E. Pandolfino, Peter J. Kahrilas

9:15 #526

Dilated Intercellular Spaces (DIS) Are Associated with Released of Substance P After Exposure of Esophageal Mucosa to Bile Acids Ricard Farré*, Hannah van Malenstein, Rita de Vos, Pieter Vanden Berghe, Inge Depoortere, Jan F. Tack, Daniel Sifrim

9:30 #527

Natural History of NERD in the General Population, the Kalixanda study Jukka Ronkainen*, Pertti Aro, Tom Storskrubb, Nicholas J. Talley, Michael Vieth, Tore Lind, Lars Agreus

9:45 Sp542

State-of-the-Art Overview Session Chair

Chairs: Mamoru Watanabe, Ivan J. Fuss Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

T CELL REGULATION IN INTESTINAL INFLAMMATION Participants will be able to: • Understand how chemokines regulate intestinal inflammation; • Understand how GM-CSF signaling affects the epithelial barrier; and • Understand how TGFβ signaling regulates T cells. 8:30 #517

T Cell-Specific Smad7 Over-Expression Reduces Regulatory T Cell-Mediated Control of Colitis Massimo C. Fantini*, Angelamaria Rizzo, Daniele Fina, Massimiliano Sarra, Roberta Caruso, Christoph Becker, Francesco Pallone, Thomas T. Macdonald, Markus F. Neurath, Giovanni Monteleone

32AB San Diego Convention Center

P-83

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 8:30 AM - 10:00 AM

4 San Diego Convention Center

Chairs: Paul Moayyedi, Karna Dev Bardhan Sponsored by: Esophageal, Gastric & Duodenal Disorders

9:00 #535

Auto-Regulation of Human Tcf-4 By Wnt-β-Catenin-Tcf-4 Signaling Guoxing Wang*, Oliver Burk, Eduard Stange, Jan Wehkamp

9:15 #536

Haploinsufficiency of Krüppel-Like Factor 5 Inhibits Adenoma Formation in APCMin/+ Mice By Modulating βCatenin Activity Beth B. McConnell*, Agnieszka Bialkowska, Mandayam O. Nandan, Amr Ghaleb, Vincent W. Yang

9:30 #537

Reg IV Induces β-Catenin Nuclear Translocation to Induce Cell Proliferation in Human Colon Adenocarcinomas Kumar S. Bishnupuri*, Jennifer Gross, Mekala Sabarinathan, Qizhi Luo, Satheesh K. Sainathan, Konrad Aden, Courtney W. Houchen, Shrikant Anant, Brian K. Dieckgraefe

9:45 #538

CpG Island Methylation of Wnt Signalling Genes in Single Colonic Crypts Reveals a Non-Uniform Distribution of Gene-Silencing Amongst Crypts in the Mucosal Field Nandita Pal*, Michael P. Lewis, Mark R. Williams, Ian T. Johnson, Nigel J. Belshaw

UPPER GI PATHOLOGY: FROM H. PYLORI BACK TO ACID Participants will be able to: • Understand mechanisms involved in acid-peptic lesions of the upper GI tract. 8:30 #528

8:45 #529

Recurrence of Upper Gastrointestinal Bleed (UGIB) and the Effect of Acid-Suppressive Drugs Luis A. García Rodríguez*, Elvira L. Massó González

9:00 #530

Complicated and Uncomplicated Peptic Ulcer Disease: The Altered Symptom Response to the Nutrient Challenge Is Linked to Gastric Motor Function Montri Gururatsakul*, Max Bellon, Dylan Bartholomeusz, Richard H. Holloway, Nicholas J. Talley, Gerald J. Holtmann

9:15 #531

9:30 #532

9:45 Sp544

T U E S D A Y MAY 20

Long-Term Outcome of Helicobacter pylori-Negative Idiopathic Bleeding Ulcers: A 7-Year Prospective Cohort Study Grace Wong, Jessica Ching, Yawen Chan, Francis K. L. Chan*

Increased Risk of Esophageal Squamous Cell Carcinoma in Patients with Gastric Atrophy: Independent of the Severity of Atrophic Changes Annemarie C. de Vries*, Lisette G. Capelle, Caspar W. Looman, M. van Blankenstein, Nicole C. van Grieken, M. K. Casparie, Gerrit A. Meijer, Ernst J. Kuipers Incidence and Risk Factors for Development of Fundic Gland Polyps and Hyperplastic Polyps During LongTerm Proton Pump Inhibitor Therapy: A Prospective Multicenter Study in Japan Michio Hongo*, Kazuma Fujimoto, Yasuhiro Marukawa, Toshihisa Arai, Yukinori Sakata

AGA Institute Topic Forum 8:30 AM - 10:00 AM

Chairs: Steven J. Czinn, Takeshi Azuma Sponsored by: Esophageal, Gastric & Duodenal Disorders; Immunology, Microbiology & Inflammatory Bowel Disease

IMMUNOPATHOGENESIS OF H. PYLORI INFECTION Participants will be able to: • Recognize how H. pylori induces an aberrant host immune response that leads to pathogenesis. 8:30 #539

Inhibition of Polyamine Synthesis Attenuates Helicobacter pylori Colonization and Reduces Gastritis By Enhancing Host Nitric Oxide Production Rupesh Chaturvedi*, Kshipra Singh, Mohammad Asim, Nuruddeen D. Lewis, Daniel P. Barry, Robert A. Casero, Elizabeth I. Harris, Keith T. Wilson

8:45 #540

Vaccine-Induced Protective Immunity Against Helicobacter pylori Is IL-23 Dependent Hua Ding*, John Nedrud, Steven Czinn

9:00 #541

Polymorphisms in Genes That Code for the Innate Immune Response As a Risk Factor for Duodenal Ulcer Dulciene M. Queiroz*, Andreia Maria C. Rocha, Gifone A. Rocha, Luciana I. Gomes, Juliana B. Guerra, Fabricio F. Melo, Sílvia B. Moura, Celso A. Oliveira

9:15 #542

Helicobacter pylori Strains from a Region of High Gastric Cancer Risk Exhibit Increased Ability to Activate Inducible Nitric Oxide Synthase and Spermine Oxidase Mohammad Asim*, Rupesh Chaturvedi, M. Blanca Piazuelo, Kshipra Singh, Ivy Kuofie, Stephanie M. Cauble, Liviu A. Sicinschi, Judith Romero-Gallo, Luis E. Bravo, M. Constanza Camargo, Barbara G. Schneider, Pelayo Correa, Keith T. Wilson

9:30 #543

Expression of Fractalkine (CX3CL1) and Its Involvement in Helicobacter pylori Infection Deepa Raju*, Mauricio Terebiznik, Soumitra Tole, Lisa Robinson, Nicola L. Jones

9:45 #544

The Role of cagA Molecular Variations in Induction of Host Phenotypes with Carcinogenic Potential Natasha J. Schneider*, Uma S. Krishna, Judith RomeroGallo, M. Blanca Piazuelo, M. Constanza Camargo, Liviu A. Sicinschi, Barbara G. Schneider, Pelayo Correa, Richard M. Peek

State-of-the-Art Overview Grigoris I. Leontiadis

AGA Institute Research Forum 8:30 AM - 10:00 AM

9 San Diego Convention Center

Chairs: Jonathan P. Katz, Beth B. McConnell Sponsored by: Gastrointestinal Oncology

WNT/BETA-CATENIN PATHWAY IN GASTROINTESTINAL CANCERS Participants will be able to: • Become familiar with Wnt/beta-catenin pathway in GI cancers. 8:30 #533

Regulation of Sox9 and Wnt Signaling By Galectin-3 in Human Colon Cancer Cells Shumei Song*, Yuko Mori-Akiyama, Kaifeng Liu, Benoit de Crombrugghe, Robert S. Bresalier

8:45 #534

Wnt/β-Catenin Activation in TGF-β Pathway ELF +/-, and ELF +/-/SMAD3 +/- Mutant Mouse Models of Human Beckwith- Wiedemann Syndrome Rupen Amin*, Geeta Upadhyay, Wilma S. Jogunoori, Stephen R. Evans, Bibhutibushan Mishra, Premkumar Reddy, Lopa Mishra

P-84

10 San Diego Convention Center

ORAL SESSIONS—SCIENTIFIC SESSIONS ASGE Special Session 8:30 AM - 10:00 AM

5 San Diego Convention Center

ASGE Topic Forum 8:30 AM - 10:00 AM

2 San Diego Convention Center

Chairs: Thomas M. Deas, Colleen M. Schmitt

Chairs: Milton T. Smith, Jacques M.E. Deviere

THE GOVERNMENT AND THE ENDOSCOPIST

ERCP: NEW INNOVATIONS

8:30 Sp545

Washington and the Gastroenterologist - Now What? Richard F. Corlin

8:50 Sp546

State Level Action and Your GI Practice Scott M. Tenner

9:10 Sp547

The Act of Inaction - Constipation At the Political Level Colleen M. Schmitt

9:30

Questions & Answers

ASGE Topic Forum 8:30 AM - 10:00 AM

11 San Diego Convention Center

Chairs: Carol E. Semrad, Jonathan A. Leighton

8:30 #551

Timing of Precut Procedure Does Not Influence Success Rate and Complications of ERCP Procedure. A Prospective Randomized Comparative Study Vincenzo Cennamo*, Lorenzo Fuccio, Alessandro Repici, Carlo Fabbri, Diego Grilli, Massimo Conio, Nicola D'Imperio, Liboria Laterza, Liza Ceroni, Franco Bazzoli

8:42 #552

Endoscopic Removal of Uncovered, Partially & Fully Covered Biliary SEMS: Problems & Salvage Techniques. A GEPED Multicenter Descriptive Study Manuel Perez-Miranda*, Pedro González, Ferran GonzalezHuix, Carlos De la Serna, Francisco Perez-Roldan, Montserrat Figa

8:54 #553

Comparative Performance of Uncoated Self Expanding Metal Biliary Stents (SEMS) of Different Designs in Two Diameters: Final Patency Results of An International Multi-Center Randomized Controlled Trial (RCT) Douglas A. Howell*, Ramu Raju, Burr J. Loew, David J. Desilets, Paul P. Kortan, Gary R. May, Raj J. Shah, Yang K. Chen, Willis Parsons, Robert H. Hawes, Peter B. Cotton, Adam Slivka, Jawad Ahmad, Michael K. Sanders, Glen A. Lehman, Stuart Sherman, Horst Neuhaus, Brigitte Schumacher

9:06 #554

The Usefulness and Safety of Pancreatic Guidewire Placement for Achieving Deep Cannulation of the Bile Duct Kei Ito*, Naotaka Fujita, Yutaka Noda, Go Kobayashi, Jun Horaguchi, Osamu Takasawa, Takashi Obana

CONTEMPORARY SMALL BOWEL IMAGING 8:30 #545

Capsule Endoscopy (CE) Re-Assessment in a High Volume Center (HVC) Identifies Significant Misinterpretations of the Community Gastroenterologists (CG) That May Impact Clinical Care Patricio Ibanez*, Peter Simpson, Gil Y. Melmed, Shahab Mehdizadeh, Mamatha Sadda, Simon K. Lo

8:42 #546

Correlation of CT Enterography (CTE) and Capsule Endoscopy (CE) Findings in Patients Being Evaluated for Suspected Small Bowel (SB) Disease Daniel S. Mishkin*, Jaroslaw N. Tkacz, Brian C. Lucey

8:54 #547

Do Clinical Characteristics Predict Small Bowel Angiodysplasias On Capsule Endoscopy? Anthony T. DeBenedet*, Sameer D. Saini, Mimi S. Takami, Laurel Fisher

9:18 #555

SES+EPLBD Method Makes the Treatment of Large Common Bile Duct Stones Easy and Long Term Result Was Acceptable 5-Th Report Atsushi Minami*, Shinichi Hirata, Shoichiro Hyakawa

9:06 #548

Location and Distribution of Arteriovenous Malformations in the Small Bowel Based On Capsule Endoscopy As An Aid to Determine Anterograde Vs Retrograde Approach for Balloon Enteroscopy Gerard Isenberg*, Allen Lam

9:30 #556

The ERCP Quality Network. A Pilot Project for Comparing ERCP Practices and Performance Peter B. Cotton*, Donald A. Garrow, Douglas O. Faigel, Stephen E. Deal, Giuseppe Aliperti, Nancy J. Vacante

9:42 Sp549

State-of-the-Art Lecture: Improving Outcomes in Biliary Endoscopy Gregory B. Haber

9:18 #549

Post-Procedure Elevated Amylase and Lipase Levels After Double Balloon Enteroscopy: Relations with the Double Balloon Technique Cengiz Pata*, Umit Akyuz, Yusuf Erzin, Nilgun Mutlu, Arzu Mercan

9:30 #550

The Spiral Enteroscopy Experience in 101 Consecutive Patients: Safety and Efficacy Using the Discovery SB Paul A. Akerman*, Daniel Cantero, Jose Avila, Jesus Pangtay, Deepak Agrawal

9:42 Sp548

State-of-the-Art Lecture: Update in Small Bowel Imaging: Capsule Endoscopy, Balloon-Assisted Enteroscopy, and CT Enteroscopy Lauren B. Gerson

SSAT Conference/Debate/Panel/Symposium 9:30 AM - 11:00 AM 24ABC San Diego Convention Center Chair: Bruce D. Schirmer

T U E S D A Y MAY 20

Sponsored by: AHPBA

SSAT/AHPBA JOINT SYMPOSIUM: CURRENT APPROACH TO CARCINOMA OF THE GALLBLADDER 9:30 Sp550

Preoperative Detection and Approach to the Suspicious Gallbladder Reid B. Adams

9:45 Sp551

Intraoperative Approach to An Unexpectedly Detected Lesion During Lap Cholecystectomy Charles M. Vollmer

10:00 Sp552

Treatment Plan When Last Week's Routine Lap Cholecystectomy Returns Cancer Brett C. Sheppard

P-85

ORAL SESSIONS—SCIENTIFIC SESSIONS 10:15 Sp553

Current Best Options for Stage III Disease Yuman Fong

10:30

Panel and Audience Discussion

SSAT Plenary Session 10:00 AM - 11:15 AM

25 San Diego Convention Center

Chairs: David Shibata, Sharon M. Weber

10:06 #563

A New Biomechanical Device to Augment Lower Esophageal Sphincter (LES) Continence in Patients with Gastroesophageal Reflux Disease (GERD). Initial Results of a Pilot Clinical Trial Luigi Bonavina*, Greta Saino, Davide Bona, Tom R. DeMeester, John C. Lipham, Robert A. Ganz, Daniel H. Dunn

10:12 #564

Long-Term Outcome After 92 Duodenum-Preserving Pancreatic Head Resections for Chronic Pancreatitis: Comparison of FREY- and BEGER-Procedures Tobias Keck*, Ulrich Adam, Hartwig Riediger, Ulrich T. Hopt, Frank Makowiec

10:18 #565

Is Liver Resection Justified in Advanced Hepatocellular Carcinoma? Results of An Observational Study in 464 Patients Andrea Ruzzenente*, Franco Capra, Calogero Iacono, Gianluca Piccirillo, Marta Lunardi, Stefano Pistoso, Alessandro Valdegamberi, Alfredo Guglielmi

10:25 #566

An Improved Method of Assessing Esophageal Emptying Using the Timed Barium Study Following Surgical Myotomy for Achalasia Arzu Oezcelik*, Jeffrey A. Hagen, James M. Halls, Jessica M. Leers, Emmanuele Abate, Shahin Ayazi, John C. Lipham, Farzaneh Banki, Steven R. DeMeester, Tom R. DeMeester

SSAT BASIC SCIENCE PLENARY (PLENARY SESSION IV) Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 10:00 #557

Epigenetic Regulation of WNT Signaling Pathway Genes in Inflammatory Bowel Disease (IBD) Neoplasia Mashaal Dhir*, Elizabeth A. Montgomery, Kornel Schuebel, Susan L. Gearhart, Nita Ahuja

10:15 #558

Sodium-Coupled Transport of Butyrate By SLC5A8 Mediates Tumor Suppression in the Colon. Gail Cresci*, Muthusamy -. Thangaraju, Darren Browning, Vadivel Ganapathy

10:31 #567

Manometric Profile After Laparoscopic Nissen Fundoplication and Endoluminal Fundoplication: A Comparative Study in Animals Silvana Perretta*, Bernard Dallemagne, Jacques Marescaux

10:30 #559

Applying Proteomics Based Biomarker Tools for the Accurate Diagnosis of Pancreatic Cancer John D. Christein*, Kyoko Kojima, Senait G. Asmellash, Christopher A. Klug, James A. Mobley

10:37 #568

10:45 #560

A Neurokinin-1 Receptor Antagonist (NK1RA) That Reduces Intraabdominal Adhesions Augments the AntiAdhesive Effects of a Hyaluronic Acid/ Carboxymethylcellulose (HA/CMC) Adhesion Barrier in Rats Rizal Lim*, Jonathan M. Morrill, Karen L. Reed, Adam C. Gower, Bilaal McCloud, Susan E. Leeman, Arthur F. Stucchi, James M. Becker

Immunologic Ignorance and Tolerance Both Play a Role in Hepatic Tumorigenesis Diego Avella*, Luis J. Garcia, Serene Shereef, Hephzibah Tagaram, Yixing Jiang, Mehrdad Nikfarjam, Niraj J. Gusani, Eric Kimchi, Kevin Staveley-O'Carroll

10:43 #569

Downregulation of Adiponectin /Adipor2 Is Associated with Hepatic Inflammation and Steatosis in Obese Mice Yanhua Peng, Drew A. Rideout*, Steven S. Rakita, Mini Sajan, Robert Farese, Min You, Michel M. Murr

10:50 #570

Ischemic Colitis Following Endovascular Aortoiliac Aneurysm Repair: A 10-Year Retrospective Review Aaron Miller*, Michael S. Marotta, Irini A. Scordi-Bello, Yolanda Tammaro, Celia M. Divino

10:56 #571

Perianal Fistula Occurring After Ileal Pouch for NonCrohn's Colitis: A Word of Caution Isabella Mor*, Bo Shen, Susan Shedda, Margaret O'Malley, Jeffery Hammel, Feza H. Remzi

11:02 #572

Resection Versus Laparoscopic Radiofrequency Thermal Ablation of Solitary Colorectal Liver Metastasis Eren Berber*, Michael Tsinberg, Conrad H. Simpfendorfer, Allan Siperstein

11:08 #573

Frequency of Extrapancreatic Neoplasms in Intraductal Papillary Mucinous Neoplasm of the Pancreas Compared to Pancreatic Adenocarcinoma and Referral Patients Kellie L. Mathis*, Kaye M. Reid Lombardo, Christina M. Wood, William S. Harmsen, Michael G. Sarr

11:00 #561

T U E S D A Y MAY 20

Differential Ileal Adaptation After Massive ProximalBased Small Bowel Resection: Importance of the GLUT2 Hexose Transporter Michael G. Sarr, Corey W. Iqbal*, Javairiah Fatima, Molly E. Gross

SSAT Quick Shots 10:00 AM - 11:15 AM

27B San Diego Convention Center

Chairs: Jonathan F. Critchlow, Julie A. Stein SSAT QUICK SHOTS I Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 10:00 #562

P-86

Perioperative Allogenic Blood Transfusions Significantly Affect Survival Following Transthoracic En Bloc Resection for Esophageal Cancer Daniel Vallbohmer*, Frederike C. Ling, Daniel Schmidt, Roland Grunenberg, Birgit S. Gathof, Elfriede Bollschweiler, Arnulf H. Hoelscher, Paul M. Schneider

ORAL SESSIONS—SCIENTIFIC SESSIONS AASLD State-of-the-Art-Lecture 10:30 AM - 11:30 AM

7B San Diego Convention Center

AGA Institute Overarching Basic Science Symposium 10:30 AM - 12:00 PM 6F San Diego Convention Center

Chair: Douglas R. LaBrecque

Chairs: Deborah C. Rubin, Marshall H. Montrose

WILSON DISEASE

Sponsored by: AGA Institute

Participants will be able to: • Understand the pathophysiology of Wilson disease; • Understand how to diagnose Wilson disease; and • Understand how to best treat Wilson disease.

ANEUPLOIDY, APOPTOSIS AND CANCER

10:30 Sp554

Wilson Disease Michael L. Schilsky

AGA Institute Address/Oration/Lecture 10:30 AM - 11:30 AM 6B San Diego Convention Center

Participants will be able to: • State how aneuploidy might impact cancer; and • List the effects of apoptosis, cancer and inflammatory disorders. 10:30 Sp560

Apoptosis, Cancer and Inflammatory Disorders John C. Reed

11:15 Sp561

Aneuploidy and Cancer Don W. Cleveland

Sponsored by: AGA Institute; Research Policy Committee

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM 29 San Diego Convention Center

ROME FOUNDATION AGA INSTITUTE LECTURESHIP

Chairs: Paul P. Kortan, Nuzhat A. Ahmad

Participants will be able to: • Help physicians understand the needs of patients; • Provide recommendations to improve the patient-physician relationship and patient management; and • Identify simple measures to make clinical practice more satisfying to both the practitioner and patient.

Sponsored by: Imaging & Advanced Technology; Clinical Practice; Gastrointestinal Oncology; Esophageal, Gastric & Duodenal Disorders

Chairs: Douglas A. Drossman, Lin Chang

10:30 Sp555

Lessons from Our Patients Gina Kolata

DDW Combined Clinical Symposium 10:30 AM - 12:00 PM 20BCD San Diego Convention Center

ADVANCES IN IMAGING FOR THE EVALUATION AND MANAGEMENT OF SMALL BOWEL DISORDERS Participants will be able to: • Become familiar with advances in direct and indirect small bowel imaging; • Compare advantages and limitations of small bowel imaging options; and • Become aware of the therapeutic potential of small bowel imaging modalities.

Chairs: Martin L. Freeman, Kevin E. Behrns

10:30 Sp562

CT/MR Enterography Dean D. Maglinte

Sponsored by: AGA Institute; SSAT; ASGE

10:53 Sp563

Capsule Enteroscopy Ann M. Joyce

11:16 Sp564

Overtube Mediated Enteroscopy Paul A. Akerman

11:38 Sp565

Balloon-Based Enteroscopy Simon K. Lo

MANAGING COMPLICATIONS OF GI PROCEDURES Participants will be able to: • Recognize the clinical presentation of complications of gastrointestinal procedures; • Thoroughly evaluate and assess complications of gastrointestinal procedures; and • Appropriately manage by medical, interventional or surgical methods complications of gastrointestinal procedures. 10:30 Sp556

Complications of Esophagogastroduodenoscopy (EGD) and Endoscopic Muscosal Resection (EMR) Jonathan Cohen

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM 6A San Diego Convention Center Chairs: Henry P. Parkman, Braden Kuo

10:53 Sp557

Complications of Colonoscopy Douglas B. Nelson

Sponsored by: Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Neurogastroenterology and Motility

11:16 Sp558

Complications of Endoscopic Retrograde Cholangiopancreatiography Martin L. Freeman

CLINICAL CONTROVERSIES IN FUNCTIONAL DYSPEPSIA

11:38 Sp559

Role of Surgery in Management of Endoscopic Complications George A. Sarosi

Participants will be able to: • Review the competing theories underlying the pathophysiology of functional dyspepsia; • Review the data supporting key treatments for functional dyspepsia; and • Bring evidence to bear on developing a rational and cost-effective approach to treating functional dyspepsia. 10:30 Sp566

Is FD Caused By H. pylori or Acid? The Case for “Test and Treat” and PPIs Paul Moayyedi

P-87

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS 10:53 Sp567

Is FD a Motility Problem? the Case for Prokinetics Brian E. Lacy

11:16 Sp568

Is FD Caused By Visceral Hypersensitivity? The Case for TCAs and Other Pain Modulators Uri Ladabaum

11:38 Sp569

Putting It Together: What's the Best Approach to Treating FD? Brennan M. Spiegel

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM 20A San Diego Convention Center Chairs: Simon Travis, Jeffrey S. Hyams Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease; Growth, Development & Aging ; Clinical Practice

CLINICAL ISSUES IN IBD Participants will be able to: • Become familiar with the recent therapeutic advances in pediatric inflammatory bowel disease including biologic therapy; • Learn about the options for optimizing biologic therapy in inflammatory bowel disease including monotherapy, use of a loading dose, and systematic maintenance therapy; and • Describe the extra-intestinal manifestations of inflammatory bowel disease and the side effects of IBD treatments on the other organ systems. 10:30 Sp570

Advances in the Therapy of Pediatric IBD Athos Bousvaros

11:00 Sp571

Extra-Intestinal Manifestations of IBD: Is It the Disease or Is It the Drugs? Daniel C. Baumgart

11:30 Sp572

Optimizing the Administration of Biologics for IBD Remo Panaccione

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM 2 San Diego Convention Center

T U E S D A Y MAY 20

Chairs: Michael F. Vaezi, Colin W. Howden Sponsored by: Esophageal, Gastric & Duodenal Disorders; Clinical Practice; Neurogastroenterology and Motility

EXTRA-ESOPHAGEAL GERD: CAUSES, OUTCOMES, TREATMENT Participants will be able to: • Recognize the spectrum of extra-esophageal GERD; • Identify mechanisms of extra-esophageal GERD; and • Learn management of extra-esophageal GERD. 10:30 Sp573

Asthma: So What If They Have Heartburn? Susan Harding

10:53 Sp574

Chest Pain: Are They All Functional? Ravinder K. Mittal

11:16 Sp575

Sleep: Should Gastroenterologists Be Interested? Ronnie Fass

11:38 Sp576

LPR and Cough: Real GI Disease or Made-Up ENT Findings? Michael F. Vaezi

P-88

AGA Institute Committee Sponsored Symposium 10:30 AM - 12:00 PM 26A San Diego Convention Center Sponsored by: Practice Management & Economics Committee; Public Affairs and Advocacy Committee; Clinical Practice & Quality Management Committee

AGA 2008 LEGISLATIVE REPORT FROM WASHINGTON Participants will be able to: • Gain a better understanding of the issues affecting the practice of gastroenterology; • Identify what AGA/AGA institute is doing to address these issues and how members can help; and • Explore how to prepare yourself and your practice for the future. 10:30 Sp577

Practice Management and Economics: Key Programs and Developments Joel V. Brill

10:48 Sp578

Clinical Practice and Quality Measures: AGA Initiatives and Their Impact On GI Practice John I. Allen

11:06 Sp579

Public Affairs and Advocacy: Update On Federal Public Policy Activities Ronald P. Fogel

11:24 Sp580

AGA PAC and Your Role in Advancing the AGA Legislative Agenda Ralph A. Giannella

11:42 Sp581

Practice Management Resources for GIs Cecile M. Katzoff

AGA Institute Translational Symposium 10:30 AM - 12:00 PM 28ABC San Diego Convention Center Chairs: Dana Philpott, Sandra C. Kim Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease; Intestinal Disorders

ADHERENT/INVASIVE E. COLI IN CROHN'S DISEASE Participants will be able to: • Identify the association of AIEC with Crohn's disease; • Identify the mechanisms of AIEC attachment and invasion; and • Become aware of how the virulence factors associated with AIEC can cause disease. 10:30 Sp582

Mechanisms of Attachment Invasion and Persistence Arlette Darfeuille-Michaud

11:00 Sp583

Phenotype and Virulence Factors of E. coli Isolated from Crohn's Disease and Boxer Dogs Kenneth W. Simpson

11:30 Sp584

Functional Characteristics of E. coli Strains with Variable Abilities to Induce Experimental Colitis R. Balfour Sartor

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Translational Symposium 10:30 AM - 12:00 PM 32AB San Diego Convention Center

11:00 #577

HCV-Induced Oxidative Stress Suppresses Basal and Il6Stimulated Hepcidin Expression in Human Hepatoma Cell Lines Kouichi Miura*, Kojiro Taura, Yuzo Kodama, David A. Brenner

11:30 #578

Human Serum Amyloid P (Hsap) Inhibits Bile Duct Ligation Induced Liver Fibrosis in Mice Tatiana Kisseleva*, George Notas, Kojiro Taura, Yuzo Kodama, Samuele De Minicis, Mike Kramer, David P. Hesson, Tim Pelura, David A. Brenner

Chairs: Nathalie Vergnolle, John B. Furness Sponsored by: Neurogastroenterology and Motility; Esophageal, Gastric & Duodenal Disorders; Hormones, Transmitters, Growth Factors, & Their Receptors

INFLAMMATION-INDUCED CHANGES IN ENTERIC NEURON FUNCTION AND THEIR SIGNIFICANCE Participants will be able to: • Discuss cellular basis of changes in the ENS; and • Identify aspects of the cascade of events between inflammation and the changes in enteric neuron and effector cell function. 10:30 Sp585

Enteric Neuronal Responses to Inflammation - Effects At a Distance, in Space and Time Keith A. Sharkey

10:52 Sp586

Neuron Sub-Type Specific Effects of Inflammation and Their Implications Kulmira Nurgali

11:14 Sp587

Signalling Molecules and Enteric Neuron Plasticity Following Inflammation Fievos L. Christofi

11:36 Sp588

Clinical Manifestations of Enteric Neuropathies of Inflammation Roberto De Giorgio

ASGE Clinical Symposium 10:30 AM - 12:00 PM

AGA Institute Topic Forum 10:30 AM - 12:00 PM

Chairs: Yvonne Romero, Bruce D. Greenwald Sponsored by: Esophageal, Gastric & Duodenal Disorders; Intestinal Disorders

BARRETT'S ESOPHAGUS: DIAGNOSIS AND MANAGEMENT Participants will be able to: • Learn updates in Barrett's Esophagus diagnosis and management. 10:30 #579

Microscopic Barrett's Esophagus (MBE) - An Entity of Concern in the Progerd Study Andreas Leodolter*, Marc Nocon, Michael Vieth, Tore Lind, Daniel Jaspersen, Michael R. Höcker, Stefan Willich, Manfred Stolte, Peter Malfertheiner, Joachim Labenz

10:45 #580

Cell Senescence As a Potential Mechanism of p16 Mediated Resistance to Ablation of Barrett's Esophagus (Be) In Vivo Kenneth K. Wang*, Rami J. Badreddine, Ganapathy A. Prasad, Navtej Buttar, Wytske Westra, Cathrine J. DeMars, Marlys Anderson, Lori S. Lutzke, Kelly T. Dunagan, Lynn S. Borkenhagen

11:00 #581

Predictors of Adequate Biopsy Sampling in Patients with Barrett's Esophagus: Analysis of a National CommunityBased Gastrointestinal Pathology Database Julian A. Abrams*, Charles J. Lightdale, Anuradha V. Singhal, Thida Lwin, Robert C. Kapel

11:15 #582

Cyclooxygenase-2 Expression in Esophageal Epithelium Before and After Photodynamic Therapy for Barrett's Esophagus Patrick S. Yachimski*, Mari Mino-Kenudson, Margaret E. Sherwood, William P. Puricelli, Norman S. Nishioka, Gregory Y. Lauwers

11:30 #583

MYo9B Polymorphisms and Expression As Predictors for the Risk of Barrett's Esophagus and Esophageal Adenocarcinoma in Reflux Patients Vivianda Menke*, Katinka P. van Zoest, Leon M. Moons, Raymond G. Pot, Herman van Dekken, Bettina E. Hansen, Peter D. Siersema, Ernst J. Kuipers, Johannes G. Kusters

6C San Diego Convention Center

Chairs: Gary W. Falk, David A. Katzka EOSINOPHILIC ESOPHAGITIS 10:30 Sp589

Introduction David A. Katzka

10:35 Sp590

New Insights Into Epidemiology and Pathophysiology of Eosinophilic Esophagitis Glenn T. Furuta

10:55 Sp591

Pitfalls and Pearls in the Diagnosis of Eosinophilic Esophagitis Chris A. Liacouras

11:15 Sp592

Optimal Management of Eosinophilic Esophagitis: 2008 Ikuo Hirano

11:35 Sp593

Summary Gary W. Falk

11:40

Questions & Answers

AASLD Young Investigator Plenary 10:30 AM - 12:00 PM 7A San Diego Convention Center

9 San Diego Convention Center

11:45 Sp594

Summary Lecture: Diagnostic and Management Issues in Barrett's Esophagus: An Update Bruce D. Greenwald

Chairs: Scott L. Friedman, Joel E. Lavine YOUNG INVESTIGATOR PLENARY II 10:30 #574

Down-Regulation of SULF1 By Hypermethylation Mediates Resistance of Hepatocellular Carcinoma Cells to Chemotherapy-Induced Apoptosis Abdirashid M. Shire*, Jinping Lai, Hongzhi Zou, Ileana Aderca, Catherine D. Moser, Robert B. Jenkins, Lewis R. Roberts

P-89

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 10:30 AM - 12:00 PM

10 San Diego Convention Center

Chairs: Peter H. Green, Ciaran P. Kelly Sponsored by: Intestinal Disorders

11:00 #592

Enteral and Parenteral Nutrition Modulates Intestinal Permeability and Systemic Inflammation Claudia Guzy*, Daniela Paclik, Axel U. Dignass, Bertram Wiedenmann, Andreas Sturm

11:15 #593

Antibiotic Prophylaxis Significantly Reduces Infection Rates At Paediatric Percutaneous Endoscopic Gastrostomy (PEG) Tube Insertion: Results of An RCT Michelle L. Wilson, Catherine E. Paxton, David Hoole, Fraser D. Munro, Peter M. Gillett, David C. Wilson*

11:30 #594

Re-Hospitalization and Mortality of Home Parenteral Nutrition in the Long-Term Adult Patient Mohammad R. Taheri*, Cindy Hamilton, Rocio Lopez, Douglas L. Seidner, Ezra Steiger

11:45 #595

Early Jejunal Feeding Initiation and Optimization of Feeding Goals Improve Clinical Outcomes in Patients with Severe Acute Pancreatitis Amit Raina, Toby O. Graham, Susan Rolniak, Patty K. Centa-Wagner, Hossam m. Kandil, David C. Whitcomb, Stephen J. O'Keefe, Refaat Hegazi*

CLINICAL ADVANCES IN CELIAC DISEASE Participants will be able to: • Review the clinical advances in celiac disease. 10:30 #584

10:45 #585

11:00 #586

11:15 #587

11:30 #588

11:45 #589

T U E S D A Y MAY 20

Gluten Sensitivity of Endomysial Antibody-Positive Adults Without Villous Atrophy. Should the Current Diagnostic Criteria of Celiac Disease Be Revisited? a Prospective, Randomized and Controlled Clinical Trial Kalle Kurppa*, Pekka Collin, Mervi Viljamaa, Paivi Holopainen, Katri Haimila, Kaija Laurila, Kaija Paasikivi, Markku Mäki, Katri Kaukinen A Randomized, Double-Blind Study of AT-1001 for the Prevention of Celiac Disease Activation with Gluten Challenge Daniel A. Leffler*, Ciaran Kelly, Blake M. Paterson, Hani Abdullah, Anthony Colatrella, Joseph a. Murray Proteases from Germinating Wheat Decrease the Toxic Effects of Celiac Disease-Inducing Wheat Gliadin Satumarja Stenman*, Katri Lindfors, Jarkko Venalainen, Pekka T. Mannisto, Katri Kaukinen, Markku Mäki Role of the Innate Immune System in the Pathogenesis of Gluten Sensitivity : Preliminary Study Anna Sapone*, Lucia Imbrici, Maria Teresa Giuliano, Marcella Cammarota, Mario De Rosa, Maria Cartenì, Carlo Tolone, Alfonso Papparella, Valeria Familiari, Karen Lammers, Laura de Magistris, Alessio Fasano, Gabriele Riegler The Silence of the Intestines: Increased Prevalence and Mortality of Undiagnosed Celiac Disease Alberto Rubio-Tapia*, Brian Lahr, Alan R. Zinsmeister, Kyle A. Robert, L. Joseph Melton, Tricia L. Brantner, Carol T. Van Dyke, Tara K. Phelps, Edward L. Kaplan, Joseph a. Murray Relationship Between Galectin-10 Expression and Severity of Celiac Disease Abolished in the Presence of Gamma/Delta+T Cell Clonal Expansion Renato Cannizzaro*, Valli De Re, Laura Caggiari, Maria Paola Simula, Michele Spina, Vincenzo Canzonieri

AGA Institute Research Forum 10:30 AM - 12:00 PM

4 San Diego Convention Center

Chairs: Thomas R. Ziegler, John K. DiBaise

AGA Institute Research Forum 10:30 AM - 12:00 PM

Chairs: Stephen J. Keely, Seema Khurana Sponsored by: Intestinal Disorders

ENTEROCYTE BIOLOGY Participants will be able to: • Become familiar with recent research in enterocyte biology. 10:30 #596

Downregulation of Importin α and Inhibition of Nuclear Translocation of VEGFR2 and Hif1α in Capillary Endothelial Cells: Novel Mechanisms of Aging-Related Impairment of Angiogenesis in Gastric Mucosa. Amrita Ahluwalia*, Michael K. Jones, Xiaoming Deng, Andrzej Tarnawski

10:45 #597

Endothelin-3 Stimulates Survival of Goblet Cells in Organotypic Cultures of Human Colonic Epithelium Jiri Kalabis*, Gang Li, Mizuho Fukunaga-Kalabis, Anil K. Rustgi, Meenhard Herlyn

11:00 #598

Efficient Gene Delivery and Sustained Gene Expression in the Intestinal Epithelium of the Small Bowel and Colon Steven F. Polyak*, Andres Acosta, Stacy L. Porvasnik, Thomas Conlon, Annette Mach, John F. Valentine, Martha Campbell-Thompson, Cathryn Mah

11:15 #599

Abnormal Expression of Apical Recycling Endosome Proteins in Microvillous Inclusion Disease Magdalena Golachowska*, Juul F. Baller, Rytis Prekeris, Dick Hoekstra, Edmond H. Rings, Sven C. IJzendoorn

11:30 #600

Constitutive Nitric Oxide (CNO) Inhibits Na-Glucose Co-Transport By Altering the Glycosylation of the SGLT1 Co-Transporter in the Intestinal Epithelial Cells Subha Arthur*, Prosenjit Saha, Ramesh Kekuda, Steven Coon, Uma Sundaram

11:45 #601

The Consequences of Mucin MUC2 Deficiency On Intestinal Inflammation During Post-Natal Development and Suckling-Weaning Transition in Mice Maria van der Sluis*, Nanda Burger-van Paassen, Anita M. Korteland-Van Male, Isabelle VAN SEUNINGEN, Johannes B. van Goudoever, Ingrid B. Renes

Sponsored by: Nutrition & Obesity

ENTERAL AND PARENTERAL NUTRITION Participants will be able to: • Learn more about basic and clinical aspects of enteral and parenteral nutrition. 10:30 #590

What Is the Most Appropriate Gastric Residual Volume to Identify Delayed Gastric Emptying in Critically Ill Patients? Nam Q. Nguyen*, Katrina Ching, Robert J. Fraser, Ross N. Butler, Richard H. Holloway

10:45 #591

Whole Blood Free Choline and Choline Metabolites in Infants On Chronic Parenteral Nutrition Therapy Timothy Sentongo*, Praveen Kumar, Betsy Hjelmgren, Lisa Keys, Kishore Iyer, Alan L. Buchman

P-90

30C San Diego Convention Center

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 10:30 AM - 12:00 PM

30A San Diego Convention Center

Chairs: Noah F. Shroyer, Lopa Mishra Sponsored by: Growth, Development & Aging; Intestinal Disorders

MEDIATORS OF CELL FATE IN THE GI TRACT Participants will be able to: • Understand transcription factors determining cell fate in the GI tract; • Learn about signaling pathways that influence GI tract development; and • Describe factors that mediate patterning in the GI tract. 10:30 #602

10:45 #603

11:00 #604

The Absence of GATA4 in the Distal Small Intestine Defines the Ileal Phenotype Eva Beuling*, Ilona M. Kerkhof, Christina M. Piaseckyj, Paul A. Dawson, William T. Pu, Richard J. Grand, Stephen D. Krasinski Notch Signaling in Pancreatic Islet Precursor Cells Inhibits Endocrine Differentiation and Favors a Duct Cell Fate Archana Kapoor*, Maryann Giel-Moloney, Guido Rindi, Andrew B. Leiter Notch Signaling Suppresses the Transcriptional Activity of Hath1 Gene, Resulting in the Undifferentiated Form of Human Intestinal Epithelial Cells Kiichiro Tsuchiya*, Kazunari Inoue, Mikayo Arakaki, Ryuichi Okamoto, Tetsuya Nakamura, Takanori Kanai, Mamoru Watanabe

11:15 #605

Signaling Through Fibroblast Growth Factor Receptor 3 Modulates Tcf4/β-Catenin Activation and Paneth Cell Lineage Allocation in Intestinal Crypt Epithelial Cells Alda Vidrich*, Brooks Brodrick, Jenny M. Buzan, Steven M. Cohn

11:30 #606

KLF4 Is a Downstream Target of the Notch Signaling Pathway That Controls Goblet Cell Differentiation in the Mouse GI Tract Xiangdong Yang, David M. Pritchard, Shigeo Takaishi, Shuiping Tu, Frédéric Marrache, Shanisha A. Gordon, Timothy C. Wang, Walden Ai*

11:45 #607

PDX1 Inactivation Restricted to the Intestinal Epithelium in Mice Alters Duodenal Gene Expression in Enterocytes, Paneth and Enteroendocrine Cells Chin Chen*, Rixun Fang, Corrine Davis, Eric Sibley

AGA Institute Research Forum 10:30 AM - 12:00 PM

8 San Diego Convention Center

10:45 #609

Hp0244 (FLGs) Is An Essential Cytoplasmic pH Sensor for Helicobacter pylori Acid Adaptation Yi Wen*, Jing Feng, David R. Scott, Elizabeth A. Marcus, George Sachs

11:00 #610

dupA Polymorphisms and Risk of Distal Gastric Carcinoma Dulciene M. Queiroz*, Gifone A. Rocha, Luciana I. Gomes, Taciana F. Soares, Fabricio F. Melo, Andreia Maria C. Rocha, Sílvia B. Moura, Celso A. Oliveira

11:15 #611

ROS-Dependent Modification of Intra-Gastric Epithelial Cell Proteins By Helicobacter pylori cagA Osamu Handa*, Yuji Naito, Hitomi Okada, Natsuko Hayashi, Ikuhiro Hirata, Tatsushi Omatsu, Satoko Adachi, Tetsuya Okayama, Satomi Akagiri, Takahiro Suzuki, Katsura Mizushima, Tomohisa Takagi, Satoshi Kokura, Hiroshi Ichikawa, Hirofumi Matsui, Takeshi Azuma, Toshikazu Yoshikawa

11:30 #612

Infection By Helicobacter pylori Expressing the BaBa Adhesin Is Influenced By the Secretor Phenotype Maria Azevedo, Sara Eriksson, Nuno M. Mendes, Jacinta Serpa, Ceu Figueiredo, Nathalie Ruvoën-Clouet, Rainer Haas, Thomas Borén, Jacques Le Pendu, Leonor David*

11:45 Sp595

State-of-the-Art Overview Steven F. Moss

AGA Institute Research Forum 10:30 AM - 12:00 PM

Chairs: Oliver G. Opitz, Courtney W. Houchen Sponsored by: Gastrointestinal Oncology

REGULATION OF PROLIFERATION, APOPTOSIS AND CELL CYCLE IN GASTROINTESTINAL CANCERS Participants will be able to: • Become familiar with regulation of proliferation, apoptosis and cell cycle in GI cancers. 10:30 #613

Loss of Phlpp Expression in Colon Cancer: Role in Proliferation and Tumorigenesis Jianyu Liu*, B. M. Evers, Tianyan Gao

10:45 #614

RNA Binding Protein RBM3: A Novel Protooncogene Required for Tumor Cells to Overcome G2/M Arrest and Mitotic Catastrophe Gopalan Natarajan*, Satish Ramalingam, Sripathi M. Sureban, Randal May, Courtney W. Houchen, Shrikant Anant

11:00 #615

Knockdown of Musashi-1 Results in p21Waf-1 Induction During G2/M Arrest and Mitotic Catastrophe Via Inhibition of Notch Signaling Sripathi M. Sureban*, Randal May, Robert George, Brian K. Dieckgraefe, Shrikant Anant, Courtney W. Houchen

Chairs: Nicola L. Jones, Yoshio Yamaoka Sponsored by: Esophageal, Gastric & Duodenal Disorders

11:15 #616

Mouse Embryonic Fibroblasts Null for the Krüppel-Like Factor 4 Alleles Are Genetically Unstable Engda G. Hagos*, Amr Ghaleb, W Brian Dalton, Jonathan P. Katz, Klaus H. Kaestner, Vincent W. Yang

11:30 #617

The Mtor Complex 2 Regulates the Proliferation of Colon Cancer Cells Qingsong Cai*, Jing Li, Tianyan Gao, B. M. Evers

11:45 #618

Genetic Ablation of M3 Muscarinic Receptors Attenuates Both Colon Epithelial Cell Proliferation and Neoplasia Jean-Pierre Raufman*, Roxana Samimi, Nirish Shah, Sandeep Khurana, Guofeng Xie, Cinthia Drachenberg, Kunrong Cheng

MICROBIAL MEDIATORS OF H. PYLORI PATHOGENESIS Participants will be able to: • Understand the bacterial factors that contribute to H. pylori-induced diseases. 10:30 #608

The Effect of Natural Polymorphisms Upstream of the Helicobacter pylori Vacuolating Cytotoxin Gene, vacA, On vacA Transcription Levels Charlotte G. Masters*, Darren Letley, John C. Atherton

30E San Diego Convention Center

P-91

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 10:30 AM - 12:00 PM

28DE San Diego Convention Center

30B San Diego Convention Center

Chairs: Linda Rabeneck, David Weinberg

Chairs: Laurel Fisher, Karen E. Hall

Sponsored by: Gastrointestinal Oncology

Sponsored by: Growth, Development & Aging; Gastrointestinal Oncology

SCREENING AND DIAGNOSIS OF GASTROINTESTINAL CANCERS I Participants will be able to: • Learn more about screening and diagnosis in GI cancers. 10:30 #619

10:45 #620

11:00 #621

11:15 #622

11:30 #623

T U E S D A Y

AGA Institute Topic Forum 10:30 AM - 12:00 PM

11:45 #624

MAY 20

P-92

Randomized Study Comparing the Test Performance of a Guaiac-Based Fecal Occult Blood Test with An Immunochemical Fecal Occult Blood Test for Colorectal Cancer Screening in a Screening Population Leo van Rossum*, Anne Floortje van Rijn, Robert Laheij, Andre L. Verbeek, Martijn G. van Oijen, Paul Fockens, Jan B. Jansen, Evelien Dekker The Value of Interval Fecal Occult Blood Testing in Colonoscopy-Based Surveillance Program (CSP) for People At Increased Risk for Colorectal Cancer Elizabeth C. Chow, Joanne M. Lane, Alicia Smith, Stephen Cole, Joylene M. Morcom, Peter A. Bampton, Graeme P. Young* Attendance to Screening for Colorectal Cancer in the Netherlands; Randomized Controlled Trial Comparing Two Different Forms of Faecal Occult Blood Tests and Sigmoidoscopy Lieke Hol*, M. E. Leerdam van, Marjolein van Ballegooijen, Anneke van Vuuren, Jaqueline C. Reijerink-Verheij, Alexandra C. van der Togt-van Leeuwen, J. D. Habbema, E. J. Kuipers Adjusting Cut-Off Values of Immunological FOBT Allows Tuning of CRC Screening Programs to Colonoscopy Capacity Frank A. Oort*, Jochim S. Terhaar sive Droste, Mike E. Craanen, René W. van der Hulst, Henk van Heukelem, Ruud J. Loffeld, Eric C. Wesdorp, Gerrit A. Meijer, Chris J. Mulder Colonoscopic Screening At 5-Year After Initial Examination in Average Risk Subjects: A Prospective Study Wai K. Leung*, James Y. Lau, Bing-yee Suen, Grace Wong, Dorothy K. Chow, Larry Lai, Ka-Man C. Yim, Sau Fong E. Lee, Joseph J. Sung Factors Associated with Risk of Serious Complications of Colonoscopy: A Population-Based Study Linda Rabeneck*, Lawrence Paszat, Robert J. Hilsden, Refik Saskin, Des Leddin, Eva Grunfeld, Elaine S. Wai, Meredith A. Goldwasser, Therese A. Stukel

AGING: EFFECTS ON GI FUNCTION AND PHYSIOLOGY Participants will be able to: • Understand age related changes in the gastrointestinal mucosa; • Learn about changes in gut flora during aging; and • Define the role of colonoscopy screening in the elderly. 10:30 #625

Age-Related Changes in GI Mucosal Proliferation and Apoptosis: A Gene-Array Perspective Bhaumik B. Patel*, Yingjie Yu, Jianhua Du, Arun K. Rishi, Anil Wali, Adhip P. N. Majumdar

10:45 #626

Comparative Effects of Oral and Intraduodenal Glucose On Blood Pressure in Healthy Older Subjects Diana Gentilcore*, Nivasinee S. Nair, James H. Meyer, Michael Horowitz, Karen L. Jones

11:00 #627

Synbiotics Protect Against Oxidative Stress in Inflammatory Bowel Disease (IBD) By Inducing Phase 2 Response Enzymes Silvia C. Resta-Lenert*, Marco Maruggi, Coleman Ho

11:15 #628

Aging of the Colonic Bacterial Flora in Adults Paul Enck*, Julia Frick, Kurt Zimmermann, Sibylle Klosterhalfen

11:30 #629

Aging Attenuates PI3K/AKT Activation and Proliferation of Pancreatic Acinar Cells Hitoshi Takahashi*, Hiroshi Saito, B. M. Evers

11:45 #630

Screening Colonoscopy in the Elderly Improves Survival Emily Singh*, Catherine Frennette, Williamson Strum

AGA Institute Topic Forum 10:30 AM - 12:00 PM

30D San Diego Convention Center

Chairs: R. Alberto Travagli, Million Mulugeta Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors; Neurogastroenterology and Motility

HORMONES AND RECEPTORS IN THE GUT-BRAIN PATHWAY Participants will be able to: • Learn about receptors in the brain-gut axis and interactions between endocrine cells and visceral afferents; and • Identify the brain-gut circuits activated by peptides and involved in gluocse sensing. 10:30 #631

Peripheral Urocortin 2 Blocks the Gastric Motility Activation Induced By Ghrelin Guillaume Gourcerol*, Lixin Wang, Mulugeta Million, David W. Adelson, Tatsuro Tanaka, Yvette Tache

10:45 #632

Involvement of Cannabinoid CB1 Receptors and Calcitonin Gene Related Peptide (CGRP) in the Gastroprotective Action of Endocannabinoids Against Acute Gastric Lesions Slawomir Kwiecien*, Tomasz Brzozowski, Peter C. Konturek, Michal Pawlik, Danuta Drozdowicz, Zbigniew Sliwowski, Jakub Cieszkowski, Krystyna Zwirska-Korczala, Stanislaw J. Konturek, Wieslaw W. Pawlik

ORAL SESSIONS—SCIENTIFIC SESSIONS 11:00 #633

Agonists of Bitter Taste Receptors Activate Cellular Signaling in Endocrine Cells and Extrinsic Afferent Neurons in the Rat Shuzhen Hao*, James W. Sharp, Monica C. Chen, Enrique Rozengurt, Catia Sternini, Helen E. Raybould

11:15 #634

Ligand-Induced µ Opioid Receptor Internalization in Enteric Neurons Following Chronic Opiate Treatment Laura Anselmi*, Ingrid Jaramillo, Catia Sternini

11:30 #635

Activity-Dependent Modulation of Gastric Vagal Brainstem Circuits By Pancreatic Polypeptides Kirsteen N. Browning*, R. Alberto Travagli

11:45 #636

Different Brain Circuits Are Involved for Duodenal and Portal Glucose Sensing Jihane Boubaker, Sylvie Guérin, Alain Chauvin, Benoit Janson, Charles-Henri Malbert*

AGA Institute Topic Forum 10:30 AM - 12:00 PM

AGA Institute Topic Forum 10:30 AM - 12:00 PM

Chairs: Dhiraj Yadav, Jimmy Chow Sponsored by: Pancreatic Disorders; Gastrointestinal Oncology

PANCREATIC CANCER: HIGH RISK GROUPS AND TRANSLATIONAL STUDIES Participants will be able to: • Recognize the potential and limitations of current approaches to identifying high risk groups for pancreatic cancer; and • Discuss the application of novel technology to the problem. 10:30 #643

Temporal Association of Changes in Fasting Blood Glucose and Body Mass Index to Diagnosis of Pancreatic Cancer Rahul Pannala*, Cynthia L. Leibson, Kari G. Rabe, Lawrence J. Timmons, Jeanine E. Ransom, Mariza de Andrade, Gloria M. Petersen, Suresh T. Chari

10:45 #644

Surveillance and Natural History of High Risk Patients Who Inherit Pancreatic Cancer Michael D. Saunders*, David R. Byrd, Mary P. Bronner, Josephine Maurer, Irl Hirsch, Joo Ha Hwang, Michael B. Kimmey, Teresa Brentnall

11:00 #645

Pilot Study Examining Changes Induced in Duodenal Epithelial Cells By Different Pancreatic Diseases As Measured By a Novel Optical Imaging Modality, SingleCell Partial Wave Spectroscopy Microscopy Randall Brand*, Hariharan Subramanian, Hemant K. Roy, Nahla Hasabou, Vadim Backman

11:15 #646

Early Diagnosis of Precancerous Stage of Ductal Adenocarcinoma of the Pancreas Using a Novel Monoclonal Antibody Daphne C. Ang, Angela Sefah*, Kelly A. Walton, Malca Kierson, Michael S. Nagar, Kiron M. Das, Michael May

11:30 #647

High-Grade Pancreatic Intraepithelial Neoplasia (Panin) Is Associated with Local Recurrence of Pancreatic Adenocarcinoma After “Curative” Surgical Resection Caroline Hwang*, Heidrun Rotterdam, Aliye Z. Bill, Elizabeth Verna, Aimee L. Lucas, Nicole Goetz, John A. Chabot, Harold Frucht

11:45 #648

Adjuvant Chemotherapy Is More Beneficial in Elderly Patients with Resected Pancreatic Cancer Nam Q. Nguyen*, Amber l. Johns, Rupert W. Leong, Neil Merrett, Andrew V. Biankin

31BC San Diego Convention Center

Chairs: Lawrence J. Brandt, Lisa L. Strate Sponsored by: Clinical Practice; Intestinal Disorders; Immunology, Microbiology & Inflammatory Bowel Disease

NOVEL OBSERVATIONS IN LOWER GI DISORDERS Participants will be able to: • Review the latest data on risk factors for post-infectious IBS; • Discuss the potential role of calprotectin in identifying patients with infectious diarrhea; and • Understand risk factors and preventive strategies for diverticular complications. 10:30 #637

Clostridium difficile As a Causative Agent of PostInfection Irritable Bowel Syndrome (PI-IBS) Ari M. Grinspan, Oren E. Bernheim, Eleazer Yousefzadeh*, Rabin Rahmani, William Southern, Lawrence J. Brandt

10:45 #638

Chlamydia Trachomatis Antigen in Small Bowel Mucosa: A New Clue to Causality in Irritable Bowel Syndrome Aldona Dlugosz*, Hans Törnblom, Ghazaleh Mohammadian, Gareth Morgan, Benjamin Edvinsson, Gunnar Sandström, Greger Lindberg

11:00 #639

Comparative Evaluation of Fecal Calprotectin, Lactoferrin and Occult Blood Test in Predicting Microbiological Diagnosis for Acute Bacterial Diarrhea: Prospective Multicenter Study Yogesh Shastri*, Dominik Bergis, Nada Povse, Jürgen Stein

11:15 #640

The Incidence of and Mortality Associated with Perforated Colonic Diverticular Disease in the UK: A General Population Based Study David J. Humes*, Masoud Solaymani-Dodaran, Kate M. Fleming, John Simpson, Robin C. Spiller, Joe West

11:30 #641

Physical Activity Decreases the Risk of Diverticular Complications Lisa L. Strate*, Yan Liu, Edward L. Giovannucci

11:45 #642

Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety of Prucalopride (Resolor®) in Patients with Opioid-Induced Constipation Dwight E. Moulin, An Rykx, Rene Kerstens, Lieve Vandeplassche*

3 San Diego Convention Center

AGA Institute Topic Forum 10:30 AM - 12:00 PM

26B San Diego Convention Center

Chairs: James Galligan, Simon J. Gibbons Sponsored by: Neurogastroenterology and Motility; Hormones, Transmitters, Growth Factors, & Their Receptors

RECEPTORS AND SIGNALING Participants will be able to: • Understand signalling pathways activated by membrane receptors; and • Understand the role of membrane recptors in control of gastrointestinal function. 10:30 #653a

Glucose-Induced Modulation of Gastrointestinal Vagal Afferent Neurons and Their Central Nerve Terminals Kirsteen N. Browning

P-93

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS 10:45 #649

5-HT4 Stimulation Promotes the Generation of New Neurons and Enhances Neuronal Survival in the Enteric Nervous System (ENS) of Adult Mice Mintsai Liu*, Yung-Hui Kuan, Jingwen Wang, Rene Hen, Michael D. Gershon

11:00 #650

Localization and Function of Transient Receptor Potential (Trp) A1 Ion Channel in the Enteric Nervous System Daniel P. Poole*, Fiore Cattaruzza, Gregory R. Gai, Carlos U. Corvera, Nigel W. Bunnett, Eileen Grady

11:15 #651

Hyperpolarization of Nodose Ganglia in Chronic Hyperglycemia Rats Is Mediated By Activation of the Tandem-Pore K+ Channel Tresk Gintautas Grabauskas*, Il Song, Thomas Lanigan, Chung Owyang

11:30 #652

11:45 #653

Bmp2 Promotes Differentiation of a Novel Enteric Neuronal Cell Line Through the Smad Signaling Pathway Emad Qayed*, Mallappa Anitha, Gudrun Gossrau, Simon Mwangi, Shanthi V. Sitaraman, Shanthi Srinivasan Adenosine 2b (A2b)Receptor Knock Out Mice Have Impaired Colonic Motility Bindu P. Chandrasekharan*, Vasantha L. Kolachala, Guillaume Dalmasso, Didier Merlin, Shanthi V. Sitaraman, Shanthi Srinivasan

AGA Institute Topic Forum 10:30 AM - 12:00 PM

11:30 #658

CD44, Pancreatic Cancer Stem Cell Marker, Positive Cells Are Responsible for the Acquiring Gemcitabine Induced Chemoresistance In Vitro Sung Pil Hong*, Jeong Youp Park, Jing Wen, Jin Wook Yoon, Kyung Hwa Park, Seungmin Bang, Seung Woo Park, Si Young Song

11:45 #659

Identification and Characterization of Human ColonCancer Stem Cells M. Puglisi*, Nathalie Saulnier, A. Sgambato, M. Barba, Ernesto Cristiano Lauritano, A. Boninsegna, Anna C. Piscaglia, Marialuisa Novi, Maria Assunta Zocco, F. Barbaro, Francesca Fiore, S. Alfieri, G. Doglietto, A. Cittadini, F. Michetti, Antonio Gasbarrini

ASGE Topic Forum 10:30 AM - 12:00 PM

Chairs: Banke Agarwal, Mary L. Krinsky CURRENT TRENDS IN UPPER GASTROINTESTINAL NEOPLASIA 10:30 #660

Therapeutic Outcome in 1000 Cases of Endoscopic Submucosal Dissection (ESD) for Early Gastric Neoplasms; Korean ESD Study Group (KESG) MultiCenter Study Il Kwun Chung*, Hoi Jin Kim, Suck-Ho Lee, Tae Hoon Lee, Joo Young Cho, Bo Young Hwang, Bora Keum, JongJae Park, Hoon Jai Chun, Jun Haeng Lee, Jae J Kim, Sam Yong Ji, Sang Young Seol

10:42 #661

Which Endoscopic Resection Method Is Best to Treat Small Esophageal Cancers? Ryu Ishihara*, Hiroyasu Iishi, Noriya Uedo, Rika Miyoshi, Yoji Takeuchi

10:54 #662

A Cohort-Based Study of Missed and New Cancers After Gastroscopy Spiro C. Raftopoulos*, Dev S. Segarajasingam, Ian F. Yusoff, Hooi C. Ee

11:06 #663

Are “High Risk” Features Associated with Increased Gastrointestinal Pathology in Patients Aged Less Than 50 Years with Dyspepsia? Nick Powell*, Thomas A. Treibel, Joel Dunn, Joel Mawdsley, Rupert Negus, Timothy Orchard, Huw J. Thomas, Jonathan M. Hoare, Julian P. Teare

11:18 #664

Prognosis of Patients with Early Gastric Cancer Who Underwent Additional Gastrectomy After Incomplete Endoscopic Mucosal Resection Sung-Hoon Moon*, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Jin-Ho Kim

11:30 #665

The Changing Balance of Gastric Polyps: A Study of 5,972 Patients Mohammad H. Saboorian*, Christopher M. Schuler, Kevin Struckhoff, Robert M. Genta

11:42 Sp598

State-of-the-Art Lecture: Current Trends in Early Upper GI Cancer Christian Ell

33BC San Diego Convention Center

Chairs: Jean Marie Houghton, Shigeo Takaishi Sponsored by: Gastrointestinal Oncology; Growth, Development & Aging

STEM CELL BIOLOGY IN CANCERS Participants will be able to: • Evaluate recent research on stem cell biology in cancers. 10:30 #654

T U E S D A Y MAY 20

10:45 #655

11:00 #656

11:15 #657

P-94

K-RAS Mutation in Stem/Progenitor Cell Fraction of Gastric Epithelium Results in Early Onset of Gastric Dysplasia with Expansion of a Candidate Stem Cell Fraction Tomoyuki Okumura*, Shigeo Takaishi, Sheng-Wen Wang, Russell Ericksen, Wataru Shibata, Arlin B. Rogers, Barry H. Rickman, James G. Fox, Anil K. Rustgi, Timothy C. Wang Identification of a Specific Bone Marrow-Derived Cell (BMDC) Subset That Can Contribute to the Gastric Epithelium Tomoyuki Okumura*, Shigeo Takaishi, Sheng-Wen Wang, Shui Ping Tu, Vivian Ng, Russell Ericksen, Anil K. Rustgi, Timothy C. Wang Infusion of Bone Marrow Derived Cells (BMDC) in Nonradiated Mice with Chronic Helicobacter felis Infection Leads to Engraftment of Bmdc and Acceleration of Pre-Neoplastic Lesions Sheng-Wen Wang*, Tomoyuki Okumura, Russell Ericksen, Kelly S. Betz, Arlin B. Rogers, James G. Fox, Timothy C. Wang Distinguishing Quiescent Stem Cells from Cycling Progenitor Cells in Intestinal Crypts with the Recently Identified Novel Markers Dcamkl-1 and Lgr5 Randal May*, Sripathi M. Sureban, Shrikant Anant, Courtney W. Houchen

11 San Diego Convention Center

ORAL SESSIONS—SCIENTIFIC SESSIONS 11:06 #675

High Definition Endoscopy (HD+) with I-Scan and Lugol's Solution for the Detection of Inflammation and Neoplasia in Patients with GERD Arthur Hoffman*, Nina Basting, Martin Goetz, Stefan Biesterfeld, Peter R. Galle, Markus F. Neurath, Ralf Kiesslich

11:18 #676

Gene Analysis of Advanced Pancreatic Carcinoma Using EUS-Guided FNA with Focused DNA Array: Possible Predictor of the Chemotherapeutic Efficacy Reiko Ashida*, Bunzo Nakata, Minoru Shigekawa, Nobumasa Mizuno, Akira Sawaki, Kosei Hirakawa, Tetsuo Arakawa, Kenji Yamao

Digital Image Analysis (DIA) Is a Useful Adjunct to Endosonographic Diagnosis of Submucosal Lesions (SML) of the Gastro-Intestinal Tract Ananya Das*, Vien X. Nguyen, Cuong C. Nguyen

11:30 #677

10:42 #667

DNA Microsatellite Loss in Endoscopic UltrasoundGuided Fine Needle Aspirate from Pancreatic Endocrine Tumors Is Associated with Increased Mortality Kenneth E. Fasanella*, Kevin M. McGrath, Michael K. Sanders, Debra Brody, Robyn T. Domsic, Asif Khalid

In Vivo 3D Comprehensive Microscopy of the Human Esophagus for the Management of Barrett's Patients Melissa J. Suter*, Patrick S. Yachimski, Benjamin J. Vakoc, Milen Shishkov, Brett E. Bouma, Norman S. Nishioka, Guillermo J. Tearney

11:42 Sp600

State-of-the-Art Lecture: Enhanced Imaging: See the Future Prateek Sharma

10:54 #668

Measuring Mesothelin Protein Level in Endoscopic Ultrasound-Guided Fine Needle Aspiration Specimens A Novel Method in Pancreatic Adenocarcinoma Detection Dong Wang*, Zhendong Jin, Zhaoshen Li, Feng Li

11:06 #669

Standardized Weighted Criteria for EUS Features of Chronic Pancreatitis: The Rosemont Classification Lyndon V. Hernandez*, Anand Sahai, William R. Brugge, Maurits J. Wiersema, Marc F. Catalano

11:18 #670

Cytologic Evaluation of Cystic Pancreatic Lesions (CPL): Comparison of Echobrush vs. Standard EUS-FNA Techniques in a Blinded Prospective Study Kanwar R. Gill*, Mohammad A. Al-Haddad, Murli Krishna, Seth A. Gross, Laith H. Jamil, Timothy A. Woodward, Massimo Raimondo, Michael B. Wallace

ASGE Topic Forum 10:30 AM - 12:00 PM

5 San Diego Convention Center

Chairs: Asif Khalid, Michael B. Wallace ENDOSCOPIC ULTRASOUND - PANCREAS 10:30 #666

11:30 #671

11:42 Sp599

Neural Network Analysis of Dynamic Sequences of EUS Elastography Used for the Differential Diagnosis of Chronic Pancreatitis and Pancreatic Cancer Adrian Saftoiu*, Peter Vilmann, Florin Gorunescu, Dan Ionut Gheonea, Marina Gorunescu, Tudorel Ciurea, Gabriel Lucian Popescu, Alexandru Iordache, Sevastita Iordache

SSAT Address/Oration/Lecture 11:15 AM - 12:00 PM

SSAT MAJA AND FRANK G. MOODY STATE-OF-THE-ART LECTURE 11:15 Sp601

1 San Diego Convention Center

The Early Detection of Pancreatic Cancer: Lessons from Surveillance of 100 High-Risk Patients Teresa Brentnall

ASGE Interactive Education 12:00 PM - 2:00 PM

Marina Ballroom, Salon G Marriott Hotel & Marina

Chairs: Roy M. Soetikno, Gottumukkala S. Raju ENDOLUMINAL TISSUE APPROXIMATION AND PERFORATION CLOSURE (IE03) 12:00 Sp602

State-of-the-Art Lecture: Translational EUS Michael J. Levy

ASGE Topic Forum 10:30 AM - 12:00 PM

25 San Diego Convention Center

Endoluminal Tissue Approximation and Perforation Closure Shai Friedland, Takuji Gotoda, Tonya R. Kaltenbach, Tsuneo Oyama, Elizabeth Rajan, Richard I. Rothstein, Christopher C. Thompson

ASGE Poster Grand Rounds 12:15 PM - 1:00 PM

Chairs: Richard E. Sampliner, Amitabh Chak NEW IMAGING IN THE UPPER GI TRACT 10:30 #672

Confocal Laser Endomicroscopy for In Vivo Diagnosis of Barrett's Esophagus and Associated Neoplasia: An Ongoing Prospective Study Cristina Trovato*, Angelica Sonzogni, Giancarla Fiori, Davide Ravizza, Darina Tamayo, Giuseppe De Roberto, Paola Fontana, Giuseppe Viale, Cristiano Crosta

10:42 #673

Confocal Laser Endomicroscopy in Barrett's Esophagus and Associated Neoplasia: A Prospective Randomized Controlled Crossover Trial Kerry B. Dunbar*, Elizabeth A. Montgomery, Patrick Okolo, Marcia I. Canto

10:54 #674

In Vivo Imaging of Living Cancer Cell and Evaluation for Tissue Atypia Using Endocytoscopy: ECA (Endocytoscopic Atypia) Classification in the Esophagus and Stomach Haruhiro Inoue*, Hitomi Minami, Hitoshi Satodate, Makoto Kaga, Shigeharu Hamatani, Shin-ei Kudo

Sp603

Biliary & Pancreatic ERCP Martin L. Freeman

6C San Diego Convention Center

Sp604

EUS Michael B. Wallace

5 San Diego Convention Center

P-95

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS Sp616

DDW Meet-the-Investigator Luncheons 12:30 PM - 1:45 PM

26A San Diego Convention Center

Sp617

Participants will be able to: • Identify new scientific and clinical information relevant to digestive diseases; • Engage in scholarly and dynamic discussions of specific clinical topics; and • Engage in scholarly and dynamic discussions of specific investigative topics. Sp605

Sp618

Sp619

Sp620

Sp621

Barrett's Esophagus (M53) Sponsored by the ASGE ETED SIG Nicholas J. Shaheen, Ganapathy A. Prasad

Sp623

Capsule Endoscopy (M38) Sponsored by the ASGE Capsule Endoscopy SIG David E. Fleischer

Sp624

MAY 20

Marriott Hotel & Marina Sp610

Sp625

Sp611

Sp626

Sp627

Sp628

Manchester Hyatt Sp613

Getting the Most Out of Capsule Endoscopy (M47) Blair S. Lewis, Daniel S. Mishkin 33BC

San Diego Convention Center Sp614

Hereditary GI Cancer Syndromes (M37) Randall W. Burt

Madeline B Manchester Hyatt

Sp615

P-96

IBD and Colorectal Cancer (M41) Steven H. Itzkowitz

Madeline C Manchester Hyatt

Optimizing Your Endoscopic Practice (M48) Sponsored by the ASGE AEC SIG Carlsbad (South Tower) Klaus Mergener, Frank J. Chapman Re-Classifying Acute Pancreatitis (M52) Michael G. Sarr The DAVE Project (M45) Peter B. Kelsey

30D San Diego Convention Center

Update On Intrahepatic Cholestasis of Pregnancy (M40) J Eileen Hay Balboa (South Tower)

Marriott Hotel & Marina Sp629

ERCP Cases (M34) John Baillie, Robert A. Enns

Gastrointestinal Motility Disorders in Children (M43) Raj Kapur Madeline D

NOTES Update (M54) Lee L. Swanstrom, Silvana Perretta

26B San Diego Convention Center

30B San Diego Convention Center

Sp612

Natural Orifice Transgastric Endoscopic Surgery (M42) Anthony N. Kalloo 33A

Marriott Hotel & Marina

Dyspepsia: Pathogenesis and Management (M55) Nicholas J. Talley Ford C

Manchester Hyatt

Ford A Manchester Hyatt

30A San Diego Convention Center

30C San Diego Convention Center

Diagnosis and Managment of Hepatorenal Syndrome (M39) Pere Gines Oceanside (South Tower)

Microscopic Colitis (M50) Darrell S. Pardi, Corey A. Siegel

San Diego Convention Center

30E San Diego Convention Center

T U E S D A Y

Medical and Surgical Therapy for Fecal Incontinence (M57) Emma C William E. Whitehead

Manchester Hyatt

Participants will be able to: • Identify new scientific and clinical information relevant to digestive diseases; • Engage in scholarly and dynamic discussions of specific clinical topics; and • Engage in scholarly and dynamic discussions of specific investigative topics.

Sp609

Managing UGI Bleeding (M49) Newport Beach (South Tower) David C. Metz

Marriott Hotel & Marina

Sp622

Sp608

Managing Local Complications of Necrotizing Pancreatitis (M35) Todd H. Baron, Dia T. Simmons Madeline A

Manchester Hyatt

DDW Meet-the-Professor Luncheons 12:30 PM - 1:45 PM

Sp607

Liver Transplantation (M36) Carl L. Berg, Michael Volk Greenroom (South Tower)

Marriott Hotel & Marina

Enteric Nervous System and Inflammation (M33) Gary M. Mawe Del Mar (South Tower)

Marriott Hotel & Marina

Liver Disease in Children with Intestinal Failure (M44) Deirdre Kelly Pacific (South Tower)

Marriott Hotel & Marina

Creating Databases in IBD (M32) Subra Kugathasan, David G. Binion

31A San Diego Convention Center

Sp606

Laparoscopic Hepatectomy (M46) Alan Koffron

Using Laboratory Test for IBD in Clinical Practice (M56) Severine Vermeire Emma B

Manchester Hyatt Sp630

What to Do About Refractory GERD (M51) Joel E. Richter, Marcelo F. Vela

Ford B Manchester Hyatt

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Problem-Based Learning Luncheons 12:30 PM - 1:45 PM

Participants will be able to: • Interact in a small group setting to define facts, develop hypotheses, and determine a learning agenda; • Increase participant's current knowledge of interesting gastrointestinal disease and issues; and • Evaluate this method of teaching with respect to achieving the session's objectives. Sp631

36 Year Old Patient with Heartburn and Not Responding to High Dose PPI Therapy (LL03) Edward B Prateek Sharma, Peter Malfertheiner

2:30 #679

Who Should Do NOTES: Initial Endoscopic Performance and Early Learning Curve of Laparoscopic Surgeons in Comparison to Endoscopists and Untrained Individuals Oliver J. Wagner*, Monika E. Hagen, Francois Pugin, Philippe Morel, Daniel Candinas

2:45 #680

To Prepare or Not the Colon for Elective Surgery with Primary Intraperitoneal Anastomosis. There Is No Question María Jesús Peña-Soria, Julio M. Mayol*, Rocio Anula, Ana M. Arbeo-Escolar, Jesus A. Fernandez-Represa

3:00 #681

Routine Liver Biopsy to Detect Non-Alcoholic Fatty Liver Disease (NAFLD) During Laparoscopic Cholecystectomy for Symptomatic Gallstone Disease (GD). Is It Justified? Antonio Ramos-De la Medina*, Federico B. Roesch, Alfonso Perez Morales, Silvia Cid-Juarez, Jose M. Remes-Troche

3:15 #682

Reinterventions for Specific Technique-Related Complications of Stapled Haemorrhoidopexy (SH): A Critical Appraisal Pierpaolo Sileri*, Vito M. Stolfi, Antonio Chiaravalloti, Achille Lucio Gaspari

Manchester Hyatt Sp632

An Evidence Based Approach to the Management of Irritable Bowel Syndrome (LL10) Betsy C Philip S. Schoenfeld

Manchester Hyatt Sp633

Cut By Ockham's Razor: Man with Multiple Causes of Obscure GI Bleeding (LL09) Eric M. Goldberg Edward D

Manchester Hyatt Sp634

Evaluating and Negotiating Physician Employment Contracts (LL06) J. Sumner Bell, F. Taylor Wootton, III Edward A

Manchester Hyatt Sp635

Unresponsive GERD Versus Eosinophilic Esophagitis in a 15 Year Old Male (LL08) Edward C Laurie N. Fishman

Manchester Hyatt ASGE Fellows Luncheon 12:30 PM - 2:00 PM

Marriott Hall, Salon 4 Marriott Hotel & Marina

ASGE FELLOWS LUNCHEON Participants will be able to: • Engage in a roundtable discussion with ASGE governing board and ASGE training committee members.

SSAT Plenary Session 2:15 PM - 3:30 PM

28ABC San Diego Convention Center

Chairs: Susan Galandiuk, Thomas H. Magnuson SSAT PLENARY SESSION V Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 2:15 #678

DDW Combined Clinical Symposium 2:15 PM - 3:45 PM 20A San Diego Convention Center Chairs: William E. Whitehead, Tracy L. Hull Sponsored by: AGA Institute; SSAT

FECAL INCONTINENCE - NEW PERSPECTIVES ON EARLY DETECTION, CURRENT AND FUTURE THERAPIES Participants will be able to: • Make the audience aware of the prevalence of fecal incontinence and how often it remains undiagnosed; • Identify modifiable risk factors and strategies for prevention; and • Show the impact of fecal incontinence on quality of life and health care cost. 2:15 Sp636

Epidemiology, GI Disease Risk Factors, and Recommendations of the NIH State of the Science Conference On the Prevention of Fecal and Urinary Incontinence Frank A. Hamilton

2:33 Sp637

Quality of Life Impact Nancy J. Norton

2:51 Sp638

Pathophysiology and New Diagnostic Tests Adil E. Bharucha

3:09 Sp639

Medical Management and Biofeedback Steve Heymen

3:27 Sp640

Surgical Management Ann C. Lowry

T U E S D A Y MAY 20

NOTES Rectosigmoid Resection Using Transanal Endosocopic Microsurgery (TEM) with Transgastric Flexible Endoscopic Assistance: A Pilot Study in Swine Patricia Sylla*, Field F. Willingham, Denise W. Gee, William R. Brugge, David W. Rattner

P-97

ORAL SESSIONS—SCIENTIFIC SESSIONS DDW Combined Clinical Symposium 2:15 PM - 3:45 PM 20BCD San Diego Convention Center Chairs: Douglas O. Faigel, James M. Scheiman Sponsored by: ASGE; AGA Institute

MANAGING THE ENDOSCOPY PATIENT ON ANTICOAGULANT/ANTIPLATELET THERAPY 2:15 Sp641

Anticoagulation 101: Update for the Endoscopist Tom DeLoughery

2:45 Sp642

Coronoray Stents, Plavix and the Endoscopic Patient Ori Ben-Yehuda

3:15 Sp643

Managing Anticoagulation and Antiplatelet Agents in the Endo Unit: Guidance from the Guidelines Todd H. Baron

2:20 Sp648

SRTR Data On MELD Upgrades and Analysis of Changes 2005-2007 John Magee

2:40 Sp649

Rational for MELD Upgrade Points for Specific Conditions Richard B. Freeman

3:00 Sp650

Transplant Benefit - the Future of MELD Upgrades John R. Lake

3:20 Sp651

Results of Message Meeting - the Past, the Present, the Future Robert G. Gish

3:40

Wrap-Up

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM 2 San Diego Convention Center Chairs: Michael J. Bourke, Paul Fockens

AASLD Clinical Symposium 2:15 PM - 3:45 PM

6DE San Diego Convention Center

ADVANCES IN COLONOSCOPY IMAGING AND TECHNOLOGY

Chairs: Paul Martin, Andrew Muir HCV TREATMENT IN PATIENTS WITH RENAL FAILURE Participants will be able to: • Assess the implications of HCV infection in renal transplant candidates; • Identify candidates for antiviral therapy in the Chronic Kidney Disease population; and • Evaluate HCV infected patients for renal manifestations of viral infection. 2:15

T U E S D A Y MAY 20

Welcome and Introduction

2:20 Sp644

Transmission and Prevention of HCV in the Chronic Kidney Disease (CKD) Population Miriam J. Alter

2:40 Sp645

Assessment of Liver Disease Due to HCV in the CKD Population K. Rajender Reddy

3:00 Sp646

HCV and Renal Transplant Paul Martin

3:15 Sp647

Treatment of HCV in the CKD Population Andrew Muir

3:30

2:15 Sp652

Smart Biopsy Colonoscopy Ralf Kiesslich

2:38 Sp653

CT Colonography Don C. Rockey

3:01 Sp654

Emerging Colonoscope Technologies Glenn M. Eisen

3:23 Sp655

Capsule Colonoscopy Jacques M. Deviere

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM 6A San Diego Convention Center Chairs: Amit Rastogi, Philip S. Schoenfeld Sponsored by: Clinical Practice; Growth, Development & Aging ; Gastrointestinal Oncology

“BEST PRACTICES” IN CRC SCREENING WITH COLONOSCOPY

6F San Diego Convention Center

Chairs: Robert G. Gish, John R. Lake MELD EXCEPTIONS Participants will be able to: • Understand the MELD allocation system; • Understand which diseases are not addressed by MELD or not fully included in the MELD score; and • Review the main MELD exception diagnosis and how to evaluate and present patients to their regional transplant program to potentially gain additional points for their disease state.

P-98

Participants will be able to: • Appreciate advances in colonoscopic imaging; and • Be familiar with emerging endoscope technologies.

Panel Discussion

AASLD Clinical Symposium 2:15 PM - 3:45 PM

2:15

Sponsored by: Imaging & Advanced Technology; Clinical Practice; Gastrointestinal Oncology; Intestinal Disorders

Welcome and Introduction

Participants will be able to: • Review RCT data about the efficacy and safety of different colonoscopy preparations; • Discuss the use of new endoscopic polypectomy devices and advantages/disadvantages of these devices; and • Identify techniques to minimize post-polypectomy bleeding.quantify data that should be recorded during each colonoscopy for quality assurance. 2:15 Sp656

“Best Practices” in Polypectomy: What Are the New Devices? Todd H. Baron

2:38 Sp657

“Best Practices” in Colon Prep: PEG, Sodium Phosphate, New Combinations? David H. Balaban

ORAL SESSIONS—SCIENTIFIC SESSIONS 3:01 Sp658

“Best Practices” in Preventing Endoscopic Complications: How Can We Minimize PostPolypectomy Bleeding? Douglas K. Rex

AGA Institute Research Symposium 2:15 PM - 3:45 PM 31A San Diego Convention Center

3:23 Sp659

“Best Practices” in Endoscopic Center Management: What Data Should Be Recorded and Documented? Grace H. Elta

Chairs: Richard S. Blumberg, Stephen J. Keely

AGA Institute Research Symposium 2:15 PM - 3:45 PM 33BC San Diego Convention Center Chairs: Jean Marie Houghton, Rhonda F. Souza Sponsored by: Esophageal, Gastric & Duodenal Disorders; Clinical Practice; Gastrointestinal Oncology; Growth, Development & Aging

A PHOENIX ARISING FROM THE FIRE: INFLAMMATIONINDUCED CANCER IN THE UGI TRACT Participants will be able to: • Recognize role(s) of inflammation in UGI tract malignancy; • Describe host and microbial factors in UGI cancer; and • Learn about models of inflammatory cancers. 2:15 Sp660

Lessons Learned from Helicobacter pylori Steffen Backert

2:45 Sp661

Translational Models of Inflammatory Cancers Andrew S. Giraud

3:15 Sp662

How Do Cancers Arise Within Barrett's Esophagus? Rebecca Fitzgerald

Sponsored by: Intestinal Disorders; Immunology, Microbiology & Inflammatory Bowel Disease; Hormones, Transmitters, Growth Factors, & Their Receptors

HYPOXIA AND IBD Participants will be able to: • Describe the role of vasculature in IBD; • Identify the contribution of hypoxia to the development of IBD and the implications of hypoxia on NFkB signaling in IBD; and • Explain the role of pseudomonas in the regulation of HIF. 2:15 Sp666

Hypoxia, HIF and Inflammation in IBD Sean P. Colgan

2:38 Sp667

Hypoxia and NFkB in IBD Cormac T. Taylor

3:01 Sp668

The Vasculature and IBD David G. Binion

3:23 Sp669

HIF and Pseudomonas John C. Alverdy

AGA Institute Research Symposium 2:15 PM - 3:45 PM 32AB San Diego Convention Center Chairs: Gyorgy Baffy, Richard M. Green

AGA Institute Research Symposium 2:15 PM - 3:45 PM 30E San Diego Convention Center

Sponsored by: Nutrition & Obesity; Immunology, Microbiology & Inflammatory Bowel Disease; Intestinal Disorders; Hormones, Transmitters, Growth Factors, & Their Receptors; Liver & Biliary

Chairs: Robert O. Heuckeroth, Judith Eisen

INFLAMMATION AND ADIPOSITY IN GASTROINTESTINAL AND LIVER DISEASE

Sponsored by: Growth, Development & Aging; Esophageal, Gastric & Duodenal Disorders; Neurogastroenterology and Motility; Hormones, Transmitters, Growth Factors, & Their Receptors

ENTERIC NERVOUS SYSTEM DEVELOPMENT: MODELING COMPLEX MULTIGENIC HUMAN DISEASE Participants will be able to: • Learn the genes that influence enteric nervous system development; • Identify the role of growth factors in nervous system development; and • Summarize developmental patterns of enteric neurons. 2:15 Sp663

Morphogens and Growth Factors in Enteric Nervous System Development Robert O. Heuckeroth

2:45 Sp664

Molecular Genetics of Enteric Nervous System Development Michelle Southard-Smith

3:15 Sp665

Zebrafish As a Model for Enteric Nervous System Development Judith Eisen

Participants will be able to: • Describe the emerging role of adipocytokines and visceral adipose tissue in intestinal diseases; and • Discuss how inflammation and adiposity/obesity affect gastrointestinal and liver disease. 2:15 Sp670

UCP2 At the Crossroads of Energy Metabolism, Inflammation and Tumorigenesis Gyorgy Baffy

2:45 Sp671

Adipocytokines and Visceral Adipose Tissue: Emerging Role in Intestinal Diseases Andreas Schaeffler

3:15 Sp672

Inflammation and Adiposity/Obesity Haiyan Xu

T U E S D A Y MAY 20

P-99

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Symposium 2:15 PM - 3:45 PM 3 San Diego Convention Center Chairs: Duyen Dang, John P. Lynch Sponsored by: Gastrointestinal Oncology; Hormones, Transmitters, Growth Factors, & Their Receptors; Esophageal, Gastric & Duodenal Disorders; Neurogastroenterology and Motility

PROTEIN KINASES AND GI CANCERS Participants will be able to: • Identify the role of protein kinases in GI cancers; and • Explain the various protein kinases that are altered in GI cancers.

Questions & Answers

ASGE Clinical Symposium 2:15 PM - 3:45 PM

11 San Diego Convention Center

Chairs: Thomas J. Savides, Mohamad A. Eloubeidi HOT TOPICS IN EUS 2:15 Sp685

Interventional Biliary EUS Michel Kahaleh

Kinomics and Cancer Tony Hunter

2:35 Sp686

Therapeutic Pancreatic EUS William R. Brugge

2:45 Sp674

SRC Signaling in GI Cancer Chris Cartwright

2:55 Sp687

EUS Angiography Sergey V. Kantsevoy

3:15 Sp675

BRK/Sik Signaling in Colon Cancer Angela L. Tyner

Chairs: George Webster, Suresh T. Chari Sponsored by: Pancreatic Disorders; Imaging & Advanced Technology ; Clinical Practice; Nutrition & Obesity

AUTOIMMUNE PANCREATITIS AND CHOLANGIOPATHY: SPECTRUM OF AN EMERGING CLINICAL DISORDER Participants will be able to: • Comprehend the clinical presentation, endoscopic features, histopathology, diagnostic criteria and management of autoimmune pancreatitis and cholangiopathy.

MAY 20

3:30

Challenging Cases: What Would the Experts Do? Prateek Sharma

2:15 Sp673

AGA Institute Translational Symposium 2:15 PM - 3:45 PM 31BC San Diego Convention Center

T U E S D A Y

3:15 Sp684

2:15 Sp676

Distinguishing PSC and Autoimmune Cholangiopathy Keith D. Lindor

2:38 Sp677

Endoscopic Findings in the Pancreas and Biliary Tree Michael J. Levy

3:01 Sp678

Histopathology: Making the Diagnosis with Tissue Vikram Deshpande

3:23 Sp679

Who, How and When to Treat Suresh T. Chari

ASGE Clinical Symposium 2:15 PM - 3:45 PM

6C San Diego Convention Center

3:15

AGA Institute Late-Breaking Abstract Session 2:15 PM - 3:45 PM 29 San Diego Convention Center Chairs: William D. Chey, Nicholas J. Shaneen Sponsored by: AGA Institute Council

LATE BREAKING ABSTRACT SESSION 2:15 #682a

High Resolution Confocal Endomicroscopy Probe System for in vivo Diagnosis of Colorectal Neoplasia Anna Buchner

2:30 #682b

Chemopreventive Effectiveness of Celecoxib Two Years After Cessation of Treatment Nadir Arber

2:45 #682c

A Randomized Trial of Methotrexate (MTX) in Combination with Infliximab (IFX) for the Treatment of Crohn's Disease (CD) Brian Feagan

3:00 #682d

A Computer-Assisted Personalized Sedation System to Administer Propofol versus Standard of Care Sedation for Colonoscopy and EGD: A 1000 Subject Randomized, Controlled, Multi-Center, Pivotal Trial Daniel Pambianco

3:15 #682e

Asimadoline in the Treatment of IBS Allen Mangel

3:30 #682f

Linaclotide Significantly Improved Bowel Habits and Relieved Abdominal Symptoms in Adults with Chronic Constipation: Data from a Large Four-week, Randomized, Double-blind, Placebo-controlled Study Anthony Lembo

Chairs: Richard E. Sampliner, Prateek Sharma ENDOSCOPIC ABLATION THERAPY FOR BARRETT'S ESOPHAGUS 2:15 Sp680

Endoscopic Ablation: Patient Selection Gary W. Falk

2:30 Sp681

Improving the Histological Diagnosis of Barrett's Neoplasia John R. Goldblum

2:45 Sp682

Endoscopic Resection: Diagnostic or Therapeutic? Christian Ell

3:00 Sp683

Mucosal Ablation Techniques Richard E. Sampliner

P-100

Questions & Answers

AASLD Research Forum 2:15 PM - 3:45 PM

7A San Diego Convention Center

Chairs: Sundararajah Thevananther, TBD HEPATOCYTE AND STEM CELL BIOLOGY 2:15 #683

Hepatocyte Priming and Proliferation in Response to Partial Hepatectomy Is Impaired in the eNOS Knockout Mice Yu Mei*, Hongdan Sun, Bryan Tackett, Sundararajah Thevananther

ORAL SESSIONS—SCIENTIFIC SESSIONS 2:30 #684

C133+ Liver Cancer Stem Cells from Methionine Adenosyl Transferase 1A Deficient Mice Demonstrate Resistance to TGF-β Induced Apoptosis Carl B. Rountree*, Wei Ding, Shelly C. Lu

2:45 #685

Glial Fibrillary Acidic Protein(+) Progenitors Regenerate Adult Livers Liu Yang*, Youngmi Jung, Jiawen Huang, Alessia Omenetti, Rafal P. Witek, Steve S. Choi, Gianfranco Alpini, Anna Mae Diehl

3:00 #686

3:15 #687

3:30 #688

Extracellular ATP and Activation of P2y2-Purinergic Receptors Play Key Roles in the Induction of Early Growth Response-1 (Egr-1) in Regenerating Liver Bryan Tackett*, Yu Mei, Hongdan Sun, Sundararajah Thevananther Hepatic Stellate Cells Modulate the Differentiation of Bone Marrow Mesenchymal Stem Cells Into HepatocyteLike Cells Xing Deng*, Wei-Fen Xie, Yue-Xiang Chen, Xin Zhang Highly Efficient Differentiation of Human Embryonic Stem Cells to Metabolically Active Hepatocytes In Vitro and In Vivo David C. Hay*, Judy Fletcher, Catherine Payne, John Terrace, Ronald Gallagher, James R. Black, Anne Pryde, Celine Filippi, Stuart J. Forbes, Kay Samuel, James A. Ross, John P. Iredale, Philip Newsome

AGA Institute Research Forum 2:15 PM - 3:45 PM

4 San Diego Convention Center

3:30 #694

AGA Institute Research Forum 2:15 PM - 3:45 PM

FOOD INTAKE, OBESITY AND BRAIN-GUT INTERACTIONS Participants will be able to: • Learn about the effects of neuropeptides on food intake; and • Learn about the role of gastric emptying and food intake. 2:15 #689

des-acyl Ghrelin Inhibits the Orexigenic Effect of Peripherally Injected Ghrelin Andreas Stengel*, Peter Kobelt, Tobias Inhoff, Steffen Noetzel, Anna-Sophia Wisser, Miriam Goebel, Bertram Wiedenmann, Burghard F. Klapp, Yvette Tache, Hubert Monnikes

2:30 #690

Leptin Signaling Is Required for CCK Regulation of Satiety But Not Pancreatic Secretion: Differential Distribution of High and Low Affinity CCK-a Receptors in the Nodose Ganglia Chung Owyang*, Yibai Hao, Ying Li

2:45 #691

Switching of Leptin Effects On Peripheral Vagal Afferent Mechanosensitivity with Feeding and Fasting Amanda J. Page*, Tracey A. O'Donnell, Laura Koch, Stuart M. Brierley, L. Ashley Blackshaw

3:00 #692

Effect of Sibutramine On Gastric Emptying and Body Composition and the Role of Candidate Genes in 181 Obese or Overweight Patients Seth R. Sweetser*, April Grudell, Paula Carlson, Duane D. Burton, Maria Vazquez Roque, Deborah J. Eckert, Autumn Braddock, Matthew Clark, Karen Graszer, Sarah Kalsy, Alan R. Zinsmeister, Michael Camilleri

3:15 #693

Is It Feasible to Measure Gastric Tone and Antral Contractions with Magnetic Sensors As An Implantable Device? Hongbing Zhu*, Yong Lei, Jiande Chen

26B San Diego Convention Center

Chairs: George H. Greeley, Jorg Glatzle Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

HORMONES, RECEPTORS AND INFLAMMATORY EVENTS IN THE EPITHELIUM Participants will be able to: • Learn about receptor regulation in intestinal inflammation and infection; and • Understand the mechanisms underlying the development of inflammation. 2:15 #695

The Glucocorticoid Receptor Gene Polymorphism Bcli Which Modulates Glucocorticoid Sensitivity Is Associated with Inflammatory Bowel Disease Manon J. van Oosten*, Christien J. van der Woude, Rinse K. Weersma, Elisabeth F. van Rossum, Jan W. Koper, Ernst J. Kuipers, Steven Lamberts, Richard A. Feelders

2:30 #696

Genetic Disruption of the Murine Glucagon-Like Peptide 2(GLP-2) Receptor Increases Susceptibility to Indomethacin-Induced Enteritis Kunmin K. Li*, Seung-Jun Lee, Daniel J. Drucker

2:45 #697

Nematode-Generated Serine Proteases Interact with Host PAR-2 to Alter Epithelial Cell Function Jennifer A. Stiltz*, Rao N. Jaladanki, Sarah Netzel-Arnett, Toni Antalis, Rex Sun, Joseph F. Urban, Aiping Zhao, Terez Shea-Donohue

3:00 #698

Critical Role of the Alpha-7 Nicotinic Acetylcholine Receptor in the Development of Colitis Jean-Eric Ghia*, Patricia Blennerhassett, Amber J. Park, Yikang Deng, Ryan Cornell, Stephen M. Collins

3:15 #699

Deficiency in Proteinase-Activated Receptor-2 (PAR2) Attenuates Colonic Inflammation in Mice Independent of Bone Marrow Derived Cells Eric Hyun*, Patricia Andrade-Gordon, Nathalie Vergnolle

3:30 #700

Perturbation, Not Complete Lack of CRF Receptor 2 Leads to Increased Susceptibility to Colitis Min Liao, Julia Hoy, Mary P. Stenzel-Poore, Aditi Bhargava*

Chairs: Christine Feinle-Bisset, Michael Camilleri Sponsored by: Neurogastroenterology and Motility

Effects of Probiotics On Gut-Brain Axis During Chronic H. pylori Infection Premysl Bercik*, Elena F. Verdu, Jane Foster, XianXi Huang, Angela Scharringa, Jun Lu, Thomas A. Tompkins, Stephen M. Collins

T U E S D A Y MAY 20

P-101

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 2:15 PM - 3:45 PM

6B San Diego Convention Center

Chairs: John E. Pandolfino, Marcelo F. Vela

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

Sponsored by: Esophageal, Gastric & Duodenal Disorders

Participants will be able to: • Become familiar with the potential role of phosphatidylcholine for the treatment of ulcerative colitis; • Become familiar with the potential role of anti-beta7 antibody for the treatment of ulcerative colitis; and • Become familiar with the potential role of anti-ip10 antibody for the treatment of ulcerative colitis. 2:15 #701

2:30 #702

2:45 #703

MAY 20

33A San Diego Convention Center

Chairs: Brian Feagan, Jean-Frédéric Colombel

ADVANCES IN THE TREATMENT OF ULCERATIVE COLITIS

T U E S D A Y

AGA Institute Research Forum 2:15 PM - 3:45 PM

3:00 #704

3:15 #705

3:30 #706

P-102

A Randomized, Double-Blind, Placebo-Controlled Trial of a Probiotic Preparation, Vsl#3, for the Treatment of Mild to Moderate Active Ulcerative Colitis Govind K. Makharia*, Ajit Sood, Vandana Midha, Vineet Ahuja, Dinesh K. Singal, Reenu Arora, Shaman Sood, Pooja Goswami, Claudio De Simone, Aditya R. Sahu, Rakesh K. Tandon Efficacy and Safety of Delayed-Release Oral mesalamine At 4.8g/D (800mg Tablet) in the Treatment of Moderately Active Ulcerative Colitis: Results of the Ascend III Study William J. Sandborn*, Jaroslaw Regula, Brian Feagan, Elena A. Belousova, Njegica V. Jojic, Milan -. Lukas, Bruce R. Yacyshyn, Piotr Krzeski, Chyon-Hwa Yeh, Stephen B. Hanauer Gut-Homing CD4+ Lymphocytes Are Specifically Targeted in Cynomolgus Monkeys Dosed with AntiBeta7 Antibodies Franklin Fuh, Clarissa David, Olivia Hwang, Shweta Gadkari, Quyen Nguyen, Chikara Takahashi, Jeffery Lutman, Khanh Pham, Anahid Storn, Kathleen Howell, Karen Berry, Sharon O'Byrne, Dimitry M. Danilenko, Thomas Gelzleichter, Hong Wang, Eric Stefanich, Marna Williams* A Phase 1 Open-Label, Single-Dose, Dose-Escalation Study of Mdx-1100, a High-Affinity, Neutralizing, Fully Human Igg1κ Anti-CXCL10 (Ip10) Monoclonal Antibody, in Ulcerative Colitis Robert Hardi*, Lloyd Mayer, Stephan R. Targan, Michael Yellin, Pina M. Cardarelli, Kiron M. Das New Insights of Anti-Depressant Therapy in the Management of Ulcerative Colitis (UC) Abbas Esmaeili*, M. Masjedi, Alireza Ani, Ziba Farajzadegan, A. Behbahani, M. Dashti, Mohammad Hasan Emami Retarded Release Phosphatidylcholine in Non-SteroidTreated Ulcerative Pancolitis: A Randomized, Controlled Dose Finding Study Wolfgang Stremmel*, Annika Braun, Anja Hanemann, Frank Autschbach, Robert Ehehalt, Max Karner

INSIGHTS INTO GERD DIAGNOSTIC TESTING Participants will be able to: • Evaluate recent research on diagnostic testing. 2:15 #707

Evaluation of the Proton Pump Inhibitor (PPI) Test for the Diagnosis of GERD: Results from the Diamond Study Peter Bytzer*, Roger Jones, Nimish Vakil, Ola Junghard, Tore Lind, John Dent

2:30 #708

Ambulatory 24-H pH-Impedance Monitoring in Patients with Therapy-Resistant Reflux Symptoms: ‘On' or ‘Off' Proton Pump Inhibitor? Gerrit J. Hemmink*, Albert J. Bredenoord, Bas L. Weusten, Jan F. Monkelbaan, Robin Timmer, Andreas J. Smout

2:45 #709

Inter-Observer Agreement for Multi-Channel Intraluminal Impedance-pH (MII-pH) Testing Karthik Ravi*, Dawn L. Francis, Joseph a. Murray, Ernest P. Bouras, Kenneth R. DeVault

3:00 #710

Gastrin-17 (G-17): A Serological Bio-Marker for Diagnosis of Gastro-Esophageal Reflux Disease (GERD) Ester Morana, Loredana Guida, Lucas Giovanni Cavallaro, Roberta Merli, Raffaella Alessia Zuppardo, Giulia Martina Cavestro, Alberto Pilotto, Marilisa Franceschi, Andrea Iori, Margherita Curlo, Andrea Maini, Angelo Franzè, Francesco Di Mario*

3:15 #711

Is Esophageal Impedance Monitoring Detecting Something New? a Case-Control Study Assessing Predictive Nature of Non-Acid Reflux Jason M. Pritchett*, James C. Slaughter, Michael F. Vaezi

3:30 Sp688

GERD Diagnostic Testing in 2008: When, How and Who Should Be Tested? Marcelo F. Vela

AGA Institute Research Forum 2:15 PM - 3:45 PM

30C San Diego Convention Center

Chairs: Terence K. Smith, Mira Wouters Sponsored by: Neurogastroenterology and Motility

INTERSTITIAL CELLS OF CAJAL: TROPHIC FACTORS AND PLASTICITY Participants will be able to: • Understand the factors that control ICC development and numbers; and • Understand the role of ICC in gastrointestinal motility. 2:15 #712

Bone-Marrow Cells Are Able to Develop Interstitial Cells of Cajal: Morphologic Evidences in W/WV Mice Shuji Ishii*, Shingo Tsuji, Masahiko Tsujii, Jumpei Kondo, Sachiko Nakajima, Toshiyuki Yoshio, Shinichiro Shinzaki, Satoshi Egawa, Tsutomu Nishida, Yoshimi Kakiuchi, Kenji Watabe, Hideki Iijima, Sunao Kawano, Norio Hayashi

2:30 #713

Nitric Oxide Is Important for Maintaining Structure and Functional Integrity of Interstitial Cells of Cajal: Mediation By Stem Cell Factor/Ckit Pathways Ning Zou*, Shi-Yi Zhou, Chung Owyang

ORAL SESSIONS—SCIENTIFIC SESSIONS 2:45 #714

Stimulation of the 5-HT2b Receptor On ICC Activates Calcium Dependent Protein Kinase Cs to Induce Proliferation Mira Wouters*, Vivek S. Tharayil, Jaime L. Roeder, Peter R. Strege, Simon J. Gibbons, Gianrico Farrugia

3:00 #715

The Role of Kit Positive Cells in Development of GI Motility in the Zebrafish Adam J. Rich*, Chris R. Brown, Scott M. Gordon, Mark P. Heitz, Grant W. Hennig, Gianrico Farrugia

3:15 #716

3:30 #717

Distribution of Interstitial Cells of Cajal in the Primate Rectoanal Region and Their Relationship to Sympathetic and Nitrergic Nerves Caroline A. Cobine*, Yulia Bayguinov, Sean M. Ward, Kathleen Keef A Reduced Density of Interstitial Cells of Cajal Predict Small Intestinal Bacterial Overgrowth in a Rat Model of Post-Infectious IBS Secondary to Campylobacter Jejuni Walter Morales*, Amy L. Zhu, Venkata B. Pokkunuri, Christopher Chang, Kimberly Low, Sam-Ryong Jee, Edy E. Soffer, Jeffrey L. Conklin, Mark Pimentel

AGA Institute Research Forum 2:15 PM - 3:45 PM

30B San Diego Convention Center

AGA Institute Research Forum 2:15 PM - 3:45 PM

Chairs: Ikuo Hirano, Glenn T. Furuta Sponsored by: Esophageal, Gastric & Duodenal Disorders

NEW INSIGHTS IN EOSINOPHILIC ESOPHAGITIS Participants will be able to: • Learn mechanisms, interventions and therapy for eosinophilic esophagitis (EoE). 2:15 #724

A Critical Role of Interleukin-15 in the Pathogenesis of Eosinophilic Esophagitis Anil Mishra*, Meiqin Wang, Philip E. Putnam, Marc E. Rothenberg

2:30 #725

Periostin Facilitates Eosinophil Tissue Infiltration In Vivo and In Vitro Carine Blanchard*, Melissa K. Mingler, Margaret H. Collins, Philip E. Putnam, Jeffery D. Molkentin, Marc E. Rothenberg

2:45 #726

Budesonide As Induction Treatment for Active Eosinophilic Esophagitis in Adolescents and Adults: A Randomized, Double-Blind, Placebo-Controlled Study (Bee-I Trial) Alex Straumann*, Lukas Degen, Stephanie Felder, Christian Bussmann, Sebastien Conus, Stephan Bucher, Christoph Beglinger, Christina Thalmann, Susanne Portmann, HansUwe Simon

3:00 #727

A Prospective Clinical Trial of Six Food Elimination Diet and Reintroduction of Causative Agents in Adults with Eosinophilic Esophagitis (EE) Nirmala Gonsalves*, Guang-Yu Yang, Bethany Doerfler, Sally Ritz, Anne M. Ditto, Ikuo Hirano

3:15 #728

Dilation in Eosinophilic Esophagitis: Safety, Effectiveness and Impact On Mucosal Inflammation Alain Schoepfer*, Nirmala Gonsalves, Alex Straumann, Ikuo Hirano

3:30 #729

Infliximab, a Monoclonal Antibody to TNF-α, for Severe Eosinophilic Esophagitis in Adults: A Prospective, Translational Pilot-Study Alex Straumann*, Christian Bussmann, Sebastien Conus, Christoph Beglinger, Hans-Uwe Simon

Chairs: Ralph A. Giannella, V.K. Viswanathan Sponsored by: Intestinal Disorders

INTESTINAL MICROBIAL RESPONSE Participants will be able to: • Recognize ion transport alterations associated with Norwalk virus infection; • Recognize how Lactobacillus may alter ion transport; and • Appreciate the role of AKT in regulation of goblet cells. 2:15 #718

2:30 #719

2:45 #720

Enhanced Cytoskeletal Association of Ezrin By ESPF Is Involved in EPEC-Mediated Suppression of NHE3 Activity Kim Hodges*, Krishnamurthy Ramaswamy, Pradeep K. Dudeja, Gail Hecht Mechanisms of Inhibition of Serotonin Transporter (SERT) in Response to Infection By Enteropathogenic E. coli (EPEC) Ali Esmaili*, Alip Borthakur, Saad Nazir, Dan Yu, Jerrold R. Turner, Waddah A. Alrefai, Gail Hecht, Pradeep K. Dudeja, Ravinder K. Gill Dysbiosis and Pouchitis, Evidence from 16srrna Sequencing Simon D. McLaughlin*, liljana petrovska, Alan Walker, Sue K. Clark, Matthew W. Johnson, Paris P. Tekkis, Julian Parkill, Gordon Dougan, Paul J. Ciclitira, Ralph. J. Nicholls

9 San Diego Convention Center

AGA Institute Research Forum 2:15 PM - 3:45 PM

10 San Diego Convention Center

Chairs: Anthony N. Kalloo, Michael L. Kochman Sponsored by: Imaging & Advanced Technology

3:00 #721

The Human Microbiota Inhibits Shiga-Toxin Synthesis By Enterohemorrhagic Escherichia coli Thibaut de Sablet, Christophe Chassard, Annick BernalierDonadille, Marjolaine Vareille, Alain P. Gobert*, Christine Martin

NOTES

3:15 #722

Differential Role of E. coli Secreted Protein F in the Engulfment of Enteropathogenic E. coli By Epithelial Cells and Macrophages Andrew W. Weflen*, Neal M. Alto, V. K. Viswanathan, Gail Hecht

2:15 #733

3:30 #723

Post-Infectious IBS in the “Non-Sterile” Developing Nation Environment and the Role of Parasite Burden, a Population-Based Study in Central America Matthew Benshoff, Eliette Valladares, Rodolfo Pena, Loreto Cortes, Paris . Heidt, Mercedes Caceres, Douglas R. Morgan*

T U E S D A Y MAY 20

Participants will be able to: • Become familiar with natural orifice trans-luminal endoscopic surgery (NOTES). Transoral Gastroplasty (TOGA) for Obesity - Results of Pilot Study Second Phase Christophe Moreno, Gerardo d. Ojeda Valdes, Luis Cuevas Herrera, Jean Closset, Abdellilah Medhi, Pierre Eisendrath, Sonia Dugardeyn, Marie Barea, Olivier Le Moine, Jacques M. Deviere*

P-103

ORAL SESSIONS—SCIENTIFIC SESSIONS 2:30 #734

Next Generation Access and Closure for NOTES: Tissue-Selective Hydro-Dissection for Efficient Gastric Flap Access with Photochemical Tissue Bonding for Secure Closure Marvin Ryou*, Sohail N. Shaikh, Min Yao, Gloria Fernandez-Esparrach, Francis P. Henry, Irene Kochevar, Dan Maurice, Erica L. Matthes, Markus D. Enderle, David L. Carr-Locke, Robert W. Redmond, Christopher C. Thompson

2:45 #735

Use of a Nytinol Crown Prototype for Gastrotomy Closure: Evaluation in An ex vivo Porcine Model Sohail N. Shaikh*, Gloria Fernandez-Esparrach, Christopher C. Thompson

3:00 #736

Could Natural Orifice Transluminal Endoscopic Surgery (NOTES) Ever Be Cost Effective vs. Laparoscopy (Lap)? A Hypothesis Generating Decision Analysis Brennan M. Spiegel*, Jerry O. Jacobson, Eric Esrailian, Matthew D. Solomon

3:15 #737

3:30 Sp689

NOTES Is a Highly Effective Technique for the Evaluation of Acute Penetrating Abdominal Injury Samuel A. Giday*, Xavier Dray, Eun Ji Shin, Jonathan M. Buscaglia, Ronald J. Wroblewski, Jerome Lyn-Sue, Priscilla Magno, Michael R. Marohn, Sergey V. Kantsevoy, Anthony N. Kalloo Look How Far We'Ve Come, Look How Far We Have to Go Robert H. Hawes

AGA Institute Research Forum 2:15 PM - 3:45 PM

28DE San Diego Convention Center

3:15 #742

Modification of Lymphocyte Trafficking in An In Vivo Model of IBD Following Administration of a Novel Alpha 4 Integrin Antagonist Carola Murphy*, Gerard Moloney, Pat Casey, Andrea C. Haynes, Laurens Kruidenier, Andrew Calver, Peter McLean, Kevin Lee, Colin Hill, Liam O'Mahony, Fergus Shanahan, Kenneth Nally

3:30 #743

Rdea119, a Potent and Highly Selective MEK Inhibitor Ameliorates Murine Colitis Marcel Miampamba

AGA Institute Research Forum 2:15 PM - 3:45 PM

Chairs: Waddah A. Alrefai, Lara R. Gawenis Sponsored by: Intestinal Disorders

REGULATION OF INTESTINAL TRANSPORT Participants will be able to: • Review the regulation of intestinal transport. 2:15 #744

Phospholipase Cγ (PLCγ) Directly Binds to the Na+/H+ Exchanger 3 (NHE3) C-Terminus Which Is Necessary for Basal and Calcium-Mediated Inhibition of NHE3 Activity Nicholas C. Zachos*, Damian B. van Rossum, Randen Patterson, Solomon Snyder, Mark Donowitz

2:30 #745

Hydrogen Peroxide Inhibits CA2+-Stimulated Colonic Epithelial Ion Transport Via Activation of Adenosine Monophosphate-Activated Protein Kinase and Inhibition of NKCC1 Alfred E. Chappell, Michael Bunz, Michael Scharl, Christian Lytle, Kim E. Barrett, Declan F. McCole*

2:45 #746

Evidence Against Electrogenicity of Slc26a3 (DownRegulated in Adenoma) Cl-/HCO3- Exchange in Murine Large Intestine Robert Z. Horack, Janet E. Simpson, Nancy M. Walker, Lane L. Clarke*

3:00 #747

Cytosolic Phospholipase a2 Differentially Regulates Calcium and cAMP-Dependent Chloride Secretion in Colonic Epithelial Cells Fergal Donnellan*, Frank E. Murray, Brian M. Harvey, Stephen J. Keely

3:15 #748

Inhibition of Na-Glucose Co-Transport By Prostaglandin E2 Is Mediated By Calcium Calmodulin Kinase-II in Intestinal Epithelial Cells Jamilur R. Talukder*, Steven Coon, Ramesh Kekuda, Uma Sundaram

3:30 #749

Nherf2 Is Necessary for Basal and All Second Messenger Regulation of NHE3 Activity in Intact Mouse Ileal Na Absorptive Cells Rakhilya Murtazina*, Olga Kovbasnjuk, Yueping Chen, Boris M. Hogema, Ursula E. Seidler, Edward J. Weinman, Hugo de Jonge, Mark Donowitz

Chairs: David E. Elliott, Jesus Rivera-Nieves Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

NOVEL THERAPEUTIC AGENTS IN EXPERIMENTAL COLITIS

T U E S D A Y MAY 20

Participants will be able to: • Understand how novel agents that block histone deacetylation influences intestinal inflammation; • Learn how new small molecule inhibitors can block key signaling pathways; and • Understand how soluble α4 integrin anatagonists can interrupt lymphocyte trafficking. 2:15 #738

Histone Deacetylases As Targets in Chronic Intestinal Inflammation Rainer Glauben*, Elena Sonnenberg, Arvind Batra, Thorsten Stroh, Paolo Mascagni, Martin Zeitz, Britta Siegmund

2:30 #739

Oral Chitin Administration Ameliorates Chronic Colitis in TCRα Knockout Mice By Upregulating IFNγProduction and Downregulating Chitinase 3-Like-1 Expression in Mucosal Tissues Katsuya Nagatani, Chun Chuan Chen, Mayumi Kawada, Atsuko Arihiro, Onyinye I. Iweala, Kabir S. Matharu, Cathryn R. Nagler, Emiko Mizoguchi*

2:45 #740

Development of a New Optimized 5-ASA Molecule Ged0507-34 with Intestinal Anti-Inflammatory and Analgesic Properties Christel Rousseaux, Francesca Viti, Caroline Dubuquoy, Salvatore Bellinvia, Jean-Frédéric Colombel, Philippe Chavatte, Pierre Desreumaux*

3:00 #741

4-Oxo-1,4-Dihydroquinoline-3-Carboxamides Derivatives As New Potent and Selective Cb2 Agonists with AntiInflammatory and Analgesic Properties in the Gut Mathilde Body-Malapel*, Jamal El-Bakali, Emilie Mérour, Eric Stern, Régis Millet, Pierre Desreumaux

P-104

26A San Diego Convention Center

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 2:15 PM - 3:45 PM

8 San Diego Convention Center

AGA Institute Research Forum 2:15 PM - 3:45 PM

30D San Diego Convention Center

Chairs: Nadir Arber, David P. Hurlstone

Chairs: Alan L. Buchman, Marvin E. Ament

Sponsored by: Gastrointestinal Oncology

Sponsored by: Nutrition & Obesity

SCREENING AND DIAGNOSIS OF GASTROINTESTINAL CANCERS II

SHORT BOWEL SYNDROME

Participants will be able to: • Learn more about screening and diagnosis in GI cancers. 2:15 #750

Identification of Inherited Predisposition to Colonic Neoplasia Through Partial Wave Spectroscopic Analysis of the Microscopically Normal Colonic Epithelium Hemant K. Roy*, Hariharan Subramanian, Prabhakar Pradhan, Henry T. Lynch, David Weinberg, Zvezdana Bogojevic, Nahla Hasabou, Jennifer Koetsier, Ramesh K. Wali, Stephen J. Lanspa, Michael J. Goldberg, Dhananjay Kunte, Vadim Backman

2:30 #751

Prediction of Colonic Neoplasia Through Spectral Marker Analysis from the Endoscopically Normal Rectum: An ex vivo and In Vivo Study Hemant K. Roy*, Vladimir Turzhitsky, Andrew Gomes, Michael J. Goldberg, Jeremy D. Rogers, Young L. Kim, TatKin Tsang, Dhiren Shah, Monica S. Borkar, Mohammed Jameel, Nahla Hasabou, Randall Brand, Zvezdana Bogojevic, Vadim Backman

2:45 #752

Fluorodeoxyglucose-Positron Emission Tomography Scan (FDG-PET Scan) in the Diagnosis of Colorectal Cancer Recurrence Céline Deleau, Bruno Buecher, Caroline Rousseau, Françoise Kraeber-Bodéré, Stanislas Bruley des Varannes, Jean Paul Galmiche, Tamara Matysiak-Budnik*

3:00 #753

Stool DNA Screening of Colorectal Neoplasia: Improved Adenoma Detection By Novel Digital Melt Curve Assay Hongzhi Zou*, Jonathan J. Harrington, Xuan Jiang, Charles L. Loprinzi, Theodore R. Levin, Douglas K. Rex, Dennis Ahnen, Kandice L. Knigge, Peter . Lance, Daniel J. Sargent, David A. Ahlquist

3:15 #754

3:30 #755

Flow Cytometry in Barrett Esophagus (Cybar Study): A Prospective Cohort Study Marjolein Sikkema*, Marjon Kerkhof, E. W. Steyerberg, Herman van Dekken, Anneke van Vuuren, Han Geldof, Hans van der Valk, Dirk Jan Bac, Raimond Giard, Wilco Lesterhuis, Robert Heinhuis, Elly C. Klinkenberg, Gerrit A. Meijer, Frank T. Borg, Jan-Willem Arends, Jeroen J. Kolkman, Joop van Baarlen, Richard A. de Vries, Andries H. Mulder, Antonie J. Van Tilburg, Johan Offerhaus, Fiebo J. ten Kate, Johannes G. Kusters, E. J. Kuipers, Peter D. Siersema Endoscopic Ultrasonography Is a Valuable Tool with High Yield in Screening of Patients At High-Risk Patients for Pancreatic Cancer Jan-Werner Poley*, Irma Kluijt, Dirk J. Gouma, Anja Wagner, Cora M. Aalfs, Annemieke Cats, Yung Nio, Paul Fockens, Casper H. van Eijck, E. J. Kuipers, Marco Bruno

Participants will be able to: • Define and evaluate recent basic and translational research on the short bowel syndrome. 2:15 #756

Two Dose-Equivalent, 21-Days, Subcutaneous (S.C.), Glucagon-Like Peptide 2 (GLP-2) Dosing Regimens, 1.0 Mg Continuously Versus 0.33 Mg Three Time Daily (tid), in the Treatment of Short Bowel Syndrome (SBS) Patients Palle B. Jeppesen*, Ida B. Gottschalck, Jens J. Holst, Per B. Mortensen, Bolette Hartmann

2:30 #757

Teduglutide, a Glucagon-Like Peptide-2 (GLP-2) Analog, Improves Fluid Balance in Short Bowel Syndrome (SBS) Patients Depending On Parenteral Support (PN) Palle B. Jeppesen*, Bernard Messing, Marek Pertkiewicz, Jane Cyran, Lidia L. Demchyshyn, Ronald Kershner

2:45 #758

Pediatric Short Bowel Syndrome: The Cost of Caring for These Complex Patients Ariel U. Spencer, Debra Kovacevich, Michelle McKinneyBarnett, Christopher J. Maksym, Daniel H. Teitelbaum*

3:00 #759

Low-Dose Glucagon-Like Peptide-2 Augments Intestinal Adaptation and Proglucagon Expression in a Rat Model of MID-Small Bowel Resection Matthew C. Koopmann*, David W. Nelson, Sangita G. Murali, Xiaowen Liu, Mark S. Brownfield, Jens J. Holst, Denise M. Ney

3:15 Sp690

State-of-the-Art Overview Jon Shaffer

ASGE Topic Forum 2:15 PM - 3:45 PM

1 San Diego Convention Center

Chairs: Julia K. LeBlanc, Mohammad R. Anees CLINICAL ENDOSCOPIC ULTRASOUND 2:15 #760

Endoscopic Elastosonography Is Highly Predictive of Definite Pathology Jan-Werner Poley*, E. J. Kuipers

2:27 #761

The Utility of Endoscopic Ultrasound (EUS) in Patients with Barrett's Esophagus (Be) and High Grade Dysplasia (HGD): Analysis of the AIM Dysplasia Trial Experience V. Raman Muthusamy*, Amit Rastogi, Steven A. Edmundowicz, Nicholas J. Shaheen, Prateek Sharma, Kenneth J. Chang

2:39 #762

Endosonographic Evaluation Improves Survival in Patients with Pancreatic Cancer Feng Li*, Ying Zhou, Amitabh Chak, Gregory S. Cooper, Ananya Das

2:51 #763

Endoscopic Ultrasound Guided Fine-Needle Aspiration Biopsy in the Evaluation of Mediastinal Adenopathy Suspected of Extra-Pulmonary Tuberculosis Rajesh Puri*, Peter Vilmann, Sunil Taneja, Randhir Sud, Mandhir Kumar, Kusum Verma

P-105

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS 3:03 #764

A Comparison of the Diagnostic Yield and Specimen Adequacy Between 22 and 25 Gauge Needles for Endoscopic Ultrasound Guided Fine-Needle Aspiration (EUS-FNA) of Solid Pancreatic Lesions (SPL): Is Bigger Better? Thomas Thong H. Nguyen*, Christopher E. Lee, Charles S. Whang, Reiko Ashida, John G. Lee, Kenneth J. Chang, V. Raman Muthusamy

3:15 #765

Routine PET Does Not Alter Nodal Staging in Patients Undergoing EUS-FNA for Esophageal Cancer Rajesh N. Keswani*, Dayna S. Early, Steven A. Edmundowicz, Ramaswamy Govindan, Riad R. Azar

3:27 Sp691

State-of-the-Art Lecture: Endoscopic Ultrasound in 2008 Richard A. Erickson

ASGE Topic Forum 2:15 PM - 3:45 PM

5 San Diego Convention Center

Chairs: Jay J. Bosco, Richard C.K. Wong

SSAT Conference/Debate/Panel/Symposium 2:15 PM - 4:15 PM 24ABC San Diego Convention Center Chairs: Donald E. Low, Michael Choti, John C. Bowen SSAT CONTROVERSIES IN GI SURGERY DEBATE 1: INTRAMUCOSAL ESOPHAGEAL CANCER AND HIGH GRADE DYSPLASIA: WHICH TREATMENT? 2:15 Sp693

Frame the Issue Brant K. Oelschlager

2:20 Sp694

Endoscopic Therapy: Effective and Patient Friendly Drew Schembre

2:30 Sp695

Surgical Therapy: Improved Outcomes and Piece of Mind Jeffrey H. Peters

2:40

DEBATE 2: HEPATOCELLULAR CARCINOMA IN THE MILD CIRRHOTIC: TRANSPLANT OR RESECT?

NOVEL IMAGING IN COLONOSCOPY 2:15 #766

2:27 #767

2:39 #768

T U E S D A Y MAY 20

2:51 #769

Narrow Band Imaging Versus Conventional Colonoscopy for Screening Colonoscopy in a Private Practice Setting A Large Prospective Randomized Trial Andreas Adler*, Timur Yenerim, Jens Aschenbeck, Michael Mayr, Alireza Aminalai, Rolf Drossel, Andreas Schröder, Matthias Scheel, Ioannis S. Papanikolaou, Bertram Wiedenmann, Thomas Roesch Narrow Band Imaging Without High Magnification to Differentiate Polyps During Real-Time Colonoscopy: Improvement with Experience Jason N. Rogart*, Uzma D. Siddiqui, Dhanpat Jain, Tal Oren, Joseph K. Lim, Priya A. Jamidar, Harry R. Aslanian A Prospective Randomized Multicenter Study On the Fujinon Intelligent Colour Enhancement (FICE) System Versus Standard Colonoscopy with Targeted Indigocarmine Chromoscopy: What Is the Impact of Novel Optical Imaging Techniques On Polyp Detection Rates? Juergen Pohl*, Erich Lotterer, Michael F. Sackmann, Martin Medve, Christian Ell Clinical Impact of Wide-Angle, High-Resolution Endoscopy in the Diagnosis of Colorectal Neoplasia in a Non-Selected Population: A Prospective Randomized Controlled Trial maria pellise*, Gloria Fernandez-Esparrach, Andres Cardenas, Oriol Sendino, Elena Ricart, Eva Cristina Vaquero, Antonio Zeben Gimeno-García, Cristina Rodriguez de Miguel, Josep Antoni Bombi, Michel Zabalza, Angels Gines, Josep M. Bordas, Josep M. Pique, Josep Llach, Antoni Castells

3:03 #770

A Prospective Efficacy Evaluation of the Third Eye Retroscope Auxiliary Endoscopy System Jerome D. Waye*, Russell I. Heigh, David E. Fleischer, Jonathan A. Leighton, Leslie B. Aldrich, Jiayi Li, Sanjay Ramrakhiani, Steven A. Edmundowicz, Dayna S. Early, Robert S. Bresalier, William R. Kessler, Douglas K. Rex

3:15 #771

Early Detection of Pre-Malignant Conditions in the Colon By Fluorescence Endoscopy Using Local Sensitization with Hexaminolevulinate (HAL) Brigitte Mayinger*, Florian Neumann, Claudius L. Kastner, Eckhart G. Hahn, Dieter Schwab

3:27 Sp692

P-106

State-of-the-Art Lecture: How Can I Find More Polyps? Gregory S. Cooper

Panel and Audience Discussion

2:55 Sp696

Frame the Issue Michael Choti

3:00 Sp697

Transplant If Eligible Alan W. Hemming

3:10 Sp698

Resection Is Best If Possible Timothy M. Pawlik

3:20

Panel and Audience Discussion DEBATE 3: BEST PRACTICES/CENTERS OF EXCELLENCE: EFFECTIVE TOOLS OR GOOD ADVERTISING?

3:35 Sp699

Frame the Issue Daniel B. Jones

3:40 Sp700

ACS and ASMBS Accreditation: Metrics Drive Quality James K. Champion

3:50 Sp701

Just Another Form of Consumer Marketing Edward L. Felix

4:00

Panel and Audience Discussion

SSAT Quick Shots 3:30 PM - 4:30 PM

28ABC San Diego Convention Center

Chairs: Robert E. Glasgow, Taylor S. Riall SSAT QUICK SHOTS II Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 3:30 #772

Two-Hundred Consecutive Laparoscopic Liver Resections Andrew A. Gumbs*, Brice Gayet

3:37 #773

Long-Term Quality of Life Is Similar After Hepatic Resection for Malignant and Benign Diseases Vanessa Banz*, Regula Fankhauser, Peter Studer, Beat Gloor, Daniel Inderbitzin, Daniel Candinas

ORAL SESSIONS—SCIENTIFIC SESSIONS 3:43 #774

Does Staging Laparoscopy Detect a Higher Rate of Occult Metastases in Patients with Resectable Pancreatic Adenocarcinoma? Carlo M. Contreras*, Robert J. Rettammel, David M. Mahvi, Layton F. Rikkers, Clifford S. Cho, Sharon M. Weber

3:50 #775

Excellent Results from Limited Resection of Duodenal Carcinoid Tumors Kenzo Hirose*, Brown Nancy, Kristina Potanos, Bipan Chand, R. Matthew Walsh

3:57 #776

4:03 #777

Five-Year Outcome of a Randomized Trial Comparing Pylorus- and Duodenum-Preserving Pancreatic Head Resection for Chronic Pancreatitis Ulrich Adam*, Frank Makowiec, Eva Fischer, Tobias Keck, Hartwig Riediger, Ulrich T. Hopt Tailored Transoral Incisionless Fundoplication (TIF) in the Treatment of GERD: The Anatomic and Physiologic Basis for Reconstruction of the Esophagogastric Junction Using a Novel Approach Blair A. Jobe, Ger H. Koek, Stefan J. Kraemer, Barry P. McMahon, Bart Witteman, Flemming H. Gravesen, Cedric S. Lorenzo*, Robert W. O'Rourke, Douglas A. Shumaker, Michael M. Owens, John G. Hunter, Nicole Bouvy

4:10 #779

Signal Detection: A New Statistical Method to Predict NASH in Gastric Bypass Patients John M. Morton*, Gavitt A. Woodard, Tina HernandezBoussard

4:17 #780

Visceral Sensitivity Is Increased During the Initial Development of Postoperative Ileus in Mice Mario H. Mueller*, Mia Karpitschka, Andrej Sibaev, Jörg Glatzle, Bing Xue, Michael S. Kasparek, Martin E. Kreis

4:23 #781

Tissue and Serum Levels of Substance P Correlate in Patients with Chronic Pancreatitis Giuseppe Mascetta, Fabio Francesco di Mola, Federico Selvaggi, Massimo Falconi, Claudio Bassi, Nathalia Giese, Markus W. Buechler, Helmut M. Friess, Pierluigi Di Sebastiano*

SSAT Conference/Debate/Panel/Symposium 3:30 PM - 5:00 PM 25 San Diego Convention Center

AASLD State-of-the-Art-Lecture 4:00 PM - 5:00 PM

6DE San Diego Convention Center

Chair: Nizar N. Zein HIV-VIRAL HEPATITIS CO-INFECTION Participants will be able to: • Describe the effect of HIV on hepatitis B and C; • Understand the issues involving resistance to HBV in HIV patients; and • Learn how to treat HCV in HIV patients. 4:00 Sp705

HIV-Viral Hepatitis Co-Infection Douglas T. Dieterich

DDW Combined Clinical Symposium 4:00 PM - 5:30 PM 20A San Diego Convention Center Chairs: Patrick S. Kamath, Loren A. Laine Sponsored by: AASLD; ASGE; AGA Institute

MANAGEMENT OF GASTRIC AND ECTOPIC VARICES 4:00 Sp706

Pathophysiology, Natural History and Pharmacological Therapy of Gastric and Ectopic Varices Vijay Shah

4:25 Sp707

Endoscopic Therapy for Gastric and Ectopic Varices Roberto DeFranchis

4:45 Sp708

Treatment Beyond Medical and Endoscopic Therapies Thomas D. Boyer

5:05 Sp709

Case Presentation and Panel Discussion Patrick S. Kamath, Loren A. Laine

DDW Combined Clinical Symposium 4:00 PM - 5:30 PM 20BCD San Diego Convention Center

Chairs: David Shibata, Michael J. Stamos

Chairs: Ninh T. Nguyen, Ram Chuttani

Sponsored by: ASCRS

Sponsored by: SSAT; ASGE; AGA Institute

SSAT/ASCRS JOINT SYMPOSIUM: LAPAROSCOPIC RECTAL CANCER SURGERY: IS IT READY FOR PRIME TIME?

OBESITY SURGERY: ENDOSCOPIC AND SURGICAL MANAGEMENT OF COMPLICATIONS

3:30 Sp702

Current State-of-the-Art Conor P. Delaney

3:50 Sp703

Pro: The Time Is Now Jeffrey W. Milsom

4:10 Sp704

Con: Let's Wait for the Data Peter Marcello

4:30

Panel and Audience Discussion

Participants will be able to: • Explain the different types of complications after Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding; and • Discuss the endoscopic and laparoscopic options for management of bariatric complications. 4:00

Welcome and Introductions

4:05 Sp710

Overview of Bariatric Operations Raul J. Rosenthal

4:15 Sp711

Endoscopic Clips, Sutures and Stents for Leaks, Fistule and Stomal Dilation Christopher C. Thompson

4:30 Sp712

Laparoscopic and Endoscopic Management of Band Erosion Santiago Horgan

4:40 Sp713

Endoscopic Balloon Dilation for Gastrojejunal Stenosis Kenneth J. Chang

P-107

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS 4:50 Sp714

Laproscopic and Endoscopic Management of Postoperative GI Bleeding Ninh T. Nguyen

5:00 Sp715

Emerging Endoscopic Bariatric Technologies Ram Chuttani

5:15

Q & A Session

AGA Institute Clinical Symposium 4:00 PM - 5:30 PM 11 San Diego Convention Center Chairs: Gary R. May, Gregory G. Ginsberg Sponsored by: Imaging & Advanced Technology; Clinical Practice; Gastrointestinal Oncology; Esophageal, Gastric & Duodenal Disorders

EMERGING TECHNIQUES IN ENDOLUMINAL RESECTION: BEYOND EMR Participants will be able to: • Become familiar with emerging techniques for endoscopic resection; • Become familiar with their potential and limitations; and • Consider applications in clinical practice.

T U E S D A Y MAY 20

AGA Institute Committee Sponsored Symposium 4:00 PM - 5:30 PM 9 San Diego Convention Center Chairs: John I. Allen, Joel V. Brill Sponsored by: Practice Management & Economics Committee; Clinical Practice & Quality Management Committee

EVALUATING ELECTRONIC MEDICAL RECORDS FOR GASTROENTEROLOGY PRACTICES Participants will be able to: • Learn the basic questions a GI physician should address when considering the selection of an electronic medical record (EMR); • Learn how to successfully implement an EMR once selected; • Understand electronic prescribing and its impact on the GI practice; and • Observe a demonstration of the AGA Institute initiative with Medical Strategic Planning (MSP) to assist physicians in selecting an EMR. 4:00 Sp722a

Overview of the AGA Institute EMR Project John I. Allen

4:18 Sp723

What Should a GI+ASC Practice Look for When Evaluating An EMR? Bruce A. Levy

4:36 Sp727

Applying Practice Specific Objectives to Choosing An EMR - the AGA Institute and MSP InitiativeDemonstration Arthur Gasch

4:00 Sp716

ESD in the US of A Roy M. Soetikno

4:23 Sp717

Flush Knife - East Takashi Toyonaga

4:46 Sp718

Flush Knife - West Thierry Ponchon

4:54 Sp725

How Will Electronic Prescribing Affect the GI Practice? Peter N. Kaufman

5:08 Sp719

Full-Thickness Resection Georg F. Kaehler

5:04 Sp724

Implementation of EMR: The Critical Final Step James S. Leavitt

AGA Institute Clinical Symposium 4:00 PM - 5:30 PM 6A San Diego Convention Center

ASGE Special Session 4:00 PM - 5:30 PM

Chairs: Jerome D. Waye, Ajay Bansal

Chairs: Douglas B. Nelson, Carol A. Burke

Sponsored by: Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Imaging & Advanced Technology ; Neurogastroenterology and Motility

COLONOSCOPY PREPS: WHICH IS THE RIGHT ONE?

NEW “TOOLS AND TRICKS” FOR GI: READY FOR PRIME TIME? Participants will be able to: • Discuss the role of wireless capsule for evaluating GI motility; • Review the techniques and indications for capsule endoscopy in GI diseases; and • List the new techniques for the detection of colon polyps and cancer. 4:00 Sp720

Esophageal Function Testing John E. Pandolfino

4:30 Sp721

Emerging Capsule Technologies Simon Bar-Meir

5:00 Sp722

CRC Screening Made Easier: New Imaging Techniques Paul Fockens

6C San Diego Convention Center

4:00 Sp728

Why Should I Care About Bowel Preparation? Carol A. Burke

4:15 Sp729

Do Sodium Phosphate Preps for Colonoscopy Still Make Sense? Douglas K. Rex

4:35 Sp730

PEG-EIS: Does Low Risk Equal Optimal Prep? Jack A. DiPalma

4:55 Sp731

Grading Prep Quality: Implications for Follow-Up John H. Bond

5:10

Questions & Answers

AASLD Research Forum 4:00 PM - 5:30 PM

7B San Diego Convention Center

Chairs: Hashem B. El-Serag, Shelly C. Lu HEPATOBILIARY CARCINOMA 4:00 #782

P-108

Utilization of Screening for Hepatocellular Carcinoma in the United States Jessica A. Davila*, Robert Morgan, Xianglin L. Du, Peter Richardson, Katherine A. McGlynn, Hashem B. El-Serag

ORAL SESSIONS—SCIENTIFIC SESSIONS 4:15 #783

Angiotensin II Type 1 Receptor Antagonist Attenuates Hepatic Carcinogenesis in Nonalcoholic Steatohepatitis in Rats Yosui Tamaki, Yukiomi Nakade*, Ryuji Sudo, Kenji Chisaka, Yohei Kitano, Mitsuyoshi Okada, Kakuya Matsumoto, Kazunobu Aso, Yuichi Makino, Masakazu Haneda

4:30 #784

Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography Predicts VEGF Expression and Malignant Potential in Hepatocellular Carcinoma Koji Kitamura*, Etsuro Hatano, Satoru Seo, Tatsuya Higashi, Hiromitsu Nagata, Iwao Ikai, Shinji Uemoto

4:45 #785

Evaluation of Hepatic Reserve Capacity and Volume Loss After Radiofrequency Ablation in Hepatocellular Carcinoma Patients Using Volumetry Analysis Toshihiko Higashizawa

5:00 #786

Is There a Role for Advanced Cytologic Techniques in the Evaluation of Biliary Strictures When Conventional Cytology Is Indeterminate? Shayan Alam*, Thomas Byrne, David D. Douglas, Elizabeth J. Carey, Hugo E. Vargas, Cuong C. Nguyen, M. Edwyn Harrison, Matthew A. Zarka, Ananya Das

5:15 #787

S-Adenosylmethionine Regulates Apurinic/Apyrimidinic Endonuclease 1 Expression and Contributes to Increased Genomic Instability in Livers of Methionine Adenosyltransferase 1A Deficient Mice Maria Lauda Tomasi*, Ainhoa Iglesias-Ara, Francesco Feo, Shelly C. Lu

AASLD Research Forum 4:00 PM - 5:30 PM

7A San Diego Convention Center

5:15 #793

AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM 10 San Diego Convention Center Chairs: William D. Chey, Nicholas J. Shaheen Sponsored by: Clinical Practice

CLINICAL PRACTICE Participants will be able to: • Discuss the latest information on colorectal cancer screening and surveillance; • Understand risks that may be associated with the use of proton pump inhibitors; and • Identify the impact of war related trauma on the likelihood of developing IBS. 4:00 #794

The Continued Follow Up Study of the Polyp Prevention Trial: A Prospective Study of Utilization and Yield of Surveillance Colonoscopy Adeyinka O. Laiyemo*, Paul Pinsky, Pamela Marcus, Elaine Lanza, Amanda J. Cross, Arthur Schatzkin, Robert E. Schoen

4:15 #795

Interval Cancer After Total Colonoscopy: Results from a Pooled Analysis of Eight Studies Douglas J. Robertson*, David A. Lieberman, Sidney J. Winawer, Dennis Ahnen, E. Robert Greenberg, John A. Baron, John H. Bond, Ruiyun Jiang, Maria Elena Martinez

4:30 #796

Cost-Effectiveness of Surveillance for Ulcerative ColitisAssociated Colorectal Cancer in the Setting of 5-ASA Maintenance Therapy. Joel H. Rubenstein*, Akbar K. Waljee, Fernando S. Velayos, Uri Ladabaum, Peter D. Higgins

4:45 #797

Dyspeptic Symptom Development After Discontinuation of a Proton Pump Inhibitor: Clinical Importance of Acid-Rebound Anna Niklasson*, Lina M. Lindström, Magnus Simren, Greger Lindberg, Einar Bjornsson

5:00 #798

The Long-Term (>=5 Years) Use of Proton Pump Inhibitors Is Associated with An Increased Risk of Osteoporosis-Related Fracture Laura E. Targownik*, Lisa M. Lix, Colleen J. Metge, Heather J. Prior, Stella Leung, William D. Leslie

5:15 #799

Positive Association Between Traumatic War Experiences in the Sandinista Revolution and Subsequent IBS: A Population-Based Study in Nicaragua Daniel Wurzelmann, Rodolfo Pena, Loreto Cortes, Eliette Valladares, Paris . Heidt, Douglas R. Morgan*

Chairs: Gyongyi Szabo, Stephen D. Zucker INFLAMMATION AND IMMUNITY OF LIVER DISEASES 4:00 #788

Development of a New Mouse Model of Fatal Autoimmune Hepatitis Norihiko Watanabe*, Masahiro Kido, Takuji Akamatsu, Junya Tanaka, Kazuyuki Saga, Akiyoshi Nishio, Tsutomu Chiba

4:15 #789

Levels of Fgl2/Fibroleukin An Effector of CD4+Cd25+Treg Cells Predicts Course of Chronic Hepatitis C Disease Nazia Selzner*, Yi Zhu, Itay Shalev, Oyedele Adeyi, Katharina Foerster, Khattar Ramzi, Gary A. Levy

4:30 #790

IFN-γ-Producing γδT Cells Promote Liver Inflammation and Injury in Virus Infected Liver Via a CytokineChemokine Cascade Maureen Ajuebor*, Yijun Jin, Griffin Gremillion, Qingling Chen, Patrick Adegboyega

4:45 #791

Competitive Inhibition of Leptin Signaling By a Mutagenic Peptide Results in Amelioration of Acute Autoimmune Concanavalin a and Pseudomonas Exotoxin a Hepatitis Eran Elinav*, Muhammed Ali, Eli Brazowsky, Zamir Halpern, Arieh Gertler

5:00 #792

Mechanism of Bilirubin Inhibition of iNOS UpRegulation By Lipopolysaccharide Darcey Smith*, Stephen D. Zucker

An Increased Serum Level of High-Mobility Group Box 1 in the Pig Fulminant Hepatic Failure Model Kiminori Takano*, Masahiro Shinoda, Minoru Tanabe, Yasushi Fuchimoto, Taku Miyasho, Shingo Yamada, Koichi Suda, Koichi Fukunaga, Hideaki Obara, Shigeyuki Kawachi, Minoru Okamoto, Hiroshi Yokota, Makio Mukai, Ken Hoshino, Yasuhide Morikawa, Ikuro Maruyama, Akitoshi Ishizaka, Yuko Kitagawa

P-109

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM 4 San Diego Convention Center

4:15 #807

Repetitive Colorectal Distension in Neonatal Rats Induces Colonic Mucosal and Muscular Dysfunction in Adulthood Archana Rao*, Elie D. Al-Chaer, Beverley Greenwood-Van Meerveld

4:30 #808

Direct Medical Costs Associated with Constipation from Childhood to Early Adulthood: A Birth Cohort Study Denesh K. Chitkara*, Nicholas J. Talley, Nilay Shah, Amy Weaver, Slavica Katusic, Miranda A. Van Tilburg, William E. Whitehead, G. Richard Locke

4:45 #809

The Economic Burden of Childhood Constipation in the United States Olivia Liem*, Jeffrey S. Harman, Hayat M. Mousa, Kelly J. Kelleher, Marc A. Benninga, Carlo Di Lorenzo

5:00 #810

Specific Regulation of Nuclear P27Kip1 Expression and Cyclin-Dependent Kinase Inhibitory Activity By Glycogen Synthase Kinase-3β in Intestinal Cell Differentiation Qingding Wang*, Yuning Zhou, Xiao-fu Wang, B. M. Evers

5:15 #811

Aging Gastric Mucosa Exhibits Impaired Angiogenesis, Arrested Vasculogenesis and Delayed Healing. Reduced VEGF, VEGFR2, cAMP, Increased Endostatin and Dysfunction of Bone Marrow-Derived Endothelial Precursors Are the Underlying Mechanisms. Andrzej Tarnawski*, Amrita Ahluwalia, Xiaoming Deng, Wanjun Bae, Zsuzsanna Sandor, Sandor Szabo

Chairs: Vincent W. Yang, John M. Carethers Sponsored by: Gastrointestinal Oncology

GASTROINTESTINAL ONCOLOGY Participants will be able to: • Obtain new information from various studies on aspects of oncology and gastroenterology. 4:00 #800

4:15 #801

Determination of Mutation Frequency and Rate of Activin Receptor 2 (Acvr2) and Transforming Growth Factor Receptor 2 (Tgfbr2) in Colorectal Cells with Different DNA Mismatch Repair (MMR) Defects Heekyung Chung*, Dennis J. Young, Thuy-Anh T. Le, Jeffrey K. Lee, Deena Ream-Robinson, John M. Carethers

4:30 #802

Atonal Homolog 1 Is a Tumor Suppressor in Colorectal Cancers Avedis Kazanjian, Jarred T. Burkart, Noah F. Shroyer*

4:45 #803

Aspirin and Non-Steroidal Anti-Inflammatory Drug Use and the Risk of Colorectal Cancer According to Plasma Inflammatory Markers Andrew T. Chan*, Edward L. Giovannucci, Charles S. Fuchs

5:00 #804

T U E S D A Y MAY 20

TGF-β Pathway Members ELF and SMAD3 Are Key Tumor Suppressors in Human Beckwith-Wiedemann Syndrome Geeta Upadhyay*, Youngwoo Kim, Zhixing Yao, Wilma S. Jogunoori, Rupen Amin, Pete Kreishman, Michael Zasloff, Moin Ahmad, Aziza Shad, Premkumar Reddy, Bibhutibushan Mishra, Rosanna Weksberg, Lopa Mishra

Marked Efficacy of Difluoromethylornithine (DFMO) Plus Sulindac in Reducing Recurrent Colorectal Adenomas in Patients with Prior Adenomas: Results of a Randomized, Placebo-Controlled Double-Blind Trial Daniel Pelot*, Frank L. Meyskens, Eugene Gerner, Christine E. McLaren, Sharon E. Fujikawa-Brooks, Michael J. Lawson, Jayashri Kidao, John McCracken, Ronald Griffin, C G. Albers, Philip Carpenter, Dennis Ahnen, D. K. Turgeon, Curt H. Hagedorn

AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM 30E San Diego Convention Center Chairs: Helen E. Raybould, Catia Sternini Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

HORMONES AND RECEPTORS: GROWTH AND APOPTOSIS Participants will be able to: • Learn about recent advances in cell differentiation, growth and carcinogenesis; and • Understand the role of hormones and receptors in intestinal neoplasia and metastasis. 4:00 #812

Inactivation of Cholecystokinin-2 Receptor Inhibits Progastrin-Dependent Colonic Proliferation and Colorectal Cancer in Mice Guangchun Jin*, Alexander N. Dubeykovskiy, David M. Pritchard, Kelly S. Betz, Andrea Varro, Timothy C. Wang

4:15 #813

Gastrin Is An Essential Cofactor in HelicobacterAssociated Gastric Carcinogenesis and Metastasis in C57bl/6 Mice Shigeo Takaishi*, Shuiping Tu, Tomoyuki Okumura, Wataru Shibata, Sheng-Wen Wang, Zinaida Dubeikovskaya, Ramanathan Vigneshwaran, Shanisha A. Gordon, Arlin B. Rogers, Barry H. Rickman, Sureshkumar Muthupalani, Mark T. Whary, James G. Fox, Timothy C. Wang

GROWTH, DEVELOPMENT & AGING

4:30 #814

Participants will be able to: • Obtain new information from various studies on growth, development and aging.

Octreotide Stimulates Menin in Somatostatin-Expressing Cells of the Duodenum Edith Mensah-Osman*, Juanita L. Merchant

4:45 #815

Physiological Significance of Bone Morphogenetic Protein (BMP) Signaling in the Stomach Masahiko Shinohara, Maria Y. Mao, Theresa M. Keeley, Mohamad El Zaatari, Kathryn A. Eaton, Linda C. Samuelson, Juanita L. Merchant, Andrea Todisco*

5:00 #816

TNF Transactivation of EGFR Modulates TNFStimulated COX-2 Expression Stuart Hobbs*, Jeremy A. Goettel, Dongchun Liang, Robert H. Whitehead, D. Brent Polk

5:15 #805

The Polyp Prevention Trial Continued Follow-Up Study (Ppt-Cfs): Ongoing Colorectal Cancer Risk Despite Surveillance Colonoscopy Keith Leung*, Paul Pinsky, Adeyinka O. Laiyemo, Elaine Lanza, Arthur Schatzkin, Robert E. Schoen

AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM 30A San Diego Convention Center Chairs: Mark Lowe, Eric Sibley Sponsored by: Growth, Development & Aging

4:00 #806

P-110

Lgr5/Gpr49: A Stem Cell Marker in the Native Human Colonic Epithelium Amy Reynolds, Alyson Parris, Natalia Scobioala-laker, Richard Tighe, Michael P. Lewis, Mark R. Williams*

ORAL SESSIONS—SCIENTIFIC SESSIONS 5:15 #817

M3 Muscarinic Receptor Deficiency Reduces Small Intestinal Neoplasia in the APCMin/+ Mouse Model of Colon Cancer Jasleen Shant*, Kunrong Cheng, Guofeng Xie, Jean-Pierre Raufman

AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM 3 San Diego Convention Center Chairs: Marshall H. Montrose, Gary D. Wu

AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM 6B San Diego Convention Center

Sponsored by: Intestinal Disorders

Chairs: William J. Sandborn, R. Balfour Sartor

Participants will be able to: • Obtain new information from various studies on intestinal tight junctions and barrier function.

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IMIBD IMMUNOLOGY, MICROBIOLOGY & INFLAMMATORY BOWEL DISEASE DISTINGUISHED ABSTRACT PLENARY Participants will be able to: • Be familiar with the association between azathioprine and lymphoma in patients with inflammatory bowel disease; • Be familiar with the use of mucosal signature genes to predict response to infliximab; and • Be familiar with the use of erythrocyte mediated delivery of dexamethasone to treat ulcerative colitis. 4:00 #818

Excess Risk of Lymphoproliferative Disorders (LPD) in Inflammatory Bowel Diseases (IBD): Interim Results of the Cesame Cohort Laurent Beaugerie*, Fabrice Carrat, Anne-Marie Bouvier, Nicole Brousse, Franck Carbonnel, Jean-Frédéric Colombel, Jean Faivre, Jean-Francois Flejou, Olivier Hermine, Marc Maynadie, Jean-Louis Dupas, Jean-Pierre Gendre, Philippe Godeberge, Jean-Pierre Hugot, Marc Lemann, Stephane Nahon, Jean-Marc Sabate, Gilbert Tucat, For the CEAME Study group

4:15 #819

Reconstitution of Physiological Immune Responses to Bacterial DNA During Experimental Colitis Can Be Achieved By Inhibition of Gsk3-β Claudia Hofmann*, Nadja Dunger, Nicole Grunwald, Juergen Schoelmerich, Werner Falk, Florian Obermeier

4:30 #820

Erythrocytes-Mediated Delivery of Low Doses of Dexamethasone Revert Steroid-Dependency in Ulcerative Colitis. a Double-Blind, Sham-Controlled Study Fabrizio Bossa*, Anna Latiano, Luigia Rossi, Mauro Magnani, Orazio Palmieri, Bruno Dallapiccola, Sonja Serafini, Gianluca Damonte, Angelo Andriulli, Vito Annese

4:45 #821

5:00 #822

5:15 Sp732

Muc1 Limits H. pylori Infection By Acting As a Releasable Decoy Sara K. Linden*, Kim M. Miles, Timothy H. Florin, Andre Dubois, Michael A. McGuckin Mucosal Gene Signatures to Predict Response to Infliximab in Patients with Inflammatory Bowel Disease Ingrid Arijs*, Leentje Van Lommel, Kristel Van Steen, Gert De Hertogh, Marc Ferrante, Marie Joossens, Karel Geboes, Gert A. Van Assche, Severine Vermeire, Frans C. Schuit, Paul J. Rutgeerts Highlights of Basic and Translational Research in IBD from DDW 2008 Maria T. Abreu

INTESTINAL TIGHT JUNCTIONS AND BARRIER FUNCTION

4:00 #823

TNF-Induced Cell Shedding in the Small Intestine Causes Novel Reorganization of Tight Junctional Proteins Amanda M. Marchiando, Yanfang Guan, Aaron L. Hecht, Elizabeth M. Angus, Marshall H. Montrose, Jerrold R. Turner, Alastair J. Watson*

4:15 #824

Acetaldehyde Disrupts Tight Junctions (TJS) in CACO-2 Cell Monolayers By Pp2a Translocation and Dephosphorylation of Occludin On Threonine Residues M. Dunagan*, Radhakrishna (RK) Rao, Ankur Seth

4:30 #825

Reciprocal Effects of Tumor Necrosis Factor Alpha and Prohibitin in Intestinal Epithelial Cells Arianne L. Theiss*, Ngozi I. Okoro, Didier Merlin, Shanthi V. Sitaraman

4:45 #826

T403/404d Mutation of Occludin Attenuates PKCηMediated Regulation of Epithelial Tight Junctions (TJS) Bertha Elias, Sudhir Aggarwal, Le Shen, Jerrold R. Turner, Radhakrishna (RK) Rao*

5:00 #827

Actomyosin-Dependent ZO-1 Stabilization At the Tight Junction Regulates Barrier Function. Dan Yu*, Jerrold R. Turner

5:15 #828

Glucocorticoids Stimulate Tight Junction Sealing in Intestinal Epithelial Cells By Modulating Expression of Claudin-2 and Claudin-4 Andreas Fischer*, Markus Gluth, Ulrich-Frank Pape, Bertram Wiedenmann, Daniel C. Baumgart, Franz Theuring

AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM 26B San Diego Convention Center Chairs: James H. Grendell, Markus M. Lerch Sponsored by: Pancreatic Disorders

PANCREATIC DISORDERS Participants will be able to: • Describe new developments in the prediction of severity in acute pancreatitis; and • Recognize new tools and procedures in the management of complications of severe acute pancreatitis. 4:00 #829

Gastrointestinal Permeability and Infectious Complications in Acute Pancreatitis; a Prospective Multicenter Study Marc G. Besselink*, Hjalmar C. van Santvoort, Marja A. Boermeester, Kathelijn Fischer, Willem Renooij, Martin B. de Smet, Geert A. Cirkel, Bert van Ramshorst, Bas L. Weusten, Alexander F. Schaapherder, Ben J. Witteman, Rutger J. Ploeg, Harry van Goor, Cees J. van Laarhoven, Camiel Rosman, Menno A. Brink, Erwin van der Harst, Peter J. Wahab, Casper H. van Eijck, Cornelis H. Dejong, Karel J. van Erpecum, Louis M. Akkermans, Hein G. Gooszen, Members Dutch Acute Pancreatitis Study Group

P-111

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS 4:15 #830

Correction of Azotemia Is Associated with Reduced Mortality in Acute Pancreatitis Bechien U. Wu*, Richard S. Johannes, Xiaowu Sun, Darwin Conwell, Peter A. Banks

4:30 #831

Prognostic Factors and Outcome of 121 Patients with Non-Surgical Therapy of Necrotizing Pancreatitis: What Is the Impact of An Infection of the Necrosis? Wolfgang Huber*, Marion Neudeck, Katja Hauptvogel, Andreas Umgelter, Wolfgang Reindl, Andreas Weber, Jens T. Siveke, Christoph Lampart, Roland M. Schmid

4:45 #832

Prospective Randomized Trial Comparing Early Versus Delayed Oral Refeeding in Moderate Acute Pancreatitis Pierre H. Deprez*, Andre P. Geubel, Etienne Danse, Yves Horsmans

5:00 #833

A Comparitive Study of Primary Conservative Treatment Versus Surgery for Infected Pancreatic Necrosis Over Ten Years (1997-2006) Manik Sharma*, Pramod K. Garg, Debabrata Banerjee, Kaushal Madan, Peush Sahni, Girish K. Pande

5:15 #834

A Comparison of Direct Endoscopic Necrosectomy and Usual Transmural Endoscopic Techniques for the Treatment of Walled Off Pancreatic Necrosis Timothy B. Gardner*, Prabhleen Chahal, Santhi Swaroop Vege, Bret T. Petersen, Christopher J. Gostout, Mark D. Topazian, Naoki Takahashi, Todd H. Baron

AGA Institute Research Forum 4:00 PM - 5:30 PM

5:15 #840

AGA Institute Research Forum 4:00 PM - 5:30 PM

Sponsored by: Intestinal Disorders

CLINICAL INTESTINAL DISORDERS Participants will be able to: • Familiarize themselves with recent clinical intestinal disorders research findings and implications. 4:00 #841

The Natural History of Microscopic Colitis Treated with Corticosteroids Adil A. Abdalla*, Yuning Xiong, Edward V. Loftus, Thomas C. Smyrk, Stephen Cha, Patricia P. Kammer, William J. Sandborn, Darrell S. Pardi

4:15 #842

Genetic Risk Factors for Post-Infectious IBS in the Walkerton Outbreak of Waterborne Gastroenteritis Alexandra-Chloe Villani*, Mathieu Lemire, Marroon Thabane, Geneviève Geneau, Alexandre Bélisle, Genevieve Fortin, Stephen M. Collins, Denis Franchimont, John K. Marshall

4:30 #843

A Prospective Study of the Prevalence of Gastrointestinal Symptoms in Patients with Type 1 Diabetes Mellitus and Correlation with Diabetes Control and Quality of Life John S. Leeds*, Andrew D. Hopper, Solomon Tesfaye, David S. Sanders

4:45 #844

Lubiprostone Reverses the Inhibitory Action of Morphine On Mucosal Secretion in the Human Jejunum Xiaohong Sun*, Yun Xia, Sumei Liu, Yu-Zhong Wang, MeiHua Qu, Xiyu Wang, Guo-Du Wang, Bradley Needleman, Dean J. Mikami, William Scott Melvin, Laura M. Bohn, Ryuji Ueno, Jackie D. Wood

5:00 #845

Severe Downregulation of the NHE3 Adapterprotein Pdzk1 (NHERF3) in Colonic Mucosa of Patients with Active IBD - Implications for the Dysregulation of Salt and Water Transport Katja Rode, Brigitte Riederer, Oliver Bachmann, Henrike Lenzen, Jochen Wedemeyer, Michael P. Manns, Ursula E. Seidler*

5:15 #846

How Often Do Patients Rebleed During Long-Term Follow-Up After An Initial Documented Diverticular Hemorrhage? Dennis M. Jensen*, Bhavneet Singh, Mary Ellen Jensen, Nan Sun, Martha Carrico

Sponsored by: Neurogastroenterology and Motility

BRAIN GUT INTERACTIONS AND NEUROIMAGING Participants will be able to: • Learn more about research developments in brain gut interactions; • Learn more about the role of brain gut interactions in irritable bowel syndrome; and • Learn about neuroimaging of the human brain.

T U E S D A Y MAY 20

4:00 #835

Assessment of Functional Brain Activation in Expectation of Visceral Pain in a Rat Step-Down Passive Avoidance Model Zhuo Wang*, Sylvie Bradesi, Jonathan R. Charles, Raina Pang, Jean Michel I. Maarek, Kevin Lee, Wendy J. Winchester, Emeran A. Mayer, Daniel P. Holschneider

4:15 #836

The Effects of Acute Esophageal Acid Exposure On the Expression Profile of Neurotransmitter Receptor Genes in the Rat Cingulate Cortex Banani Banerjee*, Ivan M. Lang, Bidyut K. Medda, Robert Birkett, Reza Shaker

4:30 #837

5-Httlpr Gene Polymorphism Modulates Activity and Connectivity Within An Emotional Arousal Network of Healthy Control Subjects During Visceral Pain Jennifer S. Labus*, Emeran A. Mayer, Toyohiro Hamaguchi, Tomoko Mizuno, Michiko Kano, Shin Fukudo

4:45 #838

Contralesional High Frequency Cortical Stimulation Can Reverse a Virtual Lesion in Dominant Swallowing Motor Cortex in Intact Man Shaheen Hamdy*, Samantha Jefferson, Satish Mistry, Louise Hancock, John C. Rothwell

5:00 #839

Chronic Stress Induces Long-Term Smooth Muscle Hypersensitivity By Enhancing the Gene Expression of CAV1.2 (L-Type) Calcium Channels in Colonic Circular Smooth Muscle Cells Barun K. Choudhury*, Xuan-Zheng P. Shi, Sushil K. Sarna

P-112

32AB San Diego Convention Center

Chairs: Mark T. Worthington, Keith T. Wilson

30D San Diego Convention Center

Chairs: Jennifer S. Labus, Qasim Aziz

Anatomical Connexions Between Brain Areas Activated During Rectal Distension in Healthy Women: A Visceral Pain Network Jean Marc Sabate*, Xavier Moisset, Didier Bouhassira, Denis Ducreux, Dominique Glutron, Benoit Coffin

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 4:00 PM - 5:30 PM

33BC San Diego Convention Center

4:45 #856

Phosphodiesterase Isozymes Involved in Regulatory Mechanism of Acid Secretion in Isolated Mouse Stomachs Yasuyuki Ito*, Eitaro Aihara, Sayaka Okuda, Shinichi Kato, Koji Takeuchi

5:00 #857

Differential Regulation of H,K-ATPase Gene Expression By Helicobacter pylori and IL-1β Arindam Saha*, Charles E. Hammond, Maria Trojanowska, Adam J. Smolka

5:15 #858

Helicobacter pylori-Negative Chronic Active Gastritis: A New Entity or the Result of Widespread Acid Inhibition? Robert M. Genta*, Christopher M. Schuler, Richard H. Lash

Chairs: William L. Hasler, Tamas Ordog Sponsored by: Neurogastroenterology and Motility

GASTROPARESIS: PATHOGENESIS AND TREATMENT Participants will be able to: • Understand current concepts and treatment options for gastroparesis. 4:00 #847

Effect of Multi-Point Gastric Electrical Pacing (MGP) On Symptoms, Gastric Emptying and Electrical Activity in Diabetic Gastroparesis Irene Sarosiek*, Jameson Forster, Katherine Roeser, Richard McCallum

AGA Institute Research Forum 4:00 PM - 5:30 PM

2 San Diego Convention Center

4:15 #848

Effects of Electrical Stimulation of Various Segment Along the Gut On Slow Waves in Dogs Yan Sun*, Geng-Qing Song, Jiande Chen

4:30 #849

Enteric Neuropathology in Gastroparesis Justin Harberson*, Rebecca Thomas, Sean P. Harbison, Henry P. Parkman

Sponsored by: Esophageal, Gastric & Duodenal Disorders

4:45 #850

Induction of Heme Oxygenase Reverses Diabetic Gastroparesis in NOD/Ltj Mice Kyoung Moo Choi*, Simon J. Gibbons, Tien Nguyen, Gary Stoltz, Matthew S. Lurken, Joseph H. Szurszewski, Gianrico Farrugia

Participants will be able to: • Review recent research in the area of GERD: pharmacological treatment.

5:00 #851

Differential Distribution of Prostaglandin EP2 and EP3 Receptor in the Gastric Corpus and Antrum Is Responsible for Tachygastria Evoked By Hyperglycemia Shi-Yi Zhou*, Il Song, Yuanxu Lu, Chung Owyang

5:15 #852

Impaired Gastric Motility and 13C Breath Test Gastric Emptying in Rats with Experimental Spinal Cord Injury Gregory M. Holmes*, Melissa Tong, Emily Q. Creekmore

AGA Institute Research Forum 4:00 PM - 5:30 PM

Chairs: Joel E. Richter, Roy K. Wong

UPDATE IN PHARMACOLOGICAL TREATMENT OF GERD

4:00 #859

Initial Control of Acid Reflux After Laparoscopic AntiReflux Surgery (Lars) Compared to Chronic Use of Esomeprazole (ESO) 20-40mg Daily Jan G. Hatlebakk*, Lars R. Lundell, Jean Paul Galmiche, Stephen E. Attwood, Christian Ell, Roberto Fiocca, Tore Lind, Ola Junghard

4:15 #860

On-Demand Versus Daily Proton Pump Inhibitor (PPI) for Maintenance Treatment of Gastroesophageal Reflux Disease (GERD): A Double Blind, Double Dummy, Randomized Placebo Controlled Trial and CostEffectiveness Analysis Justin Wu*, Yawen Chan, Kelvin K. Tsoi, Vincent W. Wong, Larry Lai, Grace Wong, Dorothy K. Chow, Philip W. Chiu, Ka Fai Danny Siu, Joseph J. Sung, Francis K. L. Chan

4:30 #861

Effect of the GABAB Receptor Agonist Azd9343 On Transient Lower Esophageal Sphincter Relaxations and Acid Reflux in Healthy Volunteers: A Phase I Trial Guy E. Boeckxstaens, Hanneke Beaumont*, Hans Rydholm, Magnus Ruth, Aaltje Lei, Anders Lehmann, André Smout

4:45 #862

Is the Response of GERD Patients to PPI Therapy Affected By the Presence of IBS-Like Symptoms? Hubert Monnikes*, Hubert Doerfler, Holger Schmitt, Peter Berghoefer, Robert Heading

5:00 #863

Changes in Esophageal Histology Following Esomeprazole or Laparoscopic Anti-Reflux Surgery for the Management of Chronic Gastroesophageal Reflux Disease: The Lotus Trial Experience Roberto Fiocca*, Stephen E. Attwood, Christian Ell, Jean Paul Galmiche, Jan G. Hatlebakk, Lars R. Lundell, Luca Mastracci, Tore Lind, Ola Junghard

5:15 #864

Effect of Proton Pump Inhibitor On the Gastric Volume: Assessed By Magnetic Resonance Imaging Arash Babaei*, Valmik Bhargava, Sohrab Aalam, Miriam Scadeng, Ravinder K. Mittal

31A San Diego Convention Center

Chairs: Jonathan D. Kaunitz, Tetsuo Arakawa Sponsored by: Esophageal, Gastric & Duodenal Disorders

THE DELICATE INTERPLAY OF ACID AND INFLAMMATION IN THE STOMACH Participants will be able to: • Understand mechanisms through which inflammation influences acid secretion. 4:00 #853

Involvement of Prostacyclin/IP Receptors in Decreased Acid Secretion of Damaged Stomach: Mediation By Somatostatin/SST2 Receptors Shun Terashima*, Hikaru Nishio, Michitaka Ogura, Maya Honda, Koji Takeuchi

4:15 #854

The Role of Proton Pump Inhibition in Eradication of Helicobacter pylori Elizabeth A. Marcus, George Sachs, Yi Wen, Jing Feng, David R. Scott*

4:30 #855

Sulforaphane Ameliorates H. pylori-Induced Gastritis Via Upregulating NRF2-Dependent Peroxiredoxin I in Mice Akinori Yanaka*, Daisuke Sato, Takeshi Shibahara, Ken Itoh, Masayuki Yamamoto, Toru Yanagawa, Tetsuro Ishii, Ichinosuke Hyodo

P-113

T U E S D A Y MAY 20

ORAL SESSIONS—SCIENTIFIC SESSIONS ASGE Topic Forum 4:00 PM - 5:30 PM

1 San Diego Convention Center

4:12 #872

Randomized Comparative Trial of Endoscopic Versus Thoracoscopic Full Thickness Esophageal Wall Repair After Endoscopic Mediastinoscopy in Healthy Versus Compromised Animals in a Long-Term Survival Study Annette Fritscher-Ravens*, Claus F. Eisenberger, Markus P. Ghadimi, Anja Nilges, Patrick Meybohm, Stefan Schiffmann, Peter Milla, Peter Koehler, Bjoern Jacobsen, Frauke Seehusen, Heiner Niemann, Wolfram Trudo Knoefel

4:24 #873

Wireless Endosurgery for NOTES Paul Swain*, Shou Jiang Tang, Richard Bergs, Per-Ola Park, Alexander C. Mosse, Keiichi Ikeda, Maria Bergström, Michael L. Kochman, Raul Fernandez, Jeffrey A. Cadeddu, Daniel J. Scott

4:36 #874

A Randomized Comparison of Hemostasis Using New Flexible Endoscopic Bipolar Forceps (BELA) Versus Laparoscopic Bipolar Forceps in a Porcine Model Per-Ola Park*, Maria Bergström, Christie Cunningham, Gary L. Long, Omar J. Vakharia, Gregory J. Bakos, Kurt R. Bally, Paul Swain, Richard I. Rothstein

Chairs: David R. Lichtenstein, Todd H. Baron ADVANCES IN BILIARY IMAGING 4:00 #865

Peroral Cholangioscopy Guided Stone Therapy - Report of An International Multicenter Registry Mansour A. Parsi*, Horst Neuhaus, Douglas Pleskow, Kenneth F. Binmoeller, Robert H. Hawes, Bret T. Petersen, Stuart Sherman, Peter D. Stevens, Jacques M. Deviere, Oleh Haluszka, Guido Costamagna, Søren Meisner, Thierry Ponchon, Adam Slivka, Yang K. Chen

4:12 #866

Are There Roles for Intraductal Ultrasound and Saline Irrigation in Ensuring Complete Clearance of Common Bile Duct Stones? Tiing Leong Ang*, Eng Kiong Teo, Kwong Ming Fock

4:24 #867

ERCP with Cholangiopancreatoscopy (CP) Is Associated with Higher Rates of Endoscopic Complications Than ERCP Alone Amrita Sethi*, Yang K. Chen, Gregory L. Austin, Brian C. Brauer, Norio Fukami, Abdul H. Khan, Raj J. Shah

4:48 #875

Transgastric Peritoneoscopy Versus Laparoscopy for the Detection and Biopsy of Peritoneal Metastases Douglas O. Faigel*, Rogier P. Voermans, Mark I. van Berge Henegouwen, Sean Conlon, James T. Spivey, Renee L. Rowe, Brett C. Sheppard, Paul Fockens

4:36 #868

Peroral Cholangioscopy (PO) Using a Disposable Steerable Single Operator Catheter for Biliary Stone Therapy and Assessment of Indeterminate Strictures - A Multi-Center Experience Using SPYGLASS Yang K. Chen*, Mansour A. Parsi, Kenneth F. Binmoeller, Robert H. Hawes, Douglas Pleskow, Adam Slivka, Oleh Haluszka, Bret T. Petersen, Stuart Sherman, Jacques M. Deviere, Soren Meisner, Peter D. Stevens, Guido Costamagna, Thierry Ponchon, Horst Neuhaus

5:00 #876

Randomized Multicenter Controlled Study of Endoscopic and Surgical Closure of a Gastric NOTES Access Perforation in a Porcine Model Maria Bergström*, Gottumukkala S. Raju, Paul Swain, Richard I. Rothstein, Per-Ola Park

5:12 Sp734

State-of-the-Art Lecture: NOTES 2008: Reality or Fantasy? Christopher J. Gostout

4:48 #869

5:00 #870

T U E S D A Y MAY 20

5:12 Sp733

Intraductal Balloon Guided Direct Peroral Cholangioscopy Using An Ultra-Slim Upper Endoscope Jong Ho Moon*, Bong Min Ko, Hyun Jong Choi, Su Jin Hong, Hyun Cheol Koo, Young Koog Cheon, Young Deok Cho, Joon Seong Lee, Moon Sung Lee, Chan Sup Shim Biopsy of Indeterminate Biliary Strictures - Does Direct Visualization Help? - A Multicener Experience Douglas Pleskow*, Mansour A. Parsi, Yang K. Chen, Horst Neuhaus, Adam Slivka, Oleh Haluszka, Bret T. Petersen, Jacques M. Deviere, Stuart Sherman, Søren Meisner, Robert H. Hawes, Peter D. Stevens, Thierry Ponchon, Guido Costamagna, Kenneth F. Binmoeller State-of-the-Art Lecture: Visualization of the Biliopancreatic Ducts: Is Seeing Believing? Yang K. Chen

ASGE Topic Forum 4:00 PM - 5:30 PM

5 San Diego Convention Center

SSAT Business Meeting 5:00 PM - 6:00 PM

SSAT ANNUAL BUSINESS MEETING AGA Institute Business Meeting 5:30 PM - 6:30 PM

Sponsored by: Gastrointestinal Oncology

GASTROINTESTINAL ONCOLOGY SECTION BUSINESS MEETING AGA Institute Business Meeting 5:30 PM - 6:30 PM

30A San Diego Convention Center

Chairs: Mark Lowe, Eric Sibley

NOTES

P-114

4 San Diego Convention Center

Chairs: Vincent W. Yang, John M. Carethers

Chairs: Richard I. Rothstein, Lee L. Swanstrom

4:00 #871

25 San Diego Convention Center

Successful Diagnostic and Therapeutic Intrauterine Fetal Interventions By NOTES Samuel A. Giday*, Jonathan M. Buscaglia, Janyne Althaus, Xavier Dray, Eun Ji Shin, Dawn Ruben, Ronald J. Wroblewski, Sergey V. Kantsevoy, Anthony N. Kalloo

Sponsored by: Growth, Development & Aging

GROWTH, DEVELOPMENT & AGING SECTION BUSINESS MEETING

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Business Meeting 5:30 PM - 6:30 PM

30E San Diego Convention Center

Chairs: Helen E. Raybould, Catia Sternini Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

HORMONES, TRANSMITTERS, GROWTH FACTORS & THEIR RECEPTORS SECTION BUSINESS MEETING AGA Institute Business Meeting 5:30 PM - 6:30 PM

6B San Diego Convention Center

Chairs: William J. Sandborn, R. Balfour Sartor Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IMMUNOLOGY, MICROBIOLOGY & INFLAMMATORY BOWEL DISEASE BUSINESS MEETING AGA Institute Business Meeting 5:30 PM - 6:30 PM

3 San Diego Convention Center

Chairs: Marshall H. Montrose, Gary D. Wu Sponsored by: Intestinal Disorders

INTESTINAL DISORDERS SECTION BUSINESS MEETING AGA Institute Business Meeting 5:30 PM - 6:30 PM

8 San Diego Convention Center

Chairs: Richard M. Green, Frank A. Anania Sponsored by: Liver & Biliary

LIVER & BILIARY SECTION BUSINESS MEETING AGA Institute Business Meeting 5:30 PM - 6:30 PM

T U E S D A Y

26B San Diego Convention Center

Chairs: Randall K. Pearson, Rodger A. Liddle Sponsored by: Pancreatic Disorders

PANCREATIC DISORDERS SECTION BUSINESS MEETING

MAY 20

P-115

W E D N E S D A Y MAY 21

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION POSTGRADUATE COURSE/SPECIAL SESSION AASLD Hepatology SEP Session 8:30 AM - 3:00 PM

7B San Diego Convention Center

Chairs: Steven K. Herrine, Jaquelyn F. Fleckenstein ABIM MAINTENANCE OF CERTIFICATION - HEPATOLOGY Participants will be able to: • Increase familiarity with diagnosis and management of non-alcoholic fatty liver disease, viral hepatitis and autoimmune liver diseases; • Review the management of patients with cirrhosis, de-compensated cirrhosis, liver tumors and liver transplantation; and • Discuss current approaches to management patients with pregnancyrelated liver disease, drug-induced hepatotoxicity and metabolic liver disease. 8:30

Welcome and Orientation Session I: Viral Hepatitis and Non-Alcoholic Fatty Liver Disease Steven K. Herrine

10:00

Break

10:15 Sp736

Session II: Complications of Cirrhosis, Liver Disease in Pregnancy Jaquelyn F. Fleckenstein

11:30

Lunch (Boxed Lunch)

12:15 Sp737

1:45 Sp735

2:50 Sp742

UGI Endoprosthetics Peter D. Siersema

3:05 Sp743

Biliary Endoprosthetics Adam Slivka

3:20 Sp744

Colonic Endoprosthetics Steven A. Edmundowicz

3:35

Questions/Audience Response

3:50

Break

NEOPLASIA 4:10

Audience Response

4:30 Sp747

Surveillance Endoscopy in Barrett's Esophagus: Should We Do It and How? Gary W. Falk

Session III: Liver Transplantation, Hepatocellular Carcinoma, Hepatotoxicity and Liver Masses Victor J. Navarro

4:45 Sp748

Pancreatic Neoplasia: The Argument for Screening and Surveillance Marcia I. Canto

Break

5:00 Sp749

Colorectal Cancer Screening and Surveillance: How, Who and How Often? David A. Lieberman

Session IV: Autoimmune Liver Disease, Metabolic Liver Disease Atif Zaman

20BCD San Diego Convention Center

Course Introduction Michelle A. Anderson, Michael L. Kochman, Uri Ladabaum

LUMINAL PATENCY Audience Response

5:15

Questions/Audience Response

Chair: Michelle A. Anderson

Participants will be able to: • Identify current and emerging technologies in endoscopy and apply this knowledge to achieve desired results and minimize complications; characterize current controversies in screening for GI neoplasia, and help patients make informed decisions about screening and surveillance; • Define key issues related to upper gastrointestinal, biliary and colonic endoprosthetics, and utilize these devices more effectively in clinical practice; describe how respected experts combine established data with experience in the approach to common clinical problems, and integrate these strategies into their own practice as applicable; and • Differentiate models of sedation for endoscopy, and apply the models appropriate to individual practice settings; and discuss current trends in quality assurance, training and legal issues affecting endoscopic practice.

P-116

Esophageal Stricture Management Janak N. Shah

Screening for High-Risk Pre-Malignant Lesions Jason A. Dominitz

ENDOSCOPIC PRACTICE 2008: AT THE INTERFACE OF EVIDENCE AND EXPERT OPINION

2:10

2:35 Sp741

4:15 Sp746

ASGE Postgraduate Course 2:00 PM - 6:00 PM

2:00 Sp739

The Basil I. Hirschowitz, MD Lecture: The Future of Endoprosthetic Technology David L. Carr-Locke

Chair: Douglas K. Rex

8:45 Sp738

1:30

2:15 Sp740

EXPERTS IN THE HOT SEAT 5:30 Sp745

Case Topic: Cystic Lesions of the Pancreas Gregory G. Ginsberg, Douglas O. Faigel

ORAL SESSIONS—SCIENTIFIC SESSIONS SCIENTIFIC SESSIONS ASGE Breakfast with Champions 6:30 AM - 8:00 AM

Sp751

ASGE Plenary Session 8:15 AM - 12:00 PM

Ablation of Barrett's Esophagus (BC09) Kenneth K. Wang Coronado (South Tower)

Marriott Hotel & Marina Sp750

Colonoscopy: Optimizing Performance (BC10) Douglas K. Rex Rancho Las Palmas (South Tower)

Marriott Hotel & Marina Sp752

ERCP: Optimizing Cannulation Success (BC11) David L. Carr-Locke Torrance (South Tower)

Marriott Hotel & Marina Sp753

Chairs: Grace H. Elta, John L. Petrini, M. Brian Fennerty

8:15

Welcome

8:20 #877

Cost Savings of Removing Diminutive Polyps Without Histologic Assessment William R. Kessler*, Robert W. Klein, Ronald C. Wielage, Douglas K. Rex

8:35 #878

American College of Radiology (ACR) Recommendations for CT Colonography (CTC) Interpretation: Implications for Resection of High Risk Adenoma Findings Douglas K. Rex*, Andrew Overhiser, Shawn Chen

8:50 #879

Water Immersion Vs Conventional Colonoscopy Insertion: A Randomized Controlled Trial Showing Promise for Minimal-Sedation Colonoscopy Cynthia W. Leung*, Tonya R. Kaltenbach, Kuan K. Wu, Roy M. Soetikno, Shai Friedland

9:05 Sp762

J. Edward Berk, MD, DSc, FASGE State-of-the-Art Endowed Lecture: New Colonoscopy Techniques Douglas K. Rex

9:25 Sp763

Presidential Address: Endoscopy: Past, Present, and Future Grace H. Elta

9:45 Sp764

Inauguration of 2008-2009 President John L. Petrini

9:50 #880

Clip Closure Versus Endoscopic Suturing Versus Thoracoscopic Repair of An Esophageal Perforation: Randomized Comparative Long Term Survival Study in a Porcine Model Annette Fritscher-Ravens*, Peter Milla, Stefan Schiffmann, Axel von Herbay, Claus F. Eisenberger, Amir Ghanbari, Anja Nilges, Markus P. Ghadimi, Peter Koehler, Wolfram Trudo Knoefel

10:05 #881

A Prospective Randomized Controlled Trial of NOTES Versus Laparoscopic Distal Pancreatectomy, Preliminary Results Field F. Willingham*, Denise W. Gee, Patricia Sylla, Avinash Kambadakone R, Anandkumar Singh, Dushyant V. Sahani, Mari Mino-Kenudson, David W. Rattner, William R. Brugge

10:20 Sp765

Jack A. Vennes, MD and Stephen E. Silvis, MD State-ofthe-Art Endowed Lecture: NOTES: Where We Are Going and Where Are We Going? Richard I. Rothstein

10:40

The Rudolf V. Schindler Award, Presented by 2008-09 ASGE President, John L. Petrini, MD, FASGE

10:55 #882

Hemostasis of Very High Risk Patients with Severe NonVariceal UGI Hemorrhage Comparing InjectionHemoclipping with Injection-MPEC Dennis M. Jensen*, Thomas O. Kovacs, Gordon V. Ohning, Rome Jutabha, Gustavo A. Machicado, Gareth S. Dulai

AGA Institute Sunrise Discussion 7:00 AM - 8:00 AM 32AB San Diego Convention Center Chairs: Carol E. Semrad, Robert P. Anderson Sponsored by: Intestinal Disorders

ADVANCES IN CELIAC DISEASE Participants will be able to: • Review the advances in celiac disease presented at DDW 2008. 7:00 Sp754

Advances in Celiac Disease Carol E. Semrad, Robert P. Anderson

7:44 Sp756

Natural History of Celiac Disease, Can We Stop Gluten Free Diet? Tamara Matysiak-Budnik

SSAT Conference/Debate/Panel/Symposium 7:00 AM - 8:30 AM 25 San Diego Convention Center Chairs: Mark P. Callery, Fabrizio Michelassi Sponsored by: ISDS

SSAT/ISDS JOINT SYMPOSIUM: HOW I DO IT: AROUND THE WORLD IN 90 MINUTES 7:00 Sp757

Laparoscopic Proctocolectomy with J-Pouch Ileo-Anal Anastomosis Tonia M. Young-Fadok

7:12 Sp758

Advanced Liver Resections Chung-Mau Lo

7:24 Sp759

Laparoscopic Sleeve Gastrectomy Herbert Freund

7:36 Sp760

Debridment for Infected Pancreatic Necrosis Claudio Bassi

7:48 Sp761

Laparoscopic Paraesophageal Hernia Repair: Facts and Myths Marco G. Patti

8:00

MAY 21

ENDOSCOPIC RESEARCH LEADS THE WAY

Luminal Stents: What Is the Best Approach? (BC12) Mission Hills Todd H. Baron

Marriott Hotel & Marina

20BCD San Diego Convention Center

W E D N E S D A Y

Audience Discussion

P-117

W E D N E S D A Y MAY 21

ORAL SESSIONS—SCIENTIFIC SESSIONS 11:10 #883

11:25 #883a

Non-Anesthesiologist Administered Propofol Sedation for Endoscopic Procedures: A Worldwide Safety Review Viju P. Deenadayalu*, Emely F. Eid, John S. Goff, John A. Walker, Lawrence B. Cohen, Ludwig T. Heuss, Shajan Peter, Christoph Beglinger, James Sinnott, Patrick D. Gerstenberger, Anthony C. Clarke, Harold Munnings, Magdy Z. Rofail, Iyad M. Subei, Rodger A. Sleven, Akira Horiuchi, Kuldip Sandhu, Paul A. Jordan, Douglas K. Rex Carbon Dioxide (CO2) Insufflation During ERCP for the Reduction of Post-Procedure Pain: Preliminary Results of a Randomized, Double-Blind Controlled Trial Rajesh N. Keswani, Robert M. Hovis, Steven A. Edmundowicz, Esmat Z. Sadeddin, Sreenivasa S. Jonnalagadda, Riad R. Azar, Lawrence Waldbaum, John T. Maple*

11:40 Sp766

State-of-the-Art Lecture: Are Our Patients Sleeping Safer and Sounder? John J. Vargo

12:00

Close of Session

AGA Institute Clinical Symposium 8:30 AM - 10:00 AM 29 San Diego Convention Center

9:16 Sp772

Role of the Gastroenterologist: To Treat or Not? Stuart J. Spechler

9:38 Sp772a

Is It GERD or EoE: The Pathologist's Perspective Robert D. Odze

AGA Institute Clinical Symposium 8:30 AM - 10:00 AM 20A San Diego Convention Center Chairs: Robin C. Spiller, Christian D. Stone Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease; Esophageal, Gastric & Duodenal Disorders; Clinical Practice; Neurogastroenterology and Motility

FUNCTIONAL SYMPTOMS AND STRESS IN PATIENTS WITH IBD Participants will be able to: • Identify the overlap between IBD and IBS; • Describe the impact of stress on IBD; and • Become familiar with the risks associated with therapy for IBD. 8:30 Sp774

Do Patients with IBD Have IBS and Is IBS a Form of IBD? David S. Rampton

9:00 Sp775

How Does Stress Affect IBD? Lesley A. Graff

9:30 Sp776

Risks in Crohn's Disease: What Is the Risk of the Disease and What Is the Risk of the Drugs? Corey A. Siegel

Chairs: Mohammad A. Wehbi, Robert E. Schoen Sponsored by: Gastrointestinal Oncology; Clinical Practice; Imaging & Advanced Technology ; Growth, Development & Aging

COLORECTAL CANCER SCREENING: CLINICAL CONSIDERATIONS Participants will be able to: • Recall issues related to quality and standardization of screening colonoscopy; • Describe the significance of small polyps detected during CT colonography; and • Summarize the most recent update on the guidelines of screening colonoscopy. 8:30 Sp767

Standardized Colonoscopy Reporting and Data System David A. Lieberman

9:00 Sp768

Management of Small Polyps Detected By CT Colonography Chin Hur

9:30 Sp769

Update On Colorectal Cancer Screening Guidelines Robert A. Smith

AGA Institute Clinical Symposium 8:30 AM - 10:00 AM 5 San Diego Convention Center Chairs: Donald O. Castell, Joel H. Rubenstein Sponsored by: Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Neurogastroenterology and Motility

THE CHANGING FACE OF GERD Participants will be able to: • Be familiar with the prevalence and approach to a patient with NERD; • List the various diagnostic options including endoscopy, histology, pH monitoring, and impedance in GERD patients; and • Recognize the controversy in the treatment of non acid reflux.

AGA Institute Clinical Symposium 8:30 AM - 10:00 AM 6F San Diego Convention Center

8:30 Sp777

Diagnostic and Therapeutic Approach to NERD Nicholas J. Shaheen

Chairs: Sandeep K. Gupta, Stuart J. Spechler

8:53 Sp778

Role of Endoscopy in Patients with GERD Symptoms Richard E. Sampliner

Sponsored by: Esophageal, Gastric & Duodenal Disorders; Clinical Practice; Nutrition & Obesity ; Growth, Development & Aging

9:16 Sp779

Esophageal Biopsies in GERD Patients: Yes or No Roy C. Orlando

EOSINOPHILIC ESOPHAGITIS: PERSPECTIVES IN 2008

9:38 Sp780

Diagnostic Utility of Impedance and Non Acid Reflux Kenneth R. DeVault

Participants will be able to: • Recognize differences in EoE and GERD; • Describe the pathophysiology of EoE; and • Learn how to evaluate and treat EoE. 8:30 Sp770

Epidemiology and Natural History of EoE Alex Straumann

8:53 Sp771

When to Consult the Allergist? Seema Aceves

P-118

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Committee Sponsored Symposium 8:30 AM - 10:00 AM 30A San Diego Convention Center

9:15 Sp787

The Role of Autophagy in Innate and Adaptive Immune Responses Vojo Deretic

Sponsored by: Practice Management & Economics Committee; Clinical Practice & Quality Management Committee

AGA Institute Translational Symposium 8:30 AM - 10:00 AM 31BC San Diego Convention Center

GI CODING AND COMPLIANCE UPDATE FOR 2008

Chairs: B. M. Evers, Catia Sternini

Participants will be able to: • Master practice integrity coding in compliance with CMS and other payors; • Recognize the changes in medicare coding and reimbursement policy; and • Learn how to correctly code all procedures to achieve appropriate reimbursement. 8:30 Sp781

GI Coding and Compliance Update for 2008 Kathleen A. Mueller

AGA Institute Committee Sponsored Symposium 8:30 AM - 10:00 AM 26B San Diego Convention Center Chairs: Eamonn M. Quigley, Henry Cohen Sponsored by: International Committee

TRAINING THE GASTROENTEROLOGIST OF THE FUTURE: A GLOBAL PERSPECTIVE Participants will be able to: • Identify how to shape relevant and applicable global standards for GI; • Learn about train the trainer programs (educational programs for those who train in gastroenterology); and • Learn about the skill set of the gastroenterologist of the future and better understand the advantages of training locally.

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors; Gastrointestinal Oncology; Pancreatic Disorders

NEW ADVANCES IN GASTROENTEROPANCREATIC TUMORS: FROM ANIMAL MODELS TO DIAGNOSIS AND TARGETED THERAPY Participants will be able to: • Learn about molecular genetics of gastroenteropancreatic tumors; • Describe the use of animal models for diagnosis and therapy; and • Describe the clinical management of gastroenteropancreatic tumors, including diagnosis, imaging, and biologically targeted novel therapeutic approaches. 8:30 Sp788

Value of Transgenic Mice As An Animal Model for Studying Human Carcinoid Tumors Andrew B. Leiter

9:00 Sp789

Neuroendocrine Tumors: Clinical Features and Current Treatment Options Matthew H. Kulke

9:30 Sp790

Molecular Genetics of Gastroenteropancreatic Neuroendocrine Tumors Daniel Chung

SSAT Conference/Debate/Panel/Symposium 8:30 AM - 10:00 AM 24ABC San Diego Convention Center

8:30 Sp782

One Size Fits All?: Developing Global GI Standards Cihan Yurdaydin

Chair: Michael J. Zinner

8:53 Sp783

Training the Trainers: The WGO Experience James Toouli

SSAT EDUCATION COMMITTEE PANEL: TEACHING SAFETY IN THE OR

9:16 Sp784

The Skill Set of the Gastroenterologist of the Future Guido Costamagna

9:38 Sp785

Providing Training Locally David J. Bjorkman

Participants will be able to: • Understand the need to identify and learn from errors and near misses in the or; • Gain insights into patient safety in the or by comparisons to aviation; and • Discuss the process and documentation to allow non-or personnel in the operating room, as well as understand how empowering the team identifies preventable injury.

AGA Institute Translational Symposium 8:30 AM - 10:00 AM 11 San Diego Convention Center Chairs: John D. Rioux, Averil I. Ma Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease; Growth, Development & Aging ; Gastrointestinal Oncology

AUTOPHAGY IN CROHN'S DISEASE AND MUCOSAL HOMEOSTASIS Participants will be able to: • Identify normal autophagy function; • Identify the abnormalities of this pathway in Crohn's disease; and • Identify the role of autophagy in inflammation, cell necrosis and metabolic stress. 8:30 Sp786

8:30 Sp792

Learning from Errors and Near Misses Caprice Christian Greenberg

8:45 Sp793

Aviation Richard C. Karl

9:00 Sp794

Who Belongs in the OR? (Who's in and Who's Out?) Debra L. Sudan

9:15 Sp795

Team Training Donald W. Moorman

9:30

Q&A

Autophagy in Crohn's Disease and Mucosal Homeostasis Ramnik J. Xavier

P-119

W E D N E S D A Y MAY 21

W E D N E S D A Y MAY 21

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 8:30 AM - 10:00 AM

10 San Diego Convention Center

Chairs: Linda C. Vona-Davis, H. C. Weber

9:00 #898

Procarcinogenic Effect of Bile Salts On Barrett's Esophagus Is Mediated By Increased Activity of NfκB Grzegorz Burnat, Peter Konturek*

9:15 #899

Transformation of Benign Barrett's Epithelial Cells By Repeated Acid and Bile Exposure Over 22-65 Weeks: An In-Vitro Model of Metaplasia to Neoplasia By Environmental Factors Yingxin Kong*, Manisha Bajpai, Diptee A. Kulkarni, Kim M. Hirshfield, Kiron M. Das

9:30 #900

Infliximab-Like Anti-TNFα Antibody Down-Regulates Pro-Carcinogenic Signaling in Barrett's Mucosa Navtej Buttar*, Cathrine J. DeMars, Malini Madhavan, Sumera Ilyas, Thomas C. Smyrk, Ganapathy A. Prasad, Lori S. Lutzke, Kenneth K. Wang

9:45 Sp796

Summary Lecture: Carcinogenesis in Barrett's Esophagus: Acid, Bile Acids, and Inflammation Rhonda F. Souza

Sponsored by: Pancreatic Disorders

BIOLOGY AND PATHOPHYSIOLOGY OF THE PANCREAS Participants will be able to: • Describe the cell biology and physiology of the pancreas; • Review neural regulation of pancreatic secretion; and • Learn the pathogenic role of enzyme activation in the pancreas. 8:30 #890

Intracellular Trypsinogen Activation Induces Pancreatic Acinar Cell Apoptosis and Necrosis While Extracellular Trypsin Activates Nf-κB Baoan Ji*, Sebastian Gaiser, Craig D. Logsdon

8:45 #891

Trypsin Activity in the Mouse Pancreas After Supramaximal Caerulein Stimulation Represents An Inhibitor-Insensitive Isoform Walter Halangk*, Milada Butueva, Markus M. Lerch, Miklós Sahin-Tóth, Thomas Wartmann

9:00 #892

PKD3 Is the Predominant PKD Isoform Expressed in the Exocrine Pancreas and Regulates Hormone-Induced Exocrine Enzyme Secretion L. A. Chen*, Jing Li, Scott R. Silva, Lindsey N. Jackson, Hiroaki Watanabe, Kirk L. Ives, Mark R. Hellmich, B. M. Evers

9:15 #893

Pro-Survival BCL-2 Proteins Regulate Ca2+ Transport in Pancreatic Acinar Cells Julia Gerasimenko*, Irina V. Odinokova, Kai-Feng Sung, Olga A. Mareninova, Moses A. Lee, Lars Fischer, Stephen J. Pandol, Anna S. Gukovskaya

9:30 #894

Localization of Store-Operated CA2+ Channels (Soc), Synchronization of CA2+ Signals, and Apical Bicarbonate (HCO3-) Secretion in Dog Pancreatic Duct Epithelial Cell (PDEC) Monolayers Investigated By Photometry In Vitro Mean-Hwan Kim*, Toan D. Nguyen, Bertil Hille, Duk-Su Koh

9:45 #895

Upregulation of CCK Receptor Affinity of Enteric Cholinergic Neurons Projecting to the Pancreas Is Responsible for CCK Action On Pancreatic Secretion Following Vagotomy Yuanxu Lu, Chung Owyang*

AGA Institute Research Forum 8:30 AM - 10:00 AM

AGA Institute Research Forum 8:30 AM - 10:00 AM

Chairs: Jeffrey M. Lackner, Magnus Simren Sponsored by: Neurogastroenterology and Motility

FUNCTIONAL GI DISORDERS: PSYCHOSOCIAL AND PSYCHOTHERAPEUTIC Participants will be able to: • Better understand the role of altered mood and affect in FGD symptom generation; • Learn about cognitive behavioral treatment approaches; and • Learn about outcome predictors from cognitive behavioral therapy. 8:30 #901

Immune Activation Is Linked to Meal Induced Symptoms and Anxiety and Depression in Healthy Subjects Montri Gururatsakul*, Jenny Persson, Ming-Xian Yan, Edmund C. Khoo, Richard H. Holloway, Nicholas J. Talley, Gerald J. Holtmann

8:45 #902

The Neurophysiology of Gastric Sensation in Functional Dyspepsia: Role of Anxiety Lukas Van Oudenhove*, Joris U. Vandenberghe, Patrick Dupont, Brecht Geeraerts, Guy Bormans, Dominique Vanderghinste, Koen Van Laere, Stijn Dirix, Rita Vos, Koen Demyttenaere, Jan F. Tack

9:00 #903

Rapid Response to Cognitive Behavior Therapy for Irritable Bowel Syndrome: Stepping Into a Stepped Care Model of Treatment Delivery Jeffrey M. Lackner*, Gregory D. Gudleski, Susan S. Krasner, Cathrine Powell, Leonard A. Katz

9:15 #904

What Predicts a Positive Outcome After a Structured Patient Education for Patients with Irritable Bowel Syndrome (IBS)? Gisela Ringstrom*, Stine Storsrud, Hasse Abrahamsson, Magnus Simren

9:30 #905

Long Term Effects of Hypnotherapy in Refractory IBS Perjohan Lindfors*, Henry Nyhlin, Peter Unge, Einar Bjornsson, Hasse Abrahamsson, Magnus Simren

9:45 #906

Anorectal Biofeedback Therapy Improves Bloating in Irritable Bowel Syndrome and Functional Constipation Allison Malcolm*, Ross D. Hansen, Vid P. Suttor, Gillian M. Prott, Lynne Simmons, John E. Kellow

2 San Diego Convention Center

Chairs: Rhonda F. Souza, Kenneth K. Wang Sponsored by: Esophageal, Gastric & Duodenal Disorders

CARCINOGENESIS IN BARRETT'S ESOPHAGUS: ACID, BILE ACIDS, AND INFLAMMATION Participants will be able to: • Learn important factors in Barrett's Esophagus and carcinogenesis. 8:30 #896

Acid Induces DNA Double Strand Breaks Via Reactive Oxygen Species in Benign Barrett's Epithelial Cells. Hui Ying Zhang*, Xi Zhang, Stuart J. Spechler, Rhonda F. Souza

8:45 #897

Bile Acids Cause DNA Damage in Benign Barrett's Epithelial Cells, Which Resist Apoptosis Through Nf-κB Activation. Kathy Hormi-Carver*, Stuart J. Spechler, Rhonda F. Souza

P-120

31A San Diego Convention Center

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 8:30 AM - 10:00 AM

9 San Diego Convention Center

9:00 #915

Wnt-Pathway Activation in Early IBD-Associated Colorectal Carcinogenesis: A Biomarker for Colonic Surveillance Marian M. Claessen*, Frank P. Vleggaar, Marguerite Schipper, Bas Oldenburg, Johan Offerhaus, Peter D. Siersema

9:15 #916

Substance P Mediates Development of Colon Tumors in DSS-Exposed APC/Min Mice and Cultured Human Colon Cancer Cells Hon Wai Koon*, Dezheng Zhao, Hua Xu, Charalabos Pothoulakis

Chairs: Ronnie Fass, Daniel Sifrim Sponsored by: Neurogastroenterology and Motility

GERD, NERD AND OTHER ESOPHAGEAL DISORDERS Participants will be able to: • Better understand the role of esophageal motility; • Better understand the role of the nervous system in modulating esophageal function; and • Learn about new treatments for esophageal disease. 8:30 #907

GERD Alters the Functional Brain Connectivity Models Associated with Acid Stimulation Mark Kern*, Stephen J. Antonik, Rachel Mepani, Adeyemi Lawal, Reza Shaker

8:45 #908

Effects of Vagotomy On the Airway Responses to Esophageal Acidification Ivan M. Lang*, Steven T. Haworth, Bidyut K. Medda, Robert Birkett, Reza Shaker

9:00 #909

Concurrent High-Resolution Impedance and Manometry: Validation of Intraluminal Pressure Gradients As a Predictor of Trans-Sphincteric Flow William J. Bulsiewicz, Sudip K. Ghosh*, John E. Pandolfino, Albert Meek, Peter J. Kahrilas

9:15 #910

Assessing Dysphagia During Esophageal Manometry: How Well Do Liquid and Solid Swallows Reproduce Patients' Symptoms? Daniel Pohl*, Edoardo Savarino, Patrick Janiak, Michael Fried, Radu Tutuian

9:30 #911

In Vivo and In Vitro Characterization of Azd9343, a Novel GABAB Receptor Agonist and Reflux Inhibitor Anders Lehmann*, Thomas Elebring, Jörgen Jensen, Jan P. Mattsson, Karolina A. Nilsson, Pirjo Saransaari, Sverker von Unge

9:45 #912

Signaling in Vanilloid Receptor TRPV1-Mediated Platelet Activating Factor (PAF) Production in Human Esophageal Epithelial Cells Weibiao Cao*, Piero Biancani, Jose Behar, Karen M. Harnett

AGA Institute Research Forum 8:30 AM - 10:00 AM

9:30 #917

Activation of T Lymphocytes and Macrophage Contributes to IL-1β-Induced Gastric Inflammation and Carcinogenesis Shuiping Tu*, Guanglin Cui, Shigeo Takaishi, Govind Bhagat, Evelyn A. Kurt-Jones, James G. Fox, Timothy C. Wang

9:45 #918

Polymorphisms of the DNA Repair Genes Rad51, Xrcc2, Xrcc3 in Inflammatory Bowel Diseases and Colorectal Cancer Maria A. Wisniewska-Jarosinska*, Tomasz Sliwinski, Justyna Lech, Krystyna Stec-Michalska, Jan Chojnacki, Janusz Blasiak

AGA Institute Research Forum 8:30 AM - 10:00 AM

Chairs: Bruce E. Sands, Gerassimos J. Mantzaris Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IMIBD ANTI-TNF THERAPY FOR IBD II. Participants will be able to: • Become familiar with systematic maintenance dosing of infliximab and mucosal healing; • Become familiar with the long-term outcome of patients with Crohn's disease who lost response to infliximab or became intolerant and were then switched to adalimumab; and • Become familiar with the long term outcome of pediatric patients with Crohn's disease treated with infliximab. 8:30 #919

Maintenance Q8 Therapy of Crohn's Disease with Infliximab Is Associated with Endoscopic Mucosal Healing in the Long-Term Fabian Schnitzler*, Herma Fidder, Marc Ferrante, Maja Noman, Gert A. Van Assche, Ilse Hoffman, Severine Vermeire, Paul J. Rutgeerts

8:45 #920

Adalimumab Maintains Long-Term Remission in Moderately to Severely Active Crohn's Disease After Infliximab Failure: 1-Year Follow-Up of Gain Trial Remo Panaccione*, William J. Sandborn, Geert D'Haens, Robert A. Enns, Douglas C. Wolf, Kathleen G. Lomax, Paul F. Pollack

9:00 #921

Long Term Follow-Up of a Cohort of Steroid-Dependent Crohn's Disease Patients Included in a Randomized Trial Evaluating Short Term Infliximab Combined with Azathioprine Laurent Costes*, Jean-Frédéric Colombel, Jean-Yves Mary, Bernard Duclos, Michel Veyrac, Jean-Louis Dupas, JeanCharles Delchier, David Laharie, Jacques Moreau, Guillaume Cadiot, Laurence Picon, Arnaud Bourreille, Marc Lemann

9:15 #922

Adalimumab Maintains Long-Term Remission in Moderately to Severely Active Crohn's Disease Through 2 Years Remo Panaccione*, Jean-Frédéric Colombel, William J. Sandborn, Paul Rutgeerts, Geert D'Haens, Kathleen G. Lomax, Ju Li, Robert Wong, Paul F. Pollack

28ABC San Diego Convention Center

Chairs: Jan-Michael A. Klapproth, Ezra B. Burstein Sponsored by: Gastrointestinal Oncology

IBD, INFLAMMATION AND INFECTION IN GASTROINTESTINAL CANCERS Participants will be able to: • Become familiar with IBD, inflammation and infection in gastrointestinal cancers. 8:30 #913

Characterization of Mucosa-Associated Bacteria Species in Colorectal Biopsies from Normal Mucosa of Patients with and Without Adenomas Xiang Jun Shen, Lauren Burcal, Caroline N. Mpande, Natascha Jenkins, Thomas Randall, John F. Rawls, Robert Sandler, Temitope O Keku*

8:45 #914

Raf-1 Kinase Suppresses Inflammation-Associated Colon Carcinogenesis Karen L. Edelblum*, Mary Kay Washington, D. Brent Polk

6B San Diego Convention Center

P-121

W E D N E S D A Y MAY 21

W E D N E S D A Y

ORAL SESSIONS—SCIENTIFIC SESSIONS 9:30 #923

Infliximab Therapy for Refractory Crohn's Disease (CD) Decreases the Long-Term Need for Bowel Surgery Fabian Schnitzler*, Herma Fidder, Marc Ferrante, Maja Noman, Gert A. Van Assche, Ilse Hoffman, Severine Vermeire, Paul J. Rutgeerts

9:45 #924

Long-Term Outcome Following Infliximab Therapy in Pediatric Patients with Crohn Disease: Results from a Multicenter Study Jeffrey S. Hyams*, Trudy Lerer, Marian D. Pfefferkorn, Subra Kugathasan, Jonathan Evans, Anthony R. Otley, Anne M. Griffiths, Ryan S. Carvalho, David R. Mack, Athos Bousvaros, Joel R. Rosh, Petar Mamula, M. Susan Moyer, Marsha H. Kay, Wallace Crandall, Maria Oliva-Hemker, David Keljo, Neal S. LeLeiko, James Markowitz

MAY 21

AGA Institute Research Forum 8:30 AM - 10:00 AM

6C San Diego Convention Center

Chairs: Lee M. Kaplan, Eric S. Hungness

AGA Institute Research Forum 8:30 AM - 10:00 AM

Chairs: Thomas Brzozowski, Mitchell L. Schubert Sponsored by: Esophageal, Gastric & Duodenal Disorders

NOVEL REGULATORY MECHANISMS FOR UPPER GI TRANSPORT Participants will be able to: • Understand transport mechanisms that regulate acid and bicarbonate secretion. 8:30 #925

Omeprazole Treatment Reduces CO2 Sensitivity in Rat Esophagus Yasutada Akiba*, Misa Mizumori, Jonathan D. Kaunitz

8:45 #926

Muscarinic Acetylcholine Receptor Subtypes Involved in Carbachol-Induced HCO3- Secretion in Mouse Duodenum In Vitro Kazutomo Kita*, Kento Takahashi, Eitaro Aihara, Shinichi Kato, Minoru Matsui, Koji Takeuchi

9:00 #927

Role of Carbonic Anhydrase II in the Murine Duodenal Secretory Response to CO2, Secretagogues, and Mucosal Acidification Markus Sjöblom*, Anurag K. Singh, Anja Krabbenhöft, Brigitte Riederer, Michael P. Manns, Gerolf Gros, Ursula E. Seidler

9:15 #928

Modulation By Muscarinic Acetylcholine Receptor Subtype 4 of Carbachol- Induced Pepsin Secretion in Mice: Relation to D Cells/Somatostatin Nobuaki Takahashi*, Takuya Endo, Kikuko Amagase, Eiji Nakamura, Susumu Okabe, Minoru Matsui, Koji Takeuchi

9:30 #929

Luminal L-Glutamate Enhances Gastroduodenal Mucosal Defenses in Rats Yasutada Akiba*, Misa Mizumori, Jonathan D. Kaunitz

9:45 #930

Gender Differences in Duodenal Bicarbonate Secretion Cause Gender Differences in Human Duodenal Ulcer Biguang Tuo*, Guorong Wen, Jinqi Wei, Yalin Zhang, Hui Dong

Sponsored by: Nutrition & Obesity

MEDICAL, SURGICAL, AND ENDOSCOPIC MANAGEMENT OF OBESITY Participants will be able to: • Become familiar with the medical, surgical, and endoscopic management of obesity. 8:30 #924a

8:45 #924b

Candidate Genes Predict Weight Loss in Response to Sibutramine: A Pharmacogenetic Study in 181 Obese or Overweight Patients April Grudell*, Seth R. Sweetser, Paula Carlson, Duane D. Burton, Maria Vazquez Roque, Deborah J. Eckert, Autumn Braddock, Matthew Clark, Karen Graszer, Sarah Kalsy, Alan R. Zinsmeister, Michael Camilleri Anti-Obesity Surgery in Swedish Men Reduces Morbidity and Lowers Mortality to Population Levels Richard Marsk*, Erik Naslund, Per Tynelius, Jacob Freedman, Finn Rasmussen

9:00 #924c

The Morbidity of Overweight (Above 85th Percentile) in the First Two Years of Life Rana Shibli, Lisa Rubin, Hannah Akons, Ron Shaoul*

9:15 #924d

Occipital C1-C2 Neuromodulation Modifies Eating Behavior and Decreases Body Mass and Fat Stores in Morbidly Obese Patients - Preliminary Results Jacek Sobocki*, Roman M. Herman, Piotr Walega

9:30 #924e

Understanding the Physiology of the Lap-Band Using High Resolution Video Manometry Paul Burton*, Melissa Richards, Geoff Hebbard, Wendy Brown, Paul O'Brien, Sohail Afkari, Cheryl P. Laurie

9:45 #924f

P-122

Esophageal Dysfunction Induced By Gastric Banding Bolus Transit and Manometric Abnormalities Jan Borovicka*, Boudewijn van der Weg, Martin Thurnheer, Bernd Schultes, Claudia Grübel, Patrizia Kuenzler, Daniel Pohl, Michael Fried, Christa Meyenberger, Radu Tutuian

3 San Diego Convention Center

AGA Institute Research Forum 8:30 AM - 10:00 AM

28DE San Diego Convention Center

Chairs: Fergus Shanahan, Faten Aberra Sponsored by: Intestinal Disorders

NOVEL THERAPEUTICS AND DIAGNOSTICS IN INTESTINAL DISORDERS Participants will be able to: • Review novel therapeutics and diagnostics in intestinal disorders. 8:30 #931

Rifaximin Versus Metronidazole for the Treatment of Small Bowel Bacterial Overgrowth Maurizio Gabrielli*, Ernesto Cristiano Lauritano, Emidio Scarpellini, Andrea Lupascu, Veronica Ojetti, Alessia Cazzato, Davide Roccarina, Maria Elena Ainora, Giovanni Cammarota, Michele Serricchio, Giovanni Gasbarrini, Giovanni Ghirlanda, Antonio Gasbarrini

8:45 #932

Lymphocytic Follicles and Aggregates in Colonic Biopsies with Non-Specific Changes Are Related to Duration of Diarrhea Nilesh Shah, Emily F. Shen, Wee Hoe Gan, Tian Ming Tu, Khay Guan Yeoh, Shen Liang, Manuel Salto-Tellez*

ORAL SESSIONS—SCIENTIFIC SESSIONS 9:00 #933

9:15 #934

Small Intestinal Bacterial Overgrowth Recurrence After Rifaximin Therapy Ernesto Cristiano Lauritano*, Maurizio Gabrielli, Lucia Sparano, Alessia Cazzato, Andrea Lupascu, Maria Luisa Novi, Sandra Sottili, Giovanna Vitale, Valentina Cesario, Michele Serricchio, Giovanni Cammarota, Giovanni Gasbarrini, Giovanni Ghirlanda, Antonio Gasbarrini Evaluation of the Efficacy, Safety and Tolerability of Prucalopride (Resolor®) Given Subcutaneously in Patients Undergoing Elective Partial Colectomies Susan Galandiuk*, Greet Beyens, Jannie Ausma, Lieve Vandeplassche

9:30 #935

The Clay Diosmectite in Association with Oral Rehydration Salts Reduces Stool Output and Diarrhea Duration in Children with Acute Watery Diarrhoea: Results of 2 Randomized Double Blind PlaceboControlled Studies Jimmy Lee Kok Foo*, Christophe Dupont, Philippe Garnier, Helene Mathiex-Fortunet, Eduardo Salazar-Lindo

9:45 #936

Determination of Urinary Collection Timeframes to Enhance Measurement of Gastrointestinal (GI) Site Specific Permeability in Adults and Children Mark E. McOmber*, Robert J. Shulman

AGA Institute Research Forum 8:30 AM - 10:00 AM

AGA Institute Topic Forum 8:30 AM - 10:00 AM

Chairs: Brian Feagan, Peter D. Higgins Sponsored by: Clinical Practice; Immunology, Microbiology & Inflammatory Bowel Disease

THE BENEFITS AND RISKS OF MEDICAL AND SURGICAL TREATMENTS FOR INFLAMMATORY BOWEL DISEASE Participants will be able to: • Review the cost effectiveness and impact on quality of life of biological therapies for IBD; • Understand factors which influence outcomes after surgery for IBD; and • Discuss important disease and treatment associated risks in IBD patients. 8:30 #942

The Cost-Effectiveness of Biological Therapies for Crohn's Disease: Markov Cohort Analyses Incorporating UK Patient-Level Cost Data Keith Bodger*, Takashi Kikuchi, Dyfrig A. Hughes

8:45 #943

Impact of Certolizumab Pegol On Quality-Adjusted LifeYears in Two Induction and Maintenance Trials in Patients with Active Crohn's Disease Brian Feagan*, Seng Tan, Martin Brown

9:00 #944

Female Gender and Surgery Lead to Greater Perceived Impact of Inflammatory Bowel Disease (IBD) On Body Image and Sexual Function: A Neglected Issue Kate R. Muller*, Ruth Prosser, Peter A. Bampton, Jane M. Andrews

9:15 #945

Clustering of Immune-Associated Disorders and Adverse Outcomes of Ileal Pouch-Anal Anastomosis Bo Shen*, Feza H. Remzi, Bret Lashner, Rocio Lopez, Elaine Queener, Victor W. Fazio

9:30 #946

Corticosteroids Pose An Increased Risk for Serious Infection: An Interim Safety Analysis of the ENCORE Registry Geert D'Haens*, Jean-Frédéric Colombel, Daniel W. Hommes, Julian Panes, Paul J. Rutgeerts, Anders Ekbom, Usha Barai, Hubert van Hoogstraten, Maria Wiekowski, Christian Antoni

9:45 #947

Risk of Malignancy in Patients with Inflammatory Bowel Disease Treated with Azathioprine or 6-Mercaptopurine: The Cape Town Experience Mashiko Setshedi*, David Epstein, Richard Hift, Trevor A. Winter, Gill A. Watermeyer

32AB San Diego Convention Center

Chairs: Neena S. Abraham, Walter L. Peterson Sponsored by: Clinical Practice

PEPTIC ULCER DISEASE AND UPPER GI BLEEDING Participants will be able to: • Understand the epidemiology and risk factors for upper GI bleeding; • Discuss the impact of implementing a treatment algorithm for H. pylori; and • Review the impact of NSAID switching on adverse GI outcomes. 8:30 #937

Mortality Associated with Gastrointestinal (GI) Bleeding Events: Comparing Short-Term Clinical Outcomes of Patients Hospitalized for Upper GI Bleed and Acute Myocardial Infarction (Ami) in a US Managed Care Setting Gergana Zlateva, Henry J. Henk, Victoria Zarotsky, Byron L. Cryer*, Charles M. Wilcox

8:45 #938

Experience Matters: Higher Hospital Volume Is Associated with Lower Mortality in Acute Non-Variceal Upper Gastrointestinal Hemorrhage Ashwin N. Ananthakrishnan*, Emily L. McGinley, Kia Saeian

9:00 #939

The Etiology, Risk Factors, and Mortality of Gastrointestinal Bleeding After Cardiothoracic Surgery David Oustecky*, Jaydeep Kadam, Ari J. Wiesen, Ilanit Aminow, Kostas Sideridis, Simmy Bank

9:15 #940

Is It Bad to Bleed On a Weekend? a Nationwide Analysis of Upper Gastrointestinal Hemorrhage (UGIH) Ashwin N. Ananthakrishnan*, Emily L. McGinley, Kia Saeian

9:30 #941

What Cumulative H. pylori Eradication Rates Can Be Achieved in Clinical Practice By Adopting First, Second and Third Line Regimens Proposed By the Maastricht III Consensus? Theodore Rokkas*, Panos Sechopoulos, Ioannis Robotis, Georgios Margantinis, Dimitrios Pistiolas

9:45 Sp797

Perspectives in Delivering Care to the Patient with GI Bleed Dennis M. Jensen

33BC San Diego Convention Center

P-123

W E D N E S D A Y MAY 21

W E D N E S D A Y MAY 21

ORAL SESSIONS—SCIENTIFIC SESSIONS SSAT Plenary Session 8:30 AM - 10:00 AM

25 San Diego Convention Center

Chairs: Deborah Nagle, Edward E. Whang SSAT TRANSLATIONAL SCIENCE PLENARY (PLENARY SESSION VI) Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 8:30 #948

8:45 #949

9:00 #950

9:15 #951

9:30 #952

9:45 #953

The Role of ERCC1 RNA Expression in Blood As a NonInvasive Predictor of Response to Neadjuvant RadioChemotherapy in Patients with Locally Advanced Cancer of the Esophagus Jan Brabender*, Daniel Vallböhmer, Frederike C. Ling, Andreas C. Hoffmann, Georg Lurje, Elfriede Bollschweiler, Arnulf H. Hölscher, Paul M. Schneider, Ralf Metzger Strong Prognostic Value of Nodal Microinvolvement in Patients with Carcinoma of the Papilla of Vater Receiving No Adjuvant Chemotherapy Dean Bogoevski*, Paulus G. Schurr, Jussuf T. Kaifi, Guell Cataldegirmen, Oliver Mann, Yogesh K. Vashist, Emre F. Yekebas, Jakob R. Izbicki The Prognostic Superiority of Log Odds of Lymph Nodes in Stage III Colon Cancer Jiping Wang*, James M. Hassett, Merril T. Dayton, Mahmoud N. Kulaylat High Expression of Heparanase Is Significantly Associated with Dedifferentiation and Lymph Node Metastasis in Patients with Pancreatic Ductal Adenocarcinomas and Correlated to PDGFA and Via HIF1a to HB-EGF and bFGF Andreas C. Hoffmann*, Ryutaro Mori, Daniel Vallbohmer, Jan Brabender, Uta Drebber, Stephan E. Baldus, Mizutomo Azuma, Ralf Metzger, Christina Hoffmann, Arnulf H. Hölscher, Kathleen D. Danenberg, Klaus L. Prenzel, Peter V. Danenberg VEGF Gene Therapy Improves Anastomotic Healing in the Gastrointestinal Tract: Applications in Esophageal Surgery Kristian Enestvedt*, Shelley R. Winn, Brian S. Diggs, Luke Hosack, Barry Uchida, Robert W. O'Rourke, Blair A. Jobe Loss of Heterozygosity Portends Poor Survival of Patients with Resected Periampullary Cancer Jan Franko*, Alyssa M. Krasinskas, Marina N. Nikiforova, Yuri E. Nikiforov, Steven J. Hughes, Kenneth K. Lee, David L. Bartlett, Herbert Zeh, Arthur J. Moser

DDW Combined Clinical Symposium 10:30 AM - 12:00 PM 20A San Diego Convention Center Chairs: Marcia R. Cruz-Correa, Peter Marcello Sponsored by: ASGE; SSAT; AGA Institute

THE BIG POLYP: WHO OWNS IT? Participants will be able to: • Review the recent epidemiology and discuss risk assessment in lower GI bleeding; • Consider the role of urgent colonoscopy across the spectrum of patients hospitalized with lower GI bleeding; and • Understand the advantages and disadvantages of radiologic approaches to the management of lower GI bleeding. 10:30 Sp799

Endoscopic Mucosal Resection for Colorectal Polyps Michael B. Wallace

11:00 Sp800

Transendoscopic Mucosal Resection for Rectal Polyps Theodore J. Saclarides

11:30 Sp801

Endoscopic Submucosal Dissection for Colorectal Polyps: How I Do It Mainor R. Antillon

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM 32AB San Diego Convention Center Chairs: Joseph H. Sellin, Henry J. Binder Sponsored by: Intestinal Disorders; Clinical Practice; Growth, Development & Aging ; Neurogastroenterology and Motility

DIFFICULT DIARRHEAS Participants will be able to: • Appreciate the complexities of drug-induced diarrheas; • Explain the testing for bacterial overgrowth and its relationship to diarrhea; and • Identify the role of bile salts in diarrhea. 10:30 Sp802

Drug-Induced Diarrheas Joseph H. Sellin

11:00 Sp803

Bile Salts and Diarrhea-Connected or Not Lawrence R. Schiller

11:30 Sp804

Clostridium difficile Induced Diarrhea Donald P. Kotler

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM 1 San Diego Convention Center Chairs: Douglas A. Drossman, David M. Grunkemeier

AGA Institute Committee Sponsored Symposium 10:30 AM - 11:30 AM 31A San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility; Clinical Practice; Hormones, Transmitters, Growth Factors, & Their Receptors

EVIDENCE-BASED ANSWERS AT THE POINT-OF-CARE

NARCOTIC BOWEL SYNDROME

Participants will be able to: • Identify the frequency of clinical questions that arise in their everyday practice; and • Describe how point-of-care resources can be used to get evidencebased answers.

Participants will be able to: • Be familiar with narcotic bowel syndrome clinical manifestations related to public health.

10:30 Sp798

P-124

Evidence-Based Answers At the Point-of-Care Benjamin Krevsky

10:30 Sp805

Clinical Features and Diagnosis of Narcotic Bowel Syndrome Lin Chang

ORAL SESSIONS—SCIENTIFIC SESSIONS 10:52 Sp806

Pathophysiology of Hyperalgesia with Chronic Narcotic Use Mark R. Hutchinson

11:14 Sp807

The Epidemic of Narcotic Use in the US: A Public Health Problem Nicholas J. Talley

11:37 Sp808

Treatment Strategies Douglas A. Drossman

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM 5 San Diego Convention Center Chairs: Aurora D. Pryor, Mark H. DeLegge Sponsored by: Clinical Practice; Nutrition & Obesity ; Liver & Biliary ; Esophageal, Gastric & Duodenal Disorders; Imaging & Advanced Technology

OBESITY, BARIATRIC SURGERY, AND THE GASTROENTEROLOGIST Participants will be able to: • Appreciate the varied nutrition consequences of bariatric surgery; • Review endoscopic treatments for complications of fistula and stricture following gastric bypass surgery; and • Describe the new potential endoscopic therapies for obesity.be familiar with the various bariatric surgery procedures.

AGA Institute Translational Symposium 10:30 AM - 12:00 PM 3 San Diego Convention Center Chairs: Basil Rigas, Yoshiro Niitsu Sponsored by: Gastrointestinal Oncology; Imaging & Advanced Technology

ABERRANT CRYPT FOCI (ACF) IN HUMANS: ROLE IN CARCINOGENESIS AND ENDPOINTS IN CHEMOPREVENTION TRIALS

MAY 21

Participants will be able to: • State the clinical implications of aberrant crypt foci (ACF) in human cancers; • Describe the methods of detection of ACF; and • Identify the role of ACF in determining risks of colon cancer. 10:30 Sp816

ACF: Detection, Genetic Abnormalities, and Clinical Applications Tetsuji Takayama

11:00 Sp817

High-Magnification Chromoscopic Colonoscopy in Early Cancer Detection David P. Hurlstone

11:30 Sp818

ACF and Risks of Colorectal Cancer Theresa Pretlow

10:30 Sp809

Emerging Endoscopic Approaches to Obesity Mark H. DeLegge

AGA Institute Translational Symposium 10:30 AM - 12:00 PM 28DE San Diego Convention Center

10:53 Sp810

Treatment of Post-Bariatric Surgery Fistulas and Strictures Christopher C. Thompson

Chairs: David Yule, Stephen J. Pandol

11:16 Sp811

The ABC's of Post-Bariatric Surgery Vitamin and Mineral Deficiencies Mark T. DeMeo

11:38 Sp812

Bariatric Surgery - What Does the Gastroenterologist Need to Know? Bruce D. Schirmer

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM 31BC San Diego Convention Center Chairs: Robert H. Squires, Carlos O. Esquivel Sponsored by: Growth, Development & Aging; In collaboration with NASPGHAN; Clinical Practice; Intestinal Disorders; Esophageal, Gastric & Duodenal Disorders

Sponsored by: Pancreatic Disorders; Imaging & Advanced Technology ; Clinical Practice; Liver & Biliary

ENZYME ACTIVATION IN THE PATHOGENESIS OF PANCREATITIS Participants will be able to: • Identify the mechanisms by which pancreatic injury causes zymogen activation and its relationship to the pathogenesis of acute pancreatitis. 10:30 Sp819

Lysosomal - Zymogen Interactions in Pancreatitis Markus M. Lerch

11:00 Sp820

Trypsin Inhibitors and Pancreatitis Miklós Sahin-Tóth

11:30 Sp821

Trypsin Activation in Pancreatitis Craig D. Logsdon

SMALL INTESTINAL TRANSPLANT Participants will be able to: • Review the array of clinical concerns involved in management of transplant patients. 10:30 Sp813

Indications and Evaluations Marvin E. Ament

11:00 Sp814

Surgical Management George V. Mazariegos

11:30 Sp815

Outcome and Complications Simon P. Horslen

W E D N E S D A Y

P-125

W E D N E S D A Y MAY 21

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 10:30 AM - 12:00 PM

2 San Diego Convention Center

11:00 #962

Empirical Proton Pump Inhibitor Therapy or Helicobacter pylori “Test and Treat” in the Initial Management of Dyspepsia? An Individual Patient Data Meta-Analysis Alexander C. Ford*, Paul Moayyedi, Richard F. Logan, Michelle Qume, Brendan C. Delaney

11:15 #963

Influence of PPI Run-in, pH Monitoring and Nutrient Tolerance On Efficacy Outcomes of Acotiamide Hydrochloride (YM443), a Novel Acetylcholine Esterase Inhibitor, in Functional Dyspepsia Jan F. Tack*, Nicholas J. Talley, Donna L. Kowalski, Mary Ann Borton, Abhijit Barve

11:30 #964

Homozygous TRPV1 315C Influences the Susceptibility of Japanese People to Functional Dyspepsia Tomomitsu Tahara*, Tomiyasu Arisawa, Tomoyuki Shibata, Masakatsu Nakamura, Hiroshi Nakano, Ichiro Hirata

11:45 Sp822

State-of-the-Art Overview Michael D. Crowell

Chairs: Scott M. Tenner, Santhi S. Vege Sponsored by: Pancreatic Disorders

ADVANCES IN ACUTE AND CHRONIC PANCREATITIS Participants will be able to: • Understand the importance of early recognition of severe acute pancreatitis in directing management; and • Describe the etiologies of pancreatitis in pediatric populations. 10:30 #954

10:45 #955

Slower Rate of Initial Fluid Resuscitation in Severe Acute Pancreatitis Is a Risk for in-Hospital Mortality Timothy B. Gardner*, Suresh T. Chari, Bret T. Petersen, Mark D. Topazian, Jonathan E. Clain, Randall K. Pearson, Michael J. Levy, Michael G. Sarr, Santhi Swaroop Vege A Prospective Validation of the Bedside Index for Severity in Acute Pancreatitis (Bisap) Score in Assessing Mortality in Acute Pancreatitis Vikesh Singh*, Bechien U. Wu, Kathryn Repas, Richard S. Johannes, Peter A. Banks

11:00 #956

Enteral Nutrition Is Superior to Total Parenteral Nutrition in Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis Nadim S. Jafri*, Suhal S. Mahid, Swapna K. Gopathi, Carlton A. Hornung, Susan Galandiuk, Stephen A. McClave

11:15 #957

Pediatric Pancreatitis: Epidemiology, Etiologies, and Recurrence, a Retrospective Study Sahibzada U. Latif*, Alexander Park, Ahsan U. Shah, Jianmin Tian, Allen L. Hsiao, Dinesh Pashankar, Vineet Bhandari, Anil B. Nagar, Sohail Z. Husain

11:30 #958

Enteropathy- a New Finding in Cystic Fibrosis Steven Werlin, Ishay Benuri-Silbiger, Limor Cohen, Netta Malka, Eitan Kerem, Micha Aviram, Lea Bentur, Huda Mussaffi, Samuel N. Adler, Ingvar Bjarnasson, Ari Bergwerk, Michael Wilschanski*

11:45 #959

AGA Institute Research Forum 10:30 AM - 12:00 PM

Chairs: Sunanda V. Kane, Corey A. Siegel Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IMIBD TOXICITY FROM IMMUNOSUPPRESSION IN PATIENTS WITH IBD. Participants will be able to: • Become familiar with the association of immunosuppressive therapy and cervical dysplasia in patients with IBD; • Become familiar with the association of corticosteroids and serious infections in patients with IBD; and • Become familiar with the association of immunosuppressive therapy and lymphoma in patients with IBD. 10:30 #965

Risk of Cervical Abnormalities in Women with IBD: A Population-Based Nested Case-Control Study Harminder Singh*, Alain Demers, Zoann Nugent, Salaheddin M. Mahmud, Erich V. Kliewer, Charles N. Bernstein

10:45 #966

Prevalence of Abnormal PAP Smears in Patients with Inflammatory Bowel Disease On Immune Modulator Therapy Thomas E. Lyles*, Robert A. Oster, Alexandra Gutierrez

11:00 #967

Cervical Dysplasia and Inflammatory Bowel Disease: No Effect of Disease Status or Immunosuppressants On Analysis of 2,199 Smear Records Charles W. Lees*, Julia Critchley, Nellie M. Chee, Alan G. Shand, Ian D. Arnott, Jack Satsangi

11:15 #968

Infliximab Use in Patients with Inflammatory Bowel Disease and the Risk of Serious Bacterial Infections Brian Bressler*, Joshua R. Korzenik, Claire Canning, Daniel Solomon, Sebastian Schneeweiss

11:30 #969

Immunosuppressant Medications and Mortality in Inflammatory Bowel Disease James D. Lewis*, Joel M. Gelfand, Andrea B. Troxel, Kimberly A. Forde, Craig Newcomb, Hopiy Kim, David J. Margolis, Brian L. Strom

11:45 #970

Risk of Lymphoma Associated with Anti-TNF Agents for the Treatment of Crohn's Disease: A Meta-Analysis Corey A. Siegel*, Sadie M. Marden, Sarah M. Persing, Robin J. Larson, Bruce E. Sands

A Large Cohort Study of the Relationship Between Hyperparathyroidism and Pancreatitis Gourisankar Degala*, Fadi Antaki, Gregory Olds

AGA Institute Research Forum 10:30 AM - 12:00 PM

9 San Diego Convention Center

Chairs: Guy E. Boeckxstaens, Michael D. Crowell Sponsored by: Esophageal, Gastric & Duodenal Disorders

FUNCTIONAL DYSPEPSIA: EMPIRIC AND NOVEL THERAPIES Participants will be able to: • Increase understanding of treatments for dyspepsia. 10:30 #960

Effect of a Community Screening and Eradication Program for Helicobacter pylori Infection On Consultations for Dyspepsia: Seven Year Follow-Up of the Bristol Helicobacter Project J Athene Lane*, Richard F. Harvey, Liam J. Murray, Matthias Egger, Ian Harvey, Prakash Nair, Jenny Donovan

10:45 #961

Empirical PPI Treatment in Dyspepsia: Evaluation of Symptoms Predicts Response Villy Meineche-Schmidt*, Peter Bytzer, Erik Christensen

P-126

6A San Diego Convention Center

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 10:30 AM - 12:00 PM

24ABC San Diego Convention Center

AGA Institute Research Forum 10:30 AM - 12:00 PM

26B San Diego Convention Center

Chairs: Sean P. Colgan, Silvio Danese

Chairs: Beverley Greenwood-Van Meerveld, Tor Savidge

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

Sponsored by: Neurogastroenterology and Motility

INTESTINAL EPITHELIAL CELL IMMUNE FUNCTION Participants will be able to: • Understand how tight junction proteins maintain mucosal homeostasis in IBD; • Understand how regulation of TLR signaling influences intestinal epithelial cells; and • Understand how micro sRNA regulate chemokine expression in IBD. 10:30 #971

10:45 #972

11:00 #973

Knock Down of BMF Maintains Survival of Primary Intestinal Epithelial Cells Martin Hausmann*, Silvia Kellermeier, Claudia Hofmann, Florian Obermeier, Werner Falk, Jürgen Schölmerich, Gerhard Rogler Unique Role of Junctional Adhesion Molecule-a in Maintaining Mucosal Homeostasis in Inflammatory Bowel Disease Stefania Vetrano*, Maria Rescigno, Maria Rosaria Cera, Andrea Doni, Carmen Correale, Massimo C. Fantini, Andreas Sturm, Elena Borroni, Alessandro Repici, Cristiano Rumi, Massimo Locati, Alberto Malesci, Elisabetta Dejana, Silvio Danese A20 Is An Early Responsive Negative Regulator of TollLike Receptor Signaling in Intestinal Epithelial Cells During Inflammation Naoki Oshima*, Shunji Ishihara, Mohammad A. Rumi, Md M. Aziz, Yoshiyuki Mishima, Chikara Kadota, Ichiro Moriyama, Aya Ohtani, Akihiko Oka, Yong-Yu Li, Yasunori Kadowaki, Yuji Amano, Yoshikazu Kinoshita

11:15 #974

Characterization of Peptidoglycan Transcytosis Across Intestinal Epithelia Heng-Fu Bu*, Yi Tang, Xiao Wang, Vjola Koti, Xiao-Di Tan

11:30 #975

The Regulation of Macrophage Inhibitory Peptide-2α in Colonic Epithelial Cells By MicroRNAs and Their Expression in Ulcerative Colitis Feng Wu, Anil Trindade, Michelle N. Zikusoka, Theodore M. Bayless, Steven R. Brant, John H. Kwon*

11:45 #976

Downregulation of Klotho in Experimental Colitis: The Role of TNFα and IFN-γ Robert D. Thurston, Claire B. Larmonier, Jennifer K. Uno, Monica T. Midura-Kiela, Pawel R. Kiela*, Fayez K. Ghishan

NEURONS AND GLIA IN INFECTIOUS AND INFLAMMATORY DISEASE

MAY 21

Participants will be able to: • Understand the role of neurons and glia in inflammation. 10:30 #977

JC Virus Infects the Enteric Glia of Patients with Chronic Idiopathic Intestinal Pseudo-Obstruction Michael Selgrad*, Roberto De Giorgio, Lucia Fini, Rosanna Cogliandro, Sharenda Williams, Vincenzo Stanghellini, Giovanni Barbara, Marcello Tonini, Roberto Corinaldesi, Robert M. Genta, Ajay Goel, C. R. Boland, Luigi Ricciardiello

10:45 #978

Mucosal Biopsies from IBS Patients Release Mediators That Sensitize Human Enteric Nervous System (ENS) Sabine Buehner*, Qin Li, Sheila Vignali, Florian Zeller, Giovanni Barbara, Roberto De Giorgio, Vincenzo Stanghellini, Klaus Michel, Michael Schemann

11:00 #979

Enteric Glial Cells Promote Neuroprotection Against Oxidative Stress and Apoptosis: Evidence for Effects of Reduced Glutathione Hind Abdo*, Pascal Derkinderen, Priya Gomes, Julien Chevalier, Philippe Aubert, Damien Masson, Pieter Vanden Berghe, Michel Neunlist, Jean Paul Galmiche, Bernard Lardeux

11:15 #980

S Nitrosoglutathione Protects Intestinal Epithelial Barrier During Aggression By Shigella Flexneri Mathurin Flamant*, Arnaud Bourreille, Philippe Aubert, Caroline Trang, Emmanuel Coron, Guillaume Meurette, Elizabeth Cassagnau, Philippe Sansonetti, Jean Paul Galmiche, Tor Savidge, Michel Neunlist

11:30 #981

Enteric Glial Protein S100B Up-Regulation Stimulates Nitric Oxide Production in Ulcerative Colitis Carla Cirillo*, Giovanni Sarnelli, Giuseppe Esposito, Michela Grosso, Raffaella Petruzzelli, Guido Mandarini, Teresa Iuvone, Rosario Cuomo

11:45 #982

Prolonged IL-1β Exposure of Jejunal Myenteric Neurons Alters Their Intracellular CA2+ Response to Oral Electrical Tract Stimulation and Serotonin Application Sebastien Kindt*, Pieter Vanden Berghe, Jan F. Tack

AGA Institute Research Forum 10:30 AM - 12:00 PM

30A San Diego Convention Center

Chairs: H. Christian Weber, Vazhaikkurichi M. Rajendran Sponsored by: Nutrition & Obesity

NUTRIENT ABSORPTION AND REGULATION OF FOOD INTAKE Participants will be able to: • Learn more about the various aspects of nutrient absorption and the regulation of food intake. 10:30 #983

W E D N E S D A Y

Molecular Regulation of the Menkes Copper ATPase (Atp7a) During Iron-Deficiency James F. Collins

P-127

W E D N E S D A Y MAY 21

ORAL SESSIONS—SCIENTIFIC SESSIONS 10:45 #984

Suppression of LPS and IL-6 Signaling By Iron Deficiency Alters Expression of the Intestinal Iron Absorption Regulator Hepcidin Deepak Darshan, David M. Frazer, Sarah J. Wilkins, Gregory J. Anderson*

11:00 #985

Ezetimibe Reduces Intestinal Absorption of Fatty Acid By Inhibiting the Niemann-Pick C1 Like 1 Protein (NPC1L1) Pathway in Mice Helen H. Wang, Piero Portincasa, Patrick Tso, David Q. Wang*

11:15 #986

The Effects of Intestinal Fat Delivery On Satiety, Food Intake and Gastrointestinal Function Depend On Intestinal Site and Lipid Droplet Size Jeroen Maljaars*, Robert van der Wal, Edward Haddeman, Harry PF Peters, Ad A. Masclee

11:30 #987

des-acyl Ghrelin Suppresses Food Intake and Body Weight Gain in Adult Obese Zucker Rats Andreas Stengel*, Anna-Sophia Wisser, Peter Kobelt, Miriam Goebel, Bertram Wiedenmann, Burghard F. Klapp, Yvette Tache, Hubert Monnikes

11:45 #988

Long-Term Appetite Suppression Following Roux-en-Y Gastric Bypass (Rygb) Edward Lin*, Reena Oza-Frank, Eman A. El-Bassuoni, Adeola Ayeni, Thomas R. Ziegler, John F. Sweeney, Nana Gletsu-Miller

AGA Institute Research Forum 10:30 AM - 12:00 PM

AGA Institute Research Forum 10:30 AM - 12:00 PM

Chairs: Stuart J. Spechler, Stephen J. Meltzer Sponsored by: Esophageal, Gastric & Duodenal Disorders

THE MOLECULAR BIOLOGY OF ADENOCARCINOMA IN BARRETT'S ESOPHAGUS Participants will be able to: • Understand new molecular mechanisms of carcinogenesis in Barrett's Esophagus. 10:30 #995

Proteomic Analysis Separates Barrett's Esophagus and Esophageal Adenocarcinoma from Healthy Controls By Distinct T Cell Populations Uta Berndt*, Sebastian Bartsch, Lars Philipsen, Bertram Wiedenmann, Marcus Haemmerle, Heiko Pohl, Andreas Sturm

10:45 #996

Implication of Notch Signaling and CDX-2 Expression in Barrett's Carcinogenesis Peter Konturek*, Gregor Burnat, Tilman Rau, Eckhart G. Hahn

11:00 #997

Sonic Hedgehog Gene Expression in Barrett's Esophagus and Esophageal Adenocarcinoma Daniel S. Oh*, Steven R. DeMeester, Ryutaro Mori, Hidekazu Kuramochi, Jeffrey A. Hagen, John C. Lipham, Parakrama Chandrasoma, Peter V. Danenberg, Kathleen D. Danenberg, Tom R. DeMeester

11:15 #998

Tribbles Homolog 3 (TRB3) a Novel Regulator of Bile Acid Signaling in Esophageal Cells That May Be Lost in Esophageal Carcinogenesis Shane P. Duggan*, Fiona Behan, Ramon Vicente, Aideen Long, Dermot P. Kelleher

11:30 #999

Local Reduction of CIS Protein Activity Is Associated with Increased Neoplasia Risk in Barrett's Esophagus Min Chen*, Herman van Dekken, Lisette G. Capelle, Anouk Van de Winkel, Bing Xia, Johannes G. Kusters, Christien J. van der Woude, Ernst J. Kuipers, Monique M. Gerrits

11:45 Sp823

Summary Lecture: The Molecular Biology of Adenocarcinoma in Barrett's Esophagus Stephen J. Meltzer

4 San Diego Convention Center

Chairs: Paul J. Limburg, Francis M. Giardiello Sponsored by: Gastrointestinal Oncology

PREVENTION, CHEMOPREVENTION AND THERAPIES OF GASTROINTESTINAL CANCERS Participants will be able to: • Become familiar with prevention, chemoprevention and therapies of gastrointestinal cancers. 10:30 #989

Eradication of Helicobacter pylori for the Incidence of Metachronous Gastric Cancer After Endoscopic Resection Kazutoshi Fukase*, Mototsugu Kato, Shogo Kikuchi, Masahiro Asaka

10:45 #990

Mechanisms of Growth Inhibition of Chemo-Surviving Colon Cancer Cells By Curcumin and Resveratrol Bhaumik B. Patel*, Deep-Shikha Gupta, Vivek Sengupta, Adhip P. N. Majumdar

11:00 #991

Effect of NSAID Use After Randomized Aspirin Treatment On the Risk of Colorectal Adenomas Maria V. Grau*, Robert Sandler, John A. Baron

11:15 #992

Unraveling Novel Mechanisms By Which the CD24 Oncogene Serves As a Target for Colorectal and Pancreatic Cancer Treatment, Via Down-Regulation By Monoclonal Antibodies or SIRNA Eyal Sagiv, Shiran Shapira, Diana Kazanov, Inna Naumov, Kraus Sarah, Nadir Arber*

11:30 #993

11:45 #994

P-128

Tissue Transglutaminase Downregulation Potentiates Gemcitabine Efficacy and Blocks Pancreatic Cancer Growth In Vivo Sushovan Guha*, Amit Verma, Kapil Mehta Long-Term Users of Statins Are Not Protected Against Colorectal Cancer Harminder Singh*, Donna Turner, Salaheddin M. Mahmud, Lin Xue, Anita L. Kozyrskyj, Alain Demers, Charles N. Bernstein

33BC San Diego Convention Center

AGA Institute Topic Forum 10:30 AM - 12:00 PM

30B San Diego Convention Center

Chairs: Martin F. Kagnoff, Detlef Schuppan Sponsored by: Intestinal Disorders; Immunology, Microbiology & Inflammatory Bowel Disease

CELIAC DISEASE MECHANISMS Participants will be able to: • Delineate the mechanisms of celiac disease. 10:30 #1000

Gliadin Elicits An Innate Immune Response in Monocytic and Intestinal Epithelial Cells Via the MyD88 Pathway Yvonne Junker*, Detlef Schuppan

10:45 #1001

Extracellular Transglutaminase 2 Is Catalytically Inactive, But Is Transiently Activated Upon Tissue Injury in the Small Intestine Matthew Siegel, Pavel Strnad*, Richard E. Watts, Kihang Choi, Bana Jabri, Guido Adler, Bishr Omary, Chaitan Khosla

ORAL SESSIONS—SCIENTIFIC SESSIONS 11:00 #1002

Role of Intestinal Barrier Modulation By Non-Steroidal Anti-Inflammatory Drugs in Gluten-Induced Epithelial Damage in HLA-Dq8/Hcd4 Transgenic Mice Jane Natividad, Jennifer Jury, Yolanda Sanz, Manuel A. Silva, Waliul I. Khan, Pinchang Yang, Chella S. David, Joseph a. Murray, Mary H. Perdue, Elena F. Verdu*

11:15 #1003

Expansion of FOXP3+ T Cells in Overt and Potential Coeliac Disease and In Vitro Gliadin-Challenged Mucosa: FACS and Immunohistochemical Analysis Delia Zanzi, Rosita Stefanile, Virginia Salvati, Melissa Borrelli, Gaetano Iaquinto, Sara Santagata, Laura Iaffaldano, Giulia Corrado, Salvatore Auricchio, Riccardo Troncone*, Giuseppe Mazzarella

11:30 #1004

11:45 #1005

11:45 #1011

AGA Institute Topic Forum 10:30 AM - 12:00 PM

Chairs: Karen Madsen, Levinus A. Dieleman Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease; Nutrition & Obesity

Prevotella Species from the Small Bowel of Untreated Celiac Patients Suppress Production of Systemic Inflammatory Cytokines in Dq8 Transgenic Murine Model Susan H. Barton*, Eric Marietta, Melissa J. Jacobson, Shadi Rashtak, Joseph a. Murray

Participants will be able to: • Understand the mechanisms by which various probiotic species exert protective activities; • Understand the signaling pathways activated by probiotic bacteria; and • Recognize that certain probiotic species can potentiate experimental colitis.

10 San Diego Convention Center

PROBIOTICS: MECHANISMS OF ACTION AND EFFICACY IN GASTRIC AND INTESTINAL INFLAMMATION

10:30 #1012

Gastroprotective Activity of Probiotic Bacteria Lactobacillus and Escherichia coli Nissle 1917 Against Acute Gastric Mucosal Injury in the Rat Stomach Is Mediated By Endogenous Prostaglandins and Nitric Oxide (No) Tomasz Brzozowski*, Peter C. Konturek, Slawomir Kwiecien, Robert Pajdo, Agata Ptak-Belowska, Aneta Targosz, Urszula Szczyrk, Wladyslaw Bielanski, Stanislaw J. Konturek, Wieslaw W. Pawlik

10:45 #1013

Effect of a Probiotic Preparation (VSL #3) On Induction and Manteinance of Remission in Children with Ulcerative Colitis Erasmo Miele*, Robert Baldassano, Filomena Pascarella, Eleonora Giannetti, Riccardo Troncone, Annamaria Staiano

11:00 #1014

Lactobacillus Reuteri Promoted Helicobacter HepaticusAssociated Typhlocolitis in Gnotobiotic IL-10 Deficient Mice Mark T. Whary*, Nancy S. Taylor, Yan Feng, Zhongming Ge, Sureshkumar Muthupalani, James G. Fox

11:15 #1015

Post-Translational Inhibition of IP-10 Protein Secretion in Intestinal Epithelial Cells Through ERK-Dependent and Ubiquitin-Mediated Mechanisms: Bacterial StrainSpecific Effects of VSL#3 Gabriele Hörmannsperger*, Thomas Clavel, Dirk Haller

11:30 #1016

Probiotics Modulate the Distribution of Dendritic Cell Subsets in the Intestinal Mucosa Xiao Wang*, Heng-Fu Bu, Vjola Koti, Maurice R. O'Gorman, Xiao-Di Tan

11:45 #1017

The Metabolic Activity of the Enteric Microbiota Influences the Fatty Acid Composition of Host Tissues Rebecca A. Wall*, Reynolds P. Ross, Fergus Shanahan, Liam O'Mahony, Caitlin O'Mahony, Eamonn M. Quigley, Barry Kiely, Gerald Fitzgerald, Catherine Stanton

Chairs: Deborah A. Fisher, Douglas J. Robertson Sponsored by: Clinical Practice; Gastrointestinal Oncology

COLORECTAL CANCER SCREENING: PRACTICAL ISSUES Participants will be able to: • Review factors which can interfere with effective colorectal cancer screening; • Understand the effects of time delays between FOBT and colonoscopy; and • Review the risks of renal dysfunction after oral phosphosoda preparation.

10:45 #1007

11:00 #1008

6B San Diego Convention Center

Celiac Disease Model in Rag1-/- Mice Adoptively Transferred with Gliadin-Sensitized Effector/Memory T Cells, Challenged with Oral Gluten Tobias Freitag*, Svend Rietdijk, Yvonne Junker, Yury Popov, Atul K. Bhan, Ciaran P. Kelly, Cox Terhorst, Detlef Schuppan

AGA Institute Topic Forum 10:30 AM - 12:00 PM

10:30 #1006

Oral Phosphosoda for Bowel Preparation Before Colonoscopy: Renal Toxicity in Elderly Patients with Diabetes Mellitus Hanumantha R. Ancha*, James Post, William Bauman, Maher Jerudi, Kristel K. Hunt, Spencer Shaw, Alan S. Rosman, Marinella Galea, Ann M. Spungen, Ashwani K. Singal, Mark A. Korsten

Time from Positive Screening Fecal Occult Blood Test to Colonoscopy and Risk of Neoplasia Ziad F. Gellad*, Daniel Almirall, Dawn Provenzale, Deborah A. Fisher Determinants and Effect of Lag Time Before Colorectal Cancer Diagnosis Hashem B. El-Serag*, Julia Wattacheril, Benjamin D. Havemann, Linda K. Green, Jennifer R. Kramer, Peter Richardson Time to Diagnosis of Colorectal Cancer in the VA System Deborah A. Fisher*, Leah Z. Conner, Steven Grambow, David Abbott, Dawn Provenzale

11:15 #1009

Timely Access and Quality of Care in Colorectal Cancer: Are They Related? Yarrow McConnell*, Karen Inglis, Geoff Porter

11:30 #1010

Prevention of Colorectal Cancer By Colonoscopy Is the Most Likely Screening Strategy to Offset Escalating Treatment Costs Ann G. Zauber*, Iris Lansdorp-Vogelaar, Janneke Wilschut, Amy B. Knudsen, John I. Allen, Joel V. Brill, Marjolein van Ballegooijen, Sidney J. Winawer, Karen M. Kuntz

P-129

W E D N E S D A Y MAY 21

W E D N E S D A Y MAY 21

ORAL SESSIONS—SCIENTIFIC SESSIONS SSAT Plenary Session 10:30 AM - 12:00 PM

25 San Diego Convention Center

Chairs: Oscar J. Hines, Blair A. Jobe SSAT PLENARY SESSION VII Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 10:30 #1018

10:45 #1019

11:00 #1020

Long-Term Results After Minimally Invasive Repair of Giant Paraesophageal Hernia in 105 Patients Katie S. Nason*, James D. Luketich, Rodney J. Landreneau, Irfan Qureshi, Samuel B. Keeley, Shannon E. Trainor, Manisha Shende, Arjun Pennathur Perioperative Treatment with Infliximab (IFX) in Patients with Crohn's (CD) and Ulcerative Colitis (UC) Is Not Associated with Increased Rate of Postoperative Complications Hiroko Kunitake*, Richard Hodin, Paul C. Shellito, Bruce E. Sands, Joshua R. Korzenik, Liliana Bordeianou Use of Infliximab Within Three Months Prior to Ileocolonic Resection Is Associated with Significant Adverse Postoperative Outcomes in Crohn's Patients Kweku A. Appau*, Victor W. Fazio, James M. Church, Bo Shen, Feza H. Remzi, Scott A. Strong, Bret Lashner, Takayuki Yamamoto, Paris P. Tekkis, Jeffery Hammel, Ravi P. Kiran

11:15 #1021

Selective Management of Iatrogenic Colonoscopic Perforations Dimitrios V. Avgerinos*, Omar H. Llaguna, Andrew Y. Lo, I. Michael Leitman

11:30 #1022

Pancreatic Fistula Rates After 442 Distal Pancreatectomies: Staplers Do Not Decrease Fistula Rates Cristina R. Ferrone*, Andrew L. Warshaw, J. Ruben Rodriguez, Sarah P. Thayer, Carlos Fernandez-del Castillo

11:45 #1023

Reoperation for Recurrent Pain Following Failed Primary Operation in Chronic Pancreatitis Jeffrey S. Browne, Nicholas J. Zyromski, Harish Lavu, Marshall S. Baker, James A. Madura, Thomas J. Howard*

SSAT Video Session 10:30 AM - 12:00 PM

27B San Diego Convention Center

Chairs: Brian J. Dunkin, Nathaniel J. Soper SSAT VIDEO SESSION III: NOTES: WHERE ARE WE TODAY? 10:30 #1024

NOTES: Dissection of the Critical View of Safety During Transcolonic Cholecystectomy Edward Auyang*, Khashayar Vaziri, Eric S. Hungness, John A. Martin, Nathaniel J. Soper

10:48 #1025

Single Port Access (SPA) Cholecystectomy Paul G. Curcillo, Erica R. Podolsky*, Steven J. Rottman

11:06 #1026

Single Incision Laparoscopic Cholecystectomy Using Flexible Endosocopy Glenn Forrester*, John N. Afthinos, Eugenius J. Harvey, Steven Binenbaum, Grace J. Kim, Julio Teixeira

11:24 #1027

NOTES-Assisted Roux-en-Y Gastric Bypass Monika E. Hagen*, Francois Pugin, Oliver J. Wagner, Paul Swain, Nicolas C. Buchs, Priya A. Jamidar, Margherita Cadeddu, Jean Fasel, Philippe Morel

11:42 #1028

Reverse NOTES: Transgastric ERCP Yoav Mintz, Santiago Horgan, Thomas J. Savides, John Cullen*, Bryan J. Sandler, Garth R. Jacobsen, Mark A. Talamini

ASGE Interactive Education 12:00 PM - 2:00 PM

Chairs: Norio Fukami, Irving Waxman ENDOSCOPIC MUCOSAL RESECTIONS AND BEYOND (IE04) 12:00 Sp824

Endoscopic Mucosal Resections and Beyond Sharmila Anandasabapathy, Haruhiro Inoue, Andrew S. Ross, Chang Beom Ryu, Stefan Seewald, Vanessa M. Shami, Kenneth K. Wang, Naohisa Yahagi

SSAT Conference/Debate/Panel/Symposium 12:00 PM - 3:00 PM 25 San Diego Convention Center Chairs: David W. McFadden, Mark A. Talamini Sponsored by: SAGES

SSAT/SAGES JOINT SYMPOSIUM: THE GASTROINTESTINAL ANASTOMOSIS: EVIDENCE VS. TRADITION THE ESOPHAGEAL ANASTOMOSIS 12:00 Sp825

Traditional Methods to Prevent Leak Daniel Raymond

12:10 Sp826

How Improving Blood Supply Affects Leak Rate Kevin M. Reavis

12:20

Question & Answer THE PANCREATIC ANASTOMOSIS: THE DANGER OF A LEAK

12:35 Sp827

Which Anastomotic Technique Is Better? David B. Adams

12:45 Sp828

Stents, Glue, Etc.: Is Anything Proven to Help Prevent Leaks/Fistulae? Richard D. Schulick

12:55 Sp829

Defining, Controlling, and Treating a Fistula David M. Mahvi

1:05

Question & Answer

1:20

Break THE COLON ANASTOMOSIS: DIVERSION OR PRIMARY ANASTOMOSIS

1:30 Sp830

Diverting Ostomy with Pouch Procedure: Should Be Done to Prevent Severe Morbidity Charles M. Friel

1:40 Sp831

Diverting Ostomy with Pouch Procedure: Causes More Morbidity Than It Prevents Mark J. Koruda

1:50 Sp832

Colonic Trauma: Indications for Diversion vs. Repair Joseph DuBose

2:00

P-130

Marina Ballroom, Salon G Marriott Hotel & Marina

Question & Answer

ORAL SESSIONS—SCIENTIFIC SESSIONS THE BARIATRIC GASTROJEJUNOSTOMY: WHEN THINGS GO WRONG 2:15 Sp833

Dilating the Stenotic Gastrojejunostomy After Gastric Bypass Raul J. Rosenthal

2:25 Sp834

Leak: Reoperate, Drain, and Feed Distally Eric J. DeMaria

2:35 Sp835

Leak: Treat with Endoscopic Stent Tba Tba

2:45

Question & Answer

SSAT Quick Shots 12:30 PM - 1:30 PM

24ABC San Diego Convention Center

Chairs: Timothy M. Pawlik, Magesh Sundaram SSAT QUICK SHOTS III Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 12:30 #1029

Outcome of Esophagectomy Based On Surgical Subspecialty Training Brian R. Smith*, Marcelo W. Hinojosa, Kevin M. Reavis, Ninh T. Nguyen

12:36 #1030

Optimizing Outcome Measurement in Pancreatic Surgery: Can NSQIP Measure Up? Craig P. Fischer*, Thomas A. Aloia, Bridget N. Fahy, Stephen L. Jones, Barbara L. Bass

12:42 #1031

The Learning Curve of Laparoscopic Rectal Resection for Cancer: A Single-Center Experience Marco Montorsi*, Matteo Rottoli, Stefano Bona, Paolo P. Bianchi, Riccardo Rosati

12:48 #1032

Short-Term Outcomes After Laparoscopic-Assisted Compared to Open Colectomy for Cancer Karl Y. Bilimoria*, David J. Bentrem, Heidi Nelson, Steven J. Stryker, Clifford Y. Ko, Nathaniel J. Soper

12:54 #1033

Patient Demographics and Surgeon Volume in Pancreatic Resection Mortality Robert W. Eppsteiner*, Nicholas Csikesz, Jennifer F. Tseng, Shimul A. Shah

1:24 #1038

DDW Meet-the-Investigator Luncheons 12:30 PM - 1:45 PM

Participants will be able to: • Identify new scientific and clinical information relevant to digestive diseases; • Engage in scholarly and dynamic discussions of specific clinical topics; and • Engage in scholarly and dynamic discussions of specific investigative topics. Sp836

Sp837

Sp838

DDW Meet-the-Professor Luncheons 12:30 PM - 1:45 PM

Participants will be able to: • Identify new scientific and clinical information relevant to digestive diseases; • Engage in scholarly and dynamic discussions of specific clinical topics; and • Engage in scholarly and dynamic discussions of specific investigative topics. Sp839

Ablation of Barrett's Esophagus (M63) Sponsored by the ASGE ETED SIG Amitabh Chak, John A. Dumot

30A San Diego Convention Center

Sp840

Acid Reflux - Beyond the Esophagus (M82) Michael F. Vaezi

Annie A Manchester Hyatt

1:06 #1035

Meta-Analysis of Mechanical Bowel Preparation for Elective Colon and Rectal Resection Carlos E. Pineda*, Andrew A. Shelton, Tina HernandezBoussard, John M. Morton, Mark L. Welton

Sp842

Prognostic Factors Associated with Survival Following Hepatic Resection of Early-Stage Hepatocellular Carcinoma Hari Nathan*, Michael Choti, Richard D. Schulick, Timothy M. Pawlik

How to Study the Role of the Microflora in the Pathophysiology of Functional Gastrointestinal Disorders (M59) Greenroom (South Tower) Stephen M. Collins

Marriott Hotel & Marina

Sp841

1:18 #1037

Genetics of Colon Cancer (M58) Del Mar (South Tower) John M. Carethers

Marriott Hotel & Marina

Are Seasoned Surgeons Still Safe in a Laparoscopic Surgical Crisis? Kinga A. Powers*, Scott Rehrig, Noel Irias, Mark P. Callery, Steven D. Schwaitzberg, Daniel B. Jones

Sequential Resections of Liver- and Pulmonary Metastases of Colorectal Cancers: Results of 45 Patients Hannes Neeff*, Frank Makowiec, Eva Fischer, Ulrich T. Hopt, Bernward Passlick

Cell Biology of Pancreatitis (M60) Fred S. Gorelick Newport Beach (South Tower)

Marriott Hotel & Marina

1:00 #1034

1:12 #1036

Staging Error Does Not Explain the Relationship Between the Number of Nodes in a Colon Cancer Specimen and Survival Jesse Moore*, Neil H. Hyman, Peter Callas, Benjamin Littenberg

Autoimmune - Cholestatic Overlap Syndromes (M81) Mark Gordon Swain, Andrew L. Mason

Pacific (South Tower) Marriott Hotel & Marina Colonoscopy: Training and Technology (M65) Jonathan Cohen, Kai Matthes

30C San Diego Convention Center

Sp843

Diagnosis and Management of Hemochromatosis (M71) Oceanside (South Tower) Kris V. Kowdley

Marriott Hotel & Marina Sp844

Endoscopic Mucosal Resection (M79) Thomas J. Savides

31A San Diego Convention Center

P-131

W E D N E S D A Y MAY 21

W E D N E S D A Y

ORAL SESSIONS—SCIENTIFIC SESSIONS Sp845

EUS Cases (M67) Sponsored by the ASGE EUS SIG Douglas O. Faigel, Michael K. Sanders

30D San Diego Convention Center

Sp846

Sp847

MAY 21

Management of Gastroparesis (M74) Henry P. Parkman

Ford B Manchester Hyatt

Management of Post-Transplant Hepatitis C (M83) Balboa (South Tower) Nizar N. Zein

Marriott Hotel & Marina Sp848

Mucosal Ablation Techniques (M64) Ram Chuttani

30B San Diego Convention Center

Sp849

NOTES (M75) Sponsored by the ASGE Invention and Innovations SIG Pankaj J. Pasricha, Sergey V. Kantsevoy 30E

AGA Institute Problem-Based Learning Luncheons 12:30 PM - 1:45 PM

Participants will be able to: • Interact in a small group setting to define facts, develop hypotheses, and determine a learning agenda; • Increase participant's current knowledge of interesting gastrointestinal disease and issues; and • Evaluate this method of teaching with respect to achieving the session's objectives. Sp862

Manchester Hyatt Sp863

San Diego Convention Center Sp850

Novel Cancer Screening Modalities (M62) Nadir Arber, Jaroslaw Regula

Madeline B Manchester Hyatt

Sp851

Sp852

NSAIDs and the Gut (M61) Neena S. Abraham

Manchester Hyatt Sp853

Optimizing the Use of Biologics in IBD (M78) Emma C Bruce E. Sands

Manchester Hyatt Sp854

Sp855

Pediatric IBD (M66) Marla C. Dubinsky, Ajay Gulati

Madeline C Manchester Hyatt

Pediatric Liver Diseases (M73) Saul Karpen

Warner Center Marriott Hotel & Marina

Sp856

PPI Adverse Effects: Are They Real? (M76) Joseph R. Pisegna

Ford C Manchester Hyatt

Sp857

Sp858

Provider Contracts (M72) Glenn D. Littenberg

Carlsbad (South Tower) Marriott Hotel & Marina

Running An Efficient Outpatient Endoscopy Unit (M77) Joseph J. Vicari Emma B

Manchester Hyatt Sp859

Small Bowel Transplantation: When to Make the Referral (M69) Jonathan P. Fryer Madeline D

Manchester Hyatt Sp860

The Difficult Cholecystectomy (M80) Lygia Stewart

26B San Diego Convention Center

Sp861

Total Mesorectal Excision (M68) James W. Fleshman

26A San Diego Convention Center

P-132

Cystic Neoplasms of the Pancreas: Diagnosis and Management (LL12) Edward B David R. Lichtenstein

Manchester Hyatt Sp864

Madeline A Manchester Hyatt

Nutritional Complications of Bariatric Surgery (M70) Jeanette N. Keith, Roopa Vemulapalli Ford A

Clinical Trials in Private Practice 101 (LL11) Edward A Colleen M. Schmitt

When “the Going” Gets Tough: What's New in the Management of Chronic Constipation? A 33 Year Old Woman with Constipation, Straining, and Incomplete Evacuation (LL13) Edward C Suzanne Rose

Manchester Hyatt AGA Institute State-of-the-Art-Lecture 2:15 PM - 3:15 PM 6F San Diego Convention Center Chairs: Stephen J. O'Keefe, Xavier Llor Sponsored by: Nutrition & Obesity; Gastrointestinal Oncology; Intestinal Disorders

NUTRITIONAL REGULATION OF EPIGENETICS IN COLON CANCER Participants will be able to: • Discuss aspects of nutritional regulation of epigenetics to colon cancer. 2:15 Sp865

Nutritional Regulation of Epigenetics in Colon Cancer Young-In J. Kim

DDW Combined Clinical Symposium 2:15 PM - 3:45 PM 20A San Diego Convention Center Chairs: Stephen B. Hanauer, Scott A. Strong Sponsored by: AGA Institute; SSAT

BALANCING THE USE OF BIOLOGICS AND SURGERY IN MANAGEMENT OF ULCERATIVE COLITIS Participants will be able to: • Review the benefits of biological therapy in severe UC; • Review the risks of biological therapy in severe UC; • Review the benefits of surgery in severe UC; and • Review the risks of surgery for severe UC. 2:15 Sp866

Benefits of Biological Therapy in Severe UC Russell D. Cohen

2:33 Sp867

Benefits of Surgery in Severe UC David W. Larson

2:51 Sp868

Risks of Biological Therapy in Severe UC Walter Koltun

ORAL SESSIONS—SCIENTIFIC SESSIONS 3:08 Sp869 3:25

Risks of Surgery in Severe UC Asher Kornbluth Panel Discussion: Balancing the Risks of Biological and Surgical Therapy in Severe UC

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM 5 San Diego Convention Center Chairs: Girish Mishra, Syed A. Ahmad Sponsored by: Clinical Practice; Pancreatic Disorders; Liver & Biliary

CONTROVERSIES IN THE MANAGEMENT OF PANCREATICOBILIARY DISORDERS Participants will be able to: • Review the data regarding gallbladder polyps and when to intervene; • State the respective roles of ERCP and surgery for choledochal cysts; and • Acknowledge the uncertainty surrounding management of pancreatic cysts and consider the evidence supporting competing approaches. 2:15 Sp870

Gallbladder Polyps: When to Cut Out, When to Cut Bait Kevin E. Behrns

2:38 Sp871

Choledochal Cysts: The Role of Surgery Versus ERCP Richard S. Kwon

3:01 Sp872

Sphincter of Oddi and Gall Bladder Dysfunction: Reality or Myth? Charles M. Wilcox

3:23 Sp873

Pancreatic Cysts: Innocent Bystander or Harbinger of Malignancy Girish Mishra

AGA Institute Research Forum 2:15 PM - 3:45 PM

Chairs: Athos Bousvaros, Darrell S. Pardi Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IMIBD ISSUES IN IBD III. Participants will be able to: • Become familiar with the effect of natalizumab on the rate of hospitalization in patients with Crohn's disease; • Become familiar with the long term outcome of cyclosporine therapy for severe steroid refractory ulcerative colitis; and • Become familiar with the long term outcome of steroid therapy for IBD. 2:15 #1039

Natalizumab Reduces the Hospitalization Rate in Moderate to Severe Crohn's Disease Patients: A Pooled Analysis of the ENACT-1 and ENCORE Studies Bruce E. Sands*, Corey A. Siegel, Mike Spencer, Steven Hass

2:30 #1040

Have the Phenotype and the Need for Colectomy in Paediatric Ulcerative Colitis Patients Changed Over the Last 44 Years? - a Population Based Dccd, Danish Crohn Colitis Database Study Christian Jakobsen*, Anders Paerregaard, Pia S. Munkholm, Vibeke Wewer

2:45 #1041

Intravenous Cyclosporin in Severe Steroid-Refractory Ulcerative Colitis: Long-Term Follow-Up Shamita B. Shah*, Nimisha K. Parekh, Stephen B. Hanauer, Russell D. Cohen

3:00 #1042

Do Preoperative Factors Predict the Subsequent Diagnosis of Crohn's Disease in Patients with Ulcerative and Indeterminate Colitis Undergoing Ileal Pouch-Anal Anastomosis? Genevieve B. Melton*, Victor W. Fazio, Pokala R. Kiran, Mary P. Bronner, Jin He, Ian Lavery, Bo Shen, John R. Goldblum, Jean-Paul Achkar, Feza H. Remzi

3:15 #1043

The Efficacy of Corticosteroid Therapy: Analysis of 10Year Inflammatory Bowel Disease Inception Cohort (1998-2007) Gwo-Tzer Ho*, Murray Hudson, Huey Miin Lee, Winn Hui Han, Terence Ting, Priscilla P. Chiam, Hazel E. Drummond, Alan G. Shand, Ian D. Arnott, Ian D. Penman, Kelvin R. Palmer, Jack Satsangi

3:30 #1044

Costs of Treatment of Crohn's Disease and Ulcerative Colitis in U.S. Children and Adults Michael D. Kappelman*, Sheryl Rifas-Shiman, Carol Q. Porter, Daniel A. Ollendorf, Robert Sandler, Jonathan A. Finkelstein

AGA Institute Research Symposium 2:15 PM - 3:45 PM 2 San Diego Convention Center Chairs: James R. Goldenring, Andrea Todisco Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors; Immunology, Microbiology & Inflammatory Bowel Disease; Intestinal Disorders; Esophageal, Gastric & Duodenal Disorders

NEW MOLECULES DETERMINING EPITHELIAL CELL POLARITY: VIEW FROM THE EDGE Participants will be able to: • Participants will learn about intracellular and extracellular mechanisms regulating epithelial cell polarity; • Discuss the role of epithelial barrier disruption in the pathogenesis of IBD; and • Learn about new aspects in Wnt signaling pathways in epithelial cells. 2:15 Sp874

Regulation of Epithelial Tight Junctions and Inflammatory Bowel Disease Asma Nusrat

2:45 Sp875

New Molecules in Epithelial Cell Polarity James Nelson

3:15 Sp876

Wnt in Epithelial Cell Polarity Robert J. Coffey

6A San Diego Convention Center

P-133

W E D N E S D A Y MAY 21

W E D N E S D A Y MAY 21

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 2:15 PM - 3:45 PM

24ABC San Diego Convention Center

AGA Institute Research Forum 2:15 PM - 3:45 PM

29 San Diego Convention Center

Chairs: Takanori Kanai, Pawel R. Kiela

Chairs: Pankaj Pasricha, Martin Storr

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease; Intestinal Disorders

Sponsored by: Neurogastroenterology and Motility

MECHANISMS, CONSEQUENCES AND PRECLINICAL TREATMENT OF INTESTINAL INFLAMMATION Participants will be able to: • Understand how bacterial infection induces colitis through a MyD 88 independent pathway; • Understand the role of FcRn in epithelial transport; and • Understand how carbon monoxide can decrease experimental colitis. 2:15 #1045

Campylobacter jejuni Induces Rapid and Severe Colitis in Gnotobiotic IL-10-/- Mice Through a MyD88 Independent Pathway Elisabeth Lippert*, Thomas Karrasch, Young-Eun Joo, Brigitte Allard, Hans H. Herfarth, Deborah Threadgill, Christian Jobin

2:30 #1046

2:45 #1047

3:00 #1048

3:15 #1049

3:30 #1050

P-134

PHARMACOTHERAPEUTICS OF FUNCTIONAL GI AND MOTILITY DISORDERS Participants will be able to: • Learn about the effectiveness of new pharmacological therapies of functional GI disorders; • Learn about the possible role of the intestinal microflora in IBS symptoms; and • Learn about effects of novel treatments on biological readouts in functional disorders. 2:15 #1051

Anti-Flagellin Specific IgG Is Pathogenic in Colitis Through FcRn-Regulated Antigen Presentation Pathways Kanna Kobayashi*, Shuo-Wang Qiao, Timothy Kuo, Eric J. de Muinck, Kohzoh Imai, Yasuhisa Shinomura, Masaru Yoshida, Wayne I. Lencer, Richard S. Blumberg

A Phase III, 6-Month, Double-Blind, Placebo-Controlled, Randomized Withdrawal Trial of the Selective CCK-1 Antagonist Dexloxiglumide in Constipation-Predominant IBS: The Darwin Study Peter J. Whorwell*, Fabio Pace, Massimo D'Amato, Giampaolo Giacovelli, Jan Dzieniszewski, Rémy Meier, Theo Scholten, Lucio C. Rovati, Christoph Beglinger

2:30 #1052

N-Glycan Moieties in FcRn Determines Steady-State Membrane Distribution and Directional Trafficking But Not Cross-Species IgG Binding Timothy Kuo*, Eric J. de Muinck, Steven M. Claypool, Masaru Yoshida, Takashi Nagaishi, Wayne I. Lencer, Richard S. Blumberg

Randomized Double-Blind Placebo-Controlled Trial to Evaluate Efficacy and Safety of Prucalopride (Resolor®) in Elderly Patients with Chronic Constipation Stefan A. Mueller-Lissner*, An Rykx, Rene Kerstens, Lieve Vandeplassche

2:45 #1053

A Novel Acetylcholine Esterase Inhibitor Acotiamide Hydrochloride (YM443) in Functional Dyspepsia: Efficacy in a Randomized, Double-Blind, PlaceboControlled Dose Ranging Trial Nicholas J. Talley*, Jan F. Tack, Donna L. Kowalski, Mary Ann Borton, Abhijit Barve

3:00 #1054

Paroxetin, a Selective 5-Hydroxytryptamine RE-Uptake Inhibitor, Increases Postprandial Gastric Volumes and Decreases Symptoms in Patients with Postprandial Distress Syndrome (PDS) Functional Dyspepsia (FD) Ivo R. van der Voort*, Marco Schmidtmann, Peter Kobelt, Bertram Wiedenmann, Hubert Monnikes

3:15 #1055

Tegaserod (TEG) Reduces Brain Responses to Rectal Distension in IBS-C Patients: A Functional Magnetic Resonance Imaging (fMRI) Study Lisa Kilpatrick*, Steven M. Berman, Jennifer S. Labus, Brandall Y. Suyenobu, Jean Stains, Gareth A. Hicks, Bruce D. Naliboff, Emeran A. Mayer

3:30 #1056

Altered Profiles of Intestinal Microbiota and Organic Acid May Be Origin of Symptoms in Irritable Bowel Syndrome Chie Tana*, Yoshinori Umesaki, Akemi Imaoka, Tomomi Handa, Motoyori Kanazawa, Shin Fukudo

Interaction of Bacterial Antigen and FC Gamma Receptor On Mast Cell Induces Inflammation in the Intestine, a Novel Mechanism of IBD Bai-Sui Feng, Ping-Chang Yang* Enema of Carbon Monoxide (CO)-Saturated Solution Ameliorates Trinitrobenzene Sulfonic Acid-Induced Colitis in Rats Tomohisa Takagi*, Yuji Naito, Toshimitsu Okuda, Kazuhiko Uchiyama, Tetsuya Okayama, Ikuhiro Hirata, Tatsushi Omatsu, Takahiro Suzuki, Satoko Adachi, Hisato Tsuboi, Katsura Mizushima, Hitomi Okada, Osamu Handa, Satoshi Kokura, Hiroshi Ichikawa, Toshikazu Yoshikawa Increased Expression of Muts Homologue 2 (MSH2) in Crohn Disease Intestinal Strictures Is Linked to Increased Proliferative Capacity of Muscularis Mucosa Myofibroblasts Martin Floer*, David G. Binion, Vicky M. Nelson, Sharon Manley, Michael Wellner, Saba N. Sadeghi, Chloe I. Sewell, Mary F. Otterson, Torsten Kucharzik, Parvaneh Rafiee

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 2:15 PM - 3:45 PM

26B San Diego Convention Center

2:51 #1066

Endoscopic Drainage of Pancreatic Fluid Collections with Fully Covered Metallic Stents (CSEMS). How Does It Compare to Conventional Drainage with Plastic Stents? Jayant P. Talreja, Vanessa M. Shami, Jennifer Ku, Kristi Ellen, Michel Kahaleh*

3:03 #1067

Frequency of Sphincter of Oddi Dysfunction in Patients with Previously Normal Sphincter of Oddi Manometry Studies Mouen Khashab*, Evan L. Fogel, Stuart Sherman, James L. Watkins, Lee McHenry, Pradermchai Kongkam, Furqaan Ahmed, Laura Lazzell-Pannell, Suzette E. Schmidt, Glen A. Lehman

Chairs: Peter Fitzgerald, G. Nicholas Verne Sponsored by: Neurogastroenterology and Motility; Hormones, Transmitters, Growth Factors, & Their Receptors

INTERACTIONS BETWEEN GUT AND CNS Participants will be able to: • Understand the interactions between the gut and CNS. 2:15 #1057

Depression Reactivates Inflammatory Bowel Disease in Mice Jean-Eric Ghia*, Patricia Blennerhassett, Stephen M. Collins

3:15 #1068

2:30 #1058

Tryptophan Catabolism in Irritable Bowel Syndrome: Relationship to Cytokines, Severity and Psychiatric CoMorbidity Peter Fitzgerald*, Gerard Clarke, Paul Scully, John F. Cryan, Fergus Shanahan, Eamonn M. Quigley, Eugene Cassidy, Timothy G. Dinan

Prophylactic Somatostatin for Prevention of Post-ERCP Pancreatitis: A Meta-Analysis Abhishek Choudhary*, Matthew L. Bechtold, Srinivas R. Puli, Mohamed O. Othman, Wilson P. Pais, Mainor R. Antillon, Praveen K. Roy

3:27 Sp877

State-of-the-Art Lecture: Tbd John A. Martin

2:45 #1059

Differences in Localization of TRPV1 Channels and Contractile Effect of Capsaicin in Mouse Isolated Lower Gastrointestinal Tract: Higher Abundance and Sensitivity of TRPV1 Channels in Rectum and Distal Colon Than in Transverse and Proximal Colon Kenjiro Matsumoto*, Kimihito Tashima, Syunji Horie

3:00 #1060

The Effect of Acute Tryptophan Depletion (ATD) On the Activity and Connectivity of An Emotional Arousal Network During Visceral Pain Jennifer S. Labus*, Emeran A. Mayer, Tessa Kilkens, Elisabeth A. Evers, Robert-Jan Brummer, Walter H. Backes, Michiel A. van Nieuwenhoven

3:15 #1061

Spinal NMDA NR-1 Expression Following Resolution of TNBS Colitis QiQi Zhou*, Donald Price, Robert Caudle, G Nicholas Verne

3:30 #1062

RET Activation Drives Neuronal Phenotype in CNSDerived Neural Stem Cells Maria-Adelaide Micci*, Kristen M. Kahrig, Pankaj J. Pasricha

ASGE Topic Forum 2:15 PM - 3:45 PM

3 San Diego Convention Center

ASGE Topic Forum 2:15 PM - 3:45 PM

Chairs: V. Raman Muthusamy, Nuzhat A. Ahmad INTERVENTIONAL ENDOSCOPIC ULTRASOUND 2:15 #1069

EUS Guided Alcohol Ablation of Adrenal Metastasis from Non-Small Cell Lung Cancer-An Interim Analysis of a Prospective Multicenter Trial Everson Artifon*, Atul Kumar, Manoop S. Bhutani, Bhawna Halwan, Sergio E. Matuguma, Vitor N. Arantes, Paulo Sakai

2:27 #1070

Multi-Center, Feasibility Study On the Use of An EUS Delivered P32-Labeled Liquid Based Brachytherapy Implant in Advanced Pancreatic Cancer John Meenan*, Steven Mesenas, Brinder Mahon, Pierce K. Chow, Kian Fong Foo, Anthony Goh, Sarah J. Heatley

2:39 #1071

Endoscopic Choledocho-Duodenostomy (ECD) for the Treatment of Biliary Obstruction Using Prototype Compression Coil and Interventional Endosonography (EUS): A “Proof of Principle” Canine Study Kenneth J. Chang

2:51 #1072

The Safety and Feasibility of Endoscopic Ultrasound Guided Fine Needle Injection (EUS-FNI) of Local Biologic Anti-Tumor Agents (BAA) in Patients with Advanced Pancreatic Carcinoma (APC) V. Raman Muthusamy*, Reiko Ashida, John G. Lee, Kenneth J. Chang

3:03 #1073

Prospective Randomized Trial Comparing Endoscopic Ultrasound (EUS) and Gastroscopy (EGD) for TransMural Drainage of Pancreatic Pseudocysts Shyam Varadarajulu*, John D. Christein, Ashutosh Tamhane, Ernesto R. Drelichman, Charles M. Wilcox

3:15 #1074

Experimental Study Evaluating EUS-Guided RFA Using a Prototype Retractable Needle Electrode Array Shyam Varadarajulu*, Nirag Jhala, Ernesto R. Drelichman

3:27 Sp878

State-of-the-Art Lecture: New Frontiers in Therapeutic EUS Kenneth J. Chang

Chairs: John A. Martin, Evan L. Fogel ERCP-PANCREAS 2:15 #1063

Prospective Evaluation of Adverse Reactions to IodineContaining Contrast Media (CM) After ERCP Peter Draganov*, Jen-Jung Pan, Chris Forsmark

2:27 #1064

In Vivo Imaging of the Biliary (BD) and Pancreatic Duct (PD) with Optical Coherence Tomography (OCT) During ERCP Accurately Identifies Dysplastic Cellular Changes Gerard Isenberg*, Michael J. Pollack, Ashley L. Faulx, Amitabh Chak, Richard C. Wong, Farees T. Farooq, Xin Qi, Zhilin Hu, Andrew M. Rollins

2:39 #1065

Peroral Pancreatoscopy (PP) for Pancreatic Stone Therapy and Investigation of Susptected Pancreatic Lesions - First Human Experience Using the SPYGLASS Direct Visualization System (SDVS) Yang K. Chen*, Paul R. Tarnasky, Isaac Raijman, Douglas Pleskow, Raj J. Shah, Evelina L. Fortajada, Richard A. Kozarek

1 San Diego Convention Center

P-135

W E D N E S D A Y MAY 21

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION POSTGRADUATE COURSE/SPECIAL SESSION ASGE Postgraduate Course 7:30 AM - 10:45 AM

20BCD San Diego Convention Center

Chairs: Michelle A. Anderson, Michael L. Kochman, Uri Ladabaum ENDOSCOPIC PRACTICE 2008: AT THE INTERFACE OF EVIDENCE AND EXPERT OPINION - DAY 2

T H U R S D A Y MAY 22

Participants will be able to: • Identify current and emerging technologies in endoscopy and apply this knowledge to achieve desired results and minimize complications; characterize current controversies in screening for GI neoplasia, and help patients make informed decisions about screening and surveillance; • Define key issues related to upper gastrointestinal, biliary and colonic endoprosthetics, and utilize these devices more effectively in clinical practice; describe how respected experts combine established data with experience in the approach to common clinical problems, and integrate these strategies into their own practice as applicable; and • Differentiate models of sedation for endoscopy, and apply the models appropriate to individual practice settings; and discuss current trends in quality assurance, training and legal issues affecting endoscopic practice. 7:30 Sp879

Introduction Michelle A. Anderson, Michael L. Kochman, Uri Ladabaum

7:40 Sp880

Keynote Lecture: What Tools Do I Need to Be the Best? David J. Bjorkman

Chair: Douglas O. Faigel

10:10 Sp887

Legal Issues for the Gastroenterologist Peter Hoffman

10:25

Questions/Audience Response

10:35

Break

ASGE Postgraduate Course Breakout Sessions 10:45 AM - 11:45 AM

Sp888

31BC San Diego Convention Center

Sp889

Audience Response

8:05 Sp881

Understanding Moderate Sedation Lawrence B. Cohen

8:20 Sp882

Models for the Use of Deep Sedation Douglas K. Rex

8:35 Sp883

Monitoring and Patient Controlled Analgesia John J. Vargo

8:50

Sp890

Approach to the Difficult Bile Duct Stone David L. Carr-Locke, Anthony N. Kalloo

29CD San Diego Convention Center

Sp891

Approach to the Resistant Polyp Douglas K. Rex, Jason A. Dominitz

28ABC San Diego Convention Center

Sp892

Bariatric Surgery Complications James M. Scheiman, Janak N. Shah

30AB San Diego Convention Center

Sp893

Bleeding: When to Endoscope Elizabeth Rajan, Lawrence J. Brandt

28DE San Diego Convention Center

Sp894

Endoscopic Management of Chronic Pancreatitis Adam Slivka, Douglas G. Adler 25ABC

San Diego Convention Center Sp895

Endoscopic Management of Pancreatic Pseudocysts Todd H. Baron, Robert H. Hawes 30CD

San Diego Convention Center Sp896

EUS for Colorectal Pathology Steven A. Edmundowicz, Thomas J. Savides

32AB San Diego Convention Center

Questions/Audience Response Sp897

ASGE Postgraduate Course General Session 9:05 AM - 9:35 AM 20BCD San Diego Convention Center

EXPERTS IN THE HOT SEAT (SESSION 1) Case Topic: Acute GI Bleeding in the High-Risk Patient M. Brian Fennerty, Robert H. Hawes

Setting Up An Endoscopic Database Neena S. Abraham, David A. Lieberman

33BC San Diego Convention Center

Sp898

Success and Safety in EUS Kevin M. McGrath, Marcia I. Canto

24ABC San Diego Convention Center

Chair: Uri Ladabaum

9:05 Sp884

Approach to Occult Bleeding and Suspected Small Bowel Lesions John M. Inadomi, David E. Fleischer 29AB

San Diego Convention Center

SEDATION AND MONITORING 8:00

Access for Enteral Feeding Peter D. Siersema, Gregory G. Ginsberg

ASGE Postgraduate Course Luncheon Breakout Sessions 11:50 AM - 12:50 PM

Chair: John J. Vargo Sp899

9:35

Audience Response

9:40 Sp885

Measuring Quality in Endoscopy David J. Bjorkman

9:55 Sp886

Training in New Procedures Robert H. Hawes

P-136

Access for Enteral Feeding Peter D. Siersema, Gregory G. Ginsberg

31BC San Diego Convention Center

ACHIEVING QUALITY IN ENDOSCOPIC PRACTICE Sp900

Approach to Occult Bleeding and Suspected Small Bowel Lesions John M. Inadomi, David E. Fleischer 29AB

San Diego Convention Center

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION Sp901

Approach to the Difficult Bile Duct Stone David L. Carr-Locke, Anthony N. Kalloo

29CD San Diego Convention Center

Sp902

Approach to the Resistant Polyp Douglas K. Rex, Jason A. Dominitz

28ABC San Diego Convention Center

Sp903

Bariatric Surgery Complications James M. Scheiman, Janak N. Shah

30AB San Diego Convention Center

Sp904

Bleeding: When to Endoscope Elizabeth Rajan, Lawrence J. Brandt

28DE San Diego Convention Center

Sp905

Endoscopic Management of Chronic Pancreatitis 25ABC Adam Slivka, Douglas G. Adler

San Diego Convention Center Sp906

Endoscopic Management of Pancreatic Pseudocysts 30CD Todd H. Baron, Robert H. Hawes

San Diego Convention Center Sp907

EUS for Colorectal Pathology Steven A. Edmundowicz, Thomas J. Savides

32AB San Diego Convention Center

Sp908

Setting Up An Endoscopic Database Neena S. Abraham, David A. Lieberman

3:25 Sp916

Hemostasis Thomas J. Savides

3:40 Sp917

Endoscopic Muscosal Resection Christopher J. Gostout

3:55 Sp918

Foreign Body Management Gregory G. Ginsberg

4:10

Questions/Audience Response

Chair: Christopher J. Gostout THE FUTURE? 4:25

Audience Response

4:30 Sp919

NOTES: What Is the Future? Annette Fritscher-Ravens

4:45 Sp920

NBI, Confocal, and High-Resolution Imaging Paul Fockens

5:00 Sp921

New Technologies for Colonic Imaging James M. Scheiman

5:15 5:30 Sp922

T H U R S D A Y

Questions/Audience Response Conclusion Michelle A. Anderson, Michael L. Kochman, Uri Ladabaum

33BC San Diego Convention Center

Sp909

Success and Safety in EUS Kevin M. McGrath, Marcia I. Canto

24ABC San Diego Convention Center

ASGE Postgraduate Course General Session 12:55 PM - 5:35 PM 20BCD San Diego Convention Center Chair: David A. Lieberman SAFETY IN ENDOSCOPY 12:55

Audience Response

1:00 Sp910

Infection Control Douglas B. Nelson

1:15 Sp911

Avoiding and Managing the Poor Colon Prep Todd H. Baron

1:30 Sp912

Anticoagulation and Anti-Platelet Management Neena S. Abraham

1:45 Sp913

Minimizing ERCP Complications Anthony N. Kalloo

2:00

Questions/Audience Response

Chair: Michael L. Kochman EXPERTS IN THE HOT SEAT (SESSION 2) 2:15 Sp914 2:45

Case Topic: Barrett's Esophagus David E. Fleischer, Lawrence J. Brandt Break

Chair: David E. Fleischer THE EXPERT APPROACH TO COMMON ISSUES 3:05 3:10 Sp915

Audience Response Small Bowel Bleeding John M. Inadomi

P-137

MAY 22

POSTER SESSIONS—CLINICAL CLINICAL AASLD Poster Session 8:00 AM - 5:00 PM

S1008

The Role of the Novel IL-10-Related Cytokines IL-22, IL-26, IL-28a/B, and IL-29 in Hepatitis C Virus Infection Julia Diegelmann*, Florian Beigel, Kathrin Zitzmann, Artur Kaul, Christoph J. Auernhammer, Burkhard Göke, Ralf Bartenschlager, Helmut Diepolder, Stephan Brand

S1009

Dynamics of Liver Stiffness During Peginterferon AlphaRibavirin Treatment in Patients with Chronic Hepatitis C Christophe Hezode*, Laurent Castera, Isabelle Rosa, Dominique Roulot, Vincent Leroy, Magali Bouvier-Alias, Valerie Dhalluin-Venier, Francoise Roudot-Thoraval, Ariane Mallat, Jean-Michel Pawlotsky

S1010

Effect of Renal Function On Dose Reduction and Sustained Viral Response in Patients with Hepatitis C Treated with Pegylated Interferon and Ribavirin Ihab Hammoud*, Kimberly Ann Brown, Stuart C. Gordon, Fadi Antaki, Rodolfo Guevara, Mei Lu, Dilip Moonka

S1011

Pre-Transplant Antiviral Treatment of Hepatitis C with Decompensated Cirrhosis: A Systematic Review of Risks and Benefits Alexandra K. Retana*, John B. Wong

S1012

Viral Kinetics and Duration of Hepatitis C Therapy for Genotypes 2 and 3: A Meta-Analysis Alexandra K. Retana*, John B. Wong

S1013

Drug Users with Chronic Hepatitis C Who Are Adherent to Antiviral Treatment Will Finally Benefit from Therapy Olga Anagnostou*, Spilios Manolakopoulos, Melanie Deutsch, Elli Tiniakou, Markos Giannaris, George Papatheodoridis, Emanuel K. Manesis, Dimitrios Tzourmakliotis, Athanasios Archimandritis

S1014

The Use of Specialty Care Pharmacies for the Treatment of Hepatitis C Stanley M. Cohen*, Joseph Ahn

S1015

The “Tma Blip”: Clinical Significance of Transient Positivity of Hepatitis C Virus (HCV) TranscriptionMediated Amplification (Tma) During Periods of Polymerase Chain Reaction (PCR) Negativity On AntiViral Therapy Christopher DiGiorno*, Kathy Deng, Ana R. Casellas, Carol A. McEwan, Jody Hirsch, David C. Wolf, Edward Lebovics

S1017

Factors Associated with Premature Discontinuation of Chronic Hepatitis C Virus Treatment Using Pegylated Interferon and Ribavirin: A Four Year Experience Edward Friedman*, Lydia Aye, Francisco C. Ramirez, Richard Gerkin, Erin Tharalson, Nooman Gilani

Sails Pavilion San Diego Convention Center

HCV TREATMENT I S1000



S1001



S1002

S U N D A Y MAY 18

Results from the Epic3 Program: Platelet Counts Are Strong Predictors of Sustained Viral Response (SVR) in the RE-Treatment of Previous Interferon/Ribavirin NonResponders (Nr) Thierry Poynard*, Eugene Schiff, Ruben Terg, Ricardo Moreno-Otero, Steven L. Flamm, Warren N. Schmidt, Thomas Berg, Fernando L. Goncales, Jr, Jenny Heathcote, Moises Diago, Thomas J. McGarrity, Pierre Bedossa, Weipeng Deng, Pabak Mukhopadhyay, Louis H. Griffel, Margaret Burroughs, Clifford A. Brass, Janice Albrecht Clearance of HCV At 5 Year Follow-Up for Peginterferon Alfa-2b ± Ribavirin Is Predicted By Sustained Virologic Response At 24 Weeks Post Treatment Karen Lindsay*, Michael P. Manns, Stuart C. Gordon, Paul Pockros, Dieter Haussinger, Stephanos J. Hadziyannis, Warren N. Schmidt, Ira M. Jacobson, Rafael Barcena, Eugene Schiff, Obaid S. Shaikh, Bruce R. Bacon, Patrick Marcellin, Coleman I. Smith, John G. McHutchison, Weipeng Deng, Lisa D. Pedicone, Janice Albrecht



Amino Acid Substitutions in Core Region of Hepatitis C Virus Genotype 1b Predict Poor Response to PegylatedInterferon-Alpha 2b and Ribavirin Combination Therapy Kazuhiko Hayashi*, Yoshiaki Katano, Takashi Honda, Isao Nakano, Takashi Kumada, Hidemi Goto

S1003



Response to Therapy with Pegylated Interferon and Ribavirin in Hispanics with Hepatitis C Compared to Non-Hispanic Whites Stanley Yu*, Jeffrey Douglass, Clifford Qualls, Sanjeev Arora, Jeffrey C. Dunkelberg

S1004

Clearance of HCV in Children At 5-Year Follow-Up Is Predicted By Sustained Virologic Response At 24 Weeks Post Treatment with Interferon Alfa-2b Plus Ribavirin Deirdre Kelly*, Barbara Haber, Regino P. Gonzalez-Peralta, Karen F. Murray, Maureen M. Jonas, Jean P. Molleston, Michael R. Narkewicz, Frank R. Sinatra, Thomas Lang, Alain Lachaux, Stefan Wirth, Mark Shelton, Helen S. Te, Henry Pollack, Weipeng Deng, Stephanie Noviello

S1005

Very Early Viral Response to Treatment of Hepatitis C Virus (HCV) with Pegylated Interferon and Ribavirin: The First 24 Hours Emma J. Devitt*, John A. Browne, Caroline Walsh, John P. Crowe

S1006

Efficacy and Safety of Peginterferon Alfa-2a or -2b Plus Ribavirin in the Routine Daily Treatment of Chronic Hepatitis C Patients in Germany: The Practice Study Thomas Witthoeft*, Dietrich Hueppe, Christine John, Joerg Goelz, Ulrike Meyer, Renate Heyne, Bernd Moeller, Ralph Link, Gerlinde Teuber, Slawomir Sworszt, Andreas Herrmann, Andreas Wollschlaeger, Axel Baumgarten, KarlGeorg Simon, Joerg Cordes, Gero Moog, Nektarios Dikopoulos, Stefan Mauss

S1007

P-138

Utility of Serum Biomarker Profiles in Predicting the Treatment Outcome in Chronic Hepatitis C Virus Patients Krishna S. Kasturi*, John R. Petersen, Audrey N. Nguyen, Ned Snyder

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Clinical Practice

COLORECTAL CANCER Participants will be able to: • Evaluate recent research on colorectal cancer. S1018

Colorectal Cancer (CRC) Screening of Persons with First Degree Relatives (Fdr) with CRC in Aragon, Spain: Application of a Validated Decision Analytic Model to Inform Public Policy Uri Ladabaum*, Angel Ferrandez, Angel I. Lanas

S1019

Who Are We Missing in Colorectal Cancer Screening? George Abdelsayed, Jianmin Tian*, Beili Dong, Yan Feng

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL S1020

BMI and Advanced Colorectal Neoplasia in Average Risk Women: Results of Screening Colonoscopy in a Diverse Population Using a High Resolution Colonoscope Joseph C. Anderson*, Benjamin Stein, Ramona Rajapakse, Zvi A. Alpern

S1021

Prevalence and Predictors of Fecal Occult Blood Testing After Colonoscopy Deborah A. Fisher*, Janet Grubber, Cynthia J. Coffman, Corrine I. Voils, Sally W. Vernon, Dawn Provenzale

S1022

Prevalence of Colorectal Premalignant Lesions Detected By Colonoscopy in Different Risk Groups for Colorectar Cancer Fernando Van Domselaar, Juan A. De Paula*, Federico h. Marcaccio, Rudiger Lam Chong, Carlos Alberto Macías Gomez, Eduardo Mullen, Carlos Vaccaro, Jorge R. Dávolos

S1023

Colonoscopy Performed Outside of Hospital in Ontario: Trends, Patient and Endoscopist Factors Othman Alharbi*, Linda Rabeneck, Lawrence Paszat, Duminda N. Wijeysundera, Rinku Sutradhar, Lingsong Yun, Christopher M. Vinden, Jill M. Tinmouth

S1024

Primary Care Physician Attitudes Towards Screening Colonoscopy in Old Age. Experience from the Screening Colonoscopy in Older People (SCOPE) Study Oyekoya T. Ayonrinde*, Frank M. Sanfilippo

S1025

S1026

Pain Management During Screening Colonoscopy: Who Gets the Drugs? Roya Fathi*, Dezheng Huo, Karen E. Kim



Screening Colonoscopy for Colorectal Cancer Prevention - Results from a German Online Registry On 269,000 Cases Bernd Bokemeyer*, Axel Rambow, Dietrich Hüppe, Marc Düffelmeyer, Wolfgang Tacke, Herbert Koop

S1027



Clinical Usefulness of Glycated Hemoglobin(Hb A1c) As a Predictor of Adenomatous Polyp in Colorectum in Asymptomatic Men in Their Forties Beom Jin Kim*, Young-Ho Kim, Dong Hyun Sinn, Tae Hoon Jang, Dong Kyung Chang, Hee Jung Son, Poong-lyul Rhee, Jae J Kim, Jong Chul Rhee, Jeong Hwan Kim, Heung Up Kim, Moon Hee Yang, Yoon Ho Choi

S1028

The Relationship of Colon Cancer Identified At FollowUp Examination to the Findings At the First Colonoscopy a Thiry Year Study Harvey W. Olsen

S1029

Non-Surgical Management of Attenuated Familial Adenomatous Polyposis: Results of a Long-Term Surveillance Program Patrick M. Lynch*, Devki S. Saraiya

S1030

Colonoscopy Surveillance After Polypectomy May Be Extended to 7 Years Hannah L. Miller, Rupa Mukherjee*, Jianmin Tian, Anil B. Nagar

S1031

Endoscopic Submucosal Dissection for Colorectal Neoplasms in 196 Consecutive Cases Naoyuki Yamaguchi*, Hajime Isomoto

S1032

Favorable Factors for Survival in Elderly Patients with Colorectal Cancer Ji Min Jung*, Sung-Ae Jung, Seong-Eun Kim, Min Jung Kang, Ki-Nam Shim, Kwon Yoo, Il Hwan Moon, Gue Won Chung

S1033

Prospective Evaluation of Extended Endoscopic Mucosal Resection for Large Rectal Adenomas Frank J. van den Broek*, Paul Fockens, Evelien Dekker

S1034

Adenomatous Polyp in Colorectum May Predict the Early Atherosclerosis in Patients with Metabolic Syndrome Beom Jin Kim*, Young-Ho Kim, Dong Hyun Sinn, Yoon Jung Kim, Hoi Jin Kim, Dong Kyung Chang, Hee Jung Son, Poong-lyul Rhee, Jae J Kim, Jong Chul Rhee, Moon Hee Yang, Yoon Ho Choi, Jeong Hwan Kim, Heung Up Kim, Yeon Hyun Choi

S1035

The Colonoscopic Missing Rates of Colorectal Polyps Determined By Subsequent Polypectomy Won Moon*, Se Young Park, Seun Ja Park, Moo In Park, Kyu Jong Kim

S1036

Patient Preferences Questionnaire for Screening Colonoscopy: Same Day Consult and Procedure Liliana Oliveira*, Richmond G. Sy

S1037

Colonic Stenting for Malignant Large Bowel Obstruction: Long Term Assessment of Symptoms and Quality of Life Satish Nagula*, Nicole Ishill, Arnold J. Markowitz, Mark A. Schattner, Martin R. Weiser, Larissa Temple, Ann G. Zauber, Howard T. Thaler, Hans Gerdes

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Clinical Practice

EDUCATION AND TRAINING Participants will be able to: • Evaluate research in education and training. S1038

Should Percutaneous Liver Biopsy Remain An ACGME Requirement in GI Fellowship Training Programs? Tanaya Bhowmick*, David Lee, Hazar Michael, Tamir BenMenachem, Jennifer Mako

S1039

Teaching the Competencies: Educational Performance Improvement Using OSCEs for Gastroenterology Fellows Bani Chander*, Robert Kule, Peter J. Baiocco, Sita S. Chokhavatia, Donald P. Kotler, Michael Poles, Sondra Zabar, Elizabeth H. Weinshel

S1040

Comparison of Endoscopic Hemostasis Management Preferences for Nonvariceal GI Hemorrhage Among Trainees & Faculty Members Douglas H. Weinstein*, L. S. Hynan, Sun-Young Lee, Shou Jiang Tang, Jayaprakash Sreenarasimhaiah, Luis F. Lara, Don C. Rockey

S1041

Overuse of Stress Ulcer Prophylaxis in the Critical Care Setting and Beyond Christopher P. Farrell*, Giancarlo Mercogliano, James J. Thornton, Catherine L. Kuntz

S1042

Gastroenterologist' Knowledge and Perception in Dealing with Irritable Bowel Syndrome Patients Ying-cong Yu*, Ning Dai, Yuan Jiang, Tian-hua Ren, Shu-jie Chen

Denotes DDW Poster of Distinction

P-139

S U N D A Y MAY 18

POSTER SESSIONS—CLINICAL AGA Institute Poster Session 8:00 AM - 5:00 PM

S1055

Inappropriate Proton Pump Inhibitor (PPI) Use in the Acute Hospital Setting Can Be Reduced Philip R. Cassar, Jessica L. Widmer*, James H. Grendell

S1056

Medical Management of Inflammatory Bowel Disease; Patterns of Infliximab Use Amongst Canadian Gastroenterologists Jennifer Jones*, Remo Panaccione, Margaret Russell, Robert J. Hilsden

S1057

How Thoroughly Is Diarrhoea Investigated in Secondary Care? Asma Fikree*, Toyah Singh, Raymond D'Souza, Niall van Someren, Kalpesh Besherdas

S1058

Hepatitis A and B Immunization Practices Among Community Physicians of Chronic Hepatitis C Patients Yasmin Metz*, Ketan Kulkarni, Maya Gambarin-Gelwan, Ira M. Jacobson

Sails Pavilion San Diego Convention Center

Sponsored by: Clinical Practice

HEALTHCARE DISPARITIES AND HEALTHCARE UTILIZATION Participants will be able to: • Review recent research in healthcare disparities and healthcare utilization. S1043



Gender Differences in Upper Gastrointestinal Symptom Presentation Martijn G. van Oijen*, Lieke A. van Kerkhoven, Robert Laheij, Adriaan C. Tan, Jan B. Jansen

S1044

Awareness of Gastroesophageal Reflux Disease in Hispanic Adults: A Survey in 5 US Cities Marta Illueca*, Joseph A. Crawley

S1059

Gastric Cancer in African-Americans, Trend in 50 Years Experience of An Inner City Medical Center Hassan Ashktorab*, Fatemeh Hosseinkhah, Seyed Mehdi Nouraie, Edward L. Lee, Duane T. Smoot

Intravenous PPI Ordering Pattern in a Computerized Physician Order Entry System: Factors Affecting Inappropriate Usage Augustin Nguyen*, Flavio Habal

S1060

Gender-Related Differences in Quality of Life Perception in Inflammatory Bowel Disease Zuzana Zelinkova*, Judith E. Baars, Tineke Markus, E. J. Kuipers, Christien J. van der Woude

S1045

S1046

S U N D A Y MAY 18

S1047

Colorectal Cancer Trend in African-American in 50 Years, Hospital Based Study, a Shift Toward More Advanced Tumor Fatemeh Hosseinkhah*, Seyed Mehdi Nouraie, Edward L. Lee, Duane T. Smoot, Hassan Ashktorab



Screening for Colorectal Carcinoma in Lagos, NigeriaAre We Doing It Right? - a Preliminary Report Charles A. Onyekwere*, Anthonia O. Ogbera

S1048

Awareness of Colorectal Cancer Screening in Population of Downtown Brooklyn Sushil Duddempudi*, Vishal Ghevariya, Malvinder Singh, Sury Anand

S1049



Socioeconomic Disparities in Patients with Metastatic Gastrointestinal Stromal Tumors: Imatinib and the Shift Toward Equality Avo Artinyan*, Joseph Kim, Perry Soriano, Smita Bhatia, Joshua Ellenhorn

S1050

The Use of Complementary and Alternative Medicine in Pediatric Patients with Functional and Organic Gastrointestinal Diseases: Results from a Multi-Center Survey Arine M. Vlieger, Marjolein Blink, Ellen Tromp, Marc A. Benninga*

S1051

Factors Predicting Difficulty Level of Colonoscopies in African-Americans: A Prospective Study At a Teaching Institution Prashant Krishnan*, Robert Dempsey, Ali Nawras

S1052

The Impact of Physician Recommendations On Colorectal Cancer Screening Compliance and Contemplation in Gynecology Patients Stacy B. Menees*, John M. Inadomi, Grace H. Elta, Sheryl Korsnes, Leslie B. Aldrich

S1053

S1054

P-140

Effectiveness of Fecal Occult Blood Testing (FOBT) in a Primary Care Clinic: Quality Improvement By Direct GI Referral for Positive Tests Erik J. Van Kleek*, Angelina Hoadley, Shanglei Liu, Lorraine Conn, Samuel B. Ho Drug Utilization Review of Acid Suppressants (DURABLE) - An Audit to Assess the Utilization of Proton Pump Inhibitors and Histamine H2-Receptor Antagonists in Canadian Hospitals Alan Barkun*, Robert A. Enns, Joseph Romagnuolo, Tanja Müller, Bruce T. Kalmin, Ian A. Hawes, Yao Lei

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

GERD: COMPLICATIONS AND EXTRAESOPHAGEAL PRESENTATIONS Participants will be able to: • Update on GERD complications and extraesophageal presentations. S1061

Does a Pre-Transplant Diagnosis of GERD Increase the Risk of Acute Rejection in Lung Transplant Recipients Christopher C. Canale*, Kristen Hilden, Fatima Gangotena, John C. Fang, Barbara Cahill, Kathryn A. Peterson

S1062



Sleep Disturbance Associated with Gastro-Oesophageal Reflux Disease (GORD): Frequency and Evolution with Treatment According to Patients Guillaume Cadiot*, Pierre-Henri Delaage, Caroline Fabry, Philippe Barthelemy

S1063

The Effect of Esomeprazole 20 Mg Twice Daily Versus Placebo On Acoustic and Perception Parameters of the Voice in Patients Diagnosed with GERD-Related Posterior Laryngitis (GPL) Tomas Navarro-Rodriguez*, Julie Barkmeier-Kraemer, Kent Wilson, Marcia R. Willis, North Noelck, Jeannette Powers, Ronnie Fass

S1064

Development of Acid Exposure, Symptoms and Laryngeal Findings in Healthy Subjects: A More Than 10-Years Follow-Up Study Riitta Ylitalo Moller*, Olle Andersson, Caterina A. Finizia, Magnus Ruth

S1065

Correlation Between Pulmonary Fibrosis and GERD in Scleroderma (SSc) Patients: Studies Using 24-Hour Ambulatory Intraluminal pH-Impedance (MII-pH) Edoardo Savarino*, Marco Bazzica, Massimo Ghio, Patrizia Zentilin, Daniel Pohl, Radu Tutuian, Vincenzo Savarino

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL S1066

Gastroesophageal Reflux and Aspiration of Gastric Contents in Adult Patients with Cystic Fibrosis Kathleen Blondeau*, Lieven Dupont, Veerle Mertens, Geert M. Verleden, Anne Malfroot, Yvan Vandenplas, Bruno Hauser, Daniel Sifrim

S1076

PPI Activity Is Optimized By VB101, a Parietal Cell Activator Yehuda Chowers*, Tal Atarot, Aleksey Kostadinov, Marina Nudelman, Osnat Bar-Peled, Leo Brenman, Olga Pankratov, Michael Naveh

S1067

Nocturnal Weakly Acidic Reflux Promotes Aspiration of Bile Acids in Lung Transplant Recipients Kathleen Blondeau*, Veerle Mertens, Bart M. Vanaudenaerde, Robin Vos, Dirk E. Van Raemdonck, Geert M. Verleden, Lieven Dupont, Daniel Sifrim

S1077

Effect of Obesity On Efficacy of Maintenance Intermittent Therapy in Patients with Symptomatic Gastroesophageal Reflux Disease (sGERD) Ronnie Fass*, Byron P. DeLemos, Jim Xiang, John LoCoco, Yijun Sun, Honglan Li, Yufang Lu

S1068

Pepsin or Bile Acids: What Is the Best Marker of Gastric Aspiration in Lung Transplant Recipients? Veerle Mertens*, Kathleen Blondeau, Bart M. Vanaudenaerde, Robin Vos, Dirk E. Van Raemdonck, Geert M. Verleden, Lieven Dupont, Daniel Sifrim

S1078

Gastric Histology in Children Treated with Proton Pump Inhibitors (PPIs) Long-Term Eric Hassall*, David A. Owen, Wendy Kerr, Theresa Sturby, Stephanie Fitzgerald, Hashem B. El-Serag

S1079

S1069

New Approach to the Treatment of Laryngopharyngeal Reflux Symptoms Using Rikkunshito (Japanese Herbal Medicine TJ-43) in Patients Who Responded Poorly to Acid Suppression Therapy Nobuhiko Oridate*, Hiroshi Takeda, Yasushi Mesuda, Noriko Nishizawa, Masahiro Asaka, Satoshi Fukuda

CYP2C19 Genotype Is a Useful Marker of Optimal Dose of a Proton Pump Inhibitor in the Maintenance Therapy of Symptomatic Gastroesophageal Reflux Diseases Takahisa Furuta*, Mitsushige Sugimoto, Chise Kodaira, Masafumi Nishino, Mihoko Yamade, Mutsuhiro Ikuma, Michio Kimura, Akira Hishida, Takashi Ishizaki

S1080

S1070

Effect of Lansoprazole On Extraesophageal Manifestations of GERD in a Rat Chronic Acid Reflux Esophagitis Model Daisuke Asaoka*, Akihito Nagahara, Yuko Izumi, Akihiko Kurosawa, Masato Kawabe, Mariko Hojo, Sumio Watanabe

Physicians Underestimate Symptom Burden and Overestimate Treatment Effects in GERD Patients Hubert Monnikes*, Holger Schmitt, Peter Berghoefer, Hubert Doerfler, Robert Heading

S1081

High-Dose Esomeprazole in Combination with Baclofen in the Treatment of Symptomatic Refractory Gastroesophageal Reflux Disease — a pH-Metry/ Impedance Controlled Study Monther Bajbouj, Valentin Becker, Roland M. Schmid, Alexander Meining*

S1071

S1072

Gastroesophageal Reflux in Idiopathic Pulmonary Fibrosis Patients Awaiting Lung Transplantation Yevgenia Pashinsky*, Maria L. Padilla, Eric S. Goldstein, Barry W. Jaffin Reflux Characteristics in Asthmatic Patients Refractory to Acid Suppression As Defined By Impedance Testing Jeremy M. Alvord*, Kristen Thomas, Wayne Samuelson, John C. Fang, Kathryn A. Peterson

AGA Institute Poster Session 8:00 AM - 5:00 PM

S1082

In Vitro and In Vivo Effects of GSK1007066A, a Selective H+/K+-ATPase Inhibitor Colin A. Campbell*, Lucy M. Mensah, Stacey L. Wood, Jill Darton, Sarah J. Hadingham, Pamela Gaskin, Emmanuel H. Demont, Mark Bamford, Kevin Lee, Peter McLean

S1083

Effects of the Long Acting Histamine 2 Receptor Antagonists, Lavoltidine, GSK1023911A and GSK1040323B, On Gastric Acid Secretion Measured By pH-Metry in Gastric Fistula Dogs Colin A. Campbell*, Pamela Gaskin, Paul J. Beswick, Kevin Lee, Peter McLean

S1084

Effects of the Gastrin Antagonist, YF476, On Gastric Acid Secretion Models Using Gastric Fistula Dogs Colin A. Campbell*, Pamela Gaskin, Julia E. Smith, Malcolm J. Boyce, James R. Black, Kevin Lee, Peter McLean

S1085

The Proportion of Patients Who Are Free of Reflux Symptoms During the Initial Days of Treatment with Proton Pump Inhibitors (PPIs) in GERD Trials: A MetaAnalysis Yuhong Yuan*, Chang Cheng Wang, Yu-Hong Yuan, Richard H. Hunt

S1086

Intragastric Acid Control in the “Acid Pocket”: A Comparator Trial of Esomeprazole, Lansoprazole, and Pantoprazole in Hispanic Adults with Symptomatic Gastroesophageal Reflux Disease (GERD) John E. Pandolfino*, Philip Katz, Jay L. Goldstein, Douglas R. Morgan, Peter N. Barker, Marta Illueca

S1087

Control of 24-Hour Gastric Acidity After Morning Dosing with Immediate-Release and Delayed-Release Proton Pump Inhibitors in Patients with GERD Symptoms Colin W. Howden*, E. David Ballard, Frauke K. Koch, Yun Hardiman, A David Mundt, Theresa C. Gautille, Robert G. Bagin

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

GERD: PHARMACOLOGICAL TREATMENT Participants will be able to: • Progress in pharmacological treatment of GERD. S1073

Tak-390MR, a Proton Pump Inhibitor (PPI) with a Novel Dual Delayed Release (DDR) Formulation, Is Highly Effective in the Healing of Erosive Esophagitis (EE): Data from Two Randomized Controlled Trials Prateek Sharma*, Nicholas J. Shaheen, Maria Claudia Perez, Betsy Pilmer, Misun Lee, David A. Peura

S1074

Tak-390MR, a Proton Pump Inhibitor with a Novel Dual Delayed Release Formulation, Maintains Healing and Controls Heartburn in GERD Patients with Healed Erosive Esophagitis David C. Metz*, Colin W. Howden, Maria Claudia Perez, Lois M. Larsen, Janet M. O'Neil

S1075

Incidence and Risk Factors for Relapse of Erosive Gastroesophageal Reflux Disease During Two Years Maintenance Treatment with Proton Pump Inhibitor: A Prospective Multicenter Study in Japan Kazuma Fujimoto*, Michio Hongo, Yasuhiro Marukawa, Toshihisa Arai, Yukinori Sakata

Denotes DDW Poster of Distinction

P-141

S U N D A Y MAY 18

POSTER SESSIONS—CLINICAL S1088

S1089

S1090

S U N D A Y

Predictors of Success and Quality of Life Assessment in Step-Down OMEPRAZOLE Therapy for GastroEsophageal Reflux Disease: A Multi-Center Prospective Clinical Trial in Japan Takao Tsuzuki*, Hiroyuki Okada, Keisuke Hori, Masahide Kita, Daisuke Tanioka, Seiji Kawano, Masafumi Inoue, Satoshi Yagi, Ryuta Takenaka, Yoshiro Kawahara, Kazuhide Yamamoto Randomized, Double-Blind, Placebo-Controlled Multicenter Study to Assess the Effect of Helicobacter pylori (HP) Eradication in Patients with GastroEsophageal Reflux Disease (GERD): The Erastrat Study Werner Schwizer, Dieter Menne, Michael Fried, Kurt Schuetze, Mark R. Fox*, the Swiss, Austrian, German Erastrat Group On behalf of Variations in Definitions of Nighttime GERD: A Systematic Review Prajesh Kothawala*, James E. McGuigan, Stephen Lange, Daniel Aguilar, Diana Morgenstern, Ning Yan, Bonnie B. Dean

S1101

Gastric Acid Suppresion of Oral Powder 20 mg OMEPRAZOLE. Pilot Study in Healthy Subjects Norberto G. Caruso, Luis O. Soifer*, Daniel Peralta

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

GERD: SURGICAL, INTRALUMINAL, AND NONPHARMACOLOGIC TREATMENT Participants will be able to: • Update in surgical, intraluminal, and non-pharmacologic treatment for GERD. S1102



Computer Simulation of Gastric Stimulation Peng Du*, Leo K. Cheng, Andrew J. Pullan

S1103

Long-Term Outcome of Nissen Fundoplication in Erosive and Non-Erosive Reflux Disease Joris A. Broeders*, Werner A. Draaisma, Albert J. Bredenoord, Durk Vries, de, André Smout, Hein G. Gooszen

S1091

Helicobacter pylori cagA Status Does Not Interfere in Erosive Esophagitis Healing Rates. A Prospective Trial Ricardo C. Barbuti*, Tomas Navarro-Rodriguez, Jaime N. Eisig, Fernando M. Silva, Schlioma Zaterka, Rejane Mattar, Decio Chinzon, Joaquim P. Moraes-Filho

S1092

Gastroesophageal Reflux Disease - a Chronic, Persistent Disease: A Systematic Review of the Literature David Armstrong

S1104



S1093

Dose-Effect of S-Tenatoprazole-Na in Healthy Volunteers: A Meta-Analysis of Individual Subject Data from Four Pharmacodynamic Studies Yuhong Yuan*, Ying Chen, Richard H. Hunt

The Learning Curve in Laparoscopic Nissen Fundoplication Revisited Joris A. Broeders*, Werner A. Draaisma, Hilda G. Rijnhart de Jong, André Smout, Jan J. van Lanschot, Hein G. Gooszen

S1105

The Pharmacokinetics of TAK-390mr 60 mg, a Dual Delayed Release Formulation of the Proton Pump Inhibitor TAK-390, and Lansoprazole 60 mg: A Retrospective Analysis Michael D. Mayer*, Majid Vakily, Galen Witt, Darcy J. Mulford

Esophageal Hypersensitivity Is Not a Contraindication for Nissen Fundoplication Joris A. Broeders*, Werner A. Draaisma, Albert J. Bredenoord, Durk Vries, de, André Smout, Hein G. Gooszen

S1106

The Relevance of Symptom Association Analysis for the Outcome After Nissen Fundoplication Joris A. Broeders*, Werner A. Draaisma, Albert J. Bredenoord, Durk Vries, de, André Smout, Hein G. Gooszen

S1107

Radiofrequency Energy Delivery in PPI-Dependent GERD Patients: Results of a Multicenter Randomized Trial Emmanuel Coron*, Guillaume Cadiot, Frank Zerbib, Philippe R. Ducrotte, Véronique Sébille, Frederick T. Ducrot, Philippe Pouderoux, Joris Arts, Marc Le Rhun, Sylvie Sacher-Huvelin, Stanislas Bruley des Varannes, Jean Paul Galmiche

S1108

Effect of Fundoplication On the Motility of the Esophagogastric Junction and Distal Esophagus Monika A. Kwiatek*, William J. Bulsiewicz, Mandana Neil, John E. Pandolfino, Peter J. Kahrilas

S1109

Use of the Functional Lumen Imaging Probe (FLIP) to Determine Structural Changes in the Region of the Esophagogastric Junction After Endoluminal Fundoplication Using Esophyx® for GERD Barry P. McMahon*, Blair A. Jobe, Stefan J. Kraemer, Flemming H. Gravesen, Nicole Bouvy, Bart Witteman, Cedric S. Lorenzo, Michael M. Owens, John G. Hunter, Robert W. O'Rourke

S1110

A New Removable Endoluminal Prosthesis for Control of Gastroesophageal Reflux (GER) Javaid Butt, P.j. Byrne*, Niall Behan, Wayne Allen

S1111

Impedance-pH Testing Predicts Successful Response to Laparoscopic Nissen Fundoplication Neeraj Sharma*, Jason A. Wilson, Amit Agrawal, Janice Freeman, Marcelo F. Vela, Donald O. Castell

S1095

MAY 18 S1096

S1097

S1098

S1099

S1100

P-142

Symptom Relief Assessed By Reflux Questionnaire (Request™): A Superior Clinical Endpoint Compared to Investigator-Assessed Heartburn? Gerald J. Holtmann*, Richard H. Hunt, Jan F. Tack, Astrid K. Korell, Hubert Doerfler, Peter H. Katelaris Nighttime GERD Symptoms Associated with Dyspepsia, Esophageal Discomfort, and Extraesophageal Complaints Improvement After Treatment with Pantoprazole Magnesium; 40 mg Daily for 28 Days Luis Lopez, Juan C. Lopez-Alvarenga*, Anthony G. Comuzzie, Jorge Gonzalez, Yasmin Crespo, Jose-Antonio Vargas Symptoms Improvement Evaluation in GERD Patients: Assessed Independently By a Physicians and Patients Using the Request Questionnaire Before and After Pantoprazole Magnesium 40mg o.d. for 28 Days Treatment Luis Lopez, Juan C. Lopez-Alvarenga*, Paul Higgings, Anthony G. Comuzzie, Jorge Gonzalez, Yasmin Crespo, Jose-Antonio Vargas Can Alginates Prevent Pepsin and Bile Acid Damage to the Esophagus During Gastro-Esophageal Reflux? Vicki Strugala*, Jeanine Avis, Lesley M. Johnstone, Ian G. Jolliffe, Peter W. Dettmar Pre-Treatment RequestTM Scores Can Predict Response to PPI Therapy in GERD Patients Robert Heading*, Hubert Doerfler, Peter Berghoefer, Holger Schmitt, Hubert Monnikes

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL AGA Institute Poster Session 8:00 AM - 5:00 PM

S1123

Yield of High-Grade Dysplasia and Intra-Mucosal Carcinoma (Tis) Based On Adenomas Size. Results of a Prospective Population-Based Series of Colonoscopies Following a Positive Faecal Occult Blood Test (FOBT) Result Jean-François Bretagne*, Christine Piette, Gaud Mallard, Sylvain Manfredi, Gérard Durand

S1124

Potential Usefulness of Predicting Stage of Colorectal Cancer By Fecal RNA Test Shigeru Kanaoka*, Ken-ichi Yoshida, Yasushi Hamaya, Mutsuhiro Ikuma, Akira Hishida

S1125

Factors Associated with Advanced Histology in Small Colonic Polyps in a Racially Diverse Population Sonia Kupfer*, Roya Fathi, Karen E. Kim

S1126

Detection of Colorectal Neoplasia Through Analysis of Fecal DNA Methylation Takeshi Nagasaka*, Hiromi Sasamoto, Dong Sheng Sun, Tetsuhiro Oka, Keisuke Toda, Nobumasa Taniguchi, Minoru Koi, Naoshi Nishida, C. R. Boland, Ajay Goel, Nagahide Matsubara

S1127

Endoscopic Evaluation of the Upper Gastrointestinal Tract in HIV+ Patients with Cutaneous Kaposi's Sarcoma Ana Luiza Werneck-Silva*, Ivete B. Prado

S1128

Identification of CD24, a Novel Biomarker for the Early Detection of Colorectal Cancer (CRC), Using Peripheral Blood Mononuclear Cells Sarah Kraus, Lior Galazan, Inna Naumov, Einat Shmueli, Shiran Shapira, Diana Kazanov, Ravit Geva, Arie Figer, Nadir Arber*

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: SCREENING AND DIAGNOSIS (I) Participants will be able to: • Learn more about screening and diagnosis in GI cancers. S1112



Effect of Warfarin On Positive Predictive Value for FOBT in Asymptomatic Persons LuLu Iles-Shih*, Judith Collins, Nora Mattek, David A. Lieberman

S1113

Ethnic Differences in Findings On Screening Colonoscopy Roy Yen*, Ognian A. Pomakov, Shahid Mehboob, Michael D. Sitrin

S1114

Association of Large Hyperplastic Polyps with Synchronous Advanced Colorectal Neoplasia Dan Li*, Chengshi Jin, Charles McCulloch, Barry M. Berger, Thomas F. Imperiale, Jonathan P. Terdiman

S1115

S1116

A Prognostic/Diagnostic DNA Fluorescent in situ Hybridization Probe Set for Identifying Patients At Risk and (Early) Neoplasia in Barrett's Esophagus Rygiel M. Agnieszka, Francesca Milano, Wytske Westra, Brenda Elzer, Annet Schaap, Jacques J. Bergman, Kausilia K. Krishnadath*



Incidence of Right-Sided Colorectal Cancers After Breast and Other Gynecological Cancers: A Population-Based Study Linda Y. Tang*, Zoann Nugent, Alain Demers, Syed A. Rasul, Harminder Singh

S1117

Faecal Occult Blood Tests: Immunological Superior to Guaiac Based? Frank A. Oort*, Jochim S. Terhaar sive Droste, Mike E. Craanen, René W. van der Hulst, Henk van Heukelem, Ruud J. Loffeld, Liesbeth Mutsaers, Roy van Wanrooy, Eric C. Wesdorp, Suzanne J. van de Reijt, Laura de Baaij, Gerrit A. Meijer, Chris J. Mulder

S1118



Prospective Comparative Evaluation of An Office Based Rapid Immunological Test with a Guaiac Based Fecal Occult Blood Test for Colorectal Cancer Screening in General Population with Average-Risk Yogesh Shastri*, Stefan Loitsch, Roland Nowak, Nada Povse, Jürgen Stein

S1120

A Mailed Educational Reminder Significantly Increases Compliance with Fecal Occult Blood Testing for Colorectal Cancer Screening Jeffrey K. Lee*, Veronica Reis, Shanglei Liu, Chen Mu, Lorraine Conn, Erik J. Groessl, Theodore G. Ganiats, Samuel B. Ho

S1121

Medicaid Patients with Colorectal Cancer Are Rarely Diagnosed By Screening Colonoscopy Matthew T. Weed*, Andrea Rosenberg, Lillian Burke, Mahfuzul Haque, Paul Vos, Merrill Brinson, Amit Aravapalli

S1122

Screening for Colorectal Cancer with Faecal Occult Blood Test (FOBT): Findings of the Second Round Compared with Those of the First Round in One French District Jean-François Bretagne*, Christine Piette, Sylvain Manfredi, Gaud Mallard, Gérard Durand

S1129

Risk of Neoplasia in First-Degree Relatives of Patients with Colorectal Cancer. Results of a Prospective RegioWide Colonoscopy Screening Program Angel Ferrandez*, Ricardo Sainz, Angel I. Lanas

S1130

Direct Contact with First-Degree Relatives of Patients with Colon Cancer Achieves High Screening Rates in This High-Risk Population Angel Ferrandez*, Maria Jose Marco, Ricardo Sainz, Angel I. Lanas

S1131

Changing Colonic Neoplastic Developments in An Italian Referral Population Vito D. Corleto*, Ermira Zykaj, Maria S. Cattaruzza, Antonella Lamazza, Cristina Nisita, Cristiano Pagnini, Giovanna Margagnoni, Emanuela Pilozzi, Antonella Carnuccio, Emilio Di Giulio, Giancarlo D'Ambra, Mario Ferri, Luigi Masoni, Vincenzo Ziparo, Gianfranco Delle Fave

S1132

Accept or Decline Fecal Occult Blood Screening for Colorectal Cancer: The Participants View Anne Floortje van Rijn*, Leo van Rossum, Marije Deutekom, Robert Laheij, Paul Fockens, Patrick Bossuyt, Evelien Dekker, Jan B. Jansen

S1133

Audit of Colonic Polyp Follow Up in a Scottish Teaching Hospital San C. Kong*, Ying J. Lum, Rosemary J. Hollick, John F. MacKenzie, John Morris, Adrian Stanley, Ruth J. Gillespie, Ruth F. McKee, John H. Anderson, Ewan Forrest

S1134

Screening for Colorectal Cancer: A Blinded Multicenter Phase II Diagnostic Study for Validation of a DNA Based Stool Test (Genefec2©) Matthias M. Dollinger*, Cora Gromann, Ines Kühne, Susanne Behl, Johannes Haerting, Wolfgang E. Fleig

S1135

Your Disease Risk (YDR) and Risk Stratification for Advanced Colorectal Neoplasia (Acn) Paul C. Schroy, Lynne B. Ahn*, Julie Glick, Patricia Robinson, Maria Lydotes, Shamini Mylvaganam, Jacqueline Ashba, Michael Atkinson, Graham A. Colditz

Denotes DDW Poster of Distinction

P-143

S U N D A Y MAY 18

POSTER SESSIONS—CLINICAL S1136

Prevalence of Adenomas in Familial Colorectal Cancer Andrea E. van der Meulen - de Jong*, H. Wolters, A. M. Witte, J. Vecht, Rogier W. Ten Hove, J. Salemans, Fokko M. Nagengast, Jan H. Kleibeuker, G. F. Nelis, Hans F. Vasen

S1137

Prevalence of Low and High Grade Diminutive Adenomas in Patients Submitted to Routine Colonoscopy Dalton M. Chaves*, Frank S. Nakao, Beatriz M. Sugai, Maria Rachel S. Rohr, Nelson T. Miyajima, Jose Olympio Meirelles-Santos, Regina R. Imada, Ermelindo Della Libera, Toshiro Tomishige

S1138

S1139

S1140

S U N D A Y MAY 18

S1141

Risk Stratification Among Individuals Attending Population-Based Colorectal Cancer Screening in the Netherlands Lieke Hol*, M. E. Leerdam van, Marjolein van Ballegooijen, Vincent de Jonge, Jaqueline C. Reijerink-Verheij, Anneke van Vuuren, J. D. Habbema, Ernst J. Kuipers Colorectal Cancer Screening: A Randomized Controlled Trial with Annual Fecal Occult Blood Test or Flexible Sigmoidoscopy Every 5 Years - Preliminary Results Anabela G. Pinto, Paula Chaves, Rita Sousa, Isabel Claro, Pedro A. Lage, Alexandra Suspiro, Sandra Faias, Sara Ferreira*, Susana Mão de Ferro, Luis F. Contente, Miguel Gouveia, Jorge Soares, Carlos N. Leitão Does the Presence of Synchronous Hyperplastic Polyps Increase the Risk of Recurrent Neoplasms Among Patients with Colorectal Adenomas? Adeyinka O. Laiyemo*, Gwen A. Murphy, Leah B. Sansbury, Zhuoqiao Wang, Paul Albert, Pamela Marcus, Robert E. Schoen, Amanda J. Cross, Arthur Schatzkin, Elaine Lanza Recent Trends for Colorectal Cancer Screening in HIVInfected Patients Veron Browne-McDonald*, Shahzad Iqbal, Bishnu Sapkota, Prashant Sharma, Hashem Vahabzadeh-Monshie, Vilma s. Vas, Rekha Khurana, Muhammad Pervaiz, Ofem Ajah, Marilyn Martin-Naar, Maurice A. Cerulli

AGA Institute Poster Session 8:00 AM - 5:00 PM

S1146

No Effect of Gut-Directed Hypnotherapy On Rectal Sensitivity in Children with Functional Abdominal Pain and Irritable Bowel Syndrome Maartje M. van den Berg*, Arine M. Vlieger, Carla MenkoFrankenhuis, Marloes E. Bongers, Marc A. Benninga

S1147

Gastrointestinal (GI) Permeability Is Associated with Trait Anxiety in Children with Functional Abdominal Pain (FAP) and Irritable Bowel Syndrome (IBS) Robert J. Shulman*, Danita I. Czyzewski, Mariella Lane, Monica Jarrett, Robert L. Burr

S1148

A Comparison Between Solid-State vs. Water Perfused Catheters for Colonic Manometry in Children Olivia Liem*, Frances L. Connor, Narasimha S. Reddy, Hayat M. Mousa, Marc A. Benninga, Carlo Di Lorenzo

S1149

Magnetic Resonance Imaging of the Lumbosacral Spine in Children with Chronic Constipation and Functional Non-Retentive Fecal Incontinence: A Prospective Study Noor Bekkali*, Marloes E. Bongers, Eveline E. Hagebeuk, Michiel P. van Wijk, Rick R. Van Rijn, Marc A. Benninga

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sponsored by: Growth, Development & Aging

CLINICAL PEDIATRIC GASTROENTEROLOGY: INFLAMMATORY BOWEL DISEASE Participants will be able to: • Learn about emerging concepts in pediatric inflammatory bowel disease. S1150

Influence of Parental Height in Disease Characteristics of Pediatric-Onset Inflammatory Bowel Disease Jessica J. Lee*, Johanna C. Escher, Melissa J. Shuman, Peter Forbes, Richard J. Grand

S1151

A Detailed Investigation Into Epidemiological Risk Factors for Childhood Onset Inflammatory Bowel Disease in Scotland Johan Van Limbergen*, Elizabeth Hobbs, Richard K. Russell, Elaine Nimmo, Hazel E. Drummond, Linda Smith, Peter M. Gillett, Paraic McGrogan, Lawrence Weaver, Michael W. Bisset, Gamal Mahdi, Jack Satsangi, David C. Wilson

S1152

Childhood Onset Inflammatory Bowel Disease Has a More Extensive Disease Phenotype in Comparison to Adult Onset IBD Using the Montreal Classification Johan Van Limbergen*, Richard K. Russell, Hazel E. Drummond, Nicola Round, Linda Smith, Elaine Nimmo, Ian D. Arnott, Peter M. Gillett, Paraic McGrogan, Lawrence Weaver, Michael W. Bisset, Gamal Mahdi, David C. Wilson, Jack Satsangi

S1153

An Induction Dose of 12 Mg/D Budesonide Improves Clinical Efficacy in Comparison to a Standard Continuous Dose of 9 mg/d Active Pediatric Crohn's Disease Arie Levine*, Michal Kori, Gabriel Dinari, Efrat Broide, Ron Shaoul, Baruch Yerushalmi, Markus Proels, Roland Greinwald

S1154

A Comprehensive Review of the English Language Evidence Base for the Management of Paediatric Inflammatory Bowel Disease (IBD) Illustrates the Difficulties for Evidence-Based Clinical Guideline Formation David C. Wilson*, Working Group Inflammatory Bowel Disease

Sails Pavilion San Diego Convention Center

Sponsored by: Growth, Development & Aging

CLINICAL PEDIATRIC GASTROENTEROLOGY: FUNCTIONAL AND MOTILITY DISORDERS Participants will be able to: • Learn about emerging concepts in pediatric functional and motility disorders. S1142

Long-Term Follow-Up and Outcome of a Cohort of Pediatric Patients with Functional Constipation Marloes E. Bongers*, Michiel P. van Wijk, Marc A. Benninga

S1143

Non-Specific Acute Gastroenteritis Does Not Lead to Post - Infectious Chronic Gastrointestinal Complaints in the Pediatric Population: A Prospective Study Nader N. Youssef*, Heather Jeney

S1144

Parental Employment and Marital Status: Indicators of Coping Style in Childhood Recurrent Abdominal Pain Nader N. Youssef*, Shelby Langer, Dennis L. Christie, Lynn S. Walker, Joan Romano, Andrew D. Feld, Sheri A. Ballard, William E. Whitehead, Rona L. Levy

S1145

P-144

Esophageal Clearance Is Delayed in Fundoplication Patients with Dysphagia: A Study Using Esophageal Manometry with Impedance in Children Rachel Rosen*, Jessica C. Lewis, Samuel Nurko

Sails Pavilion San Diego Convention Center

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL S1155

A Population-Based Ecological Study Identifies Population Density, Urban/Rural Location, and Spatial Clustering As Determinants of Susceptibility to EarlyOnset Inflammatory Bowel Disease in Scotland David C. Wilson*, Kevin G. Pollock, Johan Van Limbergen, Emma L. Armitage, Marian C. Aldhous, Hazel E. Drummond, Helen E. Ternent, Giles T. Innocent, Jack Satsangi

S1156

Fatigue and Health Related Quality of Life (HRQOL) in Pediatric Inflammatory Bowel Disease (IBD) Seth B. Marcus*, Jennifer A. Strople, Katie Neighbors, Jill Weissberg-Benchell, James W. Varni, Estella M. Alonso

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

S1164



Detailed Inspection of the Mucosal Morphology in Barrett's Esophagus By Narrow Band Imaging Has No Additional Value Over Inspection with High-Resolution Endoscopy: An International Inter-Observer Study Using Expert and Non-Expert Endoscopists Wouter L. Curvers*, Clarisse J. Böhmer, Rosalie C. MallantHent, Anton H. Naber, Cyriel Ponsioen, Krish Ragunath, Rajvinder Singh, Michael B. Wallace, Herbert C. Wolfsen, Louis-Michel Wong Kee Song, Robert Lindeboom, Paul Fockens, Jacques J. Bergman

S1165

Diagnostic Precision of Narrow Band Imaging (NBI) Versus Chromoendoscopy for Lesion Characterization At Colonoscopy: A Meta Analysis George E. Reese*, James E. East, Emile Tan, Brian P. Saunders, Paris P. Tekkis

S1166

Does the New Generation Narrow Band Imaging System Improve the Detection of Neoplasia in Patients with Longstanding Ulcerative Colitis? a New Randomized Cross-Over Study Comparing Narrow Band Imaging and High Resolution Endoscopy Frank J. van den Broek*, Paul Fockens, Pieter C. Stokkers, Cyriel Ponsioen, Susanne van Eeden, Johannes B. Reitsma, Evelien Dekker

Sponsored by: Imaging & Advanced Technology

ENHANCED/ CROSS SECTIONAL IMAGING Participants will be able to: • Evaluate enhanced cross sectional imaging. S1157

CT Colonography in Patients with Incomplete Conventional Colonoscopy: Evaluation of a Colon Dissection Mode (Filet View) for Virtual Colonoscopy Juergen M. Gschossmann*, Hanno Hoppe, Peter Vock, Bettina Saar

S1167

Hyperplastic Polyposis Syndrome: Classification of Polyps Using High Resolution Endoscopy, Narrow-Band Imaging and Autofluorescence Imaging Karam S. Boparai*, Frank J. van den Broek, Susanne van Eeden, Paul Fockens, Evelien Dekker

S1158

Clostridium difficile Colitis in An Inpatient Population: Value of CT in Establishing Prognosis Anil R. Balani*, Gene Young Im, Paul Panzarella, Cheng Ting Lin, Rani J. Modayil, Simcha Pollack, Douglas S. Katz, James H. Grendell

S1168

In Vivo Endocytoscopy of Normal Digestive Tract Mucosa: A Pilot Study Emmanuel Coron*, Tamara Matysiak-Budnik, Jean-François Mosnier, Marc Le Rhun, Haruhiro Inoue, Jean Paul Galmiche

Blood Flow Assessed By Perfusion CT Reflects Angiogenesis and Correlates with Prognostic Factors in pts with Pancreatic Endocrine Tumors Gaspard d'Assignies*, Anne Couvelard, S. Bahrami, Marie Pierre Vullierme, Pascal Hammel, Philippe Lévy, Alain Sauvanet, Philippe B. Ruszniewski, Valérie Vilgrain

S1169

Comparative Performance Assessment of Gastroenterologist and Radiologist in the Detection of Polyps in CT Colonography with Two Different Preparations Koichi Nagata*, Tomohiko Okawa, Akihiro Honma, Shungo Endo, Shin-ei Kudo, Hiroyuki Yoshida

S1170

The Effect of Virtual Colonoscopy On Colorectal Cancer Screening in a Nonadherent Population Wendy W. Ho*, Darcy Broughton, G Scott Gazelle, Chin Hur

S1171

Colonic Thickening On Abdominal Computerised Tomography, How Often Are the Radiologists Right? Gareth Parkes*, Sarah Natas, Dean Borrow, Jeremy D. Sanderson

S1172

Prevalence of High Grade Malignant Polyps in Screening Populations with Computer Tomographic Colonography (CTC) and Colonoscopy Andrew Gentry, Amer Skopic*, James Duncan, Michael P. McNally, Cathy Dykes, Jayde E. Kurland

S1159

S1160

S1161



Detection of Cholangiocarcinoma In-Vivo Using Miniprobe-Based Confocal Microscopy Alexander Meining*, Eckart Frimberger, Valentin Becker, Stefan von Delius, Claus von Weyhern, Roland M. Schmid, Christian Prinz

S1162



Confocal Laser Endomicroscopy Is An Effective and Safe Diagnostic Tool in GI-Endoscopy Ralf Kiesslich*, David P. Hurlstone, Kerry B. Dunbar, Marcia I. Canto, Martin Goetz, Arthur Hoffman, Michael Vieth, Stefan Biesterfeld, Peter R. Galle, Markus F. Neurath

S1163

High-Resolution Endoscopy Plus Chromoendoscopy or Narrow-Band Imaging in the Detection of Dysplasia and Colonic Cancer in Long Standing Inflammatory Bowel Disease: A Prospective Randomized Crossover Study maria pellise*, Michel Zabalza, Cristina Rodriguez de Miguel, Miquel Sans, Montserrat Aceituno, Elena Ricart, Gloria Fernandez-Esparrach, Angels Gines, Oriol Sendino, Josep M. Bordas, Josep M. Pique, Julian Panes, Josep Llach



Miniprobe Based Confocal Fluorescence Microscopy Is Feasible for Recognition of Histological Features In-Vivo for the Prediction of Final Histopathology in Patients with Longstanding Ulcerative Colitis Frank J. van den Broek*, Susanne van Eeden, Paul Fockens, Evelien Dekker

Denotes DDW Poster of Distinction

P-145

S U N D A Y MAY 18

POSTER SESSIONS—CLINICAL S1182

Serum Protein Signatures Determined By Mass Spectrometry (SELDI-ToF) Accurately Distinguishes Crohn's Disease (CD) from Ulcerative Colitis (UC) Venkataraman Subramanian*, Devika Subramanian, Richard C. Pollok

S1183

A Combination of Serum Adiponectin, Pepsinogen I and Anti-Saccharomyces Cerevisiae Antibody (ASCA) Levels Can Accurately Distinguish Patients with Crohn's Disease Involving the Small Bowel from Colonic Crohn's Disease Venkataraman Subramanian*, Geetha Balarajah, Richard C. Pollok

S1184

The Manitoba Index: Psychometric Evidence for a New and Simple Indicator of IBD Activity Ian Clara*, Lisa M. Lix, John Walker, Lesley A. Graff, Norine Miller, Linda Rogala, Patricia Rawsthorne, Charles N. Bernstein

S1185

Faecal Calprotectin's Utility in the Prediction of Inflammatory Bowel Disease (IBD) Relapses Javier P. Gisbert*, Fernando Bermejo, Jl Perez-Calle, Carlos Taxonera, Isabel Vera, Yago Gonzalez-Lama, Alicia Algaba, P. Lopez-Serrano, N. López-Palacios, Marta Calvo, Adrian G. McNicholl, Ja Carneros, M. Velasco, José Maté-Jiménez

S1186

The Diagnostic Accuracy of Faecal Calprotectin in Inflammatory Bowel Disease (IBD): A Systematic Review Javier P. Gisbert*, Adrian G. McNicholl

S1187

Inflammatory vs. Fibrotic Strictures: Use of CT Enterography to Address a Common Clinical Dilemma Jeremy Adler*, Darashana Punglia, Maneesh Dave, Paul L. Sonda, Joel F. Platt, Ellen M. Zimmermann

Colonic Pre-Inflammation in Quiescent Ulcerative Colitis Is Due to the Presence of Lamina Propria Residing Cells Jacob T. Bjerrum*, Jørgen Olsen, Ole Haagen Nielsen

S1188

Magnetization Transfer MRI Detects Intestinal Fibrosis, Not Inflammation in An Animal Model of Crohn's Disease Jeremy Adler*, Scott D. Swanson, Phyllissa Schmiedlin-Ren, Peter D. Higgins, Alexandros D. Polydorides, Barbara J. McKenna, Ellen M. Zimmermann

Protein Microarray Experiments for Profiling of the Autoimmune Response in Inflammatory Bowel Disease; Identification of PHLA1 Nathalie Vermeulen*, Severine Vermeire, Georges Michiels, Marie Joossens, Paul J. Rutgeerts, Xavier Bossuyt

S1189

Renovating the Domain Structure of the Inflammatory Bowel Disease Questionnaire Dahlia Awais*, Peter D. Higgins

S1190

The Differential Expression of MicroRNAs in Patients with Ulcerative Colitis Feng Wu, Michelle N. Zikusoka, Themistocles Dassopoulos, Theodore M. Bayless, Steven R. Brant, Shukti Chakravarti, John H. Kwon*

S1191

Use of Methodological Standards in IBD Diagnosis Research Thomas A. Ullman*, Arvind J. Trindade, Jianlin Xie, Yevgenia Pashinsky

S1192

A Retrospective Analysis of Small Bowel MRI in Evaluation of Disease Activity in Ileal Crohn's Disease Charles W. Lees*, Constantinos A. Parisinos, Deepak Subedi, Alan G. Shand, Ian D. Arnott, Stephen Glancy, Jack Satsangi

S1193

Phenotypic Associations of Crohn's Disease with Antibodies to Flagellins A4-Fla2, Fla-X, ASCA, pANCA and CARD15 Mutations in a Swiss Cohort Alain Schoepfer*, Thomas Schaffer, Stefan Mueller, Erik Vassella, Beatrice Seibold-Schmid, Frank Seibold

S1194

Ulcerative Colitis Patients After Pouch Surgery Have Crohn's Disease Associated Serologies Which Are Associated with Pouch Inflammation Iris Dotan*, Hagit Tulchinsky, Hasya Zinger, Noya Horowitz, Ilana Goldiner, Eli Brazowski, Zamir Halpern

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

DIAGNOSTICS AND DISEASE ASSESSMENT I Participants will be able to: • Become familiar with disease assessment. S1173

S U N D A Y

Development of a Novel Disease Activity Index for Intestinal Behcet's Disease Jae Hee Cheon*, Dong Soo Han, Byong Duk Ye, Sung-Ae Jung, Young Sook Park, You Sun Kim, Joo Sung Kim, Chung Mo Nam, Youn Nam Kim, Suk-Kyun Yang, Won Ho Kim

S1174

Assessing the Presence of Intestinal Inflammation in IBD and IBS: Comparison of Fecal Lactoferrin, CRP and Activity Indices with Ileocolonoscopy Jost Langhorst*, James H. Boone, Andreas Rueffer, Andreas Michalsen, Gustav J. Dobos

S1175

Elevated Faecal Calprotectin Levels Are Associated with the Need for Colectomy in Acute Severe Ulcerative Colitis Gwo-Tzer Ho*, Huey Miin Lee, Gordon W. Brydon, Nicola C. Hare, Terence Ting, Hazel E. Drummond, Alan G. Shand, Ian D. Penman, David C. Bartolo, Graeme Wilson, Malcolm G. Dunlop, Kelvin R. Palmer, Ian D. Arnott, Jack Satsangi

S1176

S1177

MAY 18

S1178

S1179

S1180

S1181

P-146

CT Enterography Findings Correlate with Tissue Inflammation But Not Fibrosis in Resected Small Bowel Crohn's Disease Jeremy Adler*, Darashana Punglia, Jonathan R. Dillman, Alexandros D. Polydorides, Mahmoud M. Al-Hawary, Maneesh Dave, Elaine M. Caoili, Paul L. Sonda, Joel F. Platt, Barbara J. McKenna, Ellen M. Zimmermann IgG Oligosaccharide Alterations Are a Novel Diagnostic Marker for Disease Activity and the Clinical Course of Inflammatory Bowel Disease Shinichiro Shinzaki*, Hideki Iijima, Takatoshi Nakagawa, Satoshi Egawa, Sachiko Nakajima, Jumpei Kondo, Shuji Ishii, Yoshimi Kakiuchi, Tsutomu Nishida, Tatsuya Kanto, Masahiko Tsujii, Shingo Tsuji, Akihiro Kondo, Eiji Miyoshi, Norio Hayashi Crohn's Disease Is Associated with a Specific Urinary Metabolic Profile Horace R. Williams*, I Jane Cox, Bernard V. North, Venisha M. Patel, Sara E. Marshall, Derek P. Jewell, Subrata Ghosh, Huw J. Thomas, Julian P. Teare, Simon Jakobovits, Sebastian S. Zeki, Kenneth I. Welsh, Simon D. Taylor-Robinson, Timothy Orchard Yield of Neoplasia from Random Biopsies Plus Chromoendoscopy in Patients Undergoing Surveillance of Colitis Melissa A. Munsell*, Nirosha Mahendraratnam, Theodore M. Bayless, Themistocles Dassopoulos

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL S1195

Increased Bone Resorption and Lower Bone Density in Microscopic Colitis Pál Miheller*, Gábor Lakatos, Katalin Müllner, Györgyi Müzes, Tamás Zágoni, Anna M. Németh, Miklós Tóth, László Herszényi, Zsolt Tulassay

S1208

Application of Fourier Transform Near-Infrared Spectroscopy of Serum Samples in Patients with Inflammatory Bowel Disease - a Pilot Study Stephan L. Haas*, Ulrich Böcker, Peter Bugert, Manfred V. Singer, Juergen P. Backhaus

S1196

S100 Proteins in Inflammatory Bowel Disease and Irritable Bowel Syndrome Helmut Wittkowski, Jost Langhorst, Thomas Kaiser, Andreas Rueffer, Johannes Roth, Dirk Foell*

S1209

S1197

Metabonomics As a Diagnostic Tool of Ulcerative Colitis Jacob T. Bjerrum*, Yulan Wang, Ole Haagen Nielsen, Jørgen Olsen

Does Self-Reported Quality of Life Correlate with Disease Activity in All Crohn's Disease Patients? Mazen Issa*, Ashwin N. Ananthakrishnan, Dawn B. Beaulieu, Mark Mulcaire-Jones, Joshua F. Knox, Susan Skaros, Jeanne Emmons, Kathryn Lemke, David G. Binion

S1210

Clinical, Serological and Genetic Predictors of Postoperative Recurrence in a Single-Center Prospectively Collected Cohort of Crohn's Disease Patients Dermot P. McGovern*, Kent D. Taylor, Carol J. Landers, Debbie Dutridge, Carrie A. Derkowski, Ling Mei, Andrew Ippoliti, Eric A. Vasiliauskas, Marla C. Dubinsky, Jerome I. Rotter, Stephan R. Targan, Phillip Fleshner

S1211

Clinical Benefit of CT Enterography in Suspected or Established Crohn's Disease: Impact On Patient Management and Physician Level of Confidence David H. Bruining*, Hassan A. Siddiki, Joel G. Fletcher, Jeff L. Fidler, James E. Huprich, Jayawant N. Mandrekar, William S. Harmsen, Karen A. Hanson, Paul E. Evans, Steven B. Ingle, Yuning Xiong, Kenneth W. Schroeder, William J. Tremaine, Darrell S. Pardi, William J. Sandborn, Edward V. Loftus

S1212

Scintigraphic Identification of Pancolitis and Distal Ileitis Using 99mtc-Labeled Interleukin-8 in Inflammatory Bowel Disease Dirk J. De Jong*, Joost PH Drenth, Frans HM H. Corstens, Johan Tielen, Otto C. Boerman, Wim J. Oyen

S1198

Diagnostic Value of FDG-PET and PET-CT in Pediatric Patients with Chronic Inflammatory Bowel Disease Niklas Jasper, Jan Daebritz, Helmut Wittkowski, Markus Loeffler, Matthias Weckesser, Dirk Foell*

S1199

Female Gender Negatively Impacts Health Related Quality of Life (HRQOL) in IBD: Performance of the SIBDQ in a Long-Term Cohort Study Dawn B. Beaulieu*, Mark Mulcaire-Jones, Ashwin N. Ananthakrishnan, Mazen Issa, Joshua F. Knox, Susan Skaros, Kathryn Lemke, Jasmohan S. Bajaj, David G. Binion

S1200

S1201

S1202

S1203

S1204

Markers of Inflammation in Women with Crohn's Disease During Pregnancy Dawn B. Beaulieu*, Mark Mulcaire-Jones, Mazen Issa, Ashwin N. Ananthakrishnan, Joshua F. Knox, Susan Skaros, Kathryn Lemke, Jasmohan S. Bajaj, David G. Binion, Mary F. Otterson Patient-Reported Utilization of Health Care Resources in Ulcerative Colitis and Crohn's Disease Matches Their Health Care Costs Selwyn H. Odes*, Hillel Vardi, Michael Friger, Pia S. Munkholm, Reinhold W. Stockbrugger, Tomm Bernklev, Bjorn Moum The Effect of Time, Baseline Activity and Surgery On Crohn's Disease Activity Index (CDAI) Response Definitions to Optimize Treatment Effect Difference Kelvin T. Thia*, William J. Sandborn, James D. Lewis, Edward V. Loftus, Brian Feagan, A. Hillary Steinhart, Stephen B. Hanauer, Tore Persson, Bruce E. Sands Patients with Inflammatory Bowel Disease Are Insufficiently Educated About Their Disease and Associated Risks Judith E. Baars*, Corey A. Siegel, Adriaan van 't Spijker, E. J. Kuipers, Christien J. van der Woude Prediction Analysis of Microarrays to Develop An Accurate MicroRNA Panel for the Diagnosis of IBDNeoplasia Alexandru Olaru*, Florin M. Selaru, Yuriko Mori, Kwisa Kang, Zhe Jin, Stefan David, Bogdan C. Paun, Tetsuo Ito, Yulan Cheng, Rachana Agarwal, Jian Yang, James P. Hamilton, John M. Abraham, Stephen J. Meltzer

S1205

Comparative Analysis of IBD Serology Ira Shafran*, Patricia Burgunder, Terri Aplin

S1206

Magnetic Resonance Imaging for Suspected IBD in a Pediatric Population Lissy d. Ridder*, Karin Horsthuis, Anne M. Smets, Rutger A.J. Nievelstein, Maarten van Leeuwen, Marc A. Benninga, Roderick Houwen, Jaap Stoker

S1207

Predicting Mucosal Inflammatory Activity in Crohn's Disease: A New Non-Endoscopic Index Itta Minderhoud*, Melvin Samsom, Matthijs P. Schwartz, E. W. Steyerberg, Bas Oldenburg

S1213

Gene Expression Array Based Identification of Active IBD in Colon Biopsies and Peripheral Blood: Correlation Between mRNA and Protein Expression Profiles Ferenc Sipos*, Orsolya Galamb, Sandor Spisak, Norbert Solymosi, Tibor Krenacs, Kinga Tóth, Anna M. Németh, Béla Molnár, Zsolt Tulassay

S1214

How Do IBD Patients Get Their Information? a Look At IBD Information Resources and Perception of Doctor Message in Patients with Extensive Crohn's or Ulcerative Colitis Leanne N. Torgersen*, Adam S. Cheifetz, Francis A. Farraye, Sonia Friedman

S1215

Capsule Endoscopy and Proximal Small Bowel Lesions in Patients with Crohn's Disease Carmelina Petruzziello*, Emma Calabrese, Sara Onali, Giovanna Del Vecchio Blanco, Giovanna Condino, Francesca Zorzi, Francesco Pallone, Livia Biancone

S1216

ASCA in African American Patients with Crohn's Disease Themistocles Dassopoulos*, Geoffrey C. Nguyen, Monica Vladut Talor, Kim L. Isaacs, James D. Lewis, Michael S. Gold, John F. Valentine, Duane T. Smoot, Mary L. Harris, Theodore M. Bayless, Carol L. Burek, Steven R. Brant

S1217

Metabolomics in Inflammatory Bowel Disease: Differentiating Patients with or Without IBD Jesse S. Siffledeen*, Kathryn N. Rankin, Hao Fu, Levinus A. Dieleman, Carolyn Slupsky, Richard Fedorak

S1218

Prevalence, Predisposing Factors and Clinical Relevance of Small Intestinal Bacterial Overgrowth in Patients with Crohn's Disease Jochen Klaus*, Guido Adler, Georg B. von Boyen

Denotes DDW Poster of Distinction

P-147

S U N D A Y MAY 18

POSTER SESSIONS—CLINICAL

S U N D A Y

S1219

Assessment of Crohn's Disease Recurrence After IleoColonic Resection: Correlation Between Endoscopic Score and Sonographic Findings Emma Calabrese*, Carmelina Petruzziello, Sara Onali, Giovanna Condino, Francesca Zorzi, Francesco Pallone, Livia Biancone

S1229

Genotype and Phenotype Analysis of Thiopurine-MethylTransferase (TPMT) in a Northern Italian Population Marco Daperno*, Roberto Canaparo, Raffaello Sostegni, Annalisa Vernetto, Loredana Serpe, Pier L. Calvo, Sergio D'Antico, Lucia Crocellà, Franco Castagno, Angelo Pera, Gian Paolo Zara, Rodolfo Rocca

S1220

Distinct Cytokine Patterns As Effective Indicators of Disease Activity and Severity in IBD Philip Alex*, Nicholas C. Zachos, Laurie S. Conklin, John H. Kwon, Mary L. Harris, Theodore M. Bayless, Michael Centola, Xuhang Li

S1230

Which 5-ASA? Variation in Colonic Mucosal Concentration of Different Pharmaceutical mesalamine Formulations Renata D'Incà*, Martina Paccagnella, Romilda Cardin, Sandra Voltan, Vincenzo Baldo, Giacomo C. Sturniolo

S1221

Computed Tomography Enterography and Small Bowel Ultrasound in Assessing Ileal Crohn's Disease Activity Alessandra Losco*, Chiara Trattenero, Mirella Fraquelli, Laura Virginia Forzenigo, Sara Massironi, Lorena Pirola, Dario Conte, Pietro Biondetti, Guido Basilisco

S1231

S1222

Faecal Lactoferrin- a Novel Test to Differentiate Between Irritable or Inflamed Bowel? Reena Sidhu, John S. Leeds*, Laura Foye, Perm Wilson, Alison Wright, Alan J. Lobo, Mark E. McAlindon, David S. Sanders

Predictors for Failing Thiopurine Therapy in IBD Patients; Treated At An Academic or General District Hospital Bindia Jharap*, M. Seinen, Ronald K. Linskens, Jan Kees Kneppelhout, Chris J. Mulder, Nanne de Boer, Ad A. van Bodegraven

S1232

The TOUCH™ Program and Risk Management Plan for the Administration of Natalizumab: Lessons and Updated Safety Results from the Use of Natalizumab in Patients with Relapsing Multiple Sclerosis and Implications for Potential Use in Crohn's Disease Bruce E. Sands*, Gordon Francis, Glyn Belcher, Mariska Kooijmans, Richard Kim, Frances Lynn, Carmen Bozic, William Maier, Jean-Frédéric Colombel

S1233

Evaluation of Long Pentraxin Ptx3 for the Inflammation Marker in the Patients with Ulcerative Colitis Shingo Kato*, Mina Sagara, Kazuro Itoh, Koji Yakabi

S1234

Patient Trust in Physicians and Race Are Independent Predictors of Adherence to Medical Management in Inflammatory Bowel Disease Geoffrey C. Nguyen*, Thomas LaVeist, Lisa W. Datta, Mary L. Harris, Theodore M. Bayless, Themistocles Dassopoulos, Steven R. Brant

S1235

Two New Clinical Assessment Tools for Crohn's Disease Patients: Validation, Sensitivity, and Specificity Mark J. Atkinson*, Remo Panaccione, Scott E. Plevy, Sunanda V. Kane, Douglas C. Wolf, Steven Hass, Sumeet Panjabi

S1236

Rapid Normalisation of C-Reactive Protein (CRP) and Scheduled Therapy Are Associated with Sustained Clinical Benefit to Infliximab Long-Term Fabian Schnitzler*, Herma Fidder, Marc Ferrante, Maja Noman, Gert A. Van Assche, Ilse Hoffman, Severine Vermeire, Paul J. Rutgeerts

S1237

5-Aminosalicylates and Renal Function in Children with Inflammatory Bowel Disease Riccardo Lubrano*, Claudia Raggi, Ilaria Menghi, Giulia Maiella, Giuliana Guido, Paola Falconieri, Osvaldo Borrelli, Salvatore Cucchiara

S1223

Increased Spermine Oxidase Expression in Ulcerative Colitis Shih-Kuang S. Hong*, Rupesh Chaturvedi, David Schwartz, Keith T. Wilson

S1224

Magnifying Endoscopic View and Pit Pattern Diagnosis in Ulcerative Colitis-Associated Dysplasia Ken-ichi Mizuno*, Kazuo Ohtsuka, Kenta Kodama, Shigeharu Hamatani, Shin-ei Kudo

S1225

Fecal Osteoprotegerin: A Marker for Pediatric Ulcerative Colitis At Diagnosis - a Pilot Study Anthony Skinner, Trudy Lerer, Nancy Wyzga, Anuradha Viswanathan, Francisco Sylvester*

S1226

Extension and Activity of Ulcerative Colitis: EndoscopicHistopathologic Correlation Maria Rosa Ortiz, Ferran Gonzalez-Huix*, Manuel Adrados, Montserrat Figa, Esther Diaz, Graciela Barraza, Lluis Bernadó

MAY 18

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

THERAPEUTIC MONITORING Participants will be able to: • Review recent research related to therapeutic monitoring. S1227

The Changes of Fecal Microbiota in Patients with Crohn's Disease During Elemental Diet Hisashi Shiga*, Takayuki Kajiura, Sho Takagi, Yoshitaka Kinouchi, Seiichi Takahashi, Kenichi Negoro, Eiki Nomura, Hiroshi Yokoyama, Manabu Suzuki, Junko Shinozaki, Tooru Shimosegawa

S1238

Levels of 6-Thioguanine Nucleotides Following Oral and Intravenous Administration of Relatively Low-Dosed 6TG (0,3 mg/kg) in IBD-Patients Bindia Jharap*, Nanne de Boer, René M. Vos, Godefridus J. Peters, Bram Wilhelm, Chris J. Mulder, Ad A. van Bodegraven

S1228

mesalamine Does Not Impact On Thiopurine-MethylTransferase (TPMT) Activity in Inflammatory Bowel Disease (IBD) Patients Marco Daperno*, Raffaello Sostegni, Roberto Canaparo, Annalisa Vernetto, Loredana Serpe, Ilenia Blanco, Cristiana Barbera, Sergio D'Antico, Angelo Pera, Gian Paolo Zara, Rodolfo Rocca

S1239

Monitoring Azathioprine (AZA) Treatment in Inflammatory Bowel Disease (IBD): Rituals RE-Visited But Not Revised! Margaret Walsh, Christine Royston, M. Srinivas, Barbara Hoeroldt, Pierre J. Willemse, Pandurangan Basumani, Karna Dev Bardhan*

S1240

Azathioprine (AZA) and Mercaptopurine (MP)-Induced Myelotoxicity in Patients with Inflammatory Bowel Disease (IBD): A Systematic Review Javier P. Gisbert*, Fernando Gomollon

P-148

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL S1241

S1242

Safety Profile of Infliximab in Children with Inflammatory Bowel Disease (IBD): Pediatric Italian Registry of the Biological Therapy for IBD. Multicenter Study of the Italian Society for Pediatric Gastroenterology Hepatology and Nutrition (SIGENP) Franca Viola, Massimiliano Paganelli, Alberto Ravelli, Paolo Lionetti, Arrigo Barabino, Giuliano Lombardi, Graziella Guariso, Michele Cicala, Vincenzo Rutigliano, Paolo Diaferia, Salvatore Accomando, Carlo Catassi, Salvatore Cucchiara* Through-the-Scope Dilation in Stenotic Crohn's Disease: Results of a Large Cohort of Consecutive Patients Vera Kessler Brondolo*, Janek Binek, Christian Felley, Christina A. Knellwolf, Jan Borovicka, Paul H. Wiesel, Gian Dorta, Christa Meyenberger, Pierre F. Michetti

S1243

Practice Patterns of 5-ASA Use in Ulcerative Colitis (UC): Results of a National Vignette Survey Comparing Experts vs. Community Providers Brennan M. Spiegel*, Wayne Ho, Eric Esrailian, Gil Y. Melmed, Peter D. Higgins, Corey A. Siegel, Marla C. Dubinsky, Stephan R. Targan

S1244

High Level of Adherence to Therapy in Dutch Patients with Inflammatory Bowel Disease Judith E. Baars*, Zuzana Zelinkova, Peter B. Mensink, Tineke Markus, E. J. Kuipers, Christien J. van der Woude

S1245

Mucosal Healing in Ulcerative Colitis Patients in LongTerm Therapy with Infliximab Alfredo Papa*, Italo De Vitis, Luisa Guidi, Fabio Aiello, Giovanni Brandimarte, Walter Elisei, Simona Guglielmo, Giammarco Mocci, Italia Roberto, Michele Bonizzi, Sara Ennas, Carla Felice, Gianluca Andrisani, Antonio Gasbarrini, Giuseppe Fedeli

S1246

Long Term Safety and Efficacy of Allopurinol and Azathioprine or 6-Mercaptopurine in Patients with Inflammatory Bowel Disease Yvette Leung*, Miles Sparrow, Stephen B. Hanauer

S1247

Can We Predict Highly Frequent Myelotoxicity During Azathioprine/6-Mercaptopurine Treatment in Korean Patients with Inflammatory Bowel Disease By Thiopurine Methyltransferase Genotyping and Phenotyping or Inosine Triphosphate Pyrophosphatase Genotyping?: A Multicenter Study Jae Hak Kim*, Jae Hee Cheon, Seong Soo Hong, Chang Soo Eun, Jeong-Sik Byeon, Sung Yi Hong, Bo-Young Kim, Soon-ho Kwon, Dong Soo Han, Suk-Kyun Yang, Won Ho Kim

S1248

S1249

The Relationship Between Azathioprine/6Mercaptoputine Dose and 6-Thioguanine Nucleotide Levels in Children with Inflammatory Bowel Diseases Yoram Bujanover*, Arie Levine, Reuven Bromberg, Akiva Fradkin, Batya Weiss Dervieux's Modified Dosage Method Doesn't Come Out with a Therapeutic Efficacy Threshold of the 6 Tioguanine-Nucleotides (6-TGN) in Inflammatory Bowel Disease (IBD) Xavier Roblin*, Jean Marc Phelip

S1250

Utility of Azathioprine Metabolites Determination During Follow Up of Inflammatory Bowel Disease Patients After Steroid Treatment Withdrawal Yago Gonzalez-Lama

S1251

6-Thioguanine Nucleotide (6-TGN) Concentrations and Efficacy of Azathioprine (AZA) and Mercaptopurine (MP) in Inflammatory Bowel Disease: The Metaza Study Javier P. Gisbert



AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Intestinal Disorders

CELIAC DISEASE: CLINICAL ADVANCES I Participants will be able to: • Evaluate clinical advances in celiac disease. S1252



Presentation and Long Term Follow-Up of Refractory Celiac Disease (RCD): Comparison of Rcd of Type I with Rcd of Type II Georgia Malamut*, Pauline Afchain, Thierry Lecomte, Dominique Cazals-Hatem, Virginie Verkarre, Diane Damotte, Yoram Bouhnik, Jean-Frédéric Colombel, JeanCharles Delchier, Matthieu Allez, Jacques Cosnes, Anne Lavergne-Slove, Elizabeth Macintyre, Bertrand Meresse, Olivier Hermine, Nicole Brousse, Nadine Cerf-Bensussan, Christophe Cellier

S1253

Age At Gluten Introduction and Risk of Celiac Disease (CD): A Prospective, Multicentre, Nutritional Intervention Study On Infants At Family CD Risk Carlo Catassi*, Elisabetta Fabiani, Letizia Saturni, Ruggiero Francavilla, Stefania Castellaneta, Aniballi Francesca, Elena Lionetti, Debby Kryszak, Swati Kolpuru, Alessio Fasano

S1254

Anti-Tissue Transglutaminase Antibodies and Infectious Diseases in Children Serena Pastore, Sara Quaglia, Fortunato Ferrara, Stefano Martelossi, Alessandro Ventura, Tarcisio Not*

S1255

Usefulness of Mass Screening for Gluten Sensitive Enteropathy (GSE) in a Working Healthy Population Meritxell Mariné*, Maria Esteve, Montserrat Alsina, Carme Farré, Antonio Salas, Fernando Fernández-Bañares, Merce Rosinach, Rebeca Santaolalla, Clarisa Gonzalez, Josep Maria Viver

S1256

Haptoglobin Polymorphism: A Novel Genetic Risk Factor for Celiac Disease Development and Its Clinical Manifestations Maria Papp*, Ildiko Foldi, Eva Nemes, Miklos Udvardy, Jolan Harsfalvi, Istvan Altorjay, Istvan Mate, Tamas Dinya, Gabor Veres, Peter Laszlo Lakatos, Ilma Rita KorponaySzabo

S1257

Anti-Glycan Antibodies in Celiac Disease Before and After Gluten-Free Diet Maria Papp*, Tamas Dinya, Ildiko Foldi, Nir Dotan, Ilma Rita Korponay-Szabo, Eva Nemes, Gabor Veres, Istvan Altorjay, Peter L. Lakatos

S1258

What Are the Implications of Newly Identified Celiac Disease in Patients with Type 1 Diabetes Mellitus? Effect Upon Glycaemic Control, Quality of Life, Cardiac Risk Factors and Peripheral Nerve Function John S. Leeds*, Marios Hadjivassiliou, Solomon Tesfaye, David S. Sanders

S1259

Intestinal Deposits of IgA Anti-Tissue Transglutaminase Antibodies in Children with Potential Coeliac Disease Antonella Tosco*, Maria Maglio, Renata Auricchio, Francesco Paparo, Anna Sannino, Viviana Granata, Barbara Colicchio, Luciano Rapacciuolo, Riccardo Troncone

S1260

The Management of Coeliac Disease and Its Complications: A European Coeliac Specialists Experience Neil Rajoriya*, Nishchay Chandra, Chris J. Mulder, Antony Ellis

Denotes DDW Poster of Distinction

P-149

S U N D A Y MAY 18

POSTER SESSIONS—CLINICAL S1261

Serology Testing for Antibodies in Celiac Disease: Comparison of Multiplex Immunoassay and ELISA Methods Shadi Rashtak*, Michael W. Ettore, Henry A. Homburger, Joseph a. Murray

S1271

Comparison of Colonic Transit Time Between Patients with Constipation Predominant IBS and Functional Constipation; a Case-Control Study Reza Ansari, Sahand Sohrabi*, Hiva Amjadi, Omid Ghanaei, Shahin Merat, Homayoun Vahedi, Reza Malekzadeh

S1262

Serology of Celiac Disease in Gluten Sensitive Ataxia or Neuropathy Shadi Rashtak*, Melissa R. Snyder, Henry A. Homburger, Sean J. Pittock, Joseph a. Murray

S1272

S1263

Implications of Enzymatic Detoxification of Food Gluten in Coeliac Disease Peter Watson*, Alvin Ding, Stanley A. McMillan, Mike Smye, Elizabeth McClean, Heather Lawther, Claire Gallagher, Tina Riedel, Harmit Vora, J. Gass, Chaitan Khosla, Gary M. Gray

Lubiprostone Is Effective and Well Tolerated Through 48 Weeks of Treatment in Adults with Irritable Bowel Syndrome and Constipation William D. Chey*, Douglas A. Drossman, Charles Scott, Raymond M. Panas, Ryuji Ueno

S1273

Standard Admission Lab Values As Predictors of Outcome in Patients with Colon Ischemia (CI), Crohn's Disease (CD), and Clostridium difficile Associated Disease (CDAD) Paul Feuerstadt*, Olga C. Aroniadis, Lawrence J. Brandt

S1264

The Lazy Celiac Adults and Their Bone Density Cristina Bucci, Paola Iovino, Raffaella Tortora, Fabiana Zingone, Maria Domenica Franzese, Carmela Cappello, Valentina Passananti, Carolina Ciacci*

S1274

Bacterial Overgrowth and Mucosal Inflammation in Irritable Bowel Syndrome Ross N. Butler*, Lauren V. Garritt, Stamatiki Kritas, Geoff Davidson

S1265

Evaluation of a Whole Blood-Based Rapid Test for IgA Anti-Transglutaminase Detection in Celiac Disease Luc de Chaisemartin*, Georgia Malamut, Christophe Cellier, Marie-Agnès Dragon-Durey

S1275

Intestinal Ischemia Due to Sodium Polystyrene Sulfonate (Kayexalate) in Sorbitol: Not Just in the Very Ill Christopher E. McGowan*, Sumona Saha, Grant Chu, Murray B. Resnick, Steven F. Moss

S1276

In Patients with Severe Constipation, Can We Predict Delayed Colonic Transit On the Basis of Symptoms? Philip G. Dinning*, Mike Jones, Sergio E. Fuentealba, Nicholas J. Talley, Ian J. Cook

S1277

Lactulose Versus Plantago Ovata in the Treatment of Haemorrhoids and/or Anal Fissure: Open Randomized Parallel Multicenter Study Monica Perona*, Fermin Mearin, Rafael Campo, Ines Modolell, Miguel Montoro, Enrique Dominguez-Munoz

S1278

Endoscopic Management of Chronic Radiation Proctitis An Audit of 6 Years Experience At a Single Institution Michael Swan*, David Devonshire, William Sievert

S1279

Brazilian Prevalence of Irritable Bowel Syndrome: A Population-Based Study Guilherme B. Sander, Carlos F. Francesconi*, Luiz E. Mazzoleni, Maria Helena I. Lopes, Julio C. Madi

S1280

Role of Multi-Detector Row Computed Tomography (MDCT) for Localization of Acute Lower Gastrointestinal Bleeding Tae Oh Kim, Sun Mi Lee*, Hyoung Yoel Park, Kyung Yeob Kim, Jae Sup Eum, Gwang Ha Kim, Dae Hwan Kang, Geun-Am Song

AGA Institute Poster Session 8:00 AM - 5:00 PM

S U N D A Y MAY 18

Sails Pavilion San Diego Convention Center

Sponsored by: Intestinal Disorders

CLINICAL INTESTINAL DISORDERS I Participants will be able to: • Familiarize themselves with recent clinical intestinal disorders research findings and implications. S1266



Correlation Between C-Reactive Protein and b2Microglobulin with Histologic Disease Activity in Ulcerative Colitis(UC) Jesus A. Camacho-Escobedo*, Felix Tellez-Avila, Josué Barahona-Garrido, Jesus K. Yamamoto-Furusho

S1267



Recurrence and Long-Term Evolution of Transmural and Luminal Small Bowel Lesions After Curative Ileal Resection in Crohn's Disease (CD) Patients Nadia Pallotta*, Naima Abdulkadir Hassan, Chiara Montesani, Piero Chirletti, Anna Maria Pronio, Fausto Barberani, Giuseppina Vincoli, Maurizio Giovannone, Alessandro Gigliozzi, Mauro Di Camillo, Mauro Tosoni, Enrico Corazziari

S1268



Digestive Symptoms in Mastocytosis Harry Sokol*, Danielle Canioni, Nadia Hoyeau, Stephane Barete, Olivier Lortholary, Olivier Hermine

S1269

Small Intestinal Bacterial Overgrowth in a Children Population Affected By Irritable Bowel Syndrome: A Case-Control Study E. Scarpellini*, C. Fundarò, V. Giorgio, A. Pantanella, V. Cesario, Ernesto Cristiano Lauritano, Davide Roccarina, Marialuisa Novi, M. Ainora, M. Garcovich, Giovanni Gigante, Giovanni Cammarota, Giovanni Gasbarrini, Giovanni Ghirlanda, Antonio Gasbarrini

 S1270

P-150

Plasma Adiponectin Levels in Patients with Infliximab Treatment for Steroid-Refractory Gastrointestinal Acute Graft-Versus-Host Disease Yoko Murayama*, Shusaku Tsutsui, Yasuhisa Shinomura, Norio Hayashi

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Intestinal Disorders

INTESTINAL INFLAMMATION, INJURY AND REPAIR I Participants will be able to: • Review recent research in intestinal inflammation, injury and repair. S1281



Investigation of the Regenerative Mechanism of Colonic Mucosa in Reg I-Alpha Knockout Mice Masakatsu Fukuzawa*, Fuminori Moriyasu

S1282

Curcumin Inhibits Angiogenesis of Human Intestinal Microvascular Endothelial Cells (HIMEC) Through COX-2 Inhibition Parvaneh Rafiee*, Mary F. Otterson, David G. Binion



Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL S1283

Hyaluronan Inhibits Dextran Sodium Sulfate-Induced Colitis in a Toll-Like Receptor Dependent Manner Ling Zheng*, Yan Zhang, Terrence Riehl, William Stenson

S1284

An Essential Role of 5-HT in Pathogenesis of Experimental Colitis Jean-Eric Ghia*, Huaqing Wang, Yikang Deng, Nan Li, Rami T. El-Sharkawy, Francine Côté, Jacques J. Mallet, Waliul I. Khan

S1285

Blockade of NK-1 Receptors Protects Jejunal Mucosa in NSAID- Related Injury Ryszard Sendur*, Jaroslaw Biernat, Teresa Pawlik, Artur Dembinski, Wieslaw W. Pawlik

S1286

Mesalamine Restores Angiogenic Balance in Experimental Ulcerative Colitis By Reducing Expression of Endostatin and Angiostatin: Novel Molecular Mechanism for mesalamine's Therapeutic Action Xiaoming Deng*, Ganna Tolstanova, Tetyana Khomenko, Longchuan Chen, Ximing Xiong, Andrzej Tarnawski, Sandor Szabo, Zsuzsa Sandor

S1287

S1288

Toll-Like Receptor 4 (TLR4) Differentially Regulates Epidermal Growth Factor (EGF)-Related Growth Factors in Response to Acute Intestinal Mucosal Injury David Hsu*, Masayuki Fukata, Anli Chen, Yasmin Hernandez, Ryan Ungaro, Tyralee Goo, Keith J. Breglio, Maria T. Abreu Intestinal Epithelial Cell-Specific Overexpression of Prohibitin (PHB) Ameliorates Experimental Colitis in Mice Arianne L. Theiss*, Tracy S. Obertone, Didier Merlin, Shanthi V. Sitaraman

S1289

Treatment of Induced Colitis in Mice By the RAS Antagonist Farnesylthiosalicylic Acid (FTS) Shimon Reif

S1290

NF-κB-Dependent Gene Transcription in Response to Lipopolysaccharide Is Delayed and Prolonged in the Neonatal Intestine Runlan Tian*, Shirley X. Liu, Isabelle G. De Plaen

S1291

S1292

S1293

S1294

S1295

Roles of Endogenous Prostaglandins/EP4 Receptors in Development and Healing of Indomethacin-Induced Small Intestinal Lesions in Rats: Relation to MUC, iNOS and VEGF Expressions Mayu Tanigami*, Michitaka Ogura, Kazuhiko Nagao, Akimu Ochi, Kikuko Amagase, Koji Takeuchi MMP9 Mediated Tissue Injury Overrides the Protective Effect of MMP2 On the Development of Colitis Pallavi Garg*, Matam Vijay-Kumar, Lixin Wang, Anupama Ravi, Andrew T. Gewirtz, Didier Merlin, Shanthi V. Sitaraman Is There a Role for Adipocytokines On the Effect of Anti-TNF Treatment in An Experimental Model of Colitis? Suna Yapali*, Mustafa Deniz, Fatih Eren, Nese Imeryuz, Cigdem Celikel, Naziye Ozkan, Veysel Tahan, Hulya O. Hamzaoglu, Nurdan Tozun Role of Corticotropin-Releasing Factors in Pathogenesis of NSAID-Induced Small Intestinal Lesions in Rats Yoshikazu Kubo*, Michitaka Ogura, Aiko Kumano, Shinichi Kato, Koji Takeuchi Detrimental Role of Endothelial Nitric Oxide Synthase (eNOS/NOS3) in Aggravation of Indomethacin-Induced Gastric Damage in Adjuvant Arthritis Rats Shinichi Kato*, Yasuyuki Ito, Fumikazu Ohkawa, Kikuko Amagase, Koji Takeuchi

S1296

A2b Adenosine Receptor Gene Deletion or Antagonism Attenuates Murine Colitis Vasantha L. Kolachala*, Matam Vijay-Kumar, Lixin Wang, Dan Yang, Melissa Marshall, Guoquan Wang, Joel Linden, Andrew T. Gewirtz, Didier Merlin, Katya Ravid, Shanthi V. Sitaraman

S1297

Role of IL-4 and IL-1β On the Pathogenesis of 5Fluorouracil (5-FU) Induced Intestinal Inflammation in Mice Pedro Marcos G. Soares, José Maurício S. Mota, Gerly Anne C. Brito, Fernando Q. Cunha, Ronaldo A. Ribeiro, Marcellus H. Souza*

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Liver & Biliary

PORTAL HYPERTENSION AND VASCULAR DISEASES OF THE LIVER Participants will be able to: • Understand new changes in the management of portal hypertension; and • Learn about vascular diseases of the liver. S1298

Hemodynamics in the Gastrorenal Shunt On Doppler Ultrasound Reflect the Grading and Bleeding of Gastric Fundal Varices Hitoshi Maruyama*, Hidehiro Okugawa, Osamu Yokosuka

S1299

Low-Dose Phosphodiesterase-5-Inhibitors Have a Distinct Effect On Hepatic Hemodynamics Leonie Halverscheid*, Peter Deibert, Torsten Dunkern, Rene Schmidt, Benedikt H. Pannen, Wolfgang Kreisel

S1300

Noninvasive Variceal Pressure Measurement Using Endoscopic Air Insufflation and Transendoscopic Manometry Anil K. Vegesna, Chan Y. Chung*, Amit Kalra, Anurag Bajaj, Imran Hamid, Mansoor I. Tiwana, Ranjitha Rishikesh, Sapna Patel, Annapurna Korimilli, Larry S. Miller

S1301

A Model for Non-Invasive Measurement of Intra-Variceal Pressure Using Simultaneous Endoscopy with Air Insufflation and Manometry Anil K. Vegesna*, Imran Hamid, Anurag Bajaj, Aamir Raza, Mamoon Rasheed, Jehanzeb Riaz, Mansoor I. Tiwana, Chan Y. Chung, Annapurna Korimilli, Larry S. Miller

S1302

The Safety of Transjugular Intrahepatic Portosystemic Shunt Placement in Patients with Elevated Right Ventricular Systolic Pressure On Echocardiogram Amit Bhatt*, William D. Carey, Thomas A. Brown, Raed A. Dweik, Rocio Lopez

S1303

Diagnosis of Portal Vein Thrombosis with Contrast Ultrasonography Using Maximum Intensity Projection Technique, Micro Flow Imaging (MFI) Shigeki Ichimura*, Yoshihiro Furuichi, Ryo Metoki, Katsutoshi Sugimoto, Junichi Taira, Masahiko Yamada, Yasuharu Imai, Ikuo Nakamura, Fuminori Moriyasu

S1304

Three-dimensional CT (3D-CT) Following Contrast Medium Injection Via a Peripheral Vein of the Lower Limb Improves Diagnostic Capability of Budd-Chiari Syndrome Ryo Metoki*, Yoshihiro Furuichi, Shigeki Ichimura, Takatomo Sano, Eigaku Murashima, Junichi Taira, Katsutoshi Sugimoto, Kyosuke Yanagisawa, Masahiko Yamada, Yasuharu Imai, Ikuo Nakamura, Fuminori Moriyasu

Denotes DDW Poster of Distinction

P-151

S U N D A Y MAY 18

POSTER SESSIONS—CLINICAL S1305

Influence of the Portal Pressure Gradient After TIPS in Patients with Liver Cirrhosis - Single Center Experience with 60 Patients Tobias Meister*, Hauke Heinzow, Frank M. Reinecke, Hansjoerg Ullerich, Matthias Koehler, Wolfram W. Domschke, Dirk Domagk

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

S1325

Seronegative Autoimmune Pancreatitis - a Commonly Missed Diagnosis in U.S. Patients? Franklin Kasmin*, Avram Cooperman, Seth A. Cohen, Michael Wayne, William H. Brown, Jerome H. Siegel

S1326

Should Autoimmune Pancreatitis Be Classified Separately from Chronic Pancreatitis? Terumi Kamisawa*, Naoto Egawa, Kouji Tsuruta, Atsutake Okamoto

S1328

Autoimmune Pancreatitis in Young Patients Mitsuho Imai*, Terumi Kamisawa, Yuyang Tu, Naoto Egawa, Kouji Tsuruta, Atsutake Okamoto

Sponsored by: Pancreatic Disorders

CLINICAL CHRONIC PANCREATITIS: AUTOIMMUNE PANCREATITIS Participants will be able to: • Understand the clinical presentation and management of an emerging pancreatic disorder. S1306

S U N D A Y MAY 18

Diagnostic Utility of Biopsy Specimens for Autoimmune Pancreatitis Kenji Hirano*, Noriyoshi Fukushima, Minoru Tada, Hiroyuki Isayama, Yoko Yashima, Hiroshi Yagioka, Takashi Sasaki, Hirofumi Kogure, Osamu Togawa, Toshihiko Arizumi, Saburo Matsubara, Yousuke Nakai, Naoki Sasahira, Takeshi Tsujino, Takao Kawabe, Masashi Fukayama, Masao Omata

S1308



Clinical Analysisi of Regulatory T Cells in Patients with Autoimmune Pancreatitis Hideaki Miyoshi*, Kazushige Uchida, Kazuichi Okazaki

S1309

Vitamin D Deficiency and Low Bone Density Are Common in Patients with Chronic Pancreatitis Joseph Murphy*, Suzanne M. Egan, Kevin C. Conlon

S1310



Clinical Role of FDG-PET in Autoimmune Chronic Pancreatitis Tae Yoon Lee*, Myung-Hwan Kim, Ji Young Kim, Sang Soo Lee, Dong Wan Seo, Sung Koo Lee, Kyu Taek Lee

S1312

Ultrasonographic Imaging of Bile Duct Lesions in Autoimmune Pancreatitis Rikako Koyama*, Yuko Koizumi, Tsunao Imamura, Chikao Okuda, Kazuo Takeuchi

S1315

Immunohistochemical Staining of the Pancreas with TGF-β1, MMP-2 and TIMP-2 in Patients with Autoimmune Chronic Pancreatitis and Alcoholic Chronic Pancreatitis Eun Kwang Choi*, Myung-Hwan Kim, Byung Cheol Song, Heung Up Kim, Sang Soo Lee, Sung Koo Lee

S1317

Long Term Follow-Up of Autoimmune Pancreatitis in Italy Luca Frulloni*, Chiara Scattolini, Giuseppe Zamboni, Sylvain Manfredi, Antonio Amodio, Fosca de Iorio, Luigi Benini, Italo Vantini

S1319

Comparison Between Biliary Lesions Associated with Autoimmune Pancreatitis and Primary Sclerosing Cholangitis Terumi Kamisawa*, Naoto Egawa, Kouji Tsuruta, Atsutake Okamoto

S1321

Appropriate Steroid Therapy for Autoimmune Pancreatitis Based On Long-Term Outcome Terumi Kamisawa*, Tokio Wakabayashi, Hiroyuki Watanabe

S1322

Autoimmune Pancreatitis: Application of Current Diagnostic Criteria Are Suboptimal Samuel A. Giday*, Jonathan M. Buscaglia, Devi Mukkai Krishnamurty, Terina Chen, Anthony N. Kalloo, Marcia I. Canto, Sergey V. Kantsevoy, Patrick Okolo, Ralph H. Hruban, Sanjay B. Jagannath

P-152

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Pancreatic Disorders

CLINICAL CHRONIC PANCREATITIS: MANAGEMENT AND OUTCOMES Participants will be able to: • Understand new developments in diagnosis and management of chronic pancreatitis. S1307



There Is a High Prevalence and Association of Osteopenia in Chronic Pancreatitis(CP) Patients Referred for Dexa Scan Darwin Conwell*, April S. Tignor, Kathryn Repas, Bechien U. Wu, Meryl Leboff, Peter A. Banks

S1311



The Relationship Between Exocrine Pancreatic Hypofunction and Patients Fulfilling the ROME II Criteria for Irritable Bowel Syndrome (Diarrhea Predominant, D-IBS): A Prevalence Study with Controls and Therapeutic Outcomes John S. Leeds*, Andrew D. Hopper, Stephen Morley, David P. Hurlstone, David S. Sanders

S1313



Chronic Pancreatitis and Patient Healthcare Experience: Results of a Multicenter Study Timothy B. Gardner*, Abigail T. Kennedy, Andres Gelrud, Mayar Al Mohajer, Mary Krotchen, Peter A. Banks, Santhi Swaroop Vege, Brian E. Lacy

S1314

Chronic Pancreatitis Characterized By Constant Pain Regardless of Severity Is Associated with Poorer Quality of Life, Lower Functioning and Increased Utilization of Resources Daniel K. Mullady*, David C. Whitcomb, Dhiraj Yadav, Michael M. Barmada, Michael R. O'Connell, Meredith L. Korneffel, Beth M. Weinman, Stephen T. Amann, Michelle A. Anderson, Adam Slivka, Robert H. Hawes, Randall Brand, Mary E. Money, Peter A. Banks, Michele D. Bishop, John Baillie, Stuart Sherman, James A. DiSario, Frank R. Burton, Timothy B. Gardner, Andres Gelrud, Simon K. Lo, Mark T. DeMeo, William Steinberg, Michael L. Kochman

S1316

Comparative Study of Quality of Life in Patients On Long-Term Anti-Oxidant (Antox) Therapy for Painful Chronic Pancreatitis Nehal Shah*, Aali J. Sheen, Ajith K. Siriwardena

S1318

How Does Patient's Self-Reported Alcohol Use Compare with Physician's Assessment in Chronic Pancreatitis (CP)? Dhiraj Yadav*, David C. Whitcomb, Albert B. Lowenfels, NAPS2 consortium For the, Adam Slivka, Robert H. Hawes, Randall Brand, Michelle A. Anderson, Mary E. Money, Peter A. Banks, Michele D. Bishop, John Baillie, Stuart Sherman, James A. DiSario, Frank R. Burton, Timothy B. Gardner, Stephen T. Amann, Andres Gelrud, Simon K. Lo, Mark T. DeMeo, William Steinberg, Michael L. Kochman, Babak Etemad, Chris Forsmark

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL S1320

Alcohol and Smoking Are Independent Predictors for Chronic Pancreatitis Dhiraj Yadav*, Michael M. Barmada, Michele D. Bishop, Michael R. O'Connell, David C. Whitcomb, NAPS2 consortium For the, Adam Slivka, Robert H. Hawes, Randall Brand, Michelle A. Anderson, Peter A. Banks, John Baillie, Stuart Sherman, James A. DiSario, Frank R. Burton, Timothy B. Gardner, Stephen T. Amann, Mary E. Money, Andres Gelrud, Simon K. Lo, Mark DeMeo, William Steinberg, Michael L. Kochman, Babak Etemad, Chris Forsmark

S1323

Onset and Progression of Chronic Pancreatitis: It Is Not Just Alcohol, But Tobacco Maria Luaces, Julio Iglesias-Garcia, Jose Larino-Noia, Ana Alvarez-Castro, Antonio Lozano-Leon, Enrique DominguezMunoz*

S1324

Serial Stricture Dilation Without Pancreatic Stenting Is a Safe and Effective Therapeutic Strategy for the Management of Chronic Pancreatitis-Associated Pancreatic Duct Strictures Elmer Y. Chang*, Karen C. Bagatelos, James L. Buxbaum, Henry K. Niho, James W. Ostroff

S1327

A Dilated Pancreatic Duct Seen On Pre-Operative ERCP Predicts Poorer Post-Operative Quality of Life After Total Pancreatectomy with Autologous Islet Cell Transplantation for Chronic Pancreatitis Richard S. Song, Rajalakshmi R. Nair, Horacio L. Rilo, Syed A. Ahmad, Laura E. James, Nathan Schmulewitz, Shailendra S. Chauhan, Andres Gelrud*

S1329

S1330

S1331

S1332

S1333

S1334

“Bull's Eye” Calculi in Chronic Pancreatitis Associated with Gene Mutations Luca Frulloni*, Chiara Scattolini, Rossella Graziani, Calogero Cicero, Paolo Bovo, Antonio Amodio, Roberto Pozzi Mucelli, Italo Vantini A New Noninvasive Method of Assessing Pancreatic Exocrine Function By a Breath Test in Patients with Chronic Pancreatitis Michiaki Takii*, Yoshifumi Arisaka, Daisuke Masuda, Kazuhide Higuchi Current Profile of Chronic Pancreatitis (CP) in the USA: Is It a Multifactorial Disease? Dhiraj Yadav*, Peter A. Banks, Adam Slivka, David C. Whitcomb, NAPS2 consortium For the Efficacy of Endoscopic Ultrasound (EUS) Guided Celiac Plexus Block (CPB) for Managing Abdominal Pain Associated with Chronic Pancreatitis (CP): A MetaAnalysis Marina S. Kaufman, Gurpreet Singh, Sourish Das, Jonathan A. Erber*, Carlos Micames, Bogdan Cristescu, Frank G. Gress Efficacy and Safety of Ultrase® MT20 in Treating Pancreatic Insufficiency in Cystic Fibrosis Michael W. Konstan*, Theodore G. Liou, Steven Strausbaugh, Richard C. Ahrens, Jamshed F. Kanga, Gavin R. Graff, Kathryn S. Moffett, Susan Millard, Samya Z. Nasr, Manon Vezina, Jean Spénard, Josée Grondin Defining Distal Intestinal Obstruction Syndrome (DIOS) and Constipation in Cystic Fibrosis: A Multicenter Study On the Incidence, Characteristics and Treatment of DIOS Roderick Houwen, Hubert van der Doef, Isabelle Sermet, Anne Munck, Bruno Hauser, Jaroslaw Walkowiak, Eddy Robberecht, Carla Colombo, Maarten Sinaasappel, Michael Wilschanski*

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Nutrition & Obesity

CLINICAL: NUTRITION-MISCELLANEOUS Participants will be able to: • Review novel clinical and basic research in nutrition. S1334a



Glutamine Combined with Arginine Decrease Gut Inflammation in Biopsies from Patients with Active Colonic Crohn's Disease Stéphane Lecleire*, Aktham Hassan, Michel Antonietti, Rachel Marion, Guillaume Savoye, Eric Lerebours, Philippe R. Ducrotté, Pierre M. Déchelotte, Moïse Coëffier

S1334b

The Relationship of Malnutrition with Preoperative Anemia and Blood Transfusions and Their Effect On Postoperative Morbidity and Mortality: More Food for Thought Mohandas K. Mallath*, Mrunal Shirodkar, Yogesh Shastri

S1334c

Lifestyle of Patients with Self-Reported Food Hypersensitivity Differs Little from Controls Ragna Lind, Snorri Olafsson*, Ina Hjelland, Arnold Berstad, Gulen Arslan Lied

S1334d



Increased Intestinal Permeability in Malnourished Patients with Liver Cirrhosis Christine Smoliner*, Sabine Buhner, Kristina Norman, Johann Ockenga, Herbert Lochs, Matthias Pirlich

S1334e

How Much Do Gastroenterology Fellows Know About Nutrition? Maitreyi Raman*, Claudio Violato, Sylvain Coderre

S1334f

Is Metabolic Syndrome a Risk Factor for Colonic Diverticula? Atsuo Yamada*, Takafumi Sugimoto, Haruka Kajiwara, Noriyuki Takano, Miki Ohta, Masao Akanuma, Goichi Togo, Keiji Ogura, Yutaka Yamaji, Takao Kawabe, Masao Omata

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Nutrition & Obesity

MEDICAL MANAGEMENT OF OBESITY Participants will be able to: • Review current research on the medical management of obesity. S1334g



Helicobacter pylori Infection Has a Significant Influence On Metabolic Syndrome in the Japanese Male Population Toshiaki Gunji*, Nobuyuki Matsuhashi

S1334h

An Interdisciplinary Weight Management Program Improves Both Cardiovascular Risk Factors and Nonalcoholic Fatty Liver Disease in Obese Patients Astrid Waechtershaeuser*, Loitsch Stefan Marcel, Blumenstein Irina, Brenner Michael, Jürgen Stein

S1334i

Maintenance-Tailored Treatment Improves Long-Term Weight Loss Rona L. Levy*, Shelby Langer, Ericka M. Welsh, Andrew P. Flood, Melanie A. Jaeb, Patricia S. Laqua, Anne Marie Hotop, Emily A. Finch, Robert W. Jeffery

S1334j

Postprandial Response of Ghrelin and PYY in Lean Young Women with Polycystic Ovary Syndrome Krystyna Zwirska-Korczala

Denotes DDW Poster of Distinction

P-153

S U N D A Y MAY 18

POSTER SESSIONS—CLINICAL S1344

The Role of EUS Guidance for NOTES Procedures: Comparative Study of NOTES Alone Versus EUS Guided NOTES for Selected Indications Annette Fritscher-Ravens*, Amir Ghanbari, Erich Kahle, Heiner Niemann, Peter Koehler, Kamini Patel, Peter Milla

S1345

Endoscopic Colon to Colon Anastomosis. a Comparative Study of Different Methods, Their Feasibility and Safety Annette Fritscher-Ravens*, Charles A. Mosse, Amir Ghanbari, Markus P. Ghadimi, Anja Nilges, Peter Koehler, Wolfram Trudo Knoefel

S1346

Separating Vision and Instrument Motion Improves Performance of Endoscopic Surgery Danny V. Martinec, Bin Zheng*, Christy M. Dunst, Lee L. Swanstrom

S1347

Endoscopic Ultrasound for Localizing Safe Alternate Access Sites for NOTES: Initial Experience in a Porcine Model B. Joseph Elmunzer*, Steve J. Schomisch, Joseph A. Trunzo, Benjamin K. Poulose, Michael F. McGee, Ashley L. Faulx, Conor P. Delaney, Jeffrey M. Marks, Jeffrey L. Ponsky, Amitabh Chak

S1348

Novel Endoscopic Techniques Are Effective for Control of Hemorrhage During NOTES Samuel A. Giday*, Ronald J. Wroblewski, Priscilla Magno, Jonathan M. Buscaglia, Eun Ji Shin, Xavier Dray, Jerome Lyn-Sue, Michael R. Marohn, Sergey V. Kantsevoy, Anthony N. Kalloo

S1349

Feasibility of Transgastric and Transcolonic NOTES Peritoneoscopy Combined with Intraperitoneal Endoscopic Ultrasonography Rogier P. Voermans*, Mark I. van Berge Henegouwen, Willem A. Bemelman, Paul Fockens

S1350

Percutaneous Gastric Lifting with Threaded T-Tag to Prevent Gastric Deflation for Endoscopic Full-Thickness Resection (EFTR) Keiichi Ikeda*, Paul Swain, Kazuki Sumiyama, Hisao Tajiri

S1351

NOTES Is Successful for Vertebral Spinal Interventions with Significant Advantages for Anterior Spinal Procedures Priscilla Magno*, Manuel A. Mas, Yamil Rivera, Samuel A. Giday, Jonathan M. Buscaglia, Eun Ji Shin, Sergey V. Kantsevoy, Xavier Dray, Anthony N. Kalloo

S1352

Comparison of Transgastric Access Techniques for Natural Orifice Translumenal Endoscopic Surgery (NOTES) Stefan von Delius*, Sonja Gillen, Emmanouil Doundoulakis, Armin Schneider, Dirk Wilhelm, Adam Fiolka, Stefan Wagenpfeil, Roland M. Schmid, Hubertus Feussner, Alexander Meining

Closure of a Gastric NOTES-Incision: Comparison of the Closure Bursting Pressure Using TAS T-Tag System, Clips and Open Surgical Closure Asghar Azadani*, Henrik Jonsson, Maria Bergström, Per-Ola Park

S1353

Differences in Peritoneal Bacterial Contamination of Natural Orifice Transluminal Endoscopic Surgery (NOTES) vs. Laparoscopy in a Colon Perforation and Repair Model Joseph Romagnuolo*, Katherine A. Morgan, John Morris, Robert H. Hawes, Seth Palesch

A Randomized Comparison of Laparoscopic, Flexible Endoscopic, and Wired and Wireless Magnetic NOTES Cameras On Ex-Vivo and In-Vivo Surgical Performance Daniel J. Scott*, Shou Jiang Tang, Richard Bergs, Christopher O. Olukoga, Juan Paramo, Deborah C. Hogg, Lisa A. Hollett, Raul Fernandez, Jeffrey A. Cadeddu, Paul Swain

S1354

Transesophageal Access to the Mediastinum: Long Term Animal Survival Study Using NOTES Technique Annette Fritscher-Ravens*, Wolfram Trudo Knoefel, Claus F. Eisenberger, Stefan Schiffmann, Axel von Herbay, Markus P. Ghadimi, Anja Nilges, Peter Koehler, Amir Ghanbari

Performance of Experimental Occlusion Balloon in Transcolonic Endoscopic Peritoneoscopy (NOTES) Elena Dubcenco*, Teodor Grantcharov, Catherine Streutker, Ori D. Rotstein, Nancy N. Baxter, Khursheed N. Jeejeebhoy, Jeffrey P. Baker

S1355

Controlled Comparison of Increased Force Transmission Delivered Via Five Novel Endoscope Stiffening Technologies Paul Swain*, Kurt R. Bally, James T. Spivey, Gregory J. Bakos, David Stefanchik

ASGE Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

ENDOSCOPIC TECHNOLOGY S1335

Transvaginal NOTES Placement of An Implantable Vagal Nerve Blocking Device for Morbid Obesity Mehran Anvari*, Margherita Cadeddu, Michael D. Bierk, Satish Ramadhyani, Katherine S. Tweden, Gregory T. Schulte, Paul Swain

S1336

Transgastric Natural Orifice Translumenal Endoscopic Surgery (NOTES) Peritoneoscopy: A Pilot Study in Efficacy and Gastrotomy Site Selection Joseph A. Trunzo*, Michael F. McGee, Raymond P. Onders, Jonathan P. Pearl, Benjamin K. Poulose, Jeffrey L. Ponsky, Jeffrey M. Marks

S1337

S1338

S U N D A Y

S1339

MAY 18 S1340

S1341

S1342

S1343

P-154

NOTES Abdominal Exploration: A Prospective Comparative Study of Laparoscopy, Transgastric NOTES and Transcolonic NOTES in a Porcine Model Sohail N. Shaikh*, Gloria Fernandez-Esparrach, Marvin Ryou, Michele B. Ryan, Patricia Sylla, Arielle J. Cohen, Massimo Ferrigno, David W. Rattner, Christopher C. Thompson NOTES Thoracic Surgery in a Human Cadaveric Model: Transesophageal Exploration of the Mediastinal, Pericardial and Pleural Spaces Followed By Pleural Biopsy, Lymph Node Sampling, Thoracic Duct Ligation, Vagotomy, Thymectomy and Pericardial Window Marvin Ryou*, Sohail N. Shaikh, Gloria FernandezEsparrach, Michele B. Ryan, Dan Maurice, Erica L. Matthes, Markus D. Enderle, Christopher T. Ducko, Christopher C. Thompson Transgastric Ventral Hernia Repair: A Randomized Controlled Study in a Live Porcine Model Sergey V. Kantsevoy*, Xavier Dray, Eun Ji Shin, Jonathan M. Buscaglia, Priscilla Magno, Sheung Chee Sydney Chung, Peter B. Cotton, Christopher J. Gostout, Robert H. Hawes, Anthony N. Kalloo, Pankaj J. Pasricha, Lia R. Assumpcao, Michael R. Marohn, Jay A. Redan, Samuel A. Giday In Vitro Comparison of Seven Gastric Closure Modalities for Natural Orifice Transluminal Endoscopic Surgery (NOTES) Rogier P. Voermans*, Anna Worm, Mark I. van Berge Henegouwen, Paul Breedveld, Willem A. Bemelman, Paul Fockens

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL S1356

Evaluation of Bifurcated Double T-Bar Suturing Device for Effective Closure of Gastric Perforation in ex vivo Porcine Models -Aimed At Clinical Application of NOTESKeiichi Ikeda*, Hisao Tajiri

S1357

The Hydrogen-Based Quantitative Leak Test Is Rapid, Minimally Invasive and Highly Accurate for Closure Assessment After NOTES Procedures Xavier Dray*, Samuel A. Giday, Jonathan M. Buscaglia, Susan K. Redding, Ron J. Wroblewski, Lia R. Assumpcao, Eun Ji Shin, Priscilla Magno, Laurie J. Pipitone, Michael R. Marohn, Anthony N. Kalloo, Sergey V. Kantsevoy

S1370

Linear Stapler Formation of Ileo-Rectal, Entero-Enteral and Gastrojejunal Anastomoses During Dual and Single Access “Pure” NOTES Procedures: Methods, Magnets and Stapler Modifications Paul Swain*, Per-Ola Park, Shou Jiang Tang, Maria Bergström, Richard I. Rothstein, Richard Bergs, Christopher O. Olukoga, Lisa A. Hollett, Raul Fernandez, Jeffrey A. Cadeddu, Daniel J. Scott

S1371

Endoscopic Double-Layer Closure with Mucosal Flap By Combination Use of Tissue Anchors and Metallic Clips -Application of ESD Technique for NOTESKeiichi Ikeda*, Kazuki Sumiyama, Hisao Tajiri

S1358

Technical Aspects and Improvement in Human Transvaginal Cholecystectomy Luca Milone, Marc Bessler*, Dennis L. Fowler, Peter D. Stevens

S1372

Randomized Study Reveals Significant Difference in TNF-A Between NOTES and Laparoscopy Juliane Bingener*, Naveen K. Krishnegowda, Lauren Buck, Kent Van Sickle, Wayne H. Schwesinger, Joel E. Michalek

S1359

Transvaginal Single Access “Pure” NOTES Sleeve Gastrectomy Using a Deployable Magnetically Anchored Video Camera Daniel J. Scott*, Shou Jiang Tang, Richard Bergs, Christopher O. Olukoga, Juan Paramo, Lisa A. Hollett, Deborah C. Hogg, Raul Fernandez, Jeffrey A. Cadeddu

S1373

Omental Gastrotomy Closure - Model for a NOTES Graham Patch Juliane Bingener*, Samer Sbayi, Sandeep Patel

S1374

Investigation for Acceptance of Natural Orifice Translumenal Endoscopic Surgery By Inpatients with Digestive Diseases Wen Li, Jianguo Xiao*

S1375

Randomized Testing Optimizing Parameters for Flexible Endoscopic Suturing in the Stomach Using T-Tag Suture Fasteners Richard I. Rothstein, Heather Bowman, Andrew Zwolinski, Paul Swain*

S1376

Detection of Gastric Leaks in An ex vivo Porcine Model Using Sulfur Hexafluoride (SF6): A Feasibility Study Richard S. Kwon*, Radoslav Coleski, Jonathan F. Finks, Cyrus R. Piraka, Grace H. Elta, James M. Scheiman

S1377

Transgastric Access to Peritoneal Cavity Using Novel One-Step Needle Sphincterotome Philip W. Chiu*, James Y. Lau, Candice C. Lam, Johnson Yip, Joseph J. Sung, Enders K. Ng

S1360

S1361

S1362

The “Elite”: Construct Validation of a New Training System for NOTES Sonja Gillen, Armin Schneider, Adam Fioka, Stefan von Delius, Alexander Meining*, Hubertus Feussner Live Video Manipulator for Endoscopy and NOTES (with Videos) Shou Jiang Tang*, Richard Bergs, Saad F. Jazrawi, Christopher O. Olukoga, Raul Fernandez, Daniel J. Scott Translumenal Intraperitoneal Confocal Laser Endomicroscopy: A Pilot Study in a Porcine Model Sergey V. Kantsevoy*, Ralf Kiesslich, Xavier Dray, Priscilla Magno, Samuel A. Giday, Sanjay B. Jagannath, Jonathan M. Buscaglia, Martin Goetz, Kerry B. Dunbar, Lia R. Assumpcao, Marcia I. Canto

S1363

Mediastinoscopy and Thoracoscopy: A Next NOTES Frontier? Richard I. Rothstein*, Maria Bergström, Per-Ola Park, Alexander C. Mosse, Paul Swain

S1364

Usefulness of a Magnetizing Device for Fixing Multiple Surgical Tools and Organs System in Hybrid Natural Orifice Transluminal Endoscopic Surgery Takeshi Ohdaira*, Keiichi Ikeda, Kazuki Sumiyama, Hisao Tajiri

S1365

NOTES - Flexible Appendectomy in Human Joern Bernhardt*, Kaja Ludwig

S1366

Natural Orifice Transluminal Endoscopic Surgery (NOTES) vs. Laparoscopy for Colon Perforation and Repair: Feasibility and Risk of Adhesions Joseph Romagnuolo*, Katherine A. Morgan, Seth Palesch, Robert H. Hawes, John Morris

S1367

A NOTES Drainage of Two Infected Pseudocysts: Endoscopic Stapled Cystgastrostomy David J. Desilets*, John R. Romanelli, David Earle

S1368

Use of a Purpose-Built NOTES Trocar for Maintaining Inflation Pressures During NOTES Labs in a Porcine Model Maria Bergström*, Per-Ola Park, Gregory J. Bakos, Christie Cunningham, William D. Fox, Robert Trusty, Suzanne Thompson, Paul Swain

S1369

Retraction Force Measurement During Transgastric and Transvaginal NOTES Priya A. Jamidar*, Charles A. Mosse, Margherita Cadeddu, Michael Boyd, Paul Swain

S1378

Efficacy of Novel Endoscopic Gastrototomy Closure Device in Porcine Models Jennifer S. Chennat*, Alberto Herreros de Tejada, Vihar C. Surti, Marek A. Niekrasz, Craig L. Wardrip, Irving Waxman

S1379

New Method of Gastric Incision Closure in NOTES: Short Term Survival Study Emad Y. Rahmani*, Lynetta Freeman, Stuart Sherman, Michael V. Chiorean, Don J. Selzer

S1380

In-Vivo Remote Manipulation of Modified Capsule Endoscopes Using An External Magnetic Field Frank Volke, Jutta Keller, Andreas Schneider, Jeremy Gerber, Meike Reimann-Zawadzki, Elisha Rabinovitz, Charles A. Mosse, Paul Swain*

S1381

Mucosal EGG, Performed Endoscopically, Predicts Response to Temporary and Permanent GES in Gastroparetic Patients Narendra Siddaiah, John M. Runnels, Mark Runnels, Robert Schmieg, J. R. Salameh, William Johnson, Thomas L. Abell*

S1382

Is Capsule Endoscopy Accurate Enough to Screen Cirrhotics for High Risk Varices & Other Lesions? A Blinded Comparison of EGD & PillCam ESO Dennis M. Jensen*, Bhavneet Singh, Disaya Chavalitdhamrong, Thomas O. Kovacs, Martha Carrico, Steven-Huy B. Han, Francisco A. Durazo, Sammy Saab

Denotes DDW Poster of Distinction

P-155

S U N D A Y MAY 18

POSTER SESSIONS—CLINICAL S1383

S1384

S1385

S U N D A Y MAY 18

Can Magnification Narrow-Band Imaging (NBI) Colonoscopy Determine Invasion Depth of Early Colorectal Cancer? - A Prospective Study Masakatsu Fukuzawa*, Satoru Taira, Yutaka Saito, Takahisa Matsuda, Hiroko Hara, Chizuko Manabe, Hiroyuki Tachibana, Fumihiko Yanagisawa, Masaya Nonaka, Yasutaka Hayama, Kenji Yagi, Toshihiro Oshima, Mari Ko, Mikinori Kataoka, Kohei Kawakami, Takao Itoi, Takashi Kawai, Yoshihiro Sakai, Fuminori Moriyasu

S1395

High Definition Colonoscopy (HD+) with I-Scan Function Allows to Recognize and Characterize Flat Neoplastic Changes As Precisely As Chromoendoscopy Arthur Hoffman*, Claudia Kagel, Martin Goetz, Stefan Biesterfeld, Peter R. Galle, Markus F. Neurath, Ralf Kiesslich

S1396

Staging of Colorectal Neoplasia with Confocal Laser Endomicroscopy Using Two Contrast Agents Simultaneously Ralf Kiesslich*, Martin Goetz, Khadija Rafoud, Arthur Hoffman, Michael Vieth, Stefan Biesterfeld, Peter R. Galle, Markus F. Neurath

Diagnostic Advantage of Optical Vs Electronic Magnification for the Diagnosis of Colonic Polyps Adolfo Parra-Blanco*, Takahisa Matsuda, Takahiro Fujii, Yasushi Sano, Juan-Antonio Diaz-Acosta, Juan A. Ortega, David Nicolás-Pérez, Antonio Z. Gimeno-Garcia, Alejandro Jimenez-Sosa, Marta Carrillo-Palau, Enrique Quintero

S1397

Effect of Endoscopic Mucosal Resection (EMR) of Part of the Fundal Mucosa On Plasma Ghrelin Levels in Obese Ossabaw Pigs: Sham Controlled Pilot Study Ayman M. Abdel Aziz*, Emad Y. Rahmani, Mouhamad Alloosh, Michael Sturek, Robert Considine, Angie M. Plummer

Comparison with Narrow Band Imaging (NBI) Magnification and Histology Finding in Colorectal Neoplasms Bong Min Ko*, Moon Sung Lee, Su Jin Hong, Chang Beom Ryu, Jong Ho Moon, Jin-Oh Kim, Joo Young Cho, Joon Seong Lee, Chan Sup Shim, Boo Sung Kim

S1398

In Vitro and Vivo Endoscopic Cellular Imaging of the Muscularis Propria Kazuki Sumiyama*, Hisao Tajiri, Hiroo Imazu, Koji Matsuda, Keiichi Ikeda, Christopher J. Gostout

S1399

A Randomized Crossover Study Comparing Video Endoscopic Autofluorescence Imaging Followed By Narrow Band Imaging with Standard Endoscopy for the Detection of High Risk Lesions in Stomach Jimmy B. So*, Andrea Rajnakova, Manuel Salto-Tellez, Nilesh Shah, Huak Y. Chan, Ming Teh, Khay Guan Yeoh, Noriya Uedo

S1400

A Sequential Approach with Multiple Detection Modalities to Screen Synchronous and Metachronous Esophageal Cancer Using Ultrathin Transnasal Endoscopy Yi-Chia Lee, Jaw-Town Lin*, Ming-Shiang Wu, Han-Mo Chiu, Hsiu-Po Wang

S1386

Pilot for Evaluation of Non-Cardiac Chest Pain in the Emergency Department Setting - Feasibility and Value in the Use of the Esophageal PillCam in Diagnosis of Esophageal Disease in the Acute Setting Mark D. Noar

S1387

Full Screen Digital Image CCD Chip Transnasal Esophagoscopy with Disposable Endosheath (TNE/DE) Is Superior to ESO PillCam (ESO) As Screening Tool for Esophageal Pathology Mark D. Noar

S1388

Efficiency of High Resolution Endoscopy with Acetic Acid Chromoendoscopy for Barrett's Surveillance: Is There Still a Place for Random Biopsies? Juergen Pohl*, Andrea May, Oliver Pech, Christian Ell

S1401

S1389

A Prospective Study Comparing Ultrathin Endoscopy with High-Resolution Endoscopy On Diagnostic Ability for Superficial Gastric Neoplasia and Nonneoplastic Lesions Toyoizumi Hirobumi*, Kaise Mitsuru, Noboru Yoshimura, Jin Yonezawa, Yukinaga Yoshida, Masayuki Kato, Kenichi Goda, Hisao Tajiri, Hiroshi Arakawa

Assessment of the Accuracy of Wireless Capsule Endoscopy in Diagnosing Barrett's Oesophagus Peter Watson*, John S. Collins, Evelyn Warwick, Claire Gallagher, Stephen Hughes, Patricia Flower, Eleanor F. Watson, Suzanne C. Donnelly, Gillian Mulholland, John Morris

S1402

Evaluation of the Villous Pattern By Capsule Endoscopy: Is It Time to Change the Diagnostic Approach to Celiac Disease? Cristiano Spada*, Maria Elena Riccioni, Riccardo Urgesi, Italo De Vitis, Michele Marchese, Pietro Familiari, Andrea Tringali, Paola Fuso, Guido Costamagna

A Novel One-Step Chromoendoscopic Method Using An Aceticacid-Indigocarmine Mixture (Aim) for the Diagnostic Accuracy in Delineating the Margin of Early Gastric Cancers Yoshiro Kawahara*, Ryuta Takenaka, Hiroyuki Okada, Kazuhide Yamamoto

S1403

Routine Choledochoscopy During Endoscopic Retrograde Cholangiopancreatoscopy: Is It Useful? Haimesh Shah*, Arash Nowain, Russell D. Yang

S1404

Efficacy of Total Colonoscopy with and Without a Newly Developed Slit-and-Hole-Type Elastic Hood: A Randomized Prospective Study Shin-ya Abe*, Takuya Inoue, Mitsuyuki Murano, Satoshi Tokioka, Eiji Umegaki, Kazuhide Higuchi

S1405

Is Observation of Vascular Appearance of the Tumor Surface Useful for Diagnosis of the Depth of Early Colorectal Cancer? Kenshi Matsumoto*, Takeshi Terai, Michiro Otaka, Hiroki Mori, Kazuko Beppu, Tomoyoshi Shibuya, Akihiko Kurosawa, Naoto Sakamoto, Taro Osada, Akihito Nagahara, Toshifumi Ohkusa, Tatsuo Ogihara, Sumio Watanabe

S1406

Semiautomatic Computer Analysis of Endomicroscopic Images Can Objectively Predict Malignant Aspect for Upper GI Lesions Razvan Iacob*, Mihaela Onu, Cristian Gheorghe, Mona Dumbrava, Gabriel Becheanu, Corneliu Balan

S1390

S1391

Estimation of Intravascular Pressure (IVPr) and Assessment of Variceal Blood Flow Using a Through-theScope (TTS) Prototype Endoscopic Doppler Ultrasound (DOP-US) Device: A Bench to Bedside Pilot Study Farees T. Farooq*, Michael F. McGee, Wei Xin, Steve J. Schomisch, Jeffrey M. Marks, Richard C. Wong

S1392

Accuracy of Miniprobe Confocal Laser Microscopy for the Detection of Barrett Neoplasia Heiko Pohl*, Thomas Roesch, Michael Vieth, Martin Koch, Valentin Becker, Ahmed C. Khalifa, Alexander Meining

S1393

Efficacy of the New Playback Functions in the Capsule Endoscopy System for Reading Images of Obscure Gastrointestinal Bleeding in Small Bowel Haruhiko Ogata*, Tadakazu Hisamatsu, Susumu Okamoto, Yasushi Iwao, Toshifumi Hibi

S1394

P-156

Efficacy of Narrow Band Imaging Magnification for Microvessel Pattern of Colorectal Lesions Keita Sasajima*, Takao Ohshima, Yukio Saitou, Naomi Uemura

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL S1407

A New Classification of Narrow Band Imaging Magnification Endoscopy (NBI-ME) for Early Gastric Neoplasms (EGN) Before Endoscopic Submucosal Resection (ESD) Chang Beom Ryu*, Hyun Cheol Koo, Young Ji Kim, Ji Heon Kang, Heon Jong Choi, Bong Min Ko, Kye Won Kwon, Su Jin Hong, Jin-Oh Kim, Joo Young Cho, Eun Seok Ko, Joon Seong Lee, Moon Sung Lee, Chan Sup Shim, Boo Sung Kim, Norio Fukami, Yang K. Chen

S1408

Biomarker Expression Associated with Different Patterns Visualized During Narrow Band Imaging (NBI) Endoscopy in Patients with Barrett's Esophagus (BE) Ajay Bansal*, Sharad C. Mathur, Sachin B. Wani, Krishna Pondugula, Amit Rastogi, Prateek Sharma

S1409

Virtual Chromoendoscopy (FICE) and Magnifying Colonoscopy: A Validation Study Adolfo Parra-Blanco*, Alejandro Jimenez-Sosa, Nicolas Gonzalez, David Nicolás-Pérez, Antonio Z. Gimeno-Garcia, Marta Carrillo-Palau, Takahisa Matsuda, Enrique Quintero

S1410

Use of the Fujinon FICE and High Resolution Magnification Endoscopy to Identify Portal Hypertensive Gastropathy Vs Chemical Gastritis Herbert Burgos*, Marcela Porras

S1411

Detection of Metaplastic Columnar Epithelium At the Esophagogastric Junction Using Chromoendoscopy with Alcian Blue Serguei Mouzyka*, Alexandra Fedoseeva

S1412

Full Screen Digital Image CCD Chip Transnasal Esophagoscopy with Disposable Endosheath (TNE/DE) Is Equal to Standard Video Endoscopy As Initial Screening Tool in Chronic GERD Patients Mark D. Noar

S1413

S1414

S1415

S1416

S1417

S1418

Does the Use of High Definition White Light Colonoscopy Leads to Higher Adenoma Detection Rates Compared to Standard Definition White Light Colonoscopy. An Effectiveness Study in 1225 Patients Anna M. Buchner*, Marwan S. Ghabril, Seth A. Gross, Patrick W. Cleveland, Kanwar R. Gill, Anthony Schore, Michael F. Picco, David S. Loeb, John R. Cangemi, Massimo Raimondo, Herbert C. Wolfsen, Timothy A. Woodward, Kenneth R. DeVault, Michael B. Wallace Magnetic Endoscopic Imaging for Routine Colonoscopy Do We Really Need It? Alexander Dechene*, Evelyn J. Maldonado Lopez, Philip A. Hilgard, Joerg F. Schlaak, Susanne Beckebaum, Guido Gerken, Thomas Zoepf The Clinical Utility of High Definition Magnification Endoscopy with and Without Narrow Band Imaging for Detection of Colonic Neoplasia Sally Stipho*, Nooman Gilani, Francisco C. Ramirez Comparison Between High Resolution Colonoscopy, Digital Chromoscopy with or Without Magnification for Detection and Diagnosis of Colorectal Lesions: A Prospective Study Lix A. Reis de Oliveira Trial of Driving Capsule Endoscopy Using a Magnetic Field Eijiro Morita*, Naotake Ohtsuka, Mitsuyuki Murano, Sadaharu Nouda, Ken Kawakami, Kumi Ishida, Yousuke Abe, Takuya Inoue, Naoko Murano, Ken Tosina, Satoshi Tokioka, Yasunori Shindo, Eiji Umegaki, Kazuhide Higuchi Endocytoscopy in the Colorectum Kunihiko Wakamura*, Shin-ei Kudo, Hiroshi Kashida, Nobunao Ikehara, Keita Sasajima, Yasutoshi Kobayashi, Yoshiki Wada, Kenichi Mizuno, Kenta Kodama, Orie Takemura, Noriyuki Ogata, Haruhiro Inoue, Shigeharu Hamatani

S1419

Biophotonic Detection of Increased Microvascular Blood Content (EIBs) As a Marker of Field Carcinogenesis Detection: Potential Adjunctive Technology for Colonoscopy Hemant K. Roy*, Andrew Gomes, Vladimir Turzhitsky, Michael J. Goldberg, Jeremy D. Rogers, Tat-Kin Tsang, Alexey Kromin, Randall Brand, Mohammed Jameel, Nahla Hasabou, Vadim Backman

S1420

Evaluation and Validation of Fuji Intelligent Color Enhancement in Superficial-Type Early Gastric Cancer Shigeto Yoshida*, Ritsuo Mouri, Shinji Tanaka, Yoshito Takemura, Toshiki Yamaguchi, Iwao Kaneko, Madoka Nakao, Daisuke Kamino, Shiro Oka, Toru Hiyama, Yoshitaka Ueno, Masanori Ito, Yasuhiko Kitadai, Masaharu Yoshihara, Kazuaki Chayama

S1421

Interobserver Agreement of a Simplified Classification System of Mucosal Morphology Using Narrow Band Imaging in Barrett's Esophagus; An International MultiCenter Study Lorenza Alvarez Herrero*, Wouter L. Curvers, Ajay Bansal, Sachin B. Wani, Mohammed A. Kara, Ed Schenk, Erik J. Schoon, Christopher R. Lynch, Amit Rastogi, Krishna Pondugula, Bas L. Weusten, Prateek Sharma, Jacques J. Bergman

S1422

Endoluminal MRI of the Pancreas: A Novel Imaging Technology Ashish Nimgaonkar*, Martin P. Smith, Rabindra Kundu, Alexander Ivanishev, Robert E. Lenkinski, Ram Chuttani, James C. Ellsmere

S1423

High-Definition White Light Versus High-Contrast Narrow-Band Imaging™ in the Prediction of Colon Polyp Histology Using Standard Endoscopes: An In-Vivo Study Sanjay Sikka*, Daniel A. Ringold, Sreenivasa S. Jonnalagadda, Gregory S. Sayuk, Bhaskar Banerjee

S1424

Correlation of Fujinon FICE Endoscopic Imaging and Histopathological Findings in Colorectal Adenomas Herbert Burgos*, Marcela Porras

S1425

Unsedated Self-Examination of the Esophagus Using a Tethered-Capsule Endoscope (TCE) Eric J. Seibel*, Charles D. Melville, Richard S. Johnston, Cameron M. Lee, Jason A. Dominitz, Michael B. Kimmey

S1426

Inter and Intra-Observer Variability in the Endoscopic Identification of Barrett's Esophagus with and Without Narrow Band Imaging Hugo Richter, Eduardo Valdivieso, Jaquelina Gobelet*, Claudio Navarrete, Alberto Rodriguez Navarro, Paula Vial, Carlos Aguayo, Maria de los Angeles Gatica, Roque Saenz

S1427

Bile Duct Imaging with Ultrathin Laser Scanning Catheterscope in a Swine Model Eric J. Seibel*, Charles D. Melville, Richard S. Johnston, Cameron M. Lee, Michael D. Saunders, Michael B. Kimmey

S1428

Narrow Band Imaging for Esophageal Surveillance in Patients with Head and Neck Cancers Ryuta Takenaka*, Yoshiro Kawahara, Hiroyuki Okada, Keisuke Hori, Masahide Kita, Takao Tsuzuki, Daisuke Tanioka, Seiji Kawano, Masafumi Inoue, Satoru Yagi, Masayuki Uemura, Shigenobu Nomiya, Tomoo Onoda, Susumu O. Tominaga, Kazuhide Yamamoto

S1429

Infrared Fluorescence Endoscopy Combined with Indocyanine Green Injection for Evaluation of Severity in Patients with Ulcerative Colitis Tetsuo Kimura*, Naoki Muguruma, Toshiya Okahisa, Tatsuzo Itagaki, Hisashi Takeuchi, Masako Kaji, Seisuke Okamura, Tetsuji Takayama

Denotes DDW Poster of Distinction

P-157

S U N D A Y MAY 18

POSTER SESSIONS—CLINICAL S1430

Comparison of Four Methods Using Magnifying Endoscopy for Recognition of the Demarcation in Early Gastric Cancer Kyosuke Tanaka*, Hideki Toyoda, Yasuhiko Hamada, Masaki Katsurahara, Hiroyuki Inoue, Masatoshi Aoki, Ryo Kosaka, Tomohiro Noda, Katsuhito Ninomiya, Tomomi Yamada, Ichiro Imoto, Yoshiyuki Takei

S1431

Endoscopic Auto Fluorescence Imaging Is Useful for Detecting Colonic Small Lesions of Lymphoma Resembling Lymphoid Hyperplasia Nobuhiro Ueno*, Kentaro Moriichi, Katsuya Ikuta, Youkou Konno, Chisato Ishikawa, Takahiro Ito, Ryu Sato, Kotaro Okamoto, Hiroki Tanabe, Atsuo Maemoto, Kazuya Sato, Mikihiro Fujiya, Jiro Watari, Toshifumi Ashida, Yusuke Saitoh, Yutaka Kohgo Endoflag - A New Video Processing Technology Greatly Enhancing Recognition and Characterization of Gastrointestinal Lesions Seen with Standard or High Definition Endoscopes Ralf Kiesslich*, Martin Goetz, Brigitte Schumacher, Erwin M. Santo, Markus F. Neurath, R. Guissin, Zamir Halpern

S1432

S1433

S U N D A Y

Usefulness of Transnasal Endoscopy with FICE for Diagnosis of Recurrent Esophageal Varices Yoshihiro Furuichi*, Takashi Kawai, Shigeki Ichimura, Ryou Metoki, Jyunichi Taira, Katsutoshi Sugimoto, Masahiko Yamada, Yasuharu Imai, Ikuo Nakamura, Fuminori Moriyasu

S1434

Local Heterogeneity of Fluorescence Confocal Endomicroscopy Image Patterns in Ulcerative Colitis (UC)-Associated Dysplasia Finlay A. Macrae*, Prithi S. Bhathal, Wendy J. McLaren, Elise R. Murr, Peter M. Delaney

S1435

Does Sequential Examination of the Colon with White Light Endoscopy (WLE) Followed By Narrow Band Imaging (NBI) Increase the Yield of Dysplasia in Patients with Long Standing Inflammatory Bowel Disease (IBD)? Amit Rastogi*, Sharad C. Mathur, Krishna Pondugula, Sachin B. Wani, Peggy Callahan, Ajay Bansal, John D. Keighley, Prateek Sharma

MAY 18 S1436

Clinical Usefulness of NBI Magnification in Routine Colonoscopic Examination Yuko Hiraga*, Shiro Okamoto, Hideyuki Shima, Kanji Kodama, Shuji Yamaguchi, Naomi Sasaki

S1437

The Intra and Inter Observer Variability of Narrow Band Imaging to Differentiate Hyperplastic Versus Adenomatous Polyps Kandarp Patel*, Francisco C. Ramirez, Richard Gerkin, Nooman Gilani

S1438

A New Method for Entero-Enteral Anastomosis Margherita Cadeddu*, Charles A. Mosse, Priya A. Jamidar, Mehran Anvari, Michael Boyd, Christopher P. Swain

S1439

A New Field of Endoscopic Treatment, Superficial Pharyngeal Cancer: A Case Series of 115 Superficial Cancers Manabu Muto*, Keiko Minashi, Tomonori Yano, Shigeaki Yoshida, Satoshi Fujii, Atsushi Ochiai

S1440

A Multicenter, Prospective Randomized Trial Comparing Two Types of Self-Expanding Stents in the Palliation of Malignant Dysphagia: SEMS (Ultraflex Stent) Versus SEPS (Polyflex Stent) Axel Eickhoff*, Dirk Hartmann, Ralf Kiesslich, Stefan Turi, Jens Eickhoff, Juergen F. Riemann

P-158

S1441

Stepwise Circumferential and Focal Radiofrequency Energy Ablation of Barrett's Esophagus with Early Neoplasia: First European Multi-Centre Trial Roos E. Pouw*, Carine Sondermeijer, Fiebo J. ten Kate, Paul Fockens, Pierre Eisendrath, Jacques M. Deviere, Katja Wirths, Horst Neuhaus, Jacques J. Bergman

S1442

Colonoscopic Full-Thickness Resection of Colon in a Porcine Model As a Prelude to Endoscopic Surgery of Difficult Colon Polyps - A Novel Technique Gottumukkala S. Raju*, Ijaz Ahmed, Phillip Bordelon

S1443

Palliation in Patients with Malignant Gastric Outlet Obstruction with the Newly Designed Wallflex Duodenal Stent: First Data of a Multicenter, Prospective Trial Axel Eickhoff*, Georg F. Kaehler, Dietmar Meessen, Klaus Gutberlet, Hans-Joachim Schulz, Uwe Will, Carsten Gartung, Diether Ludwig, Karel Caca

S1444

Combination of a New Traction Device “S-O Clip” and Mantishook-Assisted Endoscopic Submucosal Dissection for Superficial Colorectal Neoplasms Naoto Sakamoto*, Taro Osada, Tomoyoshi Shibuya, Kazuko Beppu, Kenshi Matsumoto, Hiroki Mori, Yuji Shimada, Akihiko Kurosawa, Akihito Nagahara, Michiro Otaka, Toshifumi Ohkusa, Tatsuo Ogihara, Sumio Watanabe

S1445

The Use of 2TQ260M Endoscope with Bipolar Needle Knife (B-Knife) and Insulation-Tipped Knife (IT-Knife) Could Conduce to the Swiftness and Precision in ESD Procedure Akihiko Kurosawa*, Akihito Nagahara, Yuji Shimada, Taiji Takahashi, Hiroki Mori, Kenshi Matsumoto, Yoshiaki Kawakubo, Akira Konno, Tomoyoshi Shibuya, Naoto Sakamoto, Taro Osada, Masato Kawabe, Takashi Yoshizawa, Michiro Otaka, Tatsuo Ogihara, Sumio Watanabe

S1446

Transoral Incisionless Fundoplication: Results At 2 Years Giovanni Dapri*, Amin Rajan, Jacques Himpens, Guy Bernard Cadiere

S1447

Thin Endosocope Assisted-Endoscopic Submucosal Dissection (TEA-ESD) of Large Tumors Located in Rectum and Sigmoid Colon Toshio Uraoka*, Jun Kato, Keita Harada, Shin Ishikawa, Keisuke Hori, Hideyuki Suzuki, Motoaki Kuriyama, Yoshiro Kawahara, Hiroyuki Okada, Kazuhide Yamamoto

S1448

Intragastric Balloons for Obesity: An Australian Single Centre Experience Michael N. Merrett*, Sharon J. Marks, Stacey Counsel, Boyd J. Strauss

S1449

Argon Plasma Coagulation with 1% Alum Irrigation Reduces Re-Bleeding Associated with Radiation Proctitis Kaumudi Somnay*, Ellen Gutkin, Ratesh Khillan, P. Patrick Basu, Natalya Belova, Raj Wadgaonkar, Dattatreyudu Nori

S1450

Endoluminal Fundoplication with the Esophyx Device for the Treatment of GERD. A Prospective Study with 6Month Follow-Up Alessandro Repici*, Roberta Barbera, Camilla Gambaro, Uberto Fumagalli, Alberto Malesci, Riccardo Rosati

S1451

Autologous Blood Provides the Best Cushioning Effect for Polypectomy: A Prospective Randomized Controlled Human Trial Samuel A. Giday*, Eun Ji Shin, Sergey V. Kantsevoy

S1452

Invisible Gastric Carcinoma Detected By Random Biopsy (“Biopsy Gastric Cancer”): Long-Term Results After Photodynamic Therapy Thomas Rabenstein*, Andrea May, Liebwin Gossner, Hendrik Manner, Oliver Pech, Michael Vieth, Manfred Stolte, Christian Ell

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL S1453

Effect of Water-Jet Function On Endoscopic Submucosal Dissection for Early Gastric Cancer: A Prospective Randomized Controlled Trial Noriya Uedo*, Koichi Tatsumi, Hiroyasu Iishi, Shunsuke Yamamoto, Sachiko Yamamoto

S1465

Prospective Randomized Comparison of a New ReOpening Endoclip with a Standard Clipping System Andreas Adler*, Ioannis S. Papanikolaou, Wilfried VeltzkeSchlieker, Maria Papas, Bertram Wiedenmann, Thomas Roesch

S1454

Long Term Follow Up Results of Endoscopic Resection for Early Colon Cancer Won Young Cho*, Ji Hoon Kim, Soo Hoon Eun, Jin-Oh Kim, Joo Young Cho, Joon Seong Lee, Chan Sup Shim, Boo Sung Kim

S1466

Usefullness of Endoscopic Submucosal Dissection (ESD) in Treatment of Colorectal Neoplasm Jinwoong Cho*, Young Jae Lee, Gummo Jung, Jiwoong Kim, Yong Keun Cho

S1467

S1455

Endoscopic Mucosal Resection Using a Cap (EMR-C) of Flat, Non-Ampullary Duodenal Adenomas: Safety, Feasibility and Efficacy in 32 Cases Paul Christiaens

The Significance of Tissue Immunohistochemical Staining After ESD of Early Gastric Cancer Hyun Gun Kim*, Seong Hwan Kim, Joo Young Cho, Yu Seoung Seo, Tae Hee Lee, Jin-Oh Kim, Joon Seong Lee, So Young Jin, Chan Sup Shim, Boo Sung Kim, Seok R. Choi

S1456

Push and Pull Enteroscopy Using Single-Balloon Enteroscope System: Technique, Feasibility and Preliminary Results Maria Elena Riccioni*, Enrico C. Nista, Cristiano Spada, Riccardo Urgesi, Paola Fuso, Guido Costamagna

S1468

Successful Endoscopic En Bloc Dissection of Gastric Masses Using Rat-Toothed Forceps Arnab Biswas*, Abraham Mathew

S1469

Technical Feasibility and Clinical Impact of Circumferential Endoscopic Submucosal Dissection (Circumferential ESD) for Superficial Esophageal Cancer Hitomi Minami*, Haruhiro Inoue, Shigeharu Hamatani, Shin-ei Kudo

S1470

Feasibility and Safety of Endoscopic Submucosal Dissection (ESD) for Treatment of Colorectal Tumors and Effectiveness of Measures to Prevent Complications. -Compared to Therapeutic Results from Gastric ESDMasakatsu Fukuzawa*, Satoru Taira, Mikinori Kataoka, Hiroko Hara, Chizuko Manabe, Fumihiko Yanagisawa, Hiroyuki Tachibana, Masaya Nonaka, Yasutaka Hayama, Kenji Yagi, Toshihiro Oshima, Mari Ko, Kohei Kawakami, Takao Itoi, Takashi Kawai, Yoshihiro Sakai, Fuminori Moriyasu

S1457

S1458

S1459

S1460

Final Results of a Prospective Multicentre, Clinical Study On the Efficacy of the New Wallflex Enteral Stent in Malignant Gastric Outlet Obstruction (DUOFLEX) Jeanin van Hooft*, Madeleen Uitdehaag, Marco Bruno, Marcel.G.W. Dijkgraaf, Robin Timmer, Peter D. Siersema, Paul Fockens Retrospective Analysis of Radical Incision and Cutting (RIC) for Benign Refractory Stricture After Curative Treatment for Upper Gastrointestinal Carcinomas Shinya Tsuruta*, Tomonori Yano, Manabu Muto, Yuki Asada, Takahiro Horimatsu, Keiko Minashi, Kazuhiro Kaneko, Atsushi Ohtsu A Novel Device for Endoscopic Submucosal Dissection That Combines Water-Jet Submucosal Hydrodissection and Elevation with Electrocautery Gloria Fernandez-Esparrach*, Erica L. Matthes, Dan Maurice, Markus D. Enderle, Christopher C. Thompson, David L. Carr-Locke “Loop Clip,” a New Closure Device for Large Mucosal Defects After EMR and ESD Naoto Sakamoto*, Kazuko Beppu, Kenshi Matsumoto, Tomoyoshi Shibuya, Taro Osada, Hiroki Mori, Yuji Shimada, Akira Konno, Akihiko Kurosawa, Akihito Nagahara, Michiro Otaka, Toshifumi Ohkusa, Tatsuo Ogihara, Sumio Watanabe

S1461

Preliminary Performance Results of a Flexible, Cap and Catheter-Based Endoscopic Suturing System Christopher J. Gostout

S1462

Polypectomy During Double-Balloon Endoscopy in the Small Bowel: Feasibility and Safety Soeresh V. Jarbandhan*, Stijn J. Van Weyenberg, Willem M. van der Veer, Chris J. Mulder, Maarten A. Jacobs

S1463

Argon Plasma Coagulation for Flexible Endoscopic Zenker Diverticulotomy Thomas Rabenstein*, Andrea May, Hendrik Manner, Liebwin Gossner, Oliver Pech, Christian Ell

S1464

Prospective Comparative Study of Minor Sphincterotomy Combined with Endoscopic Papillary Large Balloon Dilation and Sphincterotomy for Large Bile Duct Stones Young Koog Cheon, Hyun Gun Kim*, Young Deok Cho, Jong Ho Moon, Do Hyun Park, Sang-Heum Park, Joon Seong Lee, Moon Sung Lee, Chan Sup Shim

S1471

Selection of Knife Devices According to the Situation for Use in Endoscopic Submucosal Dissection Atsushi Imagawa*, Yoshiro Kawahara

S1472

Endoscopic Anti-Reflux Therapy Using the Esophyx Endoluminal Fundoplication Device: Results of the First U.K. Study Philippa Youd*, Anton V. Emmanuel, Eric Tripoli, Amanda J. Roy, Krysia Konieczko, Jonathan Harris, Chris H. Fraser

S1473

A New Flexible Endoscopic Suturing Method with Laparoscopic Protection for Safer Full-Thickness Attachment to the Gastro-Intestinal Tract Paul Swain*, John Cullen, James Wright, Cole Chen, Jeff Vasek, Terry Dahl, Pauline McEwan, Mitch Dann, Santiago Horgan

S1474

Resection Area of 15mm As Dividing Line for Choosing Strip Biopsy or Endoscopic Submucosal Dissection for Mucosal Gastric Neoplasm Yasuharu Yamaguchi*, Kenji Nakamura, Masao Toki, Kei Aoki, Shin-ichi Takahashi

S1475

Complications Following Circumferential Radiofrequency Energy Ablation of Barrett's Esophagus Containing Early Neoplasia Roos E. Pouw*, Joep J. Gondrie, Frederike G. Van Vilsteren, Carine Sondermeijer, Wilda Rosmolen, Wouter L. Curvers, Lorenza Alvarez Herrero, Fiebo J. ten Kate, Kausilia K. Krishnadath, Paul Fockens, Bas L. Weusten, Jacques J. Bergman

S1476

Novel Endoscopic Application of a New Flexible Fiber CO2 Laser for Esophageal Mucosal Ablation Sharmila Anandasabapathy*, Dipen Maru, Sherry A. Klumpp, Rajesh Uthamanthil, Agatha Borne, Manoop S. Bhutani

Denotes DDW Poster of Distinction

P-159

S U N D A Y MAY 18

POSTER SESSIONS—CLINICAL

S U N D A Y MAY 18

S1477

Investigation of the Thermal Tissue Effects of the APC Modes Pulsed and Precise On Porcine Esophagus ex vivo and In Vivo Georg F. Kaehler*, Ansgar Hieronymus, Rainer Grobholz, Mara N. Szyrach, Markus D. Enderle

S1478

Investigating the Safety of Weight Reduction Via Endoluminal Vertical Gastroplasty - A U.S. Pilot Study with 6 Months Follow-Up Roberto Fogel*, Hugo Rams, Pedro Greer, Moises Jacobs, Gustavo Plasencia, Eddy Gomez, Juana F. De Fogel

S1479

Use of the Direct Drive Endoscopic System (DDES) for In-Vivo Mucosal Resection in a Porcine Model Richard I. Rothstein*, Lee L. Swanstrom

S1480

Experimental Endoscopic Cardiomyotomy: Preliminary Results Fabio Y. Hondo*, Bruno C. Martins, José H. GiordanoNappi, Fauze Maluf-Filho, Dalton M. Chaves, Eduardo Grecco, Eduardo Guimarães H. de Moura, Ivan Cecconello, Paulo Sakai

S1481

Endoscopic Therapy with a Novel Multiple Clip Applicator (ClipMaster3) in the Upper and Lower GITract Max Bittinger*, Helmut Messmann

S1482

A New Multi-Tasking Platform for Advanced Intralumenal and NOTES Procedures: Learning Curve Assessment, and Accuracy in An Endoscopic Mucosal Resection Model Gloria Fernandez-Esparrach*, Sohail N. Shaikh, Nathaniel J. Soper, Eric S. Hungness, Richard I. Rothstein, Lee L. Swanstrom, Christopher C. Thompson

S1491

Prophylactic APC Ablasion Does Not Decrease Delayed Post-Polypectomy Bleeding Suck-Ho Lee*, Tae Hoon Lee, Jeong Hoon Park, Il Kwun Chung, Hong-Soo Kim, Sang-Heum Park, Sun-Joo Kim

S1492

Immunophenotyping of Blood and Tissue Samples in the Early Healing Stage of Gastric Endoscopic Submucosal Resection in Experimental Pigs Jan Bures*, Zuzana Sinkorova, Marcela Kopacova, Jaroslav Kvetina, Zbynek Svoboda, Stanislav Spelda, Stanislav Rejchrt

S1493

Endoscopic Submucosal Dissection for Early Oropharyngeal and Hypopharyngeal Cancers Toshiro Iizuka*, Daisuke Kikuchi, Shu Hoteya, Naohisa Yahagi

S1494

Endoscopic Submucosal Dissection for En Bloc Resection of Large Colorectal Adenomas: Experience in a Western Population Hubert Piessevaux*, Olivier Dewit, Kassem Azzouzi, Anne Jouret-Mourin, Christine Sempoux, Pierre H. Deprez

S1495

Expanded Indication of Endoscopic Submucosal Dissection (ESD) for Early Gastric Cancer (EGC) -Clinical Outcomes of a Prospective StudyTomoki Michida*, Hiroaki Arakawa, Masahiro Ikeda, Tomoyo Kanno, Tamiko Matsuura, Aya Moriguchi, Kenji Ikezawa, Akiko Ono, Tatsunori Mizuno, Kosaku Maeda, Hiroshi Aketa, Tomofumi Akasaka, Masafumi Naito, Kazuhiro Katayama

S1496

A New Approach to Therapeutic ERCP After Long-Limb Roux-en-Y Gastric Bypass Surgery: A Porcine Study Lincoln E. Ferreira, Thomas C. Smyrk, Todd H. Baron*

S1483

Predictors of Immediate Bleeding During Endoscopic Submucosal Dissection in Gastric Lesions SeongWoo Jeon*, YoungOh Kweon, Won Young Tak, SungKook Kim, Cho ChangMin, Yong Hwan Choi, MinKyu Jung

S1497

Wallflex Biliary Uncovered Stent for Malignant Biliary Obstruction: Initial Experience with Feasibility, Safety, and Effectiveness Elizabeth Verna*, Shashin Shah, Vasudha Dhar, Peter D. Stevens

S1484

A New Method for Barrett's Mucosal Excision Rudolf J. Stadlhuber*, Fumiaki Yano, Wayne E. Penka, Sumeet K. Mittal, Richard I. Rothstein, Charles J. Filipi

S1498

S1485

Endoscopic Submucosal Dissection (ESD) Comes to America: Preliminary Experience with Colorectal ESD At An American Tertiary Care Academic Medical Center Mainor R. Antillon*, Wilson P. Pais, Christopher R. Bartalos, Alberto A. Diaz-Arias, Ghassan M. Hammoud, Daphne Antillon, Priyanka Tiwari, Jamal A. Ibdah, John B. Marshall

Feasibility of Electrocautery Snaring As the Final Step of Endoscopic Submucosal Dissection for Stomach Epithelial Neoplasms Osamu Goto*, Mitsuhiro Fujishiro, Shinya Kodashima, Naomi Kakushima, Satoshi Ono, Naohisa Yahagi, Masao Omata

S1499

Tissue Anchors for Incisionless Surgery - Durability in a Chronic Model Peter M. Denk*, Lee L. Swanstrom

S1500

Treatment of Anastomotic Leakage and Benign Esophageal Perforation By Esophageal or Colorectal Self-Expandable Metal Stents (SEMS) Dimitri Coumaros*, Niki Tsesmeli, Dimitris Tzilves

S1501

Endoscopic Stenting Versus Surgical Gastrojejunostomy for Palliation of Malignat Gastroduodenal Obstruction Rodrigo Castaño*, Oscar A. Alvarez, Jorge Lopera, Eugenio Sanin, Faruk Erebrie, Edilberto Nuñez, Luz E. García

S1502

Self-Expanding Metal Stents in Malignant and Benign Colonic Obstructions Rodrigo Castaño*, Juan D. Puerta, Oscar A. Alvarez, Jorge Lopera, Eugenio Sanin, Faruk Erebrie, Edilberto Nuñez, Luz E. García

S1503

Expandable Nitinol Stent for Treatment of Malignant and Benign Esophagorespiratory Fistulas Rodrigo Castaño*, Oscar A. Alvarez, Jorge Lopera, Eugenio Sanin, Edilberto Nuñez, Luz E. García

S1486

Experience with Endoscopic Resection of Gastrointestinal Subepithelial Tumors Do Kim*, In D. Jeong, Seok Won Jung, Jung Woo Shin, Sung-Jo Bang, Neung H. Park

S1487

Comparative Randomized Study Between TN-PEG Versus O-PEG in Unselected Population Italo Stroppa*, Raffaella Lionetti, Mario Erboso, Enrico Grasso, Fabio Andrei, Francesco Pallone

S1488

Experience with a Removable Self-Expanding Plastic Esophageal Stent (Polyflex® Stent) As a Continuous, Non-Permanent Dilator for Refractory Benign Esophageal Strictures Kulwinder S. Dua*, Peter D. Siersema

S1489

Technique and Instrumentation for Sub-Mucosal Endoscopy with Mucosal Resection (SEMR) Christopher J. Gostout

S1490

Direct Cholangioscopy By Free-Hand Cannulation for Diagnosis and Therapy of Biliary Diseases Brian C. Brauer*, Amrita Sethi, Raj J. Shah, Norio Fukami, Luowei Wang, Chang Beom Ryu, Yang K. Chen

P-160

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL ASGE Poster Session 8:00 AM - 5:00 PM

S1515

A Prospective Application of a Risk Score for Post-ERCP Pancreatitis Susana Galindo Marines*, Ricardo Flores Rendon, Rafael Castañeda-Sepulveda, Aldo A. Garza, Jorge Gonzalez Maldonado, Hector J. Maldonado, Jose A Gonzalez

S1516

Clinical Relevance of Microbial Colonization in the Bile Fluid of Patients with Biliary Complications After Liver Transplantation Alexander Dechene*, Evangelos Efthimiadis, Vito Cicinnati, Karl-Dieter Müller, Guido Gerken, Thomas Zoepf, Philip A. Hilgard

S1517

Complications After Endoscopic Retrograde Cholangiopancreatography: Multivariable Analyses for Pancreatitis, Cholangitis and Hemorrhage Suzanne M. Jeurnink*, E. W. Steyerberg, Peter D. Siersema, Jelle Haringsma, Jan-Werner Poley, Jan Dees, E. J. Kuipers

S1518

Palliation of Tumoral Biliary Obstruction. Short Time Effect On Cholestasis By Self-Expanding Metal Stents (SEMS) Vs Plastic Stents (PS) Prospective, Randomised Study Josep M. Bordas*, Ana Adet, Josep Llach, F. Mondelo, Maria Pellisé, Angels Gines, Gloria Fernandez-Esparrach, Alfredo Mata Bilbao, Michel Zabalza, Oriol Sendino, Josep M. Pique, Antoni Castells

S1519

Prospective Analysis of Early and Delayed Complications of Endoscopic Sphincterotomy At a Single Centre Markus Sagmeister*, Janek Binek, Jan Borovicka, Daniel Boller, Christina A. Knellwolf, Christa Meyenberger

Sails Pavilion San Diego Convention Center

ERCP BILIARY S1504

S1505

Yield of Repeat ERCP for Persistently Elevated LfTs After a Previously Normal Cholangiogram in Liver Transplant Patients with Choledochocholedochostomy Anastomosis Mouen Khashab*, Evan L. Fogel, Lee McHenry, James L. Watkins, Pradermchai Kongkam, Furqaan Ahmed, Suzette E. Schmidt, Laura Lazzell-Pannell, Stuart Sherman, Glen A. Lehman Dye-Free Cannulation of the Biliary Tree: Outcomes in a Single Operator Experience of 800 Cases Dharmendra Verma, Kristen Hilden, Romil Chadha, Kristen Thomas, Douglas G. Adler*

S1506

Is Percutaneous Drainage of Intra-Abdominal Bile Necessary for Post-Cholecystectomy Bile Leaks in the Era of Successful ERCP Management? Daniel P. Hammond, Ramu Raju, Burr J. Loew, Michele B. Delenick, Harsha Vittal, Douglas A. Howell*

S1507

Papillectomy for Ampullary Neoplasm: Results of a Single Referral Center from 1997 to 2007 Shayan Irani*, Andrew D. Arai, Kamran Ayub, John J. Brandabur, Russell Dorer, Margaret Farrell-Ross, Michael Gluck, Geoffrey Jiranek, David Patterson, Drew Schembre, Richard A. Kozarek

S1508

Effect of Vardenafil, a Phosphodiesterase Type 5 Inhibitor, On Sphincter of Oddi Motility in Patients with Suspected Sphincter of Oddi Dysfunction Young Koog Cheon*, Young Deok Cho, Jong Ho Moon, Hee Hyuk Im, Yun Jung, Joon Seong Lee, Moon Sung Lee, Chan Sup Shim

S1520

EUS Rendezvous for Transpapillary Biliary Access After Unsuccessful ERCP; 9 Years' Experience At a Single Center Yeonsuk Kim*, J. Shawn Mallery, Rebecca Lai, Timothy P. Kinney, Kapil Gupta, Anhtung Chau, Oliver W. Cass, Kamran Safdar, Martin L. Freeman

S1509

Nafamostat Mesilate for Prevention of Post-ERCP Pancreatitis Kyo-Sang Yoo*, Won Sub Choi, Yong Woo Chung, Kyoung Oh Kim, Cheol Hee Park, Taeho Hahn, Sang Hoon Park, Jong Hyeok Kim, Jin Lee, Choong Kee Park

S1521

Deep Cannulation of Intra-Diverticular Papilla At ERCP: Advanced Techniques and Results Ramu Raju*, Douglas A. Howell, Michele B. Delenick, Burr J. Loew, Daniel P. Hammond, Arathi Rao, Michael K. Sanders, Harsha Vittal

S1510

Prophylactic Stent Placement for Prevention of PostERCP Pancreatitis: A Meta-Analysis Abhishek Choudhary*, Matthew L. Bechtold, Mohamed O. Othman, Srinivas R. Puli, Wilson P. Pais, Mainor R. Antillon, Praveen K. Roy

S1522

ERCP Using the Double Balloon Enteroscope in Patients with Roux En Y Anastomosis Klaus Mönkemüller*, Michael Bellutti, Helmut Neumann, Lucia C. Fry, Peter Malfertheiner

S1511

ERCP-Induced Pancreatitis in Primary Sclerosing Cholangitis: Risk Factors and Proposed Scoring System for Guiding Prophylactic Pancreatic Stent Therapy Ferga C. Gleeson*, Todd H. Baron, Felicity Enders, Gregory J. Gores, Andrea A. Gossard, Christopher J. Gostout, Keith D. Lindor, Bret T. Petersen, Mark D. Topazian, Michael J. Levy

S1523

Prospective Study of Intraductal Ultrasonography Before Biliary Drainage (IDUS-BD), Transpapillary Biopsy (TPB) and Peroral Cholangioscopy (POCS) in Assessment of the Longitudinal Extent of Bile Duct Cancer Yutaka Noda*, Naotaka Fujita, Go Kobayashi, Kei Ito, Jun Horaguchi, Osamu Takasawa, Takashi Obana, Takashi Tsuchiya, Takashi Sawai

S1512

Safety and Effectiveness of Early Pre-Cut Sphincterotomy Without Pancreatic Stenting for Failed Biliary Cannulation Marcelo S. Cury*, Mandeep S. Sawhney, James C. Ellsmere, Rabi Kundu, Siwar Albashir, Jonathan Underhill, Ram Chuttani

S1524

Meta-Analysis of Magnetic Resonance Cholangiopancreatography (MRCP) Demonstrates High Predictive Value of MRCP for Primary Sclerosing Cholangitis (PSC) Maneesh Dave*, B. Joseph Elmunzer, Ben A. Dwamena, Peter D. Higgins

S1513

Performance Characteristics of a New Uncovered Metal Stent (Wallflex) in Malignant Biliary Obstruction. Preliminary Results in a Case Series Alberto Herreros de Tejada*, Jennifer S. Chennat, Charles E. Dye, Isabel Millan, Barbara M. Cislo, Lynne Stearns, Irving Waxman

S1525

Internal Biliary Drainage Is Superior to External Drainage in Reversal of the Elevated Serum Endotoxin, Interlukin-2 and Interlukin-6 in Rats with Obstructive Jaundice Yichun Gong*, Wen Li

S1514

ERCP in Nonagenarians: An Audit of Practice Yogananda Reddy*, Jayapal Ramesh, Lynne Wilbraham, Derrick F. Martin

S1526

Hospitalization and in-Hospital Mortality of Cholangitis in the Advent of Therapeutic Biliary ERCP M Mazen Jamal, Zarema Singson*, David Yamini, Kenneth J. Vega

Denotes DDW Poster of Distinction

P-161

S U N D A Y MAY 18

POSTER SESSIONS—CLINICAL S1527

Safety of Non-Anesthetist Sedation with Propofol During Endoscopic Retrograde Cholangiopancreatography (ERCP): 10 Years of Experience Marcello Orlandi*, Manuela Noesberger, Daniel Kuelling, Christophe Petrig, Werner Inauen

S1528

Role of Double Guide Wire Cannulation During ERCP Shahzad Iqbal*, Prashant Sharma, Shashin Shah, Vasudha Dhar, Stavros N. Stavropoulos, Peter D. Stevens

S1529

Dose Biliary Stent Placement Improve the Quality of Life of Patients with Unresectable Malignant Obstruction? Yukiko Ito*, Hiroyuki Isayama, Takeshi Tsujino, Takao Kawabe, Masao Omata

S1530

Fixed-to-Last: Long-Term Outcomes of Orthotopic Liver Transplant Biliary Complications Managed Endoscopically Anthony Schore*, Denise M. Harnois, Justin H. Nguyen, Andrew Stockland, Michael B. Wallace, David S. Loeb, Stephen Lange

S1531

S U N D A Y

S1541

Participation in An Initial Clinical Registry Influences Subsequent Utilization of the SPYGLASS™ Cholangioscopy System Andrew S. Ross*, Richard A. Kozarek

S1542

Feasibility of Percutaneous Transhepato-Cholecystic Biliary Interventions After Failed Endoscopic Attempt kensuke kubota*, Masahiko Inamori, Atsushi Nakajima

S1543

Laparo-Endoscopic Rendezvous Technique in Patients with Gallbladder and Bile Duct Stones. Chilean Experience Hugo Richter*, Eduardo Valdivieso, Javier Ormazabal, Jaquelina Gobelet, Alberto Rodriguez Navarro, Carlos Aguayo, Claudio Navarrete

S1544

Hinged Metallo-Plastic Anastomosis Device; A Novel Intraluminal Method for Choledochoduodenostomy Priya A. Jamidar*, Margherita Cadeddu, Charles A. Mosse, Michael Boyd, Christopher P. Swain

S1545

Fully Covered Self-Expandable Metallic Stents in the Management of Complex Biliary Leaks: Preliminary Data Andrew Y. Wang, Steven L. Condron, Kristi Ellen, Berg L. Carl, Timothy M. Schmitt, Michel Kahaleh*

S1546

Treatment Selection for Possible Sphincter of Oddi Dysfunction Based On Manometry Is Effective in Treatment of Gastrointestinal Symptoms and Quality of Life Nalini M. Guda*, Ramanujan Samavedy, Susan Partington, Marc F. Catalano, Joseph E. Geenen

S1547

Safety and Efficacy of Endoscopic Ampullectomy in Tumors with and Without Intraductal Growth and Predictive Factors of Success: A Prospective Trial Hany Shehab, Louis Buscail, Barbara Bournet, PierreAntoine Gourraud, Jean Escourrou*

S1548

Short (Short Rendezvous Technique): A New ERCP Rendezvous Technique Juan C. Ayala*, Ricardo Labbe, Juan E. Vera

Clinicopathological Differentiation Between Autoimmune Hepatitis /Primary Sclerosing Cholangitis (PSC) Overlap Syndrome (AIH/PSC), Psc and Sclerosing Cholangitis with Autoimmune Pancreatitis Takayoshi Nishino*, Fumitake Toki, Etsuko Hashimoto, Keiko Shiratori

S1549

Efficacy of the Endoscopic Therapy of Biliary Fistulas Secondary to Complex Liver Resections Anne Bourrier*, Ariane Chryssostalis, Marianne Gaudric, Stanislas Chaussade, Frédéric Prat

An Interim Analysis of Outcomes Following Use of a Needle Catheter for Biliary Access in Patients with Severe Coagulopathy and Choledocholithiasis Everson Artifon*, Atul Kumar, Renato Baracat, Paulo Sakai

S1550

Late Complications of Endoscopic Sphincterotomy in Comparison to Endoscopic Papillary Balloon Dilation in Patients with Bile Duct Stones: A Randomized Controlled Multicenter Trial Ichiro Yasuda*, Naotaka Fujita, Hiroyuki Maguchi, Yutaka Komatsu, Osamu Hasebe, Yoshinori Igarashi, Akihiko Murakami, Hidekazu Mukai, Tsuneshi Fujii, Kenji Yamao, Kensei Maeshiro, Takeshi Tsujino, Tomoko Tada

S1551

Long-Term Outcomes (Mean Follow-Up Period > 10 Years) of Endoscopic Papillary Balloon Dilation for Bile Duct Stones Takeshi Tsujino*, Hiroyuki Isayama, Yukiko Ito, Hiroshi Yagioka, Yoko Yashima, Hirofumi Kogure, Takashi Sasaki, Osamu Togawa, Toshihiko Arizumi, Saburo Matsubara, Yousuke Nakai, Naoki Sasahira, Kenji Hirano, Minoru Tada, Takao Kawabe, Masao Omata

S1552

Endoscopic Treatment of Retained CBD Stones By Using a Double-Lumen Basket for Freddy Laser Lithotripsy Jong Ho Moon*, Hyun Jong Choi, Su Jin Hong, Young Koog Cheon, Young Deok Cho, Joon Seong Lee, Moon Sung Lee, Chan Sup Shim

Endoscopic Bilateral Metal Stent Placement with a YConfigured Stent for Advanced Hilar Cholangiocarcinoma Jae Sup Eum*, Dae Hwan Kang, Chan Ho Park, Kyung Yeob Kim, Tae In Ha, Cheol Woong Choi, Hyoung Yoel Park, Il Doo Kim, Gwang Ha Kim, Jeong Heo, Geun-Am Song, Mong Cho

S1532

Endoscopic Management of Biliary Tract Complications in the Liver Transplant Patient Victor Torres, Glenn W. Gross, Sandeep Patel*

S1533

Jackson Pratt Drain Fluid to Serum Bilirubin Concentration Ratio for the Diagnosis of Bile Leaks Peter E. Darwin, Eric M. Goldberg, Lance T. Uradomo*

S1534

A Comparative Study of Outcomes Between Endoscopic Papillary Large Balloon Dilatation (EPLBD) and Endoscopic Mechanical Lithotripsy (EML) in Patients with Difficult CBD Stones Dongyoub Cha, Byungmoo Yoo*

MAY 18 S1535

S1536

S1537

Single-Operator Cholangioscopy Enhances Diagnostic and Therapeutic Applications of Endoscopic Retrograde Cholangiopancreatography Udayakumar Navaneethan, Joseph B. Palascak, Mayar Al Mohajer, Shailendra S. Chauhan, Andres Gelrud*

S1538

Gallbladder Carinoma Associated with Pancreatobiliary Reflux: A Hint for Early Diagnosis of Gallbladder Carcinoma Jin Kan Sai*, Masafumi Suyama, Yoshihiro Kubokawa, Yuji Matsumura, Kei Kato, Masayasu Chikamori, Koichi Inami, Kei Anno, Jitsuko Maruki, Sumio Watanabe

S1539

SPYGLASS: Comparison of a New Choledochoscope to Other Established Choledochoscope in Biliary Tract Disease Isaac Raijman*, Douglas S. Fishman

S1540

Traumatic Bile Leaks: Single Center Experience with Endoscopic Management Newton P. Muthunayagam*, Andres Gelrud, Shailendra S. Chauhan

P-162

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL S1553

Endoscopic Management of Patients with Suspected Choledocholithiasis (CBDs) and a Normal Cholangiogram Furqaan Ahmed*, Pradermchai Kongkam, Lee McHenry, Evan L. Fogel, James L. Watkins, Stuart Sherman, Glen A. Lehman

S1554

Risk Factors for Recurrence of Common Bile Duct Stone in Patients with the Gallbladder in situ with Stones After Endoscopic Papillary Balloon Dilation Toshihiko Arizumi*, Takeshi Tsujino, Yoko Yashima, Hiroshi Yagioka, Hirofumi Kogure, Takashi Sasaki, Osamu Togawa, Saburo Matsubara, Yousuke Nakai, Kenji Hirano, Naoki Sasahira, Hiroyuki Isayama, Minoru Tada, Takao Kawabe, Masao Omata

S1555

Endoscopic Clearance of Common Bile Duct Stones: What Happens After? Value of Prophylactic Cholecystectomy Christian P. Selinger*, Yeng S. Ang

S1556

Endoscopic Removal of Bile Duct Stones Using a Rotatable Papillotome and Large Balloon Dilator in Patients with a Billroth II Gastrectomy Jae Sup Eum*, Dae Hwan Kang, Chan Ho Park, Kyung Yeob Kim, Tae In Ha, Cheol Woong Choi, Hyoung Yoel Park, Il Doo Kim, Pyo Jun Kim, Gwang Ha Kim, Jeong Heo, Geun-Am Song, Mong Cho

S1557

Transection of Self-Expanding Metallic Stents By Using Argon Plasma Coagulation: A Basic Study Keiko Kaneko*, Chiaki Kawamoto, Atsushi Yamauchi, Koji Yakabi, Norio Hirota

S1558

S1559

S1560

Biliary Stone or Cast Development in Patients with Postoperative Stricture After Orthotopic Liver Transplantation Ki Young Yang*, Sang Hyub Lee, Jeong Kyun Seo, Sang Myung Woo, Joo Kyung Park, Jin Hyeok Hwang, Jin Wook Kim, Sook Hyang Jeong, Kyung Suk Suh, Ji Kon Ryu, YongTae Kim, Yong Bum Yoon Predictive Value of CT Scanning for Common Bile Duct Stones David J. Desilets*, Abdullah Shaikh The Effect of Biliary Stenting with Combined UDCA and Rowachol Administration On Retained CBD Stones -Multicenter StudyJee Heon Kang*, Jong Ho Moon, Moon Sung Lee, Jimin Han, Ho Gak Kim, Seok Jeong, Don Haeng Lee

S1561

Development and Internal Validation of a Novel Choledocholithiasis Risk Estimation Score Abbasi J. Akhtar

S1562

A Randomized Controlled Trial Comparing the Covered (CSEMS) Versus Uncovered Self-Expandable Metal Stents (USEMS) for the Palliation of Malignant Distal Biliary Obstruction (MDBO): Interim Analysis Ferran Gonzalez-Huix, Carlos Huertas*, Montserrat Figa, Francisco Igea, Diego Juzgado, Jorge C. Espinos, Carlos Dolz Abadia, Rosa E. Madrigal, Manuel Perez-Miranda

S1563

Per Endoscopic Drainage of Hiliary Malignant Stenosis: Predictive Success Factors Ariane Vienne*, Ariane Chryssostalis, Catherine Buffet, Stanislas Chaussade, Frédéric Prat

S1564

Efficacy and Safety of a Fully Covered Self Expandable Metal Stents (CSEMS) for Distal Biliary Neoplasia: Preliminary Data of a Retrospective Multicenter Study Michel Kahaleh*, Lee McHenry, Patrick G. Northup, Stuart Sherman, Glen A. Lehman, John T. Cunningham, Paul Yeaton

S1565

Prevention of Cholecystitis in Patients with Distal Neoplasic Biliary Obstruction Treated with Covered Self-Expanding Metal Stents (CSEMS): A Feasibility Study Sonia Gosain, Andrew S. Brock, Anshu Mahajan, Melissa S. Phillips, Henry C. Ho, Kristi Ellen, Vanessa M. Shami, Michel Kahaleh*

S1566

Repeat Metal Stenting May Be Optimal Initial Treatment for Biliary Metal Stent Occlusion in Malignancy Jason N. Rogart*, Uzma D. Siddiqui, Priya A. Jamidar, Harry R. Aslanian

S1567

Temporary Placement of Fully Covered Self-Expandable Metal Stents (CSEMS) in Benign Biliary Strictures: Preliminary Data Anshu Mahajan, Henry C. Ho, Andrew S. Brock, Vanessa M. Shami, Kristi Ellen, Timothy M. Schmitt, Michel Kahaleh*

S1568

Endoscopic RE-Intervention for the Management of Dysfunction of Covered Metallic Stents in Patients with Malignant Distal Biliary Obstructions Osamu Togawa*, Hiroyuki Isayama, Takeshi Tsujino, Yousuke Nakai, Yoko Yashima, Hiroshi Yagioka, Hirofumi Kogure, Takashi Sasaki, Toshihiko Arizumi, Saburo Matsubara, Yukiko Ito, Naoki Sasahira, Kenji Hirano, Nobuo Toda, Minoru Tada, Haruhiko Yoshida, Takao Kawabe, Masao Omata

S1569

A Comparison of Extension Cytology and Fluorescence in situ Hybridization (Fish) for the Detection of Malignant Bile Duct Strictures Omar Rojas-Pedraza*, Angelica I. Hernández-Guerrero, Juan Octavio Alonso-Larraga, Sergio R. Sobrino-Cossio, Margarita Ibarra Del Rio, Hortencia-Yanet Valdéz-Mendieta, Judith Cruz-Velázquez

S1570

Covered Self Expandable Metal Stents in Border-Line Resectable Pancreatic Carcinoma: Prospective Study Concerning Effectiveness and Safety Javier Jiménez-Pérez*, Jesus Urman, Federico Bolado, Rebeca Irisarri, Miren Vicuña, Fernando Borda

S1571

Efficacy of Endoscopic Stenting On Biliary Strictures After Orthotopic Liver Transplantation: A Prospective Study Paola Cognein*, Luigi Caserta, Maria Caterina Parodi

S1572

Temporary Placement of Covered Self Expandable Metallic Stents (CSEMS) in Anastomotic Biliary Strictures After Liver Transplantation Ariane Chryssostalis*, Gaudric Marianne, Olivier Scatton, Chaussade Stanislas, Frédéric Prat

S1573

A Multi-Center, Single ARM, Prospective Study of a New Partially Covered Nitinol Self-Expanding Stent for the Palliative Treatment of Malignant Bile Duct Obstruction Guido Costamagna*, D. N. Reddy, Jacques M. Deviere, Marco Bruno, Thierry Ponchon, Horst Neuhaus, Andrea Tringali, Massimiliano Mutignani, G. V. Rao, Sandeep Lakhtakia, Paul Fockens, Erik A. Rauws, Vincent Lepilliez, Brigitte Schumacher, Alexander Seelhoff

S1574

Comparison of Standard and Jumbo Endobiliary Biopsy for Histological Diagnosis of Hilar Biliary Strictures: Interim Report of a Prospective Randomized Trial Massimiliano Mutignani*, Domenico Galasso, Pietro Familiari, Andrea Tringali, Federico Iacopini, Cristiano Spada, Riccardo Ricci, Guido Costamagna

S1575

Immunohistochemical Staining Improves the Diagnostic Yield of Bile Duct Biopsies Alexander W. Jahng*, Sonya Reicher, David S. Chung, Binh V. Pham, Jose Nieto, Liya K. Abramyan, Samuel W. French, Viktor E. Eysselein

Denotes DDW Poster of Distinction

P-163

S U N D A Y MAY 18

POSTER SESSIONS—CLINICAL S1576

Clinical Outcomes and Performance of Nitinol and Stainless Steel Uncovered Metal Stents for Malignant Biliary Strictures. Is There a Difference? Brian R. Weston*, William A. Ross, Marta L. Davila, Jeffrey H. Lee

S1577

Removable Covered Expandable Biliary Stent with a Proximal Lasso: Proof of Principle Testing in An Animal Model Rogier P. Voermans*, Chan Sup Shim, Dirk J. Gouma, Erik A. Rauws, Paul Fockens, Marco Bruno

S1578

Frequent and Various Biliary Complications Did Not Compromise the Outcome of Orthotopic Liver Transplantation (OLT): Ten Years Experience with 500 Consecutive Patients J. Spicak*, Milos Adamec, Martin Oliverius, Libor Janousek, Jan Peregrin, Helena Filipova, Petr Stirand, Jan Sperl, Pavel Trunecka

S1579

Endoscopic Treatment of Malignant Hilar Strictures: Plea for Unilateral Drainage with a Single Expandable Metallic Stent Emmanuel Ben-Soussan*, Jean-François Lefebvre, Cyrille Pauphilet, Didier Bonnel, Claude Liguory

S1580

Multiple Sampling Method Increases the Diagnostic Yield in Non Pancreatic Malignant Biliary Obstruction (MBO) John T. Cunningham

S1581

Aggressive Endoscopic Balloon Dilatation and Multiple Stents for Can Lead to Resolution of Post Orthotopic Liver Transplant Biliary Strictures Bing Hu*, Fenghai Yu, Yamin Pan, Like Bie, Tiantian Wang, Biao Gong

S U N D A Y MAY 18

P-164

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC BASIC AASLD Poster Session 8:00 AM - 5:00 PM

S1582



Start Domain Protein Stard4 Is Able to Bind Free Cholesterol and Increases Cholesterol Ester Formation and Microsomal Acat Activity Daniel Rodriguez-Agudo*, Shunlin Ren, Eric Wong, Dalila Marques, Kaye Redford, William M. Pandak

S1583



Bile Acids Regulate Hepatic Stellate Cell Migration Tadashi Ikegami*, Akira Honda, Teruo Miyazaki, Bernard E. Bouscarel, Yasushi Matsuzaki

S1584

Curcumin Suppresses LDL Receptor Gene Expression, Leading to the Inhibition of Cholesterol/LDL-Induced Hepatic Stellate Cell Activation Qiaohua Kang*, Anping Chen



Myofibroblast-Derived Soluble Factors Upregulate Chemokine Gene Expression in Neighboring Cholangiocytes Alessia Omenetti*, Alessandro Porrello, Wing-Kin Syn, Steve S. Choi, Youngmi Jung, Liu Yang, Kevin D. Brown, Rafal P. Witek, Hendrika Vandongen, Anna Mae Diehl

S1586

Activation of ERK1/2 By Nicotine Stimulates Cholangiocarcinoma Proliferation Benjamin F. Perry*, Candace Wise, Michael McNeal, Shannon Glaser

S1587

Compensatory Role of Inducible Annexin A2 for Impaired Biliary Epithelial Anion Exchange Activity of Inflammatory Cholangiopathy Osamu Kido*, Koji Fukushima, Yoshiyuki Ueno, Jun Inoue, Douglas M. Jefferson, Tooru Shimosegawa

S1588

Bone Marrow-Derived Cells Contribute to Extrahepatic Bile Duct Regeneration.- a Study Using a Model for Artificial Bile Duct Implantation Mitsuo Miyazawa*, Masayasu Aikawa, Katsuya Okada, Yasuko Toshimitsu, Yoshihide Otani, Isamu Koyama, Yoshito Ikada

S1589

S1590

 S1591

S1592

Bile Acids Suppress the Hypothalamic-Pituitary-Adrenal Axis: Implications for Cholestatic Liver Diseases Tracy Davis*, Monique Stutes, Sharon DeMorrow

S1594

Liver Damage and Early Morpho-Functional and Oxidative Changes of Colonic Mucosa in the Bile DuctLigated Rat Model Piero Portincasa*, Ignazio Grattagliano, David Q. Wang, Helen H. Wang, Michele Vacca, Antonio Moschetta, Giuseppe Calamita, Giuseppe Palasciano

Sails Pavilion San Diego Convention Center

BILIARY PHYSIOLOGY

S1585

S1593

Castration Reduces Cholangiocyte Hyperplasia and Secretin-Stimulated Ductal Secretion of Bile Duct Ligated (BDL) Rats By Downregulation of the cAMPDependent ERK1/2 Pathway Julie Venter*, Shannon Glaser, Candace Wise, Heather Francis, Bradley T. Vaculin, Shelley Kopriva, Jennifer Savage, Gianfranco Alpini Bile Acid Feeding Prevents Hepatic Artery LigationInduced Bile Duct Injury in Bile Duct Ligated Rats (BDL) By PI3K/AKT-Dependent Activation of Cholangiocyte VEGF-a Expression Shannon Glaser*, Eugenio Gaudio, Heather Francis, Yoshiyuki Ueno, Paolo Onori, Antonio Franchitto, Julie Venter, Domenico Alvaro, Bradley T. Vaculin, Shelley Kopriva, Jennifer Savage, Gianfranco Alpini Chronic Administration of Nicotine Induces Biliary Proliferation in Both Normal and Rats with Extrahepatic Cholestasis Induced By Bile Duct Ligation (BDL) Candace Wise*, Julie Venter, Gianfranco Alpini, Bradley T. Vaculin, Shannon Glaser Alteration of Anion Exchanger 2 Expression and Function in Cholestatic Rat Cholangiocytes Jae-Seung Park, Hong-Soo Kim, Jae Dong Lee, Yoo-Seung Ko, Won Cho*

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

H. PYLORI: GASTRIC EPITHELIAL RESPONSES AND CARCINOGENESIS Participants will be able to: • Evaluate recent research on gastric epithelial responses related to carcinogenesis induced by Helicobacter pylori. S1595

Involvement of EGFR in Helicobacter pylori-Induced Focal Adhesion Kinase Activation and Cytoskeletal ReOrganization in AGS Cells Fazal H. Tabassam*, David Y. Graham, Yoshio Yamaoka

S1596



Helicobacter pylori Induced Activation of PI3K/Akt Signaling Pathway Requires EGFR Signaling Fazal H. Tabassam*, David Y. Graham, Yoshio Yamaoka

S1597

Helicobacter pylori Induces ADAM17 Activation By Promoting ADAM17/Integrinβ1 Dissociation in Gastric Epithelial Cells Monika Gooz, Arindam Saha*, Adam J. Smolka

S1598



Helicobacter pylori Inhibits Proton Pump Expression in Human Gastric Mucosa Arindam Saha*, Charles E. Hammond, Adam J. Smolka

S1599

High Levels of Aberrant DNA Methylation in Helicobacter pylori-Related Pangastritis Eiichiro Yamamoto*, Minoru Toyota, Hiromu Suzuki, Kohzoh Imai, Yasuhisa Shinomura

S1600

IL-10 Knockout and Not Deficiency Suppresses Gastric Low-Grade MALT Lymphoma Formation By Helicobacter Heilmannii Infection Masahiko Nakamura*, Hidenori Matsui, Hiroshi Serizawa, Shinichi Takahashi, Nobuhiko Kamada, Toshifumi Hibi, Hidekazu Suzuki, Kanji Tsuchimoto

S1601

Matrix-Metalloproteases Are Involved in the H. pyloriInduced Downregulation of the Serine Protease Inhibitor SLPI in Gastric Tumor Cells Thomas Wex*, Daniel Schindele, Peter Malfertheiner

S1602

Intracellular Okadaella Gastrococcus Found in Helicobacter pylori Positive Gastric Mucosa Takayuki Okada*, Kazutoshi Hori, Graham Adkins, Rodney McDougall, Jenny Robson, Hiroto Miwa

S1603

Apurinic/Apyrimidinic Endonuclease (APE)-1/Redox Factor (Ref)-1 Enhances Hypoxia Inducible Factor (HIF)-1α Activation in H. pylori-Infected Gastric Epithelium But Inhibits HIF-1α-Mediated Apoptotic Events Asima Bhattacharyya*, Ranajoy Chattopadhyay, Sankar Mitra, Sheila E. Crowe



Denotes DDW Poster of Distinction

P-165

S U N D A Y MAY 18

POSTER SESSIONS—BASIC S1604

S1605

S1606

S1607

S1608

S1609

S U N D A Y

Helicobacter felis Infection Modulates Gastric Sonic Hedgehog Expression and Signaling Meghna Waghray*, Juanita L. Merchant A Long-Term PPI Administration Induces Atrophic Corpus Gastritis and Promotes Development of Atypical Glands in Mongolian Gerbils Infected with Helicobacter pylori Tadashi Hagiwara*, Ken-ichi Mukaisho, Hiroyuki Sugihara, Takanori Hattori Ten-Year Follow-Up Study On the Incidence of Gastric Cancer and the Pathological Changes of Gastric Mucosa After H. pylori Eradication in China Liya Zhou Earlier H. pylori Eradication Restores Sonic Hedgehog (Shh) Expression in the Gastric Mucosa Toshihiro Nishizawa*, Hidekazu Suzuki, Etsuko Sugai, Izumi Nakagawa, Tatsuhiro Masaoka, Eisuke Iwasaki, Yoshimasa Saito, Toshifumi Hibi Coexisting Gastric Cancer and Duodenal Ulcer: Distrubution of Atrophic Gastritis and Intestinal Metaplasia Soo-Jeong Cho*, Il Ju Choi, Chan Gyoo Kim, Jong Yeul Lee, Myeong-Cherl Kook Clinical Evaluation of Helicobacter pylori TyrosinePhosphorylated cagA in Diffuse-Type Gastric Cancer Patients: A Case-Control Study Yoshihiro Wada*, Masanori Ito, Shunsuke Takata, Shosuke Kitamura, Akemi Takamura, Masana Tatsugami, Shinobu Imagawa, Yoshiaki Matsumoto, Shinji Tanaka, Masaharu Yoshihara, Kazuaki Chayama

S1610

Effects of Helicobacter pylori-Secreting Protein Tip α On the Human Gastric Epithelial Cell GES-1 Shi R. Hua*, Ping Cheng, Hongjie Zhang

S1611

Effect of H. pylori Infection On Expression of TFF2 in Rhesus Monkeys Matthew Goldman*, Cristina Semino-Mora, Arifur Rahman, Hui Liu, Wilfred De La Cruz, Carolyn A. Sullivan, Andre Dubois

MAY 18 S1612

S1613

S1614

Helicobacter pylori Infection Diminish the IFN-γ Secretion By T Lymphocytes in Response to Stimulation with Different Agents in Children Czkwianianc Elzbieta*, Wieslawa Rudnicka, Magdalena Chmiela, Ewa Malecka-Panas Role of Free Radical and Mucus in Rat Experimental Model of Gastritis with Ammonia; Combined Effect of Anti-Ulcer Agent Geranylgeranylacetone Eiji Umegaki*, Takao Noguchi, Keishi Kojima, Nanako Shiraishi, Toshihisa Takeuchi, Satoshi Tokioka, Yukiko Yoda, Nozomi Takeuchi, Chikako Eiraku, Kazuhide Higuchi Effects of Helicobacter pylori Infection On Mucin Phenotype of Early Differentiated Gastric Carcinoma; Study with Gastric Mucosal Specimens Obtained By Endoscopic Mucosal Resection Eiji Umegaki*, Chikako Eiraku, Satoshi Tokioka, Nozomi Takeuchi, Toshihisa Takeuchi, Nanako Shiraishi, Yukiko Yoda, Kazuhide Higuchi

S1615

Helicobacter pylori cagA Increases C-Jun Expression By the Orphan Nuclear Receptor Shp Induction in Gastritis Won Il Park, Hyung Wook Kim*, Jin Kwang An, Kwang Jin Kim, Hye Young Kim, Jae Hun Cheong, Geun-Am Song, Ung Suk Yang

S1616

Characteristics of Coexistent Duodenal Ulcer and Gastric Cancer: Role of Helicobacter pylori Kyung Sun Ok, Jeong Seop Moon*, Won Cheol Jang, Tae Yeob Jeong, Jin Gook Huh, Soo Hyung Rye, Jung Hwan Lee, You Sun Kim, Hang Jong Yu, Byoung Jo Suh

P-166

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

MUCOSAL INJURY, REPAIR, AND HEALING Participants will be able to: • Understand basic aspects of mucosal injury, repair, and healing. S1617



M-Numb and Notch Signals Are the Key Factors for Gastric Mucosal Regeneration After Acute Damage Tetsufumi Takahashi*, Hidekazu Suzuki, Yoshimasa Saito, Tatsuhiro Masaoka, Hiroshi Nagata, Yumi Matsuzaki, Hideyuki Okano, Toshifumi Hibi

S1618

Phospholipase C-γ1 Regulates CA2+ Influx By Interacting with TRPC1 Channels Promoting Early Mucosal Restitution After Wounding Rao N. Jaladanki*, Tongtong Zou, Lan Liu, Lan Xiao, Douglas J. Turner, Jian-Ying Wang

S1619



MMP9-Mediated Upregulation of Endostatin and Downregulation of VEGF in Aging Gastric Mucosa: Novel Mechanism for Impaired Angiogenesis Xiaoming Deng*, Amrita Ahluwalia, Ximing Xiong, Sandor Szabo, Zsuzsanna Sandor, Andrzej Tarnawski

S1620

CDx2 Expression Is Regulated By BMP/SMAD4 Pathway in Human Gastric Carcinoma Cell Lines Rita Barros*, Bruno Pereira, Isabelle Duluc, Nuno M. Mendes, Paula Paulo, Filipe Santos-Silva, Isabelle VAN SEUNINGEN, Leonor David, Jean-Noel Freund, Raquel Almeida

S1621

DOCK5, a Novel Protein Related to the Guanine Nucleotide Exchange Factor DOCK180, May Regulate CACO-2 Intestinal Epithelial Cell Spreading and Migration Via Interaction with CRK Matthew A. Sanders*, Marc D. Basson

S1622

Calcium Transients Activate the Cyclin-Dependent P34cdc2 Kinase Via Calmodulin Resulting in Stabilization/Accumulation of the Anti-Apoptosis Protein, Survivin, That Mediates Cytoprotection Against Ethanol-Induced Gastric Mucosal Injury Michael K. Jones*, Oscar R. Padilla

S1623

Dynamic Physiological and Molecular Changes in Gastric Ulcer Healing By Melatonin and Its Precursor, LTryprophan, in Rats Peter Konturek*, Tomasz Brzozowski, Gregor Burnat, Eckhart G. Hahn, Stanislaw Konturek

S1624

Mesenchymal Stem Cells Transplantation Accelerates Gastric Ulcer Healing in Rats Yujiro Hayashi*, Shingo Tsuji, Masahiko Tsujii, Tsutomu Nishida, Shuji Ishii, Hideki Iijima, Eiji Miyoshi, Sunao Kawano

S1625

Effect of Cj-42794, a Selective Antagonist of Prostaglandin E Receptor Subtype 4, On Ulcerogenic and Healing Responses in Rat Gastrointestinal Mucosa Koji Takeuchi*, Akiko Tanaka, Shinichi Kato, Eitaro Aihara, Kikuko Amagase

S1626

Effect of Lafutidine, a Histamine H2-Receptor Antagonist, On Delayed Healing of Gastric Lesions Induced By 5-Fluorouracil in Rats Yukiko Murashima*, Tohru Kotani, Kikuko Amagase, Shinichi Kato, Koji Takeuchi

S1627

Induction of Antral Ulcers By Alendronate, a NitrogenContaining Bisphosponate, in Rat Stomachs Yumi Ohashi*, Eitaro Aihara, Kikuko Amagase, Koji Takeuchi



Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC S1628

Polyamines Regulate c-Myc Translation Through Chk2Dependent HuR Phosphorylation in Intestinal Epithelial Cells Lan Liu*, Lan Xiao, Rao N. Jaladanki, Tongtong Zou, Jie Chen, Emily C. Bellavance, Myriam Gorospe, Jian-Ying Wang

S1629

Attenuation of Induced Heat Shock Proteins 70 and 25 in Gastric Surface Cells May Contribute to Mucosal Pathogenesis During Helicobacter pylori Infection JiHye Seo*, Masahiro Ohtani, Barry H. Rickman, James G. Fox, Susan J. Hagen

S1630

Vulnerability of Gastric Mucosa in Chronic Obstructive Pulmonary Disease Yoshiaki Takeuchi*, Jun-ichi Fuchikami

S1631

S1632

Target Molecules of Molecular Chaperone (HSP70) in Injured Gastric Mucosal Cells Are Cytoskeletal Myosin and Actin Yuko Izumi*, Michiro Otaka, Akihito Nagahara, Daisuke Asaoka, Naoto Sakamoto, Taro Osada, Masato Kawabe, Toshifumi Ohkusa, Masaru Odashima, Sumio Watanabe Maturation of Fundic Glandular Cells Are Markedly Altered in IL-10(-/-) Mice Masahiko Nakamura*, Hiderori Matsui, Hiroshi Serizawa, Nobuhiko Kamada, Toshifumi Hibi, Kanji Tsuchimoto

S1633

Raising Gastric Surface pH Does Not Protect Against Two-Photon Photodamage to the Mouse Gastric Epithelium Elise Demitrack*, Marshall H. Montrose

S1634

Alpha-Lipoic Acid Improves Acetic Acid-Induced Gastric Ulcer Healing in Rats Berna Karakoyun*, Meral Yuksel, Feriha Ercan, Can Erzik, Berrak C. Yegen

S1635

S1636

S1637

S1638

S1639

S1640

Gastroprotective Effect of Heme- Oxygenase-1/Biliverdin/ Co Pathway Against Ethanol- Induced Gastric Damage in Mice Antoniella S. Gomes, Samara J. Lima, Gemima G. Gadelha, Joyce A. Fonseca, Fernando Q. Cunha, Marcellus H. Souza* Evidence That Lipopolysaccharide (LPS) Injury to the Stomach May Be Mediated Directly Through Secretory Phospholipase a2 (sPLA2) and Lyso-Phosphatidylcholine (Lyso-PC) Elizabeth Dial*, Jim J. Romero, Duy M. Tran, Lenard M. Lichtenberger Hidrogen Sulfide (H2S) Is a Mediator of Gastric Mucosal Defense Against Ethanol Induced- Gastric Damage in Mice Jand Venes R. Medeiros, Roberto César P. Lima, Pedro Marcos G. Soares, André Luiz R. Barbosa, Antoniella S. Gomes, Fernando Q. Cunha, Marcellus H. Souza* Protective and Therapeutic Effects of Resveratrol, a Red Wine Polyphenol, On Acetic Acid-Induced Gastric Damage Ali Solmaz, Goksel Sener, Sule Cetinel, Meral Yuksel, Berrak C. Yegen*, Cumhur Yegen Biphasic Effect of Japanese Horseradish and Mustard On Gastric Ulcerogenic Responses in Rats Nahoko Izumi*, Shusaku Hayashi, Tetsuya Sugihara, Shinichi Kato, Koji Takeuchi Combination Therapy of Ecabet Sodium and Proton Pump Inhibitor (PPI) Compared with PPI Alone for Endoscopic Submucosal Dissection (ESD) -Induced Ulcer in Gastric Cancer: Prospective Randomized Study Shigenaga Matsui*, Masatoshi Kudo, Mumon Okada, Yutaka Asakuma, Tsutomu Ichikawa, Masanori Kawasaki

S1641



Pathogenic Importance of Cysteinyl Leukotrienes in Development of Gastric Lesions Induced By Ischemia/ Reperfusion in Mice Yoshino Komatsu*, Yuka Nakamori, Tohru Kotani, Koji Takeuchi

S1642

Cd2 Associated Protein Expression At Plasma Membrane Is Increased and Associates with Cell Junction Disruption After Extracellular Ca2+ Depletion in Rat Gastric Epithelia Harri Mustonen, Tuula Kiviluoto, Pauli A. Puolakkainen*, Eero O. Kivilaakso

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: GROWTH FACTORS AND SIGNAL TRANSDUCTION Participants will be able to: • Evaluate growth factors and signal transduction. S1643



EGFR Controls Flat Dysplastic ACF Development and Colon Cancer Progression in the Rat Azoxymethane Model Urszula Dougherty*, Amikar Sehdev, Sonia R. Cerda, Reba Mustafi, Nathaniel Little, Weihua Yuan, Sujatha Jagadeeswaran, Anusara Chumsangsri, Jorge-Shmuel Delgado, Maria Tretiakova, Loren Joseph, John Hart, Ezra Cohen, Lata M. Aluri, Alessandro Fichera, Marc Bissonnette

S1644

Epigenetic Downregulation of the Hedgehog Interacting Protein Gene Is Frequently Involved in Gastrointestinal Tumorigenesis Hiroyuki Yamamoto*, Hiroaki Taniguchi, Nobuki Miyamoto, Chie Miyamoto, Tadateru Maehata, Katsuhiko Nosho, Kentaro Yamashita, Yasushi Adachi, Yoshiaki Arimura, Fumio Itoh, Kohzoh Imai, Yasuhisa Shinomura

S1645

Epidermal Growth Factor Induces Expression of Protooncogene RBM3 Through p38 and erK Resulting in Increased COX-2 Expression Monica Draper*, Sripathi M. Sureban, Satish Ramalingam, Gopalan Natarajan, Courtney W. Houchen, Shrikant Anant

S1646

Growth Inhibitory Effects of Ursodeoxycholic Acid Through Negative Regulation of Receptor Tyrosine Kinase Activity in Human Colon Cancer Cells Rebecca A. Feldman*, Jesse D. Martinez

S1647

NF-κB Mediates Anti-Apoptotic Effect of Progastrin (PG) On Proximal (P) Colonic Crypts of Mice: Intracellular Co-Localization of PG with PG/Gastrin Receptor, AnnexinII (Anx-II), in P Colonic Crypts Shahid Umar*, Shubhashish Sarkar, Pomila Singh

S1648



Impact of PTEN Down-Regulation On Proliferation, Invasion and Differentiation of Human Colon Cancer Cells Marie-Josée Langlois*, Christine Jones, Nathalie Perreault, Nathalie Rivard

S1649

The Role of Prostaglandin E2 (PGE2) in Toll-Like Receptor-4 (TLR4)-Mediated Colitis-Associated Neoplasia Yasmin Hernandez*, Keith J. Breglio, Daisy E. Conduah, Anli Chen, Ruliang Xu, David Hsu, Ryan Ungaro, Maria T. Abreu, Masayuki Fukata

S1650

Regulation and Function of Amphiregulin in RASMediated Transformation of Intestinal Epithelial Cells Jinyi Shao, Hongmiao Sheng*

Denotes DDW Poster of Distinction

P-167

S U N D A Y MAY 18

POSTER SESSIONS—BASIC S1651

IL-6 Signalling Plays a Crucial Role in Repair of Gastric Mucosa After Ulceration By Regulation of the Reg and MMP Gene Families Louise M. Judd*, Meegan Howlett, Meera Ulaganathan, Andrew S. Giraud

S1652

Inhibition of CUGBP2 By Prostaglandin E2 Suppresses Radiation-Mediated Mitotic Catastrophe in Colon Cancer Cells Gopalan Natarajan*, Satish Ramalingam, Ilangovan Ramachandran, Randal May, Lurdes Queimado, Courtney W. Houchen, Shrikant Anant

S1653

S1654

Sulindac Metabolites (SMs) Inhibit Epidermal Growth Factor Receptor (EGFR) Signaling and Induce Lysosomal/Proteasomal Degradation of EGFR Heather A. Pangburn*, Pamela L. Rice, Dennis Ahnen Differential Regulation of the PI3K/AKT Pathway By the Low- and High-Affinity State of the CCKA Receptor Marc J. Berna*, Jose Tapia, Veronica Sancho, Michelle Thill, Andrea Pace, Karl M. Hoffmann, Robert T. Jensen

AGA Institute Poster Session 8:00 AM - 5:00 PM

S1660



Activation of the Extracellular Calcium-Sensing Receptor (CaSR) Stimulates Proglucagon Transcription and GLP-1 Secretion from Murine Enteroendocrine Cells But Inhibits GLP-1 Secretion from Murine Hypothalamic Neurons Robert Vanner*, Ivan I. Pacheco, R. John MacLeod

S1661

Alanyl-Glutamine (Ala-Gln) Transactivates Epidermal Growth Factor Receptor (EGFR) to Stimulate MitogenActivated Protein Kinase (MAPK) Activity and Intestinal Epithelial Cell Growth Sean R. Moore*, Stuart Hobbs, Mark R. Frey, Richard L. Guerrant, D. Brent Polk

S1662

In Vitro Pharmacological Characterization of a Novel Motilin Receptor Antagonist (TZP-201) in Colonic Smooth Muscle from the Shrew (Suncus Marinus) Kalina M. Venkova*, Helmut Thomas, Graeme L. Fraser, Beverley Greenwood-Van Meerveld

S1663

Enhanced Ghrelin Production and Secretion and Reduced Expression of Ghrelin Receptor in Rat Stomach with Delayed Gastric Emptying Eisuke Iwasaki*, Hidekazu Suzuki, Tatsuhiro Masaoka, Toshihiro Nishizawa, Tetsufumi Takahashi, Hitoshi Tsugawa, Yoshimasa Saito, Sachiko Suzuki, Hiroshi Hosoda, Kenji Kangawa, Toshifumi Hibi

S1664

Imbalances of 5-HT1a and 2C Receptor Gene Expression in CNS Mediate Aggravated Anorexia in Advanced AgeMice Under Social Isolated Stress Shuichi Muto*, Hiroshi Takeda, Tomohisa Hattori, Chiharu Sadakane, Masahiro Asaka

S1665

Attenuation of Inhibitory Responses to Colorectal Distension Within the Thalamus By Alosetron: Role of 5-HT2B vs 5-HT3 Receptors Amanda J. Woods, David C. Bulmer*, Martyn L. Evans, Andrew Lowe, Lloyd J. Gregory, Martin J. Gunthorpe, Kevin Lee, Qasim Aziz, Steven C. Williams, Wendy J. Winchester

S1666

Identification and Characterization of Novel Rat CRF Receptor Type 1 Isoforms in the Gastrointestinal Tract Shuping V. Wu*, Meisheng Jiang, Million Mulugeta, Jiunu J. Lai, Pu-Qing Yuan, Yvette Tache

S1667

A-Transducin, a Signaling Molecule of the Chemoreceptive Cascade, Is Expressed in Endocrine and Non-Endocrine Cells of the Pig Gastrointestinal Mucosa Roberto De Giorgio*, Maurizio Mazzoni, Giovanna LalattaCosterbosa, Roberto Chiocchetti, Giovanni Barbara, Paolo Bosi, Paolo Gionchetti, Fernando Rizzello, Roberto Corinaldesi, Vincenzo Stanghellini, Massimo Campieri, Enrique Rozengurt, Catia Sternini, Paolo Clavenzani

S1668

Expression and Functional Impact of KENG Genes in the Murine Colon James D. Moffatt*, Thomas Jepps, Susumu Ohya, Iain Greenwood

S1669

Expression of Progastrin/Gastrin Receptor, Annexin-II, Is Required for Binding and Internalization of PG in Intestinal Epithelial Cells (IEC-18): Functional Correlates Shubhashish Sarkar*, Pomila Singh

Sails Pavilion San Diego Convention Center

Sponsored by: Growth, Development & Aging

AGING: CHANGES IN GI FUNCTION AND PHYSIOLOGY

S U N D A Y

Participants will be able to: • Review the effects of aging on GI function and physiology. S1655

Mechanistic Roles of cAMP, Protein Kinase a and PCREB in Aging-Related Impairment of Angiogenesis: Implications for Delayed Healing of Aging Gut. Wanjun Bae*, Amrita Ahluwalia, Andrzej Tarnawski

S1656

Age Related Loss of Myenteric Neurons and Choline Acetyl Transferase-Positive Neurons in the Normal Human Colon Cheryl E. Bernard*, Simon J. Gibbons, Philip Schmalz, David R. Linden, Robert R. Cima, Eric J. Dozois, David W. Larson, Michael Camilleri, Alan R. Zinsmeister, Gareth A. Hicks, Gianrico Farrugia

MAY 18

S1657

Isolated Lymphoid Follicle Formation Is Augmented and Aberrant with Aging Conway C. Huang*, Keely McDonald, Caihong Wang, Rodney D. Newberry

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

HORMONES & RECEPTORS: RECEPTORS FUNCTION AND REGULATION Participants will be able to: • Learn about receptors expression, function and regulation. S1658



Bitter Taste Receptor Agonists Denatonium Benzoate (DB) and Phenylthiocarbamide (PTC) Activate ERK Pathway Through Different Mechanisms in Enteroendocrine STC-1 Cells Monica C. Chen*, Catia Sternini, Enrique Rozengurt

S1659

TNF-α Inhibits Human Intestinal NaPi-Iib Gene Expression in Caco2 Cells Via Epidermal Growth Factor Receptor Activation Huacong Chen*, Hua Xu, Jiali Dong, Jing Li, Fayez K. Ghishan

 P-168



Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

S1681



Establishment of a Mouse Model to Study the In Vivo Regulation of Histidine Decarboxylase (HDC) Gene Expression Walden Ai, Xiangdong Yang*, Shigeo Takaishi, Benjamin Shykind, Frédéric Marrache, Shuiping Tu, Kelly S. Betz, Timothy C. Wang

S1682

Role of the Gasotransmitter Hydrogen Sulfide in Modulation of Contractile Function in Longitudinal Muscle of Rat Jejunum Michael G. Sarr, Michael S. Kasparek*, David R. Linden

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

HORMONES AND RECEPTORS IN GASTROINTESTINAL MOTILITY S1670



The Identification of Peroxisome Proliferator-Activated Receptor Alpha-Independent Effects of Oleoylethanolamide On Intestinal Transit in Mice. Nina L. Cluny*, Catherine M. Keenan, Beat Lutz, Daniele Piomelli, Keith A. Sharkey

S1671



The Role of the 5-HT2c Receptor in Tumor-Induced Anorexia and Gastrointestinal Motility in Rats Haruka Amitani*, Akihiro Asakawa, Marie Sameshima, Shinya Kojima, Mizuki Hayashi, Naoki Fujitsuka, Akio Inui

S1672

TD-8954 Is a Highly Potent and Selective 5-HT4 Receptor Agonist with Potential Utility in Disorders of Reduced Gastrointestinal Motility David T. Beattie*, Ross G. Vickery, Scott R. Armstrong, Anna Ropenga, Alan W. Cuthbert, Patrick P. Humphrey

S1673

17-Beta Estradiol Attenuates Delayed Gastric Emptying and Decreased Neuronal Nitric Oxide Synthase Alpha (nNOSα) Expression in Female Diabetic Rats Pandu R. Gangula*, Robert E. Garfield, Pankaj J. Pasricha

S1674

Influence of Ghrelin On Gastric Accommodation and Meal-Induced Satiety in Man Daphne C. Ang*, Heleen Nicolai, Rita Vos, Pieter Vanden Berghe, Daniel Sifrim, Kostas Mimidis, Filiz Akyuz, Inge Depoortere, Theo L. Peeters, Jozef Janssens, Jan F. Tack

S1675

Expression of Myosin Light Chain (MLC) Phosphatase Activator (Telokin) and Inhibitor (CPI-17) Determines the Magnitude of Smooth Muscle Relaxation and Contraction, Respectively, in Different Regions of the Stomach Sunila Mahavadi*, Wimolpak Sriwai, Karnam S. Murthy

S1676

Effect of a Protein Preload On Gastric Emptying and Glycemia in Type 2 Diabetes Jing Ma*, Julie E. Stevens, Anne F. Maddox, Jane Bowen, Karen L. Jones, Judith Wishart, Michael Horowitz, Peter Clifton, Chris Rayner

S1677

Endothelin Causes Relaxation of Guinea Pig Internal Anal Sphincter Through Interaction with Endothelin a (ETA) Receptor Shih-Che Huang

S1678

Comparison of Ghrelin and Motilin Effects On Fasted Gastric Tone and Gastric Accommodation to Meal in Conscious Dogs Ludovic Perrot, Melanie Buchi, Marie-Laure RouzadeDominguez*

S1679

5-HT7 Receptors Mediate Colonic Accommodation in Conscious Rats Vicente Martinez*, Magnus Lindgreen

S1680

Up-Regulation of Peptide YY (PYY) By Abdominal Surgery and Expression and Cellular Localization of Y2 Receptor in Mouse Colon: Implications in Postoperative Ileus Pu-Qing Yuan*, Lixin Wang, Mulugeta Million, Guillaume Goucerol, Shuping V. Wu, Yvette Tache

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

HORMONES AND RECEPTORS: SIGNAL TRANSDUCTION Participants will be able to: • Review recent advances in signal transduction in differentiated cells and cell lines. S1683

Regulation of Constitutive and IL-1β-Induced RGS4 Expression in Smooth Muscle Cells Is Mediated Via MEKK1-JNK-Ap1 Pathway Wenhui Hu*, Fang Li, Wu Deng, Karnam S. Murthy

S1684

Enhanced or Disrupted GLP-2 Receptor Signaling Fails to Modify Growth or Survival of Murine or Human Intestinal Tumor Cells Jacqueline Koehler*, William Harper, Bernardo Yusta, Daniel J. Drucker

S1685

PAK1 Interacts with β-Catenin and Is Required for the Regulation of the β-Catenin Signalling Pathway By Gastrins Hong He, Arthur Shulkes, Graham S. Baldwin*

S1686



Sustained Contraction of Smooth Muscle By PAR1 Receptors Is Selectively Mediated By RhoA/PKC/Cpi-17 Pathway: Evidence That Co-Activation of the RhoA/Rho Kinase/Mypt1 Pathway Is Suppressed By PKA Released from IκBα Wimolpak Sriwai*, Sunila Mahavadi, Fang Li, Wenhui Hu, Karnam S. Murthy

S1687



Serotonin Transporter Function and Expression Are UpRegulated By a PKA-Independent cAMP Signaling Pathway in Intestinal Epithelial Cells Brigitte Lavoie*, Cristen Pantano, Alan K. Howe, Gary M. Mawe

S1688



Kidins220 Phosphorylation By PKD Is Required in the Regulation of Neurotensin Secretion in the BON Human Endocrine Cell Line Jing Li*, Courtney M. Townsend, B. M. Evers

S1689



Basal Prostaglandin Levels Are Necessary for Pyk2 Expression and Constitutive FAK Tyr-397 Phosphorylation in Intestinal Epithelial Cells Steven S. Wu*, H. Pham, Romina Vincenti, Enrique Rozengurt, Lee W. Slice

S1690

Pyk2-Mediated, Direct Upstream Phosphorylation of FAK Tyr397 As a Novel Initiating Event for FAK Signal Transduction Responses to Prostaglandins in Intestinal Epithelial Cells Richard T. Waldron*, Romina Vincenti, Hung Pham, Steven S. Wu, Enrique Rozengurt, Lee W. Slice

Denotes DDW Poster of Distinction

P-169

S U N D A Y MAY 18

POSTER SESSIONS—BASIC S1691

Endogenous Protein Kinase D Contributes to GqCoupled Receptor Induction of DNA Synthesis in Swiss 3T3 Cells James Sinnett-Smith*, Rodrigo O. Jacamo, Robert K. Kui, Yunzu M. Wang, Enrique Rozengurt

S1692

Cyclic-AMP Accelerates Carbachol- and CaeruleinStimulated Calcium Waves in Pancreatic Acinar Cells Ahsan U. Shah, Wayne M. Grant, Sahibzada U. Latif, Alexander Park, Sohail Z. Husain*

S1693

Translocation of Phosphorylated Protein Kinase D (PKD) to the Plasma Membrane and Nucleus of Agonist Stimulated LEC18 and IEC6 Cells Monitored By Quantum Dot Conjugated Secondary Antibodies. Steven H. Young*, James Sinnett-Smith, Enrique Rozengurt

S1694

S1695



Annexin-II Mediates Potent Growth Factor Effects of Full Length Progastrin On Human Embryonic Kidney Cells (HEK293): Activation of NFkB/β-Catenin and UpRegulation of Target Gene Proteins Shubhashish Sarkar*, Pomila Singh Inhibitory Phosphorylation of Soluble Guanylyl Cyclase Induced By Cannabinoid CB1 Agonist Is Mediated By CSRC Kinase and Dependent On Internalization of Cb1 Receptors Via GRK5: A Mechanism for Inhibition of Smooth Muscle Relaxation By Cannabinoids Sunila Mahavadi*, Karnam S. Murthy

AGA Institute Poster Session 8:00 AM - 5:00 PM

S U N D A Y MAY 18

S1702

Essential Role of HSP70 to Prevent AOM/DSS Induced Inflammatory Colon Cancer Yun Tao*, Lev Lichtenstein, John Hart, Marc Bissonnette, Eugene B. Chang

S1703

Distinct Role of Toll-Like Receptor 2 (TLR 2) in Development of Murine Colitis-Associated Colorectal Neoplasia Jae Geun Hyun*, Yasmin Hernandez, David Hsu, Junske Maki, Keith J. Breglio, Daisy E. Conduah, Anli Chen, Ruliang Xu, Maria T. Abreu, Masayuki Fukata

S1704

Fundamental Difference in Hemopoietic Growth Factors (Flt3l, GM-CSF) On Experimental Mouse Colitis and the Innate Immune Response Konrad Aden*, Satheesh K. Sainathan, Kumar S. Bishnupuri, Qizhi Luo, Stefan Schreiber, Brian K. Dieckgraefe

S1705

In Vivo Imaging of a Probiotic-Mediated Regulatory T Cell Response Following Adoptive Transfer Caitlin O'Mahony*, Paul Scully, David O'Mahony, Sharon Murphy, Frances O'Brien, Anne Lyons, Barry Kiely, Fergus Shanahan, Liam O'Mahony

S1706

Colitis Immunoregulation By CD8+ T Cells Is Induced By B Cell Peptide Antigen Presentation and Requires T Cell Cytotoxicity Bo Wei*, Michael McPherson, Sarah N. Brewer, Daisuke Fujiwara, Jonathan Braun

S1707

Conventional Dendritic Cells Regulate the Outcome of Colonic Inflammation Independently of T Cells Kazumichi Abe*, Kim Phung Nguyen, Kyoko Katakura, Maripat Corr, Jongdae Lee, Lars Eckmann, Hiromasa Ohira, Eyal Raz

S1708

A Crucial Regulatory Role of Vav1 in Chronic Intestinal Inflammation and Colitis Associated Colon Cancer Imke Atreya*, Christoph Becker, Victor Tybulevicz, Peter R. Galle, Markus F. Neurath

S1709

Enteral Formula Feeding Causes Acute Intestinal Dysfunction and Inflammation in Preterm Pigs During Development of Necrotizing Enterocolitis Jayda L. Siggers, Richard H. Siggers, Kerstin Skovgaard, Thomas Thymann, Mette Boye, Per T. Sangild*

S1710

Low Dietary Iron Inhibits Chronic Experimental Ileitis and Attenuates Endoplasmic Reticulum Stress Responses in Intestinal Epithelial Cells Tanja V. Werner*, Klaus Schuemann, Dirk Haller

S1711

KSR Is Protective Against IL-10-Mediated Colitis Jeremy A. Goettel*, Mary Kay Washington, D. Brent Polk

S1712

CD14 Is a Protective Factor in Experimental IBD Maike F. de Buhr, Hans J. Hedrich, Astrid M. Westendorf, Florian Obermeier, Nils-Holger Zschemisch, Jan Buer, Dirk Bumann, Andre Bleich*

S1713

Epithelial Hedgehog Signals Modulate the Inflammatory Response of the Intestinal Lamina Propria William J. Zacharias*, Charles W. Lees, John Y. Kao, Xing Li, Jack Satsangi, Deborah L. Gumucio

S1714

MTG16 Contributes to Enterocyte Integrity in Response to Injury Christopher S. Williams*, Elizabeth I. Harris, Alastair J. Watson, Kay Washington, Michael E. Engel, Amanda D. Williams, Isabel Moreno-Miralles, Scott W. Hiebert

S1715

Mast Cell Induced Bacterial Translocation in the Pathogenesis of Post-Operative Ileus Studied in a Mouse Model Susanne A. Snoek*, Guy E. Boeckxstaens, Olaf Welting, Oana I. Stanisor, Cathy Cailotto, Rene M. van den Wijngaard, Wouter de Jonge

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

ANIMAL MODELS: MECHANISMS OF INTESTINAL INFLAMMATION Participants will be able to: • Understand mechanisms of intestinal inflammation. S1696



Terminal Ileum Resection and Re-Anastomosis Results in a Colonic Bacterial Profile in the Neo-Terminal Ileum and An Antigen Driven Immune Response Anna M. Borowiec*, Rae Foshaug, Le Luo Guan, Sarah M. MacFarlane, Beate C. Sydora, Richard Fedorak

S1697



Tweak/Fn14 Pathway: Role in the Intestinal Inflammation and Tissue Repair Taeko Dohi*, Anna Borodovsky, Rei Kawashima, Ping Wu, Yuki I. Kawamura, Linda C. Burkly

S1698



Increased Expression of Epithelial TLR5 and Activation of the TLR5 Pathway Leads to Epithelial Barrier Dysfunction in Experimental Crohn's Disease Ruo Jia, Xiao Ming Wang, Li-Guo Jia, Fabio Cominelli, Theresa T. Pizarro*

S1699



Thymic Stromal Lymphopoietin (TSLP) Is Critical for Food Allergy and Promotes Th2 Skewing By Gastrointestinal Dendritic Cells Ana B. Blazquez*, Adina Kay K. Knight, M. Cecilia Berin

S1700

Smurf2 Activity in T Lymphocytes Protects Mice from Experimental Colon Cancer Heike Dornhoff*, Christoph Becker, Peter R. Galle, Markus F. Neurath

S1701

A Crucial Role of Rorgamma Expressing TH17 Cells in Chronic Intestinal Inflammation Moritz Leppkes*, Christoph Becker, Stefan J. Wirtz, Ivaylo I. Ivanov, Clemens Neufert, Andrew J. Murphy, David Valenzuela, George Yancopoulos, Erin Nesbitt, Peter R. Galle, Dan R. Littman, Markus F. Neurath

P-170

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC S1716

A Positive Role of CHOP, a Transcription Factor Involved in ER Stress Response, in Development of Inflammatory Bowel Disease (IBD)-Related Experimental Colitis Takushi Namba*, Tohru Mizushima

S1717

Adiponectin Deficiency Does Not Affect Development and Progression of Spontaneous Colitis in IL-10 Ko Mice Maria Pini*, Melissa E. Gove, Raja Fayad, Joseph A. Sennello, Robert J. Cabay, Lawrence Chan, Giamila Fantuzzi

S1718

S1719

Intestinal Macrophages Recruited By MCP-1 Negatively Regulate Intestinal Inflammation Via Production of AntiInflammatory Cytokine IL-10 Yasuhiro Takada*, Tadakazu Hisamatsu, Nobuhiko Kamada, Riko Saito, Taku Kobayashi, Hiroshi Chinen, Susumu Okamoto, Toshifumi Hibi Regulation of Gut Inflammation and TH17 Cell Response By Interleukin-21 Daniele Fina*, Massimiliano Sarra, Massimo C. Fantini, Angelamaria Rizzo, Roberta Caruso, Flavio Caprioli, Carmine Stolfi, Iris Cardolini, Monica Boirivant, Francesco Pallone, Thomas T. MacDonald, Giovanni Monteleone

S1720

Activation of Innate Immunity with a TLR 7 Agonist, Imiquimod, Ameliorates Acute DSS Colitis Satheesh K. Sainathan*, Konrad Aden, Kumar S. Bishnupuri, Qizhi Luo, Courtney W. Houchen, Shrikant Anant, Brian K. Dieckgraefe

S1721

T Cells Contribute to the Intestinal Fibrosis Induced By Chronic Salmonella Infection in Mice Guntram A. Grassl*, Yanet Valdez, Kirk S. Bergstrom, Bruce A. Vallance, B. Brett Finlay

S1722

S1723

Enterotoxigenic Bacteroides fragilis Induce E-Cadherin Shedding and TH17 Response in C57BL/6 Mice Ki-Jong Rhee*, Shaoguang Wu, Shervin Rabizadeh, XinQun Wu, Franck Housseau, Drew M. Pardoll, Baktiar O. Karim, Cynthia Sears The Role of β3-Integrin On Bone Marrow-Derived Cells in Inflammatory Bowel Diseases Stefanie Schier*, Alan Watson, Kairbaan Hodivala-Dilke, Nicholas A. Wright

S1724

Spontaneous Distal Colitis in NHE3-Deficient Mice Daniel Laubitz*, Aiping Bai, Claire B. Larmonier, Monica T. Midura-Kiela, Robert D. Thurston, Pawel R. Kiela, Fayez K. Ghishan

S1725

Atonal Homolog 1 (Atoh1) Regulates Susceptibility to Experimental Colitis in Mice Bella Zeisler*, I-Yuan Joseph Chang, Noah F. Shroyer

S1726

Cxcr2-Targeted Chemokines Are Critical Regulators of Host Defense Against the Attaching/Effecing LesionForming Pathogen Citrobacter rodentium Martina E. Spehlmann*, Sara M. Dann, Elaine Hanson, Petr Hruz, Lars Eckmann

S1727

DC Subtypes in the Colon and Their Role in TNBS Colitis Colin de Haar*, Pieter van Lierop, Dicky LindenberghKortleve, Mirjam Kool, Leonie S. van Rijt, Bart Lambrecht, Edward Nieuwenhuis, Janneke Samsom

S1728

Bacterial Translocation Induced By Chronic Stress During the Remission Phase of Rat Model of Enteritis: A Possible Risk of Inflammatory Reactivation? Esther Jorge*, Patri Vergara, Maite Martin

S1729

Upregulation of HIF-1α Is Associated with Augmented Rho-Kinase-Mediated Contraction of Ileal Smooth Muscle Following Exposure to Clostridium difficile Toxins in a Mouse Ileal Loop Model Eikichi Ihara, Simon A. Hirota*, Paul L. Beck, Justin A. MacDonald

S1730

Display of Self Antigens By Lymph Node Stromal Cells Contributes to CD8 T Cell Tolerance Khashayarsha Khazaie*, Fay Magnusson

S1731

Tolerance of Toll-Like Receptor 4 Mediated Signaling Pathway Protects Mice from Experimental Colitis Keietsu Saito*, Kyoko Katakura, Kaori Kanno, Ryoma Suzuki, Hiromasa Ohira

S1732

Elafin Is Protective Against the Development of Colitis in IBD Murine Models Jean-Michel Sallenave, Camila S. Dale, Viviane Balloy, Michel Chignard, Nathalie Vergnolle*

S1733

Toll-Interacting Protein (Tollip) Increases the Severity of Acute Colitis Christopher Waterhouse*, Donna-Marie McCafferty, Paul Kubes

S1734

Apolipoprotein C3 Is a Novel Binding Partner of CD1D and Regulates CD1D-Restricted Immunopathologies Arthur Kaser*, Zhangguo Chen, T Jake Liang, Hyun S. Kim, David E. Cohen, Richard S. Blumberg



AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

ANIMAL MODELS: PRE-CLINICAL TREATMENT OF INTESTINAL INFLAMMATION Participants will be able to: • Understand developing new therapies of intestinal inflammation, as demonstrated in animal models. S1735



Oral Administration of Amniotic Fluid Reduces Necrotizing Enterocolitis in Preterm Pigs Jayda L. Siggers, Richard H. Siggers, Kerstin Skovgaard, Mette Schmidt, Hanne K. Moeller, Mette Boye, Per T. Sangild*

S1736

Minimal Enteral Nutrition Diet-Dependently Reduces Severity of Necrotizing Enterocolitis in Preterm Pigs Thomas Thymann, Malene S. Cilieborg, Randal K. Buddington, Stine B. Bering, Per T. Sangild*

S1737



Drugs Inhibiting Endocannabinoid Degradation Protect Against Experimental Colitis in Mice Martin Storr*, Catherine M. Keenan, Hong Zhang, Kamala D. Patel, Keith A. Sharkey

S1738

Luminal Antioxidants Enhance the Effects of mesalamine in the Treatment of Chemically Induced Colitis in Rats Hanumantha R. Ancha*, Ravi R. Kurella, Christine C. McKimmey, Stan A. Lightfoot, Richard F. Harty

S1739

Bilirubin Suppresses Intestinal Inflammation in the DSS Model of Acute Colitis in Mice Tammy L. Kindel*, Pavitra Keshavan, Darcey Smith, Stephen D. Zucker

S1740

The Effects of Rapamycin in the TNBS Mouse Model of Inflammatory Bowel Disease Gary C. Bruns*, Dave Cody, Russell J. Sheldon, George Zhang

Denotes DDW Poster of Distinction

P-171

S U N D A Y MAY 18

POSTER SESSIONS—BASIC S1741

S U N D A Y

Milk Fat Globule EGF-8 Attenuates Intestinal Inflammation in Murine Experimental Colitis Via Inhibition of NF-κB Activation Shunji Ishihara*, Md M. Aziz, Mohammad A. Rumi, Yoshiyuki Mishima, Naoki Oshima, Ichiro Moriyama, Chikara Kadota, Yong-Yu Li, Aya Ohtani, Akihiko Oka, Rahman B. Farzana, Norihisa Ishimura, Yasunori Kadowaki, Yuji Amano, Yoshikazu Kinoshita

S1755

Oxytocin Treatment Alleviates Stress-Aggravated Colitis By a Receptor-Dependent Mechanism Sertan Hancioglu, Emre Sener, Can Uner, Merve Kilic, Sule Cetinel, Goksel Sener*, Berrak C. Yegen

S1756

Subcutaneous Adipose Tissue-Derived Stem Cells Facilitate Colonic Mucosal Recovery from 2, 4, 6Trinitrobenzene Sulfonic Acid (TNBS)-Induced Colitis in Rats Yugo Ando*, Muneo Inaba, Yutaku Sakaguchi, Masanobu Tsuda, Mariko Omae, Guo Ke Quan, Susumu Ikehara, Kazuichi Okazaki

S1742

CCL2(pm) As a Therapeutic Agent in Inflammatory Bowel Disease Models in Mice Nitsan Maharshak*, Gili Hart, Idit Shachar

S1743

Efficacy of a Sphingosine Kinase Inhibitor in the Treatment of 2,4,6-Trinitrobenezenesulfonic Acid (TNBS)-Induced Colitis in Rats Lynn W. Maines*, Leo R. Fitzpatrick, Cecelia Green, Charles D. Smith

S1757

ApoE-Mimetic Peptide COG112 Ameliorates Dextran Sulfate Sodium Colitis Kshipra Singh*, Rupesh Chaturvedi, Daniel P. Barry, Mohammad Asim, Roxanne J. Wadia, Nuruddeen D. Lewis, Mary Kay Washington, Michael P. Vitek, Keith T. Wilson

S1744

Il10 and Il4 Synergize to Inhibit Il17 Production in Mice Colonized with the Intestinal Helminth Heligmosomoides polygyrus Ahmed Metwali, John Leung, M.Nedim Ince, Sarah Winckler, Arthur Blum, Tommy Setiawan, Joseph F. Urban, Joel V. Weinstock, David E. Elliott*

S1758

Halofuginone Treatment Ameliorates Oxidative Damage By a Neutrophil-Dependent Mechanism in Experimental Colitis Berna Karakoyun*, Meral Yuksel, Feriha Ercan, Berrak C. Yegen, Isil Isik

S1759

S1745

Anti-Inflammatory Effects of Opc-6535; PDE4 May Be a New Therapeutic Target in Inflammatory Bowel Disease Hitoshi Ichikawa*, Susumu Okamoto, Nobuhiko Kamada, Taku Kobayashi, Tetsurou Takayama, Tadakazu Hisamatsu, Toshifumi Hibi

Nafamostat Mesilate, a Synthetic Serine ProteaseInhibiting Agent, Attenuate Dextran Sulfate SodiumInduced Colitis in Mice Young-Mi Lee*, Eun Young Cho, Ki Jung Yun, Suck Chei Choi, Dae-Ki Kim

S1746

IL-23 Is Only Partially Involved in Promoting Chronic Intestinal Inflammation in the Dextran Sodium Sulphate-Induced Colitis Model Hidetoshi Takedatsu*, Kathrin S. Michelsen, Carol J. Landers, Lisa S. Thomas, Deepti Dhall, Stephan R. Targan

AGA Institute Poster Session 8:00 AM - 5:00 PM

Rsolvin E1, An Endogenous Lipid Mediator Derived from Eicosapentaenoic Acid Protects in Dextran Sulfate Sodium Induced Colitis Tsukasa Ishida*, Masaru Yoshida, Yousuke Nishitani, Izumi Kure, Yuki Shiomi, Makoto Arita, Charles N. Serhan, Takeshi Azuma

INTESTINAL CELL AND MOLECULAR BIOLOGY

S1747

MAY 18

Sails Pavilion San Diego Convention Center

Sponsored by: Intestinal Disorders

Participants will be able to: • Evaluate recent research in the intestinal cell and molecular biology. S1760



Involvement of V1b Receptor in the Development of Experimental Colitis in Mice Laurent Ferrier*, Eric Gaultier, Claudine Serradeil-Le Gal, Marc Pascal, Lionel Bueno

TNF-α Represses the NHE2 Promoter Activity Through NF-κB Transcription Factor in C2bbe1 Cells Md Ruhul Amin*, Pradeep K. Dudeja, Krishnamurthy Ramaswamy, Jaleh Malakooti

S1761

S1750

Rodent Video Endoscopy and Biopsy: A New Method for the Development of Novel Inflammatory Bowel Disease Therapies Gregory D. Lyng*, Chris Stevens, Gavin Gordon, Brynmor A. Watkins, Stephen T. Sonis

Coordinated Phase Shift of Intestinal Clock Gene and Sodium Glucose Co-Transporter (SGLT1) Rhythms with Switched Feeding Anita Balakrishnan*, Adam T. Stearns, Stanley W. Ashley, Ali Tavakkolizadeh

S1762

Altered Promoter DNA Methylation Regulates Human NHE2 Gene Transcription Eleanor Murray, Ying x. Zhu, Pradeep K. Dudeja, Krishnamurthy Ramaswamy, Jaleh Malakooti*

S1763

The Role of Neural and Local Signals in Coordinating Intestinal Clocks John S. Young*, Adam T. Stearns, Anita Balakrishnan, David B. Rhoads, Stanley W. Ashley, Ali Tavakkolizadeh

S1764

Bile Acid Regulation of Intestinal CFTR Is Associated with HNF4α, HNF1α and Hdac7 Mediated Histone Modification Thankam Paul*, Junling Wang, Martin Walsh, Neal S. LeLeiko, SiDe Li

S1767

Polyamines Modulate the Stability of JunD mRNA Through RNA-Binding Proteins HuR and AUF1 in Intestinal Epithelial Cells Tongtong Zou*, Lan Xiao, Rao N. Jaladanki, Lan Liu, Jie Chen, Douglas J. Turner, Myriam Gorospe, Jian-Ying Wang

S1748

S1751

S1752

S1753

S1754

P-172

Establishment of Local Gene Delivery Approach Capable of Targeting Inflamed Mucosa for Activating Innate Responses Ken Sugimoto*, Yasuyo Shimomura, Atsuhiro Ogawa, Akira Andoh, Atul K. Bhan, Ramnik J. Xavier, Richard S. Blumberg, Atsushi Mizoguchi Amelioration of TNBS-Induced Colitis By Marine Glycosaminoglycans Celso Belmiro, Morgana T. Castelo-Branco, Celeste C. Elia, Alberto Schanaider, Mauro S. Pavao, Heitor Souza* EGCG, a Major Component of Green Tea Catechins Attenuates Inflammatory Responses in Two Different Mouse Colitis Models Sabine Westphal*, Markus Brueckner, Wolfram W. Domschke, Torsten F. Kucharzik, Andreas Luegering Betulinic Acid Treatment Ameliorates Oxidative Colonic Injury in Rats Via Its Antioxidant Activity Ozer A. Sehirli, Goksel Sener*, Emre Sener, Riza Kardas, Emel Eksioglu-Demiralp, Sule Cetinel, Berrak C. Yegen



Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC S1768



Mapping the Intracellular Itinerary of FcRn-Dependent IgG Transport Across Mucosal Surfaces Salit Tzaban*, Elizabeth H. Yen, Jessica Wagner, James R. Goldenring, Richard S. Blumberg, Wayne I. Lencer

AGA Institute Poster Session 8:00 AM - 5:00 PM

S1769

Transferrin Is An Important Growth Factor for TissueEngineered Intestinal Mucosa Beatrix Wulkersdorfer*, Vatche G. Agopian, Audrey Ahn, James Dunn, Ben Wu, Matthias G. Stelzner

Sponsored by: Liver & Biliary

S1770

S1771

S1772

S1773

S1774

 S1775

S1777

S1778

S1779

S1780

S1781



Proteome of the Small Intestinal Brush Border of the NHERF1 Knock Out Mouse: Up Regulation of Transporters and Pro-Proliferation Molecules Mark Donowitz*, Siddharth Singh, Farah F. Salahuddin, Boris M. Hogema, Marjan Gucek, Robert N. Cole, Yueping Chen, Rakhilya Murtazina, Nicholas C. Zachos, Olga Kovbasnjuk, Lynne A. Lapierre, Nellie Broere, James R. Goldenring, Hugo deJonge, Xuhang Li Regulated Exocytosis and Fusion of Vesicle Associated CFTR to the Apical Plasma Membrane of the Intestine Is Mediated By the Snare Protein Syntaxin-3 Nadia Ameen*, Anne Collaco Phosphorylation-Dependent Interaction of Intermediate Filament Keratins with Non-Muscle Myosin II-C in Human Colonic Epithelial Cells Guo-Zhong Tao*, Diana M. Toivola, Qin Zhou, Yuan Tao, Bishr Omary Identification of microRNA Expressed in Duodenal and Gastric Mucosa, and Modulation By the Duodenal Ulcerogen Cysteamine Longchuan Chen*, Xiaoming Deng, Tetyana Khomenko, Sandor Szabo JunD Represses Importin-α1 Transcription Through Its Proximal Promoter Region and Regulates Subcellular Localization of RNA-Binding Protein HuR in Intestinal Epithelial Cells Jie Chen*, Tongtong Zou, Rao N. Jaladanki, Lan Liu, Lan Xiao, Emily Bellavance, Tingxi Yu, Douglas J. Turner, JianYing Wang Reciprocal Expression of Calcium-Sensing Receptor (CaSR) and Ror2 During Colon Cancer Progression: A New Role for Dkk1 Maria Westerhoff*, Ivan I. Pacheco, R. John MacLeod, Jerrold R. Turner Protein Kinase D3 Plays a Pro-Apoptotic Role in Oxidative Stress-Induced Apoptosis in Intestinal Epithelial Cells Jun Song*, Jing Li, B. M. Evers, Dai H. Chung Cigarette Smoke Extract Protects Intestinal- and T-Cells Against Death-Receptor- and Oxidative Stress Induced Apoptosis: An Explanation for Dichotomal Effects of Smoking On Ulcerative Colitis and Crohn's Disease? Elise M. van der Logt*, Klaas-Nico Faber, Tjasso Blokzijl, Dirk-Jan Slebos, Maikel P. Peppelenbosch, Gerard Dijkstra Inflammation Modulates the Recruitment of Signaling Pathways Downstream of the EGF Receptor in Colonic Epithelial Cells Gisela Paul*, Declan F. McCole, Kim E. Barrett Alteration of Dopaminergic Markers in Gastrointestinal Tract of Different Rodent Model of Parkinson's Disease Yue-min Tian, Xin Chen, Xiao-Hui Zhang, Hong Xue, Li-Fei Zheng, Ning Yang, Jin-xia Zhu* Impaired Axial Epithelial Differentiation in Ulcerative Colitis in Remission Jenny Gustafsson*, Henrik Sjövall

Sails Pavilion San Diego Convention Center

CLINICAL BILIARY TRACT DISORDERS Participants will be able to: • Understand the associations and newer approaches to clinical biliary tract disease. S1782

Health Related Quality of Life in Patients with Primary Biliary Cirrhosis Using a Japanese Version of the PBC40 Questionnaire Satoru Kakizaki*, Shintarou Shiba, Ken Sato, Naondo Sohara, Daichi Takizawa, Tatsuya Ohyama, Takeshi Ichikawa, Kenichi Hosonuma, Masatoshi Yanagisawa, Hitoshi Takagi, Masatomo Mori

S1783

New Classification of Cytokeratin 20 (CK20) and Apomucin 1 (MUC1) Expression in Ampullary Carcinoma:Its Relationship with Tumor Progression and Prognosis Yasunari Kawabata*, Tsuneo Tanaka, Takashi Nishisaka, Touko Inao, Takeshi Nishi, Seiji Yano

S1784

Growth Rate of Gallbladder Polyp As Predictor to Neoplastic Polyp Su Rin Shin*, Jong Kyun Lee, Kyu Taek Lee, Kee Taek Jang, Seong Hyun Kim, Jong Chul Rhee

S1785

Liver Elasticity in Patients with Pancreatobiliary Disease Yoko Yashima*, Ryota Masuzaki, Toshihiko Arizumi, Osamu Togawa, Saburo Matsubara, Yousuke Nakai, Ryosuke Tateishi, Kenji Hirano, Naoki Sasahira, Takeshi Tsujino, Hiroyuki Isayama, Minoru Tada, Haruhiko Yoshida, Takao Kawabe, Masao Omata

S1786

Endoscopic Papillary Large Balloon Dilatation After Endoscopic Sphincterotomy for Bile Duct Stones in Difficult Sphincterotomy Young Hwangbo, Seok Ho Dong*, Jae Young Jang, Hyo Jong Kim, Byung-Ho Kim, Young Woon Chang, Rin Chang

S1787

Benefits of Temporal Endoscopic Gallbladder Stenting (EGS) Followed Laparoscopic Transcystic Removal in Cholecystitis Maki Sugimoto*, Hideki Yasuda, Keiji Koda, Masato Suzuki, Masato Yamazaki, Tohru Tezuka, Chihiro Kosugi, Ryota Higuchi, Yohsuke Yagawa

S1788



Outcome of Biliary Dyskinesia in Pediatrics and a New Definition of Gallbladder Ejection Fraction for Diagnosis Yamen Smadi, Anur Praveen, Abdelkader Hawasli, Hernando Lyons*

S1789



Decreased Expression of Intestinal Chemokine TECK/ CCL25 in Experimental Obstructive Jaundice and Its Reversal By Internal Biliary Drainage Tsunenori Fujita*, Taku Matsumoto, Tetsuo Ajiki, Kenro Hirata, Haruki Morimoto, Yonson Ku

S1790

Development of a Bioabsorbable Stent to Treat Benign Biliary Stenosis Mitsuo Miyazawa, Masayasu Aikawa, Katsuya Okada, Yoshihide Otani, Isamu Koyama, Yoshito Ikada, Yasuko Toshimitsu*

S1791

Vitamin K, Vitamin D and PTH Status in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP) Leon Fisher*, Alexander A. Fisher

Denotes DDW Poster of Distinction

P-173

S U N D A Y MAY 18

POSTER SESSIONS—BASIC AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Liver & Biliary

Sponsored by: Liver & Biliary

HEPATIC BILE FORMATION AND GALLSTONE PATHOGENESIS

LIVER TRANSPLANTATION

Participants will be able to: • Evaluate new information for the practicing gastroenterologist in developments related to liver transplantation; • Learn about the mechanisms of hepatic bile formation; and • Learn about the mechanisms of gallstone pathogenesis. S1792

MAY 18

Hepatolithiasis in Japan: Epidemiology Update and a Cohort Study in 473 Patients Toshiyuki Mori*, Yutaka Suzuki, Masanori Sugiyama, Yutaka Atomi

S1793

Analysis of Oxysterols in the Rabbit Gallbladder in the Experimental Cholecystitis Seok Ho Dong*, Christopher E. Savard, Rahul P. Kuver, Sum P. Lee

S1794

Sickle Hemoglobinopathy-Associated Cholelithiasis and Biliary Obstruction: A Single Center Experience Charles S. Landis*, Brian S. Levitt, Lawrence J. Brandt

S1795

S U N D A Y

AGA Institute Poster Session 8:00 AM - 5:00 PM

S1796

S1797

S1798

S1799

S1800



P-174

Decreased Spontaneous Activity and Excitability of Gallbladder Smooth Muscle in a Mouse Model of Gallstone Disease Onesmo B. Balemba*, Brigitte Lavoie, Aaron C. Bartoo, Gary M. Mawe A Model to Explain the Resistence to Fracture of Some Gallstones and the Longevity of Unstable Polymorphs of Calcium Carbonate in Gallstones Based On SEM and Infrared (IR) Spectral Data R. D. Soloway*, D. R. Taylor, M. D. Stringer, J. Wen, J. G. Wu Risk Factors for Bile Duct Stone Recurrence After Endoscopic Biliary Sphincterotomy Jung Mi Kim*, Ho Soon Choi, Dong Hee Koh, Won Moon, Seung Chul Cho, Jai Hoon Yoon, Hang Lak Lee, Oh Young Lee, Byung Chul Yoon, Joon Soo Hahm, Min Ho Lee, Dong Hoo Lee Reversibility of Choledocal Dilation After Sphincterotomy and Stone Extraction in Patients with Choledocholithiasis Rasoul Sotoudehmanesh*, Morteza Khatibian, Ali Ali-Asgari, Shadi Kolahdoozan, Shadi Shahraeeni, Fatemeh Zeinali, Javad Mikaeli, Reza Ansari, Hossein Asle-Soleimani

Sails Pavilion San Diego Convention Center

Participants will be able to: • New information for the practicing gastroenterologist in developments related to liver transplantation. S1801



A Multi-Centered Prospective Analysis of Long-Term Causes of Mortality Post Liver Transplantation: Results of the Niddk Database Kymberly D. Watt*, Rachel A. Pedersen, Russell H. Wiesner, Michael R. Charlton

S1802

Relevance of Matrix Metalloproteinase (MMP)-2 and MMP-9 Gene Promoter Polymorphisms in Ischemia/ Reperfusion Injury and Rejection After Orthotopic Liver Transplantation Rogier W. Ten Hove, Bart Van Hoek, Johan Kuyvenhoven, Bert Jan F. de Rooij, Daniel W. Hommes, Cornelis B. Lamers, Hein W. Verspaget*

S1803

In Vitro Hepatocyte Differentiation of Mesenchymal Stem Cells Derived from Human Bone Marrow Won Moon*, Ho Soon Choi, Shin Hee Kim, Young Yiul Y. Lee, Won Kyu Kim, Joon Soo Hahm, Jin Sun Yoon, Oh Young Lee, Byung Chul Yoon, Hang Lak Lee

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility

BRAIN-GUT INTERACTIONS AND NEUROIMAGING Participants will be able to: • Better understand the role of the brain in the modulation of GI function. S1804

Altered Kynurenine Pathway Metabolism in Irritable Bowel Syndrome (IBS)-Evidence of Indoleamine 2,3Dioxygenase (IDO) Activation in a Male Cohort Gerard Clarke*, Peter Fitzgerald, John F. Cryan, Eamonn M. Quigley, Timothy G. Dinan

S1805

Dietary Lectins As the Environmental “Unknown Pathogen” in Parkinson's Disease Jolene Zheng

S1806

Potential Roles of Sphingolipid Metabolites in Murine Gallstone Formation Via MAPK and AKT Pathways Beom Jae Lee*, Jae Seon Kim, Sehe Dong Lee, Ji Hoon Kim, Jong Eun Yeon, Jong-Jae Park, Kwan Soo Byun, Young-Tae Bak, Hwan-Soo Yoo, Seikwan Oh

Central Neuronal Mechanisms of GES and Effects of Stimulation Parameters and Locations in Regular and Diet-Induced Obese Rats Jing Zhang*, Hongbing Zhu, Jiande Chen

S1807

A Reference Database for Gallbladder Motility Assessed By Ultrasonography in Health and Disease Piero Portincasa*, Massimo Berardino, Francesca Bello, Luigi Borraccino, David Q. Wang, Oana N. Marin, Antonio Moschetta, Giuseppe Palasciano

Cognitive Coping Mechanism of Limbic/Paralimbic System in the Modulation of Placebo Analgesia in Visceral Pain: A 3t-fMRI Study Hsueh-Chieh Lu, Ching-Liang Lu*, David M. Niddam, JenChuen Hsieh, Full-Young Chang, Shou-Dong Lee

S1808

Exploring the Neural Processing of Visceral Sensations: The Influence of Sensory, Emotional and Cognitive Factors Steven J. Coen*, Qasim Aziz, Lidia Yágüez, Mick Brammer, Steven C. Williams, Lloyd J. Gregory

S1809

Repeated Esophageal Distension Shortens the Stimulus Response Latency of fMRI Activation Signals Mark Kern*, Adeyemi Lawal, Reza Shaker

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC S1810

Evaluation of Spino-Anorectal Pathways in Spinal Cord Injury with Bowel Dysfunction Using Magnetic Stimulation: A Novel and Noninvasive Test Kasaya Tantiphlachiva, Jose M. Remes-Troche, Ashok Attaluri, Jessica A. Paulson, Thoru Yamada, Satish S. Rao*

S1811

The Neurophysiology of Gastric Sensation in Functional Dyspepsia: Role of Abuse History and Somatization Lukas Van Oudenhove*, Joris U. Vandenberghe, Patrick Dupont, Brecht Geeraerts, Guy Bormans, Dominique Vanderghinste, Koen Van Laere, Stijn Dirix, Rita Vos, Koen Demyttenaere, Jan F. Tack

S1812

S1813

S1814

S1815

S1816

S1817

The Neurophysiology of Gastric Sensation in Functional Dyspepsia: Does Gastric Sensitivity Matter? Lukas Van Oudenhove*, Joris U. Vandenberghe, Patrick Dupont, Brecht Geeraerts, Guy Bormans, Dominique Vanderghinste, Koen Van Laere, Stijn Dirix, Rita Vos, Koen Demyttenaere, Jan F. Tack Disruption of Human Swallowing Behaviour to a ‘Virtual Lesion' of Swallowing Motor Cortex Is Reversed By Pharyngeal Electrical Stimulation Vanoo Jayasekeran*, Samantha Jefferson, Amandip S. Sandhar, Satish Mistry, John C. Rothwell, Shaheen Hamdy Aberrant Connectivity of Brain Centers During Somatic Pain and Activation of Endogenous Pain Modulation in IBS Compared to Healthy Controls Steven Graham, Clive H. Wilder-Smith*, Guanghui Song, Khay Guan Yeoh, Khek Yu Ho Defining the Sensory-Motor Disconnect in Basal and Adaptive Esophageal Reflexes in Human Neonates with Laryngoscopic Abnormalities Sudarshan R. Jadcherla*, Alankar Gupta, Walter Kim, Soledad A. Fernandez, Reza Shaker, Gregory J. Wiet Effects of NK-1 Receptor Antagonist AV608 On Emotional Circuitry and Affect in Female IBS Patients Joshua A. Bueller*, Kirsten Tillisch, Bruce D. Naliboff, Brandall Y. Suyenobu, Suzanne R. Smith, Roger E. Bolus, Emeran A. Mayer Visceral Hyperalgesia Is Associated with Somatic Hyperalgesia and Deficits in Pain Modulation in Patients with Irritable Bowel Syndrome (IBS) Piché Mathieu*, Marianne Arsenault, Pierre Poitras, Pierre Rainville, Mickael Bouin

S1818

Psychological Co-Morbidity with Irritable Bowel Syndrome Is Influenced By Heredity: A U.S. Co-Twin Study Nicholas J. Talley*, Mike Jones, Anthony Lembo

S1819

Effects of Short Pulse Gastric Electric Stimulation On Nerves Containing 5-Hydroxytryptamine or Dynorphin in Nucleus of Solitary Tract of Rat Tingting Zhan, Xian Qiao, Jinsong Liu*

S1824

Selective Peripheral Activation of CorticotropinReleasing Factor (CRF) Receptor Type 1 (CRF1) By Cortagine: A New Model of IBS-D-Like Symptoms in Rodents Muriel H. Larauche*, Pu-Qing Yuan, Guillaume Gourcerol, Lixin Wang, Karina Pambukchian, Stefan Brunnhuber, David W. Adelson, Mulugeta Million, Jean E. Rivier, Yvette Tache

S1825

The Role of the Central Amygdaloid Nucleus in the Regulation of Colonic Motility Kalina M. Venkova*, Kristen M. Campbell-Dittmeyer, Beverley Greenwood-Van Meerveld

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility

FECAL INCONTINENCE, PELVIC FLOOR DISORDERS, AND OTHER ANORECTAL DISORDERS Participants will be able to: • Evaluate new research in fecal incontinence, pelvic floor disorders and other anorectal disorders. S1826



Translumbar and Transsacral Magnetic Stimulation–a Novel Test of Assessing Anorectal Neuropathy in Fecal Incontinence Satish S. Rao*, Kasaya Tantiphlachiva, Ashok Attaluri, Jessica A. Paulson, Jose M. Remes-Troche, Thoru Yamada

S1827

External Anal Sphincter Plication: A Novel Surgical Approach to Enhance the Anal Canal Function Mahadevan R. Rajasekaran*, Yanfen Jiang, Amir Motamedi, Ravinder K. Mittal

S1828

Fecal Incontinence in Patients with Irritable Bowel Syndrome Pernilla Jerlstad*, Per Jerndal, Martin Karpefors, Alfred Bayati, Gisela Ringstrom, Pia Agerforz, Hasse Abrahamsson, Magnus Simren

S1829



Twelve Month Follow-Up for Patients with Fecal Incontinence Reporting Adequate Relief After a 4-Week Education and Medical Management Run-in Intervention Steve Heymen*, Yolanda V. Scarlett, William E. Whitehead

S1830

Twelve Month Follow-Up for Patients with Pelvic Floor Dyssynergia-Type Constipation (PFD) Reporting Adequate Relief After a 4-Week Education and Medical Management Run-in Intervention Steve Heymen*, Yolanda V. Scarlett, William E. Whitehead

S1831

Health Care Costs Associated with Fecal Incontinence Steve Heymen*, Olafur S. Palsson, Michael Von Korff, Rona L. Levy, Marsha J. Turner, William E. Whitehead

S1820

Somatic Afferent Modulation of Thoracic (T9-T10) Spinal Neurons Receiving Gastric Mechanical Input in Rats Chao Qin*, Jiande Chen, Jing Zhang, Robert D. Foreman

S1832

National Health and Nutrition Examination Survey (NHANES): Association of Usual Stool Consistency and Frequency with Fecal Incontinence William E. Whitehead

S1821

Central Mechanisms of Esophageal Hypersensitivity in Patients with NERD and Functional Heartburn Yanli Zhang*, Hui You, Meiyun Ke, Feng Feng, Xiucai Fang

S1833

S1822

Intracolonic Lidocaine Reverses Visceral and Somatic Hypersenstitivity Post-TNBS Colitis QiQi Zhou*, Donald Price, G Nicholas Verne

National Health and Nutrition Examination Survey (NHANES) of Fecal Incontinence: Characteristics of Incontinent Stools William E. Whitehead

S1834

Electrical Stimulation Therapy in Chronic Functional Constipation: 5 Years Experience in Patients Refractory to Biofeedback Therapy and with Rectal Hyposensitivity Kee Wook Jung*, Seung-Jae Myung, Jeong-Sik Byeon, In ja Yoon, Jeung Eun Ko, Soon Man Yoon, Mi Young Do, Do Hoon Kim, Benjamin Kim, Seunghyun Kwon, Byong Duk Ye, Hwoon-Yong Jung, Suk-Kyun Yang, Jin-Ho Kim

S1823

Do Mast Cells Contribute to Visceral Hypersensitivity in Adult Rats Following Neonatal Psychological Stress? Niall P. Hyland*, Siobhain M. O'Mahony, David C. Bulmer, Kevin Lee, Timothy G. Dinan, John F. Cryan

Denotes DDW Poster of Distinction

P-175

S U N D A Y MAY 18

POSTER SESSIONS—BASIC S1835

Effect of Biofeedback Therapy and the Factors Affecting Responsiveness in Patients with Rectal Hyposensitivity Kee Wook Jung*, Seung-Jae Myung, Jeong-Sik Byeon, In ja Yoon, Jung eun Ko, So young Seo, Soon Man Yoon, Mi Young Do, Do Hoon Kim, Benjamin Kim, Seunghyun Kwon, Byong Duk Ye, Hwoon-Yong Jung, Suk-Kyun Yang, Jin-Ho Kim

S1836

Functional Anorectal Disorders Are More Prevalent in Women with a History of Sexual Abuse Jose M. Remes-Troche*, Antonio Ramos-De la Medina, Max J. Schmulson, Silvia Cid-Juarez, Federico B. Roesch

S1837

S1838

S1839

S U N D A Y MAY 18

S1840

Health Care Costs and Utilization in Patients with Chronic Constipation Thao V. Nguyen*, Olafur S. Palsson, Michael Von Korff, Andrew D. Feld, Rona L. Levy, Marsha J. Turner, William E. Whitehead Characterization of Pressure Patterns in Distal Colonic and Rectal Motility Activity Between Healthy Volunteers and Patients with Dyssynergic Defecation Using An Ambulatory Capsule, Smartpill Lenuta Kloetzer*, Alexandru Gaman, Richard McCallum, Kenneth L. Koch, Michael D. Sitrin, William D. Chey, Jeffrey M. Lackner, Leonard A. Katz, Gregory E. Wilding, Henry P. Parkman, Irene Sarosiek, Carrie Miller, Richard J. Saad, Satish S. Rao, Jack Semler, William L. Hasler, Braden Kuo Levator Ani or Pelvic Floor Muscles: What Is in the Name? Varuna Raizada*, Sung-Ae Jung, Robert F. Mattrey, Milena M. Weinstein, Dolores H. Pretorius, Charles W. Nager, Ravinder K. Mittal The Bowel Guarding Response As a Measure of External Anal Sphincter Function in Idiopathic Fecal Incontinence Adeel A. Bajwa*, Kumaran Thiruppathy, Prateesh Trivedi, Anton V. Emmanuel

S1841

Evidence of External Anal Sphincter Atrophy and Disturbed Autonomic Activity in Systemic Sclerosis Nora M. Thoua*, Adeel A. Bajwa, Stuart A. Taylor, Anton V. Emmanuel

S1842

Optimal Frequency of Sacral Nerve Electrical Stimulation to Promote Bowel Emptying in Spinal Cord Injured Rats Yong Sung Kim*, Moon Young Lee, Suck Chei Choi, Min Chul Joo, Byoung Kwan Son, Yong Leol Oh, Jung Taek Oh, Sang Wook Kim

S1843

Double-Blind, Placebo-Controlled, Randomised Assessment of Repeat Dosing to the Anal Canal Using L-Erythro-Methoxamine Gel, a Local Alpha-Agonist for Sphincter Tone Improvement Hans-Jurgen Gruss

S1844

Virtual Reality Based Biofeedback Is An Effective Treatment for Pelvic Floor Disorders Narasimha S. Reddy*, Lakshmi Prasad N. Rao, Asha Misra, Uday C. Ghoshal

S1845

National Health and Nutrition Examination Survey (NHANES) of Fecal Incontinence: Prevalence By Sex, Age, Race, Marital Status, Education, and Income William E. Whitehead

S1846

Normal Values for High Resolution Anorectal Manometry (HRARM) Michael P. Jones*, Jason Bratten, Sudip K. Ghosh, Jennifer M. Post, Michael D. Crowell

P-176

S1847

Randomized Controlled Trial of Biofeedback, Electrical Stimulation, and Biofeedback Plus Electrical Stimulation in Patients with Severe Fecal Incontinence After ColoAnal Anastomosis Maria Pia Caldarella*, Mariaelena Serio, Angelo Milano, Chrysanthi Balatsinou, Francesco Laterza, Matteo Neri

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility

FOOD INTAKE, OBESITY AND BRAIN GUT INTERACTIONS Participants will be able to: • Learn more about regulation of food intake, obesity and brain-gut interactions. S1848

A Meal Provocation Test for Patients with Irritable Bowel Syndrome Reflects Disease Severity Stine Storsrud*, Irina Midenfjord, Iris Posserud, Hans Strid, Anette Lindh, Jenny Wallin, Pernilla Jerlstad, Pia Agerforz, Gisela Ringstrom, Hasse Abrahamsson, Magnus Simren

S1849

Appendix Electrical Stimulation: A Potential Therapeutic Strategy for Obesity Yong Lei*, Jiande Chen

S1850

Gastric Electrical Stimulation Induced Gastric Distention in Obese Rats Yong Lei*, Jiande Chen

S1851

Duodenum Electrical Stimulation Energy Dependently Inhibited the Liquid Gastric Emptying in Pigs Xiaohong Xu*, Yong Lei, Jiande Chen

S1852

IBS Patients Have a Poorer Quality Diet and Exercise Less Than Organic GI Disease Patients or Normal Controls E. Jan Irvine*, Jenny Kim, Gesine L. Alders, Emily Ching

S1853

Eating Behavior Modulates Ghrelin Surge, Resulting in Potent Interdigestive Gastric Contractions and Acceleration of Gastric Emptying in Rats Hajime Ariga*, Kenji Imai, Cindy Chen, Christopher R. Mantyh, Theodore N. Pappas, Toku Takahashi

S1854

Overweight in Irritable Bowel Syndrome Is Associated with More Severe Symptoms of Diarrhea Jan Brun*, Per Jerndal, Martin Karpefors, Alfred Bayati, Gisela Ringstrom, Pia Agerforz, Riadh Sadik, Hasse Abrahamsson, Magnus Simren

S1855

Inhibitory Effects of Electrical Stimulation of Various Organs Along the Gut On Antral Motility in Dogs Xiaohong Xu*, Jiande Chen

S1856

Hunger Scores Correlate with the Occurrence of Pharmacologically Induced Gastric Phase 3 in Man Daphne C. Ang*, Heleen Nicolai, Rita Vos, Pieter Vanden Berghe, Daniel Sifrim, Inge Depoortere, Theo L. Peeters, Jozef Janssens, Jan F. Tack

S1857

Peripheral Obestatin Has No Effect On Fos Induction in Hypothalamic and Brainstem Nuclei Which Are Involved in Feeding Behavior Miriam Goebel*, Anna-Sophia Wisser, Peter Kobelt, Andreas Stengel, Ivo R. van der Voort, Bertram Wiedenmann, Burghard F. Klapp, Yvette Tache, Hubert Monnikes

S1858

Long-Term High Lipids or High Carbohydrates Diets Alter Antro-Duodenal Motor Patterns Irrespective of Their Caloric Contents Dominique Bligny*, Sylvie Guérin, Alain Chauvin, Benoit Janson, Charles-Henri Malbert

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC AGA Institute Poster Session 8:00 AM - 5:00 PM

S1887

Dispersed Pancreatic Acini Have Strong CFTR Protein Expression and Exhibit An Anti-Apoptotic Phenotype in a Non-Acidic Extracellular Milieu Kwang-Deok Moon, Stephen A. Ernst, Sae-Hong Lee, Chung Owyang, Matthew J. DiMagno*

S1888

The Pancreatitis-Induced Membrane Protein VMP1 That Triggers Autophagy Interacts with S100A10 Romina P. Pardo, Andrea E. Lo Ré, Daniel Grasso, Alejandro Ropolo, Veronica Boggio, Juan L. Iovanna, Maria I. Vaccaro*

S1889

PKCθ Is Expressed in Pancreatic Acini and Rapidly Activated By CCK and Other Calcium-Mobilizing Agents Veronica Sancho*, Marc J. Berna, Michelle Thill, Nieves Gonzalez, Samuel A. Mantey, Tapas K. Pradhan, Robert T. Jensen

S1890

A Novel Interaction of Ezrin with Cortactin in Podosomal Rosette Assembly in Pancreatic Cancer Cells Hemant Kocher*, Jennifer Sandle, Tariq A. Mirza, Ningfeng Fiona Li, Ian R. Hart

S1891

RhoC Enhances Pancreatic Carcinoma Cell Migration By Mediating Integrin Signaling and Podosome Formation Ningfeng Fiona Li, Fieke E. Froeling, Ian R. Hart, Hemant Kocher*

S1892

Expression Profile of Genes Coding for DNA Repair in Human Pancreatic Cancer Dan Ionut Gheonea*, Mihai Ioana, Adrian Saftoiu, Tudorel Ciurea

Sails Pavilion San Diego Convention Center

Sponsored by: Nutrition & Obesity

NUTRITION AND CANCER Participants will be able to: • Review recent research on nutrition and its relationship to the pathogenesis and treatment of cancer. S1869

S1870

S1871

S1872

S1873

TGFβ-Dependent Polyamine Depletion Is Associated with Cell Growth Inhibitory Effects of Isothiocyanate Sulforaphane in Colon Cancer Cells Bettina M. Ecker*, Christoph Jochem, Waranya Kampan, Stefan Loitsch, Jürgen Stein, Sandra Ulrich Nutrient Intake and Microsatellite Instability in Sporadic Colon Cancers Sung-Wook Oh*, Young-Ho Kim, Dong Kyung Chang, Hee Jung Son, Poong-lyul Rhee, Jae J Kim, Jong Chul Rhee, Woo-Yong Lee, Ho Kyung Chun, Duk-Hwan Kim P53-Dependent and p53-Independent Mechanisms of Apoptosis in Human Colorectal Cancer Cell Lines Following Treatment with Honokiol William L. Berry*, Courtney W. Houchen, Shrikant Anant A Novel In Vitro Detection Method to Identify Dietary Chemopreventive Agents Utilizing the NF-κB Pathway Dharmalingam Subramaniam*, Satish Ramalingam, Gary D. Stoner, Sripathi M. Sureban, Courtney W. Houchen, Rama P. Ramanujam, Shrikant Anant

S U N D A Y

Metabolic Syndrome Is a Risk Factor for Colorectal Adenoma Takafumi Sugimoto*, Yutaka Yamaji, Haruka Kajiwara, Noriyuki Takano, Atsuo Yamada, Miki Ohta, Masao Akanuma, Goichi Togo, Keiji Ogura, Takao Kawabe, Masao Omata

AGA Institute Poster Session 8:00 AM - 5:00 PM

MAY 18

Sails Pavilion San Diego Convention Center

Sponsored by: Pancreatic Disorders

PANCREATIC PHYSIOLOGY AND PATHOBIOLOGY I Participants will be able to: • Understand the physiology of pancreatic function. S1883

Muclin (Dmbt1) Deficiency Slows Traffic of Regulated Secretory Protein in the Pancreatic Acinar Cell Robert C. De Lisle*, Donna Ziemer

S1884

TGFβ Activates PKCα Through the Store-Operated CA2+ Channel (SOC) in Pancreatic Cancer Cells Jimmy Chow*, Hui Dong, Makiko Ban, John M. Carethers

S1885

TGFβ Utilizes NF-κB to Mediate PTEN Suppression in a Smad-Independent Manner in Pancreatic Cancer Cells Jimmy Chow*, Heekyung Chung, Stephanie S. Tam, John M. Carethers

S1886

Pancreatic Transdifferentiation Induced By Signal Transduction System of c-Kit Receptor Tyrosine Kinase and Its Ligand Stem Cell Factor Makoto Satake*, Tetsuhiro Hamada, Guido Eibl, Kazuhiro Suzumura, Tadamichi Hirano, Toshihiro Okada, Nobukazu Kuroda, Vay L. Go, Jiro Fujimoto, Tohru Tsujimura

Denotes DDW Poster of Distinction

P-177

POSTER SESSIONS—COMBINED COMBINED AASLD Poster Session 8:00 AM - 5:00 PM

S1903

Beneficial Effects of UDCA and Ncx-1000 Alone or in Combination with Vitamin E in a Nonalcoholic Steatohepatitis Rat Model Yara Haddad*, Diane Vallerand, Antoine Brault, Jean Spenard, Pierre S. Haddad

S1904



Gene Expression Associated with Hepatic Steatosis in Patients with Chronic Hepatitis C (Ch-C) Genotype 1 Zobair M. Younossi*, Ancha Baranova, Arian Afendy, Maria Stepanova, Noreen Hossain, Issah Younossi, Kathy Ankrah, Manirath k. Srishord, Chris Santini, Joanne Chan, ShengYung P. Chang

S1905



Lack of Correlation Between Diet Composition and Pediatric NAFLD Severity Miriam Vos*, Ryan Colvin, Patricia H. Belt, Daphne Bryan, Jean P. Molleston, Karen F. Murray, Philip Rosenthal, Jeffrey Schwimmer, James Tonascia, Aynur Unalp, Joel E. Lavine

S1906

Lifestyle Intervention and Antioxidants in Children with Nonalcoholic Fatty Liver Disease: A Randomized, Controlled Trial Valerio Nobili*, Melania Manco, Rita DeVito, Andrea PietroBattista, Donatella Comparcola, Maria R. Sartorelli, Fiorella Piemonte, Matilde Marcellini, Paul Angulo

Sails Pavilion San Diego Convention Center

ALCOHOLIC AND NONALCOHOLIC STEATOHEPATITIS S1893



Comparison of Plasma Insulin and Leptin Concentrations with Long Chain Fatty Acid Uptake in Hepatocytes and Adipocytes from Mice with Hepatic Steatosis Clarifies the Hormonal Regulation of Fatty Acid Disposition Shengli Zhou, Fengxia Ge, Paul D. Berk*

S1894

Physical Activity and Short-Term Inactivity Modulate Hepatic Fatty Acid Oxidation and Lipogenesis Proteins in Otsuka Long-Evans Tokushima Fatty (Oletf) Rats Scott Rector*, John P. Thyfault, Matthew J. Laye, Robert T. Morris, Sarah J. Borengasser, Grace M. Uptergrove, Frank W. Booth, Jamal A. Ibdah



S U N D A Y MAY 18

S1895

Effect of Angiotensin II Type 1 Receptor Antagonist On Insulin Resistance and Hepatic Steatosis in the FA/Fa Obese Rat Junitsu Ito*, Junji Yokozawa, Takafumi Saito, Kazuo Okumoto, Yuko Nishise, Hisayoshi Watanabe, Koji Saito, Hitoshi Togashi, Sumio Kawata

S1907

S1896

Curcumin Inhibits Ox-LDL-Activated Hepatic Stellate Cells In Vitro By Suppressing Gene Expression of Lectin-Like Oxidized-LDL Receptor Via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Qiaohua Kang*, Anping Chen, Jawahar L. Mehta

Association Between Ppargc1a Polymorphisms and the Occurrence of Nonalcoholic Fatty Liver Disease (NAFLD) Masato Yoneda*, Koji Fujita, Yuichi Nozaki, Hiroyuki Kirikoshi, Atsushi Nakajima

S1908

Mitochondrial Dysfunction Contributes to Angiotensin II-Induced Nonalcoholic Fatty Liver Disease in Transgenic Ren2 Rats Yongzhong Wei*, Suzanne E. Clark, James R. Sowers, Jamal A. Ibdah

Suspected Nonalcoholic Fatty Liver Disease and Mortality Risk in a Population-Based Cohort Study Winston Dunn*, Ronghui Xu, Deborah L. Wingard, Christopher Rogers, Paul Angulo, Zobair M. Younossi, Jeffrey Schwimmer

S1909

Clinical and Liver Histological Differences in Patients with Nonalcoholic Fatty Liver Disease (NAFLD) with and Without Diabetes Mellitus (DM) Ye-Jin Lee*, Donald M. Jensen, Helen S. Te, Nancy Reau, Kapuluru G. Reddy, Rohit S. Satoskar, Poonam Mishra, John Hart, Smruti R. Mohanty

S1910

Use of Statins in Patients with Hyperlipidemia and Abnormal Liver Enzymes. Survey of Prescribing Practice Among Primary Care Physicians Fadi S. Rzouq*, Rajasekhara R. Mummadi, Gagan Sood

S1911

Bariatric Surgery Ameliorates Non-Alcoholic Fatty Liver Disease By Switching the Adipocytokine Profile to a Protective State Alexander R. Moschen*, Clemens Molnar, Helmut Weiss, Sabine Geiger, Ivo W. Graziadei, Patrizia L. Moser, Herbert Tilg

S1912

Novel Diagnostic Approach for NASH Using [11c] Choline Dynamic PET Imaging Koji Fujita*, Yuichi Nozaki, Masato Yoneda, Hiroyuki Kirikoshi, Masahiko Inamori, kensuke kubota, Satoru Saito, Atsushi Nakajima

S1913

Visceral Fat As a Strong and Independent Risk Factor of Nonalcoholic Fatty Liver Disease Donghee Kim*, Bum Joon Park, Won Kim, Yong Jin Jung, Yoon Jun Kim, Jung-Hwan Yoon, Hyo-Suk Lee

S1897

S1898

Hepatic Steatosis Is Associated with Increased Intrahepatic NKT Cell Infiltration Michael E. Adler*, Sarah Taylor, Okebugwu Kamalu, Herman Yee, Christine Ren, George A. Fielding, Michael A. Poles

S1899

Genetic Ablation of Bach1 Followed By Upregulation of Heme Oxygenase-1 Improved Nonalcoholic Steatohepatitis in Rodent Model Motoki Inoue*, Susumu Tazuma, Kazuhiko Igarashi, Hideyuki Hyogo, Keishi Kanno, Michihiro Nonaka, Yoshitaka Nabeshima, Keiko Iwamoto, Tomokazu Ishitobi, Tamito Sasaki, Kazuaki Chayama

S1900

Mitochondrial Complex III Is Decreased in Morbidly Obese Patients with Nonalcoholic Steatohepatitis Kamran Qureshi*, Michelle S. Johnson, Ronald H. Clements, Gary A. Abrams, Aimee L. Landar

S1901

Ursodeoxychoric Acid Blocks Progression of NASH -An Examination Using Hepatocyte-Specific PTEN Deficient MiceShigetoshi Ohshima*, Yasuo Horie, Takashi Goto, Tomomi Shibuya, Ikuhiro Yamada, Masahiro Iizuka, Akira Suzuki, Hirohide Ohnishi

S1902

P-178

Oxidative Stress Facilitates Apoptosis of Hepatocyte Via TNF-Ask1 Pathway in Murine Non-Alcoholic Steatohepatitis Model Hiroshi Kudo*, Yutaka Yata, Terumi Takahara, Kengo Kawai, Toshiro Sugiyama

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED S1914

Fatty Liver Is Associated with Diabetes and Hyperlipidemia Components of the Metabolic Syndrome Independent of Other Fat Depots Including Visceral Fat in a Large Community Based Cohort: The Framingham Heart Study Elizabeth K. Speliotes*, Joseph M. Massaro, Udo Hoffmann, Ramachandran S. Vasan, Dushyant V. Sahani, Joel Hirschhorn, Christopher J. O'Donnell, Caroline S. Fox

S1915

Utility of Xenon-133 Liver Scan in the Diagnosis and Management of Non-Alcoholic Fatty Liver Disease (NAFLD) Said A. Al-Busafi*, Maged Peter Ghali, Philip Wong, Marc Deschenes

S1916

CT Values of Multifidus and Psoas Muscles in Umbilical CT Are Good Markers for Aging and Visceral Fat Accumulation in Fatty Liver Patients Aki Matsunobu*, Yoichiro Kitajima, Yuichiro Eguchi, Eriko Ishibashi, Toshihiko Mizuta, Iwata Ozaki, Ryuichi Iwakiri, Naofumi Ono, Takahisa Eguchi, Kazuma Fujimoto

S1917

Clinicopathological Features in Nonalcoholic Steatohepatitis Autopsy Cases Satoru Yatsuji*, Etsuko Hashimoto, Haruka Noto, Ayae Kabutake, Maki Tobari, Makiko Taniai, Katsutoshi Tokushige, Keiko Shiratori

S1918

Liver Disease Severity and Risk of Kidney Damage in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) Saurabh Agrawal*, Rocio Lopez, Jason T. Omo, Hari S. Conjeevaram

S1919

Family History and Familial Aggregation in Patients with Nonalcoholic Steatohepatitis Haruka Noto*, Katsutoshi Tokushige, Etsuko Hashimoto, Ayae Kabutake, Maki Tobari, Satoru Yatsuji, Makiko Taniai, Keiko Shiratori

S1920

Are Angiotensin-Receptor Blockers Candidates for FirstChoice Treatment in Non-Alcoholic Steatohepatitis (NASH) Associated to Mild-to Moderate Hypertension? Eugen F. Georgescu*, Reanina I. Ionescu, Marius Georgescu

S1921

Prevalence and Profile of Nonalcoholic Fatty Liver Disease in a Philippine Tertiary Hospital Therese C. Macatula

S1922

Predictive Factors for Severity of Liver Histology in Patients with Non-Alcoholic Steatohepatitis: Usefulness of Measurement of Arteriosclerosis Indicators Koichiro Furuta*, Shuichi Sato, Junichi Ishine, Eisuke Okamoto, Hiroshi Tobita, Tatsuya Miyake, Shunji Ishihara, Yuji Amano, Kyoichi Adachi, Riruke Maruyama, Yoshikazu Kinoshita

S1923

Fasting Insulin Is Predictive of Hepatic Fat Fraction in Latina Girls Rebecca N. Cherry*, Christian K. Roberts, Michael I. Goran

S1924

Relationship Between Adipokine Hormone Levels, Liver Fibrosis, and Inflammatory Activity in Lean and Overweight Asian Patients with Non-Alcoholic Fatty Liver Disease Wiriyaporn Ridtitid*, Sombat Treeprasertsuk, Bubpha Pornthisarn, Rungsunn Tungtrongchitr, Varocha Mahachai

S1925



S1926

Increased Short-Term Risk for Liver-Related Mortality Parallels Accumulation of Hedgehog-Responsive Progenitors in Patients with Alcoholic Steatohepatitis Youngmi Jung*, Kevin D. Brown, Rafal P. Witek, Alessia Omenetti, Liu Yang, Hendrika Vandongen, Richard J. Milton, Ian Hines, Richard A. Rippe, Laurent Spahr, Laura Rubbia-Brandt, Anna Mae Diehl

S1927

Misoprostol, a Potential Therapeutic Agent for Alcoholic Hepatitis, Modulates Cytokine Activity Through cAMP Pathway Leila Gobejishvili*, Rehan Khan, Swati Joshi-Barve, Shirish Barve, Craig J. McClain, Daniell B. Hill

S1928

Molecular and Histopathological Analyses of Experimental Rat Models of Low, Intermediate, or High Susceptibility to Alcohol-Induced Liver Injury Sarah M. DeNucci*, Suzanne M. de la Monte, Ming Tong, Jack R. Wands

AASLD Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

HCV PATHOGENESIS AND CLINICAL TRIALS S1929

Visceral Fat Accumulation and Insulin Resistance Are Risk Factors for Increase in ALT in Chronic Hepatitis C in Males But Not in Females Aki Matsunobu*, Yuichiro Eguchi, Eriko Ishibashi, Noriko Oza, Yoichiro Kitajima, Shinji Iwane, Takumi Akiyama, Keisuke Ario, Tutomu Yasutake, Ryuichi Iwakiri, Iwata Ozaki, Toshihiko Mizuta, Kazuma Fujimoto

S1930

Metabolic Factors and Inflammatory Changes Are Responsible for Increased GammaGlutamyltranspeptidase Level in Chronic Hepatitis C Federica Benini, Marie Graciella Pigozzi, Luisa Bercich, Alessandro Reggiani, Bruno M. Cesana, Stefania S. Bertolazzi, Alessandra Mora, Alessandro Pozzi, Francesco Lanzarotto, Chiara Ricci, Alberto Lanzini*

S1931

Influence of Interleukin-10 Gene Promoter Polymorphisms On Disease Progression in Patients Infected with Hepatitis B Virus Jalil Tavakkol Afshari, hamid Reza Sima, Reza Mirzaei, Narges Valizadeh*, Ahmad. Ebadian, Abulfazl Mahmood Zadeh, Mohammad Khaedalouei, Houshang Rafatpanah, Ali Mokhtarifar

S1932

Effect of Nicotine On Innate Antiviral Pathways and HCV Replication Shunhei Yamashina*, Tomokazu Mizui, Kazuyoshi Kon, Kenichi Ikejima, Tsuneo Kitamura, Yoshiyuki Takei, Sumio Watanabe

S1933

The Difference of Hepatitis C Viral (HCV) Internal Ribosomal Entry Site (Ires) and Picornaviral IresMediated Translation Inhibited By Oligonucleotides Xiaoyu Li*, Steffen Mueller, Eckard Wimmer

S1934

Detection of Sen Virus in Chronic HCV Genotype 4 Infected Patients By PCR and Sequencing in Egypt Ahmed A. Monis*, Samia Girgis

S1935

Genotype Characterization and Phylogenetic Analysis of Hepatitis B Virus in North-East Iranian Population Houshang Rafatpanah, hamid Reza Sima*, Narges Valizadeh, Abulfazl Mahmood Zadeh, Narges Saed, Abbas Esmaeil Zadeh

S1936

Health-Related Quality of Life (HRQOL) with Albinterferon Alfa-2b Plus Ribavirin in IFN TreatmentNaïve Patients with Genotype 1 Chronic Hepatitis C Stephen Pianko*, Eric M. Yoshida, Stefan Zeuzem, Yves Benhamou, Vincent G. Bain, Erik Pulkstenis, John G. McHutchison, Mani Subramanian

Mitochondria DNA Damage and Repair in Alcohol Induced Liver Injury: Role of IL-6 Xiuying Zhang*, Shingo Tachibana, Bin Gao, George M. Williams, Zhaoli Sun



Denotes DDW Poster of Distinction

P-179

S U N D A Y MAY 18

POSTER SESSIONS—COMBINED S1937

Type of Response to Prior Pegylated Interferon Alfa-2b (12KD)/RBV Predicts Subsequent Response to Retreatment with Peginterferon Alfa-2a (40KD)/RBV Patrick Marcellin*, Bradley L. Freilich, Pietro Andreone, Adrian M. Di Bisceglie, Carlos E. Brandao-Mello, K. Rajender Reddy, Antonio Craxi, Antonio Olveira, Gerlinde Teuber, Diethelm Messinger, Greg Hooper, Matei Popescu, Donald M. Jensen

S1946

Antiviral Therapy Reduces Hepatic Venous Pressure Gradient (Hvpg) in HBV Cirrhotics with Portal Hypertension Christos Triantos, Spilios Manolakopoulos*, John Theodoropoulos, Jiannis Vlachogiannakos, George Papatheodoridis, Dimitrios Tzourmakliotis, Dimitrios G. Karamanolis, Andrew K. Burroughs, Athanasios Archimandritis

S1938

HCV-RNA Status At Week 12 of Treatment with Peginterferon Alfa-2a/RBV Predicts SVR in Patients with Prior Non-Response to Pegylated Interferon Alfa-2b/RBV: Results from Repeat Study Patrick Marcellin*, Bradley L. Freilich, Pietro Andreone, Adrian M. Di Bisceglie, Carlos E. Brandao-Mello, K. Rajender Reddy, Antonio Craxi, Antonio Olveira, Gerlinde Teuber, Diethelm Messinger, Greg Hooper, Matei Popescu, Donald M. Jensen

S1947

MELD, Child Score, and Fibrosis Indices in Predicting Outcome of Acute Variceal Bleeding G. a. Badra, Hassan E. Zaghla, Eman Abdel sameea, Nabil Omar, Ashraf AbuGabal, Saleh Mahmoud Saleh, Imam Waked*

S1949

Etiology of Anemia and Prevalence of Portal Hypertensive Gastropathy in Alcohol-Related Cirrhosis Gautam Mehta*, Mathena Pavan, Samer Taslaq, Kinesh P. Patel, Devinder S. Bansi, Andrew V. Thillainayagam

S1950

Bleeding Stomal Varices: Case Series and Systematic Review of the Literature Bret J. Spier*, Michael R. Lucey, Eric A. Johnson, Myron Wojtowycz, Layton F. Rikkers, Bruce A. Harms, Mark Reichelderfer

S1951

Higher Hospital Volume Predicts Endoscopy But Not inHospital Mortality in Patients with Acute Variceal Hemorrhage Ashwin N. Ananthakrishnan*, Emily L. McGinley, Kia Saeian

S1952

Mortality and Survival Predictive Models for Patients Admitted to a Gastroenterology Intensive Care Unit Due to Acute Variceal Bleeding Helena T. Sousa*, José M. Romãozinho, Bárbara Oliveiros, Manuela Ferreira, Pedro Amaro, Rita Figueirinha, Maximino C. Leitão

S1953

Esophageal Varices Recur Less Frequently in Elderly Than in Younger Patients Yoshihiro Furuichi*, Shigeki Ichimura, Ryou Metoki, Jyunichi Taira, Katsutoshi Sugimoto, Masahiko Yamada, Yasuharu Imai, Ikuo Nakamura, Fuminori Moriyasu

S1954

Autonomic Nervous System Dysfunction in Cirrhosis Heart Rate Variability. Does It Act As a Predictor of Variceal Bleed? Joye Varghese, Arun Kumar Muthusamy*, Murali Krishnan K, Jayanthi Venkatraman

S1955

Safety & Eradication Rate of Primary Prophylactic Esophageal Variceal Band Ligation Wasim Jafri, Mohammad Salih, Amna Subhan*, Nida Jafri, Saeed S. Hamid, Hasnain Shah, Shahab Abid, Rozina N. Wasaya

S1956

The Frequency of Endoscopic Diagnosis Other Than Esophageal Varices in Patients with Portal Hypertension and Esophageal Varices Luis F. Lara*, Shou Jiang Tang, Jayaprakash Sreenarasimhaiah, Samir Gupta, Marlyn J. Mayo, Peter F. Malet, William M. Lee, Don C. Rockey

S1957

The Changes in Clinical Outcomes of Variceal Bleeding in Cirrhotic Patients ; a 10-Year Experience in Gangwon Province, South Korea Young Don Kim*, Ki Tae Suk, Chang Soon Choi, Koon Hee Han, Woo Jin Jeong, Hye Young Choi, Moon Young Kim, Hye Jeong Kim, Jae Woo Kim, Sung Jung Kim, Gwang Ho Baik, Jin Bong Kim, Gab Jin Cheon, Soon Koo Baik, Dong Joon Kim

S1958

Validity Scores of Different Reagent Strips and Automated Cell Count for the Diagnosis of SBP Danai Limmathurotsakul, Narudee Bhokaisawan, Panarat Thaimai, Rungsun Rerknimitr*, Sombat Treeprasertsuk, Varocha Mahachai, Pinit Kullavanijaya

S1939

Viral Kinetics and Pharmacodynamics of Albinterferon Alfa-2b in Interferon Treatment-Naïve Patients with Genotype 1, Chronic Hepatitis C Avidan U. Neumann*, Lynn Rozenberg, Vincent G. Bain, John G. McHutchison, Erik Pulkstenis, Mani Subramanian

S1940

Biochemical Markers for Diagnosis of Fibrosis and Predicting SVR in HCV Genotype 2/3 Treated for 12 or 24 Weeks Martti Färkkilä*, Martin Lagging, Johan Westin, Nina Langeland, Court Pedersen, Mads Rauning Buhl, Kristine Morch, Gunnar P. Norkrans

S1941

Easy to Assess On-Treatment Parameters Correlate with Degree of Virological Response After 12 Weeks of Treatment Donald M. Jensen*, Bradley L. Freilich, Pietro Andreone, Adrian M. Di Bisceglie, Carlos E. Brandao-Mello, K. Rajender Reddy, Antonio Craxi, Antonio Olveira, Gerlinde Teuber, Diethelm Messinger, Greg Hooper, Matei Popescu, Andreas Tietz, Patrick Marcellin

S U N D A Y MAY 18

S1942

S1943

S1944

A Randomized Trial of Standard vs. Dose-Escalation Dosing of Ribavirin in Combination Therapy for Chronic Hepatitis C Patients with Genotype 1 and High Viral Load Yoshiaki Iwasaki*, Yasuyuki Araki, Ryo-ichi Okamoto, Hideaki Taniguchi, Yasuhiro Makino, Tohru Ohnishi, Hiroyuki Shimomura, Minoru Tomita, Kazuhisa Yabushita, Yasushi Ishii, Masaharu Ando, Kuniaki Hashimoto, Hiroshi Ikeda, Kouichi Takaguchi, Akinobu Takaki, Haruhiko Kobashi, Kohsaku Sakaguchi, Yasushi Shiratori, Kazuhide Yamamoto Stevioside As a Possible Antiviral Agent for Hepatitis C Virus Infection Kazuhisa Yuasa*, Ken Sato, Atsushi Naganuma, Hitoshi Takagi, Takeshi Ichikawa, Satoru Kakizaki, Masanori Ikeda, Nobuyuki Kato, Masatomo Mori Symptomatic and Physiologic Presentations in a Cohort of Pediatric Patients with Hepatitis C Wendy A. Henderson*, Colleen M. Hadigan, Jordan J. Feld, Seema Khan

AASLD Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

PORTAL HYPERTENSION S1945

P-180

Adherence and Adequacy of Therapy in Esophageal Varices Prophylaxis Haripriya Maddur*, Suraj Naik, Ali Siddiqui, Don C. Rockey

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED S1959

S1960

51cr-EDTA Permeability Test in Ascitic Cirrhotic Patients with and Without History of Spontaneous Bacterial Peritonitis Giuseppe Merra, Emidio Scarpellini*, Antonio Dal Lago, Lorenzo Zileri Dal Verme, Maria Grazia Spitilli, Cristiano Lauritano, Carlo Petruzzellis, Rosalba Finizio, Michele Santoro, Matteo Garcovich, Andrea Lupascu, Giovanni Gasbarrini, Giovanni Ghirlanda, Venanzio Valenza, Antonio Gasbarrini Development Phase of a New Point of Care Screening Test for Spontaneous Bacterial Peritonitis (SBP) Using the Leukocyte Esterase Method: Preliminary Results Michel H. Mendler, Erika Madrigal, Matthew M. Tsushima*, Elliot Joo, Arun K. Agarwal, Bruce A. Runyon

S1961

Critical Ischaemia in Peripheral Limbs During Terlipressin Treatment Aleksander Krag*, Flemming Bendtsen, Jens H. Henriksen, Søren Møller

S1962

Effects of Terlipressin On the Aquaretic System Evidence of Antidiuretic Effects Aleksander Krag*, Flemming Bendtsen, Erling B. Pedersen, Niels-Henrik Holstein-Rathlou, Søren Møller

S1963

Driving Impairment Is Seen in Patients with Overt Hepatic Encephalopathy Despite Response to Therapy Jasmohan S. Bajaj*, Muhammad Hafeezullah, Raymond G. Hoffmann, Kia Saeian

S1964

Patients with Minimal Hepatic Encephalopathy Have Poor Insight Into Their Driving Skills Jasmohan S. Bajaj*, Muhammad Hafeezullah, Raymond G. Hoffmann, Thomas A. Hammeke, Kia Saeian

S1965

S1966

S1967

S1968

S1969

S1970

Small Intestinal Bacterial Overgrowth of Colonic-Type Carbohidrates Fermentative Bacteria in Cirrhotic Patients Giuseppe Merra*, Antonio Dal Lago, Emidio Scarpellini, Rosalba Finizio, Michele Santoro, Maria Grazia Spitilli, Ernesto Cristiano Lauritano, Maurizio Gabrielli, Venanzio Valenza, Giovanni Gasbarrini, Giovanni Ghirlanda, Antonio Gasbarrini

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

EOSINOPHILIC ESOPHAGITIS AND GASTROENTERITIS Participants will be able to: • Learn about progress in UGI disorders with eosinophilia. S1971



Comparison of Demographic, Endoscopic and Histologic Features in EoE Patients with and Without GERD Carol Garrean*, Nirmala Gonsalves, Ikuo Hirano

S1972

Increasing Incidence of Eosinophilic Esophagitis: A Persistent Trend After Accounting for Procedure Indication and Biopsy Rate Evan S. Dellon*, Wood B. Gibbs, John T. Woosley, Tara C. Rubinas, Nicholas J. Shaheen

S1973

Differences in Demographic and Clinical Characteristics of Eosinophilic Esophagitis in Urban and Rural U.S. Populations Umaprasanna Karnam*, Nirmala Gonsalves, Ikuo Hirano

S1974

Effectiveness of Oral Budesonide Suspension in Adult Patients with Eosinophilic Esophagitis Umaprasanna Karnam*, Ikuo Hirano

S1975

Distinct Morphologic Features, Classification Consideration and Clinical Correlation in a Large Cohort of Eosinophilic Esophagitis: A Single Center Study of 270 Adults Deepa Patil*, Nirmala Gonsalves, Ikuo Hirano, Guang Yu Yang

S1976

Eosinophilic Oesophagitis: Association with HLA-DQ2 and HLA-DQ8 Barry Lipschitz

S1977

Secular Trends in the Epidemiology and Outcomes of Eosinophilic Esophagitis in Olmsted County, Minnesota (1976-2007) Ganapathy A. Prasad*, Thomas C. Smyrk, Cathy Schleck, Alan R. Zinsmeister, G. Richard Locke, Jeffrey A. Alexander, Nicholas J. Talley

S1978

Long Term Response to Topical Corticosteroid (TCS) Therapy in a Cohort of Children with Eosinophilic Esophagitis (EE) Kenneth B. Quinto*, Ranjan Dohil, John Bastian, Bryce Arii, Robert Newbury, Seema Aceves

S1979

Eosinophilic Esophagitis, Barrett Esophagus, and Dysplasia Is There a Relationship? Sami R. Achem*, Cristina Almansa, Kenneth R. DeVault, Murli Krishna, Herbert C. Wolfsen

S1980

Incidence of and Risk Factors for Renal Dysfunction in Hospitalized Patients with Liver Cirrhosis Anna Cederborg*, Evangelos Kalaitzakis, Axel Josefsson, Einar Bjornsson

Prevalence of Eosinophilic Esophagitis in An Adult Population Undergoing Upper Endoscopy: A Prospective Study Ganesh R. Veerappan*, Joseph L. Perry, Timothy J. Duncan, Thomas P. Baker, Corinne Maydonovitch, Jason M. Lake, Roy K. Wong, Eric M. Osgard

S1981

Patient and Family Attitudes Towards Screening Endoscopy for Children with Portal Hypertension Juan C. Gana*, Constance O'Connor, Simon C. Ling

Eosinophilic Esophagitis and Gastroesophageal Reflux: Independent or Interactive Relationship? Mary Kovalak*, Kathryn A. Peterson, Kristen Thomas, Mae F. Go, Barbara Chadwick, Frederic Clayton, John C. Fang

S1982

Rising Incidence of Eosinophilic Esophagitis in the Calgary Health Region: A Population-Based Study Chadwick I. Williams*, Marc P. Dupre, Gilaad G. Kaplan, Christopher N. Andrews, Eldon A. Shaffer, Paul L. Beck

Effects of I.V. Albumin Substitution in Patients with Hepatic Cirrhosis and Hypoalbuminemia On the Clearance of Cholyl-Lysyl-Fluorescein As a Marker of Hepatic Dysfunction Hans-Jurgen Gruss Oxidized Albumin Is Associated with Water Retention and Severity of Disease in Patients with Liver Cirrhosis Masahiro Sakata*, Takumi Kawaguchi, Eitaro Taniguchi, Minoru Itou, Mitsuhiko Abe, Chikatoshi Yanagimoto, Ichirou Miyajima, Hironori Koga, Masaru Harada, Tetsuharu Oriishi, Michio Sata Efficacy of Topical Testosteron Gel Treatment On Muscle Strength and Bone Mineral Density in Men with Liver Cirrhosis Alper Yurci*, Mehmet Yücesoy, Kursad Unluhizarci, Edip Torun, Sebnem Gursoy, Mevlut Baskol, Kadri Guven, Omer Ozbakir

Denotes DDW Poster of Distinction

P-181

S U N D A Y MAY 18

POSTER SESSIONS—COMBINED S1983

Narrow Band Imaging May Improve the Sensitivity of Endoscopy for Diagnosing Eosinophilic Esophagitis Shanti L. Eswaran*, Nirmala Gonsalves, Ikuo Hirano

S1984

Clinical, Endoscopic, Histological and Therapeutic Spectrum of Eosinophilic Esophagitis in a French Pediatric Population: A Review of 9 Years. What About Endoscopic Balloon Dilation? Carlos Robles-Medranda*, Hannah P. Lukashok, Christine Rivet, Catherine Le-Gall, Raymonde Bouvier, Jerome Dumortier, Alain Lachaux

AGA Institute Poster Session 8:00 AM - 5:00 PM

S1993

The Role of JC Virus in Colorectal Neoplasia Occurring After Liver Transplantation Michael Selgrad*, Jan J. Koornstra, Lucia Fini, Elizabeth B. Haagsma, Marloes R. Blom, Gerard Dijkstra, Robert C. Verdonk, S. de Jong, Sharenda Williams, Richard L. Meyer, Ajay Goel, Luigi Ricciardiello, C. R. Boland

S1994

JC Virus Is Present in H. pylori Induced Gastritis and Gastric Cancer Michael Selgrad*, Thomas Wex, Doerthe Kuester, Gerhard Treiber, Albert Roessner, Luigi Ricciardiello, Peter Malfertheiner, Ajay Goel, C. R. Boland

S1995

Cross-Talk of β-Catenin and AKT Signaling Pathways in Helicobacter pylori Infected Gastric Epithelial Cells SangHun Lee

S1996

Role of Chronic Inflammation in Sporadic Colorectal Neoplasia Mairi H. McLean*, Janice E. Drew, Claus D. Mayer, Andrew Farquharson, Lawrence N. Barrera, Nicky Fyfe, Graeme I. Murray, Georgina Hold, Norman A. Mowat, Emad El-Omar

S1997

Paxillin Produces a Molecular Switch to Converge Helicobacter pylori-Induced Intracellular Signaling Fazal H. Tabassam*, David Y. Graham, Yoshio Yamaoka

S1998

Sustained Procoagulant and Inflammatory Response Following Esophagectomy, and the Impact of Neoadjuvant Chemoradiation Miriam Byrne*, John V. Reynolds, Donal Hollywood, Graham P. Pidgeon, Barry White, Narayanasamy Ravi, Patrick J. Byrne

S1999

Tumor Suppressor FOXO3A Is Involved in TNFαInduced Regulation of IL-8 in Intestinal Epithelial Cells Lobke Snoeks, Christopher R. Weber, Kaarin Wasland, Suzana D. Savkovic*

S2000

Expression of Apurinic/Apyrimidinic Endonuclease-1 (APE-1) in H. pylori Associated Gastritis, Gastric Adenoma and Gastric Cancer Seiji Futagami*, Tetsuro Hiratsuka, Tomotaka Shindo, Tatsuhiko Hamamoto, Masafumi Kusunoki, Kazumasa Miyake, Taku Tsukui, Katya Gudis, Sheila E. Crowe, Choitsu Sakamoto

S2001

Not Only Reflux Esophagitis But H. pylori Infection May Be a Causal Factor for the Gastroesophageal Junction Cancer in Japanese People Tomoyuki Koike*, Shuichi Ohara, Yasuhiko Abe, Toru Horii, Katsunori Iijima, Akira Imatani, Tooru Shimosegawa

S2002

Impact of Vitamin C Supplementation On Regulators of Esophageal Inflammation and Carcinogenesis Mahwash Babar*, John V. Reynolds

S2003

Synergistic Effects of Progastrin (PG) and Citrobacter Rodentium (Cr) On the Growth of Proximal and Distal Colonic Epithelial Cells in FVB/N Mice: Associated Changes in the Levels of β-Catenin, NF-κB and ERK1/2 Shahid Umar*, Pomila Singh

S2004

Okadaella Gastrococcus-Like Immunoreactivity Found in the Pre-Neoplastic Gastric Mucosa Takayuki Okada*, Kazutoshi Hori, Graham Adkins, Hiroto Miwa

S2005



Colon Cancer Screening Practices At An HIV Outpatient Clinic: A Six Year Analysis Ryan M. Ford*, Ashley L. Reid, Matthew Mcmahon, Ruchir P. Patel, Elizabeth Nesmith, Jeffrey Lennox, Irfan Alhayani, Kamil Obideen, Mohammad A. Wehbi

S2006

Comparative Whole Genome Expression Analysis in Experimental Models of Colitis Associated and Sporadic Colon Cancer Clemens Neufert*, Christoph Becker, Peter R. Galle, Oezlem Tuereci, Ugur Sahin, Markus F. Neurath

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: IBD, INFECTION, INFLAMMATION AND GI CANCERS Participants will be able to: • Familiarize themselves with IBD, infection, inflammation and GI cancers.

S U N D A Y MAY 18

S1985

Inhibition of PI3K Suppresses Inflammation-Mediated Colon Cancer in Mice Takaaki Tsushimi*, Hiroshi Saito, B. M. Evers

S1986

High Versus Low Doses of 5-Aminosalicylates On Duration of Time Until Development of Colorectal Cancer in Patients with Ulcerative Colitis Vernon J. Carriere*, Robert A. Oster, Alexandra Gutierrez

S1987

Protective Role of 5-Asas Against Colorectal Cancer and Dysplasia in Crohn's Disease - Effect of Dose and Duration of Therapy. a Retrospective Case Control Study Rajan Kochar*, Robert A. Oster, Alexandra Gutierrez

S1988

Cyclooxygenase Inhibitors Downregulate P-Glycoprotein in Human Colorectal Adenocarcinoma Cells Afraa Zrieki*, Robert Farinotti, Marion Buyse

S1989

Colorectal Cancer in Inflammatory Bowel Disease Without Distant Dysplasia May Be a Specific Entity Stephan Brackmann*, Solveig Norheim Andersen, Geir Aamodt, Borghild Roald, Frøydis Langmark, Ole P. F. Clausen, Erling Aadland, Olav Fausa, Andreas Rydning, Morten H. Vatn

S1990

S1991

S1992



P-182

Sequential Analysis of Aberrant Crypt Foci (ACF) By Endoscopic Examination of Azoxymethane-Induced Colitis-Associated Mouse Colorectal Tumors Masayuki Fukata*, Yasmin Hernandez, Keith J. Breglio, Daisy E. Conduah, Anli Chen, Ruliang Xu, David Hsu, Ryan Ungaro, Hisao Tajiri, Maria T. Abreu The Tumor Specific Markers TKT11 and DNase X in Colon Carcinoma Cell Lines, Primary Epithelial Cells and Mice Susanne Bentz*, Esther Endlicher, Florian Obermeier, Rainer Wittig, Peter Schubert, Martin Hausmann, Michael Fried, Gerhard Rogler Induction of Krüppel-Like Factor 5 By Lipopolysaccharide in Intestinal Epithelial Cells Is Mediated By Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways Sharon K. Ngwenya*, Agnieszka Bialkowska, Vincent W. Yang

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED S2007



Bacterial Microbiota Fingerprints Are Altered in Colon Cancer Ece A. Mutlu*, Sarah C. Glover, Patrick M. Gillevet, Xavier Llor, Carline R. Quander, Masoumeh Sikaroodi, Phillip Engen, Samuel Bracamonte, Ali Keshavarzian

AGA Institute Poster Session 8:00 AM - 5:00 PM

S2018

Are Gastrointestinal Carcinoid Tumors Associated with a High Incidence of Extra-Gastrointestinal Malignant Tumors? Gaurav Aggarwal*, Cristina S. Marin, Jahnavi Naik, Emad Qayed, Qiang Cai

S2019

Elevated Serum Ang-2 in Neuroendocrine Tumor Patients Is Associated with Metastatic Spread and Represents a Negative Prognostic Predictor Antje Deters, Annett Rexin, Bertram Wiedenmann, Arne Scholz*

S2020

Purine Nucleotide Analogs (PNA) Do Not Improve the Outcome of Enteropathy Associated T-Cell Lymphoma (EATL) in Comparison with Standard Chemotherapy: A Retrospective Multicenter Study Aurelien Amiot*, Matthieu Allez, Xavier Treton, Lionel Galicier, Francisca Joly, Jean-Marc Gornet, Bernard Messing, Eric Oksenhendler, Marc Lemann, Yoram Bouhnik

S2021

Clinical and Endoscopic Analysis of Primary T Cell Lymphoma of the Gastrointestinal Tract According to Pathology and EBV Status Do Hoon Kim*, Seung-Jae Myung, Jeong-Sik Byeon, Seunghyun Kwon, Byunggyu Kim, Soon Man Yoon, Mi Young Do, Byong Duk Ye, Ho June Song, Hwoon-Yong Jung, Suk-Kyun Yang, Jin-Ho Kim

S2022

Co-Expression of Somatostatin and Dopamine Receptors in Neuroendocrine Tumours, An Immunohistochemical Study Rajaventhan Srirajaskanthan*, Jennifer Watkins, Martyn Caplin

S2023

Alpha Fetoprotein and Human Chorionic Gonadotrophin-β Are Prognostic Tumour Markers in Patients with Neuroendocrine Tumours Tahir Shah, Rajaventhan Srirajaskanthan*, Maninder Bhogal, Christos Toumpanakis, Tim Meyer, Aneesha Noonan, Caroline Witney-Smith, Tejal Amin, Pervinder Bhogal, Niroshan Sivathasan, Ben d. Warner, Martyn Caplin

S2024

Comparison of 68GA-Octreotate-PET and (111in)Pentetreotide Scintigraphy (Octreoscantm)-SPECT in Patients with Neuroendocrine Tumours Rajaventhan Srirajaskanthan*, Jade Soh, Ann-Marie Quigley, Christos Toumpanakis, John Buscombe, Martyn Caplin

S2025

Expression of the EGFR Family of Receptors (EGFR, HER-2, HER-3 and HER-4) in Neuroendocrine Tumours Rajaventhan Srirajaskanthan*, Tahir Shah, Jennifer Watkins, Laura Marelli, Korsa Khan, Martyn Caplin

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: LYMPHOMA, NEUROENDOCRINE AND STROMAL TUMORS Participants will be able to: • Evaluate lymphoma, neuroendocrine and stromal tumors in GI oncology. S2008



A Mouse Model of Human Multiple GIST Family with Kit-Asp820tyr Mutation Generated By Knock-in Strategy Norihiro Nakai*, Toshihiro Okada, Koushi Oh, Mayumi Shincho, Takashi Ito, Ikuo Matsuda, Jiro Fujimoto, Seiichi Hirota

S2009

The Carcinoid Cell Line BON Secretes Factors That Increase Proliferation of Human Colonic and Cardiac Fibroblasts Scott R. Silva*, L. A. Chen, Hung Q. Doan, Courtney M. Townsend, B. M. Evers

S2010

Outcome and Quality of Life Favor a Conservative Treatment of Patients with Primary Gastric Nhl's. Results of a Prospective Randomized Study Wolfgang Fischbach*, Mariele Goebeler, Stefanie Schramm

S2011

Value of Routine Capsule Endoscopy in the Strategy of Patients with Primary Gastric Non-Hodgkin'sLymphoma Wolfgang Fischbach*, Christoph G. Dietrich, Oliver H. AlTaie

S2012

HOXC6 Is Overexpressed in Gastrointestinal Carcinoids and Interacts with JunD to Regulate Tumor Growth Kotoyo Fujiki*, Eva-Maria Duerr, Hirotoshi Kikuchi, Aylwin Ng, Ramnik J. Xavier, Yusuke Mizukami, Takaaki Imamura, Matthew H. Kulke, Daniel Chung

S2013

Long-Term Clinical Outcome of Helicobacter pyloriNegative Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Is Comparable to That of H. pylori-Positive Lymphoma Su Jin Chung*, Joo Sung Kim, Hansoo Kim, Sang Gyun Kim, Hyun Chae Jung, In Sung Song

S2014

S2015

Gastric Lymphoma in France: A Population-Based Study Arlette Danzon, Aurélien Belot, Anne Claire Dupont Gossart, Eric Deconinck, Franck Carbonnel*

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology



Molecular Identification of the SNARE Proteins Syntaxin 3, SNAP 23 and Cellubrevin (VAMP 3) in the Gastrointestinal Mucosa, Hepatopancreatic Tissues and Neuroendocrine Tumors Stephanie Kaemper, INes Eichhorn, Yvonne Giesecke, Bertram Wiedenmann, Carsten Grotzinger*

S2016

Epidemiology of Sporadic Pancreatic Neuroendocrine Malignant Tumors Ananya Das

S2026

Relationship of Type 2 Diabetes to Clinical Course of Colorectal Cancer Ali Siddiqui*, Byron L. Cryer, Bertis Little

S2017

Assessment and Outcomes in Gastric Carcinoid Laura Marelli*, Christos Toumpanakis, Rajaventhan Srirajaskanthan, Timothy Eves, Jennifer Watkins, Martyn Caplin

S2027

The Visceral Fat Is Highly Associated with Colorectal Neoplasia Yutaka Yamaji*, Takao Kawabe, Toru Mitsushima, Masao Omata

GI ONCOLOGY: OBESITY, NUTRITION AND ENVIRONMENT IN GI CANCERS Participants will be able to: • Evaluate the roles of obesity, nutrition and environment in GI cancers.

Denotes DDW Poster of Distinction

P-183

S U N D A Y MAY 18

POSTER SESSIONS—COMBINED S2028

MAY 18

S2037

ES Cell Specific RAS, Eras in Gastric Cancer Accelerates Its Liver Metastasis Eiji Kubota*, Hiromi Kataoka, Makoto Sasaki, Tsuneya Wada, Takaya Shimura, Tsutomu Mizoshita, Takashi Joh

S2038

An Improved Staging System for Esophageal Adenocarcinoma Based On the Number of Involved Lymph Nodes Christopher J. Peters*, Richard H. Hardwick, Jonathan R. Rees, Sarah L. Vowler, Peter M. Safranek, Vicki Save, Nicholas Carroll, Simon Dwerryhouse, Nasreen Imrit, Nicholas Maynard, Geoffrey W. Clark, Rebecca Fitzgerald

S2039

Early Dose Reduction of Gemcitabine Based On Adverse Events Is Not Associated with the Survival of the Patients with Pancreatic Cancer Ken Hirao*, Hirofumi Kawamoto, Ryo Harada, Koichiro Tsutsumi, Masakuni Fujii, Hironari Kato, Naoko Kurihara, Osamu Mizuno, Etsuji Ishida, Tsuneyoshi Ogawa, Hirotoshi Fukatsu, Jun Kato, Hiroyuki Okada, Kazuhide Yamamoto

S2040

Tumor Infiltrating Lymphocytes and RHAMM Expression Predict Prognosis in Patients with Rectal Cancer Inti Zlobec*, Luigi Terracciano, Shajan Peter, Lukas Degen, Christoph Beglinger, Alessandro Lugli

S2041

Biological Marker Expression Selects a Subgroup of Early Rectal Cancer Patients for Pre-Operative Therapy Inti Zlobec*, Luigi Terracciano, Shajan Peter, Lukas Degen, Christoph Beglinger, Alessandro Lugli

S2042

Defining Carcinoma Risk in Barrett Patients - Known Risk Factors May Be Less Important Katharina Wrobel, Christian Bojarski, Winfried A. Voderholzer, Kathrin Rothe, Bertram Wiedenmann, Thomas Roesch, Heiko Pohl*

CD8+ T Cell Infiltration and Decreased FOXP3+ Regulatory T Cell Numbers in the Primary Tumor Predict for Survival in Gastric Cancer Patients Victoria S. Lee, Kiat-Hon Lim, Khoon-Lin Ling*

S2043

Body Mass Index and the Risk of Barrett's Esophagus: A Systematic Review and Meta-Analysis Paresh Kamat*, Sijin Wen, Jeffrey S. Morris, Sharmila Anandasabapathy

Pathological Predictors for Metastasis in T1 Colorectal Cancer Using Immunohistochemical and Elastica Van Gieson Staining Akifumi Suzuki*, Kazutomo Togashi, Mitsuhiro Nokubi, Yasuyuki Miyakura, Hisanaga Horie, Yoshikazu Yasuda

S2044

Selecting Patients for Post-Surgical Therapy in Rectal Cancer: Should We Rely On Endorectal Ultrasonography or On Histopathological Study? Results from a Randomised Multicenter Trial By the FFCD Pascal Burtin*, Nicolas Methy, Jean-Pierre Gérard, Olivier Bouché, Thierry Conroy, Olivier Chapet, Franck Bonnetain

S2045

Collagen XVII and Cathepsin B - Two Candidate Genes Influencing Migration, Invasion and Metastasis in Genetically Generated Oral-Esophageal Cancer Cells Heike Kunert*, Sarah Hauss, Angela Queisser, Claus W. Franzke, Eva Egenter, Nina Hirt, Michaela Thaler, Steffen Heeg, Thomas Reinheckel, Leena Bruckner-Tudermann, Christoph Peters, Hubert E. Blum, Oliver G. Opitz

S2046

Peroxisome Proliferator Activated Receptor α (PPARα) in Colon Cancer Anthony Shonde*, Karen M. McCartney, David R. Bell, Robert Goodlad, Andrew Bennett, Christopher J. Hawkey

S2047

Adiponectin Suppresses Colorectal Carcinogenesis Induced By High-Fat Diet via AMP Protein Kinase Nobutaka Fujisawa*, Atsushi Nakajima

S2048

Basal ERK1/2 Signaling Induces Anoikis in Colorectal Carcinoma Cells Following Constitutive Re-Expression of the Chemokine Cxcl12 Michael K. Wendt, Luke Drury*, Rebecca A. Vongsa, Michael B. Dwinell

S2049

Loss of Rab25 Promotes Intestinal Neoplasia Ki-Taek Nam, Hyuk-Joon Lee, Robert J. Coffey, Timothy J. Yeatman, Bruce J. Aronow, James R. Goldenring*

S2029

Cellular Iron Regulation Is Defective in Colorectal Adenocarcinoma Matthew J. Brookes*, Keith Roberts, Tariq Iqbal, Chris Tselepis

S2030

Opium, Tobacco and Alcohol Use in Relation to Esophageal Cancer in a High-Risk Area of Iran Dariush Nasrollahzadeh, Farin Kamangar, Karim Aghcheli, Masoud Sotoudeh, Farhad Islami, Christian C. Abnet, Ramin Shakeri, Akram Pourshams, Haji Amin Marjani, Noushin Taghavi, Seyed Mehdi Nouraie, Reza Ansari, Morteza Khatibian, Naser Keramat, Saman Fahimi, Abdolazim Khozeini, Rahmat Ghaziani, Siavosh NasseriMoghaddam, Ali Yoonessi, Paolo Boffetta, Reza Malekzadeh*, Sanford M. Dawsey

S2031

S U N D A Y

Relationship Between Obesity and Colorectal Adenoma in Asymptomatic Adults Ja Seol Koo*, Jai Hong Ahn, Jin Nam Kim, Sun Min Park, Ik Yoon, Dong Il Kim, Sung Woo Jung, Hyung Joon Yim, Yoon Tae Jeen, Hong Sik Lee, Sang Woo Lee, Jai Hyun Choi, Chang Duck Kim, Ho Sang Ryu

S2032

S2033

Socioeconomic Status in Relation to Esophageal Cancer in a High-Risk Area of Iran Farhad Islami, Farin Kamangar, Dariush Nasrollahzadeh, Masoud Sotoudeh, Christian C. Abnet, Karim Aghcheli, Behnoush Abedi Ardekani, Ramin Shakeri, Shahryar Semnani, Shahin Merat, Akram Pourshams, Siavosh Nasseri-Moghaddam, Homayoun Vahedi, Alireza Sepehr, Arash Etemadi, Mohammad Hasan Barazandeh, Abdolhakim Ebadati, Noorli Radgohar, Hafez Fakheri, Rabaeh Rajabzadeh, Paolo Boffetta, Sanford M. Dawsey, Reza Malekzadeh*

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: PROGNOSIS, CARCINOGENESIS AND METASTASIS Participants will be able to: • Review recent research in prognosis, carcinogenesis and metastasis. S2034



Combined Analysis of Lymph Node Status, Vascular Invasion, Tumor Budding and Tumor Infiltrating Lymphocytes Is Highly Predictive of Local Recurrence in Mismatch Repair-Proficient Colon Cancer Inti Zlobec, Kristi Baker, Parham Minoo, Luigi Terracciano, Alessandro Lugli*

S2035



Long Term Trends in Incidence and Mortality Due to Small Bowel Malignancy in the U.S. Population Sarah A. Rodriguez*, Douglas O. Faigel

S2036

Pro-Apoptotic Bad and Bid Protein Expression Predict Survival in Stage II and III Colon Cancer Patients Frank A. Sinicrope*, Rafaela L. Rego, Nathan R. Foster, Stephen N. Thibodeau, Steven R. Alberts, Daniel J. Sargent

P-184

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED S2050

S2051

S2052

Prostanglandin E2 Receptors Are Involved in NicotineInduced Gastric Tumor Growth Vivian Y. Shin*, Wai K. Leung, Chi-Hin Cho, Joseph J. Sung

AGA Institute Poster Session 8:00 AM - 5:00 PM

SIRNA-Mediated Reduction of α-Actinin-1 Inhibits Pressure-Induced Murine Tumor Cell Wound Implantation and Enhances Tumor-Free Survival David H. Craig*, Christina Downey, Marc D. Basson

Sponsored by: Liver & Biliary

c-Jun Nh2-Terminal Kinase 1 Is a Critical Regulator for the Development of Chemical-Induced Gastric Cancer in Mice Shin Maeda*, Wataru Shibata, Yohko Hikiba, Ayako Yanai, Kei Sakamoto, Hayato Nakagawa, Keiji Ogura, Michael Karin, Masao Omata

Participants will be able to: • Learn current guidelines for the treatment of chronic hepatitis b infection; and • New developments in mechanisms of chronic liver disease.

S2053

Downregulation of PTP-PEST By shRNA in Colon Cancer Cells May Disrupt Cell-Cell Adhesion and Promotes Migration William Rengifo-Cam*, Rosario Espejo, Sarita K. Sastry

S2054



A Novel Mouse Model of Sporadic Colorectal Cancer Kenneth Hung*, Larissa Georgeon Richard, Alexandra Kunin, Umar Mahmood, Raju Kucherlapati

S2055

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) Is a Potential Biomarker for Peritoneal Metastasis of Gastric Cancer Lydia K. Lung*, Angela M. Hui, Billy C. Leung, George G. Chen, Enders K. Ng

S2056

S2057

S2058

S2059

Mucosally-Adherent E. coli Isolates from Human Colon Cancer Induce Nuclear Translocation of β-Catenin and COX-2-Dependent Cyclin D1 Expression in Human Colon Cancer Epithelial Cells Paul D. Collins*, Lu-Gang Yu, Jonathan M. Rhodes A Loss of Symbiosis with Certain Strains of Commensal E. coli Leads to Increased Colon Cancer Invasion in An In Vitro Colon Cancer Model Via Activation of Rac and MMP-1 Sarah C. Glover*, Marinka Bulic, Ramana V. Vishnubhotla, V. K. Viswanathan, Michael Cho, Jennifer L. Roxas, Rebecca Mecum, Igor Titushkin cagA C-Terminal Variations in Helicobacter pylori Strains from Colombian Patients with Gastric Precancerous Lesions Liviu A. Sicinschi*, Pelayo Correa, Richard M. Peek, M. Constanza Camargo, M. Blanca Piazuelo, Judith RomeroGallo, Uma S. Krishna, Alberto Delgado, Luis E. Bravo, Barbara G. Schneider A 17-Year Delay of Development of Intestinal Type Adenocarcinoma in Females Explains Male Predominance of Upper Gastrointestinal Cancer Mohammad H. Derakhshan, Sarah Liptrot, Douglas Morrison, Ian L. Brown, Kenneth E. McColl*

S2060

Aberrant Expressions of Gastric Type Mucin and Claudin in Colorectal Serrated Polyps Shizuki Takemura*, Ryoji Kushima, Takanori Hattori

S2061

Uniparental Disomy As Novel Mutational Mechanism in MSI- and CSI-Colorectal Cancer Waltraud Zopf, Elena Hartmann, Theodor Kudlich, Oliver Al-Taie, Hardi Luehrs, Andreas Rosenwald, Wolfgang M. Scheppach, Michael Scheurlen, Ralph Melcher*

S2062

Secondary Linitis Plastica of the Rectum: EUS Features and Tissue Sampling Ferga C. Gleeson*, Jonathan E. Clain, Elizabeth Rajan, Mark D. Topazian, Kenneth K. Wang, Maurits J. Wiersema, Lizhi Zhang, Michael J. Levy

S2063

Sails Pavilion San Diego Convention Center

CLINICAL HEPATITIS: ETIOLOGY, DIAGNOSIS, AND MANAGEMENT

S2064

Diagnosis of Cirrhosis in Alcoholic Liver Disease (ALD): Is There a Place for Transient Elastography? Sebastian Mueller*, Gunda Millonig, Stefanie Friedrich, Andreas Welker, Peter Becker, Frank Reimann, H. Eisele, Felix Stickel, Helmut-Karl Seitz

S2065

Minimal Visceral Fat Accumulation Is a Prerequisite for a Persistent Normal Serum ALT Level in Chronic Hepatitis C Patients Noriko Oza*, Yuichiro Eguchi, Shunya Nakashita, Eriko Ishibashi, Takahisa Eguchi, Aki Matsunobu, Yoichiro Kitajima, Shigetaka Kuroki, Iwata Ozaki, Yasunori Kawaguchi, Yasushi Ide, Tsutomu Yasutake, Ryuichi Iwakiri, Toshihiko Mizuta, Naofumi Ono, Kazuma Fujimoto

S2066

In Vitro Evaluation of Hepatic Transdifferentiation of Adipose and Bone Marrow-Derived Stromal Cells Nathalie Saulnier*, M. Puglisi, M. Barba, Anna C. Piscaglia, Marialuisa Novi, Ernesto Cristiano Lauritano, S. Alfieri, G. Leone, Giovanni Gasbarrini, Antonio Gasbarrini

S2067

Histological Attributes of Chronic Portal Hepatitis and Cholangitis in Patients with Ttv-Monoinfection Leonid B. Lazebnik, Sergej G. Khomeriki*

S2068

Histopathological Study of Chronic Hepatitis B: A Comparative Study of Ishak and Metavir Scoring Systems Mehdi Mohamadnejad*, Seyed Mohamad Tavangar, Farid Kosari, Mohamad Khosravi, Ghodratollah Montazeri, Arezoo Estakhri, Mohammad Mahdi Mirnasseri, Atoosa Fazlollahi, Shahram Agah, Reza Malekzadeh

S2069

Quantitative Measure of Liver Function Using 13CGalactose (GBT) and 13C-Methacetin (MBT) Breath Tests and Hyaluronic Acid As Serum Markers in Patients with Chronic Hepatitis B or Chronic Hepatitis C Krista Stibbe, Claudia Verveer, Jan Francke, Bettina E. Hansen, Pieter E. Zondervan, Ernst J. Kuipers, Robert J. de Knegt, Anneke van Vuuren*

S2070

Prevalence of anti-HBs Antibody and Rate of HBV Vaccination Among Non HBV-Related Cirrhotic Patients Sandrine Baubet, Anne-Marie Marion-Audibert, Sylvie Radenne, Emmanuel Maillard, Denis Pere-Verge, Fabien Zoulim, Christian Trepo, Jean Christophe Souquet*

S2071

Vietnamese Patients with Chronic Hepatitis B (CHB) Exhibit Different Viral Genotype Distributions Than Chinese Patients Long H. Nguyen*, Nghiem B. Ha, Philip Vutien, Nghi B. Ha, Ruel T. Garcia, Huy N. Trinh, Huy A. Nguyen, Khanh K. Nguyen, Brian S. Levitt, Emmet B. Keeffe, Mindie H. Nguyen

S2072

Clinical Characteristics and Prognostic Factors of DrugInduced Liver Injury in Korea Ok-Jae Lee*, Kyung-Ah Jung, Hyun-Joo Min, Hyun-Jin Kim, Tae-Hyo Kim

The Spectrum of Therapies for Esophageal Carcinoma Gregory S. Cooper*, Tzuyung D. Kou, Amitabh Chak

Denotes DDW Poster of Distinction

P-185

S U N D A Y MAY 18

POSTER SESSIONS—COMBINED S2073

The Reproducibility of Transient Elastography in Patients with Chronic Liver Diseases Sergey Morozov*, Yulia M. Trufanova, Vasiliy A. Isakov, Boris S. Kaganov

S2074

The Expression of Hedgehog Pathway in Extrahepatic Cholangiocarcinoma Yoon Jae Kim*, Seungmin Bang, Kyung Hwa Park, Jeong Youp Park, Jae Hee Cho, Jae Bock Chung, Si Young Song, Seung Woo Park

S2075

S2076

S2077

S U N D A Y

Prevalence of HBV DNA Polymerase (B-DNA Pol) Mutations in 345 Patients with Treatment-Naïve Chronic Hepatitis B (CHB) Mindie H. Nguyen*, Huy N. Trinh, Ruel T. Garcia, Long H. Nguyen, Philip Vutien, Nghiem B. Ha, Huy A. Nguyen, Khanh K. Nguyen, Emmet B. Keeffe, Nghi B. Ha Age≥35 Years Is a Predictor of Significant Histology in Chronic Hepatitis B (CHB) Patients with Normal ALT Even with Stricter Cut-Offs (≤30 for Men and ≤19 for Women) Mindie H. Nguyen*, Huy N. Trinh, Ruel T. Garcia, Jeanine Phan, Nghiem B. Ha, Gerald A. Weiss, Khanh K. Nguyen, Huy A. Nguyen, Emmet B. Keeffe



Almost Half of the Chronic Hepatitis B (CHB) Patients with Positive HBeAg Have Confirmed Precore and/or Basal Core Promoter (PreC/BCN) Mutations Mindie H. Nguyen*, Huy N. Trinh, Ruel T. Garcia, Long H. Nguyen, Nghiem B. Ha, Philip Vutien, Huy A. Nguyen, Khanh K. Nguyen, Emmet B. Keeffe

S2078

The APRI and Fib-4 Are Equivalent in the Estimation of Fibrosis in Chronic Hepatitis C Ned Snyder*, Tony Trang, Shu-Yuan Xiao, John R. Petersen

S2079



The Impact of Hepatitis B (HBV), Hepatitis C (HCV) and Non-Alcoholic Fatty Liver Disease (NAFLD) Guidelines On Clinical Practices Jillian Kallman, Aimal Arsalla, Angela M. Wheeler, Ruben D. Aquino, Kathy L. Terra, Rebekah Euliano, Zobair M. Younossi*

S2080

Outcome of Pediatric Autoimmune Hepatitis Maria Triantafyllopoulou*, Karan McBride Emerick, Hector Melin-Aldana, Peter F. Whitington

MAY 18

S2081

S2082

S2083

Peginterferon and Ribavirin for Treatment of Hepatitis C and HIV Co-Infection: A Meta-Analysis of Randomized Controlled Trials Ajitinder S. Grewal*, Abhishek Choudhary, Matthew L. Bechtold, Srinivas R. Puli, Mohamed O. Othman, Praveen K. Roy Viral Kinetics During Adefovir in Treatment NaÏVe Chronic Hepatitis B (CHB) Patients Hissar Syed*, Eva Herrmann, Manoj Kumar, Mei Fang Ong, Shiv Kumar Sarin Outcome of HCV Therapy in Patients with Schizophrenia and/or Bipolar Disorder Fatma Barakat*, Deanna Oliver, Lita Petcharaporn, Meghan Carlson, Lisa Richards, Ed Barber, Elliot Alpert, Khaled Selim, William Perry, Tarek Hassanein

S2084



Significant Prevalence of Histologic Disease in Chronic Hepatitis B Patients with Mildly Elevated Serum Alanine Aminotrasferase Levels Philip S. Tsang*, Ruel T. Garcia, Huy N. Trinh, Jeanine Phan, Nghiem B. Ha, Huy A. Nguyen, Khanh K. Nguyen, Emmet B. Keeffe, Mindie H. Nguyen

S2085

Prevalence of Celiac Disease in Established Liver Disease and Cryptogenic Transaminase Elevation: A Systematic Review Erin McGeeney*, Bruce R. Bacon, Fasiha Kanwal

P-186

S2086

Autoimmunity in Sclerosing Cholangitis (SC): Association SC with Autoimmune Pancreatitis (SC-AIP) and PSC Kazuichi Okazaki*, Hideaki Miyoshi, Kazushige Uchida

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Pancreatic Disorders

PANCREATITIS: GENETIC STUDIES Participants will be able to: • Understanding the impact of genetic factors in the pathogenesis of pancreatic disorders. S2087

Does Presence of SPINK-1 Variant Alter the Course of Pancreatitis? Bimaljit S. Sandhu*, Shelley C. Smith, Andres D. Mogollon, Patrik Vitazka, Andrea Ferreira-Gonzalez, Alvin M. Zfass, Doumit BouHaidar, Arun J. Sanyal

S2088

TLR2, TLR4, and CD14 Polymorphisms Are Associated with Acute Pancreatitis in Japan Yasuhiko Takagi*, Atsushi Masamune, Kiyoshi Kume, Tooru Shimosegawa

S2089

A Loss-of-Function Anionic Trypsinogen (PRSS2) Variant in Japanese Patients with Pancreatic Diseases Kiyoshi Kume*, Atsushi Masamune, Yasuhiko Takagi, Tooru Shimosegawa

S2090

SPINK1 N34s Is Not Associated with the Sentinel Acute Pancreatitis Episode But Predisposes Patients to Recurrent Attacks Elie Aoun*, Venkata Muddana, Janette Lamb, Michael M. Barmada, Georgios I. Papachristou, David C. Whitcomb

S2091

Does the Pain-Protective GTP Cyclohydrolase Haplotype Significantly Alter the Severity of Pain in Humans with Chronic Pancreatitis? Mark G. Lazarev*, Janette Lamb, Michael M. Barmada, David C. Whitcomb

S2092

Genetic Analysis of the Trypsin-Activated Receptor PAR2 in Chronic Pancreatitis Jonas Rosendahl*, Peter Kovacs, Susann Gebbers, Lena Selig, Felix Gundling, Falk Groeger, Hans Martin Heuer, Joachim Mossner, Volker Keim, Heiko Witt, Hans Bodeker

S2093

Epidermal Growth Factor +61 G/A Polymorphism and Serum Levels in Patients with Acute Pancreatitis Georgios I. Papachristou*, Venkata Muddana, Kim Corrado, Michael R. O'Connell, Adam Slivka, David C. Whitcomb

S2094

Visfatin Polymorphisms and Elevated BMI Interact to Increase the Susceptibility to Acute Pancreatitis Arun Sharma, Venkata Muddana, Janette Lamb, Adam Slivka, David C. Whitcomb, Georgios I. Papachristou*

S2095

The IL-6 -174 G/G Genotype Increases Susceptibility to Acute Pancreatitis (AP) in Obese Subjects Venkata Muddana*, Arun Sharma, Janette Lamb, Adam Slivka, David C. Whitcomb, Georgios I. Papachristou

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Nutrition & Obesity

REGULATION OF FOOD INTAKE, OBESITY, SATIETY Participants will be able to: • Learn more about regulation of food intake, obesity and satiety. S2095a



Leptin As a Substitute for Insulin Therapy in InsulinDeficient Diabetes: Correction of Hyperglycemia and Hyperphgia and Surviving Without Diabetic Complications Shinya Kojima*, Haruka Amitani, Marie Sameshima, Akihiro Asakawa, Akio Inui, Pushpa S. Kalra, Satya P. Kalra

S2095b

Gastric Phase 3 Is a Hunger Signal in the Interdigestive State in Man Daphne C. Ang, Heleen Nicolai, Rita Vos, Pieter Vanden Berghe, Daniel Sifrim, Inge Depoortere, Theo L. Peeters, Jozef Janssens, Jan F. Tack*

S2095c

Gastric Emptying Is Slower, and Hunger and Energy Intake Are Less, Pre-Ovulation When Compared with Post-Ovulation in Healthy Lean Women Ixchel M. Brennan, Kate L. Feltrin, Nivasinee S. Nair, Trygve Hausken, Tanya J. Little, Diana Gentilcore, Karen L. Jones, Michael Horowitz, Christine Feinle-Bisset*

S2095d

Gastric Bypass Surgery Causes Body Weight Loss Without Reducing Food Intake in Rats Marianne W. Furnes*, Karin A. Tømmerås, Carl-Jørgen Arum, Chun-Mei Zhao, Duan Chen

S2095e

S U N D A Y

Pharmacological Acceleration of Gastric Emptying Decreases Caloric Intake and Increases Postprandial Symptoms in Obese Subjects Sandra Torra Alsina*, Santiago Aguadé Bruix, Pilar Sunyé, Montserrat Andreu Garcia, Juan Ramon Malagelada, Sílvia Delgado-Aros

S2095f

Gastric Emptying in Mouse Models of Eating Disorders Michael R. Bardsley*, Andrea Lorincz, Laura Popko, Ferenc Izbéki, Gianrico Farrugia, Tamas Ordog

S2095g

The Intragastric Behaviour of Dietary Fat Strongly Influences Fat Absorption: Implications On Cholecystokinin Release and Appetite Jeroen Maljaars*, Martin Foltz, Harry PF Peters, Sheila Wiseman, Ad A.M. Masclee

S2095h

Adipocytes Express a Functional System for Serotonin Synthesis, Re-Uptake and Receptor Activation Kamilla A. Stunes, Janne E. Reseland, Oyvind Hauso, Mark Kidd, Karin A. Tømmerås, Unni Syversen, Bjorn I. Gustafsson*

S2095i

Acyl Ghrelin Improves Selective Serotonin Reuptake Inhibitor-Induced Gastrointestinal Motility in Rats Akihiro Asakawa*, Haruka Amitani, Marie Sameshima, Shinya Kojima, Mizuki Hayashi, Naoki Fujitsuka, Akio Inui

Denotes DDW Poster of Distinction

MAY 18

P-187

POSTER SESSIONS—CLINICAL CLINICAL AGA Institute Poster Session 8:00 AM - 5:00 PM

M1011

Predictive Factors for Achieving Positive Diagnosis in Patients Explored By Capsule Endoscopy Marion Simon*, Florence Gillaizeau, Joel Edery, Thibaut Maniere, Christophe Cellier, Gilles Chatellier, Raymond Jian

M1012

A Randomized Prospective Study for Sequence of SameDay Upper and Lower Endoscopy Without Sedation Jae Hee Cho*, Jie-Hyun Kim, Yong Chan Lee, Won Ho Kim, Jae Bock Chung, Sang Kil Lee

M1013

Predictors of Bowel Preparation Quality in Patients Undergoing Colonoscopy- a Preliminary Analysis Marroon Thabane*, Nita Chauhan, Usha Chauhan, Frances Tse, Salim T. Dahab, Melanie A. Wolfe, David Armstrong

M1014

The Establishment and Clinical Appliance of Technique for Mucosa Marking Targeting Biopsy Leimin Sun*, Jianmin Si

M1015

The Yield of Sigmoideoscopy and Colonoscopy in Patients Referred with Lower Abdominal Symptoms Rannveig Gildberg, Jane M. Hansen*, Jens Kjeldsen

M1016

Appropriateness of Colonoscopy in a Tertiary Care Hospital: An Analysis of Its Magnitude and Associated Risk Factors Lidia Arguello*, Virginia Pertejo, Salvador Peiro, Andrea Nevárez, Vicente Pons, Marta Ponce, Vanesa E. Martinez, Teresa Sala, Julio Ponce, Vicente Garrigues

M1017

The Usefulness of Total Colonoscopy with a Transparent Cap Won Moon*, Seun Ja Park, Jun Young Song, Moo In Park, Kyu Jong Kim

M1018

At What Age Has Your Patient Had a Gut Full of Screening Colonoscopy? Experience from the Screening Colonoscopy in Older People (SCOPE) Study Oyekoya T. Ayonrinde*, Frank M. Sanfilippo

M1018a

The Efficacy of Prefixed Equimolar Nitrous Oxyde and Oxygen Mixture (N2O) for Gastroduodenal Endoscopy Tolerance: A Randomized, Double-Blind Trial, Versus Placebo Brigitte Bernard-Chabert*, Benjamin Papon, Fabien Vitry, Elodie Scaglia, Hedia Brixi-Benmansour, Alexandra Heurgué, Stephanie Lagarde, Fidy Ramaholimihaso, Olivier Bouché, Guillaume Cadiot, Gerard Thiefin

Sails Pavilion San Diego Convention Center

Sponsored by: Clinical Practice

ENDOSCOPY Participants will be able to: • Learn the evidence to support the use of endoscopic techniques. M1000



Increasing Rates of Anesthesiologist Assisted Colonoscopies in Ontario Othman Alharbi*, Linda Rabeneck, Lawrence Paszat, Duminda N. Wijeysundera, Rinku Sutradhar, Lingsong Yun, Christopher M. Vinden, Jill M. Tinmouth

M1001

Pre-Procedure Geriatric Counseling Decreases PEG Placement in Inpatients Arun C. Swaminath*, Eva Runnman, George F. Longstreth

M1002

M1003

M1004

M1005

M O N D A Y MAY 19

Effectiveness of Endoscopic Submucosal Dissection to Resect Large Colonic Polyps: A Meta-Analysis and Systematic Review Srinivas R. Puli*, Yasuo Kakugawa, Takuji Gotoda, Jyotsna BK Reddy, Daphne Antillon, Yutaka Saito, Mainor R. Antillon Diminishing Returns of Sequential Procedural Interventions in Gastroenterology Amnon Sonnenberg Do Patients Know Why They Had a Colonoscopy? Deborah A. Fisher*, Janet Grubber, Cynthia J. Coffman, Corrine I. Voils, Sally W. Vernon, Dawn Provenzale Improved Diagnoses of Corpus Gastric Atrophy: “It's All About Location!” The Sydney System Systematically Underestimates the Presence of Corpus Gastritis: The Baylor System of Hisologic Grading Hala El-Zimaity*, Robert H. Riddell, Suhaib Abudayyeh, Antone R. Opekun, David Y. Graham



M1006



A Quality Initiative Successfully Decreases Pathology Specimen Labeling Errors in a High-Volume Endoscopy Center Shalini Prabhakar*, Dawn L. Francis

M1007



A Prospective Randomized Double-Blind PlaceboControlled Multicenter Trial of Glyceryl Nitrate Preventing Post-ERCP Pancreatitis Camilla Nøjgaard*, Peter Matzen, Kåre E. Bakkevold, Margarita Elkjaer, Truls Hauge, Mads Hornum, Laurent Heyries, Claes Hjalmarsson

M1008



Eosinophilic Esophagitis: Analysis of Food Impaction and Perforation in 251 Adult Patients Alain Schoepfer*, Christian Bussmann, Markus Zuber, Simone Vannini, Hans-Uwe Simon, Alex Straumann

GERD, BARRETT'S ESOPHAGUS, AND ESOPHAGEAL CANCER

M1009

Eradication of Intra-Anal Condylomata Acuminata and Histologically Dysplasia with Combined Intralaesional Cidofovir and Coagulations Georges Coremans*, Jan Wyndaele, Steven Dockx, Freddy G. Vandenbussche, Karel Geboes, Erik De Clercq, Robert Snoeck

M1019

Changing Pattern of Esophageal Cancer Incidence in New Mexico: A 30 Year Evaluation Kenneth J. Vega*, M Mazen Jamal, Charles L. Wiggins

M1020

The Impact of Gastroesophageal Reflux Symptoms On Quality of Life in COPD Patients Ivan E. Rascon-Aguilar, Mark Pamer, James Cury, Kenneth J. Vega*

M1010

P-188

Fibrin Glue Instillation in the Treatment of Complex Anal Fistulas: Results of the First Thirty Patients in a Referral Center Jean David Zeitoun*, Hessam Safa Far, Vincent de Parades, Etienney Isabelle, Nathalie Meary, Benoit Mory, Sultan Samy, Atienza Patrick, Pierre Bauer

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Clinical Practice

Participants will be able to: • Evaluate recent research on GERD, barrett's esophagus, and esophageal cancer.

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL M1021

Thermal Ablation of Barrett's Esophagus: A 6 year Follow-Up Sachin B. Wani*, Richard E. Sampliner, Ajay Bansal, Amit Rastogi, Sharad C. Mathur, April D. Higbee, Lisa Camargo, Krishna Pondugula, Prateek Sharma

M1022

Metabolic Syndrome Is Not a Risk Factor for Barrett's Esophagus Sachin B. Wani*, Krishna Pondugula, Ajay Bansal, Sandy B. Hall, Amit Rastogi, Prateek Sharma

M1023

M1024

M1025

Are Symptom Profiles Different in Reflux Patients with and Without Hiatal Hernia? Sachin B. Wani*, Krishna Pondugula, Sandy B. Hall, April D. Higbee, Ajay Bansal, Amit Rastogi, Prateek Sharma Does the Dosing Frequency of Proton Pump Inhibitors (PPIs) Affect Medication Adherence Among Patients Diagnosed with Gastroesophageal Reflux Disease (GERD)? Luke Boulanger, Reema Mody*, Yanjun Bao, Smita Kothari, Mason W. Russell Reliability, Validity and Responsiveness of the Patient Assessment of Upper Gastrointestinal Disorders Quality of Life (PAGI-QOL) and Symptom Severity Index (PAGI-Sym) in Patients with Erosive Esophagitis (EE) Neesha Harnam, Misun Lee, Reema Mody*, Lois M. Larsen, Dennis A. Revicki, Kathleen W. Wyrwich

M1026

Antisecretory Agents Impair Drugs Absorption: A Systematic Review Edith Lahner, Bruno Annibale, Gianfranco Delle Fave*

M1027



Psychological Well-Being and Quality of Life (QOL) in Barrett's Esophagus (BE) Compared to Gastroesophageal Reflux Disease (GERD) Quinn K. Lippmann*, Ryan D. Madanick, Melissa Spacek, Paris . Heidt, Douglas R. Morgan, Stephanie D. Bright, Catherine Zimmer, Nicholas J. Shaheen

M1028

Development and Validation of a Disease-Specific Quality of Life (QOL) Questionnaire for Gastroesophageal Reflux Disease (GERD): GERD-QOL Questionnaire Yawen Chan*, Jessica Ching, Carrian Cheung, Kelvin K. Tsoi, Francis K. L. Chan, Joseph J. Sung, Justin Wu

M1029

M1030

M1031

M1032

Gender Difference in Symptomatology and Quality of Life (QOL) of Patients with Non-Erosive Reflux Disease (NERD) Yawen Chan*, Kelvin K. Tsoi, Jessica Ching, Carrian Cheung, Francis K. L. Chan, Joseph J. Sung, Justin Wu Impact of Barrett's Esophagus Containing Dysplasia On Patient Quality of Life: Interim Results of a Randomized, Sham-Controlled Trial of Radiofrequency Ablation (AIM Dysplasia Trial) Nicholas J. Shaheen*, Herbert C. Wolfsen, Robert H. Hawes, Richard I. Rothstein, Stuart J. Spechler, Joseph Galanko, Stephanie D. Bright, Anthony Infantolino, Ali Siddiqui Factors Contributing in Response of Patients with Gastroesophageal Reflux Disease to PPI Therapy Siavosh Nasseri-Moghaddam*, Hadi Razjouyan, Mansoureh Mamarabadi, Seyed-Maysam Alimohamadi, Azadeh Mofid, Shiva Ostad-Rahimi, Reza Malekzadeh Interactions of GERD-Related Symptoms, Health-Related Quality of Life and Anxiety and Depression in GERD Patients Treated with a PPI Robert Heading*, Peter Berghoefer, Hubert Doerfler, Holger Schmitt, Hubert Monnikes

M1033

Nighttime Symptoms and Sleep Impairment Among Patients with Gastro-Esophageal Reflux Disease (GERD) Receiving Prescription (Rx) Proton Pump Inhibitors (PPIs) William D. Chey*, Reema Mody, Lei Chen, Smita Kothari, Bjorn Persson, Eric Wu, Mei Lu

M1034

Incidence of Gastroesophageal Reflux Symptoms and Remission Rate in General Population Enrique Rey*, Fernando Rodriguez Artalejo, Angel Alvarez Sanchez, Manuel Diaz-Rubio

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Clinical Practice

GI EPIDEMIOLOGY Participants will be able to: • Evaluate recent research on GI epidemiology. M1035

Fluctuation of Gastrointestinal Symptoms in the Community: A 10-Year Longitudinal Survey Alexander C. Ford*, Alastair G. Bailey, David Forman, Anthony Axon, Paul Moayyedi

M1036

Systematic Review and Meta-Analysis of the Saftey of Bismuth Alexander C. Ford*, Mostafizur Khan, Jose O. Santana, Monique Giguere, Paul Moayyedi

M1037

Pancreatic Mucinous Cystadenocarcinoma Incidence in the US Population James L. Lin*, Bashar M. Attar

M1038

Prevalence of Celiac Disease in a Community Hospital Health Maintenance Organization Carolina Begue, Juan A. De Paula*, Emilio Varela, Héctor L. Piccioni, Berratarrechea Andrea, Adriana R. Dawidowski, Liliana Rodota, Maria E. Castro, María F. Koll, Esteban R. Langlois, Marcelo Marchetti, Jorge R. Davolos

M1039

Incidence of Diarrheal Diseases and Micro Nutrtients Intervention and Their Relationship with the Nutritional Status, in Different Birth Weight Babies, a Study from India Harish Payal*, Subash C. Arya, Neera Arya, Saurabh K. Gupta, Megha Shandilya

M1040



Adherence to “Best Practices” in Dyspepsia Management: A National Vignette Survey of Internists, Nurse Practitioners, Community Gastroenterologists and Experts Brennan M. Spiegel*, Mary Farid, Martijn G. van Oijen, Loren A. Laine, Colin W. Howden, Eric Esrailian

M1041

Are Proton Pump Inhibitors (PPIs) Sufficient in Controlling Symptoms of Gastro-Esophageal Reflux Disease (GERD)?: A Community-Based US Survey Study William D. Chey*, Reema Mody, Smita Kothari, Eric Wu, Lei Chen, Bjorn Persson, Nicolas Beaulieu, Mei Lu

M1042

The Quality of Open Access and Open Source Internet Material in Gastroenterology: Is Wikipedia Appropriate for Knowledge Transfer to Patients? Kasia Czarnecka-Kujawa, Rupert Abdalian, Samir C. Grover*

M1043

Combined Faecal and Urinary Incontinence in Patients Attending a University Gastroenterological or Urological Clinic Michel Wyndaele*, Benedicte Y. De Winter, Stefan De Wachter, Marc J. Van Outryve, Jean-Jacques Wyndaele, Paul A. Pelckmans

Denotes DDW Poster of Distinction

P-189

M O N D A Y MAY 19

POSTER SESSIONS—CLINICAL M1044



Factorial Structure, Validity and Internal Consistency of the Multi-Dimensional Gastrointestinal Symptoms Severity Index (GISSI) Stephanie L. Hansel*, Sarah Umar, Lucinda A. Harris, John K. DiBaise, Michael P. Jones, Michael D. Crowell

M1045

What Factors Predict Response to Therapy for Those with Abdominal Wall Pain Brian Rajca, Joshua Wellington, George J. Eckert, Paul Kwo*

M1046

How Do We Interpret An Elevated Carbohydrate Antigen 19-9 Level in Asymptomatic Subjects? Beom Jin Kim*, Kyu Taek Lee, Tae Gun Moon, Pung Kang, Soo Yeong Kwak, Jong Kyun Lee, Seung Woon Paik, Jong Chul Rhee, Yoon Ho Choi

M1047

Validation of the Digestive Comfort Questionnaire and Relationship with Diet and Stress Amongst UK Students: A Cross-Sectional Study Alison Woodcock*, Blandine Stefani, Jessica Jackson, Stacey Marshall, Aleksandra Skalimowska, Denis Guyonnet

M1048

Quality of Life in Short Bowel Syndrome: The Impact of Fatigue and Gastrointestinal Symptoms Evangelos Kalaitzakis*, Eva Carlsson, Axel Josefsson, Ingvar Bosaeus

M1049

Low Response Rate for FOLFOX4 in Patients Who Developed Recurrence After Completion of Adjuvant Chemotherapy By Uft/Leucovorin or 5-Fluorouracil/ Leucovorin Takafumi Maeda*, Yutaka Kawamura, Fumio Konishi

M1050

M1051

M1052

M O N D A Y

Bowel Dysfunction in Spinal Cord Injury Correlates with Inpatient Utilization and Survival William Berger*, Kevin T. White, Paula S. Benes, Barbara A. Walsh, James Hastings, Joseph E. Berman, Rizwana Sultana, Raymond G. Hoffmann, Mary F. Otterson Gastroenterologists' Experience with the Physicians Quality Reporting Initiative (PQRI): A Demonstration Project Brian C. Jacobson*, Sheila Madhani, Colleen M. Schmitt Short-Term Faecal Incontinence After 3rd/4th Degree Tear Is Uncommon Kumaran Thiruppathy*, Richard Cohen, Stuart A. Taylor, Adeel A. Bajwa, Anton V. Emmanuel

M1053

Bone Health Quality Improvement in a Tertiary GI/ Hepatology Clinic Millie Long*, Lisa M. Gangarosa, Robert Sandler

M1054

Impact of Anal Incontinence Severity On Functional Status Measured By the Fecal Incontinence Quality of Life Scale (FIQOL) Sailajah Janarthanan*, Stephanie L. Hansel, Sarah Umar, Lucinda A. Harris, Tisha N. Lunsford, Michael P. Jones, Michael D. Crowell

MAY 19 M1055

Short Bowel Patients Treated for Two Years with Native Glucagon-Like Peptide 2 (GLP-2): Compliance, Safety and Effects On Quality of Life Palle B. Jeppesen*, Ida B. Gottschalck, Jens J. Holst, Per B. Mortensen

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

H. PYLORI: DIAGNOSIS Participants will be able to: • Evaluate recent research regarding diagnosis of Helicobacter pylori. M1056

Peptic Ulcer Disease: What Did Change in Turkey? Askin Yazici, Filiz Akyuz*, Halim Issever, Binnur Pinarbasi, Kadir Demir, Sadakat Ozdil, Fatih Besisik, Gungor Boztas, Zeynel A. Mungan, Sabahattin Kaymakoglu

M1057

1 Minute Urea Ultrafast-Test for Helicobacter pylori (H. pylori) Diagnosis Federico Perna*, Ilaria M. Saracino, Chiara Ricci, Dino Vaira

M1058

Helicobacter pylori Recurrence in Developed and Developing Countries: Meta-Analysis of 13c-Urea Breath Test Follow-Up After Eradication Yaron Niv*, Rachel Hazazi

M1059

Helicobacter pylori Infection Not Diagnosed At Endoscopy: Long-Term Outcomes Stephen J. Sontag*, Kapil Mehta, Thomas G. Schnell, Jack Leya, GI Fellows Hines-Loyola

M1060

Rapid and Superior Diagnosis of H. pylori Infection By C-Urea HeliprobeTM Test Versus the PYtest® Thomas J. Borody*, Antony R. Wettstein, Jordana Campbell, Margaux Torres, Lauren A. Hills, Kylie J. Herdman, Gerald Pang, Sanjay Ramrakha 14

M1061

Does Helicobacter pylori Infection Impact On Life Expectancy? Nathalie Salles*, Alexandre Jehanno, Alice Buissonniere, Luc Letenneur, Jean François Dartigues, Francis Megraud

M1062

Helicobacter pylori Infection Is Not Associated with Iron Deficiency in Adults Nilesh Mehta*, Bridgit James, Nicole Edison, Juan Diego Baltodano, Vivek Kaul, Uma K. Murthy

M1063

Immunohistochemical Confirmation of the Causitive Role of Helicobacter pylori in Severe Gastritis in Children John Snyder*, Jeannette Guarner, Yunn-Yi Chen, Benjamin D. Gold, Steven Czinn

M1064

Evaluation of a Rapid 14C Desktop Analyzer for Diagnosis of Helicobacter pylori Infection David J. Kearney*, Janelle V. Brown-Chang

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

H. PYLORI: TREATMENT AND ANTIMICROBIAL RESISTANCE Participants will be able to: • Review research about the treatment and antimicrobial resistance patterns of Helicobacter pylori. M1065



P-190

Sequential Regimens Have Greater Efficacy and Better Tolerability Than Standard Triple Therapy in the Eradication of Helicobacter pylori Infection Omero Alessandro Paoluzi*, Emanuela Visconti, Fabio Andrei, Claudio Tosti, Mario Erboso, Raffaella T. Lionetti, Enrico Grasso, Riccardo Ranaldi, Italo Stroppa, Francesco Pallone

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL M1066



Second-Line Treatment for Helicobacter pylori Infection: 10-Day Moxifloxacin-Based Triple Therapy vs. 2-Week Quadruple Therapy Jung Mook Kang*, Nayoung Kim, Dong Ho Lee, Young Su Park, Yu Rim Kim, Joo Sung Kim, Hyun Chae Jung, In Sung Song

M1067



In Vitro Activityies of Levofloxacin and Seven Other Fluorquinolones Against Clinical Isolates of Helicobacter pylori with or Without gryA Mutations; What Regimen Is a Promising Eradication Therapy in the Next Generation? Hideyuki Miyachi*, Ikuya Miki, Daisuke Shirasaka, Yuko Matsumoto, Shigeto Mizuno, Takeshi Azuma, Masato Kasuga

M1068

The Degree and Duration of Acid Suppression During Treatment Is Related to Helicobacter pylori Eradication By Triple Therapy Mitsushige Sugimoto*, Takahisa Furuta, Chise Kodaira, Masafumi Nishino, Mihoko Yamade, Mutsuhiro Ikuma, Akira Hishida



M1069

M1070

M1071

M1072

Helicobacter pylori Eradication: A Randomized Prospective Study of Triple Therapy Versus Triple Therapy Plus Ecabet Sodium Gwang Ha Kim*, Hyung Wook Kim, Jong Yun Cheong, Seung Keun Park, Chul Soo Song, Chan Ho Park, Kyung Yeob Kim, Dae Hwan Kang, Geun-Am Song, Ung Suk Yang 7-Day Retreatment with Furazolidone, Levofloxacin and Lansoprazole for the Eradication of Helicobacter pylori in Sao Paulo, Brazil Jaime N. Eisig*, Fernando M. Silva, Ricardo C. Barbuti, Tomas Navarro-Rodriguez, Schlioma Zaterka, Joaquim P. Moraes-Filho Mechanisms of Aspirin Increasing the Susceptibility of Helicobacter pylori to Antimicrobials Xiaoping Zhang, Weihong Wang*, Yu Tian, Wen Gao A Novel Bactericidal Strategy for Helicobacter pylori Based On Alteration of Its TCA Cycle Enzymatic Activity Which Determines the Helical or a Coccoid Form of Existence of This Bacterium Hitoshi Tsugawa*, Hidekazu Suzuki, Izumi Nakagawa, Toshihiro Nishizawa, Yoshimasa Saito, Makoto Suematsu, Toshifumi Hibi

M1073

Fourth-Line Rescue Therapy in Patients with Three H. pylori Eradication Failures Javier P. Gisbert*, Manuel Castro-Fernandez, Eloisa Lamas, Angeles Perez-Aisa, Jose Luis Cabriada, Luis Rodrigo, Luis Miguel Benito, Jose Luis Gisbert, Eusebio Marcos

M1074

Third-Line Levofloxacin-Based Rescue Regimen in Patients with Two H. pylori Eradication Failures: A Spanish Multicenter Study Javier P. Gisbert

M1075

M1076

M1077

Second-Line Rescue Therapy with Levofloxacin After H. pylori Treatment Failure: A Spanish Multicenter Study Javier P. Gisbert Helicobacter pylori First-Line Treatment and Rescue Option in Patients Allergic to Penicillin Javier P. Gisbert*, Manuel Castro-Fernandez, Angeles PerezAisa, Luis Rodrigo, Jesus Barrio, Jose Luis Gisbert, Eusebio Marcos The Efficacy of Adding Sofalcone to One-Week, LowDose Triple Therapy for Helicobacter pylori Eradication in Patients with Chronic Gastritis Taek Man Nam*, Dong Ho Lee, Nayoung Kim, Sook Hyang Jeong, Jin Wook Kim, Jin Hyeok Hwang, Young Soo Park, Sang Hyub Lee, Hyun Chae Jung, In Sung Song

M1078

Clinical Factors Potentially Influencing Eradication of Helicobacter pylori in Peptic Ulcer in Korea: Age Over 60 and Gastric Ulcer Were Associated with Lower Eradication Rate Taek Man Nam*, Dong Ho Lee, Nayoung Kim, Sook Hyang Jeong, Jin Wook Kim, Jin Hyeok Hwang, Young Soo Park, Sang Hyub Lee, Hyun Chae Jung, In Sung Song

M1079

Histological Factors That Affect Treatment Outcome of Helicobacter pylori Eradication in Peptic Ulcers in Korea: High Grade of Gastric Atrophy Was Associated with Low Eradication Rate Taek Man Nam*, Dong Ho Lee, Nayoung Kim, Sook Hyang Jeong, Jin Wook Kim, Jin Hyeok Hwang, Young Soo Park, Sang Hyub Lee, Hyun Chae Jung, In Sung Song

M1080

Tremella Mesenterium (Yellow Brain Mushroom) 10-Day Therapy Is Not Effective for Eradication of Helicobacter pylori; a Prospective Controlled Trial Jesse Lachter*, Yevgeny Yampolsky, Rami Eliakim

M1081

Glutamate Supplementation Protects Helicobacter pyloriInduced Gastric Mucosal Damages in Gerbils Eiji Nakamura*, Kikuko Amagase, Mai Hasumura, Ana San Gabriel, Hisayuki Uneyama, Kunio Torii, Koji Takeuchi

M1082

Fluoroquinolone Resistance Rate and Resistance Mechanism in Helicobacter pylori Strains from Korean Patients Jae G. Kim*, Su Yeon Rhie, Ki Sung Kim, Bum Joon Park, Jeong Wook Kim, Sill Moo Park

M1083

Clinical Role of gryA Mutations in 7- and 10-Day PPILevofloxacin-Amoxicillin Regimens for Refractory Helicobacter pylori Infection to Standard Therapy Ikuya Miki*, Hideyuki Miyachi, Yuko Matsumoto, Yoshinori Morita, Masaru Yoshida, Takao Tamura, Takashi Toyonaga, Hiromu Kutsumi, Hideto Inokuchi, Shigeto Mizuno, Takeshi Azuma

M1084

A Strategy for the Penicillin Allergic Patient Requiring Treatment for Helicobacter pylori Avelyn Kwok*, Ronald Walls, Peter H. Katelaris

M1085

Bovine Antibodies-Based Oral Immunotherapy for Reduction of Intragastric Helicobacter pylori Bacterial Load: A Randomized Placebo-Controlled Clinical Trial Annemarie C. de Vries*, Peter B. Mensink, Cindy Dierikx, Herman van Dekken, Ernst J. Kuipers

M1086

Non-Sequential Quadruple Therapy As a Forgotten Alternative for Helicobacter pylori Eradication - a Systematic Review of Available Data Gerhard Treiber

M1087

H. pylori Isolates from Proximal and Distal Stomach of Patients with H. pylori Infection Exhibit Resistance and Sensitivity to the Same Antibiotic Maria Amitrano, Mariangela Spezzaferro, Flora Sacco, Mariaelena Serio, Brunella Cerasa, Laurino Grossi, Leonardo Marzio*

M1088

Rapid Molecular Assay for the Diagnosis of Clarithromycin Resistant Helicobacter pylori Directly from Human Gastric Biopsies-An Approach to Design Antibiotic Regimen Chittor M. Habibullah*, Santosh K. Tiwari, Md. Aejaz Habeeb, Manoj Gopi, Shakeel Ahmed, Aleem A. Khan

M1089

Risks of Failure in Helicobacter pylori Eradication By Lansoprazole, Amoxicillin, and Metronidazole Triple Therapy in Japan Keiji Ogura*, Yuzo Mitsuno, Shin Maeda, Yoshihiro Hirata, Ayako Yanai, Masao Akanuma, Yutaka Yamaji, Makoto Okamoto, Haruhiko Yoshida, Takao Kawabe, Masao Omata

Denotes DDW Poster of Distinction

P-191

M O N D A Y MAY 19

POSTER SESSIONS—CLINICAL M1090

Rifabutin Resistance of H. pylori Isolated from Japanese Patients Shoji Suzuki*, Hidekazu Suzuki, Toshihiro Nshizawa, Fumihiko Kaneko, Yoshimasa Saito, Sumire Ootani, Hiroe Muraoka, Intetsu Kobayashi, Mamoru Miyairi, Toshifumi Hibi

M1091

Ten-Day Sequential Therapy Is Superior to Triple Therapy for the Eradication of Helicobacter pylori: Systematic Review and Meta-Analysis Luigi Gatta, Dino Vaira, Nimish Vakil*

M1092

A Randomized Double Blinded Clinical Trial with Omeprazole, Levofloxacin and Escalated Dose of Rifaximin for Helicobacter pylori in Treatment-Naïve Population P. Patrick Basu*, Krishna Rayapudi, Jose Estevez

M1093

Levofloxacin- and Amoxcillin-Based Quadruple Therapy for the Third-Line Treatment of Helicobacter pylori Infection Ping-I Hsu*, Deng-Chyang Wu

M1094

Increased Prevalence of Helicobacter pylori 23s rRNA Gene Mutations in Patients with Gastritis in Pakistan Javed Yakoob*, Wasim Jafri, Zaigham Abbas, Shahab Abid, Rustam Khan, Nida Jafri, Zubair Ahmad

M1095

M1096

M1097

M O N D A Y MAY 19

Empirical Rescue Therapy After H. pylori Treatment Failure: A 10-Year Single Center Study of 500 Patients Javier P. Gisbert*, Jose-Luis Gisbert, Eusebio Marcos, Isabel Jimenez-Alonso, Adrian G. McNicholl, Ricardo MorenoOtero, Jose-Maria Pajares High Dose vs. Standard Dose Proton Pump Inhibitor Triple Therapy for Helicobacter pylori Eradication: A Meta-Analysis Albert Villoria*, Xavier Calvet, Pilar Garcia, Javier P. Gisbert, Valentí Puig Diví Reflux Symptoms Worsen After Eradication of Helicobacter pylori in Japanese Patients with Atrophic Gastritis Haruka Kajiwara*, Yutaka Yamaji, Noriyuki Takano, Takafumi Sugimoto, Atsuo Yamada, Masao Akanuma, Goichi Togo, Keiji Ogura, Makoto Okamoto, Haruhiko Yoshida, Takao Kawabe, Masao Omata

AGA Institute Poster Session 8:00 AM - 5:00 PM

M1100

Increased Prevalence of Gastroesophageal Reflux Disease (GERD) in Hospitalized U.S. Children: A Growing Healthcare Problem Tejas R. Mehta*, Troy Gibbons, Jana Stockwell, Traci Leong, William S. McRae, Gayle D. Horvitz, Benjamin D. Gold

M1101

Prevalence of Night-Time Reflux in Children Is An Age Related Phenomenon Alex Koral, P. Christine Nguyen, James P. Marcin, J. Antonio Quiros*

M1102

Aldohexose Malabsorption in Preterm Pigs Is Directly Related to the Severity of Necrotizing Enterocolitis Randal K. Buddington*, Stine B. Bering, Thomas Thymann, Per T. Sangild

M1103

Risk Factors for the Development of Parenteral Nutrition Associated Liver Disease in a Cohort of Surgical Patients with Necrotizing Enterocolitis: A Multicenter, Prospective Cohort Study Debora Duro*, Tom Jaksic, Paul D. Mitchell, Leslie A. Kalish, Maggie McCarthy, James Dunn, Mary L. Brandt, Karl Sylvester, Kerilyn Nobuhara, R. L. Moss, Christopher Duggan

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sponsored by: Imaging & Advanced Technology

WIRELESS CAPSULE/TRANSABDOMINAL U.S. Participants will be able to: • Review wireless capsule and transabdominal U.S. research. M1104



The First Clinical Experience of Capsule Endoscope “MiroCam” Using a Novel Transmission Technolongy and a Prospective Trial to Diagnose Radiation Enteritis in Patients Receiving Chemoradiotherapy for Pancreatic Cancer Hee Man Kim*, Jeong Youp Park, Jin Sook Jang, Jae Hee Cheon, Sang Kil Lee, Seungmin Bang, Seung Woo Park, Si Young Song

M1105

Performance Characteristics of Suspected Blood Indicator Feature in Capsule Endoscopy According to Indication for Study Jonathan M. Buscaglia*, Samuel A. Giday, Sergey V. Kantsevoy, John O. Clarke, Priscilla Magno, Elaine Yong, Gerard E. Mullin

M1106

The Role of Wireless Capsule Endoscopy in Suspected Celiac Disease Patients with Positive Celiac Antibodies Ilmars Lidums*, Adrian G. Cummins, Edward Teo

M1107

Small Bowel Purge After the Entrance of the Capsule in the Duodenum Results to Better Quality of Bowel Preparation for Video-Capsule Endoscopy. Prospective, Randomized, Double-Blind, Placebo-Controlled, Real Time Viewer Assisted Study Konstantinos Triantafyllou*, Theodora Kalli, Spiros D. Ladas

M1108

Capsule Endoscopy Is Useful and Safe for Small Bowel Surveillance in Familial Adenomatous Polyposis Gaetano Iaquinto*, Mara Fornasarig, Michele Quaia, Nicola Giardullo, Vittorio D'onofrio, Salvatore Iaquinto, Simone Di Bella, Renato Cannizzaro

M1109

The Clinical Impact of Esophageal Capsule Endoscopy for Screening of Esophageal Varices in Cirrhotic Patients Haruya Ishiguro*, Shoichi Saito, Hiroo Imazu, Hiroyuki Aihara, Hisao Tajiri

Sails Pavilion San Diego Convention Center

Sponsored by: Growth, Development & Aging

CLINICAL PEDIATRIC GASTROENTEROLOGY: ESOPHAGEAL AND INTESTINAL DISORDERS Participants will be able to: • Learn about emerging esophageal and intestinal disorders in clinical pediatric gastroenterology. M1098

M1099

P-192

Increased Rates of Peptic Ulcer Disease (PUD) and Helicobacter pylori (HP) Related Hospitalizations in U.S. Children: A 15 Year Analysis Gayle D. Horvitz*, William S. McRae, Sarah Talarico, Tejas R. Mehta, Nina R. Salama, Jana Stockwell, Malinda Kennedy, Benjamin D. Gold Symptom Association During Impedance Testing (pHMII) Is Not Useful in Predicting Outcome After Fundoplication Rachel Rosen*, Phillip Levine, Paul D. Mitchell, Samuel Nurko

Sails Pavilion San Diego Convention Center

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL M1110

Influence of Simeticone and Metoclopramide Administration for Capsule Endoscopy Preparation:Preliminary Results Begona Gonzalez Suarez*, Ines Ibañez, Luis Barranco, Agustin Seoane-Urgorri, David Monfort, Xavier Bessa, Silvia Delgado-Aros, Beatriz Gras, Lucía Marquez, Nuria Cañete, Montserrat Andreu, Felipe Bory

M1111

Initial Diagnostic Yield of Wireless Capsule Endoscopy in a Randomized Controlled Trial of Wireless Capsule Endoscopy Versus Standard Care for Obscure-Overt Gastrointestinal Bleeding Steven J. Heitman*, Braden J. Manns, Darlene Pontifex, Noel B. Hershfield, Gilaad G. Kaplan, Robert J. Hilsden

M1112



Validation of 3D Ultrasonography to Measure Gastric Emptying of a High-Nutrient Drink in Diabetic Gastroparesis Julie E. Stevens*, Odd Helge Gilja, Diana Gentilcore, Michael Horowitz, Trygve Hausken, Karen L. Jones

M1113

Real-Time Analysis of the Hepatic Vein Arrival Times of Ultrasound Contrast Agents Reveals Hepatic Hemodynamic Changes Induced By the Treatment of Gastric Varices Yoshihiro Furuichi*, Shigeki Ichimura, Ryou Metoki, Jyunichi Taira, Katsutoshi Sugimoto, Masahiko Yamada, Yasuharu Imai, Ikuo Nakamura, Fuminori Moriyasu

M1114

M1115

M1116

Evaluation of Gastric Mucosal Blood Flow Using Contrast-Enhanced Ultrasonography During Low-Dose Aspirin Therapy and During NSAID and Low-Dose Aspirin Combined Therapy Go Kamada*, Mototsugu Kato, Masahiro Asaka, Mutsumi Nishida, Yuichi Shimizu, Manabu Nakagawa, Shouko Ono, Soichi Nakagawa, Jojo Hirota, Takehiko Katsurada, Tamotsu Hata Diagnosis of Pancreatic Carcinoma: Comparison of Contrast-Enhanced Ultrasound and CT Juergen Bauditz*, Antje Bodamer, Juliane Dammenhayn, Herbert Lochs, Wolfram Wermke Contrast-Enhanced Wideband Harmonic Imaging Ultrasound and Contrast Media “Blood-Pool”: Quantitative Measurement of Inflammatory Activity in Crohn's Disease Using Parametric Imaging Luisa Guidi*, Antonio De Franco, Alessandro Armuzzi, Alessandra Di Veronica, Italo De Vitis, Alfredo Papa, Italia Roberto, Manuela Marzo, Barbara De Pascalis, Giovanni Battista Gasbarrini, Giuseppe Fedeli

M1117



Accuracy of Endoscopic Ultrasound in Diagnosing Various T-Stages of Rectal Cancers: A Meta-Analysis and Systematic Review Srinivas R. Puli*, Jyotsna BK Reddy, Matthew L. Bechtold, Praveen K. Roy, Jack D. Bragg, Priya D. Ravindran, Jamal A. Ibdah, Mainor R. Antillon

M1118

Nodal Staging Accuracy of Endoscopic Ultrasound in Gastric Cardia Cancers: A Meta-Analysis and Systematic Review Srinivas R. Puli*, Jyotsna BK Reddy, Matthew L. Bechtold, Mainor R. Antillon, Jamal A. Ibdah

M1119

Assessment of EUS Trucut Biopsy Specimen Adequacy in the Evaluation of Hepatic Parenchymal Disease Ferga C. Gleeson*, Amy C. Clayton, Lizhi Zhang, Jonathan E. Clain, Gregory J. Gores, Elizabeth Rajan, Mark D. Topazian, Kenneth K. Wang, Maurits J. Wiersema, Michael J. Levy

M1120

Accuracy of Endoscopic Ultrasound-Guided Fine Needle Aspiration (EUS-FNA) for the Cytological Diagnosis of Mediastinal Lymph Nodes and Clinical Impact of OnSite Cytophatological Evaluation Jose Larino-Noia, Julio Iglesias-Garcia*, Elena Eugenyeva, José Mera, Ihab Abdulkader, Antonio Lozano-Leon, Susana Seijo-Rios, Begoña Vieites, Jeronimo Forteza, Enrique Dominguez-Munoz

M1121

Is Muscle Thickness a Good Surrogate for Muscle Cross Sectional Area As a Parameter of Longitudinal Muscle Contraction? Arash Babaei*, Luiz J. Abrahao, Ravinder K. Mittal, Valmik Bhargava

M1122

Usefulness of New Ultrasonography Techniques Using a Second Generation Contrast Agent in Biliary and Pancreatic Diseases Atsushi Sofuni*, Takao Itoi, Fumihide Itokawa, Toshio Kurihara, Syujirou Tsuji, Kentarou Ishii, Nobuhito Ikeuchi, Fuminori Moriyasu

M1123

The Accuracy and Safety of Esophageal Capsule Endoscopy for the Detection of Esophageal Varices: A Meta-Analysis Dimple Raina*, Thad Wilkins, Sherman Chamberlain, Mark Ebell

M1124

Gastric Emptying (GE) Can Be Estimated Using BRAVO® Radiotelemetry pH Capsules: Preliminary Data from Healthy Subjects Jason Bratten, Monika A. Kwiatek, John E. Pandolfino, Michael P. Jones*

M1125

Characterization with PillCam ESO of Esophageal Injury After Radiofrequency Ablation Therapy for Atrial Fibrillation Alan Siu*, Milan Dodig, Jan Santisi, Stacy M. Poe, Walid Saliba

M1126

Capsule Endoscopy for Screening of Esophageal Varices: A Cost-Effectiveness Analysis Ma Somsouk*, Ian M. Gralnek, Uri Ladabaum, John M. Inadomi

M1127

A Standardized Bowel Preparation Regime Can Improve Completion Rates and Quality of Study in Capsule Endoscopy Jonathan C. Macdonald, Victoria Porter*, Deirdre McNamara

M1128

Prospective Study to Detect Metastases of the Liver By Using Contrast Enhanced Ultrasound: Comparison with Multi-Detector Row Computed Tomography and Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging Kazuyoshi Nakamura*, Taketo Yamaguchi, Taro Hara, Kentaro Sudo, Tadamichi Denda, Hideyuki Takano

AGA Institute Poster Session 8:00 AM - 5:00 PM

MAY 19 Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

COMPLICATIONS AND OUTCOMES I Participants will be able to: • Learn more about complications and outcomes. M1129

Primary Sclerosing Cholangitis Is Associated with Endoscopic and Histologic Backwash Ileitis in Patients with Ileal Pouch-Anal Anastomosis Katherine Freeman*, Ana E. Bennett, Bo Shen, Rocio Lopez

Denotes DDW Poster of Distinction

M O N D A Y

P-193

POSTER SESSIONS—CLINICAL M1130

The Effects of Azathioprine or 6-Mercaptopurine On Birth Outcome in Women with Inflammatory Bowel Disease Lisa S. Shim*, Alexander A. Simring, Henry Murray, Guy D. Eslick, Martin D. Weltman

M1131

Frequency of Lymphoma in Patients with Inflammatory Bowel Disease (IBD) in An Academic Center David Kotlyar*, Wojciech Blonski, Mark Weiner, James D. Lewis, Gary R. Lichtenstein

M1132

Frequency of Osteonecrosis in Patients with Inflammatory Bowel Disease: A Cohort Analysis David Kotlyar*, Wojciech Blonski, Mark Weiner, James D. Lewis, Gary R. Lichtenstein

M1133

Experts and Community Providers Have Varying Beliefs About the Appropriateness of Colectomy for Flat Low Grade Dysplasia (LGD) in Ulcerative Colitis (UC) Brennan M. Spiegel*, Wayne Ho, Eric Esrailian, Gil Y. Melmed, Peter D. Higgins, Corey A. Siegel, Marla C. Dubinsky, Stephan R. Targan

M1134

M1135

M1136

M1137

M O N D A Y

M1138

Newly Diagnosed Neoplasia in a Cohort of Crohn's Disease Patients Treated with Infliximab: A 3 Years Longer Follow Up from a Multicenter Matched-Pair Study Livia Biancone*, Ambrogio Orlando, Anna Kohn, Sandro Ardizzone, Marco Daperno, Erika Angelucci, Fabiana Castiglione, Renata D'Incà, Claudio Papi, Fernando Rizzello, Gianmichele Meucci, Gabriele Riegler, Carmelina Petruzziello, Filippo Mocciaro, Sara Onali, Emma Calabrese, Mario Cottone, Francesco Pallone When Should Ulcerative Colitis Patients Undergo Colectomy for Dysplasia? Mismatch Between Patient Preferences and Physician Recommendations Corey A. Siegel*, Lisa M. Schwartz, Steven Woloshin, Elisabeth B. Cole, David T. Rubin, Alana P. Bunnag, Tegan Vay, Judith E. Baars, Bruce E. Sands The Natural History of Dysplasia in Inflammatory Bowel Disease: Influence of Disease Type and Dysplasia Morphology and Grade On Cancer Risk Thomas A. Ullman*, Daniel Wild, Seamus J. Murphy, Adam S. Cheifetz, Miles Sparrow, Daniel H. Present The Natural History of Infusion Reactions in Infliximab Recipients Nielsen Q. Fernandez-Becker*, Kyung Jo Kim, Didia B. Cury, Adam S. Cheifetz, Alan C. Moss Serious Events During Nine Years Single Center Experience with Infliximab Hilbert S. de Vries*, Martijn G. van Oijen, Dirk J. De Jong

M1139

Nationwide Referral Patterns to Specialized Medical Centers for the Inpatient Management of Inflammatory Bowel Disease Geoffrey C. Nguyen*, A. Hillary Steinhart

M1140

Low Surgery Rates After Diagnosis of Colorectal Dysplasia in Ulcerative Colitis: An Opportunity for Intervention? Fernando S. Velayos*, Liyan Liu, Bernie Collins, James E. Allison, Jonathan P. Terdiman, Lisa J. Herrinton

M1141

Infliximab Maintenance Therapy Decreases the Use of Non-Pharmacological Resources in Patients with Crohn's Disease Carlos Taxonera*, Luis Rodrigo, Francesc Casellas, Xavier Calvet, Federico Gómez-Camacho, Daniel Ginard, Manuel Castro-Fernandez, Luisa Castro, Marta Ponce, Pilar Martínez, Elena Ricart, Javier P. Gisbert, Antonio López-San Román, José M. Morales, Miguel A. Casado

MAY 19

P-194

M1142

Clinical Course of Crohn's Disease Following Lymphoma Treatment Nicholas Sun*, Jeffry A. Katz, Mazen Issa, Joshua F. Knox, Susan Skaros, Mary F. Otterson, David G. Binion

M1143

Benefits of Dosage Adjustment with Adalimumab in Crohn's Disease: An Analysis of the CHARM Trial William J. Sandborn*, Jean-Frédéric Colombel, Paul Rutgeerts, Paul F. Pollack, Jingdong Chao, Parvez Mulani

M1144

Extra-Intestinal Manifestations As Predictors of Colorectal Cancer in Ulcerative Colitis Ihab Hammoud*, Gourisankar Degala, Ramy Fayad, Osama H. Alaradi

M1145

Surveillance Colonoscopy and Biopsy Underestimates Dysplasia/Cancer in Ulcerative Colitis (UC) Patients Undergoing Colectomy Arslan Kahloon*, Wolfgang H. Schraut, Miguel Regueiro

M1146

Long-Term Outcome and Adverse Events in Crohn's Disease Patients Treated with Infliximab At a Single Tertiary Referral Center Over 9 Years Andrew N. Milestone*, Dominic C. Bullas, Ailsa L. Hart, Michael A. Kamm, Naila Arebi

M1147

Development of a Claims-Based Markov Model for Crohn's Disease Daniel C. Malone*, Heidi C. Waters, Jill Van Den bos, John Popp, Ksenia Draaghtel, Mirza I. Rahman

M1148

The Risk of Colorectal Carcinoma in IBD Patients Is Limited in Non-Tertiary Cohorts: Results of a Nation Wide Long-Term Survey Judith E. Baars*, E. J. Kuipers, Rob Adang, Leopold G. Engels, Gezina W. Erkelens, Jan J. Nicolaï, M. K. Casparie, Christien J. van der Woude

M1149

Genetic Markers and the Risk of Complicated Disease Behaviour in Crohn's Disease Patients Liesbet Henckaerts, Isabelle Cleynen*, Marie Joossens, Kristel Van Steen, Karolien Claes, Paul Rutgeerts, Séverine Vermeire

M1150

Predictors of Steroid-Dependent/Refractory Inflammatory Bowel Disease Dorothy K. Chow*, Justin Wu, Larry H Lai, Grace Wong, Wai K. Leung, Francis K. L. Chan, Joseph J. Sung

M1151

Outcomes After Ileal Resection in Paediatric Crohn Disease: A 30 Year Single Center Experience Thomas D. Walters*, Alexander Chow, Jacob C. Langer, Robin S. McLeod, Mark S. Silverberg, Anne M. Griffiths

M1152

Long-Term Outcomes in Infliximab Recipients Are Independent of Concomitant Immunomodulator Use in Patients with Crohn's Disease Alan C. Moss*, Kyung Jo Kim, Nielsen Q. FernandezBecker, Didia B. Cury, Adam S. Cheifetz

M1153

New Serological Markers for Inflammatory Bowel Disease Are Associated with Earlier Age At Onset, Complicated Disease Behavior, Risk for Surgery, and NOD2/CARD15 Genotype in a Hungarian IBD Cohort Maria Papp*, Istvan Altorjay, Nir Dotan, Palatka Karoly, Tamas Dinya, Laszlo Lakatos, Agota Kovacs, Tamas Molnar, Zsolt Tulassay, Pal Miheller, Gary L. Norman, Tamas Szamosi, Janos Papp, Peter L. Lakatos

M1154

Fatigue and Abdominal Bloating Predict Small Intestinal Bacterial Overgrowth (SIBO) in Patients with Ulcerative Colitis (UC) Patricio Ibanez*, Mark Pimentel, Gil Y. Melmed, Andrew Ippoliti, Stephan R. Targan, Eric A. Vasiliauskas

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL M1155

Bone Mineral Density and Biochemical Markers of Bone Turnover in Patients with Inflammatory Bowel Disease Sachiko Nakajima*, Hideki Iijima, Shinichiro Shinzaki, Satoshi Egawa, Jumpei Kondo, Shuji Ishii, Yoshimi Kakiuchi, Tsutomu Nishida, Masahiko Tsujii, Shingo Tsuji, Norio Hayashi

M1166



PepT1 Associated with Lipid Rafts Modulates BacterialEpithelial Interactions Hang Thi Thu Nguyen*, Guillaume Dalmasso, Shanthi V. Sitaraman, Didier Merlin

M1167

GEF-H1 Mediates NOD1 Dependent NF-kB Activation Initiated By Shigella Flexneri Effectors Carmen Alonso Cotoner*, Atsuko Fukazawa, Beth McCormick, Bayasi Guleng, Seiji Arihiro, Sonal Gupta, Hans-Christian Reinecker

M1168

Citrobacter rodentium Lifa Glucosyltransferase and Protease Motif Regulate Specific Members of Tight Junctions and Adherens Junctions Maiko Sasaki*, Brian A. Babbin, Asma Nusrat, Jan-Michael A. Klapproth

M1169

NF-kB Mediated-Transcriptional Regulation of a Cellular MicroRNA, LET-7i, Contributes to Biliary Epithelial Immunity Against Cryptosporidium Parvum Infection Patrick L. Splinter*, Steven P. O'Hara, Christy E. Trussoni, Gabriella Bedekovicsne Gajdos, XianMing Chen, Nicholas F. LaRusso

M1170

STAT3 in Intestinal Epithelium Regulates Cell Polarity and Protects from Enteropathogenic Bacteria Jongdae Lee*, Eyal Raz, Shee Eun Lee

M1171

Clostridium difficile Infection in Patients Admitted for An IBD Flare Vinay K. Katukuri*, Akbar K. Waljee, Jacob K. Kurlander, Yong Kwon, Peter D. Higgins, Ji Zhu, Ellen M. Zimmermann

Myosin II-Dependent Membrane Translocation of SGLT1 and Aqp1 Is Required for Efficient C. Parvum Cellular Invasion of Cholangiocytes Steven P. O'Hara*, Gabriella Bedekovicsne Gajdos, Bing Q. Huang, Patrick L. Splinter, XianMing Chen, Nicholas F. LaRusso

M1173

Impact of Pre-Colectomy Platelet Counts On the Occurrence of Crohn's Disease of the Pouch and Pouchitis Lei Lian*, Victor W. Fazio, Feza H. Remzi, Jeffery Hammel, Bo Shen

Paraepithelial Passage of Adherent Luminal Bacteria via Modified Cell-Cell-Contacts in Crohn's Disease Katrin Menzel*, Claudia Hofmann, Florian Obermeier, Josef Schroder, Ernst Holler, Werner Falk, Jurgen Scholmerich, Gerhard Rogler

M1174

Enteropathogenic E. coli-Induced Barrier Function Alteration Is Not a Consequence of Host Cell Death Andrew W. Weflen*, Athanasia Koutsouris, Sandhya V. Royan, Jennifer L. Roxas, V. K. Viswanathan, Gail Hecht

M1175

Mice with Gut Flora Reduced By Antibiotics Suffer Increased Intestinal Injury After Gamma-Irradiation Christopher Chang

M1176

Differential Expression of Aquaporins in GI Nematode Infection Kathleen B. Madden*, Aiping Zhao, Rex Sun, Diana C. Riera, Ildy M. Katona, Joseph F. Urban, Terez SheaDonohue

M1177

Cell Surface Binding and Internalisation of Clostridium difficile Toxin a By Human Intestinal Epithelial Cells Katie Solomon*, Adrian Robins, Yashwant R. Mahida

M1178

Pathogenic and Commensal Escherichia coli Decrease Cyclic-AMP Mediated Ion Secretion in Human Intestinal Epithelial Cells Christina L. Alexander*, Wallace K. MacNaughton

M1179

Presence of Escherichia coli in Ileal Mucosal Biopsy Samples Is Not Dependant On Alpha-Defensin Levels or NOD2 Status Daniel C. Burger*, Lisa Simms, James Doecke, Flavia Huygens, Graham L. Radford-Smith

M1180

Heat Labile Enterotoxin from E. coli Increases Permeability of T84 Monolayers Roderick B. Kreisberg*, Maura C. Strauman, James P. Nataro

M1181

Mechanism of Epithelial CCL20 Response to Listeria Sinead C. Corr*, Ann O'Hara, Liam O'Mahony, Kenneth Nally, Fergus Shanahan, Colin Hill, Cormac G. Gahan

M1156

Review of Medical Rescue Therapies in Patients with Severe, Acute Ulcerative Colitis Requiring Hospital Admission Adam V. Weizman*, A. Hillary Steinhart

M1157

Clinical Factors Contributing to Thromboembolic Complications in Patients with Inflammatory Bowel Disease Murtaza Arif*, Ashwin N. Ananthakrishnan, Dawn B. Beaulieu, Mazen Issa, Susan Skaros, Joshua F. Knox, Kathryn Lemke, Sarah J. Lundeen, Mary F. Otterson, David G. Binion

M1158

M1159

M1160

M1161

Passive Smoking During Childhood Increases the Risk for Intestinal Surgery in Patients with Crohn's Disease Donata Lissner*, Walter Reinisch, Pavol Papay, Elien Ho, Cornelia Gratzer, Clemens Dejaco, Gottfried Novacek, Harald Vogelsang, Wolfgang Miehsler Colonoscopic Surveillance for Dysplasia and Colorectal Cancer in Long-Standing Ulcerative Colitis: A Cohort Italian Study Sandro Ardizzone*, Matteo Bosani, Andrea Cassinotti, Paolo Fociani, Gianluca Sampietro, Alessandro Massari, Lucia Ferrari, Gabriele Bianchi Porro

M1162

Prevalence of Osteonecrosis in Patients with Inflammatory Bowel Disease; a Descriptive Review Wojciech Blonski*, David Kotlyar, Faten Aberra, James D. Lewis, Gary R. Lichtenstein

M1163

Depression in Inflammatory Bowel Disease Patients Katja Grubelic Ravic, Zeljko Krznaric*, Silvija CukovicCavka, Marko Brinar, Marina Grubic, Boris n. Vucelic

M1164

History of Medical Hospitalization Predicts Future Need for Colectomy in Patients with Ulcerative Colitis Ashwin N. Ananthakrishnan*, Mazen Issa, Dawn B. Beaulieu, Susan Skaros, Joshua F. Knox, Kathryn Lemke, Jeanne Emmons, Sarah J. Lundeen, Mary F. Otterson, David G. Binion

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

EPITHELIAL CELLS - MICROBIAL INTERACTIONS Participants will be able to: • Recognize the basic aspects of microbial interactions. M1165



Bacterial Effector Avra Stabilizes Cell Tight Junctions to Inhibit Inflammation in Intestinal Epithelial Cells Anne P. Liao, Elaine O. Petrof, Sumalatha Kuppireddi, Erika C. Claud, Jun Sun*

Denotes DDW Poster of Distinction

P-195

M O N D A Y MAY 19

POSTER SESSIONS—CLINICAL AGA Institute Poster Session 8:00 AM - 5:00 PM

M1192

Involvement of Serca and Phospholamban DownRegulation in the Impaired Contractile Responses of Colon Smooth Muscles in DSS-Induced Murine Model of Colitis Sadeea Qureshi*, Grant W. Hennig, Terence K. Smith, James L. Kenyon, Brian A. Perrino

M1193

Resveratrol Decreases Intestinal Smooth Muscle Cell Proliferation and Collagen Synthesis Phyllissa Schmiedlin-Ren*, Jason S. Mathias, Patricia Garcia, Huaijing Tang, Gregory M. Christman, Ellen M. Zimmermann

M1194

Expression of Bactericidal/Permeability-Increasing Protein (BPI) Is Increased in Patients with Ulcerative Colitis At An Early Stage Rieko Ogura*, Michiko Yamagata, Kazunari Kanke, Mitsunori Maeda, Masahiro Tsubaki, Motoo Ishida, Hironori Masuyama, Akira Terano, Hideyuki Hiraishi

M1195

GM-CSF: Potential Anti-Inflammatory and Antifibrotic Mediator in Intestinal Myofibroblasts Jamal I. Saada*, Iryna V. Pinchuk, Randy C. Mifflin, Don W. Powell

M1196

Colonic Epithelial Galectin-3 Redistributes from Nucleus to Cytoplasm, Is Secreted and Protects Against Apoptosis Under Experimental Acute Inflammatory Conditions Anne Mathieu*, Nathalie Nagy, Patrick R. Dumont, Alix Berton, Claude A. Cuvelier, Liesbeth Ferdinande, Christine Decaestecker, Isabelle Salmon, Pieter Demetter Breast Cancer Resistance Protein (BCRP/ABCG2) Is Equally Distributed Throughout the Colon of Patients with Ulcerative Colitis and Its Expression Is Decreased in Active Inflammation C. L. Koelewijn*, M. M. Gerrits, H. J. Verhoog, Herman van Dekken, E. J. Kuipers, Christien J. van der Woude

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IBD: NONIMMUNE CELL FUNCTION, ACTIVATION AND REGULATION Participants will be able to: • Evaluate recent basic research on nonimmune cell function, activation and regulation. M1182



A33 Antigen-Deficient Mice Are Unable to Resolve Mucosal Damage Caused By TNBS Colitis Prue M. Pereira-Fantini*, Louise M. Judd, Anastasia Kalantzis, Anthony J. Peterson, Joan K. Heath, Matthias Ernst, Andrew S. Giraud

M1183

Deferential Upregulation of PD-L1 and PD-L2 Expression via TLR4 and TLR5 Mediated Signals On Colonic Myofibroblasts Iryna V. Pinchuk*, Ellen J. Beswick, Jamal I. Saada, Victor E. Reyes, Don W. Powell



M1184

Specific Alteration of MicroRNA Expression in Inflammatory Bowel Disease Xavier Treton*, Magali Fasseu, Yoram Bouhnik, Jean Claude Soulé, Aparicio Thomas, Dominique Cazals-Hatem, Marc C. Laburthe, Eric Ogier-Denis

M1185

High Fecal Serine-Protease Activity in IBD Patients Triggers Alterations of Paracellular Permeability in Mice Colon Through Par 4 Receptor Activation Marta Dabek*, Laurent Ferrier, Gilles Chaumaz, Christel Salvador-Cartier, Krisztina Gecse, Jacques Moreau, Louis Buscail, Jean Escourrou, Jean Fioramonti, Vassilia Theodorou, Lionel Bueno

M1197

M1186

Endothelial-to-Mesenchymal Transition of Intestinal Mucosal Microvascular Cells: A Novel Mechanism of Intestinal Fibrosis Florian Rieder*, Gail West, Claudio Fiocchi

AGA Institute Poster Session 8:00 AM - 5:00 PM

M1187

M O N D A Y

Iron Deficiency Increases DNA-Ploidy of Megakaryocytic Cells and Consecutive Platelet Counts in IBD Stefanie Kulnigg*, Rayko Evstatiev, Georg Haymerle, Christoph Gasche

M1188

Cigarette Smoking in Inflammatory Bowel Disease: Cell Cycle Arrest May Explain the Divergent Effects in Crohn's Disease and Ulcerative Colitis Garret Cullen*, Miriam Tosetto, Sheeona Gorman, Hugh Mulcahy, Diarmuid P. O'Donoghue, Jacintha O'Sullivan

M1189

Activation of NF-kB By NOD2 in Human Intestinal Epithelial Cells Tiphanie P. Vogel, James P. Lodolce, Mark Logsdon, Sarah Bartulis, Melisa Burn, Jeff Schneider, Lauren Kolodziej, Jeannette S. Messer, Jonathan Chang, David L. Boone*

M1190

Expression and Functional Analysis of Intestinal Organic Cation/L-Carnitine Transporter (OCTN) in Crohn's Disease Marc Girardin*, Ijaz A. Qureshi, Serge Dionne, Robert Battat, Alain Bitton, Patrick Charlebois, Gary E. Wild, Kevin A. Waschke, Ernest G. Seidman

M1191

Cdc14A As a Candidate Regulating Iron-Dependent DNA Ploidy in Megakaryocytes Rayko Evstatiev*, Stefanie Kulnigg, Christoph Gasche

MAY 19

P-196

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

PROBIOTICS IN INTESTINAL INFLAMMATION, INFECTION AND IBD Participants will be able to: • Recognize the basic aspects of probiotics in intestinal inflammation, infection and IBD. M1198



Lactobacillus Rhamnosus GG Prevents Radiation Induced-Small Intestinal Injury in a MyD88 Independent, But COX-2 Dependent Manner Matthew A. Ciorba*, Terrence Riehl, Yoon-Jung Hyun, William Stenson

M1199

Counterbalancing Dysbiosis in Crohn's Disease: Faecalibacterium prausnitzii, a Major Commensal Bacterium, Exhibits In Vitro and In Vivo AntiInflammatory Effects Harry Sokol*, Benedicte Arnaud-Pigneur, Laurie Watterlot, Omar Lakhdari, Hervé M. Blottiere, Corinne Grangette, Germain Trugnan, Joel M. Dore, Ginette Thomas, Philippe R. Marteau, Philippe Seksik, Philippe Langella

M1200

Probiotic E. coli (Symbioflor®2) Treatment Mediates Antimicrobial β-Defensin (HBD-2) Synthesis and Fecal Excretion in Humans Miriam Schlee, Kurt Zimmermann, Hermann Huber, Klaus Fellermann, Eduard Stange, Jan Wehkamp*

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL M1201

M1202

Bacillus Polyfermenticus, a Novel Probiotic Microbe, Ameliorates Colonic Inflammation in Experimental Colitis Models via TLR2 and TLR4 Eunok Im*, Yoon Jeong Choi, Charalabos Pothoulakis, Sang Hoon Rhee Effective Probiotic Treatment (VSL#3), But Not Placebo, in Acute Ulcerative Colitis Is Associated with DownRegulation of Inflammatory Intestinal Dendritic Cells Siew C. Ng*, Sophie Plamondon, Ailsa L. Hart, Michael A. Kamm, Stella C. Knight, Andrew J. Stagg

Participants will be able to: • Evaluate clinical advances in celiac disease.

M1213

Time-Course Assessment of the Celiac Disease-Specific Serology After Initiation of a Gluten-Free Diet Emilia Sugai, Fabio Nachman, Horacio Vazquez, Andrea Gonzalez, Paola J. Andrenacci, Andrea Czech, Sonia Niveloni, Roberto M. Mazure, Edgardo Smecuol, Eduardo Mauriño, Julio C. Bai*

M1214

Aberrant T-Lymphocytes in Refractory Celiac Disease Are Not Strictly Confined to a Small Intestinal Intraepithelial Localization Wieke H. Verbeek*, B. Mary E. von Blomberg, Joost Oudejans, Chris J. Mulder, Marco W. Schreurs

M1215

The Differential Diagnosis of Persisting Villous Atrophy: There Is More Than Refractory Celiac Disease Wieke H. Verbeek*, B. Mary E. von Blomberg, Chris J. Mulder, Marco W. Schreurs

M1216

Six Small Bioactive Peptides Identified from Lactobacillus GG Cultured Supernatant Ruiliang Lu*, Nandakumar Madayiputhiya, Alessio Fasano

Significant Numbers of Celiac Patients On a Gluten-Free Diet Do Not Meet RNI Targets for Micronutrients Gerry Robins*, Dianne Wild, Peter Howdle

M1217

Clostridium difficile Complicating Inflammatory Bowel Disease: Pre- and Post-Treatment Findings Thomas J. Borody*, Antony R. Wettstein, Sharyn Leis, Lauren A. Hills, Jordana Campbell, Margaux Torres

Female Celiac Patients On a Gluten-Free Diet Consume a Disproportionate Amount of Non-Milk Extrinsic Sugars Gerry Robins*, Dianne Wild, Peter Howdle

M1218

Celiac Disease Diagnosis: Has Come Time to Change Gold Standard? Antonio Picarelli*, Marco Greco, Giuseppe Donato, Valerio Libanori, Daniela De Nitto, Luigi Sabbatella, Anna Rita Saponara, Anna Vallecoccia, Marco Di Tola, Stefania Uccini

A Randomized Trial On the Quality of Life Efficacy of Synbiotic Treatment Versus Probiotics or Prebiotics in Patients with Ulcerative Colitis Shunji Fujimori*, Katya Gudis, Atsushi Tatsuguchi, Yoko Takahashi, Yukie Yamada, Yoshihisa Sekita, Masaoki Yonezawa, Choitsu Sakamoto

M1205

The Effect of Prebiotics On Tight Junction and Barrier Function of Enteric Epithelium of Cold Restrain Stress (CRS)-Exposed Rats Ting Xie, Jun Gao*, Duowu Zou, Yu Bai, Zhaoshen Li

M1206

Lactulose Use Is Associated with Decreased Nosocomial Clostridium difficile Infection Andrew D. Rhim*, Neil Mehta, Reena Chokshi, Faten Aberra, Leanne Gasink, Yu-Xiao Yang

M1207

A Randomized Controlled Trial of VSL#3 for the Prevention of Endoscopic Recurrence Following Surgery for Crohn's Disease Karen Madsen, Jody l. Backer, Des Leddin, Levinus A. Dieleman, Alain Bitton, Brian Feagan, Denis M. Petrunia, Naoki Chiba, Robert A. Enns, Richard Fedorak*

M1211

CELIAC DISEASE: CLINICAL ADVANCES II



M1204

M1210

Sponsored by: Intestinal Disorders

Celiac Disease Serology with Very High Accuracy May Obviate Diagnostic Intestinal Biopsy in Different Clinical Scenarios Emilia Sugai, María Laura Moreno, Hui Jer Hwang, Adriana Crivelli, Fabio Nachman, Horacio Vazquez, Sonia Niveloni, Julio E. Argonz, Roberto M. Mazure, Graciela La Motta, Maria E. Caniggia, Edgardo Smecuol, Ana Cabanne, Nestor Chopita, Juan Gomez, Eduardo Mauriño, Julio C. Bai*

Synbiotics Modulate Intestinal Epithelial-Dendritic Cell Interactions in the Mdr1a-/- Mouse Model of Colitis: Role in Prevention of Disease Silvia C. Resta-Lenert*, Kim E. Barrett

M1209

Sails Pavilion San Diego Convention Center

M1212

M1203

M1208

AGA Institute Poster Session 8:00 AM - 5:00 PM

Anti-Inflammatory Effects of Bifidobacteria On Macrophages By Modification of Proinflammatory Cytokines and SOCS Signals Yoshikiyo Okada*, Ryota Hokari, Yoshikazu Tsuzuki, Koichi Takebayashi, Hisayuki Matsunaga, Shunsuke Komoto, Chikako Watanabe, Chie Kurihara, Mitsuyasu Nakamura, Atsushi Kawaguchi, Shigeaki Nagao, Kazuro Itoh, Soichiro Miura Anti-Inflammatory Effect of Novel Lactobacillus Isolated from Japanese “Funazushi” On DSS-Induced Colitis Yoshikiyo Okada*, Yoshikazu Tsuzuki, Naoko Ishida, Ryota Hokari, Hisayuki Matsunaga, Koichi Takebayashi, Shunsuke Komoto, Chikako Watanabe, Chie Kurihara, Mitsuyasu Nakamura, Atsushi Kawaguchi, Shigeaki Nagao, Kazuro Itoh, Tadao Watanabe, Soichiro Miura

M1219

Patients of South East Asian Origin with Coeliac Disease: A Retrospective Case-Control Study of Attendance and Outcomes Compared with Caucasians Nishchay Chandra*, Nasreen Imrit, David Gorard, Alistair McIntyre

M1220

The Proportion of Celiac Disease in Common Gastroenteropaties Among Iranian Patients Mohammad Rostami Nejad, Kamran Rostami*, Mohamad Amin Pourhoseingholi, Ehsan Nazemalhosseini Mojarad, Maryam Sanaei, Hosein Dabiri, Mohammad Reza Zali

M1221

Anorectal Function and Visceral Hypersensitivity in Celiac Disease Agata Mulak*, Ewa Waszczuk, Leszek Paradowski

M1222

How Adequate Is the Information Available On the Internet for Patients with Celiac Disease? Susan J. Algert*, Kristin Landa, Michael Donohue, Martin F. Kagnoff

M1223

Prevalence of Celiac Disease in the Adult Population in Israel Eran Israeli, Tiberiu Hershcovici*, Itamar Grotto, Zvi Roach, Eran Goldin

Denotes DDW Poster of Distinction

P-197

M O N D A Y MAY 19

POSTER SESSIONS—CLINICAL M1224

Routine Duodenal Biopsy Is a Cost-Effective Way to Increase the Yield of Diagnosing Coeliac Disease in Patients Undergoing Upper Gastrointestinal Endoscopy Alexander A. Simring*, Guy D. Eslick, Jamshid S. Kalantar

M1225

Effect of Gluten-Free Diet in Body Mass Index in Celiac Patients Valeria Pogorelsky, Federico Tobal*, Daniel Tobal

M1225a

A Report On the 2007 International Transglutaminase Autoantibody Workshop for Celiac Disease Marcella M. Li, Liping Yu, Claudio Tiberti, Margherita Bonamico, Dongmei Miao, Joseph a. Murray, Marian J. Rewers, Edward J. Hoffenberg, Martin Stern, Ezio Bonifacio, Edwin Liu*

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

M1233

Expression of Growth Factor Receptor and Potential Treatment in Cholangiocarcinoma (CC) Cell Lines Ling Xu*, Theresa Pesch, Silvia Kellermeier, Werner Falk, Jürgen Schölmerich, Michael Fried, Frank Klebl, Gerhard Rogler

M1234

Randomized Prospective Study with a Intravenous Anesthesia (Propofol) for Radiofrequency Thermal Ablation (RFA) in Hepatic Neoplasms Shinpei Sato*, Akishige Yamada, Tatsuya Minami, Shintaro Mikami, Akemi Takada, Tenyu Motoyama, Satoru Yotsuya, Teruyuki Tanaka, Shintaro Kondo, Nobuo Toda

M1235

Deguelin As a New Therapeutic Candidate for the Treatment of Hepatocellular Carcinoma Ju-Hee Lee*, Soon-Sun Hong, Seok Jeong, Don Haeng Lee, Hyung Gil Kim, Yong Woon Shin, Young Soo Kim

M1236

Linear EUS Assessment and EUS-Fine Needle Aspiration of Hilar Lesions Manu K. Nayar*, Derek Manas, Mark Egan, Viney Wadehra, Kofi Oppong

Sponsored by: Liver & Biliary

LIVER AND BILIARY CARCINOMA: MANAGEMENT Participants will be able to: • Learn about hepatocellular carcinoma; • Learn about biliary carcinoma; and • Learn to manage liver and biliary carcinoma. M1226

M1227

M O N D A Y

Prognostic Factors of Hepatocellular Carcinoma with Decompensated Cirrhosis Kazuhiro Nouso*, Yoichi M. Ito, Kenji Kuwaki, Shuji Uematsu, Kunihiro Shiraga, Ryoichi Okamoto, Shinichiro Nakamura, Yoshiyuki Kobayashi, Yasuyuki Araki, Kohsaku Sakaguchi, Yasuo Ohashi, Kazuhide Yamamoto Efficacy and Low-Invasiveness of Radiofrequency Ablation Therapy for Hepatocellular Carcinoma in Elderly Patients Atsushi Hiraoka*, Norio Horiike, Hirokazu Doi, Yohei Koizumi, Yasunori Yamamoto, Soichi Ichikawa, Aki Hasebe, Makoto Yano, Yasunao Miyamoto, Tomoyuki Ninomiya, Ichiro Sogabe, Yoshihiro Ishimaru, Masao Miyagawa, Hideki Kawasaki, Masashi Hirooka, Bunzo Matsuura, Morikazu Onji

M1228

Percutaneous Radio-Frequency Ablation Improves the Prognosis of the Patients with Unresectable Hepatic Metastasis from Colorectal Cancer Yukihiro Koike*, Haruhiko Yoshida, Shuichiro Shiina, Hirofumi Kogure, Masao Omata, Tateo Kawase

M1229



Comparative Outcomes for Biliary Papillomatosis Treated with Intraluminal Iridium-192 Brachytherapy Combined with External Radiotherapy and Conservative Treatment Eun Taek Park*, Sang Hyuk Lee, Youn Jae Lee, Sam Ryong Jee, Sung Jae Park, Ji Hyun Kim, Jung Hee Yun, Ki Jung An, Hae Kyung Yun, Sang Young Seol

M1230

Thymidylate Synthase Expression May Be Related to the Antitumor Effect of S-1 in Patients with Biliary Tract Cancer Tetsuo Ajiki*, Haruki Morimoto, Tsunenori Fujita, Taku Matsumoto, Kenro Hirata, Yonson Ku

M1231



Mechanism of Antitumor Effect of S-1 Against Gallbladder Cancer in An In Vivo Model Haruki Morimoto*, Tetsuo Ajiki, Tsunenori Fujita, Kenro Hirata, Taku Matsumoto, Hirokazu Fukui, Takahiro Fujimori, Yonson Ku

M1232

Prognostic Factors of the Patients with Hilar Cholangiocarcinoma Treated By Palliative Management Si Hyung Lee*, Kyeong Ok Kim, Sang Hoon Lee, Jong Ryul Eun, Byung Ik Jang, Tae Nyeun Kim

MAY 19

P-198

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility

RECEPTORS: EXTRA-AND INTRACELLULAR SIGNALING Participants will be able to: • Evaluate recent research in receptors: Extra- and intracellular signaling. M1237



Dopamine D1 and D2 Receptor Subtypes Are Involved in Enteric Neural Control of Chloride and Bicarbonate Secretion in Guinea Pig Duodenum Yun Xia*, Xiyu Wang, Guo-Du Wang, Fie Zou, Guijun Fei, Sumei Liu, Mei-Hua Qu, Xiaohong Sun, Wei Ren, Jackie D. Wood

M1238

Peptide YY Acts Through Y2 Receptors to Inhibit Stimulated Colonic Motor Function in Conscious Mice Lixin Wang*, Guillaume Gourcerol, Pu-Qing Yuan, Mulugeta Million, Muriel H. Larauche, Yvette Tache

M1239

Alterations in Synaptic Transmission in the Enteric Nervous System and Correlation to Motility Defects in CB1 Receptor-Deficient Mice Ian M. Hons*, Catherine M. Keenan, Martin Storr, Beat Lutz, Keith A. Sharkey

M1240

The Roles of Serotonin 5-HT2C and 3 Receptors in Anorexia and Delayed Gastric Emptying in CisplatinTreated Rats Koji Yakabi*, Susumu Kurosawa, Tomohisa Hattori, Yuzurihara Mitsutoshi, Shino Ohno

M1241

Contractile and Secretory Responses of Luminal ShortChain Fatty Acids and the Expression of These Receptors, GPR41 and GPR43, in the Human Small and Large Intestines Shin-ichiro Karaki*, Hideaki Tazoe, Izumi Kaji, Yasuko Otomo, Takaji Yajima, Atsukazu Kuwahara

M1242

Pharmacological Characterization of Murine Lower Esophageal Sphincter (LES) Relaxation Scott Carmichael*, John Sauvé, David V. Miller, Yong Zhang, William G. Paterson

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL AGA Institute Poster Session 8:00 AM - 5:00 PM

M1258

Non Alcoholic Fatty Liver Disease in Japanese Patients with Severe Obesity Who Received Laparoscopic Rouxen-Y Gastric Bypass Surgery (LRYGB) in Comparison to Non-Japanese Patients Satoru Kakizaki*, Daichi Takizawa, Yuichi Yamazaki, Tatsuya Ohyama, Naondo Sohara, Takeshi Ichikawa, Ken Sato, Hitoshi Takagi, Masatomo Mori, Kazunori Kasama

M1259

Routine Management of Stricture After Gastric Bypass and Predictors of Subsequent Weight Loss Kira L. Ryskina*, Kenneth M. Miller, James Aisenberg, Daniel M. Herron, Subhash U. Kini

Sails Pavilion San Diego Convention Center

Sponsored by: Nutrition & Obesity

SURGICAL AND ENDOSCOPIC MANAGEMENT OF OBESITY Participants will be able to: • Evaluate recent research on the surgical and endoscopic management of obesity. M1248

M1249

Bacterial and Fungal Colonization of Endoscopic Intragastric Balloons Inserted in Patients with Morbid Obesity John A. Karagiannis*, Nicoletta G. Mathou, Konstantia D. Paraskeva, Georgios K. Anagnostopoulos, Konstantinos Zografos, Nausika Kontostergiou, Stamatina Konstantinou, Zoi Roussou Peroral Endoscopic Anastomotic Reduction Improves Intractable Dumping Syndrome in Roux-en-Y Gastric Bypass Patients Gloria Fernandez-Esparrach*, David B. Lautz, Christopher C. Thompson

M1250

Improvement of Serum C-Reactive Protein Level in Obese Chinese Patients Undergoing Endoscopic or Laparoscopic Bariatric Procedures Enders K. Ng*, Bonnie Y. Tsung, Candice C. Lam, Man Yee Yung, Wilfred L. Mui

M1251

Predictive Factors for Body Weight Control and Quality of Life in Obese Patients Treated with Endoscopic Bioenteric Intragastric Balloon Enders K. Ng*, Bonnie Y. Tsung, Candice C. Lam, Man Yee Yung, Frances K. Cheung, Philip W. Chiu, Wilfred L. Mui

M1252

Use of Pharmacotherapy for Long-Term Maintenance of Weight Loss Following Explantation of Intragastric Balloon Evzen Machytka*, Pavel Klvana, Lada Hanuskova, Igor Janik

M1253

Treatment of Weight Regain Following Gastric Bypass Surgery Using a Novel Endoscopic Device: Technical Feasibility and Early Outcomes in Twenty Patients Daniel K. Mullady*, David B. Lautz, Christopher C. Thompson

M1254

M1255

Safety and Functionality of Gastric Electrical Stimulation with TANTALUS® On Glycemic Control in Overweight Subjects with Type 2 Diabetes - Results of a Clinical Feasibility Study On An Investigational Device Claudia P. Sanmiguel*, Jeffrey L. Conklin, Mark Kipnes, John Pilcher, Scott A. Cunneen, Philip Barnett, Edward H. Phillips, Edy E. Soffer

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Pancreatic Disorders

CLINICAL ACUTE PANCREATITIS: PREDICTING SEVERITY Participants will be able to: • Understand the importance of accurately predicting severe acute pancreatitis in directing management. M1260



Increased Levels of Soluble Triggering Receptor Expressed On Myeloid Cells-1 (sTREM-1) in Patients with Acute Pancreatitis Keiko Kamei*, Takeo Yasuda, Yoshifumi Takeyama, Takashi Ueda, Makoto Shinzeki, Hidehiro Sawa, Yonson Ku, Yoshikazu Kuroda, Harumasa Ohyanagi

M1261

Rapid Detection of Soluble Triggering Receptor Expressed On Myeloid Cells and the Diagnosis of Secondary Infection in SAP Zheng Lu*, Yan Liu

M1262

A Meta-Analysis of Interleukin-6 and Interleukin-8 As Early Markers of Severe Acute Pancreatitis Joy S. Chen*, Elie Aoun, Ferga C. Gleeson, David C. Whitcomb, Georgios I. Papachristou

M1263

Assessment of Relative Pancreatic and Systemic Cytokine Responses in Patients with Severe Acute Pancreatitis Amit Raina*, Junhai Ou, Refaat Hegazi, Stephen J. O'Keefe

M1264

ND-07, a Compound Synthesized from Salicylate, Ameliorated Acute Pancreatitis in Several Animal Models; Candidate for Novel Therapeutics Jin Hwan Lee*, Chun San An, Bok-Seon Yoon, Sung Ig Cho, Jaeyoung Cho, Heajin Sim, Byoung Joo Gwag, Ki-Baik Hahm

M1265

Predicting ICU Admission and Mortality in Acute Pancreatitis: A Six Year Retrospective Single Center Experience Comparing Ranson and Sepsis-Related Organ Failure (SOFA) Scores in the Emergency Room and At 48 Hours Ari J. Wiesen*, Mirela Meca, Kostas Sideridis, Jaydeep Kadam, Arkady Broder, Steven Helft, Brian J. Schwender, Simmy Bank

Intra-Abdominal Vagal Blocking Reduces Calorie Intake, Enhances Satiation and Reduces Hunger During Significant and Sustained Weight Loss in Obese Subjects James Toouli*, Lilian Kow, Jane Collins, Nicholas H. Wray, Katherine S. Tweden, Mark C. Vollmer, Richard R. Wilson, James W. Freston, Charles J. Billington

M1266

M1256

Endoluminal Bariatric Surgery: An Experimental Proposal for Implantable Gastric Bypass Nicola Di Lorenzo*, Marc O. Schurr, Ida Camperchioli, Valeria Tognoni, Giorgio Coscarella, Achille Lucio Gaspari

Factors Associated with Increased Costs for Hospital Admissions Due to Acute Pancreatitis Devi Mukkai Krishnamurty, Jonathan M. Buscaglia*, Sumit Kapoor, Sanjay B. Jagannath, Patrick Okolo

M1267

M1257

The Impact of Adjustable Laparoscopic Gastric Banding On Esophageal Motility in Patients with Abnormal Preoperative Manometry Zoi Gamagaris*, Carlie Patterson, Fritz Francois, Christine R. Fielding, George A. Fielding, Morris Traube, Heekoung A. Youn, Elizabeth H. Weinshel

Factors Associated with Hospital Death in Patients Admitted with Pancreatitis Jonathan M. Buscaglia*, Sumit Kapoor, Eun Ji Shin, Patrick Okolo



Denotes DDW Poster of Distinction

P-199

M O N D A Y MAY 19

POSTER SESSIONS—CLINICAL M1268

Hemeoxygenase-1 Is Induced in Peripheral Blood Mononuclear Cells of Patients with Acute Pancreatitis: A Potential Therapeutic Target Aida Habtezion*, Raymond Kwan, Alice L. Yang, Maureen E. Morgan, Ehsaan Akhtar, Stephen P. Wanaski, Stephen M. Collins, Eugene Butcher, Ahmad Kamal, Bishr Omary

M1269

Lack of Aggressive Early Fluid Resuscitation Is Associated with Organ Failure in Acute Pancreatitis Timothy B. Gardner*, Suresh T. Chari, Mario Pelaez-Luna, Ferga C. Gleeson, Bret T. Petersen, Mark D. Topazian, Jonathan E. Clain, Randall K. Pearson, Michael J. Levy, Michael G. Sarr, Santhi Swaroop Vege

M1283

What Are the Criteria for Resuming Oral Diet in Acute Pancreatitis and Is There Any Differences in the Course of Disease Due to That Criteria? JungHo Eum, Byungmoo Yoo*, KyungRok Lee

M1284

Use of Angiotensin II Receptor Blockers May Decrease Risk of Acute Pancreatitis - a Nested Case-Control Study Tomas Sjöberg*, Luis A. Garcia Rodriguez, Mats Lindblad

M1285

Serum Concentrations of Leptin and Resistin As Acute Inflammatory Phase Factors in Patients with Acute Pancreatitis Ewa Malecka-Panas, Bartosz Lesniowski*, Anna Kumor

Risk Factors for Subsequent Mortality After Initial Admission for Severe Acute Pancreatitis Timothy B. Gardner*, Suresh T. Chari, Bret T. Petersen, Mark D. Topazian, Jonathan E. Clain, Randall K. Pearson, Michael J. Levy, Michael G. Sarr, Santhi Swaroop Vege

M1271

Does Timing of Transfer Influence Mortality in Acute Pancreatitis? Bechien U. Wu*, Richard S. Johannes, Darwin Conwell, Peter A. Banks

ASGE Poster Session 8:00 AM - 5:00 PM

Balthazar Grade of Early CT Scan Within 48 Hours in Acute Pancreatitis Correlates with Clinical Severity, But CT Severity Index Does Not Jimin Han*, Kyoung Chan Park, Ho Gak Kim, Jin Tae Jung, Joong Goo Kwon, Eun Young Kim, Joon Hyuck Choi

ESOPHAGUS

M1273

MAY 19

Persistent Organ Failure Is Associated with Increased Mortality and Morbidity in Acute Interstitial Pancreatitis Vikesh Singh*, Thomas L. Bollen, Kathryn Repas, Rie Maurer, Koenraad J. Mortele, Peter A. Banks

M1270

M1272

M O N D A Y

M1282

The Harmless Acute Pancreatitis Score: A Convenient New Means of Assessing Prognosis On Admission Evaluated in 1008 Patients with a First Attack of Acute Pancreatitis Paul G. Lankisch*, Bettina Weber-Dany, Katrin Hebel, Patrick Maisonneuve, Albert B. Lowenfels

M1274

Obesity in Acute Pancreatitis Patients: Correlation with Disease Severity and Performance of Apache-0 Score Paul G. Lankisch*, Bettina Weber-Dany, Patrick Maisonneuve, Albert B. Lowenfels

M1275

Time Trends in Incidence of Acute Pancreatitis in Lüneburg: A Population-Based Study Paul G. Lankisch*, Mirwais Karimi, Anja Bruns, Patrick Maisonneuve, Albert B. Lowenfels

M1276

Trypsinogen Activation Peptide (TAP) Predicts the Development of Pulmonary Insufficiency in Patients with Interstitial Pancreatitis Ian Wall*, Konstantin Vaisman, Nison Badalov, Jack Braha, Jian Jun Li, Scott M. Tenner

M1277

Quality of Life One Year After a Single Attack of Acute Pancreatitis B.W. Marcel Spanier*, Marcel.G.W. Dijkgraaf, Marco Bruno

M1278

Alcohol Use and Cumulative Cigarette Exposure Are New Risk Factors for Post-ERCP Pancreatitis. A CaseControl Study Anthony T. DeBenedet*, Trivellore E. Raghunathan, Jeffrey J. Wing, Erik-Jan Wamsteker, Matthew J. DiMagno

M1279

Does Anticoagulation for Venous Thromboembolism in Acute Pancreatits Result in Pancreatic and/or PeriPancreatic Bleeding? Samar Harris, Harris V. Naina*, Suresh T. Chari, Santhi Swaroop Vege

M1280

Delay of Cholecystectomy in Patients with Acute Gallstone Pancreatitis and Peripancreatic Fluid Collections: Incidence of Complications Enrique de-Madaria*, Juan Martínez, María Dolores Picó, Gema Soler, Laura Sempere, Miguel Pérez-Mateo

M1281

Utilization of Pancreatic Enzymes (PE) in the Emergency Rooms (ER): Any Lessons Learned? Brian Y. Ng*, Dhiraj Yadav

P-200

Sails Pavilion San Diego Convention Center

M1286

Frequency of Distal Esophageal Landmark Identification and Adherence to Biopsy Standards At Index Endoscopy in Patients Referred for Ablative Therapy for Barrett's Esophagus Stephen Kucera*, Sabo B. Tanimu, Jason B. Klapman, James S. Barthel

M1287

Correlation of Barrett's Histological Surveillance Biopsies Versus Final Endoscopic Mucosectomy Resection (EMR) Specimens: Are We Seeing the Forest or Just the Trees? Jennifer S. Chennat*, Vani J. Konda, Andrew S. Ross, Alberto Herreros de Tejada, Barbara M. Cislo, Lynne Stearns, Amy E. Noffsinger, John Hart, Charles E. Dye, Mitchell C. Posner, Mark K. Ferguson, Irving Waxman

M1288

Safety Profile of Single Session Complete Barrett's Esophagus Endoscopic Mucosal Resection (CBE-EMR) Jennifer S. Chennat*, Vani J. Konda, Andrew S. Ross, Alberto Herreros de Tejada, Barbara M. Cislo, Lynne Stearns, Charles E. Dye, Mitchell C. Posner, Mark K. Ferguson, Irving Waxman

M1289

The Prevalence of Barrett's Esophagus in Veteran Patients with and Without GERD Symptoms Undergoing Outpatient Colonoscopy Romeo F. Esquivel*, Vikram Boolchand, Navin Kumar, Lisa Camargo, Jimmy L. Kim, Ronnie Fass, Richard E. Sampliner

M1290

Diagnostic Yield of Methylene Blue Chromoendoscopy (MB) and Conventional 4-Quadrant Random Biopsy (RB) for Detecting Specialized Intestinal Metaplasia (SIM) and Dysplasia in Barrett's Esophagus (BE): A Meta-Analysis Saowanee Ngamruengphong*, Virender K. Sharma, Ananya Das

M1291

Assessment of Quality for Esophagogastroduodenoscopy Using the ASGE-ACG Quality Indicators Susan G. Coe*, David S. Loeb, Michael G. Heckman, Julia Crook, Michael B. Wallace

M1292

Diagnostic Accuracy of Methylene Blue Guided Chromoendoscopy in Patients with Suspicion of Dysplastic Barrett's Oesophagus Raf Bisschops*, Ingrid Demedts, Nadine Ectors, Karel Geboes, Jan F. Tack, Jozef Janssens, Paul J. Rutgeerts

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL M1293

Interobserver Variability of Methylene Blue Guided Chromoendoscopy in Patients with Suspicion of Dysplastic Barrett's Oesophagus Raf Bisschops*, Ingrid Demedts, Lamia Kallel, Karel Geboes, Jozef Janssens, Paul J. Rutgeerts

M1306

Recurrence of Neoplasia After Ablation of Barrett's Esophagus (BE) Rami J. Badreddine*, Kenneth K. Wang, Ganapathy A. Prasad, Navtej Buttar, Louis-Michel Wong Kee Song, Lori S. Lutzke, Kelly T. Dunagan, Lynn S. Borkenhagen

M1294

Fatty Acid Synthase Expression in Barrett's Esophagus and Its Detection in Endoscopic Surveillance Yuji Amano*, Yoshiko Takahashi, Norihisa Ishimura, Koichi Okita, Yuko Mishima, Alvaro A. Sanchez-Siles, Nobuyuki Moriyama, Shunji Ishihara, Yoshikazu Kinoshita

M1307

M1295

Clinical and Endoscopic Characteristics of a Large Cohort of Barrett's Esophagus (BE) Patients with Low and High-Grade Dysplasia Prateek Sharma*, Richard E. Sampliner, Brenda Hoffman, Blair A. Jobe, John G. Hunter, Nicholas J. Shaheen

Does Endoscopic Mucosal Resection (EMR) Affect Subsequent Esophagectomy? Rami J. Badreddine*, Kenneth K. Wang, Ganapathy A. Prasad, Louis-Michel Wong Kee Song, Navtej Buttar, Lynn S. Borkenhagen, Kelly T. Dunagan, Lori S. Lutzke, Dennis A. Wigle

M1308

Efficacy and Safety of Band Ligator Assisted Mucosal Resection to Completely Remove Barrett's Esophagus with High Grade Dysplasia or Early Cancer Junaid Siddiqui*, Henning Gerke

M1296

Autofluorescence Endoscopy Is Inferior to White Light Endoscopy for Detection of Dysplasia/Cancer in Barrett's Esophagus Surveillance Gary W. Falk*, Mary Oldenburgh, Lynn Schoenfield, Rocio Lopez

M1309

Surgical Versus Endoscopic Therapy for Barrett's Esophagus with Intramucosal Neoplasia: Determinants of Treatment Modality in a Tertiary Referral Center Patrick S. Yachimski*, Ethan Richards, Norman S. Nishioka, Chin Hur

M1297

Large Hiatal Hernia Is Associated with An Increased Frequency of Long Segment Versus Short Segment Barrett's Esophagus Humberto Sifuentes, Joshua Melson*, Srinadh Komanduri

M1310

M1298

A Strategy for Molecular Imaging of Barrett's Esophagus (BE) Jennifer L. Cutter, Michael J. Pollack*, Gary W. Falk, Beth Bednarchik, Nathan Cohen, M. Bogyo, Joseph Willis, Amitabh Chak, James P. Basilion

Endoscopy of Barrett's Esophagus Guided By Fluorescence Imaging Using An Overlay Imaging Technique Winfried A. Voderholzer, Marc Karliova*, Jörn Berger, Bernd Ebert, Rainer Macdonald, M. Dietel, Maria-Anna Ortner, Herbert Lochs

M1311

How Adequate Is Endoscopic Inspection of a Barrett's Esophagus with Early Neoplasia By Expert Endoscopists? An International Multi-Center Study with Complete Histological Correlation of the Whole Barrett's Segment Roos E. Pouw*, Stefan Seewald, Joep J. Gondrie, Pierre H. Deprez, Hubert Piessevaux, Thomas Roesch, Heiko Pohl, Nib Soehendra, Jacques J. Bergman

M1312

Invasive Cancer in Endoscopic Mucosal Resection Specimens of Non-Nodular Barrett's Esophagus: Implications for Ablative Therapy Cyrus R. Piraka*, B. Joseph Elmunzer, Richard S. Kwon, Joel H. Rubenstein

M1313

Endoscopic Submucosal Dissection Using Mucosectome for Adenocarcinoma of Esophagogastric Junction and Gastric Cardia Yoshiro Kawahara*, Ryuta Takenaka, Hiroyuki Okada, Kazuhide Yamamoto

M1299

Benefit of Baseline Cytometry As Add-On to Standard Histology On Surveillance in Patients with Barrett' Esophagus: Preliminary Results Nicole Vogt, René Schönegg, Juergen M. Gschossmann, Jan Borovicka*

M1300

Magnifying Endoscopic Observation with NBI (Narrow Band Imaging) for Specific Intestinal Metaplasia in Barrett's Esophagus with Special Reference to Light Blue Crest Yujiro Nakashima*, Hajime Isomoto

M1301

Ethnicity-Related Variations in the Prevalence and Demographics of Barrett's Esophagus Joe E. Khoury, Sian S. Chisholm, M Mazen Jamal, Sunitha Pudhota, Kenneth J. Vega*

M1302

Can Fluctuations in Pathologic Grade of Patients with Barrett's Esophagus Predict Progression? Adewale Ajumobi

M1303

Stepwise Radical Endoscopic Resection for Complete Removal of Barrett's Esophagus with Early Neoplasia: An International Multicenter Study Joep J. Gondrie, Stefan Seewald, Roos E. Pouw*, Hubert Piessevaux, Pierre H. Deprez, Heiko Pohl, Thomas Roesch, Nib Soehendra, Jacques J. Bergman

M1304

M1305

Results of Cryospray Ablation for Esophageal High Grade Dysplasia (HGD) and Intramucosal Cancer (IMCA) in High Risk Non-Surgical Patients John A. Dumot*, John J. Vargo, Gregory Zuccaro, Gary W. Falk, Lorraine Frey, Thomas Rice Subsquamous Intestinal Metaplasia Is a Common Finding in Ablation-Naive Patients with Dysplastic Barrett's Esophagus, and Significantly Decreases in Prevalence After Radiofrequency Ablation Nicholas J. Shaheen*, Mary P. Bronner, David E. Fleischer, Richard I. Rothstein, Virender K. Sharma, Charles J. Lightdale, Bergein F. Overholt, Glenn M. Eisen, Richard E. Sampliner, Prateek Sharma, Ana E. Bennett

M1314

No Evidence of Aspirin Chemoprotection in Barrett's Adenocarcinoma of the Esophagus? Piers A. Gatenby, James R. Ramus, Christine P. Caygill*, Marc C. Winslet, Anthony Watson

M1315

Optimizing Photodynamic Therapy Outcomes By the Determination of Mucosal Porfimer Sodium Concentration in Patients with Barrett's Dysplasia and Carcinoma Kanwar R. Gill*, Seth A. Gross, Linda R. Jones, Norris W. Preyer, Marquitta V. Scott, Michael B. Wallace, Herbert C. Wolfsen

M1316

Confocal Laser Microscopy (CLM) Guided Endoscopic Mucosal Resection in Barrett's Esophagus with High Grade Dysplasia Rami J. Badreddine*, Kenneth K. Wang, Ganapathy A. Prasad, Louis-Michel Wong Kee Song, Wytske Westra, Navtej Buttar, Lynn S. Borkenhagen, Kelly T. Dunagan, Lori S. Lutzke

M1317

Comparative Outcomes of Photodynamic Therapy and Radiofrequency Ablation for the Treatment of Barrett's Esophagus with High Grade Dysplasia Seth A. Gross*, Kanwar R. Gill, Herbert C. Wolfsen

Denotes DDW Poster of Distinction

P-201

M O N D A Y MAY 19

POSTER SESSIONS—CLINICAL M1318

M1319

Predictors of Histopathologic Response Following Photodynamic Therapy of Barrett's Esophagus with High-Grade Dysplasia or Intramucosal Carcinoma Patrick S. Yachimski*, William P. Puricelli, Norman S. Nishioka

M1320

Multifocal High-Grade Dysplasia (MFHGD) in Barrett's Esophagus Is Associated with Adenocarcinoma in Patients Undergoing Endoscopic Mucosal Resection (EMR) for Barrett's Esophagus Norio Fukami*, Alexander A. Dekovich, Matthew R. Sericati, Dipen Maru, Huamin Wang, Wayne L. Hofstetter

M1321

M1322

M1323

M1324

M O N D A Y

Low Flow CO2-Cryotherapy for High Risk Barrett's Esophagus (BE) Patients with High Grade Dysplasia and Early Adenocarcinoma: A Pilot Trial of Feasibility and Safety a Pilot Trial of Feasibility and Safety Marcia I. Canto*, Kerry B. Dunbar, Patrick Okolo, Sanjay B. Jagannath, Sergey V. Kantsevoy

Interim Analysis of Barrett's Esophagus Eradication By Radiofrequency Ablation Jose C. Hernandez*, David S. Chung, Binh V. Pham, Sonya Reicher, Franklin Tsai, Nittly Chahal-Sekhon, Guy DiSibio, Samuel W. French, Viktor E. Eysselein Burn, Freeze or Photo-Ablate? Comparative Symptom Profile in Patients with Barrett's High Grade Dysplasia Undergoing Endoscopic Ablation Seth A. Gross*, Kanwar R. Gill, Bruce D. Greenwald, Herbert C. Wolfsen A Promising New Combined Treatment Modality for Barrett's Esophagus Containing Early Neoplasia: Endoscopic Resection Followed By Step-Wise Circumferential and Focal Radiofrequency Energy Ablation Roos E. Pouw*, Joep J. Gondrie, Frederike G. Van Vilsteren, Carine Sondermeijer, Wilda Rosmolen, Wouter L. Curvers, Lorenza Alvarez Herrero, Fiebo J. ten Kate, Kausilia K. Krishnadath, Paul Fockens, Bas L. Weusten, Jacques J. Bergman Low-Grade Intra-Epithelial in Barrett's Esophagus: OverDiagnosed But Underestimated Wouter L. Curvers*, Wilda Rosmolen, Brenda Elzer, Annet Schaap, Arnoud H. van Oijen, Anton H. Naber, Kausilia K. Krishnadath, Gerrit A. Meijer, Fiebo J. ten Kate, Jacques J. Bergman

M1325

Application of Duette Multi-Band Mucosectomy for Endoluminal Resection in the United States Richard K. Wood*, Yasser M. Bhat, Gregory G. Ginsberg

M1326

Predictors and Quantitative Assessment of Incomplete Response After Radiofrequency Ablation for Dysplastic Barrett's Esophagus: Analysis of Randomized ShamControlled Clinical Trial (the AIM Dysplasia Trial) Charles J. Lightdale*, Bergein F. Overholt, Kenneth K. Wang, Hiroshi Mashimo, Virender K. Sharma, David E. Fleischer, Joseph Galanko, Nicholas J. Shaheen, Prateek Sharma

MAY 19

M1327

Dental Erosion in Patients Carrying of Gastroesophageal Reflux Esophagitis Marilene B. Alves*, Kiyoshi Hashiba, Eduardo A. Andre, Carlos A. Cappellanes, Daniel S. Vilas Boas, Esther G. Birman

M1328

Prevalence of Complicated Gastroesophageal Reflux Disease and Barrett's Esophagus Among Racial Groups in a Multi-Center Consortium Amy Wang*, Nora Mattek, David A. Lieberman, Glenn M. Eisen

M1329

Long Term Prognosis of ESD for the Superficial Esophageal Squamous Cell Carcinoma Tsuneo Oyama*, Yoko Kitamura, Kinichi Hotta

P-202

M1330

An Extracellular Matrix Scaffold for Esophageal Stricture Prevention After Circumferential EMR Kevin M. McGrath*, Alejandro Nieponice, Irfan Qureshi, Thomas Gilbert, Stephen F. Badylak

M1331

Natural History of the Esophageal Carcinoma -Prospective and Retrospective Study By Endoscopy Toshihiko Nagaya*, Yasumasa Niwa, Ryoji Miyahara, Masanao Nakamura, Yoichi Iguchi, Yoshiko Kodama, Kakunori Banno, Osamu Maeda, Takafumi Ando, Akihiro Itoh, Naoki Ohmiya, Yoshiki Hirooka, Hidemi Goto

M1332

Risk of Metachronous Multiple Intra-Esophageal Carcinomas After Endoscopic Mucosal Resection (EMR) for Esophageal Squamous Cell Carcinoma (ESCC) Yasutaka Sukawa*, Keiko Minashi, Manabu Muto, Tomonori Yano, Kazuhiro Kaneko, Atsushi Ohtsu

M1333

Predicting Submucosal Invasion for Superficial Esophageal Cancer — Magnifying Endoscopy or EUS? Frances K. Cheung*, Philip W. Chiu, Larry Lai, Yuk Tong Lee, Anthony Y. Teoh, Enders K. Ng

M1334

Endoscopic Submucosal Dissection Is a Safe and Effective Treatment for Superficial Esophageal Cancer.First Results in a Primary Hospital Naoki Ishii*, Masayo Tsukamoto, Yusuke Izuka, Katsuyuki Fukuda, Kendi Yamazaki, Yasuhisa Kumakura, Katsunori Masuda, Noriyuki Horiki, Yoshiyuki Fujita, Toshiyuki Itoh

M1335

The Use of the Schiller Test in Esophageal Mucosa for the Detection of Precursor Lesions and Superficial Carcinoma, in Head and Neck Carcinoma Maria A. Ferreira*, Ivanir M. Oliveira, Jurandir A. Dias, Fernando L. Dias, Roberto L. Carvalho

M1336

Esophageal Cancer Patients Undergoing External Beam Radiation After Placement of Self-Expandable Metal Stents (SEMS): Is There a Risk of Radiation Dose Enhancement? Yang K. Chen*, Tracey Schefter, Francis Newman

M1337

Long-Term Outcome of Esophageal Mucosal Squamous Cell Carcinoma Without Lymphovascular Involvement After Endoscopic Resection Ryu Ishihara*, Hideo Tanaka, Hiroyasu Iishi, Yoji Takeuchi, Noriya Uedo

M1338

Long-Term Outcomes of Patients with Superficial Esophageal Squamous Cell Carcinoma After Endoscopic Mucosal Resection (EMR) Daisuke Fukuda*, Keiko Minashi, Manabu Muto, Tomonori Yano, Kazuhiro Kaneko, Atsushi Ohtsu

M1339

Comparison of Endoscopic Stenting Versus Surgical Jejunostomy Tube for Maintainance of Nutrition and Dysphagia in Patients with a Malignant Esophageal Stricture Receiving Neoadjuvant Chemoradiation Ali Siddiqui*, Stuart J. Spechler

M1340

Novel Optical Imaging Techniques for Diagnosis of Esophageal Squamous Cell Carcinoma - A Prospective Case Study On Detection of Esophageal Squamous Cell Carcinomas Using NBI Compared with AFI Haruhisa Suzuki*, Yutaka Saito, Ichiro Oda, Tsuyoshi Kikuchi, Shinsuke Kiriyama, Shuusei Fukunaga

M1341

Digestive Endoscopy Investigation in Patients with Head and Neck Cancer for An Earlier Diagnosis and Treatment of the Esophagus Cancer Spencer Vaiciunas*, Rafaela d. Machado, Leomar C. Machado, José C. Ardengh, José Luiz P. Módena

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL M1342

Multiple Lugol-Voiding Lesions As a Risk Factor for a Second Primary Squamous Cell Carcinoma in Patients with Esophageal Cancer and Head and Neck Cancer Keisuke Hori*, Hiroyuki Okada, Yoshirou Kawahara, Ryuta Takenaka, Masahide Kita, Daisuke Tanioka, Takao Tsuzuki, Masahumi Inoue, Seiji Kawano, Satoru Yagi, Chiho Takekawa, Masayuki Uemura, Yasuhiro Shirakawa, Tomoki Yamatuji, Yoshio Naomoto, Shigenobu Nomiya, Tomoo Onoda, Susumu O. Tominaga, Kazuhide Yamamoto

M1354

A Study On the Endoscopic Mucosal Resection of Muscularis Mucosal Esophageal Tumor Li Xueliang*, Lin Lin, Shi Ruihua

M1355

Feasibility and Safety of Endoscopic Full Thickness Esophageal Wall Resection and Defect Closure in a Prospective Long Term Survival Animal Study Annette Fritscher-Ravens*, Amir Ghanbari, Kamini Patel, Peter Koehler, Erich Kahle, Heiner Niemann, Peter Milla

M1343

Novel Removable Internally Covered Self-Expanding Metal Esophageal Stent (SEMS): Feasibility, Technique of Removal and Tissue Response in Humans Mohamad A. Eloubeidi*, Tercio Lopes

M1356

Experimental Model for Endoscopic Stapled Diverticulotomy Fabio Y. Hondo*, José H. Giordano-Nappi, Fauze MalufFilho, Eduardo Grecco, Eduardo Guimarães H. de Moura, Ivan Cecconello, Paulo Sakai

M1344

Photodynamic Therapy in Superficial Esophageal Cancer : A Comparison Between Patients Treated in Primary Intent and Patients Treated As a Salvage Therapy After Local Failure of Chemoradiotherapy Stéphane Lecleire*, Frédéric Di Fiore, Michel Antonietti, Emmanuel Ben-Soussan, Eric Lerebours, Pierre Michel, Philippe R. Ducrotté

M1357

Gender Differences in Patients Presenting with Dysphagia Kathryn R. Byrne*, Kristen Thomas, John C. Fang, Mae F. Go, Scott H. Mackenzie, Kathryn A. Peterson

M1358

Role of Proton Pump Inhibitor As a Predisposing Factor of Candida Esophagitis ETSUO HOSHINO, Tadashi Fujisaki*, Makoto Tatewaki, Junko Fujisaki, Naoyuki Uragami, Rikiya Fujita

M1359

Long-Term Results of Endoscopic Injection Sclerotherapy for Esophageal Varices in Adults: 20-Year Prospective Evaluation Mika Yuki*, Hideaki Kazumori, Satoko Takuwa, Keiko Tateishi, Kimiko Nagasako, Hiroyuki Fukuhara, Takane Azumi, Yoshinori Komazawa, Toshihiro Shizuku

M1360

Dysphagia in Young Patients: Worth Having a Look? Nick Powell*, Thomas A. Treibel, Joel Dunn, Joel Mawdsley, Jonathan M. Hoare, Rupert Negus, Huw J. Thomas, Julian P. Teare, Timothy Orchard

M1361

Feasibility Study of a New Percutaneous Endoscopic Gastrostomy (PEG) Procedure, the “Direct Ideal PEG”, in Patients with Advanced Head and Neck Cancer or Esophageal Cancer Tomonori Yano*, Manabu Muto, Keiko Minashi, Naomi Kiyota, Takashi Kojima, Satoshi Takeuchi, Makoto Tahara, Kazuhiro Kaneko, Atsushi Ohtsu

M1362

Clinical Application of Endoscopic Balloon Dilation in Esophageal Stricture Caused By Treatment of Hypopharyngeal Cancer After Failure of Bougienage Yi-Chun Chiu

M1363

Complete Esophageal Obstruction: A Case Series of a Rare Diagnosis Requiring Innovative Treatment Eric A. Johnson*, Bret J. Spier, Vincent A. Sawma, Mark Reichelderfer

M1364

Endoscopic Removal of Oesophageal Self Expanding Metal Stents - Is It Safe and Feasible? Michael Swan*, David Devonshire, William Sievert

M1365

Endotherapy of Upper GI Anastomotic Leaks Using a Modified Tygon Plastic Stent: Results of a Large Single Center Series Stefan Seewald*, Tiing Leong Ang, Stefan Groth, Karl C. Yu Kim Teng, Michael Köpernik, Yan Zhong, Emre F. Yekebas, Jakob R. Izbicki, Frank Thonke, Nib Soehendra

M1366

Silicone-Covered Self-Expanding Polyester Stents for the Closure of Thoracic Anastomotic Leaks After Esophagectomy Satish Nagula*, Mark A. Schattner, Manjit S. Bains, Hans Gerdes

M1367

Herpes Simplex Virus Esophagitis in Immunocompetent Patients: A Case Series from Rhode Island Hospital Erich Vorlop*, Deepak Agrawal, Sripathi R. Kethu

M1345

M1346

Fully Covered Removable Nitinol Self Expandable Metal Stents (SEMS) in Benign Esophageal Diseases: A Multicenter Analysis Mohamad Eloubeidi*, Michel Kahaleh, Jayant P. Talreja, Tercio Lopes, Basil S. Al-Awabdy, Vanessa M. Shami Does Daily Alcohol and/or Cigarette Consumption Cause Low-Grade Dysplasia, a Precursor of Esophageal Squamous Cell Carcinoma? Kazuhiro Kaneko*, Tomonori Yano, Keiko Minashi, Hiroaki Ikematsu, Toshihiko Doi, Takayuki Yoshino, Nozomu Fuse, Naomi Kiyota, Takahiro Horimatsu, Etsuko Warita, Shinya Tsuruta, Yuki Asada, Daisuke Fukuda, Satoshi Mochizuki, Hiroki Hara, Atsushi Ohtsu, Atsushi Katagiri, Kazuo Konishi, Michio Imawari

M1347

Prospective Randomized Comparison Between EMR and ESD for Endoscopic Removal of Superficial Esophageal Cancer Pierre H. Deprez*, Ralph C. Yeung, Tarik Aouattah, Christine Sempoux, Hubert Piessevaux

M1348

Oesophageal Stenting for Malignancy: A UK Perspective Neil Rajoriya*, Jon Simmons, Anthony S. Mee, Michael Booth, Thomas Dehn, Jonathan Booth

M1349

Endoluminal Resection (ELR) with the Duette MultiBand Mucosectomy System Is Safe, Efficacious and Enhances Diagnosis and Staging in Highly Dysplastic Barrett's Yasser M. Bhat*, Colleen M. Brensinger, Gregory G. Ginsberg

M1350

Endoscopic Submucosal Dissection Versus Endoscopic Mucosal Resection in Management of Superficial Squamous Esophageal Neoplasms Anthony Y. Teoh*, Frances K. Cheung, Philip W. Chiu, Enders K. Ng

M1351

Analysis of Clinical Outcomes of Esophageal Stent Placement for Palliation of Malignant Dysphagia Krishdeep S. Chadha*, Michael D. Schiff, Michael D. Sitrin, Gregory E. Wilding, Hector R. Nava

M1352

Esophageal Stents for Palliation of Malignant Dysphagia Due to Extrinsic Compression E. M. Verschuur*, Ernst J. Kuipers, Peter D. Siersema

M1353

Comparison of Endoscopic Sclerosis with Endoscopic Band Ligation for Hemostasis of Active Hemorrhage Elicited By Rupture of Esophageal Varices Gustavo O. Luz, Fauze Maluf-Filho*, Sergio E. Matuguma, Fábio Y. Hondo, Spencer Cheng, Jeane M. Melo, Edson Ide, Sônia N. Fylyk, Fernanda T. Barroso, Paulo Sakai

Denotes DDW Poster of Distinction

P-203

M O N D A Y MAY 19

POSTER SESSIONS—CLINICAL M1368

Upper Gastrointestinal Symptoms and Associated Disorders in Morbidly Obese Patients - A Prospective Study Manish Arora*, Sudhir K. Dutta, Kireet Agrawal, Hany Bashandy, Alejandro Gandsas

M1369

Utility of a Fully Covered Metal Stent for the Treatment of Benign Esophageal Conditions Lincoln E. Ferreira*, Todd H. Baron, Louis-Michel Wong Kee Song

M1370

M1371

The Role of Narrow Band Imaging in the Detection of Early Esophageal Varices. Does the NBI Grade Varix Exist? Interobserver Agreement Using Narrow Band Imaging and White Light Luis F. Lara*, Shou Jiang Tang, Jayaprakash Sreenarasimhaiah, Saad F. Jazrawi, Samir Gupta, William C. Santangelo, Henrik Westergaard, William M. Lee, Don C. Rockey

M1372

Strategy for Prophylactic Patients with Risky Esophageal Varices Complicated with Hepatocellular Carcinoma Nobuhiko Nagamine

M1373

Long-Term Outcome of Endoluminal Gastroplication (ELGP) for the Treatment of Gastroesophageal Reflux Disease (GERD): The First Multicenter Trial in Japan Soji Ozawa*, Koichiro Kumai, Kazuhide Higuchi, Tetsuo Arakawa, Mototsugu Kato, Masahiro Asaka, Natsuya Katada, Hitoshi Shimao, Hiroyuki Kuwano, Masaki Kitajima

M1374

M1375

M1376

M O N D A Y

Screening for Esophageal Varices in End Stage Liver Disease: Utility of Esophageal Capsule Endoscopy Ayodele T. Osowo*, Rekha Cheruvattath, Vinodh Jeevanantham, Hugo E. Vargas, Jorge L. Rakela, Elizabeth J. Carey

M1377

MAY 19 M1378

M1379

P-204

Endoscopic Grading of Gastroesophageal Flap Valve and Atrophic Gastritis Is Helpful to Predict Gastroesophageal Reflux Gwang Ha Kim*, Jae Sup Eum, Hyoung Yoel Park, Yong Mock Bae, Eul Jo Jeong, Jae Seung Lee, Seung Keun Park, Dae Hwan Kang, Geun-Am Song Outcome of Difficult Patients with Severe Gastroesophageal Reflux Disease Treated By Endoscopic Gastroplication Shahriar Sedghi*, Leslie A. Harris Endoscopic Full-Thickness Plication for GERD: 12Month Multi-Center Study Results Using a Multiple Plication Technique Karel Caca*, Ingolf Schiefke, Karl-Hermann Fuchs, Daniel von Renteln, Michael Philipper, Wolfram Breithaupt, Horst Neuhaus Increased COX-2 Expression of Esophageal Squamous Epithelium in the Patients with Reflux Esophagitis Su Jin Hong*, Bong Min Ko, Chang Beom Ryu, Jin-Oh Kim, Joo Young Cho, Joon Seong Lee, Moon Sung Lee, Chan Sup Shim, Boo Sung Kim Histopathology of the Endoscopic Esophagogastric Junction in Patients with GERD Claudia Ringhofer*, Johannes Lenglinger, Barbara Izay, Katharina Kolarik, Johannes Zacherl, Margit Eisler, Friedrich Wrba, Parakrama Chandrasoma, Gerhard Prager, Martin Riegler Effects of Endoscopic Full-Thickness Plication On GERD Measured By Multichannel Intraluminal Impedance Monitoring Daniel von Renteln*, Bettina Riecken, Ulrike Brey, Arthur Schmidt, Gabor Kalmar, Karel Caca

M1380

Esophagitis: Analysis of Immunohistochemical Expression of the p53 Protein and Ki67 (Mib1) Antigen in the Squamous Epithelium of the Esophagus in Patients with GERD and Chronic Esophagitis Marcelo Binato, Renato B. Fagundes, Luise Meurer, Maria Isabel A. Edelweiss, Richard R. Gurski*

M1381

Impact of Age On Symptoms of Gastroesophageal Reflux Disease Krishna Pondugula*, Ajay Bansal, Sachin B. Wani, Sandy B. Hall, Amit Rastogi, Prateek Sharma

M1382

The Prevalence of Erosive Esophagitis Among Patients Taking Low-Dose Aspirin in Japan Takatsugu Yamamoto*, Shin Nakayama, Kunitaka Nagasawa, Yukako Osaki, Hiroko Tsutsumi, Koichiro Abe, Hajime Anjiki, Kengo Hattori, Masaki Sanaka, Taro Ishii, Yasushi Kuyama

M1383

The Effect of Pantoprazole Versus Placebo On Gastroesophageal Reflux Disease (GERD) Related Symptoms Other Than Heartburn Ronnie Fass*, Gordana Bothe, Hartmut Heinze, Hubert Monnikes

M1384

Risk Factor of Erosive Esophagitis for Adults with Normal Z-Line in Korea Sung Woo Jung*, Sang Woo Lee, Sun Min Park, Ik Yoon, Jin Nam Kim, Dong Il Kim, Ja Seol Koo, Hyung Joon Yim, Jong-Jae Park, Hoon Jai Chun, Hong Sik Lee, Jai Hyun Choi, Chang Duck Kim, Ho Sang Ryu

M1385

Characteristics of 24 Hour Multiple Channel Intraluminal pH-Impedance Reflux Testing (MII-pH) Following Endolumenal Antireflux Therapy Anthony A. Starpoli, David L. Ulrich*, Ramani Rangavajhula, Vasco Eguia

M1386

A Prospective Randomized Trial of Sham, Single Dose Stretta and Double Dose Stretta for the Treatment of Gastroesophageal Reflux Disease (GERD): One Year Follow-Up Ayman M. Abdel Aziz*, Hisham El-Khayat, Ahmed Sadek, Samer G. Mattar, Gail McNulty, Glen A. Lehman

ASGE Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

EUS M1387

Should Endoscopic Ultrasound (EUS) Be a Mandatory Component of the Pre Treatment Staging of All Newly Diagnosed Rectal Cancers? A Prospective Study Roman Galysh*, Charles M. Friel, Eugene F. Foley, Patrick G. Northup, Grace E. White, Alfredo J. Hernandez, Michel Kahaleh, Vanessa M. Shami

M1388

Validation of ASGE Quality Metrics in EUS: Association with Clinical Outcomes Patrick W. Cleveland*, Susan G. Coe, Timothy A. Woodward, Massimo Raimondo, Laith H. Jamil, Kanwar R. Gill, Seth A. Gross, Michael G. Heckman, Julia Crook, Michael B. Wallace

M1389

Prognostic Value of the Pretherapeutic EUS Staging in Rectal Cancer Treated By Radio-(Chemo)Therapy Followed By Surgery. Long Term Results of the FFCD 9203 Randomized Study Pascal Burtin*, Nicolas Methy, Jean-Pierre Gérard, Thierry Conroy, Olivier Bouché, Olivier Chapet, Franck Bonnetain

M1390

Is It Useful to Reassess Patients with Rectal Endoscopic Ultrasound After Preoperative Radiotherapy for Rectal Cancer? Long Term Results in a Randomized Trial Pascal Burtin*, Nicolas Methy, Jean-Pierre Gérard, Olivier Bouché, Thierry Conroy, Olivier Chapet, Franck Bonnetain

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL M1391

Rectal Endoscopic Utrasound Versus Pelvic Magnetic Resonance for Perianal Fistula: A Meta-Analysis and Systematic Review Justin W. Case, Houssam E. Mardini*, Nicholas J. Nickl, Alla Grigorian, Willem J. de Villiers

M1392

Value of High-Frequency Miniprobes and Conventional Radial Endoscopic Ultrasound in the Staging of Early Barrett's Carcinoma: A Prospective Randomized Trial with a Cross-Over Design Oliver Pech*, Erwin Guenter, Frank Dusemund, Hendrik Manner, Christian Ell

M1393

M1394

M1395

M1396

The “True False Positive” Rate: Correlation of EUS FNA Findings in Patients Undergoing Direct Surgical Intervention Ferga C. Gleeson*, Amy C. Clayton, Kevin C. Halling, Benjamin R. Kipp, Jill L. Caudill, Jonathan E. Clain, Elizabeth Rajan, Mark D. Topazian, Kenneth K. Wang, Maurits J. Wiersema, Michael J. Levy Accuracy of Endoscopic Ultrasound in Preoperative Staging of Esophageal Cancer in a Tertiary Care Center Oliver Pech*, Frank Dusemund, Erwin Guenter, Judith Origer, Hendrik Manner, Dietmar Lorenz, Christian Ell In Patients with Barrett's Esophagus (BE) and High Grade Dysplasia (HGD), Does Endoscopic Ultrasound (EUS) Provide Additional Information Beyond Esophagogastroduodenoscopy (EGD) Alone? Charles S. Whang*, Christopher E. Lee, Thomas Thong H. Nguyen, John G. Lee, Kenneth J. Chang, V. Raman Muthusamy Assessment of Response to Neoadjuvant Therapy in Esophageal Cancer - A Systematic Review of Diagnostic Accuracy of Endosonography (EUS) and Fluorine 18Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) Saowanee Ngamruengphong*, Ananya Das, Virender K. Sharma

M1397

Variation in Barrett's Esophageal Wall Thickness: Is It Associated with Histology or Segment Length? Kanwar R. Gill*, Irfan Nawaz, Julia Crook, Seth A. Gross, Marwan S. Ghabril, Laith H. Jamil, Timothy A. Woodward, Michael B. Wallace, Massimo Raimondo, Sami R. Achem, Chakri Panjala, Herbert C. Wolfsen

M1398

First Experience with a New Double Channel Linear Array Echoendoscope for Advanced Interventional EUS Procedures Compared to a Single Lumen Instrument in a Long-Term Animal Survival Study Annette Fritscher-Ravens*, Amir Ghanbari, Axel von Herbay, Erich Kahle, Peter Koehler, Heiner Niemann, Kamini Patel

M1399

EUS in the Evaluation of the Patients Performed Endoscopic Submucosal Dissection Jin-Oh Kim, Hyun Gun Kim*, Joo Young Cho, Young Koog Cheon, Young Deok Cho, Jong Ho Moon, Joon Seong Lee, Moon Sung Lee, Chan Sup Shim

M1400

The Use of Contrast Enhanced Endoscopic Ultrasound in Discrimination Between Focal Pancreatitis and Pancreatic Cancer Michael Hocke*, Christoph F. Dietrich, Andreas Stallmach

M1401

Prospective, Randomized Comparison of Mechanical and Electronic Endoscopic Ultrasound Systems: Image Quality and Performance Parameters - Final Results Ioannis S. Papanikolaou*, Andreas Adler, Eumorphia M. Delicha, Katharina Wegener, Eleftheria Giannakoulopoulou, Bertram Wiedenmann, Thomas Roesch

M1402

Endoscopic Ultrasound Elastography for the Upper Gastrointestinal Tract Disease Ryoji Miyahara*, Yasumasa Niwa, Masanao Nakamura, Yoichi Iguchi, Yoshiko Kodama, Kakunori Banno, Osamu Maeda, Takafumi Ando, Akihiro Itoh, Naoki Ohmiya, Yoshiki Hirooka, Hidemi Goto

M1403

EUS-Guided Fiducial Placement for Stereotactic Radiosurgery in Pancreatic Cancer Michael K. Sanders*, Asif Khalid, Kenneth E. Fasanella, Herbert Zeh, Arthur J. Moser, Steven A. Burton, Kevin M. McGrath

M1404

Enhancing Accuracy of Endoscopic Ultrasonography (EUS) with Sonovue and a Dedicated Contrast Harmonic Echo (CHE): A Preliminary Experience Pietro Fusaroli*, Franca Patrizi, Antonino Grillo, Giancarlo G. Caletti

M1405

Intraductal Ultrasound in Evaluation of Indeterminate Pancreaticobiliary Strictures: A 50 Patient Experience Ashwin P. Ashok*, Sonya Reicher, David S. Chung, Binh V. Pham, Viktor E. Eysselein

M1406

Contrast-Enhanced Endoscopic Ultrasonography (CEEUS) in Solid Tumors of the Pancreas: Results of a Pilot Study Bertrand Napoleon*, Rodica Gincoul, Christine Lefort, Bertrand Pujol, Jean-Christophe Souquet, Pierre-Edouard Queneau, Thierry Ponchon

M1407

Single-Scope EUS Guided Cyst Access, Debridement and Drainage Using a Novel Therapeutic Forward Viewing Echoendoscope Tonya R. Kaltenbach*, Mark A. De Lusong, Roy M. Soetikno, Janak N. Shah, Kenneth F. Binmoeller

M1408

EUS-Guided Fiducial Placement (EUS FNF) Prior to Targeted Radiation Therapy in Abdominal and Pelvic Tumors: A Case Series Julie Yang*, Amar R. Deshpande, Daniel A. Sussman, May Abdel-Wahab, B-Chen Wen, Afonso C. Ribeiro

M1409

A Prospective Randomised Crossover Comparison of Standard and High Negative Pressure Suction Techniques for EUS-FNA Vu Kwan*, Pierre Eisendrath, Jean-Luc van Laethem, Pieter Demetter, Nathalie Nagy, Jacques M. Deviere

M1410

Effectiveness of EUS-FNA for Suspected Recurrence of Lymphadenopathy After Radical Treatment of Malignancy Takuji Iwashita*, Ichiro Yasuda, Masanori Nakashima, Shinpei Doi, Hisataka Moriwaki

M1411

Transgastric and Trans-Duodenal Endoscopic Ultrasound-Guided Fine Needle Aspiration of the Left and Right Adrenal Glands Katherine R. Black, Ashutosh Tamhane, Mohamad A. Eloubeidi*

M1412

Cost Efficacy of Endoscopic Ultrasound and Endobronchial Ultrasound with Fine Needle Aspiration (EUS-FNA+EBUS-FNA) Versus Mediastinoscopy for the Staging of Patients with Non Small Cell Lung Cancer (NSCLC) and Abnormal Mediastinal Lymph Nodes By Non-Invasive Imaging Stacie A. Vela*, Kit N. Simpson, Marcelo F. Vela, Gerard A. Silvestri, Carolyn E. Reed, Brenda Hoffman

M1413

High Frequency of Intrabdominal Lung Cancer Metastases Justifies EUS As Test of Choice in a Specific Patient Subset: An Evidence-Based Staging Algorithm Kirk Bernadino*, Madeline S. Pokorney, John Streitz, John Deutsch

Denotes DDW Poster of Distinction

P-205

M O N D A Y MAY 19

POSTER SESSIONS—CLINICAL M1414

The Learning Curve (or Slide) for Endobronchial Ultrasound-FNA By Pulmonologists After Training By Experts in Endoscopic Ultrasound Anas Iguaddouren*, Jorge M. Pascual, Margaret M. Johnson, Michael G. Heckman, Julia Crook, Timothy A. Woodward, Massimo Raimondo, Laith H. Jamil, Kanwar R. Gill, Seth A. Gross, Michael B. Wallace

M1415

The Role of EUS FNA for Pancreatic Metastases: Diagnostic Accuracy, Tumor Appearance, Incremental Utility Versus Computed Tomography, and Impact On Patient Care Michael J. Levy*, Todd H. Baron, Joshua G. Barton, Suresh T. Chari, Jonathan E. Clain, Michael B. Farnell, Randall K. Pearson, Bret T. Petersen, Elizabeth Rajan, Mark D. Topazian, Santhi Swaroop Vege, Maurits J. Wiersema, Michael L. Kendrick

M1416

M1417

M1418

A Prospective Randomized Study Comparing Endoscopic Ultrasound Guided Trucut Biopsy and Fine-Needle Aspiration with High Suction for Histologic Yield and Diagnostic Accuracy Maged K. Rizk*, Andrew D. Vanderheyden, Chris S. Jensen, Henning Gerke Prospective Cytologic Assessment of Gastrointestinal Luminal Fluid Acquired During EUS: Potential Source of False Positive FNA and Needle Tract Seeding Michael J. Levy*, Michael B. Campion, Jill L. Caudill, Jonathan E. Clain, Ferga C. Gleeson, Kevin C. Halling, Elizabeth Rajan, Mark D. Topazian, Kenneth K. Wang, Maurits J. Wiersema, Amy C. Clayton Trans-Duodenal Sampling of the Right Adrenal Gland: A Novel Approach and a New Indication for EUS-Guided FNA Mohamad A. Eloubeidi*, Desiree E. Morgan, Robert J. Cerfolio, Isam A. Eltoum

M1419

Endoscopic Ultrasound Surveillance of Submucosal Tumors: Results of a Single Center Experience Houssam E. Mardini*, Stephanie Murphy, Alla Grigorian, Nicholas J. Nickl

M1420

Utility of a Miniprobe EUS On Planning of Treatment for Early Colon Cancer Jin Gook Huh, You Sun Kim*, Won Cheol Jang, Kyung Sun Ok, Tae Yeob Jeong, Soo Hyung Rye, Jung Hwan Lee, Jeong Seop Moon, Hye Kyung Lee

M O N D A Y

M1421

The Natural History of Upper Gastrointestinal Subepithelial Tumors (SETS): A Multicenter Endoscopic Ultrasound (EUS) Survey Kanwar R. Gill*, Lorenzo Camellini, Rita Conigliaro, Romano Sassatelli, Francesco Azzolini, Timothy A. Woodward, Laith H. Jamil, Michael B. Wallace, Massimo Raimondo

MAY 19

M1422

M1423

M1424

P-206

Quality in Endoscopic Ultrasonography: An Assessment of Baseline Compliance and Performance Improvement Using the ASGE-ACG Quality Indicators Susan G. Coe*, Massimo Raimondo, Timothy A. Woodward, Michael G. Heckman, Julia Crook, Kanwar R. Gill, Laith H. Jamil, Michael B. Wallace Trans-Esophageal EUS-Guided Fine Needle Aspiration or Core Biopsy Is Useful for Differential Diagnosis of Granulomatous Diseases in Undetermined Mediastinal Lesions Ho June Song*, Se Jin Jang, Dong Wan Seo, Sang Soo Lee, Kee Don Choi, Gin Hyug Lee, Hwoon-Yong Jung, Jin-Ho Kim

M1425

Can Endoscopic Ultrasound Predict If Rectal Cancers or Large Polyps Can Be Resected Endoscopically? A MetaAnalysis and Systematic Review Srinivas R. Puli*, Jyotsna BK Reddy, Matthew L. Bechtold, Praveen K. Roy, Jack D. Bragg, Priya D. Ravindran, Jamal A. Ibdah, Mainor R. Antillon

M1426

Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Suspected Mesenchymal Tumors of the Gastrointestinal Tract: Correlation with Surgical Pathology Jillian M. O'Neil*, Mohammad A. Al-Haddad, Julia K. LeBlanc, Lee McHenry, Stuart Sherman, John DeWitt

M1427

The Usefulness of IDUS-Guided Transpapillary Bile Duct Biopsy for the Diagnosis of Malignant Biliary Strictures Jong Ho Moon*, Hyun Jong Choi, Hee Kyung Kim, Kye Won Kwon, Young Koog Cheon, Young Deok Cho, Joon Seong Lee, Moon Sung Lee, Hae Kyung Lee, Chan Sup Shim

M1428

New EUS Variable of Central Hypoechoic Foci Is a Strong Predictive Factor for Differential Diagnosis Between Neoplastic and Nonneoplastic Gallbladder Polyps Jae Hee Cho*, Jeong Youp Park, Sung Pil Hong, Seung Woo Park, Si Young Song, Jae Bock Chung, Seungmin Bang

M1429

Diagnosis of Chronic Pancreatitis (CP) By Endoscopic Ultrasound (EUS) - Radial vs. Linear Endosonography (EUS) Marc F. Catalano*, Vivek Kaul, Lyndon V. Hernandez, Jonathan P. Pezanoski, Nalini M. Guda, Dhanasekaran Ramasamy, Ramanujan Samavedy, Joseph E. Geenen

M1430

Chemosensitivity Test to Predict Chemosensitivity for Gemcitabine, Using the Biopsy Speciemens Obtained By EUS-FNA from Unresectable Pancreatic Carcinoma Takeru Wakatsuki*, Atsushi Irisawa, Goro Shibukawa, Tadayuki Takagi, Hidemichi Imamura, Ai Sato, Masaki Sato, Tsunehiko Ikeda, Rei Suzuki, Takuto Hikichi, Katsutoshi Obara, Hiromasa Ohira

M1431

Pancreatic Cancer Screening in a High-Risk Population: Preliminary Data of a Multi-Center Trial Employing Carbohydrate Antigen (CA) 19-9 and Endoscopic Ultrasound Richard Zubarik*, Stuart R. Gordon, Eric K. Ganguly, Virginia L. Kelly, James A. Vecchio, Steven Lidofsky

M1432

Usefulness of Contrast-Enhanced Endoscopic Ultrasonography (CE-EUS) in the Diagnosis of Mural Nodule of Intraductal Papillary Mucinous Neoplasms of the Pancreas. the Comparison of the CE-EUS Findings with the Pathological Findings Eizaburo Ohno*, Yoshiki Hirooka, Akihiro Itoh, Hiroki Kawashima, Kazuo Hara, Koji Nonogaki, Toshifumi Kasugai, Takuya Ishikawa, Naoki Ohmiya, Yasumasa Niwa, Hidemi Goto

M1433

Comparison of CEA and DNA Analysis in 100 Consecutive Patients with Pancreatic Cysts Mandeep S. Sawhney*, Shiva Devarajan, Richard P. O'Farrell, Marcelo S. Cury, Rabi Kundu, Girish Anand, Hani Y. Abdallah, Siwar Albashir, Charles M. Vollmer, Alphonso Brown, Ram Chuttani, Douglas Pleskow

M1434

T-Staging of Ampullary Tumor By Endoscopic Ultrasound Before Endoscopic Ampullectomy: How Reliable Is It? Nam Q. Nguyen*, Kenneth F. Binmoeller

Detection of Celiac Ganglia with Radial Scanning EUS Gwang Ha Kim*, Tae In Ha, Hye-jeong Lee, Il Du Kim, Sun Mi Lee, Jeong Heo, Dae Hwan Kang, Geun-Am Song, Mong Cho

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL M1435

M1436

M1437

M1438

Prospective Comparison of Radial and Linear Endoscopic Ultrasound (EUS) for the Diagnosis of Chronic Pancreatitis (CP) Using Secretin Pancreatic Function Test (PFT) As Reference Standard Tyler Stevens*, John J. Vargo, Gregory Zuccaro, John A. Dumot, Mansour A. Parsi, Bret Lashner, Rocio Lopez, Edward D. Purich, Darwin Conwell EUS-Guided Celiac Plexus Neurolysis vs. Block: Assessing Interference with Pancreatic Surgery and Adhesions in a Pig Survival Model Vasu Appalaneni, Katherine A. Morgan, Robert H. Hawes, Brenda Hoffman, Joseph Romagnuolo* Endoscopic Ultrasound Fine Needle Aspiration (EUSFNA) with or Without Flow Cytometry (± FC) for the Diagnosis of Primary Pancreatic Lymphoma: A Single Center Experience Mohammad A. Al-Haddad*, John DeWitt, Julia K. LeBlanc, Lee McHenry, Mouen Khashab, Jillian M. O'Neil, Mojgan S. Savabi, Stuart Sherman Preliminary Results of a Randomized, Double Blind, Controlled Trial of Early EUS-Guided Celiac Plexus Neurolysis (EUS-CPN) Versus Conventional Management for Pain in Patients with Inoperable Pancreatic Cancer Mariana Usatii, Sarto C. Paquin, Michel Dagenais, Real Lapointe, Richard Letourneau, Marylene Plasse, Andre Roy, Franck Vandenbroucke, Anand Sahai*

M1439

Diagnostic Yield and Safety of Cyst Wall Puncture During EUS-Guided Fine Needle Aspiration of Pancreatic Cystic Lesions Bheema S. Singu*, David E. Loren, Thomas E. Kowalski

M1440

The Value of Endosonography to Predict Symptomatic Stenosis of the Pancreatic Sphincter Nittly Chahal-Sekhon*, Viktor E. Eysselein, David S. Chung

M1441

Awareness of International Consensus Guidelines for the Management of Intraductal Papillary Mucinous Neoplasms (IPMN) and Mucinous Cystic Neoplasms (MCN) and Impact of Guidelines On Current Practice Nonthalee Pausawasdi*, James M. Scheiman, Michelle A. Anderson

M1442

M1443

Sensitivity of EUS-Guided Biopsy of Malignant Pancreatic Solid Masses in Biopsy-Naïve Vs Rescue Patients Amar R. Deshpande*, Deborah Szabo, Caio Rocha-Lima, Joe U. Levi, Parvin Ganjei-Azar, Merce Jorda, Afonso C. Ribeiro Usefulness of the Characterization of Tissue Hardness of Pancreatic Mass Using Elastography Endoscopic Ultrasound. -First Trial of the Quantification Using Strain RatioItokawa Fumihide*, Takao Itoi, Fuminori Moriyasu, Atsushi Sofuni, Toshio Kurihara, Kentarou Ishii, Syuujirou Tsuji, Nobuhito Ikeuchi, Takashi Kawai

M1444

EUS for Choledocholithiasis: Accuracy and Cost Benefit Analysis Tarun Gupta*, Sheikh Anwar Abdullah, Steven Mesenas

M1445

Lymphoepithelial Cysts of the Pancreas: An EUS Case Series John Y. Nasr*, Michael K. Sanders, Kenneth E. Fasanella, Asif Khalid, Kevin M. McGrath

M1446

Restaging and Assessment of Resectability of Locally Advanced Pancreatic Cancer By EUS After Neoadjuvant Therapy Jon Walker*, Uzair Chaudhary, Esnaola F. Nestor, Joseph Romagnuolo, Robert H. Hawes, Brenda Hoffman

M1447

Temporal Trend in Utilization of Endoscopic Ultrasonography in Patients with Pancreatic Cancer Feng Li*, Ying Zhou, Amitabh Chak, Gregory S. Cooper, Ananya Das

M1448

Ultrasonographic Differential Diagnosis of Gallbladder Polyps Julia Orlova*, Elena Bystrovskaya, Anatoly Ilchenko, Sergej G. Khomeriki

M1449

Diagnostic Accuracy of EUS/EUS-FNA for Pancreatic Cancer in Patients with or Without Associated Chronic Pancreatitis Banke Agarwal*, Amith V. Reddy, Jennifer L. Labundy, Naveen B. Krishna

M1450

Clinical Significance of Dilated Common Bile Duct and Pancreatic Duct in Patients with or Without Obstructive Jaundice Banke Agarwal*, Amith V. Reddy, Jennifer L. Labundy, Naveen B. Krishna

M1451

Size of Pancreatic Cysts Strongly Influences the Diagnostic Yield of EUS-FNA Neal J. Schamberg*, Ketan Kulkarni, Roberto R. Gonzalez, Paul J. Christos, Savreet Sarkaria, Mark Pochapin, Felice Schnoll-Sussman

M1452

Utility of Contrast-Enhanced Endoscopic Ultrasonography (CE-EUS) in the Diagnosis of Pancreatic Diseases Using Perflubutane Microbubbles Yoshiki Hirooka*, Akihiro Itoh, Hiroki Kawashima, Kazuo Hara, Koji Nonogaki, Toshifumi Kasugai, Eizaburo Ohno, Takuya Ishikawa, Naoki Ohmiya, Yasumasa Niwa, Hidemi Goto

M1453

Endoscopic Ultrasound in Patients with a Dilated Common Bile Duct, Essentially Normal Liver Function Tests, and Negative Cross-Sectional Imaging Nathalie Saheb*, Dev S. Segarajasingam, Briohny Smith, Hooi C. Ee, Ian F. Yusoff

M1454

Fluid CEA Level Is More Influential Than DNA Mutational Analysis in Guiding Clinical Management of Pancreatic Cystic Lesions Eugene Zolotarevsky*, Richard S. Kwon, Grace H. Elta, Cyrus R. Piraka, Erik-Jan Wamsteker, James M. Scheiman, Diane M. Simeone, Michelle A. Anderson

M1455

Role of Endoscopic Ultrasonography in Exploring the Etiology of Acute Biliary Pancreatitis with Negative MRCP Results Xianbao Zhan*, Zhaoshen Li, Zhendong Jin, Duowu Zou, Jie Chen

M1456

Yield of EUS and Clinical Factors in Clarifying Pancreatic Head “Fullness” Reported On Cross-Sectional Imaging Jon Walker*, Brenda Hoffman, Joseph Romagnuolo

M1457

EUS Diagnosis of Chronic Pancreatitis (CP): Comparison of the Current Criteria Vs the New “Rosemont Criteria” Developed By An International Consensus Conference Marc F. Catalano*, Lyndon V. Hernandez, Vivek Kaul, Nalini M. Guda, Jonathan P. Pezanoski, Dhanasekaran Ramasamy, Ramanujan Samavedy, Joseph E. Geenen

M1458

Evaluating the Head of the Pancreas in the Overall EUS Assessment of Chronic Pancreatitis (CP) Significantly Impacts the Overall Diagnosis Marc F. Catalano*, Vivek Kaul, Lyndon V. Hernandez, Jonathan P. Pezanoski, Nalini M. Guda, Dhanasekaran Ramasamy, Ramanujan Samavedy, Joseph E. Geenen

Denotes DDW Poster of Distinction

P-207

M O N D A Y MAY 19

POSTER SESSIONS—CLINICAL M1459

Inter-Observer Agreement Among Expert Endosonographers On EUS Features of Chronic Pancreatitis Lyndon V. Hernandez*, Marc F. Catalano

M1460

Feasibility of Quantitative Dilution of Pancreatic Cyst Fluid Obtained By EUS Stavros N. Stavropoulos*, Biju Abraham, James H. Grendell

M1461

M1462

M1463

M1464

M1465

M1466

M1467

M O N D A Y MAY 19

M1468

M1469

M1470

M1471

P-208

M1472

Endosonographic Abnormalities of Pancreas: AgeRelated Changes or Not? Maria C. Petrone*, Paolo G. Arcidiacono, Cinzia Boemo, Alessandro Ambrosi, Silvia Carrara, Gianni Mezzi, Pier A. Testoni

M1473

A Prospective Comparison of Endoscopic Ultrasound Versus MRI for Staging of Pancreatic Cancer Michelle Loch*, Michel Kahaleh, Alejandro C. Stella, Patrick G. Northup, Grace E. White, Andrew S. Brock, Vanessa M. Shami

M1474

Predicting Resolution of Pancreatic Pseudocysts After EUS-Guided Therapy or Surgical Drainage Jayaprakash Sreenarasimhaiah, Saad F. Jazrawi*, Luis F. Lara, Shou Jiang Tang

M1475

Predictors of Cytological Adequacy in EUS Guided Fine Needle Aspiration of Pancreatic Tumors and Lymph Nodes Patrick W. Cleveland*, Susan G. Coe, Timothy A. Woodward, Massimo Raimondo, Laith H. Jamil, Kanwar R. Gill, Seth A. Gross, Michael G. Heckman, Julia Crook, Michael B. Wallace

M1476

EUS Can Diagnose Biliary Strictures Undetected By CT Scanning Yasuyuki Saifuku*, Michiko Yamagata, Kazunari Kanke, Genyo Hitomi, Motoo Ishida, Hironori Masuyama, Keiichi Kubota, Akira Terano, Hideyuki Hiraishi

Diagnostic Accuracy of Endoscopic Ultrasonography Compared with Multi-Detector Row Computerized Tomography in Staging of Early Gastric Cancer Hyoun Woo Kang*, Sang Gyun Kim, Hae Yeon Kang, Jong Pil Im, Joo Sung Kim, Han-Kwang Yang, Se Hyung Kim, Woo Ho Kim, Kook Lae Lee, Ji Won Kim, Hyun Chae Jung, In Sung Song

M1477

Does Endoscopic Ultrasonography Influence the Management of Patients with Acute Pancreatitis? Shinji Okaniwa*, Yoshiyuki Nakamura, Manabu Hiraguri, Naoto Horigome, Gengo Kaneko, Yuuko Okaniwa, Nobuo Itoh

Endoscopic Submucosal Dissection (ESD) of Early Gastric Neoplasia - Is Endoscopic Ultrasound (EUS) Reliable for Pretherapeutic Staging Stefan K. Goelder*, Jürgen Barnert, Gertrud Jechart, Helmut Messmann, Andreas Probst

M1478

Endoscopic Ultrasound Morphology Features and Initial Detection of Metastatic Liver Lesions from Primary Pancreatic Adenocarcinoma and Pancreatic Neuroendocrine Carcinoma Jillian M. O'Neil*, Mohammad A. Al-Haddad, Julia K. LeBlanc, Lee McHenry, Stuart Sherman, John DeWitt

Improving EUS Documentation Using Standard Text and Image Parameters Lyndon V. Hernandez*, Anand Sahai, Manoop S. Bhutani, Mohamad Eloubeidi, Frank G. Gress, James M. Scheiman, John DeWitt, Cuong C. Nguyen, Charles J. Lightdale, Massimo Raimondo, Nalini M. Guda, Marc F. Catalano

M1479

T Staging Accuracy of Endoscopic Ultrasound in Gastric Cardia Cancers: A Meta-Analysis and Systematic Review Srinivas R. Puli*, Jyotsna BK Reddy, Matthew L. Bechtold, Mainor R. Antillon, Jamal A. Ibdah

M1480

Clinical Utility of Endoscopic Ultrasound-Guided Fine Needle Aspiration in Pancreatic Masses Using a 25Gauge Needle System: A Multicenter Experience Rohit Jindal*, Adam J. Goodman, Tony E. Yusuf, Darren A. Pavey, Hazar Michael, Frank G. Gress

Prospective Comparison of Endoscopic UltrasoundGuided Fine Needle Aspiration (EUS-FNA) and Surgical Histology in Upper Gastrointestinal Submucosal Tumors Michael Philipper*, Stephan H. Hollerbach, Helmut E. Gabbert, Natalia Pomjanski, Alfred Böcking, Horst Neuhaus, Brigitte Schumacher

M1481

Variables Affecting the Accuracy of EUS-Guided FNA in the Diagnosis of Focal Pancreatic Masses Edward W. Holt*, Eric A. Macklin, William R. Brugge

Value of Dilation in the EUS Staging of Obstructing Esophageal Cancer Adrian N. Holm*, Henning Gerke

M1482

Yield of Endoscopic Ultrasound Guided Fine Needle Aspiration (EUS-FNA) in Diagnosing Submucosal Lesions of the Upper GI Tract Chris M. Hamerski, Amandeep K. Shergill, Mark Anthony A. De Lusong, Kenneth F. Binmoeller, Roy M. Soetikno, Lygia Stewart, Janak N. Shah*

M1483

EUS-Guided Ethanol Lavage with Paclitaxel Injection (EUS-EP) for Cystic Tumors of the Pancreas : Follow-Up Study with Analysis of Response and Its Predictor Hyoung-Chul Oh*, Dong Wan Seo, Sang Soo Lee, Sung Koo Lee, Myung-Hwan Kim

New EUS Criteria of Chronic Pancreatitis: Is EUS OverDiagnosing Chronic Pancreatitis? Ai Sato*, Atsushi Irisawa, Takuto Hikichi, Goro Shibukawa, Tadayuki Takagi, Takeru Wakatsuki, Hidemichi Imamura, Yuta Takahashi, Masaki Sato, Tsunehiko Ikeda, Rei Suzuki, Hiromasa Ohira Suspected Common Bile Duct Stones (CBDS) Diagnostic Evaluation and Therapeutic Procedure with EUS-ERCP One Step Anna Maria Polifemo*, Carlo Fabbri, Constance Mwangemi, Lorenzo Fuccio, Sandro Macchia, Antonella Maimone, Vincenzo Cennamo, Stefania Ghersi, Francesco Ferrara, Paola Billi, Nicola D'Imperio Use of Molecular Markers in Clinically Low Risk Cystic Lesions of the Pancreas Tamas A. Gonda*, Shashin Shah, Stavros N. Stavropoulos, Charles J. Lightdale, Peter D. Stevens

EUS and ERCP for Obstructing Pancreatic Head Masses, Should They Be Combined or Separate Procedures? Juan D. Estrada*, Uzma D. Siddiqui, Mark D. Topazian, Federico T. Rossi, Priya A. Jamidar, Lawrence S. Rosenthal, Harry R. Aslanian

Does Early Needle Exchange in EUS-FNA Improve the Diagnostic Yield of Cytopathological Evaluation in Pancreatic Adenocarcinoma? Preliminary Results from An Ongoing Randomized Trial Alberto Herreros de Tejada*, Jennifer S. Chennat, Barbara M. Cislo, Jeffrey Mueller, Shang P. Lin, Lynne Stearns, Irving Waxman Analysis of Complications After EUS-FNA in Patients with Obstructive Jaundice and Drained with Plastic Biliary Stents or Self-Expandable Metal Stents (SEMS): Do Complications Differ On the Type of Stent? Katie Rude, Michel Kahaleh, Grace E. White, Vanessa M. Shami*

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL M1484

M1485

Preliminary Study On EUS Guided Oncolytic Adenovirus Implantation in Patients of Advanced Pancreatic Cancer Qi Zhu*, Kai Xu, Lu Xia, Jihong Tan, Huifang Xiong, Yiping He, Xi Chen, Hui Fu Indications, Diagnostic Yield and Complications of Endoscopic Ultrasound Guided Trucut Biopsy (EUSTCB): Prospective Study in 77 Consecutive Patients At a Tertiary Hospital with On-Site Cytology Support John DeWitt*, Mohammad A. Al-Haddad, Lee McHenry, Julia K. LeBlanc, Kathleen A. McGreevy, Stuart Sherman

M1486

EUS Guided Fiducial Placement for Cyberknife Treatment of Pancreatic Cancer Siwar Albashir, Mandeep S. Sawhney*, Douglas Pleskow, Ram Chuttani, James C. Ellsmere, Richard P. O'Farrell, Rabi Kundu, Salvatore LaRosa, Anand Mahadevan

M1487

Initial Experience with Endoscopic Ultrasound Guided Tru-Cut Biopsy for Known or Suspected Benign Liver Disease John DeWitt*, Kathleen A. McGreevy, Oscar Cummings, Stuart Sherman, Julia K. LeBlanc, Lee McHenry, Mohammad A. Al-Haddad, Naga P. Chalasani

M1488

“A Prospective Randomized Trial of 1 Versus 2 Injections During a Single EUS-Guided Celiac Plexus Block (CPB) Procedure for Chronic Pancreatitis Pain: Final Results” Julia K. LeBlanc*, John DeWitt, Cindy Calley, Michelle Symms, Kathleen A. McGreevy, Lee McHenry, Mohammad A. Al-Haddad, Stuart Sherman, Pradermchai Kongkam, Thomas F. Imperiale

M1489

Interventional EUS-Guided Cholangiography (Ieuc): Long Term Experience of An Emerging Alternative to Percutaneous Transhepatic Cholangiography (PTC) Jennifer L. Maranki*, Vanessa M. Shami, Alfredo J. Hernandez, Michel Kahaleh

M1490

Preoperative Detection of Familial Pancreatic Neoplasms By Endoscopic Ultrasonography (EUS), Multidetector Computed Tomography (CT), and/or Magnetic Resonance Cholangiopancreatography (MRCP) Marcia I. Canto*, Richard D. Schulick, Michael G. Goggins, Charles J. Yeo, John L. Cameron, Elliot K. Fishman, Ihab R. Kamel, Ralph H. Hruban

M1491

M1492

Comparison of EUS-Guided One-Step Transmural Drainage of Pancreatic Pseudocysts and Conventional Transmural Drainage: A Prospective, Non-Blinded, Single Center, Randomized Study Sung-Hoon Moon*, Sang Soo Lee, Do Hyun Park, Sun Young Choi, Ji Young Kim, Seok Won Jung, Dong Wan Seo, Sung Koo Lee, Myung-Hwan Kim EUS Guided Gold Fiducial Insertion for Image Guided Radiation Therapy of Pancreatic Cancer Brian M. Yan*, Devin Schellenberg, Albert C. Koong, Jacques Van Dam

M1493

Graded Dilation Technique for EUS-Guided Drainage of Peripancreatic Fluid Collections: An Assessment of Outcomes, Complications and Learning Curve Shyam Varadarajulu*, Ashutosh Tamhane, Jeanetta Blakely

M1494

EUS-Guided Drainage: An Alternative to Surgical and Percutaneous Approaches for Management of Multiple, Non-Communicating Peripancreatic Fluid Collections Shyam Varadarajulu*, Jeanetta Blakely

M1495

EUS Versus Surgical Cyst-Gastrostomy for Management of Pancreatic Pseudocysts Shyam Varadarajulu*, Tercio Lopes, Charles M. Wilcox, Ernesto R. Drelichman, Meredith L. Kilgore, John D. Christein

M1496

One-Step, EUS-Guided Drainage of Pancreatic Pseudocysts: Experience in 52 Patients Colin McKay*, Simon Denley, Ross Carter

M1497

Effectiveness and Safety of EUS Guided Pancreatic Pseudocyst/Abscess Drainage: A Systematic Review of Prospective Studies Priyanka Tiwari*, Nadim S. Jafri, Praveen K. Roy, Mainor R. Antillon

M1498

Therapeutic Endoscopic Ultrasound (EUS) Access and/ or Stenting of Pancreaticobiliary System After Failed Conventional Endoscopic Retrograde Cholangiopancreatography (ERCP) Thomas Thong H. Nguyen, Christopher E. Lee, Charles S. Whang, Patrick B. Truong, V. Raman Muthusamy, Kenneth J. Chang, John G. Lee*

M1499

No Cytopathologist? No Problem Maintaining Yield While Minimizing EUS Guided FNA Passes in a Community Hospital Setting Mukul Arya*, Siddharth Mathur, Niket Sonpal, Philip Mathew, William L. Thelmo, Yashpal Arya

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION I: CLINICAL / BILIARY M1500

Acute Calculous Cholecystitis: Indications for Early Percutaneous Cholecystostomy Orly Barak, Ram Elazay, Liat Appelbaum, Avraham Rivkind, Gidon Almogy*

M1501

Polypoid Lesions of Gallbladder: Diagnosis and FollowUp Hiromichi Ito*, Lucy E. Hann, Michael D'Angelica, Yuman Fong, Ronald P. DeMatteo, David S. Klimstra, Leslie H. Blumgart, William R. Jarnagin

M1502

Single Incision Laparoscopic Cholecystectomy Using a Flexible Endoscope Glenn Forrester*, Eugenius J. Harvey, Steven Binenbaum, John N. Afthinos, Grace J. Kim, Julio Teixeira

M1503

Laparoscopic Cholecystectomy As a Standardized Teaching Operation: A Comparison of Operative Complications and Short-Term Outcome Between Surgical Residents and Attending Surgeons in 1220 Patients Rene Fahrner*, Matthias Turina, Valentin Neuhaus, Thomas Kostler, Othmar Schöb

M1504

Malignant Melanoma of Lung and Gallbladder, Presenting with Hemoptysis: A Case Report and Review of Literature Ming-Chin Yu*, Miin-Fu Chen, Yi-Yin Jan

M1505

Choledochal Cysts: Risk of Malignancy and Outcome in 68 Patients Undergoing Surgical Management At a Single Institution John P. Bois*, Michael L. Kendrick, Michael B. Farnell, Florencia G. Que, John H. Donohue, Christopher Moir, David Nagorney

M1506

Single Incision Laparoscopic Cholecystectomy Michael Albrink*, Connor Morton, Desiree Villadolid, Sharona B. Ross, Sarah Cowgill, Donovan Tapper, Alexander S. Rosemurgy

Denotes DDW Poster of Distinction

P-209

M O N D A Y MAY 19

POSTER SESSIONS—CLINICAL SSAT Poster Session 8:00 AM - 5:00 PM

M O N D A Y MAY 19

Plugging Away At the Anal Fistula: An Exercise in Futility? Galal S. El-Gazzaz*, Massarat Zutshi, Tracy L. Hull

M1509

Clinical Feature and Management of Postoperative Pouch Bleeding After Ileal Pouch-Anal Anastomosis (IPAA) Lei Lian*, Victor W. Fazio, Feza H. Remzi, Pokala R. Kiran, Christine Hannaway, Bo Shen

M1510

Dosimetric Evaluation of Endoscopic Radiofrequency Ablation in the Human Colonic Epithelium in a Treat and Resect Trial Joseph A. Trunzo*, Michael F. McGee, Benjamin K. Poulose, Joseph Willis, Bridget Ermlich, Michelle Laughinghouse, Bradley J. Champagne, Conor P. Delaney, Jeffrey M. Marks

M1511

A Population-Based Study of Surgical Treatment of Colon Cancer in Ontario, Canada Rahima Nenshi*, Marko Simunovic, Nancy N. Baxter, Nadia Gunraj, Erin Kennedy, Sue Schultz, Drew Wilton, David R. Urbach

M1512

Health Related Quality of Life and Clinical Outcome After Colonic Resection for Diverticular Disease: LongTerm Results Marco Scarpa, Duilio Pagano, Cesare Ruffolo, Anna Pozza, Francesa Erroi, Lino Polese, Davide F. D'Amico, Imerio Angriman*

M1513

Prognostic Factors for Survival in 61 Patients with Carcinoma of the Splenic Flexure Simon S. Ng*, Janet F. Lee, Wing Wa Leung, Raymond Y. Yiu, Jimmy C. Li, Sophie S. Hon, K. L. Leung

M1514

Risk of Infection and Recurrence Over Prolonged Follow Up in Patients Undergoing Ventral Hernia Repair During Colorectal Resection - Can the Use of Mesh Be Justified? Levilester B. Salcedo*, Ravi P. Kiran, Ian Lavery, James M. Church, Victor W. Fazio

M1515

The Prognostic Significance of Circumferential Resection Margin Involvement in Colon Cancer Selman Sokmen*, Mucahit Ozbilgin, Aras Emre Canda, Sulen Sarioglu, Ozgul Sagol, Mehmet Fuzun

M1516

Results of Surgical Treatment of Local Recurrence in Rectal Cancer Patients Jörn Gröne*, Martin Kruschewski, Joerg P. Ritz, Uwe Pohlen, Hubert G. Hotz, Monika Ciurea, Anton J. Kroesen, Heinz J. Buhr

M1517

Preoperative Plasma Levels of Fractalkine (CX3CL1) Are Significantly Lower in Patients with Adenocarcinoma of the Colon When Compared to Benign Disease Patients Aviad Hoffman*, Raymond Baxter, Ik-Yong Kim, Kumara H. Shantha, Abu Nasar, Vesna Cekic, Vincent DiMaggio, Daniel L. Feingold, Richard L. Whelan

M1518



Hemorrhoidectomy in Day Surgery: A Comparison Between Four Techniques Vito Maria Stolfi, Pierpaolo Sileri*, Chiara Micossi, Alessandro Falchetti, Achille Lucio Gaspari

M1519

Comparison of Quality of Life (QOL) Between Ileal J Pouch-Anal Anastomosis and Permanent Ileostomy After Proctocolectomy for Ulcerative Colitis in Elderly Patients Munenori Nagao*, Kouhei Fukushima, Chikashi Shibata, Koh Miura, Hitoshi Ogawa, Yuji Funayama, Michiaki Unno, Iwao Sasaki

P-210

CT Scan in the Diagnosis of Acute Appendicitis: Help or Hindrance? Akpofure Peter Ekeh*, Benjamin Monson, Curtis Wozniak, Jennell Smith, Mary C. McCarthy, Alex Little

M1521

The Likely Cause of Postoperative “Feeding Intolerance” and Its Prevention Gerald Moss

M1522

The Clinical Significance of Adult Intussusception Found By Computed Tomography Parissa Tabrizian*, Scott Q. Nguyen, Alexander Greenstein, Uma Rajhbeharrysingh, Pamela A. Argiriadi, Meade Barlow, Tiffany E. Chao, Celia M. Divino

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION I: CLINICAL / COLON-RECTAL M1508

M1520

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION I: CLINICAL / ESOPHAGEAL M1523

Gastroesophageal Reflux Disease and Connective Tissue Disorders. Pathophysiology and Implications for Treatment Warren J. Gasper*, Piero Fisichella, Francesco Palazzo, Marco G. Patti

M1524

Association of Gastroesophageal Reflux and O2 Desaturation in Patients with GERD; a Novel Study of Simultaneous 24-Hour Impedance-pH and Continuous Pulse-Oximetry Renato Salvador*, Fernando A. Herbella, Attila Dubecz, Marek Polomsky, Thadeus Trus, Carolyn E. Jones, Daniel Raymond, Thomas J. Watson, Jeffrey H. Peters

M1525

Acid Reflux to the Proximal Esophagus Predicts Postoperative Success in Patients with Laryngopharyngeal Reflux Disease Carlos Godinez*, Stephen M. Kavic, George T. Fantry, Paul F. Castellanos, J. Scott Roth, F Jacob Seagull, Adrian E. Park

M1526

Outcomes Following Esophagogastrectomy in Octogenarians Sebastian A. Defranchi*, Francis C. Nichols, Claude Deschamps, Mark S. Allen, Stephen D. Cassivi, Dennis A. Wigle, K.Robert Shen

M1527

Analyzing Treatment Costs for Esophageal Cancer Patients At Different Stages Chih-Cheng Hsieh*, Ching-Wen Chien

M1528

Incorporation of Biologic Mesh Into Crural Closure Decreases Complications and Recurrence of Paraesophageal Hernias Tayyab S. Diwan*, Michael Ujiki, Yashodhan S. Khajanchee, Christy M. Dunst, Lee L. Swanstrom

M1529

New Techniques for Endoscopic (Laparoscopic and Thoracoscopic) Esophagectomy of Esophageal Cancer, Ropeway Technique for Dissection Along with the Nerve and Double-Gloving Method of HALS for Reconstruction Hitoshi Satodate*, Haruhiro Inoue, Shin-ei Kudo

M1530

Accidental Mucosal Perforation During Laparoscopic Heller-Dor Myotomy Does Not Affect the Final Outcome of the Operation Mario Costantini*, Christian Rizzetto, Lisa Zanatta, Elena Finotti, Alessandra Amico, Loredana Nicoletti, Emanuela Guirroli, Giovanni Zaninotto, Ermanno Ancona

M1531

Prevalence of Kyphoscoliosis Among Patients with Giant Paraesophageal Hernia: Proposed Pathophysiology and Clinical Significance Matthew J. Schuchert*, Prasad Adusumilli, Chris C. Cook, Brian L. Pettiford, Joshua P. Landreneau, Ricardo S. Santos, James D. Luketich, Rodney J. Landreneau



Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL M1532

Preoperative Chemoradiation with Intensify-Modulated Radiation Therapy (IMRT) Increases Pathological Complete Response Rate in Locally Advanced Squamous Cell Carcinoma of the Esophagus Chadin Tharavej*, Patpong Navicharern

M1543

Risk Factors for Postoperative Complications After Pancreatic Head Resection: Multivariate Analysis of 608 Consecutive Operations Tobias Keck*, Frank Makowiec, Eva Fischer, Ulrich Adam, Ulrich T. Hopt

M1544

Quality of Life After Total Pancreatectomy: Requiem for a Surgical Dogma? Roberto Salvia*, Silvia Germenia, Stefano Partelli, Stefano Crippa, Claudio Bassi, William Mantovani, Massimo Falconi, Paolo Pederzoli

M1545

The Assessment of the Malignant Potential of IPMN: How Reliable Is the New Score from Fujino? Dominique Suelberg*, Ansgar M. Chromik, Andrea Tannapfel, Matthias H. Seelig, Ulrich Mittelkötter, Waldemar Uhl

M1546

Volume in Pancreatic Surgery - the German Situation Guido Alsfasser*, Julia M. Kittner, Guenther Kundt, Sven Eisold, Ernst Klar

M1547

Second Liver Resection for Recurrent Metastases of Colorectal Cancer: Perioperative Complications and Oncological Results Hannes Neeff*, Frank Makowiec, Eva Fischer, Oliver G. Opitz, Ulrich Adam, Ulrich T. Hopt

The Lymph Node-Ratio Is the Strongest Factor Predicting Survival After Resection of Pancreatic Cancer Frank Makowiec*, Hartwig Riediger, Eva Fischer, Tobias Keck, Oliver G. Opitz, Ulrich Adam, Ulrich T. Hopt

M1548



Dynamic Magnetic Resonance Imaging (DMRI) of the Pancreas As a Predictor of Anastomotic Leakage After Pancreatic Resections Marco Niedergethmann*, Dietmar J. Dinter, Stefan Post

M1536

A Decision Analysis Model of Hepatectomy vs. Radiofrequency Ablation for Hepatocellular Carcinoma Amanda Cooper*, Mary A. Maluccio

M1549

M1537

Image-Guided Laparoscopic Radiofrequency Ablation of Giant Liver Hemangiomas Rocio Anula*, Ernesto Santos Martin, Julio M. Mayol, Iris Sanchez-Egido, Jesus A. Fernandez-Represa

Combination of Bioabsorbable Polyglicolic Acid (PGA) Felt and Fibrin Glue for Prevention of Pancreatic Fistula Following Pancreaticoduodenectomy Kenichiro Uemura*, Yoshiaki Murakami, Yasuo Hayashidani, Takeshi Sudo, Yasushi Hashimoto, Akira Nakashima, Hiroyuki Nakamura, Taijiro Sueda

M1550

M1538

Monopolar Floating Ball Versus Bipolar Forceps for Hepatic Resection: A Prospective Randomized Clinical Trial Guido Torzilli*, Matteo Donadon, Matteo Marconi, Fabio Procopio, Angela Palmisano, Daniele Del Fabbro, Florin Botea, Marco Montorsi

Radiofrequency Ablation of Locally Advanced Pancreatic Cancer Jennifer Logue*, Edward Leen, Susan J. Moug, Ross Carter, Colin McKay

M1551

Antibacterial Prophylaxis Does Not Prevent Infection of Pancreatic Necrosis in Acute Pancreatitis Eduardo A. Villatoro*, Mubashir G. Mulla, Richard I. Hall, Mike Larvin

M1552

Development of a Dedicated Team Decreases ICU Admission After Pancreaticoduodenectomy (PD) Julio Sokolich*, Christos A. Galanopoulos, Allison Vo, Maggie White, Ernest Dunn, D. Rohan Jeyarajah



SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION I: CLINICAL / HEPATIC M1533

Hepatobiliary Resection with Inferior Vena Cava Resection and Reconstruction Using An Autologous Patch Graft for Intrahepatic Cholangiocarcinoma Tsuyoshi Sano*, Kazuaki Shimada, Minoru Esaki, Yoshihiro Sakamoto, Tomoo Kosuge, Yasuhiro Shimizu, Yuji Nimura

M1534

Postoperative Complications After Liver Resections for Colorectal Metastases: Analysis of Risk Factors and Influence of Preoperative Chemotherapy Frank Makowiec*, Ulrich Adam, Hannes Neeff, Ulrich T. Hopt

M1535

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION I: CLINICAL / PANCREAS M1539



Long Term Follow-Up (7 - 34 Years) After Surgical Treatment of Chronic Pancreatitis Sergio Pedrazzoli*, Claudio Pasquali, Stefano Guzzinati, Mattia Berselli, Cosimo Sperti

M1553

M1540

High Complication Rate After Pancreas Preserving Surgical Procedures for Benign or Borderline Pancreatic Lesions. Careful Selection of Patients Is Needed Cosimo Sperti, Claudio Pasquali, Mattia Berselli, Laura Frison, Tania Saibene, Sergio Pedrazzoli*

SSAT Poster Session 8:00 AM - 5:00 PM

M1541

Predictable Factors for Poor Outcome After Severe Acute Pancreatitis Takeo Yasuda*, Yoshifumi Takeyama, Takashi Ueda, Makoto Shinzeki, Hidehiro Sawa, Yonson Ku, Yoshikazu Kuroda, Harumasa Ohyanagi

M1542

Serum Immunosuppressive Acidic Protein Levels in Patients with Severe Acute Pancreatitis Makoto Shinzeki*, Takashi Ueda, Yoshifumi Takeyama, Takeo Yasuda, Kenro Hirata, Hirochika Toyama, Ippei Matsumoto, Toshiaki Tsujimura, Tsunenori Fujita, Tetsuo Ajiki, Yonson Ku

Predictive and Prognostic Value of CA 19-9 in Resected Pancreatic Adenocarcinoma Joshua G. Barton*, John P. Bois, Christina M. Wood, Rui Qin, Michael L. Kendrick, Michael B. Farnell

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION I: CLINICAL / SMALL BOWEL M1554

Long-Term Outcome After Distal Gastric Bypass Combined with Swedish Adjustable Gastric Banding (SAGB) Bruno M. Balsiger*, Folkert Maecker, Andreas Glaettli

M1555

Gastro Intestinal Intramural Hematomas Versus Mesenteric Ischaemia- Clinico-Radiological Profile Sudhindran Surendran*, Unnikrishnan Gopalakrishnan, Dayananda Lingegowda, Sudheer Othiyil Vayoth, Puneet Dhar

Denotes DDW Poster of Distinction

P-211

M O N D A Y MAY 19

POSTER SESSIONS—CLINICAL SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION I: CLINICAL / STOMACH M1556

Laparoscopic Lymphatic-Basin Dissection As An Additional Treatment to Endoscopic Submucosal Dissection in Early Gastric Cancer Toshiyuki Mori*, Nobutsugu Abe, Masanori Sugiyama, Yutaka Atomi

M1557

Long Term Improvement of Co Morbidities in Older and Medicare Patients with Gastric Bypass Peter T. Hallowell*, Thomas A. Stellato, John Jasper, Kristen Graf, Margaret M. Schuster

M1558

Indications and Results of Reversal of Vertical Banded Gastroplasty (VBG) Rebecca Thoreson*, Joseph Cullen

M1559

Gastrectomy and Lymphadenectomy for Gastric Cancer: Is the Pancreas Safe? Fernando A. Herbella*, Ana C. Tineli, Jorge L. Wilson, Jose C. Del Grande

M1560

Long Term Results of Completion Gastrectomies in Patients with Post-Surgical Gastroparesis James E. Speicher*, Richard C. Thirlby, Joseph Burggraaf, Christopher P. Kelly, Sarah M. Levasseur

M1561

Is Neoadjuvant Chemoradiation for Locally Advanced Gastric Cancer Feasible? Brian R. Untch*, Michael E. Barfield, Johanna C. Bendell, Brian G. Czito, Christopher G. Willett, Theodore N. Pappas, Rebekah White, Douglas S. Tyler

M1562

Inpatient Mortality Analysis of Paraesophageal Hernia Repair in Octogenarians Benjamin K. Poulose*, Jeffrey M. Marks, Christine Gosen, Leena Khaitan, Michael J. Rosen, Joseph A. Trunzo, Jeffrey L. Ponsky

M1563

Surgeon Performed Endoscopic Balloon Dilation for Gastrojejunostomy Stenosis Atul K. Madan*, Khurram Khan, David S. Tichansky

M1564

Qualifying the Relationship: Interaction Effects in the Correlation Between BMI and Abdominal Wall Thickness Mark Ranzinger*, F Jacob Seagull, Adrian E. Park

M O N D A Y MAY 19

P-212

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC BASIC AASLD Poster Session 8:00 AM - 5:00 PM

M1565

The Role of Ccr2 in Hepatic Fibrosis and Cancer Ekihiro Seki*, Samuele De Minicis, Robert F. Schwabe, David A. Brenner

M1566

Cellular Senescence and Cell Cycle Markers in An Experimental Model of Liver Cirrhosis Maria del Carmen Garcia de Leon Mendez*, Gabriela Gutierrez-Reyes, Guillermo Robles Diaz, Angelica CuapioGomez, Claudia I. Gonzalez-Rosado, Mario T. Mendoza Carrasco, Yesika Oliva-Fuentes, Gabriela Togno-Latour, Eusebio Tello-Montes, Irmgard Montfort-Happel, Ruy PerezTamayo, David Kershenobich

M1567

CpG Motifs Induce Proinflammatory Events in Hepatic Stellate Cells and Are Involved in Bile Duct LigationInduced Hepatic Fibrosis In Vivo Erwin Gäbele*, Matthias Froh, Reiner Wiest, Florian Obermeier, Jürgen Schölmerich, Claus Hellerbrand

M1568

Anti-Fibrogenic Effects of Lithospermate B in Human Hepatic Stellate Cells and Thioacetamide-Induced Cirrhotic Rats Kwan Sik Lee*, YongHan Paik, YoungJoon Yoon, SoHee Kang, Se-Joon Lee, DongKi Lee, Sang In Lee, Kwang-Hyub Han, ChaeYoon Chon, YoungMyoung Moon

M1569

The Molecular Mechanism of Norepinephrine Induced In Vitro Hepatic Stellate Cell Apoptosis Xiaolan Zhang*, Na Liu, Dongmei Yao, Xiaopeng Tian

M1570

Prospective Comparison of Liver Stiffness Measurement and Lok Index in Chronic Hepatitis C Patients Ryota Masuzaki*, Ryosuke Tateishi, Haruhiko Yoshida, Eriko Goto, Takahisa Sato, Takamasa Ohki, Tadashi Goto, Hideo Yoshida, Yosuke Sugioka, Hitoshi Ikeda, Fumihiko Kanai, Keisuke Hamamura, Shuichiro Shiina, Takao Kawabe, Masao Omata

M1572

M1573

Curcumin Suppresses Insulin-Induced Hepatic Stellate Cell Activation By Interrupting Insulin Signaling and Attenuating Oxidative Stress Jianguo Lin*, Anping Chen

M1577

Culture Activation of Murine Hepatic Stellate Cells Involves Hedgehog Pathway Activation and Epithelial-toMesenchymal Transitions Steve S. Choi*, Alessia Omenetti, Liu Yang, Rafal P. Witek, Kevin D. Brown, Mercedes Vazquez-Chantada, Jiawen Huang, Youngmi Jung, Wing-Kin Syn, Jason K. Sicklick, Anna Mae Diehl

M1578

Adenosine Induces Loss of Actin Stress Fibers and Inhibits Contraction in Hepatic Stellate Cells Via Rho Inhibition Muhammad A. Sohail*, Azuma Watanabe, Shamail Mahmood, Ardeshir Z. Hashmi, Wyel Hakim, Wajahat Z. Mehal

M1579

Insulin-Mediated Signaling Events in the Activation of Hepatic Stellate Cells Cindy X. Cai*, Rosemary O'Neill, Robert Britton, Bruce R. Bacon

M1580

Loss of Hepatic Stellate Cell Lipid Droplets Does Not Contribute to Stellate Cell Activation and Liver Fibrosis Johannes Kluwe*, Nuttaporn Wongsiriroj, Roseann Zott, William S. Blaner, Robert F. Schwabe

M1581

Anti-Copper Therapy Protects Against Hepatic Fibrosis By Down-Regulating Collagen Iα1 mRNA Expression in Hepatic Stellate Cells Ming Song*, Zhenyuan Song, George Brewer, Craig J. McClain

M1582

Hedgehog Signaling Pathway in Primary Human Hepatic Stellate Cells Kevin D. Brown*, Jude A Oben, Barbara Sigala, Liu Yang, Alessia Omenetti, Jason K. Sicklick, Hendrika Vandongen, Anna Mae Diehl

M1583

Inhibition of NADPH Oxidase Suppresses Fibrogenesis Ghazaleh Aram*, James J. Potter, Xiaopu Liu, Esteban Mezey

M1584

The Autonomic Neurotransmitter Acetylcholine Induces Fibrogenic Responses in Human Primary Hepatic Stellate Cells Morgan Maelle, Barbara Sigala, Clare Selden, Anna Mae Diehl, Jude A. Oben*

M1585

Effects of FAK-Related Non-Kinase Plasmid Transfection On Fibronectin-Stimulated Hepatic Stellate Cell Behavior Xiaolan Zhang*, Junyan An, Jiangang Shen, Xiaoxia Huo, Juan Wei

Sails Pavilion San Diego Convention Center

STELLATE CELL BIOLOGY AND HEPATIC FIBROGENESIS

M1571

M1576

Relaxin: An Antifibrotic Hormone in Patients with Liver Disease Nandini Channabasappa*, Marlyn J. Mayo AST/ALT, APRI, and Magnetic Resonance Elastography for Detection of Advanced Fibrosis in Clinical Practice Jayant A. Talwalkar*, John B. Gross, Sudhakar Venkatesh, Meng Yin, James Glockner, Naoki Takahashi, Patrick S. Kamath, Richard L. Ehman Comparison of TRANSIENT ELASTOGRAPHY, APRI Score, ALT/AST Ratio to Laparoscopic Liver Biopsy in Patients with Liver Disease Chakradhar M. Reddy*, Srinivas Gaddam, Carmine G. Nudo, Zvi Leibovici, Luis A. Servin-Abad, Maria D. De Medina, Lennox J. Jeffers, Eugene Schiff

M1574

Understanding Pathophysiology of Hyperventilation in Cirrhosis Joye Varghese, Arun Kumar Muthusamy*, Sowmya Sowmya S, Jayanthi Venkatraman

M1575

Are Non-Invasive Biochemical Markers Useful in the Assessment Liver Fibrosis in Patients with Chronic Hepatitis C? José Luis Castro Urda*, Cristina Vicente, Elvira Quintanilla, Marta Morán, David Collado, Ivan Guerra, Luis R. Rabago, Francisco Gea

M1586

Development of Cirrhosis Is Associated with Increased Levels of Placental Growth Factor: A Descriptive Study Christophe Van Steenkiste*, Ben Schroyen, Anja M. Geerts, Eline Vanheule, Hans Van Vlierberghe, Debby Laukens, Kim Olievier, Hendrik Reynaert, Albert Geerts, Martine De Vos, Isabelle Colle

Denotes DDW Poster of Distinction

P-213

M O N D A Y MAY 19

POSTER SESSIONS—BASIC AGA Institute Poster Session 8:00 AM - 5:00 PM

M1596

Evaluation of p53, Ki67 and Flow Cytometry for Prediction of Neoplastic Progression in Barrett Esophagus Marjolein Sikkema*, Marjon Kerkhof, Herman van Dekken, Johannes G. Kusters, Paulina M. van Strien, E. W. Steyerberg, Caspar W. Looman, Peter D. Siersema, E. J. Kuipers

M1597

Expression and Localization of MnSOD in Response to Bile Acid Salts in Esophageal Epithelial Cell Yan Li*, Qiaohong Liu, Nathaniel P. Reuter, John M. Wo, Jingwen Zhang, Robert C. Martin

M1598

Low Rate of Invasive Adenocarcinoma At Esophagectomy for High-Grade Dysplasia or Intramucosal Adenocarcinoma in Patients with Barrett's Esophagus Victor S. Wang*, Jason L. Hornick, Joe A. Sepulveda, John M. Poneros

M1599

The Transforming Properties of the Barrett's Associated Protein, AGR2, Are Enhanced By AGR3 in NIH3T3 Cells Anson W. Lowe*, Ying Hao

M1600

Upregulation of the Mir-25-93-106b Cluster in Barrett'sAssociated Neoplastic Progression Kwisa Kang*, Fumiaki Sato, Tetsuo Ito, Stefan David, Yulan Cheng, Yuriko Mori, Rachana Agarwal, Bogdan C. Paun, Zhe Jin, Alexandru Olaru, Florin Selaru, James P. Hamilton, Jian Yang, John M. Abraham, Stephen J. Meltzer

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

BARRETT'S-RELATED ESOPHAGEAL ADENOCARCINOMA Participants will be able to: • Learn about molecular biology of Barrett's-related adenocarcinoma. M1587



The Mucin Phenotypes and Claudin Expressions in Esophageal Adenocarcinoma and the Surrounding Mucosa Takayo Sakano*, Ryoji Kushima, Shizuki Takemura, Kenichi Mukaisho, Michael Vieth, Manfred Stolte, Kaiyo Takubo, Takanori Hattori

M1588



Impact of Previous Diagnoses of Barrett's Esophagus and GERD and Prior Endoscopy On Outcome from Esophageal Adenocarcinoma: A Population-Based Analysis Gregory S. Cooper*, Tzuyung D. Kou, Amitabh Chak

M1589

Lack of Temporal Changes in Diagnosis of Barrett's Esophagus and Prior Endoscopy in Patients with Esophageal Adenocarcinoma Gregory S. Cooper*, Tzuyung D. Kou, Amitabh Chak

M1590



Rabeprazole Impedes the Development of Reflux Induced Esophageal Cancer in a Surgical Rat Model Tomoharu Miyashita*, Furhawn A. Shah, Jiaai Wang, Guy Marti, Mark D. Duncan, Elizabeth A. Montgomery, Manabu Murakami, John W. Harmon

M1601

M1591

Activation of HGF/c-MET Is the Key Mechanism for Acid-Induced Proliferation of Barrett's-Derived Esophageal Cancer Cells. Critical Roles of Functional EGFR and COX-2 in C-MET Activation and Therapeutic Implications Thomas Thong H. Nguyen*, Amrita Ahluwalia, Andrzej Tarnawski

Does Superficial Submucosal Tumor Invasion in Esophageal Adenocarcinoma Limit Survival? Rami J. Badreddine*, Kenneth K. Wang, Ganapathy A. Prasad, Navtej Buttar, Louis-Michel Wong Kee Song, Kelly T. Dunagan, Lori S. Lutzke, Lynn S. Borkenhagen, Jason T. Lewis

M1602

Analysis of p53 Protein and Ki67 Mib—1 Antigen Expression in the Esophageal Mucosa of Patients in the Gastroesophageal Reflux Disease — Barrett's Esophagus — Adenocarcinoma Sequence Marcelo Binato, Renato B. Fagundes, Luise Meurer, Maria Isabel A. Edelweiss, Richard R. Gurski*

M1603

Should Endoscopic Ultrasonography (EUS) Be Performed in Barrett's Esophagus (Be) Patients with Flat High Grade Dysplasia and/or Mucosal Adenocarcinoma? Amit Rastogi*, Ajay Bansal, Mojtaba S. Olyaee, Sachin B. Wani, Krishna Pondugula, April D. Higbee, Sharad C. Mathur, Prateek Sharma

M1604

Relation of Goblet Cell Density and Early Esophageal Adenocarcinoma Within Long Segment's Barrett's Esophagus Jessica M. Leers*, Steven R. DeMeester, Ann Z. Tan, Arzu Oezcelik, Shahin Ayazi, Emmanuele Abate, Farzaneh Banki, John C. Lipham, Jeffrey A. Hagen, Tom R. DeMeester

M1592

M O N D A Y MAY 19

M1593

Long-Term Survival Following Endoscopic and Surgical Treatment of Mucosal (T1a) Esophageal Adenocarcinoma in Barrett's Esophagus Ganapathy A. Prasad*, Rami J. Badreddine, Navtej Buttar, Louis-Michel Wong Kee Song, Dennis A. Wigle, Lori S. Lutzke, Kelly T. Dunagan, Lynn S. Borkenhagen, Kenneth K. Wang Setting the Stage for Inflammatory Actors: Acid-Induced NF-kB Signaling Decreases the Apoptotic Effects of TNFα in Esophageal Adenocarcinoma Cells Stefan David*, Tetsuo Ito, Yuriko Mori, Alexandru Olaru, Bogdan C. Paun, Florin M. Selaru, Kwisa Kang, Yulan Cheng, James P. Hamilton, Jian Yang, Rachana Agarwal, Fumiaki Sato, John M. Abraham, Stephen J. Meltzer

M1594

Five Year Survival of Patients with Esophageal Adenocarcinoma Identified During An Annual Surveillance Programme Keith Roberts*, Edward Harper, Mike Hallissey

M1605

The Incidence and Classification of Esophagogastric Junction Adenocarcinoma in Korea Jun-Won Chung*, Hwoon-Yong Jung, Kee Wook Jung, JinHo Kim, Kee Don Choi, Kwi-Sook Choi, Ho June Song

M1595

Topo IIα and HER-2/neu Overexpression/Amplification in Barrett's Esophagus, Dysplasia and Adenocarcinoma Elisa Rossi*, Vincenzo Villanacci, Salvatore Grisanti, Domenico Della Casa, Guido Missale, Luigi Minelli, Gianpaolo Cengia, Piergiovanni Grigolato, Gabrio Bassotti, Renzo Cestari

M1606

Type I (Barrett's) Adenocarcinoma As a Distinct Paradigm in Junctional Tumours: Rationale for Simplifying the AEG Classification System Narayanasamy Ravi*, Bussa Gopinath, Patrick J. Byrne, John V. Reynolds

M1607

GERD, Barrett's Esophagus (BE), and Esophageal Adenocarcinoma (EA) in South Carolina in 2006: Geographic Analysis of Prevalence and Effect of Availability of Endoscopy Centers Lubin F. Arevalo*, Marcelo F. Vela

P-214

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC M1608

The Esophageal Adenocarcinoma and Barrett's Esophagus Registry Consortium: A Large Prospective Resource for Collaborative Multidisciplinary Studies Virender K. Sharma, Michael B. Wallace, Yvonne Romero*

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

M1619

Methylated Protocadherin 10 Is Identified As a Target of Epigenetic Silencing and a Prognostic Predictor in Gastric Cancer Jun Yu*, Yuen Yee Cheng, Qian Tao, Yim Ping Wong, Linwei Tian, Hongchuan Jin, Wai K. Leung, Francis K. L. Chan, Joseph JY Sung

M1620

Caldesmon Suppresses Cancer Cell Invasion By Regulating Podosome/Invadopodium Formation Toshiyuki Yoshio*, Tsuyoshi Morita, Masahiko Tsujii, Jumpei Kondo, Sachiko Nakajima, Shuji Ishii, Shinichiro Shinzaki, Satoshi Egawa, Tsutomu Nishida, Yoshimi Kakiuchi, Hideki Iijima, Shingo Tsuji, Kenji Sobue, Norio Hayashi

M1621

Gene Expression Profile in Colon Cancer Cells in Response to Troglitazone: Impact of XIAP Expression Liang Qiao*, Gloria HY Li, Yun Dai, Zesong Li, Bing Zou, Juan Ma, Marie CM Lin, Benjamin C.Y. Wong

M1622

Loss of Heterozygosity of PTEN Tumor Supressor Gene and Expression Pattern of E-Cadherin in Sporadic Gastric Carcinoma Suck Chei Choi, Hun Soo Kim, Kyu Sang Song, Soo Cheon Chae, Young-Mi Lee, Tae Hyeon Kim, Yong Sung Kim, Chang Soo Choi, Ki Hoon Kim, Ki Jung Yun*

M1623

Differential Expression of iL0r2, Stat1 and STAT3 in Colorectal Cancer Oliver Movadat*, Sabine G. Gruber, Chukwuma A. Agu, Brigitte Marian, Friedrich Wrba, Christoph Gasche

M1624

Identification of Oncogene By Retroviral Expression Screening in Gallbladder Cancer Hisashi Hatanaka*, Kiichi Tamada, Kentaro Sugano, Hiroyuki Mano

M1625

P16 and APC Mutations in Reflux- Barrett's MetaplasiaDysplasia- Adenocarcinoma Sequence Anna Mokrowiecka, Agnieszka Wierzchniewska-Lawska, Beata Smolarz, Hanna Romanowicz-Makowska, Ewa Malecka-Panas*

M1626

Gastric Mucosal Cytokines, Helicobacter pylori Infection and Interleukin-1 Polymorphisms in Gastric Cancer in Thailand Ratha-korn Vilaichone*, Somying Tumwasorn, Varocha Mahachai

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: MOLECULAR GENETICS: ONCOGENES AND TUMOR SUPPRESSORS Participants will be able to: • Evaluate molecular genetics: Oncogenes and tumor suppressors. M1609

M1610

Decreased Expression of the RAS-GTPase Activating Protein RASAL1 Is Involved in Progression of Colorectal Neoplasms Miki Ohta*, Motoko Seto, Dai Mohri, Yoshinari Asaoka, Motohisa Tada, Yasuo Tanaka, Hideaki Ijichi, Fumihiko Kanai, Takao Kawabe, Masao Omata Aurora Kinase a Abrogates Drug-Induced Apoptosis Through Regulating p53 in AKT-Dependent Mechanism Altaf Dar*, Abbes Belkhiri, M. Blanca Piazuelo, Pelayo Correa, Alexander I. Zaika, Antoni Castells, Wael M. ElRifai

M1611



Epigenetic Characterization of a Novel Tumor Suppressor Gene, RNF180, in Gastric Cancer and Its Application in Noninvasive Cancer Detection Kin-Fai Cheung*, Cleo NY Lam, Wai K. Leung, Alfred SL Cheng, Enders K. Ng, Wai-Sing Chong, Hongchuan Jin, Joseph JY Sung, Jun Yu

M1612

RNA Translation Enhancing Protein RBM3 Is a Novel Protooncogene That Induces Anchorage Independent Growth Satish Ramalingam*, Gopalan Natarajan, Randal May, Courtney W. Houchen, Shrikant Anant

M1613

Role of a Chemical Carcinogen and H. pylori in Gastric Oncogenesis: A 5-Year Experimental Study in Rhesus Monkeys Hui Liu, D. Scott Merrell*, Cristina Semino-Mora, Matthew Goldman, Arifur Rahman, Steven Mog, Andre Dubois

M1614

Pancreatic-Duodenal Homeobox 1 (PDX1) Functions As a Tumor Suppressor in Gastric Cancer Juan Ma, Min Hu Chen, Yingjie Liang, Qing Gu*, Jide Wang, Liang Qiao, Yun Dai, Bing Zou, HuiYao Lan, Benjamin C.Y. Wong

M1615

M1616

Aberrant Methylation of Dkk-3 in Gastric Cancer Associated with Poor Outcome Jun Yu*, Qian Tao, Yuen Yee Cheng, Linwei Tian, Kin Fai Cheung, Joseph JY Sung



Functional Significance of a Putative Tumor Suppressor, the Ubiquitin Carboxyl-Terminal Hydrolase L1 Gene, in Multiple Digestive Tumors Jun Yu*, Qian Tao, Hongchuan Jin, Fan Fong Poon, Xian Wang, Hongyu Li, Yuen Yee Cheng, Matthias PA Ebert, Christoph Röcken, Anthony W. Chan, Joseph JY Sung

M1617

PKCδ Is a Negative Regulator of the Hedgehog Pathway By Inhibition of GLI Protein Transcriptional Activity Qingsong Cai*, Jing Li, Tianyan Gao, Jingwu Xie, B. M. Evers

M1618

Regulation of Wnt Signaling By Protein Kinase and Phosphatase Jun Yang*, Chunming Liu

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: PROLIFERATION, SENESCENCE AND APOPTOSIS

MAY 19

Participants will be able to: • Learn about the mechanisms that get activated in response to damage and the mechanisms that promote repair. M1627



SPARC-Induced Apoptosis Is Mediated By a Specific Domain of SPARC That Interacts with Pro-Caspase 8 Michelle J. Tang*, Sonia M. Cheetham, Isabella T. Tai

M1628

Deoxycholyltaurine Rescues Human Colon Cancer Cells from TNF-α-Induced Apoptosis By Activating Nf-κB Signaling Jasleen Shant*, Jian-Ying Wang, Kunrong Cheng, JeanPierre Raufman

M1629

The Role of the Intracellular Tyrosine Kinase PTK6 in Azoxymethane-Induced Colorectal Carcinogenesis Jessica Gierut*, Wenjun Bie, Andrea Haegebarth, Robert E. Carroll, Angela L. Tyner

Denotes DDW Poster of Distinction

M O N D A Y

P-215

POSTER SESSIONS—BASIC M1630

Novel Intestinal Splice Variants of RNA Binding Protein CUGBP2: Isoform Specific Effects On Mitotic Catastrophe Satish Ramalingam*, Gopalan Natarajan, Chris Schafer, Randal May, Ilangovan Ramachandran, Lurdes Queimado, Courtney W. Houchen, Shrikant Anant

M1631

Perturbations in Gp130 Mediated STAT3 Signaling in the Fundic Stomach Mucosa Mimic Pro-Carcinogenic Changes Induced By Helicobacter pylori Infection Meegan Howlett*, Louise M. Judd, Cameron Jackson, Andrew S. Giraud

M1632

M1633

M1634

M1635

M1636

M1637

M O N D A Y

Increased Cellular Senescence Is Induced By CPT-11 in Colorectal Cancer Cells in the Presence of Secreted Protein Acidic and Rich in Cysteine (SPARC) Justin M. Chan*, Michelle J. Tang, Isabella T. Tai XIAP-Associated Factor 1 (XAF1) Regulates p53Mediated Apoptosis By a Negative Feedback Loop Bing Zou*, Roberta Pang, Liang Qiao, Likwai Wong, Juan Ma, Yan Wang, Hui Zeng, HuiYao Lan, Benjamin C.Y. Wong Overexpression of Retinoic Acid-Regulated Nuclear Matrix-Associated Protein (RAMP) Induces Cell Proliferation in Gastric Cancer: Potential Oncogenic Role of Ramp in Gastric Carcinogenesis Julia J. Li, Enders K. Ng*, Yu P. Ng, Jun Yu, Joseph J. Sung, Nancy Y. Ip, Wai K. Leung Helicobacter pylori cagA Cytotoxin Stimulates Inappropriate STAT3 Activation in Gastric Epithelial Cells By a Phosphorylation Dependent Mechanism Trevelyan Menheniott*, Cameron Jackson, Naoko MurataKamiya, Masanori Hatakeyama, Andrew S. Giraud Gene-Expression Signature-Based Approach Identifies Pro-Apoptotic Compounds in CACO-2 Cell Line Trinidad Montero, Xavier Llor, Antonio Suarez*

M1644

Characterisation of Progenitor Cells in Colorectal Cancer and the Adult Human Colon Jamie Murphy*, Sahira Khalaf, Rebecca Hands, Jun Tian, Norman S. Williams, Stephen A. Bustin

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Growth, Development & Aging

MOLECULAR MECHANISMS OF DEVELOPMENT AND DIFFERENTIATION Participants will be able to: • Learn more about the molecular mechanisms of development and differentiation. M1645



Role of PTEN Phosphatase in Intestinal Homeostasis and Tumor Initiation Marie-Josée Langlois*, Sébastien B. Roy, Benoit A. Auclair, Christine Jones, Francois Boudreau, Julie Carrier, Nathalie Rivard, Nathalie Perreault

M1646

The Intracellular Tyrosine Kinase PTK6 Phosphorylates Beta-Catenin and Negatively Regulates Beta-Catenin/Tcf Transcription Helena L. Palka-Hamblin, Jessica Gierut*, Patrick M. Brauer, Yu Zheng, Angela L. Tyner

M1647

Extracellular Calcium-Sensing Receptor (CaSR) Stimulates Secretion of the Wnt Antagonist, DKK-1, from Colonic Myofibroblasts to Increase Transepithelial Resistance of T84 Monolayers Ivan I. Pacheco*, R. John MacLeod

M1648

Etiology of Barrett's Esophagus: Expression of Hox Genes in the Human Esophagus Anouk Van de Winkel*, Karin Ackema, Paulina M. van Strien, Peter D. Siersema, Johannes G. Kusters, E. J. Kuipers, Jeroen Charité

M1649

Transcriptional Control of Epithelial Cell Identity: Dynamic Expression of Cell-Intrinsic Factors During Formation of the Pyloric Border Aaron M. Udager*, Xing Li, Xiaotan Qiao, Deborah L. Gumucio



Role of RelA/P65 in Proliferation, Apoptosis and Trandifferentiation in the Mouse Model of Pancreatic Tumor Marina Lesina*, Hana Algül, Matthias Treiber, Karen Dlubatz, Stephan Paxian, Roland M. Schmid

M1638

Aspirin Synergistically Enhances Apoptosis and Reverses Chemotherapy Resistance in TherapyRefractory Colorectal Cancer Cells Michelle J. Tang*, Isabella T. Tai

M1650

M1639

Guggulsterone Induces Apoptosis in Colon Cancer Cells and Inhibits Tumor Growth in a Murine Xenograft Model: Therapeutic Potential in the Treatment of Colorectal Cancer Min Ji An*, Jae Hee Cheon, TAE IL KIM, Won Ho Kim

Role for iLK in the Control of Fibronectin Expression and Deposition in Human Intestinal Epithelial Cells David Gagne*, Pierre H. Vachon, Jean-Francois Beaulieu

M1651

CK2 Inhibition Sensitizes Chemopreventive-Induced Apoptosis of Colon Carcinoma Cells Serge Dionne*, Denise Levesque, Ernest G. Seidman

Micrornas in Villus and Crypt Epithelial Cells of the Small Intestine Anne M. Hutson*, Chad A. Shaw, Preethi H. Gunaratne, Susan J. Henning

M1652

Interelukin-18 Regulates MUC2 Gene Expression Through Transcription Factors of Goblet Cells Kensei Nishida*, Mai Kamizato, Yuta Yamamoto, Kiyoshi Masuda, Tomoko Kawai, Shigetada Teshima-kondo, Kazuhito Rokutan

M1640

MAY 19 M1641

Anti-Gastric Cancer Effect of Celecoxib, a Selective COX-2 Inhibitor, Through Inhibition of AKT Signaling Nayoung Kim*, Chung Hyun Kim, Ji Hyun Park, Mi Kyung Lee, Soo-Jeong Cho, Joo Sung Kim, Hyun Chae Jung, In Sung Song

M1642

Simvastatin Potentiates Sensitivity to Apoptosis in Microsatellite-Unstable Colon Cancer Cells Yeon Sil Jang*, Eun Suk Choi, Dong Kyung Chang, YoungHo Kim, Poong-lyul Rhee, Jae J. Kim, Jong Chul Rhee

M1643

GSK3 Activity Regulates Proliferation and Survival of Human Pancreatic Cancer Cells Benoit Marchand, Marie-Josee Boucher*

P-216

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC AGA Institute Poster Session 8:00 AM - 5:00 PM

M1662

Involvement of STAT3 in IL-6 and IFN-γ Induced Enteric Apelin Expression Song Han*, Guiyun Wang, Xiang Qi, George H. Greeley

M1663

A Role for the Apelin-APJ System in Enteric Cell Proliferation During Hypoxia Song Han*, Guiyun Wang, Xiang Qi, Ella W. Englander, George H. Greeley

M1664

Loss of Purinergic Modulation of Gastrointestinal Blood Flow During Colitis Is Associated with Increased Expression and Activity of CD39 Shadi Neshat, Maaike deVries, Alma Barajas-Espinosa, Susan Chisholm, Alan Lomax*

M1665



Role of Muscarinic 3 Receptors in the Immune, Epithelial, and Smooth Muscle Responses to Enteric Nematode Infection Leon P. McLean*, Aiping Zhao, Rex Sun, Jennifer A. Stiltz, Diana C. Riera, Joseph F. Urban, Jean-Pierre Raufman, Terez Shea-Donohue

M1666

Trinitrobenzene Sulfonic Acid (TNBS) Colitis Elicits Differential Changes in Receptor Tyrosine Kinase TrkA and TrkB in Colonic Afferent Neurons in DRG Li-Ya Qiao*, John R. Grider

Sails Pavilion San Diego Convention Center

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

HORMONES & RECEPTORS IN FOOD INTAKE AND METABOLIC DISORDERS Participants will be able to: • Learn about the role of hormones and receptors in metabolic disorders and food intake. M1653



Cellular and Functional Mechanisms Underlying the Gastroinhibitory Effects of Glucagon-Like Peptide-1 (GLP-1) in Rat Gregory M. Holmes, Zhongling Zheng, Melissa Tong, R. Alberto Travagli*

M1654

Children with a Metabolic Disorder and Persistent Anorexia Have Low Plasma Ghrelin Marjan Mulleman, Francois Eyskens, Inge Depoortere, Sofie Staelens, Sigrid Beernaert, Theo L. Peeters, Gigi Veereman*

M1655

GI Hormonal Changes After Roux-en-Y Gastric Bypass (RYGBP): A Meta-Analysis Xinqing Fan*, Joseph H. Sellin

M1667

M1656

Influence of a Chronic High Fat Diet On Orexigenic Effects of Growth Hormone-Releasing Peptide (GHRP-6) and Ghrelin George H. Greeley*, Jason T. Reed, Ella W. Englander

Glucagon-Like Peptide-2 Receptor Agonist Ameliorates Murine Inflammatory Ileus Beverley A. Moore, Jeffrey M. Palmer, Sarah L. Sague, Thomas Nesspor, Allison Pirone, Pamela J. Hornby*

M1668

Gastric and Circulating Leptin Levels Are Related to Degree of Helicobacter pylori-Associated Gastritis Jatin Roper*, Fritz Francois, Zhiheng Pei, Guillermo I. Perez-Perez, Asalia Z. Olivares, Peter L. Shue, Michelle Mourad, Martin J. Blaser

M1657

M1658

M1659

M1660



CRF Over-Expressing Mice Display An Altered Food Intake Pattern Under Different Feeding Conditions Compared to Their Wild Type Littermates Miriam Goebel*, Andreas Stengel, Lixin Wang, Mulugeta Million, Peter Kobelt, Hubert Monnikes, Yvette Tache Melanocortinergic Modulation of Food Intake in the Medulla: Evidence for Presynaptic MC4-Receptors On Vagal Afferents ShuXia Wan, Kirsteen N. Browning*, Gregory M. Sutton, Hans-Rudolf Berthoud, R. Alberto Travagli Agonists of Bitter Taste Receptors Activate the GutBrain Axis and Influence Food Intake and Gastrointestinal Function in Mice Shuzhen Hao*, Elvis G. Espero, Michelle Dulake, Catia Sternini, Linda Rinaman, Helen E. Raybould The Endogenous Murine GLP-2 Receptor Is Essential for Nutrient Absorption and the Adaptive Mucosal Response to Disorders of Energy Homeostasis Jasmine Bahrami*, Seung-Jun Lee, Christine Longuet, Bernardo Yusta, Daniel J. Drucker

AGA Institute Poster Session 8:00 AM - 5:00 PM

HORMONES & RECEPTORS IN INFECTION AND INFLAMMATION Participants will be able to: • Understand the role and regulation of hormones and receptors in infection and inflammation.



Sails Pavilion San Diego Convention Center

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

HORMONES AND RECEPTORS IN THE ENTERIC NERVOUS SYSTEM AND BRAIN-GUT AXIS Participants will be able to: • Learn about hormones and receptors function in the enteric nervous system and brain-gut axis. M1669

Active and Inactive Pools of nNOS in the Nerve Terminals in Mice Gut: Implications for Nitrergic Neurotransmission Y. M. Rao, Arun Chaudhury*, Raj K. Goyal

M1670

Choline Transporter: A New Label for Cholinergic Nerves in the Human Enteric Nervous System That Reveals Cholinergic Nerves in Colonic Mucosa Andrea M. Harrington, Margaret Lee, Sim-Yee Ong, Pam Farmer, John M. Hutson, Bridget R. Southwell*

M1671

Modulation of Brainstem Vagal Inhibitory Circuits in Response to Application of CRF and Oxytocin. In Vitro Studies Kirsteen N. Browning*, R. Alberto Travagli

M1672

Differential Effect of CB1 Receptors On the Discharge of Afferent and Efferent Fibres Supplying the Rat Jejunum Jemma Shaw*, Wen Jiang, David C. Bulmer, David Grundy

Sails Pavilion San Diego Convention Center

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

M1661

AGA Institute Poster Session 8:00 AM - 5:00 PM

Regulation of Colonic Trefoil Factor 3 By Apelin Guiyun Wang*, Ramendra K. Kundu, Song Han, Xiang Qi, Ella W. Englander, Thomas Quertermous, George H. Greeley

Denotes DDW Poster of Distinction

P-217

M O N D A Y MAY 19

POSTER SESSIONS—BASIC M1673

Peripheral Injection of Ghrelin Induces FOS Expression in the Dorsomedial Hypothalamic Nucleus in Rats Miriam Goebel*, Anna-Sophia Wisser, Peter Kobelt, Andreas Stengel, Ivo R. van der Voort, Rüdiger W. Veh, Bertram Wiedenmann, Burghard F. Klapp, Yvette Tache, Hubert Monnikes

M1683

Increased Macromolecular Permeability in Non-Inflamed Colon of Ulcerative Colitis Involves Muscarinic Receptor Signalling Via Subepithelial Eosinophils Conny Wallon, Ann-Charlott Ericson, Ping-Chang Yang, Derek M. McKay, Philip M. Sherman, Mary H. Perdue, Johan D. Soderholm*

M1674

Time Course of Gastric Emptying, Plasma Ghrelin Levels and Autonomic Nerves Function in the Chronic Stage of Diabetes in Rats Hajime Ariga*, Kenji Imai, Kirk A. Ludwig, Christopher R. Mantyh, Theodore N. Pappas, Toku Takahashi

M1684

M1675



Intestinal Glucose-Induced Phosphorylation of CalciumCalmodulin Kinase II (CaMkII) in 5-HT-Secreting Enterochromaffin Cells, Myenteric Neurons and Vagal Afferents in the Rat James W. Sharp, Michelle Dulake, Kimberly M. Vincent, Helen E. Raybould*

The Roles of p53 and Death Receptor-5 in Augmenting Activated T-Cell Induced Apoptosis Edwin K. McDonald*, Ramanarao Dirisina, Niklas Finnberg, Meghan Barrett, Tatiana Goretsky, Jennet Manjali, Mutazz Darweesh, Jeffrey Brown, Wafik S. El-Deiry, Terrence A. Barrett

M1685

Curcumin Inhibits IFN-γ Signaling in Colonic Epithelial Cells Monica T. Midura-Kiela, Claire B. Larmonier, Daniel Laubitz, Fayez K. Ghishan, Pawel R. Kiela*

M1686

M1676

Attenuated Ghrelin and PYY3-36 Sensitivity and Responses to Feeding in a Rat Model of Diet-Induced Obesity Zuming Liu*, Terry A. McNearney, Jiande Chen

CXCR6 Is Upregulated in Effector Memory CD4+ T Cells Infiltrating Into Chronically Inflamed Colonic Tissue Yasushi Mandai*, Koji Hase, Toru Sato, Daisuke Takahashi, Masashi Ebisawa, Tatsuro Katsuno, Yasushi Saito, Hiroshi Ohno

M1687

Ecto-Phosphorylation of CD98 Regulates LymphocytesEpithelia Interactions Hang Thi Thu Nguyen*, Yutao Yan, Guillaume Dalmasso, Laetitia Charrier-Hisammudin, Shanthi V. Sitaraman, Didier Merlin

M1688

Dysregulation of the Polymeric Immunoglobulin Receptor in Crohn's Disease Razvan I. Arsenescu*, Maria Bruno, Willem J. de Villiers, Charlotte Kaetzel

M1689

Transferred Naive and Regulatory T Cells Are Mandatory for Normal IEC Differentiation in the Colon of RAG1-/- Deficient Mice Stephanie Dahan*, Masayuki Fukata, Andrea P. Martin, Paul M. Arnaboldi, Lloyd Mayer

M1690

Intestinal Inflammation Up-Regulates the Expression of the G Protein-Coupled Receptor P2Y2 At the Transcriptional Level Émilie Degagné*, Djordje Grbic, Andrée-Anne Dupuis, Fernand-Pierre Gendron

M1691

IFN-γ and Lamina Propria Lymphocytes (LPLS) Regulate Sox9 and Gp180 Expression in Fresh Intestinal Epithelial Cells (IECs) Giulia Roda*, Alessandra Caponi, Andrea Belluzzi, Laura Mezzanotte, Sara Cameli, Michele Grazia, Giampaolo Ugolini, Giancarlo Rosati, Isacco Montroni, Lloyd Mayer, Aldo Roda, Enrico Roda

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

EPITHELIAL CELL IMMUNE FUNCTION AND INTERACTION WITH IMMUNE CELLS Participants will be able to: • Understand the epithelial responses in immune function and interaction with immune cells. M1677

M O N D A Y MAY 19



Galectin-2 and Galectin-4 Modulate Intestinal Epithelial Cell Function and Intestinal Wound Healing Daniela Paclik*, Bertram Wiedenmann, Axel U. Dignass, Andreas Sturm

M1678



Chylomicron Formation Enhances Absorption of Intestinal Luminal Antigens Into Mesenteric Lymph Nodes and Blood Sarbani Ghoshal, Jerold G. Woodward, Jassir Witta, Willem J. de Villiers, Erik Eckhardt*

M1679

Negative Regulation of Chitinase 3-Like-1 By TLR2/4Dependent MyD88 Signaling in Colonic Epithelial Cells Chun Chuan Chen, Shu-Chen Wei, Yuriko Hachiya, Mayumi Kawada, Atsuko Arihiro, Katsuya Nagatani, Elke Cario, Daniel K. Podolsky, Emiko Mizoguchi*

M1680

Intestinal Epithelial Cells Present Food Antigens to Induce FOXP3+ Regulatory T Cells Sonal Gupta*, Seiji Arihiro, Bayasi Guleng, Carmen Alonso, Marianne Boes, Hans-Christian Reinecker

M1692

A New Role of Co-Inhibitory Molecule B7-H1 for Induction of Oral Tolerance Sung Yeun Yang*, Jae Hwan Kim, Su Kyoung Kwon, Sang Hoon Seol, Tae Hee Kim, In Hak Choi

M1681

Intestinal Epithelial Cells Modulate Dendritic Cell Activation Through a Bacterial-Strain Specific TLR9Mediated Mechanism Jody l. Backer*, Naomi Hotte, Karen Madsen

M1693

Expression of the Tight Junction Molecule Claudin-18 Is Increased in Patients with Ulcerative Colitis Gerd Bouma*, Antoon Zwiers, Chris J. Mulder, Georg Kraal

M1682

Compound a (CpdA), a Selective Glucocorticoid Receptor Agonist (SEGRA), Positively Affects Wound Healing While Reducing NF-KappaB Activity in Intestinal Epithelial Cells Kerstin C. Reuter*, Stefan Loitsch, Wolfgang Eberhardt, Jürgen Stein, Carolin Daniel

P-218

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC AGA Institute Poster Session 8:00 AM - 5:00 PM

M1705

Assessment of Small Bowel Safety of Lumiracoxib 100 Mg OD Compared with Naproxen 500 Mg Bid Plus Omeprazole or Placebo Chris J. Hawkey*, Christian Ell, Bernd Simon, Joerg G. Albert, Martin Keuchel, Mark E. McAlindon, Paul J. Fortun, Stefan Schumann, Jean-Louis Hugot, Vincent Yu, Udayasankar Arulmani, Gerhard Krammer, Rosemary Rebuli, Ervin Toth

M1706

Discontinuation of Lubiprostone Treatment for Irritable Bowel Syndrome with Constipation Is Not Associated with Symptom Increase or Recurrence: Results from a Randomized Withdrawal Study William D. Chey*, Richard J. Saad, Raymond M. Panas, Aimee Wahle, Ryuji Ueno

M1707

One Hour Infliximab Infusion Can Replace Two Hour Infusion in Maintenance Treatment of Crohns Disease Without Shortcomings, in Patients Treated for Up to Three Years Ragnar Befrits*, Linda Malmström, Anette Forsell, Lars-Åke Bark, Lars Blomquist

M1708

Infliximab in Hospitalized Patients with Acute Severe Ulcerative Colitis: Real Life Experience Kenneth Atkinson, Robert M. Penner, David Pearson, Brian Bressler, Nawal S. ALNahdi*, Robert A. Enns, Martin Fishman, Twila Burgmann

M1709

Proton Pump Inhibitor Based Triple Therapy Combined with Bismuth Is Superior to Proton Pump Inhibitor Based Triple Therapy Only for Helicobacter pylori Eradication. (Preliminary Data) HyunJin Jo*, Dong Ho Lee

M1710

Severity of Symptoms, Quality of Life (QOL) and Attitudes Towards Treatment in Greek Adults with Constipation George Papatheodoridis*, Ioannis Karaitianos, Jiannis Vlachogiannakos, Nikos Viazis, Demetrios G. Karamanolis

M1711

Intestinal Polyposis Prevalence in Patients with Metabolic Syndrome Javier Lizardi-Cervera, Genaro Vazquez-Elizondo*, Marisol Valdes-Escarcega, Norberto Chávez-Tapia, Misael Uribe

M1712

Interaction Between Small Intestinal Small Intestinal Motility and Absorption Following Major Abdominal Surgery Nam Q. Nguyen*, Laura Bryant, Robert Fraser, Carly Burgstad, Jim Burnett, Ross N. Butler, Richard H. Holloway

Sails Pavilion San Diego Convention Center

Sponsored by: Intestinal Disorders

CLINICAL INTESTINAL DISORDERS II Participants will be able to: • Familiarize themselves with recent clinical intestinal disorders research findings and implications. M1694



Ampullary Lesions: Incidental Adenomas Vs FAP Associated Adenomas. Results of a Single Referral Center Shayan Irani*, Andrew D. Arai, Kamran Ayub, John J. Brandabur, Russell Dorer, Margaret Farrell-Ross, Michael Gluck, Geoffrey Jiranek, David Patterson, Drew Schembre, Richard A. Kozarek

M1695



Cyclical Rifaximin for Symptomatic, Uncomplicated Diverticular Disease: A Meta-Analysis Krishna S. Kasturi*, Rajasekhara R. Mummadi, Sathya Jaganmohan

M1696



The Quality of On-Line He@lth Information in Inflammatory Bowel Disease Sander van der Marel, Herma Fidder*, Daniel W. Hommes

M1697

Lactose Malabsorption in Patients Affected By Recurrent Vaginitis Giovanna Vitale*, Marialuisa Novi, V. Cesario, Ernesto Cristiano Lauritano, E. Rinninella, M. Ainora, Giovanni Gigante, Mariachiara Campanale, M. D'Alessio, N. De Simone, S. Mancuso, Giovanni Cammarota, Giovanni Gasbarrini, Giovanni Ghirlanda, Antonio Gasbarrini



M1698

Phloroglucinol/Trimethyl Phloroglucinol (P/Tmp) Is More Effective Than Placebo to Improve Abdominal Pain During Acute Epidemic Diarrhoea: A Randomized, Double-Blind, Placebo-Controlled Trial in Primary Care Philippe R. Ducrotte*, Bruno L. Bonaz, Stanislas Bruley des Varannes, Lionel Bueno, Benoit Coffin, Olivier Chassany, Veronique Grange

M1699

Is There a Gender Bias in Surveillance for Osteoporosis in IBD Patients? A Single Center Study Punyanganie S. de Silva*, Crawford P. Jamieson

M1700

Nighttime Serum Cortisol Levels in Women with IBS Robert L. Burr, Monica Jarrett*, Sang-Eun Jun, Kevin C. Cain, Margaret Heitkemper

M1713

M1701

Gas Pattern On Lactulose Breath Test Influences Treatment Response in Patients with Small Bowel Bacterial Overgrowth Mary Elizabeth Clark*, Linda Anh B. Nguyen, Margaret Allen, Amy J. Marincek

The Relationship Between Bacterial Overgrowth, Intestinal Permeability and TNF Alpha in Pediatric Short Bowel Syndrome Conrad R. Cole*, Juliana C. Frem, Andrew T. Gewirtz, Benjamin D. Gold, Thomas R. Ziegler

M1714

M1702

A Macroscopically Normal Appendix Should Be Removed At Laparoscopy for Abdominal Pain in the Absence of An Identifiable Cause Keith Roberts*, Masoud Behravesh, Jan Dmitrewski

Incidence and Implications of Pre-Pouch Ileitis Following Restorative Proctocolectomy with Ileal PouchAnal Anastomosis Simon D. McLaughlin*, Sue K. Clark, Andrew J. Bell, Paris P. Tekkis, Paul J. Ciclitira, Ralph. J. Nicholls

M1703

Colo-Ileal Reflux and Crohn's Lesion Recurrence After Curative Ileal Resection Nadia Pallotta*, Naima Abdulkadir Hassan, Giuseppina Vincoli, Marilia Carabotti, Enrico Corazziari

M1715

M1704

What Is the Cause of Obscure Bleeding in Portal Hypertensive Patients? Filiz Akyuz*, Binnur Pinarbasi, Fatih Ermis, Ahmet Uyanikoglu, Zeynel A. Mungan

Missed Crohn's Disease Is Unlikely As a Cause of Unexplained Iron Deficiency in Pouch Patients: Evidence from Video Capsule Endoscopy Simon D. McLaughlin*, Andrew J. Bell, Aymer Postgate, Sue K. Clark, Chris H. Fraser, Paris P. Tekkis, Paul J. Ciclitira, Ralph. J. Nicholls

Denotes DDW Poster of Distinction

P-219

M O N D A Y MAY 19

POSTER SESSIONS—BASIC AGA Institute Poster Session 8:00 AM - 5:00 PM

M1728

The Enterohepatic Circulation of Bile Salts in Mice In Vivo: Effects of Essential Fatty Acid (EFA) Deficiency. Sabina Lukovac*, Frans Stellaard, Edmond H. Rings, Henkjan J. Verkade

M1729

Absence of Farnesoid X Receptor Improves Fat Absorption in Essential Fatty Acid (EFA)-Deficient Mice Sabina Lukovac*, Leonie Los, Frans Stellaard, Edmond H. Rings, Henkjan J. Verkade

M1730

Essential Fatty Acid (EFA) Deficiency in Mice Impairs Lactose Digestion Sabina Lukovac*, Leonie Los, Frans Stellaard, Edmond H. Rings, Henkjan J. Verkade

Sails Pavilion San Diego Convention Center

Sponsored by: Intestinal Disorders

INTESTINAL TRANSPORT: ABSORPTION Participants will be able to: • Evaluate recent research in absorption. M1716



Lipoxygenase Metabolites Differentially Regulate Anion Exchangers in the Chronically Inflamed Rabbit Intestine Palanikumar Manoharan, Steven Coon, Ramesh Kekuda, Vazhaikkurichi M. Rajendran, Uma Sundaram*

M1717



Molecular Mechanisms of Compensatory Regulation of Na-Glutamine Co-Transport During Chronic Intestinal Inflammation Prosenjit Saha*, Ramesh Kekuda, Subha Arthur, Jamilur R. Talukder, Uma Sundaram

M1718



LPA Stimulates NHE3 Activity via LPA5 Receptor Peijian He*, Songbai Lin, Huanchun Zhang, Dongsheng Wang, C. Chris Yun

M1719



Constitutive Nitric Oxide Regulates Na-Glucose CoTransport in Intestinal Epithelial Cells Jamilur R. Talukder*, Steven Coon, Ramesh Kekuda, Uma Sundaram

M1720

Brush Border Membrane Na-Glucose Co-Transport Regulates Na:H Exchange in Intestinal Epithelial Cells Steven Coon*, Ramesh Kekuda, Jamilur R. Talukder, Prosenjit Saha, Uma Sundaram

M1721

M O N D A Y

Role of Organic Cation Transporters (Oct1, Oct2 and Oct3) in the Uptake of the Duodenal Ulcerogen Cysteamine in Rat Duodenal Mucosa and in Rat Small Intestinal Epithelial Cell Line IEC-6: Use of SiRNA Technology Tetyana Khomenko*, John T. Pinto, Longchuan Chen, Xiaoming Deng, Ganna Tolstanova, Arthur J. Cooper, Sandor Szabo

M1722

Changes in mRNA Expression Levels of ASBT, SERT, and Octn2 in Crohn's Disease Patients Kacper A. Wojtal*, Jyrki J. Eloranta, Petr Hruz, Heike Gutmann, Jürgen Drewe, Christoph Beglinger, Gerd KullakUblick, Stephan R. Vavricka

M1723

Basal Activity of the Epithelial Brush Border Na/H Exchanger NHE3 Is Stimulated By Both PI-3K and AKTDependent and Independent Pathways Cheng Zhang*, Boyoung Cha, Mark Donowitz

M1724

MAY 19

The Apical Chloride/Base Exchanger Slc26a6 (Pat1) and the Fructose-Absorbing Transporter Slc2a5 (Glut5) Play An Essential Role in the Pathogenesis of FructoseInduced Hypertension Anurag K. Singh*, Hassane Amlal, Patrick J. Haas, Ulrike Dringenberg, Sharon Barone, Stacey Fussell, Regina Engelhardt, Zian Zuo, Ursula E. Seidler, Manoocher Soleimani

M1725



Reduced Serum Fibroblast Growth Factor 19 (FGF19) in Patients with Idiopathic Bile Acid Malabsorption Ali M. Tasleem, Tracy Dew, Sara Balesaria, Gordon W. Brydon, Carel W. Le Roux, Julian R. Walters*

M1726

Do Oxidized Plant Sterols Underlie CHD Risk in Sitosterolemia Patients? Jogchum Plat*, Elke Theuwissen, Dieter Lütjohann, Ronald P. Mensink

M1727

The Cytoprotective Effect of Ursodeoxycholic Acid Depends On Cholesterol in Cell Membranes Yong Zhou*, Rand Doyen, Lenard M. Lichtenberger

P-220

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Intestinal Disorders

INTESTINAL WOUND HEALING AND BARRIER FUNCTION Participants will be able to: • Review research in intestinal wound healing and barrier function. M1731



Sphingosine-1-Phosphate Regulates Barrier Function in Cultured Intestinal Epithelial Cells and Murine Intestinal Tissue Ruiyun Li*, Jose Greenspon, Emily Bellavance, Rex Sun, Lan Xiao, Rao N. Jaladanki, Terez Shea-Donohue, Jian-Ying Wang, Douglas J. Turner

M1732



Lipopolysaccharide (LPS) Sensitizes Bile Duct Epithelial Cells for Tight Junction (TJ) Disruption By Hydrogen Peroxide and TNFα By Nitric Oxide-Dependent Mechanism Ankur Seth*, Suneet Jain, Nicholas F. LaRusso, Radhakrishna (RK) Rao

M1733

Protective Effect of Rebamipide On the MethotrexateInduced Intestinal Dysfunction in Rats Kazuma Hamada*, Yoshihisa Shitara, Shuichi Sekine, Toshiharu Horie

M1734

Intestinal Involvement in Autistic Disorder: Progress of Research Valeria Familiari*, Laura de Magistris, Anna Sapone, Gabriele Riegler, Maria Cartenì, Patrizia Iardino, Giancarlo Caravelli, Carmela Bravaccio, Alessandro Frolli, Roberto Militerni, Antonio Pascotto

M1735

Glycine and Glutamine Reduce Permeability of Human Colonic Epithelial Cell Monolayers By Selectively DownRegulating Claudin-2 Expression Xianzhi Zhang*, Tatsuro Katsuno, Toru Sato, Tomoo Nakagawa, Yoshiko Kawasaki, Yasushi Saito

M1736

Intestinal Permeability in Migraineurs Emidio Scarpellini*, Diana Ferraro, Cristiano Lauritano, Lucia Sparano, Chiara Campanale, Giovanni Gasbarrini, Giovanni Ghirlanda, Girolamo Di Trapani, Venanzio Valenza, Antonio Gasbarrini

M1737

Lactobacillus GG Prevent Impaired Barrier Function in Intestinal Epithelial Cells Chang Soo Eun*, Dong Soo Han, Hyun Seok Cho, Tae Jun Byun, Tae Yeob Kim, Yong Cheol Jeon, Joo Hyun Sohn

M1738

The Changes of Non-Steroidal Anti-Inflammatory Drugs (NSIADs) Induced Gut Damage, Enteric Bacterial Numbers and Bacterial Translocation with Time After Administration of NSIADs Jeong Wook Kim*, Woo Kyu Jeon, Jae G. Kim

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC M1739

Dietary Calcium Decreases But Fructo-Oligosaccharides Increase Intestinal Permeability in Colon of Rats Marloes Schepens*, Arjan Schonewille, Carolien Vink, Robert-Jan Brummer, Roelof Van Der Meer, Ingeborg BoveeOudenhoven

M1740

Efficacy of Sucralfate Enema in Solitary Rectal Ulcer Syndrome Hamid Tavakkoli*, Monireh Tavakkoli, Peyman Adibi, Mohammad Hasan Emami, Parvin Mahzouni, Farnaz Farshidfar

M1741

Bioactive Glass Stimulates Intestinal Epithelial Cell Restitution Syed R. Moosvi*, Richard M. Day

M1741a

SRC Kinase-Dependent MLCK Activation Mediates Tight Junction (TJ) Disruption By Hydrogen Peroxide and TNFα in Bile Duct Epithelium Ankur Seth*, Srikar Guntaka, Nicholas F. LaRusso, Jerrold R. Turner, Radhakrishna (RK) Rao



AGA Institute Poster Session 8:00 AM - 5:00 PM

M1750

Pooled Analysis of Primary Prophylaxis for Spontaneous Bacterial Peritonitis At 6 Months Nadim S. Jafri*, Yasser H. Shaib

M1751

The Lipid Lowering Agents Atorvastatin and Rosuvastatin Have No Protective Effect On Thioacetamide Induced Liver Cirrhosis in Rats Haim Shirin*, Hussain Aeed, Dov Gavish, Svetlana Gregoriev, Mark Shahmurov, Zipora Matas, Yona Avni, Rafael Bruck

M1752

Common Variants in the NOD2 Gene Are Associated with IL-8 Levels in Patients with Advanced Liver Disease - a Prospective Single Center Survival Study Frank Grünhage*, Bettina Rezori, Ulrich Spengler, Tilman Sauerbruch, Frank Lammert, Christoph Reichel

M1753

Does Portal Decompression with Transjugular Intrahepatic Portosystemic Shunt in Cirrhotics Improve Thrombocytopenia? Muhammad A. Asim*, Saad M. Khan, Muhammad Bilal, Satheesh Nair, Ian T. Gaillard

M1754

Mortality and Predictors of Prognosis in Culture Positive Spontaneous Bacterial Peritonitis and Culture Negative Neutrocytic Ascites Khalid Mumtaz, Lubna Kamani*, Saeed S. Hamid, Wasim Jafri

M1755

Methotrexate-Induced Hepatotoxicity in Rheumatoid Arthritis Rasoul Sotoudehmanesh*, Bita Anvari, Masoumeh Akhlaghi, Shadi Shahraeeni, Morteza Khatibian, Javad Mikaeli, Reza Ansari, Hossein Asle-Soleimani

M1756



Novel Immunologic Finding As One of the Probable Causes of Spontaneous Bacterial Peritonitis in Patients with Cirrhosis Sagrario D. Contreras-Contreras, Cecilia M. Guillen-Vargas, Laura E. Moreno-Luna*, Jorge E. Segura-Ortega, Mary Fafutis-Morris

M1757

Predictors of Mortality Due to Pyogenic Liver Abscesses: An Analysis of US Hospitalizations from 1998 to 2004 Liisa Meddings, Robert P. Myers, Abdel Aziz M. Shaheen, Kevin Laupland, James Hubbard, Gilaad G. Kaplan*

M1758

Admission and 48 Hours Serum Creatinine As a Risk Factor for Failure to Control Bleeding and in Hospital Mortality in Child C Patients with Variceal Bleeding Ricardo Flores Rendon*, Rafael Castañeda-Sepulveda, Susana Galindo Marines, Diego Garcia-Compean, Hector J. Maldonado, Jose A Gonzalez

Sails Pavilion San Diego Convention Center

Sponsored by: Liver & Biliary

COMPLICATIONS OF LIVER DISEASE Participants will be able to: • Be aware of the advances in our understanding and approaches to the complications of liver disease. M1742

Deleterious Effect of Cirrhosis On Outcomes After Motor Vehicle Crashes Using the Nationwide Inpatient Sample Jasmohan S. Bajaj*, Ashwin N. Ananthakrishnan, Raymond G. Hoffmann, Emily L. McGinley, Karen Brasel

M1743

Outpatient Proton Pump Inhibitor Use Does Not Affect Outcomes After Variceal Bleeding Jasmohan S. Bajaj*, Yelena Zadvornova, Kia Saeian

M1744

Health-Related Quality of Life in Men with Liver Cirrhosis: The Impact of Low Testosterone Evangelos Kalaitzakis*, Axel Josefsson, Einar Bjornsson

M1745

M1746



M1747

Morbidity and Mortality of TIPS Placement in the Elderly Is No Different Than in Younger Age Groups Neehar Parikh*, Andres T. Blei, Steven L. Flamm Toll-Like Receptor 4-Mediated Immune Response Is Required for In Vivo Eradication of C. Parvum Infection of the Biliary Tract Pamela S. Bogert*, Steven P. O'Hara, Christy E. Trussoni, Angela J. Stroope, Jason T. Lewis, XianMing Chen, Nicholas F. LaRusso IGF-1 Vs Rifaximine for Hepatic Encephalopathy Treatment in Ascitic Cirrhotic Rats with Total Portal Vein Ligation Mireia Miquel*, Gemma Odena, Ramon Bartoli, Anna Serafin, Amparo Galan, Ramon Planas

M1748

Vitamin D Deficiency in Consecutive Patients with Chronic Liver Disease Anita Narshi, Sabina S. Beg, Christine Blanshard, Anne Ballinger*

M1749

Cerebral and Retrobulbar-Ocular Hemodynamic Study Assessed By Color Doppler Ultrasonography in Cirrhotic Patients M. Serricchio*, Ernesto Cristiano Lauritano, Marialuisa Novi, Antonio Laginestra, Michele Santoro, Rosalba Finizio, Maria Assunta Zocco, A. Piscaglia, Francesca Fiore, Giovanni Ghirlanda, Antonio Gasbarrini



AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

MAY 19

Sponsored by: Liver & Biliary

METABOLIC AND GENETIC LIVER DISEASE, INCLUDING NAFLD Participants will be able to: • Learn about metabolic liver disease; learn about genetic liver disease; and better comprehend the basis for and management of fatty liver diseases. M1759

Efficacy of Dimethylacetothetin, An Analog of Betaine, in the Treatment of Alcoholic Liver Injury Brian W. Ward*, Jonathan Meyer, Dean J. Tuma, Kusum K. Kharbanda, Martin Hulce

Denotes DDW Poster of Distinction

M O N D A Y

P-221

POSTER SESSIONS—BASIC M1760

Bifidobacteria Attenuate the Development of NonAlcoholic Fatty Liver in Obese Mice Ahmed A. Abu-Shanab*, Eileen F. Murphy, Erin L. Symonds, Mohammed T. Badr, Liam O'Mahony, Fergus Shanahan, Brendan M. Buckley, Eamonn M. Quigley

M1772

The Use of Liver Ultrasound and Liver Enzymes in Detecting Non-Alcolohlic Fatty Liver Disease in Obese Children Hernando Lyons*, Hannan Alsahlani, Alice Foster, Saleem Raza, Amina Husain, Rajam Samudrala, Karen Hagglund

M1761



MicroRNA-15a Post-Transcriptionaly Regulates Expression of the Cell Cycle Regulator, Cdc25a, Affecting Cholangiocyte Proliferation and Cyst Growth in the PCK Rat, An Animal Model of Autosomal Recessive Polycystic Kidney Disease (ARPKD) Tatyana V. Masyuk*, Seung-Ok Lee, Patrick L. Splinter, Anatoliy I. Masyuk, Angela J. Stroope, Nicholas F. LaRusso

M1773



P2Y12 and the Components of the AKAP-Signaling Complex Are Localized to Cholangiocyte Cilia Providing Chemosensory Functions of These Organelles Anatoliy I. Masyuk*, Jesus M. Banales, Sergio A. Gradilone, Tatyana V. Masyuk, Bing Q. Huang, Angela J. Stroope, Nicholas F. LaRusso

M1774

M1762

Oxidative Stress Alters Survival and Insulin-Related Pathways Inducing Damage in HEPG2 Cells Anna Alisi, Fiorella Piemonte, Matilde Marcellini, Laura Gaeta, Rodolfo Fruhwirth, Melania Manco, Valerio Nobili*

The Role of Th1 Immunity in Promoting Cholesterol Gallstone Formation in C57BL/6J Mice Kirk J. Maurer*, Martin C. Carey, James G. Fox

M1763

Differential Effects of Alcohol and Homocysteine On ER Stress Signaling and Liver Injury Between Mice and Rats Masao Shinohara*, TinAung Than, Christine Chan, Neil Kaplowitz, Cheng Ji

M1764

M1765

M O N D A Y MAY 19

Epidemiology of Non-Alcoholic Fatty Liver Disease (NAFLD) Among Adults in An Urban Sri Lankan Community A. S. Dassanayake*, S. Rajindrajith, A. Kasthurirathne, U. Kalubowila, A. P. De Silva, T. Mizoue, M. Makaya, H. J. de Silva



Hepatocyte Specific PIK3CA Transgenic Mice Develop Steatohepatitis and Hepatocellular Carcinoma Yotaro Kudo*, Yasuo Tanaka, Shin Maeda, Motohisa Tada, Motoko Seto, Yoshinari Asaoka, Miki Ohta, Fumihiko Kanai, Haruhiko Yoshida, Takao Kawabe, Masao Omata

M1766

Waist Circumference Correlates with Hepatic Fat Accumulation in Male Japanese Patients with Nonalcoholic Fatty Liver Disease, But Not in Females Noriko Oza*, Yuichiro Eguchi, Eriko Ishibashi, Takahisa Eguchi, Shunya Nakashita, Yoichiro Kitajima, Shigetaka Kuroki, Iwata Ozaki, Yasunori Kawaguchi, Yasushi Ide, Tsutomu Yasutake, Ryuichi Iwakiri, Toshihiko Mizuta, Naofumi Ono, Kazuma Fujimoto

M1767

Effect of Oral Supplement of Whey Protein Isolate On Nonalcoholic Fatty Liver Disease Taned Chitapanarux*, Prasong Tienboon, Sawalee Pojchamarnwiputh, Donrawee Leelarungrayub

M1768

FXR Induces Liver Hypertrophy Through the Homeobox Factor Hex Xiangbin Xing*, Elke Burgermeister, Christoph Röcken, Matthew Wright, Martin Ebeling, Roland M. Schmid, Matthias Ebert

M1769

Betaine Treatment Reverses Insulin Resistance and Fatty Liver Disease Without Reducing Oxidative Stress or Endoplasmic Reticulum Stress in An Animal Model of NAFLD Gitte Borgschulte,*, Elango Kathirvel, Marisse Herrera, Samuel W. French, Timothy R. Morgan, Kengathevy Morgan, Teodoro Bottiglieri

M1770

Serum Retinol-Binding Protein 4 (RBP4) Levels in Patients with Nonalcoholic Fatty Liver Disease Naim Alkhouri*, Ariel E. Feldstein, Michael P. Berk

M1771

The Prevalence of Insulin Resistance in Patients with Chronic Hepatitis C and B Wael Soliman*, Magdalena Kuczynski, I.George Fantus, Jenny Heathcote

P-222

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility

FGD: PSYCHOSOCIAL AND PSYCHOTHERAPEUTIC Participants will be able to: • Evaluate research in FGD: Psychosocial and psychotherapeutic. M1775

Increased Physical Activity Improves GI-Symptoms But Not Fatigue and Depression in the Irritable Bowel Syndrome (IBS) Elisabet Morlin*, Magnus Simren, Hans Strid, Riadh Sadik

M1776



Images of Disease: A Study in Irritable Bowel Syndrome and the Effect of Treatment Helen R. Carruthers*, Vivien Miller, Nicholas Tarrier, Peter J. Whorwell

M1777

Exploration of the Sympatho-Vagal Balance in IBD and IBS Patients Sonia Pellissier*, Cecile Dantzer, Nicolas Mathieu, Bruno L. Bonaz

M1778

Determinants of Weight Loss in Functional Dyspepsia: A Different Role for Gastric Sensorimotor Dysfunction, Psychosocial Factors & Somatization in Hyper and Normosensitive Patients Lukas Van Oudenhove*, Joris U. Vandenberghe, Brecht Geeraerts, Rita Vos, Koen Demyttenaere, Benjamin Fischler, Jan F. Tack

M1779



Both Bowel Symptom Severity and Visceral Anxiety Are Major Determinants of the Quality of Life Impact of Constipation Olafur S. Palsson*, Bruce D. Naliboff, Marsha J. Turner, Rona L. Levy, Andrew D. Feld, Michael Von Korff, William E. Whitehead

M1780

Positive Association Between Intimate Partner Violence and Irritable Bowel Syndrome in Latina Women: A Population-Based Study in Nicaragua Sylvia I. Becker-Dreps, Eliette Valladares, Rodolfo Pena, Loreto Cortes, Christopher Martin, Douglas R. Morgan*

M1781

Patients Suffering from Irritable Bowel Syndrome Do Have Alterations of the Serotonin-Metabolism, Which Are Independent from Psychiatric Comorbidities Marco Schmidtmann*, Julius Büchner, Andrea Riedl, Ivo R. van der Voort, Peter Kobelt, Hubert Mönnikes

M1782

Does IBS Exist Without Psychosocial Distress and Somatization? Rok Seon Choung*, G. Richard Locke, Cathy Schleck, Alan R. Zinsmeister, Nicholas J. Talley

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC M1783

The Relative Effects of Clinical and Psychosocial Factors On Health Care Utilization and Disability in Women with Functional Bowel Disorders Denesh K. Chitkara*, Carolyn B. Morris, Yuming J. Hu, Brenda B. Toner, Nicholas E. Diamant, Jane Leserman, Christine B. Dalton, Shrikant I. Bangdiwala, William E. Whitehead, Douglas A. Drossman

M1793

Abnormalities in Nerves and Pacemaker Cells in Children with Functional Constipation Bridget R. Southwell*, Sebastian K. King, Jonathan Sutcliffe, Pam Farmer, John M. Hutson

M1794

How Well Does Stool Form and Stool Frequency Correlate with Colonic and Whole Gut Transit in Healthy Controls and Constipated Patients? Richard J. Saad*, William D. Chey, Satish S. Rao, William L. Hasler, Leonard A. Katz, Kenneth L. Koch, Braden Kuo, Jeffrey M. Lackner, Henry P. Parkman, Richard McCallum, Carrie Miller, Irene Sarosiek, Jack Semler, Michael D. Sitrin, Gregory E. Wilding

M1784

Is Sexual and Physical Abuse in Irritable Bowel Syndrome (IBS) Related to An Impaired Health-Related Quality of Life? Jose M. Remes-Troche*, Max J. Schmulson, Silvia CidJuarez, Antonio Ramos-de-la-Medina, Federico B. Roesch

M1785

Relationship Between Pain Beliefs, Stress Perception and Symptom Severity in Irritable Bowel Syndrome Mary-Joan Gerson*, Charles Gerson

M1795

Double Blind, Placebo Controlled Study of the Oral Capsaicin Test in Patients with Functional Dyspepsia Martina Führer*, Harald Vogelsang, Johann Hammer

M1786

How Does the Oral Capsaicin Test Correlate with Psychological Morbidity and Quality of Life in Patients with Functional Dyspepsia and Organic Disease? Martina Führer*, Harald Vogelsang, Johann Hammer

M1796

M1787

Gastrointestinal Symptoms That Differentiate Pediatric FD from IBS Shelby Langer*, Lynn S. Walker, Kari F. Baber, William E. Whitehead, Joan Romano, Dennis L. Christie, Nader N. Youssef, Sheri A. Ballard, Melissa Young, Melissa J. Coffey, Sharon Brenner, Lila Garner, Rona L. Levy

Long-Term Follow Up of a Previous Double Masked Temporary GES Study: The Importance of Baseline Physiologic Measures John M. Runnels*, Ernest S. Weeks, William Johnson, Thomas L. Abell

M1797

Functional Digestive Disorders: Intuitive Diagnosis Versus ROME II Criteria Agustin Balboa*, Fermin Mearin, Jose Luis Calleja

M1798

Bloating and Distension Across the Menstrual Cycle in Irritable Bowel Syndrome (IBS): Effect of Bowel Habit Anurag Agrawal*, Peter J. Whorwell, Lesley A. Houghton

M1799

The ROME III Questionnaire Functional Constipation Module As a Constipation Severity Scale Olafur S. Palsson*, Marsha J. Turner, Rona L. Levy, Andrew D. Feld, Michael Von Korff, Douglas A. Drossman, William E. Whitehead

M1800

Persistence of the ROME Diagnostic Symptoms for Irritable Bowel Syndrome Olafur S. Palsson*, Miranda A. Van Tilburg, Motoyori Kanazawa, Denesh K. Chitkara, Lisa M. Gangarosa, Douglas A. Drossman, William E. Whitehead

M1801

Prevalence and Impact of Irritable Bowel Symptoms in the Belgian General Population Hubert Piessevaux*, Benjamin Fischler, Jan F. Tack

M1802

Herbal Preparation STW 5 Improved Quality of Life in Patients with Functional Dyspepsia - Results of a Placebo-Controlled Trial Ahmed Madisch*, Ulrike von Arnim, Jürgen Müller, Bettina R. Vinson, Karin Zeller, Peter Malfertheiner

M1788

M1789

Effect of Therapeutic Guideline On Irritable Bowel Syndrome: A Randomized Controlled Trial Shin Fukudo*, Michio Hongo, Tooru Shimosegawa, Daisuke Sasaki, Kei Matsueda, Shigeru Harasawa, Soichiro Miura, Tetsuya Mine, Hiroshi Kaneko, Tetsuo Arakawa, Ken Haruma, Akira Torii, Takeshi Azuma, Hiroto Miwa, Takayuki Matsumoto, Mikihiko Fukunaga, Masanori Handa, Yoshikazu Kinoshita, Toshikatsu Okumura, Takeshi Miwa, IBS Club Impact of Irritable Bowel Syndrome On Depressive Disorder Tomotaka Shoji*, Shin Fukudo, Daisaku Tamura, Yuko Kimura, Masashi Adachi, Yuka Endo, Yasuhiro Sagami, Jou Morishita, Tomomi Machida, Takatsugu Machida, Michio Hongo

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility

FUNCTIONAL GD: EPIDEMIOLOGY AND SYMPTOMS

M1803

Participants will be able to: • Understand the epidemiology and symptoms associated with FGD. M1790

M1791

M1792

National Health and Nutrition Examination Survey (NHANES) of Stool Frequency and Consistency in U.S. Adults William E. Whitehead Dietary Intake of Tryptophan in IBS Patients Raquel García Sánchez*, Mónica García Alonso, Enrique Rey, Cristina Almansa, Angel Alvarez Sanchez, Manuel Diaz Rubio Self-Reported Milk Intolerance and Symptomatic Lactose Malabsorption: Differential Diagnosis or Manifestation of the Irritable Bowel Syndrome? Viola Andresen*, Jan-Malte Ambs, Jutta Keller, Peter H. Layer

Herbal Preparation STW 5 Significantly Improved Concomitant Reflux Symptoms in Patients with Functional Dyspepsia- a Subgroup Analysis of PlaceboControlled Trials Ahmed Madisch*, Mario H. Mueller, Bettina R. Vinson, Dieter Weiser

M1804

Pharmacist Attitudes About Constipation and Its Treatment: A Survey Conducted in Three Countries Michael A. Kamm, Carmelo Scarpignato, Stefan A. MuellerLissner, Arnold Wald, Ulrika Hinkel, Chris Schuijt, Kenneth G. Mandel*

M1805

Defining, Diagnosing and Treating Constipation: Attitudes Among Gastroenterologists and General Practitioners - Results of a Three Country Survey Michael A. Kamm, Carmelo Scarpignato, Stefan A. MuellerLissner, Arnold Wald, Ulrika Hinkel, Chris Schuijt, Kenneth G. Mandel*

Denotes DDW Poster of Distinction

P-223

M O N D A Y MAY 19

POSTER SESSIONS—BASIC M1806

Complaints Suggestive of Irritable Bowel Syndrome Are Common in Patients with Puborectalis Dyssynergia: An Under-Recognized Overlap Syndrome Amol S. Rangnekar*, Daniel Morgan, Paul Knechtges, Richard J. Saad, Dee Fenner, Arden M. Morris, William D. Chey

M1820

A Comparison of Disease Impacts On Quality of Life Between Inflammatory Bowel Disease and Irritable Bowel Syndrome Sang Joong Kim, Chang Hwan Choi*, Jang Sik Mun, Hong Ju Moon, Hyun Woong Lee, Hyung Joon Kim, Jae Hyuk Do, Sae Kyung Chang

M1807

Anorectal and Bowel Syndromes in Fibromyalgia: Results of a Survey Using ROME II Criteria in the Spanish Population Cristina Almansa*, Enrique Rey, Monica O. Garcia Alonso, Raquel Garcia Sanchez, Angel Alvarez Sanchez, Manuel Diaz-Rubio

M1821

Vulvodynia in the Gastroenterology Clinic: Assessment of Prevalence and Associated Gastrointestinal Symptoms Sarah Umar*, Lucinda A. Harris, Sailajah Janarthanan, Tisha N. Lunsford, Michael P. Jones, Michael D. Crowell

M1808

Making IBS a “Diagnosis of Inclusion”: Development of a New Diagnostic Criteria for IBS Kimberly Low*, Laura J. Hwang, Ara Sahakian, Janet Yang, Sheila Lezcano, Eric A. Vasiliauskas, Andrew Ippoliti, Patricio Ibanez, Mark Pimentel

M1809

M1810

Prevalence of Functional Gastrointestinal Disorders in Patients with Ineffective Esophageal Motility Horst G. Haack, Ross D. Hansen*, John E. Kellow

M1811

Factor Analysis Demonstrates a Symptom Cluster Related to Methane Production in Irritable Bowel Syndrome (IBS) Marc D. Makhani*, Janet Yang, James M. Mirocha, Kimberly Low, Mark Pimentel

M1812

M O N D A Y MAY 19

What Drives Health-Care Utilization in Patients with Functional Dyspepsia (FD) in a Tertiary Referral Center? Sebastian Haag*, Wolfgang Senf, Sefik Tagay, Guido Gerken, Nicholas J. Talley, Gerald J. Holtmann

Are Rectal Hypersensitivity and Compliance Associated to Symptoms in IBS Patients? Mónica García Alonso*, Enrique Rey, Raquel García Sánchez, Cristina Almansa, Angel Alvarez Sanchez, Manuel Diaz-Rubio

M1813

Incidence,Etiology and Management of Rapid Gastric Emptying At An Academic Motility Center Harshal R. Patil*, Savio Reddymasu, Teri H. Lavenbarg, Pernilla k. Foran, Richard McCallum

M1814

The Use of ‘Red Flags' and Colonoscopy in the Diagnosis of Irritable Bowel Syndrome in Clinical Practice Brian Hyett*, Priya M. Roy, Daniel A. Leffler, Anthony Lembo

M1815

More Than Just GERD: Obstructive Sleep Apnea Is Associated with IBS and Constipation Wendy A. Mikulski*, David Anjelly, Radha V. Menon, James C. Reynolds, Joanne Getsy, Irvin Tantuco, Michel Alkhalil, Asyia S. Ahmad

M1816

What Patients with Functional Digestive Disorders Complain About? Fermin Mearin*, Agustin Balboa, Jose Luis Calleja

M1817

Irritable Bowel Syndrome Is Stronger Than Bronchial Reactivity As a Predictor of Asthma Symptoms Joseph Zimmerman*, Eran Lavi, Neville Berkman

M1818

To ER Is Human: Emergency Room Use in Cyclic Vomiting Syndrome Thangam Venkatesan*, Sally Tarbell, Kathleen Adams, Trish Barribeau, Jennifer McKanry, Kathleen R. Beckmann, B. U. Li

M1819

P-224

Low Self-Efficacy Affects Symptoms and Quality of Life in Adolescents with Irritable Bowel Syndrome Yuka Endo*, Yuko Kimura, Shin Fukudo, Tomotaka Shoji, Yasuhiro Sagami, Jou Morishita, Tomomi Machida, Takatsugu Machida, Motoyori Kanazawa, Michio Hongo

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Nutrition & Obesity

SHORT BOWEL SYNDROME Participants will be able to: • Learn more about basic and clinical research on the pathogenesis and management of short bowel syndrome. M1822

Mapping the Changes in Epithelial Crypt Populations Following Massive Small Bowel Resection: A Unique Histological Study in a Piglet Model of Short Bowel Syndrome Prue M. Pereira-Fantini*, Sarah Thomas, Russell Taylor, Magdy Sourial, Peter J. Fuller, Julie E. BInes

M1823

Synergistic Intestinal Growth in Parenterally-Fed Rats Given Supplemental Enteral Nutrients (SEN) and a LowDose of GLP-2 Is Correlated with Greater Proglucagon and IGF-I Expression in Ileum Xiaowen Liu*, Sangita G. Murali, Jens J. Holst, Denise M. Ney

M1824

Morphologic and Functional Intestinal Adaptation Following Massive Resection Is Altered in TIS7 Transgenic and TIS7-/- Mice Carrie C. Coughlin*, Shujun Jiang, Cong Yu, Lihua Wang, Elzbieta A. Swietlicki, Anisa Shaker, Christopher Rowley, Lukas A. Huber, Ilja Vietor, Marc S. Levin, Deborah C. Rubin

M1824a

Two Dose-Equivalent, 56-Days, Subcutaneous (s.c.), Glucagon-Like Peptide 2 (GLP-2) Regimens, 1.6 Mg Once Daily (OD) Versus 0.4 Mg Four Times Daily (QID), in the Treatment of Short Bowel Syndrome (SBS) Patients Palle B. Jeppesen*, Ida B. Gottschalck, Jens J. Holst, Per B. Mortensen



M1824b Improvements in Renal Function in Short Bowel Syndrome (SBS) Patients Treated for Two Years with Subcutaneous Native Glucagon-Like Peptide 2 (GLP-2) Palle B. Jeppesen*, Ida B. Gottschalck, Jens J. Holst, Per B. Mortensen

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Pancreatic Disorders

EXPERIMENTAL PANCREATITIS I Participants will be able to: • Understand the pathophysiology of pancreatic diseases. M1825



Proteomics Analysis of Rough Endoplasmic Reticulum (RER) from Normal and Acute Pancreatitis Rat Pancreas Xuequn Chen*, Maria Dolors Sans, Nancy L. Vogel, Philip C. Andrews, John A. Williams

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC M1827



NF-kB Activation in Myeloid Cells Contributes to Local and Systemic Complications in Acute Pancreatitis Hana Algül*, Marina Lesina, Matthias Treiber, Karen Dlubatz, Nico van Rooijen, Roland M. Schmid

M1828

Autophagy Impairment Mediates Vacuolization and Trypsinogen Activation in Experimental Pancreatitis Olga A. Mareninova*, Kip Hermann, Stephen J. Pandol, Paul Webster, Samuel W. French, Fred S. Gorelick, Ilya Gukovsky, Anna S. Gukovskaya



M1829

Proinflammatory Effects of Hydrogen Sulfide On Substance P in Caerulein-Induced Acute Pancreatitis Madhav Bhatia*, Jenab Sidhapuriwala

M1830

Protein Domains of Pancreatitis Associated Protein 2 (PAP2) Which Are Critical for Activity Domenico Viterbo*, Martin Bluth, Cathy M. Mueller, Raj Wadgaonkar, Michael E. Zenilman

M1831

Calpain-Mediated Breakdown of Cytoskeletal Proteins Contributes to Disassembly of the Actin Cytoskeleton in Rat Pancreatic Acinar Cells During Acute Pancreatitis Heike Weber*, Saskia Hühns, Frank Lüthen, Ludwig Jonas

M1832

Autophagy Mediated By VMP1 Expression Is a Survival Mechanism in Caerulein-Treated AR42J Pancreas Cells Maria L. Sacchetti, Daniel Grasso, Andrea E. Lo Ré, Romina P. Pardo, Juan L. Iovanna, Alejandro Ropolo, Maria I. Vaccaro*

M1833

M1834

M1835

M1836

Increased Expression of SMAD6 Deteriorates Murine Acute Pancreatitis Hayato Nakamura*, Hiroshi Asaumi, Yoko Nomiyama, Shiro Watanabe, Makoto Otsuki Reduction of Inflammation and Chronic Tissue Damage By Omega-3 Fatty Acids in Chemically Induced Pancreatitis Karsten H. Weylandt*, Anja Nadolny, Lena Kahlke, Gregory Y. Lauwers, Jonathan Glickman, Jing X. Kang Pancreatic Necrosis Associated with Caerulein-Induced Pancreatitis Is Attenuated in α2-Antiplasmin-Deficient Mice Shumpei Satoi*, Yoshifumi Takeyama, Harumasa Ohyanagi, Kiyotaka Okada, Osamu Matsuo Acute Experimental Pancreatitis Is Ameliorated By Activation of Cannabinoid-1 (CB1) Receptors Martin Storr*, Johannes Kramer, Thomas Michler, Antje Malo, Burkhard Göke, Claus Schaefer

M1837

Increased Severity of Arginine Induced Pancreatitis Is Reflected By Differential Pancreatic Gene Expression Sebastian Gaiser*, Constanze Kubisch, Baoan Ji, Craig D. Logsdon

M1838

Up-Regulation of Hemoxygenase-1 Provides a Novel Therapeutic Approach in Early Acute Experimental Pancreatitis Aida Habtezion*, Raymond Kwan, Eugene Butcher, Ehsaan Akhtar, Hui Ye Zheng, Stephen P. Wanaski, Stephen M. Collins, Bishr Omary

M1839

Risperidone Ameliorates Not Only Mild But Also Severe Acute Pancreatitis By Inhibiting Inflammatory Responses in Mice: A Possible New Therapy for Acute Pancreatitis Kentaro Hamada*, Hiroyuki Isayama, Yoshiki Yagi, Shuichi Kanazashi, Koji Takeuchi, Isamu Yamaguchi

M1840

Detection and Identification of Bacterial DNA in Jejunal Liquid and Blood from Patients with Acute Pancreatitis As Evidence of Bacterial Traslocation: Preliminary Results Enrique de-Madaria*, María Dolores Picó, Juan Martínez, Rubén Francés, María Adelina Gimeno, Antonia SánchezBautista, Paula Giménez, Laura Sempere, Gema Soler, Joaquín A. Plazas, José Such, Miguel Pérez-Mateo

M1841

A pH-Sensitive, Neurogenic Pathway Mediates Disease Severity in a Model of Post-ERCP Pancreatitis Marc D. Noble, Joelle Romac, Rodger A. Liddle*

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Nutrition & Obesity

NUTRIENTS AND GUT FUNCTION: CELL SIGNALING, IMMUNITY AND GENE EXPRESSION Participants will be able to: • Review novel research in the effects of nutrients on gut function including cell signaling, immunity and gene expression. M1841a



Phylogenetic Analysis and Examination of Evolutionary Conservation of GIP Expression Michelle C. Musson*, Lisa I. Jepeal, Patrick D. Mabray, Irina V. Zhdanova, M. Michael Wolfe

M1841b The Folate Transporters SLC46A1 and Slc19a1 Exhibit Differential Expression in Intestinal Epithelial Cells in Response to Iron Deficiency Kwo-Yih Yeh*, Mary Yeh, Laura Mims, Jonathan Glass



M1841c

Glutamine Deprived Diet Induces the Colonic Hemorrhage and Influences the Cell Cycle of the Colonic Epithelium in New Born Mice Takayuki Motoki*, Yoshio Naomoto, Junji Hoshiba, Nobuyuki Watanabe, Toshio Nishikawa, Munenori Takaoka, Yasuhiro Shirakawa, Tomoki Yamatsuji, Minoru Haisa, Junji Matsuoka, Noriaki Tanaka

M1841d Crohn's Disease a State of Adiponectin Resistance Razvan I. Arsenescu*, Violeta Arsenescu, Houssam E. Mardini, Deborah R. Flomenhoft, Willem J. de Villiers M1841e

The Role of Alternatively Activated Macrophages (AAMΦ) in Intestinal Epithelial Cell Responses to Enteric Nematode Infection Diana C. Riera*, Rex Sun, Aiping Zhao, Jennifer A. Stiltz, Joseph F. Urban, Terez Shea-Donohue

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION I: BASIC / BILIARY M1842

CD44-Hyaluronan Interaction Plays a Critical Role in Biliary Proliferation During the Development of Hepatic Cholestasis Gordon D. Wu*, Yao He, Haimei Wang, Hong Wang, John M. Vierling, Andrew S. Klein

Denotes DDW Poster of Distinction

P-225

M O N D A Y MAY 19

POSTER SESSIONS—BASIC SSAT Poster Session 8:00 AM - 5:00 PM

M1853

Sails Pavilion San Diego Convention Center



Simultaneous Splenectomy Enhance Liver Regeneration After Major Hepatectomy Via Decreasing Activin-A Expression Yan-Shen Shan*, Pin-Wen Lin

SSAT POSTER SESSION I: BASIC / COLON-RECTAL M1843

Decreased PLD2 Expression Correlates with NM404 Retention in Human Colorectal Cancer Xenografts Joseph Nwankwo*, Jaime H. McCord, Mary Wentworth, Jamey Weichert, Sharon M. Weber

M1844

The Effects of Dai-Kenchu-to (Tu-100) On Propulsive Motility in the Colon Michael Wood*, Neil H. Hyman, Gary M. Mawe

M1845



Effect of NOD2/CARD15 Mutations On Ileal Gene Expression Profiles in Crohn's Disease Casey K. McCullough, Christina M. Hamm, Elizabeth Gorbe, Jonathan T. Unkart, Ellen Li, Qing qing Gong, Candace R. Miller, Thaddeus S. Stappenbeck, Christian Stone, David W. Dietz, Steven R. Hunt*

M1847

The Effect of Toll Like Receptor (TLR) 9 Agonist, CpG Oligodeoxynucleotides (ODN), On Abdominal and Gastrotomy Wound Healing in a Murine Model Ik-Yong Kim*, Xiaohong Yan, Raymond Baxter, Thomas R. Gardner, Chandana Shantha Kumara HM, Aqeel Ahmed, Carlos Cordon-Cardo, Richard L. Whelan

SSAT Poster Session 8:00 AM - 5:00 PM

SSAT Poster Session 8:00 AM - 5:00 PM

SSAT POSTER SESSION I: BASIC / PANCREAS M1854

Cannabinoid Receptor Blockade Attenuates Acute Pancreatitis By An Adiponectin Mediated Mechanism Nicholas J. Zyromski*, Abhishek Mathur, Terence Wade, Sue Wang, Deborah A. Swartz-Basile, Andrew Prather, Keith D. Lillemoe, Henry A. Pitt

M1855

Over-Expression of Focal Adhesion Kinase Inhibits Cell Proliferation in Gastrointestinal Neuroendocrine Tumor Cells Li Ning*, Muthusamy Kunnimalaiyaan, Herbert Chen

M1856



Potential Therapeutic Targets in Invasive Pancreatic Cancer Identified By Gene Expression Profiling Annamarie Rogers*, Joseph Murphy, Ellen Manahan, Desmond P. Toomey, Kevin C. Conlon

M1857

A Xenograft Model and Cell Line Deriving from Invasive Intraductal Papillary Mucinous Neoplasm of the Pancreas Stefan Fritz*, Carlos Fernandez-del Castillo, A. John Iafrate, Mari Mino-Kenudson, Nancy L. Neyhard, Jennifer LaFemina, Amy Stirman, Andrew L. Warshaw, Sarah P. Thayer

M1858

pp32 Is a Key Regulator of Cellular Differentiation: Implications for Anti-Cancer Therapy Jonathan R. Brody, Timothy K. Williams*, Agnes Witkiewicz, Joseph Cozzitorto, Gary Pasternack, Shrihari Kadkol, Charles J. Yeo

M1859

The Effect of ras/raf-1 Pathway Activation On Somatostatin Receptors in Gastrointestinal Carcinoid Tumor Cells Scott N. Pinchot*, Herbert Chen

M1860

Pterostilbene Inhibits Pancreatic Cancer In Vitro Julie A. Alosi*, Debbie E. McDonald, David W. McFadden

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION I: BASIC / ESOPHAGEAL M1848

M1849



M O N D A Y MAY 19

M1850

Evaluation of the Cell Proliferation Expansion in the Columnar Mucosa of the Distal Esophagus in Patients with GERD: Immunohistochemical Analysis of Ki67 (MIB1) Antigen in Columnar Mucosa with and Without Intestinal Metaplasia Marcelo Binato, Renato B. Fagundes, Luise Meurer, Maria Isabel A. Edelweiss, Richard R. Gurski* The Pathogenesis of Barrett's Esophagus: The Combination of Acid and Bile Is Synergistic in the Induction of CDX2 and EGFR Activation in Esophageal Cells Nelly E. Avissar*, Liana Toia, Yingchuan Hu, Alexi Matousek, Daniel Raymond, Carolyn E. Jones, Thomas J. Watson, Jeffrey H. Peters Bile Reflux Induces Higher COX-2 Expression Than Mixed Acid and Bile Reflux in a Rat Model of Esophagitis Reginald V. N. Lord*, Stefan Oberg, Jeffrey H. Peters, Steven R. DeMeester, Jeffrey A. Hagen, Tom R. DeMeester

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION I: BASIC / HEPATIC M1851

M1852

P-226

Cellular Liver Regeneration After Extended Hepatic Resection in Pigs Ruth Ladurner*, Martin Schenk, Frank Traub, Alfred Koenigsrainer, Jorg Glatzle Basics of Mouse Liver Anatomy from a Microsurgical Point of View Peter Studer*, Daniel Sidler, Beat Gloor, Andre E. Dutly, Daniel Candinas, Daniel Inderbitzin

Sails Pavilion San Diego Convention Center

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION I: BASIC / SMALL BOWEL M1861

Practical Considerations and Survival Techniques for a Rat Model of Roux-en-Y Gastric Bypass Drew A. Rideout*, Steven S. Rakita, Yanhua Peng, William R. Gower, Michel M. Murr

M1862



Activation of Wnt Signaling Protects Intestinal Epithelial Cells from Apoptosis By Increasing Cytoplasmic Levels of RNA-Binding Protein HuR Emily C. Bellavance*, Lan Liu, Rao N. Jaladanki, Tongtong Zou, Douglas J. Turner, Jian-Ying Wang

M1863

The Immunonutrient Fish Oil Increases Blood Flow in the Ileum During Chronic Feeding in Rats Ryan T. Hurt*, Paul J. Matheson, Brian M. Derhake, El Rasheid Zakaria, Richard N. Garrison

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION I: BASIC / STOMACH M1864

Survivin Expression in Gastric Cancer: Association with Histomorphological Response to Neoadjuvant Therapy and Prognosis Daniel Vallbohmer*, Uta Drebber, Paul M. Schneider, Stephan E. Baldus, Elfriede Bollschweiler, Jan Brabender, Stefan Monig, Arnulf H. Hoelscher, Ralf Metzger

M O N D A Y MAY 19

Denotes DDW Poster of Distinction

P-227

POSTER SESSIONS—COMBINED COMBINED AASLD Poster Session 8:00 AM - 5:00 PM

M1876

The Effect of Pre-Transplant Metabolic Syndrome in HCV Patients Undergoing OLT Veronika Gagovic, Beth E. Juliar, Mazen Alsatie, Naga P. Chalasani, Jonathan A. Fridell, Marco A. Lacerda, Suthat Liangpunsakul, Richard S. Mangus, Vijay Laxmi Misra, A Joseph Tector, Rodrigo Vianna, Rakesh -. Vinayek, Raj Vuppalanchi, Paul Kwo*

Sails Pavilion San Diego Convention Center

ACUTE LIVER FAILURE, LIVER TRANSPLANTATION: EXPERIMENTAL AND CLINICAL M1866



Accuracy of Abdominal Imaging in Diagnosing Submassive Hepatic Necrosis in Acute Liver Failure Versus Cirrhosis Andrew Kim*, Doan-Trang T. Tran, Steven-Huy B. Han, Steve Raman, Peter Zimmerman, Peggy Sullivan, Charles R. Lassman, Eva Chin

M1877

Factors Predicting Relapse in Those Undergoing Orthotopic Liver Transplantation for Alcoholic Cirrhosis Kashif J. Khan, Colin Terry, Audrey Krause, Amy Bax, Mazen Alsatie, Jonathan A. Fridell, Marco A. Lacerda, Richard S. Mangus, Vijay Laxmi Misra, A Joseph Tector, Rodrigo Vianna, Rakesh -. Vinayek, Paul Kwo*

M1867

Hyperamylasemia in Acute Liver Failure: Analysis of Data from the Acute Liver Failure Study Group Gregory A. Cote*, Jeanne Gottstein, Andres T. Blei

M1878

M1868

Uninsured and Medicaid Patients Have Higher Mortality in Acute Liver Failure Ashwin N. Ananthakrishnan*, Emily L. McGinley, Kia Saeian

Risk Factors and Outcomes in Post Orthotopic Liver Transplantation Bile Duct Stones and Casts: A Case Control Study Bret J. Spier*, Patrick R. Pfau, Michael R. Lucey, Adnan Said

M1879

MELD Score Predicts 3-Month Mortality in Hepatitis C Liver Transplant Patients with Recurrent Graft Cirrhosis Virginia Clark*, Roberto J. Firpi, Consuelo Soldevila-Pico, Giuseppe Morelli, Cynthia Levy, Roniel Cabrera, Victor I. Machicao, David R. Nelson

M1880

Tacrolimus Sensitivity of Pbmcs and Its Effect On Clinical Outcome in Living Donor Liver Transplantation for Hepatocellular Carcinoma Abuduxukuer Mijiti*, Matsuno Naoto, Nagao Takeshi, Hirano Toshihiko

M1881

High Mortality After Transjugular Intrahepatic Portosystemic Shunt Placement in Liver Transplant Recipients Armin Finkenstedt*, Ivo W. Graziadei, Walter Mark, Wolfgang Vogel

M1882

Ethnic-Specific Variations in Liver Disease Etiology Among Liver Transplant Recipients Nyingi Kemmer*, Victoria C. Zacharias, Tiffany E. Kaiser, Philippe J. Zamor, Guy W. Neff

M1883

Viral Load Predicts Outcome of Hepatitis C After Liver Transplantation Ivo W. Graziadei*, Walter Mark, Wolfgang Vogel

M1884

Safety and Success of Percutaneous Liver Biopsy Between Hepatologists and Radiologists Mashal Jatoi*, Ayodele T. Osowo, Elizabeth J. Carey, David D. Douglas

M1885

Causes and Therapy of Anemia After Orthotopic Liver Transplantation (OLT) Maurizio Bonacini*, Catherine A. Carr, Nata DeVole, Andrew Cummins, Robin Bishop

M1886

Transcatheter Arterial Chemoinfusion (TACI) Is Effective As a Bridge Towards Orthotopic Liver Transplantation and Downstaging to Maintain or Achieve Milan Criteria in Patients with Unresectable Hepatocellular Carcinoma (HCC) Whitney de Luna*, Bo Yoon Ha, Aijaz Ahmed, Daniel Y. Sze, Emmet B. Keeffe, Mindie H. Nguyen

M1887

Risks and Outcome After Liver Transplantation in Patients with Ischemic-Like Cholangiopathy with Secondary Sclerosing Cholangitis Gabi I. Kirchner*, Marcus N. Scherer, Reiner Wiest, Aiman Obed, Matthias Froh, Juergen Schoelmerich, Cornelia M. Gelbmann

M1869

M O N D A Y MAY 19

A Phase I/II Study of Recombinant Human Hgf (Rh-Hgf) for the Treatment of Fulminant Hepatic Failure: A Safety Evaluation in Four Subjects Who Were Administered Repeated Doses of Rh-Hgf Masatsugu Numata*, Akio Ido, Hiroyuki Marusawa, Akihiro Moriuchi, Kazuki Ikeda, Hitoshi Setoyama, Naohisa Yamaji, Hiroshi Ida, Hirofumi Uto, Makoto Oketani, Tsutomu Chiba, Hirohito Tsubouchi

M1870

Molecular Adsorbent Recirculating System in Patients with Primary Non-Function and Other Causes of Graft Dysfunction After Liver Transplantation Lorenzo Zileri Dal Verme*, Rita Gaspari, Alfonso W. Avolio, Giuseppe Merra, Michele Santoro, Marco Castagneto, Rodolfo Proietti, Antonio Gasbarrini

M1871

Mild Hypothermia Does Not Affect Liver Regeneration After Partial Hepatectomy in Mice Juan Pablo Arab, Margarita Pizarro, Nancy Solis, Sundararajah Thevananther, Marco A. Arrese*

M1872

Abnormal Urinary Excretion of Phosphate Is Responsible for Hypophosphatemia in Acute Liver Failure Blake Gregory*, Clarita V. Odvina, Orson Moe, Joseph Zerwekh, Khashayar Sakhaee, William M. Lee

M1873

M1874

M1875

P-228

Correlation of MELD with King's College Hospital Criteria in Non Alcohol and Non Acetaminophen Induced Acute Liver Failure Khalid Mumtaz*, Om Parkash, Wasim Jafri, Saeed S. Hamid, Hasnain Shah, Shahab Abid Hepatitis B Immunoglobulin and Lamivudine Reduce Hepatitis B Virus-Related Morbidity and Mortality in Chronic Hepatitis B Patients Undergoing Liver Transplantation: Meta-Analysis Rohit Loomba*, Ayana K. Rowley, Robert Wesley, T Jake Liang, Frank Pucino, Gyorgy Csako Use of Growth Factors During Interferon-Based Therapy for Recurrent Hepatitis C Virus Infection Following Liver Transplantation Sarah Sheibani*, Anastasia Waechter, Jason Lee, Lynn Shapiro, Maximilian Lee, Aijaz Ahmed, Ahmad Kamal

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED M1888

Patient Outcomes in Liver Transplantation for Hepatocellular Carcinoma At a Major Transplant Center in the United States Michael Schafer*, Daniel F. Schafer

AASLD Poster Session 8:00 AM - 5:00 PM



Survival After Orthotopic Liver Transplantation: The Impact of Antibody Against Hepatitis B Core Antigen in the Donor Lei Yu*, Thomas Koepsell, George Ioannou

HBV: PATHOGENESIS AND TREATMENT

M1890

Is There a Justification for the Attitudes and Practices of Hepatologists and Transplant Surgeons Regarding Transplantation in Patients with Alcoholic Liver Disease? Andrew Aronsohn*, J. Richard Thistlethwaite, Donald M. Jensen, Lainie F. Ross

M1889

Sails Pavilion San Diego Convention Center

M1901

Predicting Which Inactive HBsAg (+) Carrier Will Meet Treatment Criteria During Long-Term Follow-Up Bulent Degertekin*, Jessica Tan, Stephen N. Wong, Scott Fung, Munira T. Hussain, Anna S. Lok

M1902



Partial External Biliary Diversion in Children with Progressive Familial Intrahepatic Cholestasis Huiqi Yang*, Henkjan J. Verkade, Robert J. Porte, Zacharias J. De Langen, Jan B. Hulscher

Detection of Entecavir-Resistant (ETV-R) Mutations in Nucleoside-Naïve and in Lamivudine-Refractory (Lvd-R) HBV Patients and Implications On Response to ETV Treatment Bulent Degertekin*, Munira T. Hussain, Kelly Oberhelman, Robert J. Fontana, Jorge A. Marrero, Hari S. Conjeevaram, Hellan Kang, Anna S. Lok

M1903

M1892

Endoscopic Retrograde Cholangiopancreatography in the Pre-Operative Evaluation of Living Related Liver Transplant Donors Christopher Kleeman*, Burckhardt Ringe, David Anjelly, Asyia S. Ahmad, James C. Reynolds, Ricardo Morgenstern

Hepatitis B Virus DNA in Liver Tissue and Risk for Hepatocarcinogenesis in Patients with Hepatitis C VirusRelated Chronic Liver Disease: A Prospective Study Mikako Obika*, Toshiyuki Shinji, Shin-ichi Fujioka, Hidenori Shiraha, Ryo Terada, Norio Koide

M1904

Prevalence of HBeAg and HBV Genotypes in Romania Florin A. Caruntu

M1905

Clinical Significance of Concurrent Hepatitis B Surface Antigen and Antibody Positivity in Chronic Hepatitis B Patients Based On Mutations of Pres Gene Hyoung Su Kim*, Ji Sun Jang, Woon Geon Shin, Kyung Ho Kim, Jin Heon Lee, Hak Yang Kim, Myoung Kuk Jang

M1906

Analysis of Factors Affecting HBeAg Early Seroconversion to anti-HBe in Acute Exacerbation of HBeAg Positive Chronic Hepatitis B with Genotype C; a Prospective Study Hyoung Su Kim*, Ji Won Park, Ji Sun Jang, Woon Geon Shin, Kyung Ho Kim, Jin Heon Lee, Hak Yang Kim, Myoung Kuk Jang

M1891

M1893

Are Post-Orthotopic Liver Transplant Patients At Higher Risk for Post-ERCP-Pancreatitis? Murad A. Abu Rajab*, S.Ian Gan

M1894



Development of An Artificial Bile Duct Made of Bioabsorbable Polymer to Be Used for Treatment of Biliary Stenosis Masayasu Aikawa*, Mitsuo Miyazawa, Katsuya Okada, Yasuko Toshimitsu, Yoshihide Otani, Isamu Koyama

M1895

Proteomic Analysis of Hepatic Ischemia/Reperfusion Injury and Ischemic Preconditioning in Mice Revealed the Protective Role of Atp5b Xuequn Zhang, Chengfu Xu, Chaohui Yu, Guohua Lu, Shaohua Chen, Liming Xu, Wei Ding, Qiaojuan Shi, Youming Li*

M1907

Deletion of CD39 On Natural Killer Cells Attenuates Warm Hepatic Ischemia/Reperfusion Injury Guido Beldi*, Yara Banz, Alexander Kroemer, Annette Pexa, Yan Wu, Keichi Enjyoji, Daniel Candinas, Xian C. Li, Simon C. Robson

Efficacy of Entecavir in Nucleoside-Naïve Patients with Mildly Elevated ALT Stuart C. Gordon*, Steven-Huy B. Han, Ting-Tsung Chang, Ching Lung Lai, Kwang-Hyub Han, You Chen Chao, CheeKiat Tan, William Sievert, Tawesak Tanwandee, B. L. Neo

M1908

Tenofovir Disoproxil Fumarate (TDF) for the Treatment of HBeAg-Negative Chronic Hepatitis B: Week 72 TDF Data and Week 24 Adefovir Dipivoxil Switch Data (Study 102) Patrick Marcellin*, Ira M. Jacobson, Naoky Tsai, Natalie Bzowej, François Habersetzer, Hakan Senturk, Christopher D. Moyes, Gerlinde Teuber, Jeff Sorbel, Jane Anderson, Elsa Mondou, Joe Quinn, Franck Rousseau



M1896



M1897



Lymph Nodes As a New Site for Liver Regeneration Toshitaka Hoppo*, Rohan Manohar, Donna B. Stolz, Eric Lagasse

M1898



The Role of Vascular Endothelial Growth Factor and Its Receptor in Liver Regeneration After Partial Hepatectomy Eline Vanheule*, Ye-Dong Fan, Jacques Van Huysse, Daniel Meester, Marleen Praet, Bernard de Hemptinne, Isabelle Colle

M1899

The Role of Placental Growth Factor and Its Receptor in Liver Regeneration After Partial Hepatectomy Eline Vanheule*, Ye-Dong Fan, Jacques Van Huysse, Daniel Meester, Marleen Praet, Bernard de Hemptinne, Isabelle Colle

M1900

Endoscopic Management of Biliary Complications After Living Donor Liver Transplantation Hemant A. Shah*, Leslie Lilly, Krishna C. Gurram, Ramasamy Saravanan, Paul P. Kortan, Gary R. May, Samir C. Grover



M1909

Will Interferon and Anti-Viral Therapy Reduce Risk of HBV-Related Liver Cancer? Joseph J. Sung*, Kelvin K. Tsoi, Kevin C. Li, Vincent W. Wong, Henry Lik-Yuen Chan

M1910

Tenofovir Disoproxil Fumarate (TDF) Is Highly Active for Treatment of Chronic Hepatitis B in Subjects with Cirrhosis Chia Wang*, Maria Buti, Stephanos J. Hadziyannis, Philipe Mathurin, Morris Sherman, Simone I. Strasser, Joerg Petersen, Myron J. Tong, Jeff Sorbel, Elsa Mondou, Jane Anderson, Franck Rousseau

M1911

Cost-Effectiveness of Screening for Hepatitis B Infection Among Asian-Americans Undergoing Chemotherapy Walter G. Park*, Maureen E. Morgan, Ahmad Kamal

Denotes DDW Poster of Distinction

P-229

M O N D A Y MAY 19

POSTER SESSIONS—COMBINED M1912

The Antiviral Response to Tenofovir Disoproxil Fumarate (TDF) Is Comparable in Lamivudine (LAM)Naïve and LAM-Experienced Subjects Treated for Chronic Hepatitis B (CHB) Nezam Afdhal*, Michael P. Manns, Lennox J. Jeffers, Tuan Nguyen, Thomas Berg, Georgios N. Dalekos, Christian Trepo, Stuart K. Roberts, Martin Prieto, Jeff Sorbel, Jane Anderson, Elsa Mondou, Franck Rousseau

M1913

Lack of Influence of Baseline Genotype On Antiviral Response in Subjects with Chronic Hepatitis B Infection Receiving Tenofovir Df 300 Mg Qd for 1 Year Zobair M. Younossi*, Yves Benhamou, Ed J. Gane, Stefan Zeuzem, Jenny Heathcote, Patrick Marcellin, Jeff Sorbel, Katyna Borroto-Esoda, Franck Rousseau, Andrea SnowLampart

M1914

M1915

M1916

M1917

M1918

M1919

M O N D A Y

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Participants will be able to: • Update in Barrett's diagnosis and management.

Three-Years of Continuous Entecavir Treatment in Chinese Patients Who Had Previously Failed Lamivudine: Results from Studies ETV-056 and -050 Guang-Bi Yao*, Dao-Zhen Xu, Hong Ren, Xia-Qiu Zhou, JiDong Jia, Yu-Ming Wang, Cheng-Wei Chen, Jessica Liu, Dong Xu, Cyril Llamoso Occult Hepatitis B in Surface Antigen Negative Liver Transplantation Living Donors Yen-Hsuan Ni*, Ming-Chih Ho, Daw-Jen Tsuei, Mei-Hwei Chang, Po-Huang Lee Does Free HBV Vaccination Lead to Higher Coverage Among Asian American Adults? Results of a Community Outreach Program Naoky Tsai*, Peter Holck, Aldrich Ricalde The Combination of Lamivudine and Adefovir Prevents Both Lamivudine and Adefovir Resistance in Patients with Chronic Hepatitis B Christophe Hezode, Valerie Dhalluin-Venier*, Stephane Chevaliez, Francoise Roudot-Thoraval, Ariane Mallat, JeanMichel Pawlotsky

Absence of Effect of Telbivudine On Cardiac Repolarization (Qt/Qtc Interval Duration) in Healthy Subjects: Evidence of a Broad Safety Margin Xiao-Jian Zhou*, Stuart I. Harris, Dodie Frank, Barbara A. Fielman Constance, June Ke, Gillian Zeldin, Douglas L. Mayers

P-230

Correlation Between HBV DNA Level and Progression to Cirrhosis in Patients with Chronic Hepatitis B Jiyao Wang*, Lili Liu

Hepatitis B Virus Variation Discovery in Patients Under Long-Term Lamivudine Treatment Using Base-Specific RNA Cleavage and Maldi-Tof Mass Spectrometry Ju Luan*, Henry LY Chan, Joseph JY Sung, Chunming Ding

M1921

M1923

M1925

Sponsored by: Esophageal, Gastric & Duodenal Disorders

The Efficacy of Combination Therapy with Adefovir and Lamivudine in Patients with Chronic Hepatitis B Jose Giron*, Nikolaos T. Pyrsopoulos

M1922

Three-Years of Continuous Treatment with Entecavir Results in High Proportions of Chinese NucleosideNaive Patients with Undetectable HBV DNA: Results from Studies ETV-023 and -050 Guang-Bi Yao*, Dao-Zhen Xu, Hong Ren, Xia-Qiu Zhou, JiDong Jia, Yu-Ming Wang, Cheng-Wei Chen, Jessica Liu, Dong Xu, Cyril Llamoso

HBV Prevention Strategies Using anti-HBc Positive Liver Donors Robert P. Perrillo

M1920

MAY 19

M1924

Virological Response During Treatment of Chronic Hepatitis B with Pegylated Interferon Alfa-2a in Children Malgorzata Pawlowska*, Waldemar Halota Tenofovir Disoproxil Fumarate (TDF) Versus Emtricitabine Plus TDF for Treatment of Chronic Hepatitis B (CHB) in Subjects with Persistent Viral Replication Receiving Adefovir Dipivoxil (ADV) Thomas Berg*, Bernd Moeller, Huy N. Trinh, Sing Chan, Patrick Marcellin, Emilio Suarez, Andrea Snow-Lampart, David Frederick, Katyna Borroto-Esoda, David W. Oldach, Jeff Sorbel, Franck Rousseau

BARRETT'S DIAGNOSIS AND MANAGEMENT

M1926



Risk of Malignant Progression in Patients with Barrett's Esophagus: A Long-Term Nation-Wide Study P. J. de Jonge*, M. van Blankenstein, Caspar W. Looman, M. K. Casparie, Gerrit A. Meijer, E. J. Kuipers

M1927



Does Microscopic Barrett's Esophagus Progress to Barrett's Esophagus? Data from the Population-Based Kalixanda Study Jukka Ronkainen*, Pertti Aro, Tom Storskrubb, Nicholas J. Talley, Michael Vieth, Tore Lind, Lars Agreus

M1928

P53 Immunostaining Predicts Malignant Progression in Barrett's Metaplasia Keith Brown, Mamoun Younes*, Atilla Ertan, Ray Verm, Frank V. Meriano, John C. McKechnie, Ronald C. Colman, Juan Lechago

M1929

Obstructive Sleep Apnea and Barrett's Esophagus Linda C. Cummings*, Ninad H. Shah, Santo Maimone, Wajeeh Salah, Vijay S. Khiani, Beth Bednarchik, Sanjay R. Patel, Susan Redline, Amitabh Chak

M1930

Lgr5 Is a Novel and Promising Marker for Dysplastic Progression and Adenocarcinoma of the Esophagus Laren Becker*, Qin Huang, Hiroshi Mashimo

M1931

The Utility of Cytologic Diagnosis of Dysplasia in Patients with Barrett's Metaplasia Mamoun Younes*, Melissa P. Upton, Nirag Jhala, Gregory Y. Lauwers, Atilla Ertan, Ray Verm, Frank V. Meriano, John C. McKechnie, Ronald C. Colman, Juan Lechago

M1932

A Comparison of Two Fluorescence in situ Hybridization Probe Sets for the Detection of High-Grade Dysplasia and Adenocarcinoma in Endoscopic Brushing Specimens from Patients with Barrett's Esophagus Shannon M. Brankley*, Emily Barr Fritcher, Michael B. Campion, Lori S. Lutzke, Kenneth K. Wang, Kevin C. Halling

M1933

Biopsy Yield of Dysplastic Barrett's Esophagus Based On Location Within the Barrett's Segment Evan S. Dellon*, Ryan D. Madanick, Steven A. Edmundowicz, Robert H. Hawes, Blair A. Jobe, Nicholas J. Shaheen

M1934

Biomarker Status Post Ablation Can Predict Recurrent Dysplasia in Barrett's Esophagus: A Prospective Study Ganapathy A. Prasad*, Kevin C. Halling, Shannon M. Brankley, Navtej Buttar, Louis-Michel Wong Kee Song, Alan R. Zinsmeister, Lori S. Lutzke, Kelly T. Dunagan, Lynn S. Borkenhagen, Kenneth K. Wang

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED M1935

Stepwise Circumferential and Focal Radiofrequency Ablation of Barrett's Esophagus Preserves Esophageal Diameter, Compliance and Motility Hanneke Beaumont*, Joep J. Gondrie, Barry P. McMahon, Hans Gregersen, Wilda Rosmolen, Jacques J. Bergman, Guy E. Boeckxstaens

AGA Institute Poster Session 8:00 AM - 5:00 PM

Identification and Validation of Biomarkers for Use in Barrett's Oesophagus Screening Pierre Lao-Sirieix*, Alex Boussioutas, Lakshmi Harihar, Rebecca Fitzgerald

BARRETT'S ESOPHAGUS: PATHOGENESIS

M1937

The Prague C & M Criteria for Grading Barrett's Esophagus: A Real-Time Clinical Evaluation of Observer Agreement James D. Shutt*, David C. Chan, Christopher P. Boger, Praful Patel

M1947



Combinational Chemoprevention Using Low Dose Aspirin and Urso in Barrett's Mucosa Sumera Ilyas*, Cathrine J. DeMars, Lori S. Lutzke, Kenneth K. Wang, Navtej Buttar

M1948

M1938

The Significance of An Indefinite for Dysplasia Diagnosis in Patients with Barrett's Metaplasia Mamoun Younes*, Gregory Y. Lauwers, Atilla Ertan, Ray Verm, Frank V. Meriano, John C. McKechnie, Ronald C. Colman, Juan Lechago



The Down-Regulation of a HMG Box Gene SOX2 By Exposure to Acid and Bile Induces the Progression of Barrett's Esophagus Sho Asonuma*, Akira Imatani, Yasuhiko Abe, Tomoyuki Koike, Naoki Asano, Shuichi Ohara, Tooru Shimosegawa

M1949

M1939

New Onset of GERD Phenotypes During Follow Up of First-Degree Relatives of Patients with Barrett's Esophagus - Preliminary Report Debra M. Geno, Adil A. Abdalla, Judith McElhiney, Matthew R. Lohse, Mary Fredericksen, Ross A. Dierkhising, Amindra S. Arora, Rayna M. Grothe, Tushar S. Dabade, MhdMaan Alkhatib, Adam L. Ware, Mindy J. Kern, Joseph a. Murray, Jeffrey A. Alexander, Jessica L. Kimber, Ijeoma A. Azodo, Suwebatu T. Odunsi, Ganapathy A. Prasad, Dawn L. Francis, Yvonne Romero*



Molecular Pathogenesis of Early Development and Progression of Barrett's Esophagus Sydney D. Finkelstein*, William D. Lyday

M1950

The Association of Circulating Adiponectin Multimers with Barrett's Esophagus. Joel H. Rubenstein*, John Y. Kao, Ryan D. Madanick, Min Zhang, Meizhi Wang, Melissa Spacek, Jena Donovan, Stephanie D. Bright, Nicholas J. Shaheen

M1951

A Prospective Study of Body Mass Index and Barrett's Esophagus Brian C. Jacobson*, Charles S. Fuchs

M1952

Effects of Helicobacter pylori Infection On Genetic Instability, Aberrant CpG Island Methylation Status and Cellular Phenotype in Intestinal Metaplasia of Barrett's Esophagus in Japanese Population: A Prospective Follow-Up Study After Eradication Kentaro Moriichi*, Jiro Watari, Kiron M. Das, Hiroki Tanabe, Ryu Sato, Amen H. Zaky, Nobuhiro Ueno, Youkou Konno, Chisato Ishikawa, Yuhei Inaba, Takahiro Ito, Kotaro Okamoto, Atsuo Maemoto, Mikihiro Fujiya, Toshifumi Ashida, Yutaka Kohgo

M1953

GLI-1 Expression Suggests That Sonic Hedgehog Signaling May Be Involved in the Pathogenesis of Barrett's Esophagus Laura J. Tafe*, David J. Robbins, Dennis L. Fei, Amitabh Srivastava

M1936

M1940

Duodeno-Gastro-Esophageal Reflux (DGER) and Barrett's Esophagus: Evaluation with Esophageal Multichannel Intraluminal Impedance (MII) and Bilitec 2000 Regarding Mitogen Activated Protein Kinases (MAPKS) Activity Profile Adam Chwiesko*, Andrzej Baniukiewicz, Justyna WasielicaBerger, Andrzej Dabrowski

M1941

Factors Associated with Detection of Dysplasia in Barrett's Esophagus Surveillance: Analysis of a National Community-Based Gastrointestinal Pathology Database Robert C. Kapel*, Julian A. Abrams, Guy M. Lindberg, Mohammad H. Saboorian, Charles J. Lightdale

M1942

Comparison of Catheter-Based Radiofrequency Ablation and Photodynamic Therapy for Barrett's Esophagus Joseph M. Bumgarner*, Masoud Panjehpour, Millie Long, Evan S. Dellon, Bergein F. Overholt, Nicholas J. Shaheen

M1943

Specific Increase of Lectin UEA-I Binding Proteins in the Squamous Epithelium of Patients with Barretts Esophagus Helmut Neumann*, Thomas Wex, Klaus Mönkemüller, Michael Vieth, Lucia C. Fry, Peter Malfertheiner

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

Participants will be able to: • Update on progress in Barrett's Esophagus pathogenesis.

M1954

A Telomerase-Immortalized, Non-Neoplastic, Human Barrett's Cell Line As Model of Ion Transport and Barrier Function of Native Barrett's Specialized Columnar Epithelium Biljana Jovov*, Geraldine S. Orlando, Karen L. Brown, Roy C. Orlando

M1944

The Molecular Pathology of Radiofrequency Mucosal Ablation of Barrett's Esophagus Sydney D. Finkelstein*, William D. Lyday

M1955

M1945

Diagnosis of Gastro-Esophageal Reflux (GER) in Barrett Esophagus (BE). What Is the “Gold Standard” Study? Luis Durand*, Fernando J. Barreyro, Marina Orsi, Edith Telerman, Enrique H. Covian

Exposure to Both Radiation and Chemotherapy Increases the Risk of Barrett's and Multilayered Epithelium Helen M. Shields*, Abram Recht, Helen H. Wang

M1956

Bimodal Effects of Dietary Macronutrient Manipulation On Carcinogenesis in Barrett's Mucosa Cathrine J. DeMars*, Vidu B. Mokkala, Sumera Ilyas, Raul A. Urrutia, Kenneth K. Wang, Lori S. Lutzke, Ravinder J. Singh, Navtej Buttar

M1957

Expression of Bile Acid Transporting Proteins in Barrett's Esophagus and Esophageal Adenocarcinoma Katerina Dvorak*, Lois Ramsey, George S. Watts, Hana Holubec, Claire Payne, Harris Bernstein, Carol Bernstein, Richard E. Sampliner, Harinder S. Garewal

M1946

Progression of Barrett's Metaplasia to Adenocarcinoma Is Associated with the Expression of Unphosphorylated Retinoblastoma Gene Product (pRB) Alexander Braun*, Thomas Kratt, Dietmar Stüker, Alfred Königsrainer

Denotes DDW Poster of Distinction

P-231

M O N D A Y MAY 19

POSTER SESSIONS—COMBINED M1958

M1959

M1960

M1961

M1962

M1963

M O N D A Y MAY 19

Frequency of 20q13 Gain As Detected By Fluorescence in Situ Hybridization (FISH) in Cytologic Brushing Specimens from Patients with a History of Barrett's Esophagus Emily Barr Fritcher*, Shannon M. Brankley, Michael B. Campion, Lori S. Lutzke, Kenneth K. Wang, Kevin C. Halling

M1970

Differential Effects of TNF-α On Oesophageal Cell Lines Along the Metaplasia-Dysplasia-Adenocarcinoma Sequence Anna M. Nicholson, Ramon D. Arscott, Anita Milicic, Janusz A. Jankowski*

M1971

Barrett's Esophagus and the GERD Mucosa Are Characterized By a Predominantly Humoral Inflammatory Response and the Development of An Adaptive Secretory IgA System Adrian Schmassmann*, Diana Schmassmann-Suhijar

M1972

Role of Cell Senescence in Ablative Therapy of Barrett's Esophagus Kenneth K. Wang*, Rami J. Badreddine, Ganapathy A. Prasad, Navtej Buttar, Louis-Michel Wong Kee Song, Marlys Anderson, Lori S. Lutzke, Kelly T. Dunagan, Lynn S. Borkenhagen

Distinct Dendritic Cell Populations in Reflux Disease and Barrett's Esophagus; Implications for Understanding the Immune Response Rebecca C. Kiekens, Peter D. Siersema*

M1973

Autoregulation of Cdx1 and Cdx2 in Development of Barrett's Epithelium Hideaki Kazumori*, Mika Yuki, Yoshinori Komazawa, Toshihiro Shizuku, Yoshikazu Kinoshita

A Long Term in-Vitro Model of Squamous Adult Oesophagus Applicable for Investigating Genetic and Environmental Factors Responsible for Barrett's Metaplasia Benjamin J. Colleypriest*, John Farrant, David Tosh

M1974

Cdx-2 and Sonic Hedgehog Gene Expression in the Proximal, Middle, and Distal Regions of Columnar Mucosa in Long Segment Barrett's Esophagus Daniel S. Oh*, Steven R. DeMeester, Ryutaro Mori, Hidekazu Kuramochi, Koji Tanaka, Jeffrey A. Hagen, Peter V. Danenberg, Kathleen D. Danenberg, Parakrama Chandrasoma, Tom R. DeMeester

M1975

Dietary Risk Factors for Barrett's Esophagus Lawrence A. Miller*, Lacie Brenner, Jason Taylor, Jennifer S. Kimble, Kayode O. Olowe, Beth Bednarchik, Li Li, Amitabh Chak

M1976

GERD, Barrett's Esophagus and Helicobacter pylori Infection Xiangwen Meng*, Marc A. Scheer, Tat-Kin Tsang

M1977

Association of Cyclooxigenase-2 (COX-2) Activity and Acidic and Biliary Reflux Parameters in Patients with Barrett Metaplasia András Rosztóczy, Ferenc Izbéki, Richárd Róka, László Tiszlavicz, István Németh, Wittmann Tibor*

M1978

Irregular Z-Line in Patients with Heartburn or Dyspepsia - Endoscopic and Histological Study Ram Dickman*, Zohar Levi, Alex Vilkin, Ibrahim Zvidi, Yaron Niv

Epidemiological Characteristics of Barrett's Esophagus in Spain Xavier Calvet*, Luis Bujanda, Marta Ponce, Marta Gallach, Patricia Salvador, Enrique Ojembarrena, Carmen Muñoz, Cristina Sarasqueta, Angel Cosme, Enrique Rey, Julio Ponce

Development of Multilayerd Epithelium (MLE) After Photodynamic Therapy: Is MLE a Precursor to Barrett's Esophagus? Fumihiro Ogawa, Amitabh Srivastava, Norman S. Nishioka, William P. Puricelli, Gregory Y. Lauwers, Mari MinoKenudson* Influence of Acid Reflux On Stromal Activation in Barrett's Esophagus Ganapathy A. Prasad*, Navtej Buttar, Tsung-Teh Wu, Lori S. Lutzke, Kelly T. Dunagan, Lynn S. Borkenhagen, Kenneth K. Wang

M1964

Superficial Ki67 Expression May More Accurately Measure Proliferation in Barrett's Associated Intestinal Metaplasia and High-Grade Dysplasia Ajay Bansal*, Sharad C. Mathur, Sachin B. Wani, Krishna Pondugula, Amit Rastogi, Prateek Sharma

M1965

Phosphatidylinositol-Specific Phospholipase C (PI-PLC) Mediates Bile Acid-Induced NADPH Oxidase NOX5-S Expression in Barrett's Esophageal Adenocarcinoma Cells Jie Hong, Jose Behar, Jack R. Wands, John David Lambeth, Weibiao Cao*

M1966

NADPH Oxidase NOX5-S Mediates Cyclin D1 Expression in Barrett's Esophageal Adenocarcinoma Cells Jin Si, Jie Hong, Jose Behar, Jack R. Wands, Rhonda F. Souza, Stuart J. Spechler, John David Lambeth, Weibiao Cao*

M1967

Differential Expression of Tight Junction Proteins in Barrett's Metaplasia, Dysplasia and (Esophageal) Adenocarcinoma Xiaoxin L. Chen*, Yan Ma, Rong Qin, Ryan D. Madanick, Roy C. Orlando, Nicholas J. Shaheen

M1968

Eotaxin-3 Expression and Increased Eosinophil Number in Barrett's Esophagus Compared to Reflux Esophagitis Wouter L. Hazen*, Rebecca C. Kiekens, Peter D. Siersema

M1969

Expression of Hypoxia Inducible Factor 1α (HIF-1α) in the Progression to Oesophageal Adenocarcinoma: A Key Target for Therapy Naoki Teratani, Anna M. Nicholson, Paul A. Atherfold, Anita Milicic, Janusz A. Jankowski*

P-232

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: BIOMARKERS AND GI CANCERS Participants will be able to: • Learn more about biomarkers and GI cancers. M1979

Hypermethylation of the AKAP12 Promoter in Human Esophageal Cancer Zhe Jin*, Yulan Cheng, James P. Hamilton, Yuriko Mori, Alexandru Olaru, Tetsuo Ito, Kwisa Kang, Bogdan C. Paun, Stefan David, Jian Yang, Rachana Agarwal, John M. Abraham, Stephen J. Meltzer

M1980

Loss of Transgelin in Human Colorectal Cancer and Its Up-Regulation Inhibits Colon Carcinogenesis Via Inhibiting COX-2 Expression Marie Yeo*, Hee Jin Park, Dong-Kyu Kim, Young Mi Na, Sung Won Cho, Kwang Jae Lee

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED M1981

Synergistic Effect of Microsomal Prostaglandin E Synthase (MPGES)-1, MPGES-2, and COX-2 Coexpression On Colorectal Cancer Patient Prognosis Atsushi Tatsuguchi*, Tsuguhiko Seo, Seiichi Shinji, Masaoki Yonezawa, Ken Wada, Keigo Mitsui, Shu Tanaka, Shunji Fujimori, Katya Gudis, Takashi Tajiri, Choitsu Sakamoto

M1982



Identification of Differentially Expressed Alternative mRNA Isoforms Associated with Chemotherapy Resistance in Colon Cancer Cell Lines Malachi Griffith*, Michelle J. Tang, Susanna Chan, Jennifer K. Asano, Adrian Ally, Trevor Pugh, Isabella T. Tai, Marco A. Marra

M1983

Influences of Renin-Angiotensin System-Related Gene Polymorphisms On Gastric Cancer Risks in Japan Mitsushige Sugimoto*, Takahisa Furuta, Chise Kodaira, Masafumi Nishino, Mihoko Yamade, Mutsuhiro Ikuma, Akira Hishida

M1984

Cellular Phenotypes in Adenocarcinoma of the Esophagus Angela Sefah*, Octavia Pickett-Blakely, Koushik K. Das, Manisha Bajpai, Kelly A. Walton, Kiron M. Das

M1985

Potential Cancer Prevention Markers Can Be Identified By Comparing Gene Methylation Pattern in Normal Colon Mucosa to Those of Benign and Malignant Tumours Terje Ahlquist, Espen Thiis-Evensen*, Guro E. Lind, Gunn I. Meling, Morten H. Vatn, Geir S. Hoff, Torleiv O. Rognum, Ragnhild A. Lothe

M1986

The Tumor Marker Behavior of Proteolytic Enzymes in Colorectal Cancer László Herszényi*, Fabio Farinati, Mario Plebani, Zsolt Tulassay

M1987

The Relationship Between the Expression of CycloOxygenase-2 and β-Catenin in Colorectal Cancer Seong-Eun Kim*, Sung-Ae Jung, Yang Hee Joo, Hyun Joo Song, Ki-Nam Shim, Tae Hun Kim, Hye-Kyung Jung, Kwon Yoo, Il-Hwan Moon, Min-Sun Cho

M1988

M1989

M1990

M1991

Expression of Cell Adhesion Molecule CD44 in Gastric Adencocarcinoma and Its Correlation with Cliniclopathological Characteristics and Survival Time Mostafa Jafarzadeh, Hamid Reza Sima, Ehsan Esmaeili Shandiz, Hanieh Hosseinnezhad, Kamran Ghafarzadegan, Hamidreza Raziee*, Tahoora Abdollahi, Sepideh Ghadri, Maryam Bahrani, Omeed Moaven Performance of High Magnification Colonoscopy (HMC) in Detecting Aberrant Crypt Foci (ACF) Akshay K. Gupta*, Paul Pinsky, Christopher J. Rall, Matthew Mutch, Robert E. Schoen Over-Expression of CDC25B and LAMC2 mRNA and Protein in Esophageal Squamous Cell Carcinomas and Pre-Malignant Lesions in Subjects from a High-Risk Population in China Philip R. Taylor*, Jianzhong Shou, Mikiko Takikita, Mark Roth, Jin-Zhong Shou, Laura L. Johnson, Carol Giffen, Quan-Hong Wang, Chaoyu Wang, Yuan Wang, Hua Su, LiHui Kong, Michael Emmert-Buck, Alisa M. Goldstein, Stephen M. Hewitt Selenoprotein W Expression in Human Colonic Samples Evaluated By Optical and Virtual Microscopy Using Tissue Microarrays Jeannette Molnár*, Ferenc Sipos, Tibor Krenacs, Norbert Solymosi, Gábor Valcz, Anna M. Németh, Béla Molnár, Zsolt Tulassay

M1992

Identification of Loss of Function Retinoic Acid Receptor Responser-1, Prostaglandin D2 Receptor and Forkhead Box A1 Genes As a Potential Epithelial Tumor Marker By Whole Genome Microarray Analysis from Laser Capture Microdissected (LCM) Colon Cells Sandor Spisak*, Orsolya Galamb, Norbert Solymosi, Ferenc Sipos, Kinga Toth, Béla Molnár, Zsolt Tulassay

M1993

Downregulated Cathepsin D (CTSD) and Upregulated E2f2 Transcription Factor Are Possible Progression Markers from Early to Late Stage Colorectal Cancer Determined By Antibody and Tissue Microarrays Sandor Spisak*, Orsolya Galamb, Norbert Solymosi, Barnabás Galamb, Balazs Nemes, Ferenc Sipos, Gábor Valcz, Béla Molnár, Zsolt Tulassay

M1994

Selective Up-Regulation of Claudin-1 and Claudin-2 in Colorectal Cancer Tetsushi Kinugasa

M1995



InterSPORE/EDRN Barrett's Esophagus (Be) Study: Interim Report of a Multicenter Case-Control Study of Progressors to High-Grade Dysplasia/Adenocarcinoma vs. Nonprogressors Richard E. Sampliner*, Kenneth K. Wang, Nicholas J. Shaheen, Herbert C. Wolfsen, Jean S. Wang, Stephen J. Meltzer, Kay Washington, Jesse Gu, Yingye Zheng

M1996

Hepcidin Expression Relates to Colorectal Tumour Stage Keith Roberts*, Douglas G. Ward, Matthew J. Brookes, Mushal Naqvi, Tariq Ismail, Tariq Iqbal, Chris Tselepis

M1997

Clinicopathological Features and E-Cadherin, β-Catenin, Mucins (MUC1, MUC2, MUC5ac and MUC6), CD34 and CD44v6 Expression in Early-Onset Gastric Cancers Edaise M. Silva*, Adriane G. Pelosof, Luciane T. Kagohara, Katia C. Carvalho, Ana A. Menezes, Renata A. Coudry, Andre L. Montagnini, Fernando A. Soares

M1998

Identification of Human Gastric-Cancer Stem Cells M. Puglisi*, N. Saulnier, A. Sgambato, M. Barba, Ernesto Cristiano Lauritano, A. Boninsegna, A. Piscaglia, Marialuisa Novi, Maria Assunta Zocco, F. Barbaro, Francesca Fiore, S. Alfieri, G. Doglietto, A. Cittadini, F. Michetti, Antonio Gasbarrini

M1999

Identification of CD133-Cancer Stem Cells in Hepatic Metastasis from Colon Cancer M. Puglisi*, N. Saulnier, A. Sgambato, M. Barba, Marialuisa Novi, A. Boninsegna, Anna C. Piscaglia, Ernesto Cristiano Lauritano, Maria Assunta Zocco, E. Rinninella, Mariachiara Campanale, Francesca Fiore, F. Giuliante, G. Nuzzo, A. Cittadini, F. Michetti, Antonio Gasbarrini

M2000

Prevalence of Serrated Polyps: Is There a Difference Between Australia and Japan? Kazutomo Togashi*, David G. Hewett, Kevin Spring, Vicki Whitehall, Kentaro Kurashina, Hisanaga Horie, Yoshikazu Yasuda, Mark N. Appleyard, Jeremy Jass, Barbara A. Leggett

M2001

Differential Expression of p53 and P504s in Sessile Serrated Polyps and Traditional Serrated Adenomas As Markers of Malignant Potential Nye-Thane Ngo*, Emile Tan, Paris P. Tekkis, David Peston, Patrizia Cohen

M2002

A Prospective Study On Gastric Intestinal Metaplasia: Typing, Expression of p53, BCL-2 and PCNA, and LongTerm Follow-Up Outcome Yu Sun*, Jinyu Lu, Jiyou Li

Denotes DDW Poster of Distinction

P-233

M O N D A Y MAY 19

POSTER SESSIONS—COMBINED M2003

M2004

Overexpressed Osteopontin and Osteonectin, and Underexpressed Prostaglandin D2 Receptor and Amnionless Homolog Are Sequential Protein Markers of the Colorectal Adenoma-Dysplasia-Carcinoma Sequence Determined By Tissue Microarray Analysis Orsolya Galamb*, Ferenc Sipos, Norbert Solymosi, Tibor Krenacs, Sandor Spisak, Gábor Valcz, Tamás Zágoni, Béla Molnár, Zsolt Tulassay Recovery of RUNx3 Expression in Long-Term Follow-Up After H. pylori Eradication Shunji Tachibana*, Hideyuki Konishi, Takayuki Motoyoshi, Chohei Sakakura, Naoki Wakabayashi, Shoji Mitsufuji, Keisho Kataoka

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

M2012

Contamination of the Working Channel During Endoscopic Ultrasonography Guided Fine Needle Aspiration of Lymph Nodes in Staging of Esophageal Cancer Results in False Positive Cytology Hendrik M. van Dullemen*, Bettien van Hemel, Alexander Lamprou, Agnes Ten Hoor-van 't Klooster, Rinse Weersma

M2013

Suppressor of Cytokine Signaling-2 Activity Is Diminished in Barrett's Esophagus Related Neoplasia Min Chen*, Christien J. van der Woude, Herman van Dekken, Bing Xia, Johannes G. Kusters, Ernst J. Kuipers, Monique M. Gerrits

M2014

Members of the Glutathione Pathways Are Frequent Inactivated By Promoter Hypermethylation in Barrett's Adenocarcinoma DunFa Peng*, Mohammad Razvi, Wael M. El-Rifai

M2015

Increasing Evidence for Haem Metabolism in Oesophageal Adenocarcinoma Keith Roberts*, Matthew J. Brookes, Robert Spychal, Tariq Iqbal, Chris Tselepis

M2016

Potential Therapeutic Role of Alginates in the Management of Oesophageal Adenocarcinoma Keith Roberts*, Robert Spychal, Matthew J. Brookes, Vicki Strugala, Peter W. Dettmar, Lesley M. Johnstone, Ian G. Jolliffe, Chris Tselepis

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: ESOPHAGEAL NEOPLASM: BIOLOGY, DIAGNOSIS AND THERAPY Participants will be able to: • Become familiar with esophageal neoplasm: Biology, diagnosis and therapy. M2005

M O N D A Y MAY 19

Down-Regulation of PTTG1 By siRNA Suppresses Tumorigenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma In Vivo Tetsuo Ito*, Fumiaki Sato, Kwisa Kang, Stefan David, Yulan Cheng, Yuriko Mori, Rachana Agarwal, Bogdan C. Paun, Zhe Jin, Alexandru Olaru, James P. Hamilton, Florin M. Selaru, Jian Yang, Yutaka Shimada, John M. Abraham, Stephen J. Meltzer

M2006



A Comparison of Endoscopic Ultrasound (EUS) to a Non-EUS Based Scoring System in Prediction of Lymph Node Metastases in Esophageal Cancer Gregory Zuccaro*, John J. Vargo, John A. Dumot, Rocio Lopez, Thomas Rice

M2007

Patients with Prostate Cancer Are Less Likely to Develop Oesophageal Cancer - Analysis of the SEER 9 Registries Database Sheldon C. Cooper*, Stacey H. Croft, Rosie Day, Peter Nightingale, Catherine S. Thomson, Nigel Trudgill

M2008

Risk Factors for the Development of Oesophageal Adenocarcinoma: A United Kingdom Primary Care CaseControl Study Sheldon C. Cooper*, Phil J. Graham, Peter Nightingale, Nigel Trudgill

M2009

Audit of Palliation of Oesophageal Cancer in An Upper GI Cancer Centre in the UK Purushothaman Premchand, Noor Jawad*

M2010

Notch Signaling Regulates Esophageal Epithelial Homeostasis and Tumor Progression Yizeng Yang, Douglas B. Stairs, Carmen Z. Michaylira, James J. Lee, Jiri Kalabis, Katharine D. Grugan, Claudia D. Andl, Daniela Budo, Warren S. Pear, Jonathan P. Katz, Anil K. Rustgi, Hiroshi Nakagawa*

M2011

P-234

Preservation of Gastric Acid Secretion Is Important for the Development of Barrett's Esophageal Cancer in Japanese People, Irrespective of the H. pylori Infection Status Toru Horii*, Tomoyuki Koike, Shuichi Ohara, Yasuhiko Abe, Ryosuke Kikuchi, Hatsushi Yamagishi, Kiyotaka Asanuma, Katsunori Iijima, Akira Imatani, Tooru Shimosegawa

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: PANCREATIC CANCER: BIOLOGY, DIAGNOSIS AND THERAPY Participants will be able to: • Evaluate recent research in biology, diagnosis and therapy of pancreatic cancer. M2017



First Line Treatment of Inoperable Pancreatic Adenocarcinoma with Lipid Complexed Paclitaxel Nanoparticles (EndoTAG-1) Plus Gemcitabine Compared with Gemcitabine Monotherapy: A Prospective Randomised Controlled Phase II Study Johannes M. Löhr*, Alexander Arlt, Wolf-Otto Bechstein, György Bodoky, Karel Cwiertka, Wolfgang Fischbach, Christiane Gog, Stephan L. Haas, Dirk Jäger, Matthias Karrasch, Carmen Lilla, Manfred P. Lutz, Axel Mescheder, Dmytro Osynkyy, Akos Pap, Wolfgang E. Schmidt, Manfred V. Singer, Janos Szanto, Ulrich R. Fölsch

M2018

Multidrug Resistance Transporters in Human Pancreatic Cells and Pancreatic Carcinoma Cells. Upregulation in 5-FU-Resistant Cells Wolfgang Hagmann, Ralf Jesnowski, Ralf Faissner, Changqing Guo, Johannes M. Löhr*

M2019

Expression of COX-2 Confers Growth Advantage to Pancreatic Cancer Cells Aihua Li*, Sascha Hasan, Eliane Angst, Howard A. Reber, Oscar J. Hines, Guido Eibl

M2020

Histone Deacetylation Regulates Loss of E-Cadherin Expression and Promotes Tumorigenicity in Pancreatic Cancer Ali Aghdassi*, Matthias Sendler, Frank U. Weiss, Julia Mayerle, Helmut Friess, Markus W. Buechler, Claus-Dieter Heidecke, Markus M. Lerch

M2021

Metformin Inhibits the Synergistic Effect of Insulin On Early and Late Cellular Events Induced By G-Protein Coupled Receptor Agonists in Human Pancreatic Cancer Cells Krisztina Kisfalvi*, Enrique Rozengurt

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED M2022

Integrin α6β4 Promotes Migration, Invasion Through Tiam1 Upregulation and Subsequent Rac Activation Kathleen L. O'Connor*, Zobeida Cruz-Monserrate

M2023

Expression of Cathepsin E Reverses EMT in Pancreatic Cancer Cells In Vitro and Expression Correlates with Increased Patient Survival in Human Pancreatic Adenocarcinoma Tobias Grote*, Baoan Ji, Vijaya Ramachandran, Thiruvengadam Arumugam, Huamin Wang, Craig D. Logsdon

M2024

Surgical Resection for Pancreatic Cancer: An Estimation of the Number Needed to Treat Sarah A. Rodriguez*, Douglas O. Faigel

M2025

Inhibiting Pancreatic Cancer Growth and Sensitizing the Tumor to Radiotherapy Through Downregulation of SP Proteins Shilpa Oberoi, Rajesambhaji Borade*, Neal McCollum, Santhi D. Konduri, Jimmie F. Colon, Cheryl H. Baker, Maen Abdelrahim

M2026

New Model for Testing Safety of Oncolytic FiberModified Conditionally Replicative Adenovirus Designed for Pancreatic Cancer Julia Davydova, Eric J. Brown, Selwyn M. Vickers, Masato Yamamoto*

M2027

M2028

M2029

M2030

Inoperable Pancreatic Cancer Patients Receiving Contemporary Chemotherapeutic Regimens Who Have Prolonged Survival Exhibit An Increased Risk of Metal Stent Occlusion and Cholangitis James L. Buxbaum*, Karen C. Bagatelos, Elmer Y. Chang, Henry K. Niho, James W. Ostroff Low Dose Gemcitabine Improves the Prognosis of Elderly Patients with Unresectable Advanced Pancreatic Cancer Kazuyuki Matsumoto*, Tatsuya Toyokawa, Yasuhiro Miyake, Hisae Yasumara, Masahiro Takahara, Eisuke Kaji, Morihito Nakatsu, Masaharu Ando, Mamoru Hirohata Expression of MRP2 (Multidrug Resistance-Associated Protein2) Regulates the Drug Resistance of Human Pancreatic Cancer Bunjiro Noma*, Tamito Sasaki, Yoshifumi Fujimoto, Kenichi Kuwahara, Masahiro Serikawa, Kenso Kobayashi, Hiroshi Ituki, Kazuaki Chayama



Geographic and Patient-Level Variations in Utilization of Endoscopic Ultrasonography in Patients with Pancreatic Cancer Feng Li*, Ying Zhou, Amitabh Chak, Gregory S. Cooper, Ananya Das

M2031

Tumor-Associated Macrophages (TAMS) Are Poor Prognostic Indicators in Pancreatic Cancer James J. Farrell*, Miguel Garcia, Adam P. Dicker, Chandan Guha, Hany Elsaleh

M2032

Efficacy of Endoscopic Ultrasound (EUS) Guided Celiac Plexus Neurolysis (CPN) for Managing Abdominal Pain Associated with Pancreas Cancer: A Meta-Analysis Gurpreet Singh, Marina S. Kaufman, Jonathan A. Erber*, Sourish Das, Carlos Micames, Bogdan Cristescu, Frank G. Gress

M2033

Blockade of TNF Alpha Reduces Pancreatic Tumor Growth and Metastasis in a Xenotransplantation Model Jan H. Egberts*, Bodo Schniewind, Clemens Schafmayer, Andreas Noack, Juergen Tepel, Fred Faendrich, Holger Kalthoff, Anja Trauzold

M2034

Statins Suppress Angiogenic Mediators in Pancreatic Carcinogenesis: Implications for Chemoprevention Tiffany N. Graybill*, Jennifer Koetsier, Dhananjay Kunte, Ramesh K. Wali, Hemant K. Roy

M2035

Ductal Adenocarcinoma of the Pancreas: Expression of Growth Factor Receptors, Oncogenes and Suppressor Genes and Its Relationship to Pathological Features, Staging and Survival Antonio Lozano-Leon, Begoña Vieites, Jose Larino-Noia, Julio Iglesias-Garcia, Evaristo Varo, Jeronimo Forteza, Enrique Dominguez-Munoz*

M2036

Early Fractalkine Receptor (CX3CR1) Switch-On in Pancreatic Ductal Adenocarcinoma Is Associated with Local Neural Invasion Luigi Laghi*, Paolo P. Bianchi, Federica Marchesi, Paola Allavena, Marco Montorsi, Alberto Mantovani, Alberto Malesci

M2037

The Effect of Sequential Combination of Hyperthermia and Gemcitabine for the Treatment of Advanced Unresectable Pancreatic Cancer Satoshi Kokura*, Takeshi Ishikawa, Takashi Ando, Tomohisa Takagi, Osamu Handa, Yuji Naito, Hirokazu Oyamada, Toshikazu Yoshikawa

M2038

Carcinoma of Ampulla of Vater: Effect of Preoperative Biliary Drainage On Outcome of Surgery Sheikh Anwar Abdullah*, Tarun Gupta, Alexander Chung, London L. Ooi, Steven Mesenas

M2039

Rosiglitazone Attenuates Gemcitabine-Induced Apoptosis Via Cell-Cycle Inhibition in Pancreatic Adenocarcinoma Gregory L. Livers*, Jill D. Coursen, Qiang Dai, Bethanie White, Matthew A. Firpo, Sean J. Mulvihill

M2040

Expression of Proteins Involved in TGF-Beta Signaling Pathway in Human Pancreatic Cancer Cell Lines Eugene A. Volpe*, Bibhutibushan Mishra, Lopa Mishra, Stephen R T. Evans

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

GENETICS Participants will be able to: • Understand the effects of genetics on inflammatory bowel disease. M2041

M2042

The First Two Crohn's Disease Susceptibility Loci with a High Degree of Epistasis: PTGER4-ExpressionModulating Polymorphisms in the 5p13.1 Region Enhance ATG16L1-Associated Susceptibility to Crohn's Disease Julia Seiderer*, Jürgen Glas, Julia Diegelmann, Giulia Pasciuto, Cornelia Tillack, Simone Pfennig, Darina Roeske, Matthias Jürgens, Silke Schmechel, Astrid Konrad, Martin Wetzke, Helga-Paula Török, Thomas Griga, Wolfram Klein, Jörg T. Epplen, Uwe Schiemann, Thomas Mussack, Peter Lohse, Burkhard Göke, Thomas Ochsenkühn, Matthias Folwaczny, Bertram Müller-Myhsok, Stephan Brand The Role of Pregnane X Receptor (PXR/NR1i2) Gene Variants in Inflammatory Bowel Disease Julia Seiderer*, Jürgen Glas, Julia Diegelmann, Daniel Fischer, Barbara Seitz, Cornelia Tillack, Simone Pfennig, Astrid Konrad, Martin Wetzke, Thomas Griga, Wolfram Klein, Jörg T. Epplen, Uwe Schiemann, Thomas Mussack, Peter Lohse, Burkhard Göke, Thomas Ochsenkuehn, Matthias Folwaczny, Bertram Müller-Myhsok, Stephan Brand

Denotes DDW Poster of Distinction

P-235

M O N D A Y MAY 19

POSTER SESSIONS—COMBINED M2043

M2044

M2045

M2046

M2047

M2048

M O N D A Y

M2049

MAY 19

M2050

P-236

Microarray Study of Mucosal Antimicrobial Peptides in Patients with Inflammatory Bowel Disease Before and After First Infliximab Treatment Ingrid Arijs*, Leentje Van Lommel, Kristel Van Steen, Gert De Hertogh, Roel Quintens, Katleen Lemaire, Marie Joossens, Frans C. Schuit, Karel Geboes, Gert A. Van Assche, Severine Vermeire, Paul J. Rutgeerts Genetic Variations in GLI-1 and MDR-1 Do Not Predict Disease Progression in Patients with Ulcerative Colitis Marc Ferrante*, Tamara Coopmans, Isabelle Cleynen, Nathalie Vermeulen, Marie Joossens, Ingrid Arijs, Gert A. Van Assche, Paul Rutgeerts, Séverine Vermeire Reduced Metallothionein Expression in Colonic Crohn's Disease: Evidence for a New Disease-Modifying Gene Debby Laukens*, Harald Peeters, Anouk Waeytens, Sara Bogaert, Bert Vander Cruyssen, Dirk Elewaut, Filip De Keyser, Herman Mielants, Claude A. Cuvelier, Paul Van Hummelen, Jurgen Del-Favero, Erik Remaut, Martine De Vos, Pieter Rottiers Significant Differences in the Genetic Susceptibility to Crohn's Disease Between North American and European Populations Regarding Gene Variants in Phox2b, Ncf4, Fam92b, and in the Intergenic Region On Chromosome 10q21.1 Julia Diegelmann*, Jürgen Glas, Julia Seiderer, Giulia Pasciuto, Cornelia Tillack, Astrid Konrad, Silke Schmechel, Martin Wetzke, Helga-Paula Török, Simone Pfennig, Matthias Jürgens, Thomas Griga, Wolfram Klein, Jörg T. Epplen, Uwe Schiemann, Thomas Mussack, Peter Lohse, Burkhard Göke, Thomas Ochsenkühn, Matthias Folwaczny, Bertram Müller-Myhsok, Stephan Brand The CARD15 Variants Rs2066843 and Rs2076756 Are New Independent Crohn's Disease Susceptibility Genes Associated with Severe Penetrating Disease Phenotype and Frequent Need for Surgery Julia Diegelmann*, Jürgen Glas, Julia Seiderer, Giulia Pasciuto, Cornelia Tillack, Simone Pfennig, Matthias Jürgens, Astrid Konrad, Martin Wetzke, Helga-Paula Török, Thomas Griga, Wolfram Klein, Jörg T. Epplen, Uwe Schiemann, Thomas Mussack, Peter Lohse, Burkhard Göke, Thomas Ochsenkühn, Matthias Folwaczny, Bertram MüllerMyhsok, Stephan Brand Polymorphisms of IRGM Gene Predispose to Fistulizing Behaviour in Adult and Pediatric Crohn's Disease Anna Latiano, Orazio Palmieri, Maria R. Valvano, Renata D'Incà, Salvatore Cucchiara, Massimo Castro, Giuseppe Corritore, Bruno Dallapiccola, Giuseppe Vieni, Annamaria Staiano, Graziella Guariso, Salvatore Accomando, Gian L. de Angelis, Claudio Romano, Paolo Lionetti, Arrigo Barabino, Brunislava Papadatou, Vito Annese* The Thr3912THR Polymorphism of BSN Gene Predisposes to Adult and Pediatric Inflammatory Bowel Disease Orazio Palmieri, Anna Latiano, Maria R. Valvano, Renata D'Incà, Salvatore Cucchiara, Massimo Castro, Tiziana Latiano, Bruno Dallapiccola, Annamaria Staiano, Giuseppe Vieni, Graziella Guariso, Gian L. de Angelis, Paolo Lionetti, Arrigo Barabino, Giuseppe Iacono, Giuliano Lombardi, Maria Pastore, Vito Annese* Lack of Association Between Markers On 5p13.1 and 10q21.1 Loci and IBD in Italian Population Orazio Palmieri, Anna Latiano, Maria R. Valvano, Elisabetta Colombo, Renata D'Incà, Salvatore Cucchiara, Massimo Castro, Bruno Dallapiccola, Vito Annese*, Alessandro Ferraris, R. Berni Canani, Concetta Sferlazzas, Graziella Guariso, Paolo Lionetti, Arrigo Barabino, Stefano Nobile, Domenica De Venuto, A. Campanozzi

M2051

Genome-Wide Expression Profiling Reveals a Common Biomarker Gene Signature in Colitis Trinidad Montero, Xavier Llor, Angel Gil, Miquel Angel Gassull, Antonio Suarez*

M2052

IRAK-1 Single Nucleotide Polymorphism in Patients with Inflammatory Bowel Disease Stephan L. Haas*, Andreas Ruether, Manfred V. Singer, Stefan Schreiber, Ulrich Böcker

M2053

Autophagy Like Genes (ATG16l1 & IRGM), IL23R and Three Other Variants Are Associated with Pediatric Onset Crohn's Disease (CD) with Similar Risks (Odds Ratio) to Adult Onset Nicholas Peterson, Stephen L. Guthery, Lee Denson, Jessica J. Lee, Shehzad Saeed, Vincent F. Biank, Rebecca Ehlert, Gitit Tomer, Richard J. Grand, Colin D. Rudolph, Subra Kugathasan*

M2054

A Detailed Haplotype Tagging Investigation of the IL23R Gene Confirms Gene-Wide Association with Childhood Onset IBD and CD Johan Van Limbergen*, Richard K. Russell, Elaine R. Nimmo, Hazel E. Drummond, Linda Smith, Niall H. Anderson, Gail Davies, Peter M. Gillett, Paraic McGrogan, Lawrence Weaver, Michael W. Bisset, Gamal Mahdi, David C. Wilson, Jack Satsangi

M2055

Sex-Related Inheritance and Transmission Pattern in Inflammatory Bowel Disease Zuzana Zelinkova*, Pieter C. Stokkers, Klaas van der Linde, E. J. Kuipers, Christien J. van der Woude

M2056

Lack of Association Between IRGM and Crohn's Disease in Japanese Patients Demonstrates Population-Specific Differences in Inflammatory Bowel Disease Hiroki Aizawa*, Yoshitaka Kinouchi, Kenichi Negoro, Yoichi Kakuta, Eiki Nomura, Seiichi Takahashi, Tooru Shimosegawa

M2057

Variants in Genes Related to Innate (NOD2, TLR5) and Adaptive (TNFSF15/TL1A) Immune Pathways Combine to Increase the Magnitude of Anti-OmpC Expression in Jewish CD Subjects Ling Mei*, Kent D. Taylor, Dermot P. McGovern, Yoana Picornell, Xiaowen Su, Carol J. Landers, Stephan R. Targan, Jerome I. Rotter

M2058

The Distribution of the IBD5 Haplotype Among Worldwide Human Populations Stephen L. Guthery*, Chandler Gatenbee, Yuhua Zhang, Mike Bamshad, Lynn Jorde

M2059

Copy Number Variation (CNV) That Involves a Promoter Region and Homo-Oligomerization Domain of the Major Secretory Intestinal Mucin MUC2 Gene, Is Associated with Inflammatory Bowel Diseases (IBD) Chin Wen Png*, Lisa Simms, Graham L. Radford-Smith, Rajaraman D. Eri, Michael A. McGuckin, Timothy H. Florin

M2060

Haplotypes of the CNR2 Gene Are Associated with Different Sero-Reactivity to Microbial Antigens in Patients with Crohn's Disease Xiaowen Su*, Ling Mei, Carol J. Landers, Jonathan Braun, David A. Ziring, Stephan R. Targan, Kent D. Taylor, Jerome I. Rotter

M2061

LPS-Responsive Beige-Like Anchor (LRBA): A Novel Gene with a Potential Role in the Pathophysiology of Inflammatory Bowel Disease Joseph McKinley*, Patrick G. Brady, Brice Taylor, Frank Vasey, William Kerr

M2062

ATG16l1 (Autophagy-Related 16-Like 1) Crohn's Disease (CD) Associated SNP Is Not Associated with Viable Mycobacterium avium Subspecies Paratuberculosis (MAP) in the Blood of CD Patients John F. Valentine*, Jerome Elam, Saleh A. Naser

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED M2063

IBD4: The EFS Knockout Mouse Model of Ileal Inflammation Leads to a Positive Association of the Human EFS Gene with Anti-CBIR1 Positive CD Dermot P. McGovern*, Stephan R. Targan, Ling Mei, Marla C. Dubinsky, Emebet Mengesha, Carol J. Landers, Jerome I. Rotter, Kent D. Taylor

M2064

Development of Psoriasiform Skin Lesions Under AntiTNF Therapy: A Common Link with IL23R Gene Variants? Isabelle Cleynen*, Liesbet Henckaerts, Karolien Claes, Herma Fidder, Pieter Vandecandelaere, Gert A. Van Assche, Maja Noman, Paul J. Rutgeerts, Severine Vermeire

M2074

OCTN1 L503F Variant Is Associated with Inflammatory Bowel Disease (IBD) in Familial and Sporadic IBD Zhenwu Lin*, Laurie S. Nelson, Lisa S. Poritz, Tong-Yi Li, Kathryn Byrnes, Yunhua Wang, Anthony W. Gebhard, Colin MacNeil, Neal J. Thomas, Walter Koltun

M2075

Functions of MICA*A5.1 Allele in Ulcerative Colitis in Chinese Patients Bing Xia*, Min Lu, Liuqing Ge, Jie Zhao, Feng Zhou

M2076

Genetic Variants L290P and R381Q of the Interleukin23 Receptor (IL23R) Gene Are Associated with Inflammatory Bowel Disease (IBD) in a Familial and Sporadic IBD Zhenwu Lin*, Lisa S. Poritz, Tong-Yi Li, Kathryn Byrnes, Yunhua Wang, Anthony W. Gebhard, Colin MacNeil, Neal J. Thomas, Walter Koltun

M2065

Crohn's Associated Genes ATG16L1 and IRGM Are Not Associated with Granuloma Formation Simone C. Wolfkamp*, Pieter C. Stokkers, Anje A. Te Velde

M2066

Evaluation of Global Gene Expression in Rectal Mucosa Obtained By a Non-Invasive Technique in Patients with Ulcerative Colitis Yakov Gitin*, Francis A. Farraye, Xiaoling Zhang, Gang Liu, Avrum Spira, Jerome S. Brody

M2077

Evidence for Genetic Heterogeneity in Dutch Caucasian and Spanish Galician Crohn's Disease Patients Sander Ouburg*, Manuel Barreiro, Bart Crusius, Ad A. van Bodegraven, Enrique Dominguez-Munoz, Amado S. Peña, Servaas A. Morré

M2067

Candidate Gene Approach Identifies CNR2 Gene As Associated with Crohn's Disease: Assigned Haplotypes, Protein Expression, and Functional Data As Defined By Novel Use of Lymphoblastoid Cell Lines David A. Ziring*, Kent D. Taylor, Jerome I. Rotter, Stephan R. Targan, Jonathan Braun

M2078

IL-23 Receptor (IL-23R) Gene Protects Against Crohn's Disease in Hungarian Patients Peter L. Lakatos*, Szamosi Tamas, Aniko Szilvasi, Laszlo Lakatos, Agota Kovacs, Tamas Molnar, Istvan Altorjay, Maria Papp, Zsolt Tulassay, Pal Miheller, Janos Papp, Hungarian IBD Study Group, Hajnalka Andrikovics

M2068

Relevance of Drug-Metabolizing and Cytokine Gene Polymorphisms On IBD Susceptibility to Non-Steroideal Anti-Inflammatory Drugs Maria Asuncion Garcia-Gonzalez*, María Teresa Arroyo, Mireia Peñalva, Fernando Gomollon, Mark Strunk, Elena Piazuelo, Pilar Jimenez, Julian Panes, Angel I. Lanas

M2079

M2069

Association of the CYP4F2 Gene, a Regulator of Leukotriene B4 (LTB4) with Risk for Crohn's Disease in Children Irina C. Costea*, David R. Mack, David M. Israel, Kenneth Morgan, Alfreda Krupoves, Philippe Lambrette, Colette Deslandres, Guy Grimard, Emile Levy, Ernest G. Seidman, Devendra K. Amre

Interaction Between Seroreactivity to Microbial Antigens and Genetics in Crohn's Disease: Is There a Role for Defensins? Peter L. Lakatos*, Istvan Altorjay, Yvette Mándi, Laszlo Lakatos, Agota Kovacs, Tamas Molnar, Pal Miheller, Zsolt Tulassay, Tamas Szamosi, Janos Papp, Hungarian IBD Study Group, Maria Papp

M2080

Compound Polymorphisms in CARD8 and CIAS1 Predispose to Crohn's Disease in a Swedish Cohort Ida Schoultz, Deepti Verma, Leif Törkvist, Jonas Halfvarson, Maria Lerm, Peter Söderkvist, Johan D. Soderholm*

M2081

Glucocorticoid Receptor Polymorphism in Inflammatory Bowel Disease Emese Mihály*, Péter Gergics, Pál Miheller, Károly Rácz, Zsolt Tulassay

M2082

Association Between Toll-Like 4, Cd14 Polymorphisms and Inflammatory Bowel Disease in Turkish Population Hakan Akin*, Filiz T. Özdemir, Özlen Atug, Gulgun Tahan, Fatih Eren, Bilgi Baca, Ismail Hamzaoglu, Hulya O. Hamzaoglu, Nurdan Tozun

M2070

M2071

M2072

M2073

The Polymorphisms of Interleukin-17a and -17f Are Associated with the Susceptibility to Ulcerative Colitis Tomiyasu Arisawa*, Tomomitsu Tahara, Tomoyuki Shibata, MItsuo Nagasaka, Masakatsu Nakamura, Hiroshi Fujita, Yoshio Kamiya, Daisuke Yoshioka, Yuko Arima, Masaaki Okubo, Hiroaki Shimazaki, Ichiro Hirata, Hiroshi Nakano Innate Immune Defects in IRGM1, TLR2, and NOD2 Contribute to Crohn's Disease Risk and Severity in Ashkenazi Jews Juan L. Mendoza*, Melissa Marotta, Ruth Ann Denchy, Asher Kornbluth, Thomas A. Ullman, Lloyd Mayer, Monica Erazo, Sari Feldman, Jane Im, Peter Rubin, Simon Lichtiger, Anthony A. Weiss, James Aisenberg, Kenneth M. Miller, Eric S. Goldstein, Joel J. Bauer, Barry W. Jaffin, Daniel H. Present, Maria T. Abreu, Adele A. Mitchell Association Between Genes Polymorphisms and Infliximab Dependent Patients Dana Duricova*, Natalia Pedersen, Martin Lenicek, Margarita Elkjaer, Pia S. Munkholm, Milan Lukas NOD2/CARD15, Toll-Like Receptor 4, and Toll-Like Receptor 9 Gene Polymorphisms in Spanish and Dutch Patients with Inflammatory Bowel Disease Miquel Sans*, Carolina Figueroa, Bart Crusius, Marta Artieda, Ad A. van Bodegraven, R. A. Van Hogezand, Juan L. Mendoza, Luis Rodrigo, Manuel Barreiro, María Teresa Arroyo, Diego Tejedor, Montserrat Aceituno, Carlos Taxonera, Manuel Alvarez-Lobos, Antonio Martinez, Edgar Ayala, Laureano Simon, Hein W. Verspaget, Amado S. Peña, Julian Panes

M2083

Prediction of Crohn's Disease Aggression Through NOD2CARD15 Sequence Variation Maneesha Bhullar*, Ken Sharpe, Paula Lewis, Bernadette Viney, Gregor Brown, Finlay A. Macrae, Margaret J. Smith

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Liver & Biliary

LIVER AND BILIARY CARCINOMA: ETIOLOGY, DIAGNOSIS, AND NATURAL HISTORY Participants will be able to: • Understand the pathobiology of hepatobiliary carcinomas. M2084

Diagnostic Role of Biliary Pancreatic Elastase for Cholangiocarcinoma in Patients with Cholestasis Chiung-Yu Chen*, Shu-Chu Shiesh, Wei-Lun Tsai

Denotes DDW Poster of Distinction

P-237

M O N D A Y MAY 19

POSTER SESSIONS—COMBINED M2085

Overexpression of the Gamma 2 Chain of Laminin-5 and Matrilysin in the Progression of Human Biliary Tract Cancers Hiroyuki Yamamoto*, Shigeru Sasaki, Chie Miyamoto, Nobuki Miyamoto, Katsuhiko Nosho, Hiroaki Taniguchi, Tadateru Maehata, Kentaro Yamashita, Yasushi Adachi, Yoshiaki Arimura, Fumio Itoh, Kohzoh Imai, Yasuhisa Shinomura

M2086

Comparative Proteomics Analysis to Identify Biomarkers of Hepatocellular Carcinoma Marie Yeo*, Young Mi Na, Dong-Kyu Kim, Hee Jin Park, Kwang Jae Lee, Sung Won Cho

M2087

The Expression Patterns of Growth Factors Are Different in Gallbladder Cancers According to the Gross Type Se-Joon Lee*, Yonghan Paik, DongKi Lee, KwanSik Lee

M2088

Glypican-3, in Conjunction with MMPs and Wnt Signaling Molecules, Plays An Important Role in the Progression of Hepatocellular Carcinoma Chie Miyamoto*, Hiroyuki Yamamoto, Shigeru Sasaki, Noriyuki Akutsu, Hiroaki Taniguchi, Nobuki Miyamoto, Katsuhiko Nosho, Tadateru Maehata, Kentaro Yamashita, Yasushi Adachi, Yoshiaki Arimura, Fumio Itoh, Kohzoh Imai, Yasuhisa Shinomura

M2089

Difference in Presentation in Hepatocellular Carcinoma in Egyptian and US Cohorts Mohamed Amer*, Ed Barber, Fatma Barakat, A. Ibrahim, M. Saleh, M. Salama, E. Rewish, Elliot Alpert, Khaled Selim, Yuko Kono, Tarek Hassanein

M2090

Study of Ultrasonographic Image Using the New Contrast Agent Perflubutane in Patients with Metastatic Liver Tumors Hideki Hayashi*, Youichi Nishigaki, Tomohiro Kato, Akihiko Sugiyama, Eiichi Tomita

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION I: COMBINED

M O N D A Y MAY 19

M2091

The Effect of Major Abdominal Procedure Type On the Incidence and Economic Burden of Deep Vein Thrombosis or Pulmonary Embolism Debraj Mukherjee*, Susan L. Gearhart, Anne O. Lidor, David C. Chang

M2092

Removal of Visceral Fat Improves Metabolic Syndrome and Hepatic Steatosis in Diet-Induced Obese Mice Xavier Dray*, Zhiping Li, Jing Hua, Samuel A. Giday, Susan K. Redding, Eun Ji Shin, Ron J. Wroblewski, Jonathan M. Buscaglia, Priscilla Magno, Dawn Ruben, Michael A. Schweitzer, Jeanne Clark, Anthony N. Kalloo

M2093

Novel Therapeutic Targets in Esophageal Cancer: Impact of Coexpression of Receptor-Tyrosine-Kinases (RTK) and Chemokine Receptor CXCR4 Ines Gockel*, Carl C. Schimanski, Daniel Drescher, Kirsten Frerichs, Markus Moehler, Stefan Biesterfeld, Peter R. Galle, Theodor Junginger

P-238

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL CLINICAL AASLD Poster Session 8:00 AM - 5:00 PM

Association Between BMI and Hepatitis C in the United States Sharif B. Missiha*, Jenny Heathcote, Jun Wang, Kamran Khan

T1014

Hepatitis C Infection (HCV) and Risk of Diabetes Mellitus: A Systematic Review and Meta-Analysis Donna White*, Vlad Ratziu, Hashem B. El-Serag

Sails Pavilion San Diego Convention Center

HCV: EPIDEMIOLOGY AND NATURAL HISTORY T1000

T1013

The Effect of Dialysis On Hepatic Venous Pressure Gradient in Patients with Chronic Hepatitis C Sandeep Khurana, Mark Flasar*, Cinthia Drachenberg, Patrick C. Malloy

MAY 20

T1015

Rate and Predictors of Erythropoietic Growth Factors Use in Chronic Hepatitis C Patients with Treatment Induced Anemia Fasiha Kanwal*, Jennifer R. Kramer, Thomas P. Giordano, Angelique Zeringue, Hashem B. El-Serag

T1016

Burden of Cirrhosis in a National Sample of Patients with Chronic Hepatitis C Fasiha Kanwal*, Jennifer R. Kramer, Steven M. Asch, Thomas P. Giordano, Angelique Zeringue, Hashem B. ElSerag

T1017



Metabolic Syndrome, Not Adipocytokines, Predicts Clinically Significant NAFLD in Non Genotype 3 Chronic Hepatitis C(cHC) Jagdish S. Nachnani, Sharad C. Mathur, Ryan M. Taylor, Peggy Callahan, Prashant K. Pandya*

Quality of Care in Patients with Chronic Hepatitis C Virus Infection Fasiha Kanwal*, Steven M. Asch, Mark Schnitzler, Brett Pinsky, Bruce R. Bacon

T1018

T1005

An Investigation of Neurocognitive Dysfunction in a Homogenous Cohort of State-Infected Irish Female Hepatitis C Patients Damien Lowry*, Odhran McCarthy, Barbara Coughlan, John P. Crowe

Negative Correlation Between Hepatitis B (HBV) and C (HCV) Viral Load in Co-Infected Persons Chin-Lan Jen, Hwai-I Yang, Chun-Jen Liu, Mei-Hsuan Lee, Uchenna H. Iloeje, Jun Su, San-Lin You, Pei-Jer Chen, Chien-Jen Chen*

T1019

Medical, Psychiatric and Substance Use Comorbidities in HCV and HCV-HIV Coinfected Persons Arslan Kahloon*, Melissa Skanderson, Kathleen Mcginnis, Adeel A. Butt

T1020

HCV Antiviral Treatment Among US Veterans with Chronic Hepatitis C Infection: Patient, Provider, and Facility Predictors Jennifer R. Kramer*, Fasiha Kanwal, Thomas P. Giordano, Peter Richardson, Hashem B. El-Serag

T1021

Liver Biopsy Results and Risk Factors for Advanced Liver Disease in a Large Population-Based Cohort of HCV Carriers Undergoing Liver Biopsy Dana L. Bruden*, Heike Deubner, Michael Bruce, Stephen Livingston, Carol Christensen, Chriss Homan, Thomas Hennessy, James L. Williams, Brian J. McMahon

T1022

Lack of Association Between Chronic Hepatitis C Virus Infection and Chronic Kidney Disease Sumeet Asrani*, Mark Schnitzler, Brett Pinsky, Lisa A. Rocca Rey, Fasiha Kanwal

T1001

T1002

T1004

T1006

Monitoring of Eptfe Coated Transjugular Intrahepatic Portosystemic Shunt Patency By Contrast-Enhanced Ultrasound Daniel von Renteln*, Bettina Riecken, Horst Weiler, Arthur Schmidt, Karel Caca Aquaporin-1 Demonstrates Arterial Capillary Proliferation and Hepatic Sinusoidal Transformation Related to Portal Hypertension in Primary Biliary Cirrhosis Hiroaki Yokomori*, Masaya Oda, Toshifumi Hibi

Histologic Evidence of Active Liver Injury in HBeAgPositive and HBeAg-Negative Chronic Hepatitis B Patients with Normal or Minimally Elevated Alanine Transaminase Ke-Qin Hu*, Eugene Schiff, Kris V. Kowdley, Albert D. Min, Mitchell L. Shiffman, William M. Lee, Zachary D. Goodman, Lauren Dau, Kenneth J. Peschell, John Flaherty

T1007

The Influence of Fatty Load On Liver Stiffness in Chronic Hepatitis C Patients Monica Lupsor*, Radu Badea, Horia Stefanescu, Zeno Spirchez, Horatiu F. Branda, Alexandru Serban, Sorana C. Iancu, Mircea D. Grigorescu

T1008

Liver Stiffness Influences the Hepatic Vein Doppler Waveform in Chronic Hepatitis C Patients Zeno Spirchez*, Monica Lupsor, Horia Stefanescu, Sorana Iancu, Sandu Serban, Radu Badea, Mircea D. Grigorescu

T1009

Use of a Death Adjudication Committee in a Cohort Study of Hepatitis C and HIV Infection Alison M. Coe*, Sheila M. Tumilty, Camilla Graham, C. R. Horsburgh, Gregory Kirk, David Nunes, Alexander Y. Walley, Deborah Cotton

T1010

T1011

T1012

Racial/Ethnic Minorities with Chronic Hepatitis C Virus Infection Have More Severe Fatigue Than White Patients with Chronic Hepatitis C Virus Infection Sabina Berezovskaya, Edmund J. Bini* B-Cell Activating Factor (Baff/Blys) Plays An Important Role in the Natural History of Chronic Hepatitis C Virus Infection Gerond Lake-Bakaar*, Amy W. Lin, Ira M. Jacobson, Andrew Talal

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Clinical Practice

FUNCTIONAL BOWEL DISEASE Participants will be able to: • Be familiar with the burden of functional bowel disease. T1023

Epidemiology of Opioid Bowel Dysfunction and Narcotic Bowel Syndrome in the Community Rok Seon Choung*, G. Richard Locke, Cathy Schleck, Alan R. Zinsmeister, Nicholas J. Talley

Mortality from Hepatitis C in the US: Has the Worst Passed? W. Ray Kim*, Rachel A. Pedersen, Andrew A. Hindman, Carol L. Brosgart, Norah Terrault

Denotes DDW Poster of Distinction

T U E S D A Y

P-239

POSTER SESSIONS—CLINICAL T U E S D A Y MAY 20

T1024



Systematic Review of the Utility of the Manning and ROME Criteria in the Diagnosis of Irritable Bowel Syndrome Alexander C. Ford*, Nicholas J. Talley, Sander Veldhuyzen van Zanten, Nimish Vakil, Paul Moayyedi

T1025

IBS and Outpatient Services: Towards the Development of An Empirical Model of Health Care Utilisation Vikki E. Knott, Jane M. Andrews*, Deborah A. Turnbull, Gerald J. Holtmann

T1026



T1027

Measuring IBS Patient Reported Outcomes with a Single Item Numeric Rating Scale: Results from the PROOF Cohort Brennan M. Spiegel*, Lucinda A. Harris, Susan L. Lucak, Emeran A. Mayer, Bruce D. Naliboff, Roger E. Bolus, Eric Esrailian, William D. Chey, Anthony Lembo, Hetal A. Karsan, Kirsten Tillisch, Gareth S. Dulai, Amy Strickland, Lin Chang Dose-Dependent Therapeutic Efficacy of Acotiamide (Z338) in Patients with Functional Dyspepsia: 100 Mg TID Is An Optimal Dosage Kei Matsueda*, Michio Hongo, Daisuke Sasaki, Motoyasu Kusano, Shigeru Harasawa, Tetsuo Arakawa, Ken Haruma, Takeshi Miwa, Mitsuyoshi Nakashima

T1028

Acotiamide (Z-338) Is a Drug of Choice for Patients with Postprandial Distress Syndrome of Functional Dyspepsia Kei Matsueda*, Michio Hongo, Jan F. Tack, Yoichi Saito, Hiroki Kato

T1029

Development of An Instrument to Assess Treatment Satisfaction in Patients with Chronic Constipation Sheryl L. Szeinbach*, Jason Bratten, Robert W. Baran, Michael P. Jones

T1030

Similarities Between Constipation with and Without Irritable Bowel Syndrome in a California Medicaid (Medi-Cal) Population: Costs Trends By Category in the 12 Months After Diagnosis from 1997 to 2002 Jeonghoon Ahn, Richard A. Brook*, Mike B. Nichol, Jeff McCombs, Nicholas J. Talley, G. Richard Locke, Robert W. Baran

T1031

T1032

Rikkunshi-to Attenuates Adverse Gastrointestinal Symptoms Induced By Milnacipran and Potentiates Its Antidepressant Effect Takakazu Oka

T1037

Structural Validation of a Quality of Life Questionnaire (FDDQOL) in Patients with Functional Dyspepsia Reevaluation of a Placebo-Controlled Trial Ahmed Madisch*, Ulrike von Arnim, Jürgen Müller, Bettina R. Vinson, Karin Zeller, Peter Malfertheiner

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Clinical Practice

GI BLEEDING Participants will be able to: • Review recent research in the area of GI bleeding. T1038

Cost-Effectiveness of Proton Pump Inhibition Before Endoscopy in Upper Gastrointestinal Bleeding: A CostEffectiveness Study Alan Barkun*, Viviane Adam

T1039

Lower Gastrointestinal Bleeding in General Population: Preleminary Results of a French Prospective Study Including More Than 1000 Patients Christophe Pilette*, Bruno Bour, Bruno Lesgourgues, Olivier Nouel, Andre-Jean Remy, Frederic Helluwaert, Jean Henrion, Roger Faroux, Gilles Macaigne, Chantal Naouri, David Bernardini, Guy Bellaiche, E. Alexandre Pariente, Herve Hagege

T1040

Stress Bleeding Prophylaxis in Critically Ill Patients: Survey of the Clinical Practice Stefanie Zierhut, Sylvia Siebig, Tanja Bruennler, Falitsa Mandraka, Felix Rockmann, Antje Vasold, Julia Langgartner, Christian E. Wrede, Juergen Schoelmerich, Frank Klebl*

T1041

Complex Antithrombotic Therapy Prescription: Prevalence and Provider Recognition of Gastrointestinal Risks Peter J. Ramsey*, Peter Richardson, Neena S. Abraham

T1042

Risk Factors for More Than One Upper Endoscopy During Hospitalization for Acute Upper Gastrointestinal Hemorrhage Sofyan Radaideh, Jason A. Dominitz, Dawn Provenzale, Faouzi Azzouz, Beverly S. Musick, Thomas F. Imperiale*

T1043

Impact of Missed Opportunities to Confirm Helicobacter pylori Eradication in Peptic Ulcer Disease Frederick J. Gandolfo*, Fritz Francois

T1044

Utility of Point-of Care INR Measurement Prior to Endoscopy in Patients On Warfarin Ravinder S. Dhillon*, Mark Cerefice, Barbara Alpini, Anthony Infantolino, David E. Loren



The Incidence, Spectrum and Management of Complications Encountered During 10 Years Experience with Enterra Therapy for the Treatment of Severe Gastroparesis Irene Sarosiek*, Jameson Forster, Katherine Roeser, Richard McCallum

T1033



How Useful Is Dietary Management in the Treatment of Chronic Constipation? Phyllis J. Stumbo, Donna Hemmingway, Jessica A. Paulson, Kara Seaton, Konrad S. Schulze, Satish S. Rao*

T1045

Prediction of Rebleeding and Mortality in Non Variceal Upper Gastrointestinal Bleeding: Prospective Validation of Rockall and Baylor Scores Rosario Mayorga*, Corina Mayuri

T1034

Quality of Life Is Low in Children with Slow Transit Constipation (STC) Melanie C. Clarke, John M. Hutson, Bridget R. Southwell*

T1046

T1035

Severity of Symptoms and Health Related Quality of Life in Gastroparesis Monik Kowalczyk*, Peter Axelrod, Zeeshan Ramzan, Robert S. Fisher, Henry P. Parkman

FOBT, Not Anemia, May Predict Increased Risk for Gastrointestinal Bleeding in Patients Treated for Acute Myocardial Infarction Renjy Vattasseril*, Wael Eldarawy, Desh Sharma, Saad Adoni, Nizar Hallak, Maurice A. Cerulli

T1036

Health-Related Quality of Life in Adults with Irritable Bowel Syndrome with Constipation: Results of a Combined Analysis of Two Phase 3 Studies with Lubiprostone Douglas A. Drossman*, William D. Chey, Charles Scott, Raymond M. Panas, Ryuji Ueno

P-240

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL AGA Institute Poster Session 8:00 AM - 5:00 PM

T1057

Accelerating Improvement in the Management of Pediatric Inflammatory Bowel Disease Michael D. Kappelman*, Stanley A. Cohen, Wallace Crandall, Lynn F. Duffy, Benjamin D. Gold, John Grunow, Sandra C. Kim, Ian Leibowitz, Peter Margolis, Dev I. Mehta, David E. Milov, M. Susan Moyer, Sarah K. Myers, Ashish S. Patel, Bess T. Schoen, Boris Sudel, Richard B. Colletti

T1058

Appropriateness of Initial Treatment for Severe Crohn's Disease: Application of EPACT Criteria to the EC-IBD European Cohort Pascal Juillerat*, Valérie Pittet, Florian E. Froehlich, JeanJacques Gonvers, Christian Mottet, Christian P. Felley, Bernard Burnand, John-Paul Vader, Reinhold Stockbrugger, Pierre F. Michetti

Sails Pavilion San Diego Convention Center

Sponsored by: Clinical Practice

INFLAMMATORY BOWEL DISEASE Participants will be able to: • Learn more about complications and outcomes of IBD. T1047

Gender Variations in the Incidence of Pediatric Crohn's Disease: A Population-Based Cohort Study Gwenola Vernier-Massouille, Corinne Gower-Rousseau, Luc Dauchet, Dominique Turck, Jean-Louis Dupas, Véronique Merle, Mamadou Balde, Eric Lerebours, Raymond Marti, Jean-Louis Salomez, Antoine Cortot, Jean-Frédéric Colombel*

T1048

No New Safety Signals Identified in Crohn's Disease Patients Treated with Infliximab in An Interim Review of the ENCORE Registry Jean-Frédéric Colombel*, Cosimo Prantera, Paul J. Rutgeerts, Julian Panes, Wolfgang E. Fleig, Geert D'Haens, Bernd Bokemeyer, Usha Barai, Maria Wiekowski

T1049

A Survey Evaluating Patterns of Infliximab Use Amongst Canadian Gastroenterologists: Utilization of the Tailored Design Method Jennifer Jones*, Remo Panaccione, Margaret Russell, Robert J. Hilsden

T1050

Impact of Anti-Tumor Necrosis Factor Therapies On Absence from Work Among Employees with Inflammatory Bowel Disease Heidi C. Waters*, Nathan L. Kleinman, Spencer Borden, Wendy D. Lynch, Harold H. Gardner, Mirza I. Rahman

T1051

Clinical Efficacy of Infliximab in the Management of Postsurgical Recurring Crohn's Disease Naoki Yoshimura*, Takaaki Kawaguchi, Minako Sako, Masakazu Takazoe

T1052

T1053

T1054

T1059



Important Factors When Considering Treatment for Ulcerative Colitis Heidi C. Waters*, Jenna Kelly, Mirza I. Rahman

T1060



Perceived Stigma in IBD: Generalizability of the IBS Perceived Stigma Scale (PSS-IBS) and the Role of Stigma in Psychosocial Function Tiffany Havlicek*, Laurie Keefer, Michele Nealon-Woods, Michael P. Jones

T1061

Improvement in Short Inflammatory Bowel Disease Questionnaire Scores in Adalimumab-Treated Crohn's Disease Patients Who Failed Infliximab (CHOICE Trial) Simon Lichtiger*, Daniel H. Present, Eric Wu, Nicolas Beaulieu, Jeffrey D. Kent, Kathleen G. Lomax, Jingdong Chao, Parvez Mulani

T1062

Improvement in Work Productivity with Adalimumab in Crohn's Disease Patients Who Failed Prior Infliximab: An Analysis of the CHOICE Trial Simon Lichtiger*, Daniel H. Present, Bjorn Persson, Eric Wu, Jeffrey D. Kent, Kathleen G. Lomax, Jingdong Chao, Parvez Mulani

T1063

Association Between Health-Related Quality of Life and Utility Scores from EQ-5D or SF-6D in Crohn's Disease Brian Feagan*, Seng Tan, Martin Brown

Endoscopic Balloon Dilation of Crohn's Strictures: Does the Need of Surgery Depend On Their Location? Thomas Müller*, Bernd Rieder, Albrecht Pfeiffer

AGA Institute Poster Session 8:00 AM - 5:00 PM

Gastroenterologist Visits and Endoscopy Are Associated with Improved Persistence to 5-ASA Therapy Sunanda V. Kane*, Simon H. Magowan, Neil Accortt

Sponsored by: Esophageal, Gastric & Duodenal Disorders

Analysis of Genetic Variants in Non-TPMT Genes to Explain Bone Marrow Toxicity During Azathioprine Therapy in Inflammatory Bowel Disease Konstantinos Katsanos*, Marc Ferrante, Liesbet Henckaerts, Marie Joossens, Ingrid Arijs, Fabian Schnitzler, Herma Fidder, Gert A. Van Assche, Afroditi Katsaraki, Dimitrios K. Christodoulou, Epameinondas V. Tsianos, Paul J. Rutgeerts, Severine Vermeire

T1055

Post Marketing Clinical Experience with Adalimumab in Crohn's Disease Houssam E. Mardini*, Ben Bryson, Deborah R. Flomenhoft, Razvan I. Arsenescu, Willem J. de Villiers

T1056

Clinical Status, Psychosocial Impairments, Provided Health Care Services and Cost of Medication for Inflammatory Bowel Disease (IBD) in Germany: An Online IBD-Registry Bernd Bokemeyer*, Dietrich Hüppe, Marc Düffelmeyer, Tobias Klugmann, Josef Weismüller, Christoph Schmidt, Martin Hoffstadt, Heiner Raspe, Anne Prenzler, Thomas Mittendorf, Susann Conrad

Sails Pavilion San Diego Convention Center

NON-GERD, CLINICAL ACID-PEPTIC & OTHER GASTRODUODENAL DISORDERS Participants will be able to: • Be familiar with the mechanisms that regulate acid-peptic and other gastroduodenal disorders. T1064

Oral Buffered Esomeprazole (BE) in Twice Daily Doses Can Maintain a Sustained pH >6 in Patients with Acute Non Variceal Bleed (ANVB) After Endotherapy: A Clinical Trial with Continuous Intragastric pH Monitoring Rupa Banerjee*, D. N. Reddy, G. V. Rao, Rakesh Kalapala

T1065

Expression and Function of Acid-Sensing Ion Channels in Intestinal Epithelial Cells Xiao Dong*, Kwang Hyun Ko, Ryan Jones, Jimmy Chow, Kim E. Barrett, Hui Dong

T1066

Risk of Upper Gastrointestinal Complications (UGIC) in Patients with a Previous History of Peptic Ulcer Sonia Hernandez-Diaz, Luis A. García Rodríguez*

T1067

Causes of Uncomplicated Peptic Ulcer. A Report of 274 Patients from a Single Danish Center Bo Sondergaard*, Christina Reimer, Peter Bytzer

Denotes DDW Poster of Distinction

P-241

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y

T1068

Perforated Peptic Ulcers in Israel 1995-2004: Unparallel Decrease in the Rates of Perforated Duodenal and Gastric Ulcers Tiberiu Hershcovici*, Ziona Haklai, Ethel-Sherry Gordon, Joseph Zimmerman

T1069

A Comparative Study On the Healing Effects of Rebamipide and Omeprazole in H. pylori - Positive Gastric Ulcer After Eradication Therapy; A Randomized Double-Blinded, Multicenter Trial Kyung Ho Song*, Yong Chan Lee, Jin-Ho Kim, Daiming Fan, Zhi-Zheng Ge, Feng Ji, Min-Hu Chen, Hyun Chae Jung, Jiang Bo, Sang Woo Lee

MAY 20 T1070

T1071

T1072

T1080



Effects of Rabeprazole Sodium and Ranitidine Hydrochloride On Gastric Acidity for 2 Consecutive Weeks: A Randomized, Open-Label, Two-Way Crossover Study in Healthy Subjects Using BRAVO® Capsules Fixed to the Stomach Shoko Ono*, Mototsugu Kato, Yuji Ono, Masahiro Asaka

T1081

Effect of Lubiprostone On Duodenal Mucosal Bicarbonate Secretion Hui Dong*, Cheyanne Contreras, Xiao Dong, Kim E. Barrett

T1082

Lymphocytic Duodenosis: Clinical Presentation and Investigation in a Retrospective Study of 55 Patients Mussarat N. Rahim, Jonathan M. Hoare, Marjorie M. Walker*, Rupert Negus, Jane Macnaughtan

Important Role of Plasma Membrane Ca2+ Channels and Ca2+ Signaling in Acid-Stimulated Duodenal Mucosal Bicarbonate Secretion Kwang Hyun Ko*, Xiao Dong, Jonathan Lee, Hui Dong

T1083

The Changing Pattern of Peptic Ulcer Disease in London Between 1985 and 2006 Nick Powell*, Joel Dunn, Thomas A. Treibel, Huw J. Thomas, Joel Mawdsley, Timothy Orchard, Julian P. Teare, Rupert Negus, Jonathan M. Hoare

Low Prevalence of Microsatellite Instability in Sporadic Duodenal Adenomas D. Ramsoekh*, M. E. Leerdam van, W. Dinjens, E. J. Kuipers

T1084

High Resolution Esophageal Manometry (HRM): Evaluation of the New Diagnostic Criteria for Patients with Achalasia Vien X. Nguyen*, Michael D. Crowell, Cuong C. Nguyen, Hack J. Kim, John K. DiBaise, Virender K. Sharma, Ananya Das

T1085

A Prospective Randomized Controlled Trial of Famotidine and Omperazole: Prevention of Bleeding After EMR and Effect of EMR-Induced Ulcer Healing Kenji Nakamura*, Yasuharu Yamaguchi, Masao Toki, Kei Aoki, Shin-ichi Takahashi

T1086

Providers Disagree About Risk of Adverse Events with PPIs, and Beliefs Predict Adherence with “Best Practices” in Dyspepsia Management Brennan M. Spiegel*, Mary Farid, Martijn G. van Oijen, Loren A. Laine, Colin W. Howden, Eric Esrailian

T1087

Intravenous Esomeprazole Induces a Relevant Reduction of Gastric Secretions Volume After a Single Dose Cristina Nichita*, Abdou El-Wafa, Philippe Maerten, Maribelle Herranz, Natacha Spinelli, Christina Thalmann, Pierre F. Michetti, Gian Dorta

Influence of L-Tryptophan and Melatonin On Gastric Mucosal Damage Induced By Aspirin in Men Peter Konturek*, Krzysztof Celinski, Maria Slomka, Halina Cichoz-Lach, Wladyslaw Bielanski, Stanislaw Konturek

T1073

Rapid Onset of Intragastric Acid Control with Intravenous Esomeprazole in Critically Ill Patients David C. Metz*, Gerard Fulda, Keith M. Olsen, John T. Monyak, Steven G. Simonson, Mark B. Sostek

T1074

Serum Pepsinogen Concentrations in H. pylori-Infected, Non-NSAID-Associated Peptic Ulcers At Different Sites: Ulcers in the Middle Body or More Proximal Serologically Differ from Those More Distally Tomohiko Shimatani*, Seiko Hirokawa, Kazuko Hamai, Yumiko Tawara, Mutsuko Matsumoto, Ayumi Furukawa, Susumu Tazuma, Masaki Inoue

T1075

T1076

T1077

Comparison of Acid-Suppressive Effects of Three Brands of Generic Lansoprazole with Original Lansoprazole: Pharmacodynamic Equivalence Is Not Necessarily Guaranteed By Pharmacokinetic Bioequivalence Tests Tomohiko Shimatani*, Susumu Tazuma, Masaki Inoue Drug-Induced Gastric Dysrhythmia and Emesis in Dogs and Possible Roles of Gastric Electrical Stimulation Xiaoyun Yu, Lei Tu, Xiaohua Hou*, Jie Yang, Geng-Qing Song, Bin Yang, Jiande Chen Occurrence of Intrinsic Factor and Parietal Cell Autoantibodies in Atrophic Body Gastritis Patients with or Without Pernicious Anemia Edith Lahner, Gary L. Norman*, Carola Severi, Susan B. Encabo, Zakera Shums, Giacoma S. Agnello, Lucy Vannella, Gianfranco Delle Fave, Bruno Annibale

T1078

The Validity of a Biomarker Method for Indirect Detection of Gastric Mucosal Atrophy Versus Standard Histopathology Marcis Leja*, Limas Kupcinskas, Jaw-Town Lin, Konrads Funka, Dainius Janciauskas, Agnese Sudraba, Laimas Jonaitis, Audrius Ivanauskas, Han-Mo Chiu

T1079

Acid Inhibition in Early Phase By Intravenous Infusion of Omeprazole and/or Famotidine in Relation to Cytochrome P450 2C19 Genotype Status Mitsushige Sugimoto*, Takahisa Furuta, Chise Kodaira, Masafumi Nishino, Mihoko Yamade, Mutsuhiro Ikuma, Akira Hishida

P-242

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: SCREENING AND DIAGNOSIS (II) Participants will be able to: • Learn more about screening and diagnosis in GI cancers. T1088



Comparison of An Immunochemical Fecal Occult Blood Test Vs Colonoscopy for Colorectal Cancer Screening in the Familiar-Risk Population: A Prospective Randomized Study Marta Carrillo-Palau*, Manuel Hernández-Guerra, Antonio Z. Gimeno-García, Nicolás González, Adolfo Parra-Blanco, David Nicolás-Pérez, Juan Antonio Díaz-Acosta, Alejandro Jiménez, Enrique Quintero

T1089

A Validated Clinical Risk Score Predicts Risk of Colorectal Neoplasm in Asymptomatic Asian Subjects Khay Guan Yeoh*, Khek Yu Ho, Reuben K. Wong, Han-Mo Chiu, Jaw-Town Lin, Ming-Shiang Wu, Feng Zhu, Wai K. Leung, James Y. Lau, Deng-Chyang Wu, Huang-Ming Hu, Jeong-Sik Byeon, Sang Kil Lee, Jin Yong Kim, Ida Hilmi, Khean-Lee Goh, Govind K. Makharia, Murdani Abdullah, Rikiya Fujita, Dizza R. Dujali, Jose D. Sollano, Rungsun Rerknimitr, Joseph J. Sung

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL T1090



Flexible Sigmoidoscopy Plus Fecal Immunochemical Testing for Colorectal Cancer Screening: Update with Extended Follow-Up Jaarke Vannoote*, Wei K. Zhao, Lori C. Sakoda, James E. Allison, Thomas M. Cuff, Lyle Shlager, Jonathan P. Terdiman, Theodore R. Levin

T1091

Synchronous Neoplastic Lesions in Colorectal Cancer. Analysis of Possible Risk Factors Favouring Presentation Ana Borda, Javier Jimenez-Perez*, Miguel A. Munoz-Navas, Jose María Martínez-Peñuela, Carlos Prieto, Cristina Carretero, Fernando Borda

T1092

Analysis of the Age of Diagnosis of Colorectal Carcinoma Ana Borda, Javier Jimenez-Perez*, José María MartínezPeñuela, Miguel A. Munoz-Navas, Carlos Prieto, Maite Betés, Fernando Borda

T1093

Aberrant Crypt Focus Size Predicts Distal Polyp Histopathology Jae Kim*, Ronald J. Ewing, Robert E. Carroll, Xavier Llor, Richard V. Benya

T1094



T1095

Diagnostic Yield of Screening for Colorectal Cancer in the Netherlands; Randomized Controlled Trial Comparing Two Different Forms of Faecal Occult Blood Testing and Sigmoidoscopy Lieke Hol*, Ernst J. Kuipers, Marjolein van Ballegooijen, Anneke van Vuuren, Jaqueline C. Reijerink-Verheij, Alexandra C. van der Togt-van Leeuwen, J. D. Habbema, M. E. Leerdam van Implementation of Colorectal Cancer Screening in the Netherlands: Results of the First 20,000 Pilot Study Anne Floortje van Rijn*, Leo van Rossum, Paul Fockens, Robert Laheij, Evelien Dekker, Jan B. Jansen

T1096

High-Risk Population for Gastric Cancer Development Based On Serum Pepsinogen Status and Lifestyle Factors Yutaka Yamaji*, Hirotsugu Watabe, Takao Kawabe, Toru Mitsushima, Masao Omata

T1097

The Adenoma and Cancer Detection Rate: Do InterEndoscopists' Variations Happen in the Field of a Mass Screening Programme Based On Colonoscopy Following a Positive Faecal Occult Blood Test (FOBT) Result? Jean-François Bretagne*, Françoise Riou, Christine Piette, Emmanuelle Leray, Dorina Bratu, Sylvain Manfredi, Gérard Durand

T1098

Improved Non-Invasive Stool DNA (SDNA) Test to Screen for Colorectal Cancer (CRC): Validation of High Sensitivity and Specificity Steven H. Itzkowitz*, Randall Brand, Lina Jandorf, Linda Rabeneck, Paul C. Schroy, Stephen J. Sontag, David A. Johnson, Sanford Markowitz, John M. Millholland, Kristine H. Durkee, Lawrence Paszat, Barry M. Berger

T1099

Pancreatic Cancer Detection By Stool Testing: Pilot Study Targeting Proteomic Markers Patrick S. Quint*, Jonathan J. Harrington, Ann L. Oberg, Douglas W. Mahoney, Garth D. Nelson, Suresh T. Chari, H. R. Bergen, David A. Ahlquist

T1100

Strategies to Enhance Participation in a Screening Program for Colorectal Cancer in a Mountain Community Sergio Crotta*, Bruna Dagnes, Grazia Grazzini, Carlo Senore

T1101

Screening Behavior, and Attitudes and Beliefs About Colon Cancer Screening in a High-Risk Population: Baseline Data from the Family Health Promotion Project (FHPP) Dennis Ahnen*, Al C. Marcus, Jan Lowery, Dianne M. Finkelstein

T1102

Detection of Colorectal Neoplasia By Stool DNA Testing: High Discrimination with Multi-Marker Quantitation Xuan Jiang, Jonathan J. Harrington, Douglas W. Mahoney, Ann L. Oberg, Mary E. Devens, Julie Simonson, David A. Ahlquist*, Hongzhi Zou

T1103

What Is the Proportion of Screened and Interval Cancers Among Overall Colorectal Cancers Diagnosed in a French District Implying a Mass Screening Programme with Faecal Occult Blood Test (FOBT)? Caroline Jézéquel, Sylvain Manfredi*, Gaud Mallard, Christine Piette, Gérard Durand, Jean-François Bretagne

T1104

Characteristics of Colorectal Adenomas Identified By Colonoscopy, Their Immunochemical Fecal Occult Blood Measurements and Contribution to Test Specificity Paul Rozen*, Rachel Hazazi, Zohar Levi, Amal Waked, Alex Vilkin, Eran Maoz, Shlomo Birkenfeld, Moshe Leshno, Yaron Niv

T1105

A Sensitive Method to Scan Gene Mutations in Stool: Relevance to Detection of Gastrointestinal Neoplasia Hongzhi Zou*, William R. Taylor, Jonathan J. Harrington, Mary E. Devens, Julie Simonson, David A. Ahlquist

T1106

Disclosure of Early Premalignant Changes - the Importance of Unstained Lesions in Chromoendoscopy of the Esophagus Friederike Bernhardt*, Diether Ludwig, Nils Homann

T1107

Staging Anal Cancer: Prospective Comparison of Transrectal Endoscopic Ultrasound and Magnetic Resonance Imaging Susanne D. Otto*, Luu-Nguyen Le, Heinz J. Buhr, Anton J. Kroesen

T1108

Performance of a Quantitative Immunochemical Fecal Occult Blood Test Is Not Affected By Low-Dose Aspirin or NSAIDs or Upper Gastrointestinal Lesions, But May Be Affected By Anticoagulants Zohar Levi*, Paul Rozen, Rachel Hazazi, Alex Vilkin, Amal Waked, Eran Maoz, Shlomo Birkenfeld, Yaron Niv

T1109

Colorectal Cancer Screening with the Addition of Flexible Sigmoidoscopy to Guaiac-Based Fecal Occult Blood Testing: A Population-Based Controlled Trial Bernard Denis*, Isabelle Gendre, Jean Christophe Pfeiffer, Anne Marie Weiss, Frédéric Vagne, André Peter, Philippe Perrin

T1110

A Colorectal Cancer Screening Outreach Using Fecal Immunochemical Tests Pauline A. Mysliwiec*, Steven Courteau, Wei K. Zhao, Elaine H. Chung, Debra R. Maurer, Theodore R. Levin

T1111

Immunological FOBT (IFOBT): Doubling the Number of Detected Colorectal Polyps Within a Population-Wide Screening Program in Western Europe Gernot Leeb*, Andreas Leodolter, Christian Vutuc, Gerald Haidinger, Karl Mach

T1112

Relationship of Proximal Hyperplastic Polyps to Adenomas On Screening Colonoscopy Roy Yen*, Ognian A. Pomakov, Michael D. Sitrin

T1113

Prevalence and Clinicopathological Characteristics of Non-Polypoid Colorectal Neoplasia in Asymptomatic and Average-Risk Chinese Population Han-Mo Chiu*, Jaw-Town Lin, Yi-Chia Lee, Hsiu-Po Wang, Ming-Shiang Wu

T1114

Health Beliefs Outweigh Lack of Knowledge As Barriers to Screening for Colon Cancer Among First Degree Relatives of Colon Cancer Patients Jesse Lachter*, Orna Epel-Baron

Denotes DDW Poster of Distinction

P-243

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y

T1115

Interobserver Variations for the Detection of Atrophy and Intestinal Metaplasia of the Stomach Konrads Funka*, Marcis Leja, Dainius Janciauskas, Viesturs Putnins, Laimas Jonaitis, Agnese Sudraba, Audrius Ivanauskas, Han-Mo Chiu, Ivars Tolmanis, Limas Kupcinskas, Jaw-Town Lin

T1116

High Prevalence of Small Adenomas in a Colorectal Cancer Screening Population Using Primary Colonoscopy Carolina Khalid-de Bakker*, Daisy Jonkers, Silvia Sanduleanu, Wim Hameeteman, Adriaan P. de Bruine, Ad A. Masclee, Reinhold Stockbrugger Stool DNA for Detection of Gastrointestinal Neoplasia: Effect of Lesion Site Judith McElhiney*, William R. Taylor, Hongzhi Zou, Xuan Jiang, Jonathan J. Harrington, Mary E. Devens, Julie Simonson, Suresh T. Chari, Douglas W. Mahoney, David A. Ahlquist

MAY 20 T1117

T1118

CEA in Activated Macrophages: A New Prognostic or Diagnostic Factor for Early Detection of Local Recurrence of Colorectal Neoplasms? Dennis Japink*, Marius Nap, Mathie Leers, Meindert Sosef

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

T1126

Response and Remission At 18 Months of Certolizumab Pegol in Patients with Active Crohn's Disease Is Not Influenced By Rapidity and Magnitude of Induction: An Analysis of PRECiSE 2 and 3 Geert D'Haens*, Krassimir Mitchev, William J. Sandborn

T1127

Adalimumab Safety in Patients with Crohn's Disease and Previous Exposure to Infliximab: CHOICE Trial Simon Lichtiger*, David G. Binion, David C. Wolf, Daniel H. Present, Kathleen G. Lomax, Jeffrey D. Kent, Alexandra T. Cardoso, Winnie Lau

T1129

Predictors of Response in Patients with Active Crohn's Disease Treated with Certolizumab Pegol: A Multiple Regression Analysis of PRECiSE 2 Data Stephen B. Hanauer*, Stefan Schreiber, Ole O. Thomsen, Gary R. Lichtenstein, Ralph Bloomfield, William J. Sandborn

T1130

Efficacy of Delayed-Release Oral Mesalamine in Patients Who Received Previous Ulcerative Colitis Treatment Stephen B. Hanauer*, David Ramsey, William J. Sandborn

T1131

Steroid-Free Remission Over 2 Years in Crohn's Patients Receiving Adalimumab: The Open-Label Extension of the CHARM Trial Stephen B. Hanauer*, Michael A. Kamm, Remo Panaccione, Jean-Frédéric Colombel, William J. Sandborn, Paul F. Pollack, Melissa J. McIlraith

T1132

Pharmacokinetics and Exposure-Response Relationship of Ustekinumab, a Human Monoclonal Antibody to Interleukin 12/23, in Patients with Moderate-to-Severe Crohn's Disease Adedigbo A. Fasanmade*, Omoniyi J. Adedokun, Jewel R. Johanns, Honghui Zhou, Hugh M. Davis, Marion Blank

T1133

Efficacy and Tolerability of Certolizumab Pegol Are Sustained Over 18 Months: Data from PRECiSE 2 and Its Extension Studies (PRECiSE 3 and 4) Stefan Schreiber*, Julian Panes, David Mason, Gary R. Lichtenstein, William J. Sandborn

T1134

Relationship of C-Reactive Protein with Clinical Response Following Therapy with Monoclonal Antibody to IL-12/23p40 (Ustekinumab) in Crohn's Disease Willem J. de Villiers*, Gary Toedter, Yinghua (Grace) Lang, Marion Blank, William J. Sandborn

T1135

Safety of Anti-TNF Therapy in Crohn's Disease: A MetaAnalysis of Placebo-Controlled Trials Laurent Peyrin-Biroulet*, Nicolas de Suray, Pierre Deltenre, William J. Sandborn, Jean-Frédéric Colombel

T1136

Once-Daily MMX® 5-Aminosalicylic Acid Versus TwiceDaily Asacol® for the Maintenance of Remission of Ulcerative Colitis: A Preliminary Analysis Cosimo Prantera, Anna Kohn*, M. Campieri, Renzo Caprilli, Giacomo C. Sturniolo, Maurizio Vecchi, F. Pallone, Mario Cottone, Salvatore Bellinvia

T1137

A Novel High Dose 1g Mesalamine Suppository (Salofalk®) Is As Efficacious As 500mg TID Suppositories in Mild to Moderate Active Ulcerative Proctitis: A Multicenter, Randomized Trial Tilo Andus*, Andreas Kocjan, Moritz Müser, Vladimir Simanenkov, Andrey Baranovsky, Tatyana L. Mikhailova, Tatyana D. Zvyagintseva, Andrey Dorofeyev, Yuriy Lozynskyy, Alexandra Lavy, Ralf Mohrbacher, Roland Greinwald

T1138

Global Safety of Adalimumab in Crohn's Disease Clinical Trials Jean-Frédéric Colombel*, Remo Panaccione, William J. Sandborn, Paul Rutgeerts, Stephen B. Hanauer, Walter Reinisch, Paul F. Pollack, Jeffrey D. Kent, Alexandra T. Cardoso, Winnie Lau

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

CONTROLLED CLINICAL TRIALS IN HUMANS Participants will be able to: • Learn more about the controlled clinical trials in humans. T1119

Long-Term Budesonide Treatment of Collagenous Colitis - a Randomized, Double Blind, Placebo Controlled Trial Ole K. Bonderup*, Jesper B. Hansen, Peter S. Teglbjaerg, Lisbeth A. Christensen, Jan F. Fallingborg

T1120

Re-Induction with Certolizumab Pegol Following Disease Exacerbation During Maintenance Therapy Is Effective to Regain Response and Remission Gary R. Lichtenstein*, Krassimir Mitchev, Geert D'Haens

T1121

Rapid and Sustained Efficacy of Delayed-Release Oral Mesalamine Gary R. Lichtenstein*, David Ramsey, Edward V. Loftus

T1122

Risedronate Protects Against Bone Loss When a Relapse of IBD Is Treated with Steroids Muhammed H. Kriel*, Jonathan H. Tobias, Tom J. Creed, Melanie J. Lockett, Andrew J. Bell, John D. Linehan, Christopher S. Probert

T1123

Oral Budesonide for Maintenance Treatment of Collagenous Colitis: A Randomised, Placebo-Controlled, Double-Blind Trial Stephan Miehlke, Ahmed Madisch*, Birgit Bethke, Andrea Morgner, Gustavo Baretton, Manfred Stolte

T1124

P-244

Once Daily 3g Mesalamine Is the Optimal Dose for Maintaining Clinical Remission in Ulcerative Colitis: A Double-Blind, Double-Dummy, Randomized, Controlled, Dose-Ranging Study Wolfgang Kruis*, Laimas Jonaitis, Juris Pokrotnieks, Gitana Acute, Tatyana L. Mikhailova, Marek Horynski, Marian Bátovský, István Rácz, Karin Kull, Mark Faszczyk, Roland Greinwald, Ralph Mueller

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL T1139

T1140

T1141

T1142

T1143

The ACT Trials: Incremental Benefit of Second and Third Induction Doses of Infliximab in Patients with Moderately-to-Severely Active Ulcerative Colitis (UC) William J. Sandborn*, Paul J. Rutgeerts, Brian Feagan, Walter Reinisch, Allan Olson, Jewel R. Johanns, Yinghua (Grace) Lang, Daniel Rachmilewitz, Stephen B. Hanauer, Gary R. Lichtenstein, Willem J. de Villiers, Daniel H. Present, Bruce E. Sands, Jean-Frédéric Colombel

Response to Certolizumab Pegol Induction Is Not Steroid-Dependent in Patients with Active Crohn's Disease Daniel W. Hommes

T1150

Efficacy of Two Different Weekly Doses of Vitamin D (400 Iu and 50,000 Iu) in Patients with Crohn's Disease in Improving Vitamin D Nutritional Status Kleanthis Dendrinos*, Arthur F. Stucchi, James M. Becker, Tai C. Chen, Jeffrey Mathieu, Timothy Heeren, Alpdogan Kantarci, Amanda Blackwood, Kristen Bushell, Michael Holick, Francis A. Farraye

A Comparison of Different Definitions for Measuring the Time to Initial Symptom Resolution in Active, Mildto-Moderate Ulcerative Colitis William J. Sandborn*, Gary R. Lichtenstein, Robyn G. Karlstadt, Karen Barrett, Raymond E. Joseph

T1151

Co-Administration of Certolizumab Pegol with Immunosuppressants and/or Corticosteroids Is Not Associated with An Increased Risk of Adverse Events with Crohn's Disease: Analysis of Pooled Data Brian Feagan*, Jean-Frédéric Colombel, Daniel H. Present, Ralph Bloomfield, Walter Reinisch

Once-Daily MMX® 5-Aminosalicylic Acid (2.4g/Day) Has a Similar Safety Profile to Twice-Daily Asacol® DelayedRelease Tablets (2.4g/Day): Results of a Superiority Trial for the Maintenance of Remission of Ulcerative Colitis Cosimo Prantera, M. L. Scribano*, Stefano Franchini, Salvatore Bellinvia

T1152

Balsalazide Tablets 3.3g Twice Daily Improves Signs and Symptoms of Mild-to-Moderate Ulcerative Colitis Brian P. Bosworth*, Ronald E. Pruitt, Glenn L. Gordon, Mark Lamet, Audrey L. Shaw, Shirley Huang, Shadreck M. Mareya, William P. Forbes

T1153

Infliximab Treatment for Ulcerative Colitis: Comparable Clinical Response, Clinical Remission, and Mucosal Healing in Patients with Disease Duration < 3 Years Vs ≥ 3 Years Walter Reinisch*, William J. Sandborn, Paul Rutgeerts, Marion Blank, Allan Olson, Jewel R. Johanns, Bruce E. Sands

T1154

Treatment Acceptability in a Randomised Controlled Trial of Once-Daily or Twice-Daily Mesalazine (Pentasa) for the Maintenance of Remission in Ulcerative Colitis Axel U. Dignass, Bernd Bokemeyer*, H. E. Adamek, Michael R. Mross, Lars Vinter-Jensen, N. Boerner, Jouni Silvennoinen, T. G. Tan, M. Oudkerk-Pool, Theo Stijnen, Peter Dietel, Tobias Klugmann, Henri Veerman

T1155

A Randomized Double-Blind Placebo-Controlled Trial of Zoledronic Acid for the Treatment of Osteopenia in Children and Adolescents with Crohn's Disease Anne Marie Sbrocchi*, Sylviane Forget, Celia Rodd

Infliximab Treatment for Ulcerative Colitis: Clinical Response, Clinical Remission, & Mucosal Healing in Patients with Moderate or Severe Disease in the Active Ulcerative Colitis Trials (ACT1 & ACT2) Daniel H. Present*, William J. Sandborn, Paul J. Rutgeerts, Allan Olson, Robert H. Diamond, Jewel R. Johanns, Ronald Hegedus, Omar Dabbous A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Testing CCX282-B in the Treatment of Celiac Disease Gordon Hamilton*, Markku Mäki, Marja-leena Lahdeaho, Madhuri Bhasin, Pirow Bekker, Thomas J. Schall

T1144

Results of a Long-Term Follow-Up Treatment with Delayed Release Phosphatidylcholine in Chronic-Active Ulcerative Colitis Max Karner*, Verena Schmieg, Anja Hanemann, Alexandra Zahn, Annika Braun, Heather Karner, Uta Merle, Robert Ehehalt, Wolfgang Stremmel

T1145

A Double-Blind, Placebo-Controlled, Dose-Escalation, Safety and Pharmacokinetic Study of MDX-1100, a Fully Human Anti-CXCL10 Monoclonal Antibody, in Healthy Subjects Michael Yellin*, Ronald Goldwater, Diann L. Blanset, Pina M. Cardarelli

T1146

T1149

Maintenance Therapy with Once-Daily 2g Mesalazine (Pentasa) Treatment Improves Remission Rates in Subjects with Ulcerative Colitis Compared to Twice Daily 1g Mesalazine: Data from a Randomised Controlled Trial Axel U. Dignass*, Bernd Bokemeyer, H. E. Adamek, Michael R. Mross, Lars Vinter-Jensen, N. Boerner, Jouni Silvennoinen, T. G. Tan, M. Oudkerk-Pool, Theo Stijnen, Peter Dietel, Tobias Klugmann, Henri Veerman

T1147

Twice-Daily Balsalazide Tablets Improve Patient Quality of Life After 2 and 8 Weeks of Treatment: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study David T. Rubin*, Alan A. Rosen, Shahriar Sedghi, Roland D. Shepard, Shadreck M. Mareya, Shirley Huang, Audrey L. Shaw, William P. Forbes

T1148

Safety and Tolerability of Twice-Daily Balsalazide Tablets: Results of a Phase 3, Randomized, DoubleBlind, Placebo-Controlled, Multicenter Study Ronald E. Pruitt*, Alan A. Rosen, Lawrence Wruble, Shahriar Sedghi, Roland D. Shepard, Shadreck M. Mareya, Shirley Huang, Audrey L. Shaw, William P. Forbes

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

EPIDEMIOLOGY AND NATURAL HISTORY Participants will be able to: • Understand the epidemiology and symptoms associated with IBD. T1156

Risk-Aversion Profile of Crohn's Patients: A Feasibility Study for Stem Cell Transplantation Samuel Asfaha*, Michelle Geddes, Yvette Leung, Jan Storek, Shane M. Devlin, Jennifer Jones, Gilaad G. Kaplan, Joan A. Heatherington, Robert J. Hilsden, Paul L. Beck, Remo Panaccione

T1157

A Population-Based Study in North-Western Italy of Drug Consumption in Inflammatory Bowel Disease (IBD). Marco Daperno*, Elga E. Cagliero, Raffaello Sostegni, Anna Nigro, Elena Ercole, Angelo Pera, Rodolfo Rocca, Marilena Paire

Denotes DDW Poster of Distinction

P-245

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y

T1158

Direct Costs of Inflammatory Bowel Disease (IBD): A Population-Based Study in North-Western Italy. Marco Daperno*, Elga E. Cagliero, Raffaello Sostegni, Anna Nigro, Caterina Rigazio, Angelo Pera, Marilena Paire, Rodolfo Rocca

T1159

Pre-Operative Evaluation Underestimates the Frequency of the Penetrating Crohn's Disease (B3) Phenotype Found At Surgery Mark G. Lazarev*, Wolfgang H. Schraut, Kevin E. Kip, Miguel Regueiro

MAY 20 T1160

T1161

T1162

T1163

T1164

T1171

Concomitant Symptoms of Functional Gastrointestinal Disorders (FGIDs) in Patients with Inflammatory Bowel Disease (IBD) Are Associated with Decreased Quality of Life (QoL) Jane M. Andrews*, Antonina A. Mikocka-Walus, Deborah A. Turnbull, David J. Hetzel, Gerald J. Holtmann

T1172

The Impact of Infliximab On Crohn's Disease Behavior and Rates of Surgery: Experience from the University of Pittsburgh Mark G. Lazarev*, Wolfgang H. Schraut, Kevin E. Kip, Miguel Regueiro

Psychological Co-Morbidity and Quality of Life (QoL) Vary Between Inflammatory Bowel Disease (IBD) Cohorts in Different Regions and Amongst IBD and Other Chronic Diseases in the One Region Antonina A. Mikocka-Walus, Jane M. Andrews*, Deborah A. Turnbull, Ian G. Wilson, Gerald J. Holtmann

T1173

Is Pediatric-Onset Crohn's Disease More Severe? Benedicte Arnaud-Pigneur*, Philippe Seksik, Jean-Philippe Girardet, Jacques Cosnes

Beware the Ides of March: Seasonal Variation in Quality of Life (QOL) in Inflammatory Bowel Disease (IBD) Steven J. Brown*, Ross Elliott, Sally Bell, Jarrad Wilson, Mark Lust, William R. Connell

T1174

What Is the Natural History of Inflammatory Bowel Disease-Unclassified (IBDU) After Ileal Pouch Anal Anastomosis (IPAA)? Gil Y. Melmed*, Hanlin L. Wang, Eric A. Vasiliauskas, Marla C. Dubinsky, Andrew Ippoliti, Dermot P. McGovern, Stephan R. Targan, Phillip Fleshner

T1175

Can Crohn's Disease Burn Out? Maya Nourani, Philippe Seksik*, Isabelle Nion-Larmurier, Laurent Beaugerie, Jacques Cosnes

T1176

Predictors of DEXA Use in Patients with Inflammatory Bowel Disease Jason P. Etzel*, Meaghan F. Larson, Judith Collins, Bradley D. Anawalt, Jason A. Dominitz

T1177

New Onset IBD Occurring After Solid-Organ Transplantation Raja Tamaz*, Alain Bitton, Ernest G. Seidman, Marc Deschenes, Mickael Bouin, Denis Marleau

T1178

Influence of Primary Sclerosing Cholangitis (PSC) On Ulcerative Colitis (UC) Disease Activity Alicia M. Sambuelli*, Anibal H. Gil, Silvia M. Negreira, Sergio Huernos, Silvina A. Goncalves, Pablo Tirado, Mariano Cartier, Raquel Abecasis, Ruben Terg

T1179

Is Socio-Economic Deprivation Associated with a More Severe Crohn's Disease? Stéphane Nahon*, Gilles Macaigne, Mehran Howaizi, Antoine Fleury, A. Baju, Christophe Locher, Cécile Poupardin, Pierre Lahmek

T1180

Crohn's Disease Complications in Patients with Small Intestinal Strictures: Effects of Disease Modifying Therapy Darashana Punglia*, Jeremy Adler, Maneesh Dave, Paul L. Sonda, Joel F. Platt, Ellen M. Zimmermann

T1181

Surgery Rate in Patients with Crohn's Disease with Regard to Long-Term Clinical Outcome of Infliximab Treatment Natalia Pedersen*, Dana Duricova, Martin Lenicek, Margarita Elkjaer, Milan Lukas, Pia S. Munkholm

T1182

Increased Risk of Arterial Thrombotic Events in Inflammatory Bowel Disease Christina Ha*, Simon H. Magowan, Neil Accortt, Jiajing Chen, Christian D. Stone

T1183

Environmental and Dietary Risk Factors in Microscopic Colitis: A Case-Control Study Cyrus P. Tamboli*, Laura D. Aker, M. Bridget Zimmerman, Phyllis J. Stumbo, Frank A. Mitros

T1184

Similar Monthly Fluctuations of Enteric Infections and Inflammatory Bowel Disease Amnon Sonnenberg

The Concentration and Proportion of Key Bacterial Groups of the Faecal Microbiota Are Different Between Smokers and Non-Smokers with Active Crohn's Disease Andreas Koutsoumpas*, Charlotte R. Hedin, Siew C. Ng, Michael A. Kamm, Jeremy D. Sanderson, Stella C. Knight, Andrew J. Stagg, Alastair Forbes, James O. Lindsay, Kevin Whelan Intestinal Permeability, Fecal Calprotectin and CARD 15 Mutations in First Degree Relatives of Crohn's Disease Patients Renata D'Incà*, Lydia Oliva, Anna Latiano, Francesca Lamboglia, Maria G. Vettorato, Tiziana Slongo, Vito Annese, Giacomo C. Sturniolo Surgery in a Prospectively Followed Cohort of Pediatric Patients with Crohn's Disease (CD) Marc E. Schaefer*, Jeffrey S. Hyams, James Markowitz, David R. Mack, Anne M. Griffiths, Anthony R. Otley, Athos Bousvaros, David Keljo, Jonathan Evans, Marian D. Pfefferkorn, Marsha H. Kay, Petar Mamula, Joel R. Rosh, Ryan S. Carvalho, Subra Kugathasan, M. Susan Moyer, Wallace Crandall, Neal S. LeLeiko

T1165

Hearsay: Is Patient Self-Report of Health Care Utilization Accurate? Teresa Longobardi*, Charles N. Bernstein

T1166

A Population-Based Case Control Study of Potential Risk Factors for IBD Maria P. Lopez*, Jose L. Perez, Conrado Fernandez, Teresa Perez, Marta Fernandez, Ana Barbado

T1167

T1168

T1169

T1170

P-246

Does It Matter Where You Are Hospitalized for Inflammatory Bowel Disease? A Nationwide Analysis of Hospital Volume Ashwin N. Ananthakrishnan*, Emily L. McGinley, David G. Binion Inflammatory Bowel Disease in the Elderly Is Associated with Worse Outcomes: A National Study of Hospitalizations Ashwin N. Ananthakrishnan*, Emily L. McGinley, David G. Binion De Novo Inflammatory Bowel Disease After Solid Organ Transplantation: More Than Just a PSC Phenomenon Chris Shepela The Clinical Course of Inflammatory Bowel Disease After Solid Organ Transplantation Chris Shepela*, Aalia Saeed

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL T1185

Crohn's Disease and Early Exposure to Domestic Cold Fatemeh Malekzadeh, Corinne Alberti, Mehdi Nouraei, Homayoun Vahedi, Isabelle Zaccaria, Ulrich Meinzer, Siavosh Nasseri-Moghaddam, Rassol Sotoodehmanesh, Sara Momenzadeh, Reza Khaleghnejad, Shahrooz Rashtak, Golrokh Olfati, Reza Malekzadeh*, Jean-Pierre Hugot

T1186

Perianal Diseases in Crohn's Disease: A Korean Study Byong Duk Ye*, Suk-Kyun Yang, Yun Kyung Cho, Seunghyun Kwon, Benjamin Kim, Jeong-Sik Byeon, SeungJae Myung, Chang Sik Yu, Jin-Ho Kim

T1187

Natural History of Portuguese Crohn's Disease Patients Fernando Magro*, Francisco Portela, Paula Lago, João Deus, Ana Vieira, Paula Peixe, Isabelle Cremers, Jose Cotter, Marilia Cravo, Lourdes Tavares, Jorge Reis, Raquel Gonçalves, Paulo M. Caldeira, Horacio Lopes, Paula Ministro, Laura Carvalho, Luís Azevedo, Altamiro da Costa Pereira

T1188

The Effect of Oral Contraceptives On Inflammatory Bowel Disease - a Meta-Analysis Vandana Khungar

T1189

The Incidence of Inflammatory Bowel Disease in a Rural Region of Southern Germany - First Results of a Prospective Population Based Study Claudia Ott*, Florian Obermeier, Sabine Thieler, Juergen Schoelmerich, Gerhard Rogler, Antje Timmer

T1190

Influence of Rural/Urban Environment in the Severity of Inflammatory Bowel Disease Manuel Barreiro*, Ana Echarri, Daniel Carpio, Santos Pereira, Javier Castro, Rocío Ferreiro, Victoria Alvarez, Aurelio Lorenzo

T1191

T1192

Increasing Crohn's Disease Severity Over Time: Correlating Interval to First Surgery with Decade of Diagnosis Dawn B. Beaulieu*, Mark Mulcaire-Jones, Ashwin N. Ananthakrishnan, Mazen Issa, Joshua F. Knox, Susan Skaros, Kathryn Lemke, Jasmohan S. Bajaj, Mary F. Otterson, David G. Binion Relationship Between Inflammatory Bowel Disease and Perinatal Factors May-Bente Bengtson*, Inger Camilla Solberg, Geir Aamodt, Morten H. Vatn

T1193

Inflammatory Bowel Disease in HIV Seropositive Individuals: Analysis of a Large Cohort Jonathan Landy, Brian Gazzard, Marcus Harbord*

T1195

Ulcerative Colitis in a South-European Country. A National Perspective Francisco Portela*, Fernando Magro, Paula Lago, Jose Cotter, Isabelle Cremers, João Deus, Ana Vieira, Horacio Lopes, Paulo M. Caldeira, Luísa Barros, Jorge Reis, Laura Carvalho, Raquel Gonçalves, Mario J. Campos, Paula Ministro, Maria A. Duarte, Luís Azevedo, Altamiro da Costa Pereira

T1196

Reduced Clinical Activity During the Course of Ulcerative Colitis Birgit Zahradka*, Albrecht Holle, Stefan Liebe, Joerg Emmrich

T1197

A Risk-Benefit Analysis of Adalimumab vs. Standard of Care in Patients with Crohn's Disease Edward V. Loftus*, Jean-Frédéric Colombel, Scott J. Johnson, Eric Wu, Jingdong Chao, Parvez Mulani

T1198

Prevalence of Hepatitis B (HBV) and C (HCV) in Inflammatory Bowel Disease (IBD): A Transversal Multicentre Spanish Study Carme Loras*, Maria Esteve, Cristina Saro, Ferran Gonzalez-Huix, Olga Merino, Miguel Minguez, Jesus Barrio, Antonio Bernal, Marta Luna, Ana Gutierrez, Marta Piqueras, Daniel Ginard, Xavier Calvet, Luis Bujanda, Agueda Abad, Miquel Torres, Montse Andreu, Julian Panes, Josep Maria Viver

T1199

Association Between Vitamin B12 Levels and Colectomy in Ulcerative Colitis Mazen Issa*, Ashwin N. Ananthakrishnan, Dawn B. Beaulieu, Mark Mulcaire-Jones, Joshua F. Knox, Susan Skaros, Kathryn Lemke, Sarah J. Lundeen, Mary F. Otterson, David G. Binion

T1200

Differences in Severity of IBD in Patients from Coastal/ Non Coastal Towns Daniel Carpio*, Ana Echarri, Manuel Barreiro, Santos Pereira, Victoria Alvarez, Rocío Ferreiro, Aurelio Lorenzo, Javier Castro

T1201

IBD in Adolescents: A Case Control Study of Disease Extent and Therapeutic Strategy Richard Dawson, Mike Hefferon, Nick Croft, James O. Lindsay*

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IBD: IMMUNE ACTIVATION AND REGULATION Participants will be able to: • Learn more about activation and regulation. T1202



TLR8 Signaling Inhibits the Expression of the IBDAssociated Cytokine TL1A (TNFSF15) in Human Monocytes Masayuki Saruta*, Kathrin S. Michelsen, Qi Yu, Lisa S. Thomas, Carol J. Landers, Stephan R. Targan

T1204

Colitogenic CD4+ T Cells Convert to Regulatory Cells to Suppress Colitis in the Process of the Immunosenescence Teruji Totsuka*, Takanori Kanai, Yasuhiro Nemoto, Takayuki Tomita, Mamoru Watanabe

T1205



Glucagon-Like Peptide-2 Improves Healing of TNBS Colitis By Altering Immune Regulatory Cell Signaling in the Lamina Propria Catherine Ivory*, Laurie E. Wallace, Elaine de Heuvel, David Sigalet

T1206

LPS-Induced Reductions of Monocyte/Macrophage PPARγ Levels Cause NOD2 Upregulation and Paradoxical Suppression of NOD2 Signaling Katherine L. Schaefer, Gianni Harris, Lawrence J. Saubermann*

T1207

FTY720 Suppresses the Development of Colitis in Lymphoid-Null Mice By Trapping Colitogenic CD4+ T Cells in Bone Marrow Toshimitsu Fujii*, Takayuki Tomita, Takanori Kanai, Yasuhiro Nemoto, Teruji Totsuka, Mamoru Watanabe

T1208

Anti-Human CD2 MAb Treatment Protects from Colitis in a Humanized Animal Model Anja A. Kuehl*, Christoph Loddenkemper, Katja Grollich, Nina N. Pawlowski, Martin Zeitz, Joerg C. Hoffmann



Denotes DDW Poster of Distinction

P-247

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y

T1209

T1210

MAY 20 T1211

T1212

T1213

New Mechanism of Action for Anti-TNF Therapy in IBD: Induction of FOXP3+CD4+CD25+ and FOXP3+CD4+Cd25- T Cells in Crohn's Disease and Ulcerative Colitis Zhe Li*, Dominique M. Bullens, Severine Vermeire, Maja Noman, Lieve, Coorevits, Paul J. Rutgeerts, Jan L. Ceuppens, Gert A. Van Assche TLR Signaling Inhibits Fasl-Mediated Apoptosis in Human Treg Cells: Implications for Crohn's Disease Meher Rahman*, Yuning Xiong, Phyllis A. Svingen, Laurence J. Egan, William Faubion Clinical Relevance of IgG Antibodies Against Food Antigen in Crohn's Disease - a Double Blind Cross Over Diet Intervention Study Susanne Bentz*, Martin Hausmann, Sabine Paul, Werner Falk, Florian Obermeier, Jürgen Schölmerich, Gerhard Rogler Upregulation of E3 Ubiquitin Ligases Related to T Cell Anergy in CD4+ T Cells Isolated from Patients with Ulcerative Colitis in Remission Satoshi Egawa*, Hideki Iijima, Shinichiro Shinzaki, Sachiko Nakajima, Jumpei Kondo, Shuji Ishii, Toshiyuki Yoshio, Tsutomu Nishida, Yoshimi Kakiuchi, Tatsuya Kanto, Masahiko Tsujii, Shingo Tsuji, Norio Hayashi In Silico Analysis of T-Bet Binding Sites in Peripheral Blood Mononuclear Cells in Patients with Inflammatory Bowel Disease (IBD) Nielsen Q. Fernandez-Becker*, Alan C. Moss

T1214

Peripheral Blood from Crohn's Disease Patients Demonstrate Both IL-17 Expressing CD4+ Lymphocytes and IL-17 and Interferon-Gamma Double Expressing CD4+ Lymphocytes Vinod K. Patel*, Vieira L. Pedro, Gavin Screaton, Julian R. Walters, Subrata Ghosh

T1215

Adipokines and Immunity. On the Interplay Between Adipose Tissue and T Lymphocytes Arvind Batra*, Besir Okur, Jakob Ihbe, Thorsten Stroh, Rainer Glauben, Inka Fedke, Martin Zeitz, Britta Siegmund

T1216

DNA Methylation Status of IFNG Correlates with pANCA Reactivity in UC Patients Rivkah Gonsky*, Richard L. Deem, Carol J. Landers, Carrie A. Derkowski, Stephan R. Targan

T1217

A Novel Population of CD56+ HLA-DR+ Colonic Lamina Propria Cells Is Associated with Inflammation in Ulcerative Colitis Siew C. Ng*, Sophie Plamondon, Hafid O. Al-Hassi, Nicholas R. English, Nichola L. Gellatly, Michael A. Kamm, Stella C. Knight, Andrew J. Stagg

T1218

Intestinal Dendritic Cells in Ulcerative Colitis Have Altered CD103 (Alpha-E) Expression - in Support of Dysregulation in Gut-Homing Siew C. Ng*, Sophie Plamondon, Michael A. Kamm, Stella C. Knight, Andrew J. Stagg

T1219

Increased Expression of L-PGDS May Possibly Relate to Proinflammatory Roles in Colonic Mucosa of Ulcerative Colitis Patients Ryota Hokari*, Hisayuki Matsunaga, Chikako Watanabe, Shunsuke Komoto, Masaaki Higashiyama, Mitsuyasu Nakamura, Chie Kurihara, Yoshikiyo Okada, Shigeaki Nagao, Atsushi Kawaguchi, Yoshikazu Tsuzuki, Soichiro Miura

T1220

P-248

Negative Feedback Regulation of Pathogenic CD4+ T Cells By Increased Granulopoiesis Yasuhiro Nemoto*, Takanori Kanai, Shuji Tohda, Teruji Totsuka, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Fukuda, Hideo Yagita, Mamoru Watanabe

T1221

Deletion of P-Selectin Glycoprotein1 Accelerates the Onset and Worsens IL-10-/- Colitis Jeffrey Brown*, Goo Lee, Gery Grimm, Terrence A. Barrett

T1222

NOD2-Mediated Innate Immune Response in Mucosal Biopsies of Children with Active Crohn's Disease Laura Stronati*, Anna Negroni, Maria Pierdomenico, Ilaria Menghi, Giulia Maiella, Osvaldo Borrelli, Salvatore Cucchiara

T1223

Unraveling the Link Between Solid Organ Transplantation and the Increased Risk for Developing Inflammatory Bowel Disease, Microscopic Colitis and Celiac Disease Paul L. Beck*, Gary R. Martin, Yan Li, Josee F. Wong, Stefan J. Urbanski

T1224

Phenotypical and Functional Study of Ghrelin and Its Receptor in the Pathogenesis of Crohn's Disease Shuhei Hosomi*, Nobuhide Oshitani, Noriko Kamata, Mitsue Sogawa, Hirokazu Yamagami, Kenji Watanabe, Kazunari Tominaga, Toshio Watanabe, Yasuhiro Fujiwara, Tetsuo Arakawa

T1225

Dependence of Antibody-Mediated Presentation of Antigen On FcRn Shuo-Wang Qiao, Kanna Kobayashi*, Finn-Eirik Johansen, Ludvig M. Sollid, Jan Terje Andersen, Edgar L. Milford, Derry C. Roopenian, Wayne I. Lencer, Richard S. Blumberg

T1226

Th17 and Th1 Effector Responses in Crohn's Disease Marisol Veny, Daniel Closa, Miriam Esteller, Josep M. Pique, Julian Panes*, Azucena Salas

T1227

Leukocyte Immunoglobulin-Like Receptors in the Human Colon Greta S. Lee*, Michael C. Grimm, Luis Borges, Nicodemus Tedla

T1228

Differential Regulation of Chemokines By Interleukin 17 in Colonic Epithelial Cells Daniel S. Straus*, Jimmy W. Lee, Kathryn DeFea

T1229

Mucosal CD4+ T Lymphocytes with High CD26 Surface Expression Are Enriched for Memory/Effector Cells and Involved in the Pathogenesis of Inflammatory Bowel Disease Nagamu Inoue*, Tadakazu Hisamatsu, Tetsuro Takayama, Chikao Morimoto, Toshifumi Hibi

T1230

Cytokine Profiles from E. coli Laden Macrophages in IBD Neil B. Rayment, Aikaterini-Dimitra Chairakaki*, Barry Hudspith, liljana petrovska, Gareth Parkes, Jonathan Brostoff, Jeremy D. Sanderson

T1231

Mucosal and Systemic Expression of Leukocyte Specific Transcript (LST)-1/B144 in Human and Experimental Inflammatory Bowel Disease Jan Heidemann*, Moritz Kebschull, Sabrina Werth, Martin Floer, Matthias Bruewer, Wolfram W. Domschke, Andreas Luegering

T1232

Inflammation Is the Main Determinant of Bone Loss in Naïve Patients with Crohn Disease Niksa Turk*, Silvija Cukovic-Cavka, Mirko Korši, Zdenka Turk, Boris n. Vucelic

T1233

Patients with Inflammatory Bowel Disease Exhibit Dysregulated Mucosal Epithelial and Immune Responses to Bacterial DNA Phil Bach*, Hugo Diaz, Kevin St. Arnaud, Richard Fedorak, Karen Madsen

T1234

Autoimmunity in Ulcerative Colitis: TNF-α and Bacterial Lipopolysaccharide Induce Expression of the Autoantigen Human Tropomyosin Isoform 5 Ioannis K. Oikonomou*, Manisha Bajpai, Kiron M. Das

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL T1235

Subcutaneous Injection of E. coli in Human Subjects Demonstrates Excessive Acute Inflammation and Delayed Resolution in Ulcerative Colitis Farooq Rahman*, Bu'Hussain Hayee, Daniel J. Marks, Andrew M. Smith, Stuart L. Bloom, Anthony Segal

T1236

Agalactosyl IgG Observed in Inflammatory Bowel Disease Is Associated with Enhancement of AntibodyDependent Phagocytosis in Human Monocytic Cell Line Hideki Iijima*, Shinichiro Shinzaki, Satoshi Egawa, Sachiko Nakajima, Jumpei Kondo, Shuji Ishii, Yoshimi Kakiuchi, Tsutomu Nishida, Tatsuya Kanto, Masahiko Tsujii, Takatoshi Nakagawa, Akihiro Kondo, Eiji Miyoshi, Shingo Tsuji, Norio Hayashi

T1237

T1238

C-Terminal Peptide of Human Tropomyosin Isoform 5 (hTM5) Is a Dominant Epitope Involved in Humoral and Cellular Immune Response in Ulcerative Colitis Xin Geng*, Jianying Liu, Kiron M. Das Fecal Microbiota Alterations in Inflammatory Bowel Disease (IBD): Decrease of Faecalibacterium prausnitzii But No Quantitative Variation of Escherichia coli Harry Sokol*, Philippe Seksik, Jean-Pierre Furet, Olivier Firmesse, Denis Mariat, Laurent Beaugerie, Jacques Cosnes, Gérard Corthier, Philippe R. Marteau, Joel M. Dore

T1239

Infliximab in Inflammatory Bowel Disease: ‘Can We Heal Two Disease with One Drug?' Sundaram G. Veerappan*, Martin Healy, J Bernard Walsh, Mary Kennedy, Colm A. O'Morain, Barbara M. Ryan, Jacqueline Daly

T1240

Context-Dependent Splicing of Two Novel 5 Prime Untranslated Exons Contributes to the Complex Regulation of NOD2 Protein Expression in Intestinal Inflammation Philip C. Rosenstiel*, Klaus Huse, Andre Franke, Jochen Hampe, Roland Roberts, Christopher G. Mathew, Mathias Platzer, Stefan Schreiber

AGA Institute Poster Session 8:00 AM - 5:00 PM

T1244

Gap Junction Intercellular Communication Plays a Central Role in the Innate Immune Response of the Intestinal Epithelial Barrier Anna Nierobis, Daniel K. Podolsky, Elke Cario*

T1245

The Effect of NOD2 Activation On TLR2 Mediated Cytokine Responses Is Dependent On Activation Dose and NOD2 Genotype Michelle Borm, Ad A. van Bodegraven, Chris J. Mulder, Georg Kraal, Gerd Bouma*

T1246

Toll-Like Receptor 4 Mediates Induction of Inflammatory Pathway By Food Additive Carrageenan in Human Colonic Epithelial Cells Sumit Bhattacharyya, Sangeeta Tyagi, Pradeep K. Dudeja, Joanne K. Tobacman*

T1247

Toll-Like Receptor 5 Engagement with Flagellin Mediating the Innate Immunity Elicits Anti-Tumor Activity in Mouse Xenograft Model of Human Colon Cancer Sang Hoon Rhee*, Eunok Im, Yoon Jeong Choi, Charalabos Pothoulakis

T1248

Regulated Roles of Paneth Cell α-Defensin in Mouse Small Intestine Rie Fukaya*, Naoki Sakai, Tokiyoshi Ayabe

T1249

Tribbles 2 (Trib2), a Novel Regulator in Toll-Like Receptor 5 Signaling, Is Decreased in Inflamed Intestinal Mucosa Shu-Chen Wei*, Ian M. Rosenberg, Zhifang Cao, Alan Huett, Ramnik J. Xavier, Daniel K. Podolsky

T1250

Luminal Uptake of L-Arginine By C. Parvum Infected Porcine Ileum Is Promoted By Epithelial Induction of Arginase II and Stimulates Prostaglandin-Dependent Secretory Diarrhea Jody L. Gookin*, Derek M. Foster, Stephen H. Stauffer, Maria R. Stone (Coccaro)

T1251

Antimicrobial Host Defense in the Upper Gastrointestinal Tract Yoshio Hosaka*, Maureen J. Koslowski, Sabine Nuding, Guoxing Wang, Miriam Schlee, Christian Schäfer, Katunori Saigenji, Eduard Stange, Jan Wehkamp

T1252

Membrane-Bound CD147/EMMPRIN Interacts with NOD2 and Contributes to Recognition of Bacterial Cytoinvasion Andreas Till*, Braeutigam Karen, Christian Sina, Gunnar Jacobs, Dirk Seegert, Trinad Chakraborty, Stefan Schreiber, Philip C. Rosenstiel

T1253

Mucus Protects the Colon By Separating Bacteria from the Epithelium Malin E. Johansson*, Gunnar C. Hansson

T1254

IL-1r Signaling Inhibits Colonic Inflammation By Mediating TLR-9-Dependent Type I IFN Production Jose M. Gonzalez-Navajas*, Jongdae Lee, Mandy Yu, Jason k. Law, Angela Jang, Scott Herdman, Eyal Raz

T1255

Intestinal CD5+ B Cells Produce IL-10 and TGF-β Via Toll-Like Receptor-Mediated Signaling Yoshiyuki Mishima*, Shunji Ishihara, Md M. Aziz, Mohammad A. Rumi, Naoki Oshima, Chikara Kadota, Ichiro Moriyama, Yong-Yu Li, Aya Ohtani, Akihiko Oka, Yasunori Kadowaki, Yuji Amano, Yoshikazu Kinoshita

T1256

Akap13 a RHOA GTPase-Specific Guanine Exchange Factor Is a Regulator of Intestinal Inflammation and Epithelial Cell Function Oren Shibolet*, Cosmas Giallourakis, Tobias Mueller, Ian M. Rosenberg, Ramnik J. Xavier, Daniel K. Podolsky

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

MUCOSAL INNATE IMMUNE FUNCTION AND INNATE HOST DEFENSE Participants will be able to: • Be familiar with the basic aspects of mucosal innate immune responses and innate host defense. T1241



Microsomal Triglyceride Transfer Protein Regulates CD1d-Restricted Antigen Presentation of Hepatocytes and Controls Natural Killer T Cell Homeostasis Via CD1d-Mediated Apoptosis Sebastian Zeissig*, Arthur Kaser, Stephanie K. Dougan, Richard S. Blumberg

T1242



Selective Influence of Tcf-4 Mediated Wnt Signaling On Intestinal Innate and Adaptive Immunity of Ileal Crohn's Disease Maureen J. Koslowski*, Guoxing Wang, Irmgard E. Kuebler, Michael Gersemann, Klaus Fellermann, Eduard Stange, Jan Wehkamp

T1243

NOD2 Activation By Muramyl Dipeptide Induces Autophagy in Dendritic Cells in An ATG16l1 Dependent Pathway Rachel M. Cooney*, John S. Baker, Alison Simmons, Derek P. Jewell

Denotes DDW Poster of Distinction

P-249

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y

T1257

T1258

MAY 20 T1259

Dual Effect of a Novel Toll-Like Receptor 4 (TLR4) Antagonist in Acute Murine Colitis Ryan Ungaro*, Masayuki Fukata, David Hsu, Yasmin Hernandez, Keith J. Breglio, Anli Chen, Ruliang Xu, Greg Elson, Marie Kosco-Vilbois, Maria T. Abreu Phagocyte-Specific S100 Proteins Are Activators of Pattern Recognition Receptors and Released During Active Inflammatory Bowel Disease Dirk Foell*, Zhigang Ren, Helmut Wittkowski, Jan Daebritz, Jan Heidemann, Johannes Roth, Thomas J. Borody, Robert Clancy Mucosal Non-Immune Cells Produce Pro-Inflammatory Mediators in Response to Toll-Like (TLRS) and NODLike Receptor (NLRS) Ligands: Mesenchymal and Endothelial Cells As Novel Players of the Gut Innate Immunity Response Franco Scaldaferri*, Manijeh Phillips, Melanie Rhee, Gail West, Sean Kessler, Christine McDonald, Claudio Fiocchi

AGA Institute Poster Session 8:00 AM - 5:00 PM

AGA Institute Poster Session 8:00 AM - 5:00 PM Sponsored by: Intestinal Disorders

BASIC ADVANCES IN CELIAC DISEASE AND OTHER GENETIC DISORDERS Participants will be able to: • Evaluate basic advances in celiac disease and various genetic disorders. T1267

Celiac Disease-Specific Autoantibodies Targeted Against Transglutaminase 2 Increase Endothelial Permeability In Vitro Essi Myrsky, Tiina Rauhavirta, Ilma Korponay-Szabo, Katri Kaukinen, Markku Mäki, Katri Lindfors*

T1268

Mucosal Addressin Cell Adhesion Molecule-1 in Celiac Disease Antonio Di Sabatino*, Laura Rovedatti, Paolo Biancheri, Manuela Rosado, Laura Cantoro, Rita Carsetti, Gino R. Corazza, Thomas T. MacDonald

T1269

Effects of Synthetic Zot Peptide Analog At-1002 and Inhibitor at-1001 On Gluten Induced Alterations in Barrier Function and Macrophage Recruitment in HLAHCD4/DQ8 Mice Elena F. Verdu*, Jane Natividad, Xianxi Huang, Chella S. David, Joseph a. Murray, Blake M. Paterson, Sefik S. Alkan, Alessio Fasano

T1270

Gliadin Induced Increase in Intestinal Epithelial Permeability Is Independent of MEK Alex Staudacher, Barry C. Powell, Guy R. Sander*

T1271

Enhanced Levels of Interleukin -1beta in Stools from Children with Inflammatory Bowel Disease, But No Local Production in Children with Coeliac Disease Tony Hansson*, Helene Lettesjo, Christer G. Peterson, BrittInger Nyberg, Ingrid Dahlbom, Anders Dannaeus

T1272

Role of NKT Cell-Driven IFN-γ in Postoperative Adhesion Formation Hisashi Kosaka*, Tomohiro Yoshimoto, Kenji Nakanishi, Jiro Fujimoto

T1273

CD30 Antigen Expression Is Involved in Celiac Disease Natalia Periolo, Laura Guillen, Marcos Barboza, Sonia Niveloni, Eduardo Mauriño, Julio C. Bai, Alejandra C. Cherñavsky*

T1274

Dominant Mucosa-Associated Microbiota in Celiac Children At Diagnosis and After GFD Valerio Iebba*, Maria Pia Conte, Maria Barbato, Serena Schippa, Osvaldo Borrelli, Catia Longhi, Giulia Maiella, Valentina Totino, Franca Viola, Salvatore Cucchiara

T1275

The Presence of Intestinal Intra-Epithelial Gamma/Delta T-Lymphocytes Is Inversely Correlated with Lymphoma Development in Refractory Celiac Disease Wieke H. Verbeek*, B. Mary E. von Blomberg, Petra E. Scholten, Chris J. Mulder, Marco W. Schreurs

T1276

Loss of Memory B Cell Subsets in Uncomplicated Adult Coeliac Disease Alan Steel*, Sally-Ann Clark, Melanie Hart, Don Henderson, Frances Gotch, Brian Gazzard, Peter Kelleher

T1277

The Mechanisms Involved in Celiac-Like Lesions Induced By Mycophenolate Mofetil (MMF) Paul L. Beck*, Gary R. Martin, Yan Li, Josee F. Wong, Stefan J. Urbanski

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

MUCOSAL LYMPHOCYTE FUNCTION AND REGULATION Participants will be able to: • Learn more about the basic aspects of mucosal lymphocyte function and regulation. T1260

T1261

T1262

T1263

T1264

T1265

T1266



P-250

Regulatory T Cell-Based Cellular Therapy Prevents Colitis in WASP-Deficient Mice Michel H. Maillard*, Elisa K. Boden, Deanna D. Nguyen, Scott B. Snapper Dietary Component, Curcumin, Modulates Dendritic Cells to Differentiate Naïve CD4+CD25- T Cells Into Intestine-Protective Regulatory T Cells Through Retinoic Acid (RA) Production Yingzi Cong*, Charles O. Elson Regulation of the Host CD4+ T Cell Response to CBIR1 Flagellin, An Immunodominant Antigen of the Microbiota Yingzi Cong*, Lennard W. Duck, Charles O. Elson Transient Breaks in the Epithelial Barrier Lead to Regulatory T Cell Generation and Resistance to TNBSColitis Induction Monica Boirivant*, Antonello Amendola, Alessia Butera, Massimo Sanchez, Lili Xu, Atsushi Kitani, Warren Strober, Ivan J. Fuss Helminths Interact with the Innate Immune System to Protect from Murine IBD Arthur Blum, Tommy Setiawan, Long Hang, Korynn Stoyanoff, Joseph F. Urban, David E. Elliott, Joel V. Weinstock* A Novel Near-Infrared (NIFR) Probe Reveals Lysosomal Protease Activity in Intestinal Dendritic Cells (DCS) By Intravital Microscopy Carmen Alonso Cotoner*, Seiji Arihiro, Bayasi Guleng, Sonal Gupta, Umar Mahmood, Hans-Christian Reinecker Role of Adipokines in Inflammatory Bowel Disease Raja Fayad*, Venkatesh Ponemone, Ali Keshavarzian, Marc I. Brand, Theodore J. Saclarides, Herand Abcarian, Giamila Fantuzzi

Sails Pavilion San Diego Convention Center

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL T1278



MEFV Gene Mutations and Inflammatory Bowel Disease: Is There Any Effect? Filiz Akyuz*, Fatih Besisik, Binnur Pinarbasi, Kadir Demir, Sabahattin Kaymakoglu, Sadakat Ozdil, Gungor Boztas, Zeynel A. Mungan, Ahmet Gul

T1279

Association Between DNA Variants in the MDR1 Gene and Ulcerative Colitis in North Indians Vandana Midha*, Devendra K. Amre, Garima Juyal, Ernest G. Seidman, B. K. Thelma, Ajit Sood

T1280

A Combined Analysis of Genome-Wide Scans for Sarcoidosis and Crohn Disease Identifies a Common Susceptibility Locus Andre Franke*, Annegret Fischer, Andreas Till, Timothy T. Lu, Christian Becker, Joachim Müller-Quernheim, Michael Wittig, Alexander Herrmann, Tobias C. Balschun, Sylvia Hofmann, Peter Nürnberg, Jochen Hampe, Michael Krawczak, Manfred Schürmann, Philip C. Rosenstiel, Almut Nebel, Stefan Schreiber

T1281

Unexplained Recurrent Abdominal Pain Attacks in Carriers of the Thr309lys Mutation of Coagulation Factor XII Georg Dewald

T1282

Characterization of African Americans with Crohn's Disease: Dispelling the Myths Suhal S. Mahid*, Ryan D. Gholson, Daniel Roberts, Aaron M. Mulhall, Motaz Qadan, Susan Galandiuk

T1283

Association Between the Pregnane-X Receptor Gene and Crohn's Disease Among Children. Results from a GeneWide Case-Control and Family-Based Study Devendra K. Amre*, David R. Mack, David M. Israel, Kenneth Morgan, Alfreda Krupoves, Irina C. Costea, Philippe Lambrette, Colette Deslandres, Guy Grimard, Emile Levy, Ernest G. Seidman

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

T1288

Aspirin (ASA) and Its Nitric Oxide (NO) Derivative in the Healing of Colonic Damage in Experimental Model of Ulcerative Colitis Zbigniew Sliwowski*, Tomasz Brzozowski, Malgorzta Wcislo-Zwolinska, Peter C. Konturek, Robert Pajdo, Slawomir Kwiecien, Grazyna Biesiada, Stanislaw J. Konturek, Wieslaw W. Pawlik

T1289

Oral Porcine Plasma Proteins Prevent the Release of Mucosal Pro-Inflammatory Cytokines in Rats Challenged with S. Aureus Enterotoxin B Miquel Moretó*, Lluïsa Miró, Javier Polo, Louis Russell, Joy Campbell, Eric Weaver, Joe D. Crenshaw, Anna PérezBosque

T1290

Role of Adiponectin in Radiation-Induced Gastrointestinal and Hematopoietic Damage Venkatesh Ponemone*, Raja Fayad, Lawrence Chan, Giamila Fantuzzi

T1291

Enhanced Bone Marrow Contribution to Colonic Regeneration in Radiation Colitis Kazuko Shichijo*, Shiro Miura, Mutsumi M. Matsuyama, Masahiro Nakashima, Toshiyuki Nakayama, Ichiro Sekine

T1292

Glucagon-Like Peptide-2 Protects Against Abdominopelvic Radiation-Induced Intestinal and Colonic Damage Mustafa Deniz*, Güray Can, Beste M. Atasoy, Faysal Dane, Can Erzik, Sule Cetinel, Berrak C. Yegen

T1293

Anandamide Attenuates TNBS Colitis in AKR Mice: Importance of Endocannabinoid System in the Pathogenesis of Colitis Matthias A. Engel*, Carla Kellermann, Tilman Rau, Gregor Burnat, Eckhart G. Hahn, Peter Konturek

T1294

Severe Immunosuppressant Induced Ileal Crohn's Disease-Like Injury in Solid Organ Transplantation Recipients Treated with Mycophenolate Mofetil (MMF) Paul L. Beck*, Sapna Makhija, Gary R. Martin, Yan Li, Stefan J. Urbanski, Shaun A. Medlicott

T1295

Immuno-Modulatory Bovine Milk Bioactives to Improve Intestinal Health in Newborn Premature Piglets Hanne K. Moeller, Thomas Thymann, Anne S. Kvistgaard, Per T. Sangild*

T1296



Osteopontin Ablation Protects Against Progression of Acute and Chronic Stages of TNBS-Induced Colitis Helieh S. Oz*, Jian Zhong, Willem J. de Villiers

T1297

Dextran Sulphate Sodium Induced Colitis in Mice Induces Jejunal and Ileal Changes in Villus Height and Crypt Depth Potentially Regulated By Dipeptidyl Peptidase Activity Roger Yazbeck*, Suzanne Mashtoub, Catherine A. Abbott, Annika Wendland, Miranda Leach, Rachel Jennings, Hans Ulrich Demuth, Gordon S. Howarth

T1298



Comparison of the Effects of a COX-2 Selective Inhibitor (Firocoxib) and a Traditional NSAID (Flunixin Meglumine) On Recovery of Ischemic-Injured Equine Jejunum Vanessa Cook*, Colleen T. Meyer, Nigel Campbell, Jennifer Davis, Anthony T. Blikslager

T1299

Ischemia-Reperfusion Injury in Small Intestine Is Mediated By Toll-Like Receptor 2 Toshio Watanabe*, Tetsuya Tanigawa, Kazunari Tominaga, Kenji Watanabe, Yasuhiro Fujiwara, Nobuhide Oshitani, Koji Takeuchi, Tetsuo Arakawa

T1301

Acute Colonic Ischemia in Rats Is Associated to a Local, Long-Term, Infiltration of Mast Cells Without Alterations of Colonic Sensitivity Anna Ravnefjord, Erika Rehnström, Vicente Martinez*

Sponsored by: Intestinal Disorders

INTESTINAL INFLAMMATION, INJURY AND REPAIR II Participants will be able to: • Review recent research in intestinal inflammation, injury and repair. T1284



Anti-TNF Antibodies Do Not Ameliorate Bowel Injury in a Model of Acute Bowel Damage Induced By PAF and in a Neonatal Rat Model of Necrotizing Enterocolitis Shirley X. Liu, Runlan Tian, Isabelle G. De Plaen*

T1285

Interleukin-13 Induces Tissue Damage with Relocation of β-Catenin and Modification of Cell-Cell Adhesion in the Epithelial Cells Rei Kawashima*, Yuki I. Kawamura, Noriko Mizutani, Noriko Toyama-Sorimachi, Taeko Dohi



T1286

Prophylactic Effect of Irsogladine Maleate Against Indomethacin-Induced Small Intestinal Lesions in Rats: Mediation By cAMP Due to Inhibition of PDE4 Kikuko Amagase*, Kohei Kamei, Ryo Hatazawa, Naho Kato, Koji Takeuchi

T1287

The Tumor Suppressor Gene p53 Controls Innate Host Response and Development of Acute Intestinal Inflammation in Mice Young-Eun Joo*, Elisabeth Lippert, Christian Jobin

Denotes DDW Poster of Distinction

P-251

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y MAY 20

T1302

Development of a Mouse Model of Necrotizing Enterocolitis (NEC) Nikunj K. Chokshi*, Yigit S. Guner, Catherine J. Hunter, Anatoly V. Grishin, Henri R. Ford

AGA Institute Poster Session 8:00 AM - 5:00 PM

T1313

Combined Ciprofloxacin and Metronidazole Is Highly Effective for the Treatment of Pre-Pouch Ileitis Following Restorative Proctocolectomy Simon D. McLaughlin*, Andrew J. Bell, Sue K. Clark, Paris P. Tekkis, Paul J. Ciclitira, Ralph. J. Nicholls

T1314

The Inhibition Effect of Naringenin On Rat Conlonic Smooth Muscle Spontaneous Contractility and ICC Pacemaker Activity Zi-Huan Yang, Ao Pan, Siliang Chen, Jing-hui Guo, Wu-lin Zuo, Wen-liang Zhou*

T1315

Inhibitory Effect of Polaprezinc On Indomethacin -Induced Intestinal Epithelial Cell Injury Tatsushi Omatsu*, Yuji Naito, Osamu Handa, Natsuko Hayashi, Ikuhiro Hirata, Satoko Adachi, Tetsuya Okayama, Etsuko Kishimoto, Satomi Akagiri, Takahiro Suzuki, Katsura Mizushima, Tomohisa Takagi, Satoshi Kokura, Hiroshi Ichikawa, Toshikazu Yoshikawa

T1316

Correlation of Different Symptom Metrics to Severity of Illness Scale in the Evaluation of IBS Sian E. Bigora*, David Young, John Devane

Sails Pavilion San Diego Convention Center

Sponsored by: Intestinal Disorders

PHARMACOTHERAPY AND THE INTESTINE Participants will be able to: • Review recent research in pharmacotherapy and the intestine. T1303

Prevention of NSAID-Induced Small Intestinal Injury By Prostaglandin: A Pilot Randomized Controlled Trial Shunji Fujimori*, Tsuguhiko Seo, Katya Gudis, Atsushi Tatsuguchi, Akihito Ehara, Tsuyoshi Kobayashi, Keigo Mitsui, Shu Tanaka, Choitsu Sakamoto

T1304

Pharmacology of R-Verapamil: A Novel Therapy in IBS John Devane*, Mary Martin, John Kelly

T1317

T1305

A Novel Type of Therapeutic Potential in a Traditional Herbal Medicine Kakkonto Against Gastrointestinal Anaphylaxis By Reducing Mucosal Mast Cell-Surface Expression of FCεRi Yoko Suehiro*, Natsuko Kageyama, Makoto Kadowaki

Evaluating the Impact of Baseline Abdominal Pain/ Discomfort Scores On the Response to Rezular in IBS Sian E. Bigora*, David Young, John Devane

T1318

Incidence of Small Bowel Injury By Low-Dose EntericCoated Aspirin, and Efficacy of Misoprostol in Treating It - A Pilot Study with Capsule Endoscopy Toshio Watanabe*, Satoshi Sugimori, Natsuhiko Kameda, Hirotoshi Okazaki, Tetsuya Tanigawa, Kenji Watanabe, Kazunari Tominaga, Yasuhiro Fujiwara, Nobuhide Oshitani, Kazuhide Higuchi, Tetsuo Arakawa

T1319

Significance of Antibiotic Resistant Helicobacter pylori in a Chinese Population of Asia Kwong Ming Fock, Dhamodaran Subbiah, Eng Kiong Teo, Tiing Leong Ang, Jessica Tan, Kieron B. Lim*, David Ong

T1320

The Herbal Extract, Iberogast, Partially Improves Small Intestinal Integrity in Rats with Mucositis Induced By 5Fluorouracil Tessa H. Wright*, Ross N. Butler, Kerry A. Lymn, Roger Yazbeck, Ker Y. Cheah, Eleanor J. Whitford, Guy R. Sander, Gordon S. Howarth

T1321

An Extract from Grape Seed Protects IEC-6 Cells from Chemotherapy-Induced Cytotoxicity and Improves Parameters of Small Intestinal Mucositis in Rats with Experimentally-Induced Mucositis Ker Y. Cheah*, Susan E. Bastian, Ross N. Butler, Caroline Payne, Kerry A. Lymn, Roger Yazbeck, Tessa H. Wright, Eleanor J. Whitford, Guy R. Sander, Gordon S. Howarth

T1322

Safety and Tolerability of Prucalopride (Resolor®) in Patients with Chronic Constipation: Pooled Data from Three Pivotal Phase III Studies Jan F. Tack*, Jannie Ausma, Rene Kerstens, Lieve Vandeplassche

T1306

T1307

T1308

Thalidomide for Treatment of Chronic Gastrointestinal Bleeding from Angiodysplasias: A Pilot Study Patarapong Kamalaporn*, Ramasamy Saravanan, Maria Cirocco, Gary R. May, Gabor Kandel, Paul P. Kortan, Norman Marcon Treatment of Diarrhea-Predominant Irritable Bowel Syndrome with mesalazine and/or Saccharomyces Boulardii Mauro Bafutto*, Jose R. Almeida, Naylé V. Leite, Joffre Rezende Filho Comparison of the Effects of Acid Antisecretory Drugs On Cancer Chemotherapy-Induced Gastrointestinal Mucositis in Rats Yoichi Saegusa*, Kazuhiko Ishihara, Takafumi Ichikawa, Tomohisa Iwai, Yukinobu Goso, Katsunori Saigenji, Tomoaki Ikezawa

T1309

Evaluation of Interactions Between Morphine and Metoclopramide Din Ung, Hongbo Li, Alan Cowan, Henry P. Parkman*, Swati Nagar

T1310

Search for Prophylactic Drugs Against NSAID-Induced Small Intestinal Lesions in Rats Yukiko Yoda*, Koji Takeuchi, Shinichi Kato, Kikuko Amagase, Eiji Umegaki, Satoshi Tokioka, Kazuhide Higuchi

T1311

Gastrointestinal Tolerability of Anticholinergic Drugs for Treatment of Overactive Bladder Compared to Placebo: A Systematic Review and Meta-Analysis of 43 Studies Patrick D. Meek*, Samuel Evang, Mina Tadrous, Darren M. Triller

T1312

Constipation in Patients with Schizophrenia: A Systematic Review of Antipsychotic Trials Comparing Clozapine Patrick D. Meek*, Andrew D. Coates, Lisa Norelli, Daniel P. Woodcock, Oladayo Shobola, Stacy Dreyfus, Bora Gumustop, Beatrice Kovasznay

P-252

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL AGA Institute Poster Session 8:00 AM - 5:00 PM

T1332

Electroacupuncture Improves Impaired Gastric Accommodation and Vagal Activity in a Novel Rodent Model of Functional Dyspepsia Geng-Qing Song*, Yan Sun, Liansheng Liu, Pankaj J. Pasricha, Jiande Chen

T1333

Pathophysiologic Abnormalities in Patients with Unexplained Upper Gastrointestinal Symptoms: A Comparison of ROME III Subtypes vs. Patient Reported Dominant Symptom Carrie Chin-Garcia, Linda Anh B. Nguyen*, Amy J. Marincek, William J. Snape

Sails Pavilion San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility

GASTROPARESIS, FUNCTIONAL DYSPEPSIA AND OTHER GASTRODUODENAL DISORDERS Participants will be able to: • Review the role of new therapies in gastroparesis, functional dyspepsia and other gastroduodenal disorders.

T1334

Inflammation, Inducible Neuronal Nitric Oxide Synthase Expression and Loss of Neuronal Nitric Oxide Synthase in the Myenteric Plexus of Diabetes Prone BB Rats Are Independent of the Presence of Overt Diabetes Sebastien Kindt*, Pieter Vanden Berghe, Werend Boesmans, Jan F. Tack

T1335

Plasma Insulin, But Not Glucose, Inhibits Ghrelin Release in Vascularly Isolated Perfused Rat Stomach ExVivo; a Possible Mechanism of Increased Plasma Ghrelin Levels in Diabetes Hajime Ariga*, Kiyoshi Tsukamoto, Hiroshi Taniguchi, Christopher R. Mantyh, Theodore N. Pappas, Toku Takahashi

T1336

Cerebral Evoked Potentials During Visceral Stimulation in Non-Consulters with Functional Dyspepsia Jou Morishita*, Tomotaka Shoji, Yuka Endo, Yasuhiro Sagami, Satoshi Watanabe, Motoyori Kanazawa, Yuko Kimura, Tomomi Machida, Takatsugu Machida, Shin Fukudo, Michio Hongo

Prokinetic Effects of Electroacupuncture On Gastric Motility in Diabetic Rats Induced By Streptozotocin (STZ) Jieyun Yin*, Jiande Chen, Jie Chen

T1337

ROME III Subgroups of Functional Dyspepsia Exhibit Different Characteristics of Antral Strain Measured By Strain Rate Imaging Aymen Bushra Ahmed*, Knut Matre, Trygve Hausken, Hans Gregersen, Odd Helge Gilja

Local Release of Nitric Oxide Restores Gastric Emptying of Solid Food in STZ-Induced Diabetic Rats Mark S. Niedringhaus, Melissa A. Herman, Kenneth Dretchen, Robert R. Raulli, Richard A. Gillis, Niaz Sahibzada*

T1338

Gastric Slow Wave Dysrhythmias Underlying Gastroparesis in Mouse Models of Eating Disorders Andrea Lorincz*, Michael R. Bardsley, Laura Popko, Ferenc Izbéki, Tamas Ordog

T1339

A Stable Isotope Breath Test with a Standard Meal for Abnormal Gastric Emptying of Solids in the Clinic and in Research: Validation in 167 Subjects Lawrence A. Szarka*, Michael Camilleri, Adrian Vella, Duane D. Burton, Kari Baxter, Julie Simonson, Alan R. Zinsmeister

T1340

The Incidence, Prevalence and Survival of Gastroparesis in Olmsted County, Minnesota 1996-2006 Hye-kyung Jung*, Rok Seon Choung, G. Richard Locke, Cathy Schleck, Alan R. Zinsmeister, Lawrence A. Szarka, Brian Mullan, Nicholas J. Talley

T1341

Mild Hypovolemia Delays Liquid Gastric Emptying and Decreases Gastric Tonus in Humans Caio C. Freire, Érika B. Lima, Geraldo M. Macedo, Júlio M. Correia, Régis O. Nogueira, Marcellus H. Souza, Armênio A. Santos, Ricardo B. Oliveira, Miguel Souza*

T1342

Impaired Gastric Accommodation Due to Tropical Tripanosomiasis (Chagas' Disease) Miguel Souza*, Ricardo B. Oliveira, Tárcia N. Gomes, Maria Teresa G. Medeiros, Geraldo M. Macedo, Armênio A. Santos

T1343

A Clinical Outcome Analysis of Gastric Electrical Stimulation Therapy (Enterra) Beyond 5 Years for Severe Gastroparesis: A Single Center Experience Irene Sarosiek*, Katherine Roeser, Jameson Forster, Richard McCallum

T1344

Inflammation and Infection Leading to Hospitalizations for Exacerbations of Gastroparesis Sesha S. Uppalapati*, Zeeshan Ramzan, Robert S. Fisher, Henry P. Parkman

T1323

Do Different Types of Patients with Functional Dyspepsia in ROME III Criteria Vary in Related Pathophysiological Mechanisms? Zhiqiang Song*, Meiyun Ke, Zhifeng Wang, Xiucai Fang, Xiaohong Liu

T1324

Effect of Meal Volume and Caloric Load On Postprandial Gastric Function and Emptying Rate: Studies Under Physiological Conditions By Combined Magnetic Resonance Imaging (MRI) and Fiber Optic Pressure Sensor Monika A. Kwiatek*, Mark R. Fox, Dieter Menne, Andreas Steingoetter, Oliver Goetze, Elad Kaufman, Zsofia ForrasKaufman, Heiko Fruehauf, Peter Boesiger, Michael Fried, Werner Schwizer

T1325

T1326

T1327

T1328

T1329

T1330

T1331

Antral Inflammation and Electromechanical Dysfunction in Pediatric Dyspepsia Craig A. Friesen, Zhiyue Lin*, Meenal Singh, Vivekanand Singh, Jennifer Schurman, Nanci A. Burchell, Jose T. Cocjin, Richard McCallum Eating Disorders Among Patients Suffering from Functional Dyspepsia: Results of a ProspectiveControlled Study Isabelle Iwanicki-Caron*, Guillaume Gourcerol, Pierre M. Déchelotte, Philippe R. Ducrotte Oral Carbohydrate and Fat Differentially Modulate Symptoms, Gut Hormones and Antral Area in Functional Dyspepsia Amelia Pilichiewicz, Kate L. Feltrin, Michael Horowitz, Gerald J. Holtmann, Judith Wishart, Karen L. Jones, Nicholas J. Talley, Christine Feinle-Bisset* Correlation Between Plasma Ghrelin Levels and Gastric Emptying Time in Patients with Functional Dyspepsia and Non-Erosive Reflux Diseases Shindo Tomotaka*, Seiji Futagami, Tetsuro Hiratsuka, Masafumi Kusunoki, Nobue Ueki, Tatsuhiko Hamamoto, Katya Gudis, Kazumasa Miyake, Katsuhiko Iwakiri, Taku Tsukui, Choitsu Sakamoto Cellular Immune Activation Determines Symptom Severity in Patients with Functional Dyspepsia Tobias Liebregts*, Birgit Adam, Julia G. Junne, Montri Gururatsakul, Alexander Röth, Guido Gerken, Gerald J. Holtmann

Denotes DDW Poster of Distinction

P-253

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y MAY 20

T1345



The Pathological Basis of Gastroparesis Matthew S. Lurken*, Purna Kashyap, Henry P. Parkman, Thomas L. Abell, William L. Hasler, Kenneth L. Koch, Pankaj J. Pasricha, James Tonascia, Thomas C. Smyrk, Frank A. Hamilton, Gianrico Farrugia

T1346



Sensory and Autonomic Innervation of Gastric Smooth Muscle in Diabetic Patients with Gastroparesis Janelle Ryals, Irene Sarosiek, Richard McCallum, Douglas Wright*

T1347

A New Method to Quantify Interstitial Cells of Cajal in Gastroparesis Savio Reddymasu*, Thomas Champion, Irene Sarosiek, Scott D. Webster, Ivan Damjanov, Richard McCallum

T1348

T1349

T1350

T1351

INTERSTITIAL CELLS OF CAJAL AND SMOOTH MUSCLE Participants will be able to: • Evaluate the role of interstitial cells of cajal and smooth muscle.

Electroacupuncture Improves Impaired Gastric Myoelectrical and Motor Activities Induced By Rectal Distention in Dogs Jie Chen*, Geng-Qing Song, Jieyun Yin, Jiande Chen

T1360

Measurement of Gastric Slow Wave Parameters in Pigs from Simultaneous EGG/MGG During Health and Disease Andrei Irimia*, Leonard A. Bradshaw, William O. Richards



ICC-My Coordinate Longitudinal Muscle Behavior in Excised Loops and Isolated Segments of Mouse Ileum Grant W. Hennig*, Sari Jokela-Willis, Kenton M. Sanders, Terence K. Smith, Nicholas J. Spencer

T1362

Simple and Noninvasive Breath Test: Evaluation of Prokinetic Drugs On Gastric Emptying in the Conscious Rats Masayuki Uchida*, Kimiko Shimizu

Involvement of T-Type Calcium Channels in Initial Upstroke Potential in Slow Waves of Murine Small Intestine Kyung Sik Park*, Kenton M. Sanders, Sang D. Koh

T1363

Effects of Blood Glucose and Insulin On Interstitial Cells of Cajal in Diabetic Mice Colon Lin Lin*, Yurong Tang, Liming Xu, Li Xueliang, Hongjie Zhang, Wu Gaojue

T1364



The Effect of Stem Cell Factor On Interstitial Cells of Cajal in the Colon of Diabetic Mice Lin Lin*, Liming Xu, Yurong Tang, Hongjie Zhang, Li Xueliang, Wu Gaojue

T1365

Correlation Between the Interstitial Cells of Cajal and Electrophysiology in Patients with Gastrointestinal Motility Disorders Elizabeth Rickman*, Robert Schmieg, J. R. Salameh, Saleem Islam, William Johnson, Steve Bigler, Charu Subramony, Thomas L. Abell

T1366

Predictors of Gastric Emptying Using the Number of ICC Cells Compared with Electrophysiological Data from Patients with Gastrointestinal Motility Disorders Elizabeth Rickman*, Robert Schmieg, J. R. Salameh, Saleem Islam, William Johnson, Steve Bigler, Charu Subramony, Thomas L. Abell

T1367



Effect of Azithromycin On Antroduodenal Pressure Profiles of Patients with Gastrointestinal Dysmotility Payam Chini*, Baharak Moshiree, Wei Hou, Phillip P. Toskes

Differential Responses to Prostaglandins in the Circular and Longitudinal Muscle Layers of the Murine Small Intestine Joong Goo Kwon*, Fiona C. Britton, Kenton M. Sanders, Sean M. Ward

T1368

Acoustic Stress Attenuates Gastric Migrating Motor Complex, Without Affecting Motilin Release, Via Inhibiting Sympatho-Vagal Balance in Conscious Dogs Hitoshi Nakajima, Hiroshi Taniguchi, Kenji Imai, Hajime Ariga, Kirk A. Ludwig, Christopher R. Mantyh, Theodore N. Pappas, Toku Takahashi*

The Effect of Intestinal Smooth Muscle Tone On Morphometry and Residual Strain in Rat Duodenum, Jejunum and Ileum: A New Method to Evaluate SM Tone in Intestine Jiang Li*, Jingbo Zhao, Donghua Liao, Hans Gregersen

T1369

Role of PAR-2 in Enteric Nematode Infection-Induced Changes in Epithelial and Smooth Muscle Function Rex Sun*, Jennifer A. Stiltz, Aiping Zhao, Sarah NetzelArnett, Joseph F. Urban, Toni Antalis, Terez Shea-Donohue

T1370

Expression of Multi-Drug Resistance Protein 5 (MRP5), a cGMP Export Pump in Gastrointestinal Smooth Muscle Wimolpak Sriwai*, Karnam S. Murthy

Modulation of Individual Components of the Distal Gastric Motor Response to Duodenal Glucose Infusion in Healthy Humans Laura Bryant, Carly M. Burgstad*, Adam Deane, Marianne Chapman, Richard H. Holloway, Michael Horowitz, Robert Fraser

T1353

Magnetic Resonance Imaging of Dynamic Volume Change After a Meal: Inter-Observer Variability and Data Analysis Heiko Fruehauf*, Dieter Menne, Zsofia Forras-Kaufman, Elad Kaufman, Monika A. Kwiatek, Michael Fried, Werner Schwizer, Mark R. Fox

T1354

Utility of Antroduodenal Manometry Prior to Gastric Electrical Stimulation Jesse Liu*, Linda Anh B. Nguyen, Amy J. Marincek, Shelly Parker, William J. Snape

T1357

Predictive Model for the Cutaneous EGG Based On Internal and External Gastric Muscle Probes In Vivo Thomas L. Abell, Elizabeth Rickman*, William Johnson, Robert Schmieg, J. R. Salameh, Saleem Islam, Steve Bigler, Charu Subramony

T1358

Rapid Gastric Emptying Is Associated with Impaired Gastric Accommodation and Nausea in Patients with Chronic Upper Gastrointestinal Symptoms Robert M. Taylor*, Linda Anh B. Nguyen, William J. Snape

P-254

Sponsored by: Neurogastroenterology and Motility

Prostaglandin EP3 Receptor-Mediated Disruption of Gastric Slow Wave Rhythm and Coupling Measured By Multichannel Mucosal Mapping in An In Vivo Canine Model Radoslav Coleski*, William L. Hasler, Chung Owyang

Gastroparesis Hospitalizations in the US: Non-Diabetic Gastroparesis Is a Distinct and More Serious Health Problem Than Diabetic Gastroparesis Pankaj J. Pasricha, Ajitha Mannalithara, Alka Mithal, Amrita Sehgal, John M. Morton, Gurkirpal Singh*

T1356

Sails Pavilion San Diego Convention Center

T1359

T1352

T1355

AGA Institute Poster Session 8:00 AM - 5:00 PM

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL T1371

Down-Regulation of Caveolin-1 in Smooth Muscle from TNBS-Induced Colitis Mediates the Increase in Phosphodiesterase-5 Activity and Decrease in cGMPInduced Muscle Relaxation Sunila Mahavadi*, Wenhui Hu, Fang Li, Huiping Zhou, Hamid I. Akbarali, Karnam S. Murthy

T1383

Acotiamide Hydrochloride (Z-338), a Novel Gastroprokinetic Agent, Restores Delayed Gastric Emptying and Feeding Inhibition Induced By Restraint Stress in Rats Koichi Seto*, Takahiro Sasaki, Kokichi Katsunuma, Nobuyoshi Kobayashi, Koichiro Tanaka, Jan F. Tack

T1372

Modulation of Thin Filament Regulation of Contractile Mechanisms in Colonic Circular Smooth Muscle By HSP20 Sita Somara*, Robert R. Gilmont, Khalil N. Bitar

T1384

Effects of CP-464709, a Ghrelin Receptor Agonist, On Gastric Antral Motility and Gastric Emptying in Dogs Tohru Komada, Yasuo Ochi, Jeremy D. Gale*

T1373

Phospholamban Knockout Increases CaM Kinase II Activity, STOC Activity, and Alters Sodium Nitroprusside-Induced Relaxation of Murine Gastric Antrum Smooth Muscles Minkyung Kim*, Sang D. Koh, Brian A. Perrino

T1374

TRPV1 Mediated Attenuation of Carbachol-Induced Contraction in Mouse Antral Smooth Muscles Shaoyong Yu*, Qing Li, Ann Ouyang

T1375

Intestinal Chronic Obstruction Affects Motor Responsiveness of Rat Hypertrophic Longitudinal and Circular Muscles Simona Bertoni*, Paola Ghizzardi, Lisa Flammini, Francesca Saccani, Thomas Gobbetti, Fiore Cattaruzza, Mariannina Impicciatore, Vigilio Ballabeni, Elisabetta Barocelli



T1377

Failure of Myogenic Relaxation in Peristalsis: Phosphorylation Status of HSP20 Modulates Smooth Muscle Contraction/Relaxation By Regulating the Cytoskeleton and RHOA Robert R. Gilmont*, Sita Somara, Arti Dhiraaj, Khalil N. Bitar

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

T1385

Inhibitory Effect of Sildenafil On Duodenal Motor Activity in Mice Faiza Abdu*, Osama A. Abu-Zinadah

T1386

Effect of Small and Intermediate Conductance Potassium Channel Modulators On Visceral Hypersensitivity and Function Damian McHugh*, Victoria Head, Moh S. Panesar, Bruno Tigani, Alyson Fox, Elliot Lilley

T1387

SSR149415, a V1b Receptor Antagonist, Inhibits StressInduced Visceral Hypersensitivity in Rats Laurent Ferrier*, Eric Gaultier, Claudine Serradeil-Le Gal, Marc Pascal, Lionel Bueno

T1388

GTP-010 As a Therapeutic Tool in IBS Pain Relief: Prospective, Randomized, Placebo-Controlled Study of a GLP-1 Analog Per M. Hellström*, Jens Kristensen, Einar Bjornsson, Peter Bytzer, Jasper Hein, Hans Schambye

T1389

TD-5108, a Selective 5-HT4 Agonist, Is Consistently Better Than Placebo Regardless of Response Definition in Patients with Chronic Constipation Michael R. Goldberg*, Yu-Ping Li, Kenneth Pitzer, John F. Johanson, Allen W. Mangel, Michael M. Kitt

T1390

Rifaximin for the Treatment of Diarrhea-Associated Irritable Bowel Syndrome: Short Term Treatment Leading to Long Term Sustained Response Anthony Lembo*, Salam F. Zakko, Nelson L. Ferreira, Yehuda . Ringel, Enoch Bortey, Kecia Courtney, Ed Corsi, William P. Forbes, Mark Pimentel

T1391



The Effect of Neurokinin-1 Receptor Antagonism On Central Responses to Visceral Pain in Irritable Bowel Syndrome (IBS): A Pilot Study Kirsten Tillisch*, Joshua A. Bueller, Bruce D. Naliboff, Brandall Y. Suyenobu, Suzanne R. Smith, Roger E. Bolus, Emeran A. Mayer

T1392

Lack of Superiority of ST. John's Wort Over Placebo in Treating Irritable Bowel Syndrome (IBS): A Randomized Controlled Trial Yuri A. Saito*, Ann E. Almazar Elder, William S. Harmsen, Alan R. Zinsmeister, G. Richard Locke, Nicholas J. Talley

T1393

Fluvoxamine Versus Amitryptiline in Females with IBS and Depression Dan L. Dumitrascu*, Liliana David

T1394

Mesalazine Treatment for Intestinal Immune Activation in Patient with Irritable Bowel Syndrome: A Randomized Controlled Pilot Trial Giovanni Barbara*, Cesare Cremon, Luciana Gargano, Roberto De Giorgio, Rosanna Cogliandro, Vincenzo Stanghellini, Roberto Corinaldesi

T1395

Fermented Milk Containing the Probiotic Bifidobacterium Animalis, DN-173 010 (FM) Improves Abdominal Distension, Bloating and Transit in Irritable Bowel Syndrome with Constipation (IBS-C) Anurag Agrawal*, Lesley A. Houghton, Julie Morris, Denis Guyonnet, Nathalie Goupil Feuillerat, Armelle Schlumberger, Stefan Jakob, Peter J. Whorwell

Sponsored by: Neurogastroenterology and Motility

PHARMACOTHERAPEUTICS OF FUNCTIONAL GI AND MOTILITY DISORDERS POSTER SESSION Participants will be able to: • Learn about emerging pharmacological treatments of IBS. T1378

GLP-2 Treatment Protects Against Neuronal Loss and Enhances the Expression of VIP in the Submucosal Plexus in TNBS Colitis Laurie E. Wallace*, Keith A. Sharkey, David Sigalet

T1379

The Effect of Itopride Hydrochloride On the Intestinal Motility in Postoperative Ileus of Guinea Pig Hyojin Park*, Nu Ri Chon, Sang In Lee

T1380

Lubiprostone Enhances Histamine H2 Receptor-Mediated Cyclical Chloride Secretion in the Guinea Pig Colon Yu-Zhong Wang*, Helen J. Cooke, Laura M. Bohn, Ryuji Ueno, Jackie D. Wood

T1381

Inhibition of Colonic Motility and Defecation By RS127445 Suggests Involvement of the 5-HT2b Receptor in Large Bowel Physiology Gareth J. Sanger*, Anna K. Bassil, Victoria J. Bolton, Colleen M. Taylor, Karen Gray, Wendy J. Winchester, Kevin Lee

T1382

Therapeutic Potentials of Spinal Cord Stimulation for Gastrointestinal Motility Disorders: A Preliminary Rodent Study Geng-Qing Song*, Chao Qin, Yan Sun, Jiande Chen

Denotes DDW Poster of Distinction

P-255

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y

T1396

T1397

MAY 20

T1398

T1399

Randomized Controlled Trial of the Selective Serotonin Reuptake Inhibitor (SSRI) Citalopram (CIT) vs. Placebo (PLC) in Non-Depressed Patients with Irritable Bowel Syndrome (IBS) Uri Ladabaum*, Annie Sharabidze, Theodore R. Levin, Wei K. Zhao, Elaine H. Chung, Peter Bacchetti, Chengshi Jin, Barbara A. Grimes, Craig J. Pepin A Novel, Oral 5HT3 Partial Agonist, DDP733, Improves Overall Response in Patients with Irritable Bowel Syndrome and Constipation (IBS-c): A Randomized, Double Blind, Placebo-Controlled, Parallel-Group, DoseRanging Study William G. Paterson*, David Ford, Subhas C. Ganguli, Richard P. Reynolds, Lew Pliamm, Michael O'Mahony, Pierre Pare, Suhail Nurbhai, Brian Feagan, Steven B. Landau Gabapentin for Gastrointestinal Distress in Infants and Toddlers Ahmad M. Fraitekh, Jill S. Wolfson, Sharon M. Wolfson, John M. Belmont, Paul E. Hyman* In Patients with Chronic Constipation, TD-5108, a Selective 5-HT4 Agonist with High Intrinsic Activity, Relieves Straining and Bloating, Normalizes Stool Consistency and Reduces Laxative Use Michael R. Goldberg*, Yu-Ping Li, Allen W. Mangel, John F. Johanson, Kenneth Pitzer, Michael M. Kitt

T1400

Long-Term Follow-Up Study of Oral Prucalopride (Resolor®) Administered to Patients with Chronic Constipation Marc J. Van Outryve*, Greet Beyens, Rene Kerstens, Lieve Vandeplassche

T1401

Improving the Adequacy of the Adequate Relief Measure of Clinical Efficacy: A Bayesian and Conditional Probability Analysis of a Multicenter RCT for IBS Jeffrey M. Lackner*, James Jaccard, Allen W. Mangel, Bruce D. Naliboff

T1402

Efficacy of 12-Week Treatment with Prucalopride (Resolor®) in Patients with Chronic Constipation: Combined Results of Three Identical Randomized, Double-Blind, Placebo-Controlled Phase III Trials Michael Camilleri*, Renate Specht Gryp, Rene Kerstens, Lieve Vandeplassche

T1403

Involvement of Nk1 Mediated Mechanisms in the Control of Gastric Sensorimotor Function in Man Daphne C. Ang*, Rita Vos, Brecht Geeraerts, Filiz Akyuz, Jozef Janssens, Jan F. Tack

T1404

Mesalamine Alters Colonic Mucosal Proteolytic Activity and Fecal Bacterial Profiles in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Christopher N. Andrews*, Ruxandra Petcu, Tanya Griffiths, Jaime Bjarnason, Kevin Chapman, Laurie Cellars, Nathalie Vergnolle, Kevin P. Rioux

T1405

T1406

P-256

Effects of a Novel Corticotrophin Releasing Factor Receptor-1 Antagonist, BMS-562086, On Gastrointestinal and Colonic Transit and Bowel Habits in Patients with Diarrhea-Predominant Irritable Bowel Syndrome (D-IBS) Seth R. Sweetser*, Sara J. Linker Nord, Duane D. Burton, April Grudell, Deborah J. Eckert, Mhd Louai Manini, Irene Busciglio, Gary Tong, Randy C. Dockens, Alan R. Zinsmeister, Michael Camilleri Probiotic Bacteria Lactobacillus Acidophilus Ncfm and Bifidobacterium Lactis Bi-07 Improve Symptoms of Bloating in Patients with Functional Bowel Disorders (FBD). Yehuda . Ringel*, Olafur S. Palsson, Gregory Leyer, Sarah Causey, Sarah E. Yeskel, Steven M. Faber, Tamar RingelKulka

T1407

Efficacy of Pyloric Botulinum Toxin Injection and Pneumatic Balloon Dilation in Patients with Gastroparesis Refractory to Medical Treatment. a Retrospective Cohort Study William F. Marsteller*, Robert A. Oster, Alexandra Gutierrez

T1408

Cholinergic Antagonism Reverses Asynchrony Between the Circular and Longitudinal Muscle Contraction During Esophageal Peristalsis in Nutcracker Esophagus Patients Hariprasad R. Korsapati*, Valmik Bhargava, Ravinder K. Mittal

T1409

Effect of Electrical Acupuncture On Interdigestive Migrating Contractions and Plasma Motilin Levels in Normal Subjects Atsuto Nagoshi*, Motoyasu Kusano, Osamu Kawamura, Hiroko Hosaka, Masaki Maeda, Yasuyuki Shimoyama, Hiroaki Zai, Masatomo Mori

T1410

Reversal of Colonic Hypersensitivity By a Novel TRPV1Receptor Antagonist (JNJ-17203212) Karl R. Tyler*, Kristen M. Campbell-Dittmeyer, Sandra R. Chaplan, Alan D. Wickenden, Beverley Greenwood-Van Meerveld

T1411

Predictors of Clinical Response from a Phase 2 MultiCenter Efficacy Trial Using Rifaximin, a Gut-Selective, Nonabsorbed Antibiotic for the Treatment of DiarrheaAssociated Irritable Bowel Syndrome Yehuda . Ringel*, Salam F. Zakko, Nelson L. Ferreira, Enoch Bortey, Tina Wu, Kecia Courtney, William P. Forbes, Anthony Lembo, Mark Pimentel

T1412

Bupivicaine Vs Bupivicaine and Triamcinolone for Focal Abdominal Wall Pain- A UK Tertiary Referral Experience Neil Rajoriya*, San C. Kong, Fat W. Poon, John F. MacKenzie

T1413

The Addition of Pyloroplasty Is a New Surgical Approach That Enhances the Clinical Outcome to Gastric Electrical Stimulation (Enterra) in Patients with Post-Vagotomy Gastroparesis Compared to Diabetic/ Idiopathic Gastroparesis Irene Sarosiek*, Jameson Forster, Jerzy Sarosiek, Katherine Roeser, Richard McCallum

T1414

Effects of Mosapride Citrate, a 5-HT4 Receptor Agonist, On Rectosigmoid Motor and Sensory Function in Patients with Irritable Bowel Syndrome Motoyori Kanazawa*, Satoshi Watanabe, Chie Tana, Shin Fukudo

T1415

Dose-Related Study of the Effects of Solabegron On Gastrointestinal and Colonic Transit in Healthy Volunteers April Grudell*, Michael Camilleri, Kim L. Jensen, Amy E. Foxx-Orenstein, Michael D. Ryks, Kari Baxter, Duane D. Burton, George E. Dukes, Dennis L. Kelleher, Alan R. Zinsmeister

T1416

Influence of the 5-HT1A Agonist Buspirone On Rectal Tone and On the Perception of Rectal Distension in IBS with Rectal Urgency Sebastien Kindt*, Rita Vos, Jozef Janssens, Jan F. Tack

T1417

Neuro-Gastric Interactions: Transcutaneous Electrical Nerve Stimulation (TENS) On GI Acupoints Improved Gastric Myoelectrical Activity, Pain Scores, VIP and IL-6 Levels in Scleroderma Patients Hanaa Sallam, Terry McNearney, Dipti Doshi, Sonya E. Hunnicutt, Jiande Chen*

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL T1418

Cardiovascular Safety of Prucalopride (Resolor®) in Healthy Subjects: Results from a Randomized, DoubleBlind, Placebo-Controlled, Cross-Over Trial Malcolm J. Boyce*, William Carey, Erik J. Mannaert, Annemie Mertens, Jannie Ausma

T1429



Protease Activated Receptor 2 Sensitizes Transient Receptor Potential Vanilloid 4 On Mouse Colonic Dorsal Root Ganglia Neurons Francisco Bautista-Cruz*, Nigel W. Bunnett, Stephen J. Vanner

T1419

Improvement of Meal-Induced Gastric Compliance and Gastric Emptying in Patients with Functional Dyspepsia By Treatment with Rikkunshito (Liu-Jin-Zi-Tang: Traditional Chinese Herbal Medicine).—Real-Time Ultrasonographic Study— Hiroaki Kusunoki*, Jiro Hata, Ken Haruma, Manabu Ishii, Motonori Sato, Yoshiyuki Yamanaka, Minoru Fujita, Kenichi Tarumi, Hiroshi Imamura, Noriaki Manabe, Tomoari Kamada, Akiko Shiotani

T1430

Sustained Hyperexcitability of Nociceptive DRG Neurons Following Inflammation in a Citrobacter rodentium Model of Post- Infectious Irritable Bowel Syndrome (IBS): A Role for IA K+ Currents Charles Ibeakanma*, Francisco Bautista-Cruz, Michele Richards, David J. Hurlbut, Nancy Martin, Stephen J. Vanner

T1420

T1421

T1422



T1423

Effect of Bifidogenic Growth Stimulator On Patients with Constipation-Predominant Irritable Bowel Syndrome Tomofumi Amano*, Hajime Ariga, Shigeru Yamato Influence of Itopride On Gastrointestinal Motility in Dyspeptic Patients.—Real-Time Ultrasonographic Study— Hiroaki Kusunoki*, Ken Haruma, Jiro Hata, Manabu Ishii, Motonori Sato, Toshiaki Tanaka, Kayoko Shimizu, Minoru Fujita, Ken-ichi Tarumi, Hiroshi Imamura, Noriaki Manabe, Akiko Shiotani Sex Differences in Regional Functional Brain Activation Elicited By Colorectal Distention in Conscious, NonRestrained Rats Yumei Guo, Zhuo Wang, Sylvie Bradesi, Jean-Michel I. Maarek, Kevin Lee, Wendy J. Winchester, Emeran A. Mayer, Daniel P. Holschneider* Assessment of Colonic Secretory Function and Faecal Output in Viscerally Hypersensitive Wistar Kyoto Rats Niall P. Hyland*, Sinead M. Gibney, Romain D. Gosselin, Kevin Lee, Timothy G. Dinan, John F. Cryan

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

T1431

The NO Pathway in Gastroesophageal Vagal Afferent Endings Amanda J. Page*, Tracey A. O'Donnell, Nicole J. Cooper, Richard L. Young, L. Ashley Blackshaw

T1432

Colitis-Induced Bladder Overactivity Is Mediated By a Primary Afferent Pathway Li-Ya Qiao*, Melisa Gulick, John R. Grider

T1433

Effect of Estrogen On Visceral Sensory Function in a Non-Inflammatory Colonic Hypersensitivity Rat Model Magali Krayer*, Christian Knusel, Mareike Oulevey, Beatrice Flogerzi, Luis A. Tovar, Bruno M. Balsiger, Manfred Essig, Ulrich Scheurer, Juergen M. Gschossmann

T1434

Sex Differences in the Characteristics and Role of the Postsynaptic Dorsal Column (PSDC) Pathway in Visceral Pain Jing Wang, Chunping Gu, Elie D. Al-Chaer*

T1435

Endogennous Oxidative Stress Products That Are TRPA1 Receptor Agonists Stimulate Nociceptors in the Esophagus Mariana Brozmanova, Fei Ru, Thomas E. Taylor-Clark, Marian Kollarik*

T1436

Artemin Overexpression Modulates Extrinsic Esophageal Sensory Innervation Fang Zhong, Kathryn M. Albers, Klaus Bielefeldt*

T1437

TPRV1 Is Selectively Expressed in a Functionally Distinct Subset of Colonic Afferents Sacha Malin, Julie A. Christianson, Klaus Bielefeldt*, Brian M. Davis

T1438

Endosomal Endothelin Converting Enzyme-1 (ECE-1) Controls Resensitization the Proinflammatory and Nociceptive Effects of Substance P (SP) and Calcitonin Gene-Related Peptide (CGRP) Fiore Cattaruzza*, Graeme S. Cottrell, Benjamin E. Padilla, Nigel W. Bunnett

T1439

Reactive Prostaglandins (PG) Activate Transient Receptor Potential (TRP) A1 On Nociceptive Neurons to Induce Pain Eunice Andre, Serena Materazzi, Romina Nassini, Silvia Amadesi, Riccardo Patacchini, Pierangelo Geppetti, Nigel W. Bunnett*

T1440

Anxiety Induction Is Associated with Greater AcidInduced Esophageal Pain Hypersensitivity Abhishek Sharma*, Lukas Van Oudenhove, Peter Paine, Qasim Aziz

T1441

Autonomic Nervous System Responses to Esophageal Acidification Predict Inter-Individual Variability in the Magnitude of Sensitization Abhishek Sharma*, Peter Paine, Qasim Aziz

T1442

Tissue Specific Knockdown of NMDA Receptors in Primary Afferent Neurons Decreases Inflammatory Hyperalgesia James A. McRoberts*, Helena S. Ennes, Bryce Vissel, Michael S. Fanselow, Emeran A. Mayer

Sponsored by: Neurogastroenterology and Motility

VISCEROSENSORY MECHANISMS AND VISCERAL NOCICEPTION POSTER SESSION Participants will be able to: • Evaluate recent research in viscerosensory mechanisms and visceral nociception. T1424



Activation Profile of the Spinal Nociceptive Afferent Neurons Innervating the Guinea Pig Esophagus Fei Ru*, Mariana Brozmanova, Marian Kollarik

T1425

Reciprocal Changes in Vanilloid (TRPV1) and Endocannabinoid (CB1) Receptors Contribute to Visceral Hyperalgesia in the Water Avoidance Stressed Rat Shuangsong Hong*, Jing Fan, Elyse S. Kemmerer, Ying Li, John W. Wiley

T1426

T1427

T1428

Delayed Post-Inflammatory Hypersensitivity in SubPopulations of Colonic Afferents Patrick A. Hughes*, Stuart M. Brierley, L. Ashley Blackshaw Sensitization of Visceral Afferents By Immune Cell Supernatants from IBS Patients Patrick A. Hughes*, Stuart M. Brierley, Tobias Liebregts, Birgit Adam, Gerald J. Holtmann, L. Ashley Blackshaw T-Cell Regulation of Jejunal Afferent Hypersensitivity in Nematode Infected Mice Christopher D. Keating*, Adrian Smith, David Grundy

Denotes DDW Poster of Distinction

P-257

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y

T1443

Mechanoreceptors Innervating the External Anal Sphincter of the Guinea Pig Penny Lynn*, Marcello Costa, Simon Brookes

T1444

T1445

MAY 20 T1446

T1447

T1448

T1456

Dose Response Evaluation and Reliability of the Oral Capsaicin Capsule Test in Healthy Subjects Martina Führer*, Johann Hammer

Histamine and Serotonin Sensitizes the Transient Receptor Potential Vanilloid Receptor 4 to Induce Visceral Allodynia and Hyperalgesia Nicolas Cenac*, Christophe Altier, Zamponi Gerald, Nathalie Vergnolle

T1457

Is Visceral Hypersensitivity in Irritable Bowel Syndrome Due to Sensitisation of Pain-Selective or Multimodal Afferent Pathways? Jenny Gunnarsson*, Iris Posserud, Jan F. Tack, Hasse Abrahamsson, Magnus Simren

Evidence for Esophageal Mechanical Hypersensitivity with Aberrant Viscerosomatic Referral in Patients with Globus Chien-Lin Chen*, Michal M. Szczesniak, Taher Omari, Ian J. Cook

T1458



Sex-Dependent Differences in Nociceptive Responses to Peripheral NMDA Receptor Activation Helena S. Ennes*, Brian Nguyen, Emeran A. Mayer, James A. McRoberts

T1459

Swallow Induces a Peristaltic Wave of Inhibition That Marches in Front of the Peristaltic Wave of Contraction Along the Length of the Esophagus in Normal Subjects Luiz J. Abrahao*, Valmik Bhargava, Arash Babaei, Andrew Ho, Ravinder K. Mittal

T1460

A Pro-Nociceptive Role for Hydrogen Sulfide in Irritable Bowel Syndrome Guang-Yin Xu*, Mohan Shenoy, John Winston, MariaAdelaide Micci, Pankaj J. Pasricha

T1461

Genetic Deletion of P2X3 Receptor Blunts Gastroesophageal Mechanosensation Klaus Bielefeldt*, Brian M. Davis

T1462

Central Sensitization - Induction of Both Rectal Hypersensitivity and Activation of the Diffuse Noxious Ihibitory Control (DNIC) Following Acid and Capsaicin Infusion in the Human Esophagus Trine Andresen*, Christina Brock, Jens Brøndum Frøkjær, Jeremy D. Gale, Asbjørn M. Drewes

T1463

Primary Afferent Neurons Innervating the Adult Mouse Small and Large Intestines Are Mostly Medium-Sized and Are Marked By TRPV1, NOS, SP and CGRP Linette L. Tan, Joel C. Bornstein*, Colin R. Anderson

T1464

Activation of ERK in Sensory Neurons After Noxious Gastric Distension and Its Involvement in Acute Visceral Pain in Rat Jun Sakurai*, Koichi Obata, Takashi Kondo, Tadayuki Oshima, Toshihiko Tomita, Takayuki Matsumoto, Koichi Noguchi, Hiroto Miwa

T1465

Indomethacin-Induced Inflammation in the Mouse Jejunum Is Accompanied By An Inducible Nitric Oxide Synthase (iNOS) Dependent Attenuation of Afferent Nerve Sensitivity Bing Xue*, Mario H. Mueller, Mia Karpitschka, Andrej Sibaev, Martin E. Kreis

T1466

The Neurophysiology of Gastric Sensation in Health: A Role for Cortical Deactivations? Lukas Van Oudenhove*, Patrick Dupont, Joris U. Vandenberghe, Brecht Geeraerts, Guy Bormans, Koen Van Laere, Rita Vos, Koen Demyttenaere, Jan F. Tack

T1467

Visceral and Somatic Sensitivity in Patients with Irritable Bowel Syndrome and Coeliac Sprue Maria Pia Caldarella, Gianpia Affaitati, Mariaelena Serio, Alessandra Fabrizio, Chrysanthi Balatsinou, Antonella Savini, Angelo Milano, Francesco Laterza, Maria Adele Giamberardino, Matteo Neri*

T1468

Stimulation of the Medial Thalamus-Anterior Cingulate Cortex Synapses Is Important for Learning and Triggering Pain Memories in Visceral Hypersensitive States Xiaoyin Wu, Jing Fan, Zhijun Cao, Shenliang Chen, Rui Zhang, Min Wang, Chung Owyang, Ying Li*

The Transient Receptor Potential Vanilloid Type 1 (TRPV1) Receptor Antagonist BCTC Attenuates ColitisInduced Sensitization of Pelvic Afferent C-Fibers in Anaesthetized Rats Heiko U. De Schepper*, Benedicte Y. De Winter, Arnold G. Herman, Paul A. Pelckmans, Joris G. De Man Gamma Oscillation Reflect the Dysfunctional Visceral Sensory Processing and Modulation in Irritable Bowel Syncrome Satoshi Watanabe*, Tomomi Hattori, Motoyori Kanazawa, Michiko Kano, Shin Fukudo Convergent Neural Pathways Exist Between the Stomach and Pancreas and Can Be Activated By Intragastric Alcohol: Implications for Pancreatic Inflammation and Pain Liansheng Liu, Auzhand Y. Zonozy, Gabriel H. Lee, Mohan Shenoy, Amanpal Singh, John Winston*, Pankaj J. Pasricha

T1449

TNBS Colitis Evokes Hyperalgesic Priming of Mouse Colonic Dorsal Root Ganglia Nociceptive Neurons Involving a PKC Mechanism Fernando Ochoa-Cortes*, Francisco Bautista-Cruz, Ian Spreadbury, Stephen J. Vanner

T1450

Glucocorticoids Mediate Spinal Microglia Activation and Visceral Hyperalgesia in a Rat Model of Chronic Stress Sylvie Bradesi*, Camilla I. Svensson, Charalabos Pothoulakis, Tony L. Yaksh, Emeran A. Mayer

T1451

Oral Pregabalin Inhibits Visceral Pain Responses to Colorectal Distension and Increases Colonic Compliance in Rats Anna Ravnefjord, Mikael Brusberg, Håkan Larsson, Erik Lindström, Vicente Martinez*

T1452

Predicting the Magnitude of Endogenous Visceral Pain Modulation Using Simple Noxious Visceral or Somatic Stimulation Clive H. Wilder-Smith*, Guang Hui Song, Khay Guan Yeoh, Khek Yu Ho

T1453

Differential Effects of Acute TNBS Colitis On the Expression of Voltage-Gated Na+ Channels in Convergent and Non-Convergent Dorsal Root Ganglion Neurons Anna Malykhina

T1454

T1455

P-258

Intracolonic Infusion of Fecal Supernatants from Diarrhea-Predominant Irritable Bowel Syndrome Patients (IBS-D) Evokes Visceral Hyperalgesia in Mice: Reversal By a Probiotic Treatment Via a Decrease of Luminal Serine-Protease Activity Afifa Ait-Belgnaoui*, Helene Eutamene, Laurent Ferrier, Henri Durand, Jean Fioramonti, Lionel Bueno, Vassilia Theodorou Fundus Ligation in Adolescent Rats Chronically Alters the Responses of Vagal Mechanosensitive Afferents Innervating the Stomach and Results in Expansion of Receptive Field Adrian Miranda*, Aaron D. Mickle, Jamie Schmidt, Banani Banerjee, Bidyut K. Medda, Reza Shaker, Jyoti N. Sengupta

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL T1469

Diffuse Noxious Inhibitory Controls (DNIC) Are Compromised in Patients with Irritable Bowel Syndrome Compared to Healthy Controls Steve Heymen*, William Maixner, William E. Whitehead, Rebecca R. Klatzkin, Beth Mechlin, Kathleen C. Light

T1470

Rectal Distension Produces Reductions in Celiac and Superior Mesenteric Artery Blood Flow in Anesthetized Rats - a Novel Observation Felix W. Leung

Denotes DDW Poster of Distinction

T U E S D A Y MAY 20

P-259

POSTER SESSIONS—COMBINED T U E S D A Y MAY 20

COMBINED AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Nutrition & Obesity

ENTERAL AND PARENTERAL NUTRITION Participants will be able to: • Evaluate recent research on enteral and parenteral nutrition. T1471

Incidence of Complications Associated with Chronic Home Parenteral Nutrition Is Higher in Patients with a Motility Disorder Than Short Bowel Syndrome As Their Underlying Disease John K. Siepler*, Thomas G. Diamantidis, Reid A. Nishikawa, Rod J. Okamoto

T1472

Feeding Tube Preferences and Knowledge of Published Literature of Intensive Care Unit Physicians a Single Center Experience At the Johns Hopkins Hospital Ghazaleh Aram*, Kerry B. Dunbar, Francis M. Giardiello, John H. Kwon

T1474

Percutaneous Endoscopic Gastrostomy (PEG) Insertion Rate Is Falling But Early Mortality Remains High Reshma C. Rakshit*, Jeremy M. Nightingale

T1475



Early Enteral Nutrition Improves Functional Parameters in Liver Cirrhosis Kristina Norman*, Christine Smoliner, Nicole Stobaeus, Tatjana Schuetz, Herbert Lochs, Johann Ockenga, Matthias Pirlich

T1476

The Rate of Post-Hospital Bloodstream Infection in Patients Requiring Home Parenteral Nutrition Is High and Is Related to Pre-Discharge Blood Glucose Control Vivian M. Zhao*, Daniel P. Griffith, Nisha J. Dave, Cynthia H. Battey, Therese A. McNally, Kirk A. Easley, Henry M. Blumberg, John R. Galloway, Thomas R. Ziegler

P-260

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL CLINICAL ASGE Poster Session 8:00 AM - 5:00 PM

T1490

Minor Endoscopic Sphincterotomy Plus Endoscopic Balloon Dilation Is An Effective and Safer Alternative for Endoscopic Sphincterotomy During ERCP in Patients with Peiampullary Diverticula and Bile Duct Stones Feng Liu*, Feng Li, Ying Zhou, Meijuan Xi, Duowu Zou, Zhaoshen Li

Sails Pavilion San Diego Convention Center

ERCP BILIARY-PANCREAS T1479

Diagnosis of Intraductal Papillary-Mucinous Neoplasm of the Pancreas By Using Peroral Pancreatoscopy (POPS)- the Usefulness of Pops with Narrow -Band Imaging (NBI) Taro Hara*, Taketo Yamaguchi, Kentaro Sudo, Kazuyoshi Nakamura, Tadamichi Denda, Takeshi Ishihara

T1491

Is Therapeutic Endoscopic Retrograde Cholangiopancreatography Safe and Effective During Live Demonstrations?-A Large Multi-Center Study from China Zhuan Liao, Zhao-Shen Li*, Joseph W. Leung, Feng Li, William Chao

T1480

Intraluminal Implantation of Radioactive Stents for Treatment of Unresectable Pancreatic Cancer, Extrahepatic Bile Duct Carcinoma and Ampullary Carcinoma: A Pilot Trial Yan Liu*, Zheng Lu

T1492

Can MRCP Replace ERCP for the Diagnosis of Autoimmune Pancreatitis? Terumi Kamisawa*, Naoto Egawa, Kouji Tsuruta, Atsutake Okamoto

T1481

Cholangiopancreatoscopy (CP) and EUS for Suspected Pancreaticobiliary Neoplasms (PBN) Abdul H. Khan*, Yang K. Chen, Gregory L. Austin, Amrita Sethi, Brian C. Brauer, Krishnavel V. Chathadi, Norio Fukami, Raj J. Shah

T1493

Mechanical Simulator Practice Speeds Up Selective Cannulation Time of Novice Trainees in “Standard” But Not “Distorted” Simulator Settings Joseph W. Leung, Brian S. Lim*, Robert E. Wilson, WeiChih Liao, Jaw-Town Lin, Zhao-Shen Li, Khean-Lee Goh, Felix W. Leung

T1482

The Financial and Clinical Implications of Failure At ERCP Shyam Varadarajulu*, Jessica Trevino, Charles M. Wilcox

T1494

T1483

Intraductal Ultrasound Improves Diagnostic Yield for ERCP and Cytology Brushing in Detecting Malignant Bile Duct Strictures for Patients Without Biliary Mass Lesions On CT or MRI Feng Liu*, Feng Li, Ying Zhou, Duowu Zou, Zhaoshen Li

The Effect of Sildenafil On Sphincter of Oddi Pressure in Patients Undergoing ERCP for Suspected Sphincter of Oddi Dysfunction Kevin C. Ruff*, Stuart L. Triester, Michael D. Crowell, M. Edwyn Harrison

T1495

Evaluation of a New, Mechanical ERCP Simulator Joe Healy*, James Kimberly, John Baillie, Stan Remiszewski, Jeffrey Radziunas, Ronald L. Green, Barbara Wilkes

T1484

Utility of Peroral Cholangioscope (Spy Glass System) in Treatment of Stones in Chronic Pancreatitis Nalini M. Guda*, Joseph E. Geenen, Marc F. Catalano

T1496

A UK National Survey Into Safety Awareness and Practice in Diagnostic and Therapeutic ERCP Neil Rajoriya*, Anthony S. Mee

T1485

SPYGLASS: Experience with a New Mini-Endoscope in Bilio-Pancreatic Disease Isaac Raijman*, Douglas S. Fishman, Paul R. Tarnasky, Sandeep Patel

T1497

SPYGLASS: Experience with a New Choledochoscope in the Management of Difficult Bile Duct Stones Isaac Raijman*, Douglas S. Fishman, Paul R. Tarnasky, Sandeep Patel

T1486

Overtube Balloon Assisted Direct Peroral Cholangioscopy Using An Ultra-Slim Upper Endoscope: A Feasibility Study Hyun Jong Choi*, Jong Ho Moon, Bong Min Ko, Su Jin Hong, Hyun Cheol Koo, Young Koog Cheon, Young Deok Cho, Joon Seong Lee, Moon Sung Lee, Chan Sup Shim

T1498

T1487

The Usefulness of Therapeutic Small Bowel Balloon Endoscopy in Biliopancreato Diseases Kentaro Ishii*, Takao Itoi, Atsushi Sofuni, Fumihide Itokawa, Toshio Kurihara, Shujiro Tsuji, Nobuhito Ikeuchi, Fuminori Moriyasu

A Multi-Site, Single ARM, Prospective Study of a New Nitinol, Self-Expanding, Biliary Fully-Covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction Bret T. Petersen*, Michel Kahaleh, Richard A. Kozarek, David E. Loren, Kapil Gupta, Thomas E. Kowalski, Martin L. Freeman, Yang K. Chen, Malcolm S. Branch, Steven A. Edmundowicz, Kenneth F. Binmoeller, Todd H. Baron, Michael Gluck, Kamran Ayub, Raj J. Shah, Timothy P. Kinney, William A. Ross, Paul S. Jowell

T1499

T1488

ERCP Tissue Sampling of Cholangiocarcinoma Presenting with Biliary Obstruction Permits IntraProcedural Diagnosis and Results in High Positive Yield Burr J. Loew, Douglas A. Howell*, Ramu Raju, Harsha Vittal, Michael K. Sanders, Kirk Bernadino, Michele B. Delenick, Lisa A. Rutstein, Hagen Blaszyk

Strategy for Differentiating Autoimmune Pancreatitis from Pancreatic Cancer Terumi Kamisawa*, Naoto Egawa, Kouji Tsuruta, Atsutake Okamoto

T1500

SPYGLASS Direct Visualization System Cholangiopancreatoscopy: Single Center Experience Rajesh N. Keswani*, Sreenivasa S. Jonnalagadda, Riad R. Azar, Esmat Z. Sadeddin, Steven A. Edmundowicz

T1501

Success Rate and Complications of ERCP Performed During Hands-On Training Courses: A Multicenter Study in China Zhuan Liao*, Zhao-Shen Li, Joseph W. Leung, Feng Li, William Chao

T1489

Clinical Applications of the SPYGLASS Direct Visualization System: A Multicenter Experience David Loren*, Thomas E. Kowalski, Mitchell Conn, Bheema Singu, Oleh Haluszka, Jeffrey L. Tokar, Eric Shen, Tamir Ben-Menachem

Denotes DDW Poster of Distinction

P-261

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y MAY 20

T1502

Double Balloon Enteroscopy (DBE)-Assisted ERCP Following Roux-en-Y Biliary Reconstruction: New Tool for An Old Problem Charles E. Dye*, Giuliano Testa, Irving Waxman, Andrew S. Ross

T1515

The Cost-Effectiveness of High-Dose Intravenous Proton Pump Inhibition Administered After Endoscopic Hemostasis Using Quality-Adjusted Life Years As Unit of Effectiveness Alan Barkun*, Viviane Adam

T1503

Pathologic Analysis of Covered Self-Expanding Metallic Stents After Pancreaticobiliary Extraction Steven L. Condron*, Andrew Y. Wang, Tanya D. Morris, Paul Yeaton

T1516

T1504

The Usefulness of Multibending Scope for Selective Cannulation During ERCP in Patient with a Billroth II Gastrectomy Hyun Cheol Koo*, Jong Ho Moon, Hyun Jong Choi, Bong Min Ko, Young Koog Cheon, Su Jin Hong, Young Deok Cho, Joon Seong Lee, Moon Sung Lee, Chan Sup Shim

Repeat Colonoscopy Guideline Adherence Following Screening and Surveillance Exams in a Community Gastroenterology Practice Scott W. Rathgaber*, Laura E. Black, Wendy Berth, Jacob Gundrum

T1517

Videocapsule Versus Push Enteroscopy in Patients with Obscure GI Bleeding: Planned Interim Analysis of An Outcomes RCT Alan Barkun*, Pascal C. Burtin, Josee Parent, Serge Mayrand, Carlo A. Fallone, Gilles Jobin, Valerie VillardBellier, Myriam Martel, Joyce Strazzulla, Kellee Durnin, Li Yingchun

T1518

Management of Gastrojejunal Anastomotic Stricture After Laparoscopic Roux-en-Y Gastric Bypass Wael Z. El Darawy*, Piotr Gorecki, Maurice A. Cerulli, Won Sohn

T1519

Complication Rate of Gastrointestinal Endoscopy Procedures At a Community Hospital Deepika Devuni*, Anthony Aghenta, Ann Rapson, Tarun Kothari

T1520

Propofol vs. Meperidine/Midazolam Sedation for Screening Colonoscopy: Improved Quality Indicators Alexander Lee

T1521

Outcomes Following Gastrostomy: Radiologically Inserted vs. Percutaneous Endoscopic Gastrostomy John S. Leeds*, Mark E. McAlindon, Julia Grant, Helen E. Robson, Stephen Morley, Fred K. Lee, David S. Sanders

T1522

Predicting Outcomes Following Gastrostomy Insertion Using the Sheffield Gastrostomy Score. A Prospectively Devised Scoring System with a Validation Cohort John S. Leeds*, Stephen Morley, Roger Marr, Helen E. Robson, Julia Grant, Fred K. Lee, Mark T. Donnelly, Mark E. McAlindon, David S. Sanders

T1523

Multi-Center Evaluation of a SPYGLASS System for Percutaneous Examination of the Biliary System Isaac Raijman*, Adam Slivka

ERCP-Related Perforations: Analysis of Patient-Outcome After ERCP in Over 2700 Patients Sumit Kapoor, Devi Mukkai Krishnamurty*, Frederick Eckhauser, Anthony N. Kalloo, Patrick Okolo, Sanjay B. Jagannath

T1524

Double Balloon Enteroscopy (DBE) Can Be Routinely Employed to Perform ERCP in Bariatric Gastric Bypass (RYGB) Patients Simon K. Lo*, Gauree Gupta, Richard A. Kozarek, Charles E. Dye, Ananya Das, Andrew S. Ross

Comprehensive Colonoscopy Quality in a Community Gastroenterology Practice Scott W. Rathgaber*, Laura E. Black, Jacob Gundrum, Wendy Berth, Michelle A. Mathiason

T1525

Endoscopic Balloon Dilatation to Treat Stricture Caused By Circumferential Resection of the Gastric Antrum By Endoscopic Submucosal Dissection Kotaro Mannen*, Seiji Tsunada, Shinichi Ogata, Seiichiro Arima, Yasuhisa Sakata, Ryosuke Shiraishi, Ryo Shimoda, Hibiki Ootani, Kanako Yamaguchi, Takehiro Fujise, Hiroyuki Sakata, Ryuichi Iwakiri, Kazuma Fujimoto

T1526 Cost-Effectiveness Analysis of MRCP, EUS and ERCP in Patients with Suspected Choledocolithiasis Eduardo B. da Silveira*, Alan Barkun

Does Type of Sedation Affect Cecal Intubation and Polyp Detection Rates? Leon M. Kogan*, Maurice A. Cerulli

T1527

Optimal Screening Intervals for Individuals with a Family History of Colorectal Cancer Janneke Wilschut, Monique E. van Leerdam, E. J. Kuipers*, E. W. Steyerberg, Marjolein van Ballegooijen

The Effect of the 2001 Change in State and National Colon Cancer Screening Policy At a Large Academic City Hospital On Colon Polyp and Cancer Detection Jeanette G. Smith*, Wenjie Li, Jeffry Nestler

T1528

Race and Gender Differences in Surveillance Participation After Polyp Detection On Initial Colonoscopy D. Eli Penn*, Donald A. Garrow, Joseph Romagnuolo

T1505

T1506

T1507

T1508

Can We Reduce the Radiation Exposure During ERCP Procedure By Using a Novel Protective Lead Shield? Toshio Kurihara*, Takao Itoi, Atsushi Sofuni, Fumihide Itokawa, Shujiro Tsuji, Kentarou Ishii, Nobuhito Ikeuchi, Fuminori Moriyasu Echogenicities in Intraductal Ultrasonography Are Real Biliary Microlithiasis? Pung Kang*, Jong Kyun Lee, Beom Jin Kim, Dong Hyun Sinn, Kyu Taek Lee, Jong Chul Rhee Bacteriologic Culture During ERCP: Technique, Results and Clinical Impact Ramu Raju, Daniel P. Hammond, Michele B. Delenick, Burr J. Loew, Andreas M. Stefan, Arathi Rao, Douglas A. Howell* Endoscopic Sphincterotomy Using the Heiss-Device Endoscopic Scissor in Patients with a Billroth II Gastrectomy Hyun Jong Choi*, Jong Ho Moon, Hyun Cheol Koo, Young Koog Cheon, Young Deok Cho, Joon Seong Lee, Moon Sung Lee, Chan Sup Shim

T1509

Radiation Exposure During ERCP: Critical Determinants Edward Y. Kim*, Mark McLoughlin, Eric C. Lam, Jack Amar, Michael F. Byrne, Jennifer J. Telford, Robert A. Enns

T1510

SPYGLASS Cholangioscopy— Impact On Patients with Bile Duct Filling Defect(s) of Uncertain Etiology Ayman M. Abdel Aziz*, Stuart Sherman, Kenneth F. Binmoeller, Jacques M. Deviere, Robert H. Hawes, Oleh Haluszka, Horst Neuhaus, Douglas Pleskow, Isaac Raijman

T1511

T1512

ASGE Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

OUTCOMES IN ENDOSCOPY T1513

T1514

P-262

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL T1529

Outcomes of Endoscopic Ampullectomy in the Elderly Nam Q. Nguyen*, Kenneth F. Binmoeller

T1530

Predictive Risk Factors for Rebleeding and Thirty-Day Mortality After Endoscopic Hemostasis in Elderly Bleeding Peptic Ulcer Patients Masao Toki*, Yasuharu Yamaguchi, Kenji Nakamura, Kei Aoki, Shin-ichi Takahashi

T1531

Bolus Dosing for Moderate Sedation Reduces Procedure Time During Esophagogastroduodenoscopy (EGD) Anthony Aghenta*, Ayodele T. Osowo, Vinodh Jeevanantham, Deerajnath Lingutla, Tarun Kothari

T1532

Bolus Dosing for Moderate Sedation Reduces Procedure Time During Colonoscopy Anthony Aghenta*, Ayodele T. Osowo, Vinodh Jeevanantham, Deerajnath Lingutla, Tarun Kothari

T1533

Incomplete Colonoscopy: Rate and Associated Factors At a VA Medical Center Endoscopy Unit Brindusa Truta*, Nooman Gilani, Francisco C. Ramirez

T1534

Prophylactic Octreotide for Prevention of Post-ERCP Pancreatitis: A Meta-Analysis Abhishek Choudhary*, Matthew L. Bechtold, Srinivas R. Puli, Mohamed O. Othman, Wilson P. Pais, Mainor R. Antillon, Praveen K. Roy

T1543

Retrograde/Antegrade (“Rendezvous”) Endotherapy of Complete Esophageal Occlusion Jennifer Brenner*, Patrick M. Lynch, Michael J. Wallace, Alexander A. Dekovich

T1545

Timing of Urgent Endoscopy for Upper Gastrointestinal Bleeding According to Clinical Criteria: A Prospective Study Leonardo Tammaro*, Maria Carla Di Paolo, Angelo Zullo, Cesare Hassan, Sergio Morini, Sebastiano Caliendo, Lorella Pallotta

T1546

Effectiveness of Video Capsule Endoscopy (VCE) and Double Balloon Enteroscopy (DBE) in Diagnosis and Treatment of Small Bowel Pathology Pavan Manchikalapati*, Valentine M. Ebuh, Irfan Syed, Ramanakumar V. Agnihothram, Anne Foley, Kanishka Bhattacharya, David R. Cave

T1547

The Impact of Annual Procedure Volume and Specialty On Colonoscopy Quality Eric Y. Lee*, David Swartz, Brett Jones, Cameron J. Bell, Ian D. Norton

T1548

Modified Sandwich Method in Endoscopic Cyanoacrylate Injection: An Attempt to Decrease Ectopic Embolism Chang Zheng Li

T1535

How Accurate Is Endoscopic Ultrasound in Staging Perirectal Nodal Invasion By Rectal Cancers? A MetaAnalysis and Systematic Review Srinivas R. Puli*, Jyotsna BK Reddy, Matthew L. Bechtold, Praveen K. Roy, Jack D. Bragg, Priya D. Ravindran, Jamal A. Ibdah, Mainor R. Antillon

T1549

Use of Nafamostat Mesilate and Gabexate Mesylate in the Prevention of Post-ERCP Pancreatitis and Risk Factor Analysis: A Prospective, Randomized Trial Cheol Woong Choi*, Dae Hwan Kang, Gwang-Ha Kim, Geun-Am Song, Jae-Sup Eum, Sang-Yong Lee, Hyoung-Yoel Park

T1536

Recommendation for the Current Endoscopic Technique in the Surveillance of HNPCC Gene Carriers Robert Hüneburg*, Tilman Sauerbruch, Christof Lamberti

T1550

T1537

Impact of Endoscopist'ST Experience On Success Rate of En-Bloc and En Bloc-Cure of Large Colorectal Polyps By Endoscopic Submucosal Dissection: A Meta-Analysis and Systematic Review Srinivas R. Puli*, Yasuo Kakugawa, Takuji Gotoda, Jyotsna BK Reddy, Daphne Antillon, Yutaka Saito, Mainor R. Antillon

The MID-Term Clinical Outcome of Colorectal Endoscopic Submucosal Dissection (ESD) Tsuyoshi Kikuchi*, Yutaka Saito, Takahisa Matsuda, Takeshi Nakajima, Toshio Uraoka, Shinsuke Kiriyama, Haruhisa Suzuki, Shusei Fukunaga

T1551

Does Size Really Matter? A Prospective Study to Evaluate Body Habitus and Difficulty Level of Colonoscopy Prashant Krishnan*, Robert Dempsey, Ali Nawras

T1552

Acupuncture for Diagnostic Upper Endoscopy in Adults: A Randomized Sham-Controlled Trial Wing Wa Leung*, Wilfred L. Mui, Simon S. Ng, Janet F. Lee, Enders K. Ng, James Y. Lau

T1553

Comparison of the Outcome of Endoscopic Submucosal Dissection (ESD) Using Sodium Hyaluronate and Needle-Knife Versus Endoscopic Aspiration Mucosectomy (EAM) for Esophageal Squamous Cell Neoplasm Masafumi Sakaguchi*, Makoto Nishimura, Kouichi Nonaka, Syuya Yoshinaga, Hideki Kitada, Hironori Yamamoto, Kentaro Sugano

T1554

Does Abnormal Computed Tomography of the Gastrointestinal (GI) Tract Correlate with Endoscopic Findings? Rekha Cheruvattath*, Stacy G. Prall, Amitpal Johal, Alan H. Wang, Robert E. Smith, Michael J. Komar, Nicholas A. Inverso

T1555

Patient Acceptance, Convenience and Efficacy of OneDay Versus Two-Day Colonoscopy Bowel Preparation Maqsood A. Khan*, Najia Wasiuddin, Michael D. Brown

T1556

Endoscopy Is Accurate, Safe and Effective in the Assessment and Management of Complications Following Gastric Bypass Surgery Jeffrey K. Lee*, Jacques Van Dam, John M. Morton, Myriam Curet, Subhas Banerjee

T1538

Propofol vs. Traditional Sedation Agents for Colonoscopy: A Meta-Analysis Harminder Singh*, William Poluha, Mary S. Cheang, Nicole Choptain, Ken I. Baron, Shayne P. Taback

T1539

Non-Aggressive Cystoscopy-Guided Debridement and Vigorous Irrigation for the Treatment of Organized Pancreatic Necroses Patricia Anne I. Cabral*, Ma. Cecilia M. Sison, Mark Anthony A. De Lusong, Tonya R. Kaltenbach, Roy M. Soetikno, Kenneth F. Binmoeller

T1540

The Efficacy of Argon Plasma Coagulation for Gastric Adenoma Eun Ran Kim*, Hoi Jin Kim, Young-Ho Kim, Dong Kyung Chang, Hee Jung Son, Poong-lyul Rhee, Jae J Kim, Jong Chul Rhee

T1541

T1542

The Risk of Re-Bleeding After An Index GI Bleed in Patients On Anticoagulation Barry Cukor*, Byron L. Cryer Endoscopic Dilation of Gastrojejunal Anastomotic Strictures After Laparoscopic Gastric Bypass. Predictors of Initial Failure Jorge C. Espinós*, Mariel Da Costa, Alfredo Mata, Jose M. Roca, Jesus Turro

Denotes DDW Poster of Distinction

P-263

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y

T1557

Oval Cup Forceps Versus Serrated Jaw Forceps in Gastric Biopsy Daniel A. Sussman*, Amar R. Deshpande, Ana Maria Medina, Robert Poppiti, Luigi X. Cubeddu, Jamie S. Barkin

T1558

Intravenous Metoclopramide to Increase Mucosal Visualization During Endoscopy in Patients with Acute Upper Gastrointestinal Bleeding: A Randomized, Controlled Study Daniel A. Sussman*, Amar R. Deshpande, Javier L. Parra, Afonso C. Ribeiro

MAY 20 T1559

Efficacy of Endoscopic Variceal Ligation for Esophageal Varices in Patients with Hepatocellular Carcinoma, Comparison with Patients Without Hepatocellular Carcinoma Hiroshi Araki*, Yuko Kimura, Yoichi Yasuda, Fumito Onogi, Takashi Ibuka, Masahito Nagaki, Tomohiro Kato, Hisataka Moriwaki

T1560

Comparison of Effectiveness of Interventional Endoscopy in Bleeding Peptic Ulcer According to the Timing of Endoscopy Hyun Seok Cho*, Dong Soo Han, Tae Jun Byun, Tae Yeob Kim, Chang Soo Eun, Yong Cheol Jeon, Joo Hyun Sohn

T1561

Documentation of Complete Colonoscopy; Can We Do It Better? Sebastian n. Abadie*, Mahfuzul Haque

T1562

Propofol Sedation in Colonoscopy: Bolus Administered By a Nurse (BAN) Vs Pump Continuous Infusion (PCI) Controlled By the Endoscopist. It Is Possible to Replace the Nurse? Francisco Igea*, Ferran Gonzalez-Huix, Montserrat Figa, Carlos Huertas

T1563

T1564

How Accurately Do Patients Report Their Colonoscopy Results? Lisa Madlensky*, Barbara H. Jung, Gerald L. Tolbert, Sepideh Safari, John M. Carethers Diagnostic Yield of Colonoscopy in Colorectal Cancer Screening Among Under 50-Year-Old Subjects Federico Tobal*, Valeria Pogorelsky, Daniel Tobal

T1565

Association of Colonoscopic Findings and Clinical Symptoms of Intestinal Involvement in Behcet's Disease Yun Jung Lee*, Sung Hee Jung, Hyang Ie Lee, Hyeon Woong Yang, Jeong Eun Shin, An Na Kim, Sang-Woo Cha

T1566

Assessment of Efficacy, Short-Term Outcome and Predictive Factors of N-Butyl-2-Cyanoacrylate (Histoacryl) Injection for Bleeding Gastric Varices (BGV) in Hispanic Population Evelyn Altamirano*, Rosario Valdés, Adalberto Corral, Angel M. Zarate, Santiago Camacho

T1567

T1568

T1569

P-264

Is Gastrointestinal Endoscopy Safe in the Setting of Recent Coronary Artery Reperfusion Therapy?: A Pilot Study Simona Meca*, Mirela Meca, Ari J. Wiesen, Jaydeep Kadam, Kostas Sideridis, Simmy Bank Assessing ERCP Degrees-of-Difficulty Pre-Procedurally: How Accurate Are We? Anthony Schore*, Laith H. Jamil, Marwan S. Ghabril, David S. Loeb, Stephen Lange, Michael B. Wallace Outcomes of Endoscopic Submucosal Dissection (ESD) in Colorectal Neoplasms Over 3 Years in Korea Bong Min Ko*, Moon Sung Lee, Hyun Jong Choi, Su Jin Hong, Chang Beom Ryu, Jong Ho Moon, Jin-Oh Kim, Joo Young Cho, Joon Seong Lee, Chan Sup Shim, Boo Sung Kim

T1570

Colon Cancer in VA Octogenarians with Previous Cscope But New Symptoms: Is Another C-scope Indicated? Rozina Mithani*, Stephen J. Sontag, Thomas G. Schnell, Jack Leya, Hines GI Fellows Loyola

T1571

Requesting Outside Hospital Endoscopy Records Before Repeating C-Scopes in VA Patients: Does the Delay Cause Harm? Lesley K. Andrews*, Stephen J. Sontag, Thomas G. Schnell, Jack Leya, -Loyola GI Fellows Hines,

T1572

A Fully-Covered Stent (Alimaxx-E™) for the Palliation of Dysphagia from Esophageal and Gastric Cardia Cancer: A Prospective Study Madeleen Uitdehaag*, Jeanin van Hooft, E. M. Verschuur, Alessandro Repici, E. W. Steyerberg, Paul Fockens, E. J. Kuipers, Peter D. Siersema

T1573

Palliation for Malignant Gastric Outlet Obstruction: A Prospective Quality of Life Study Carl R. Schmidt*, Hans Gerdes, William G. Hawkins, Erica Zucker, Qin Zhou, Elyn Riedel, David P. Jaques, Arnold J. Markowitz, Daniel G. Coit, Mark A. Schattner

T1574

Quality of Life After Esophagectomy and Endoscopic Therapy for Barrett's Esophagus with High-Grade Dysplasia or Intra-Mucosal Carcinoma Drew Schembre*, Andrew D. Arai, Shaula M. Levy, Margaret Farrell-Ross, Donald E. Low

ASGE Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

PEDIATRIC T1575

Safety, Feasibility and Usefulness of Rectal Endoscopic Ultrasonography (EUS) for Pediatric Anal and Perianal Complaints Veronique D. Morinville*, Sarto C. Paquin, Anand Sahai

T1576

Video Capsule Endoscopy in Paediatric Peutz-Jegher's Syndrome: A Blinded Comparison with Barium FollowThrough for the Detection and Management of SmallBowel Polyps Aymer Postgate*, Warren Hyer, Aine Fitzpatrick, Chris H. Fraser

T1577

Outcomes of Work-Up for Suspected Sphincter of Oddi Dysfunction in Children Shehzad Saeed*, Charles M. Wilcox, Shyam Varadarajulu

T1578

Risks and Efficacy of Errcp in Infants with Obstructive Jaundice Radan Keil*, Jiri Drabek, Michal Procke, Jiri Snajdauf, Jan Stovicek

T1579

The Detection of Small Intestinal Pathology By Wireless Capsule Endoscopy in Young Children Less Than Age 8 Years Annette Fritscher-Ravens*, Peter Scherbakov, Philip Bufler, Mike Thomson, Hannu U. Nuutinen, Luigi Dall'Oglio, Tarja Ruuska, Peter Milla

T1580

Double-Balloon Enteroscopy: A Pediatric Experience Tom K. Lin*, Jane P. Balint, Steven H. Erdman

T1581

Is Gastroscope Better Than Colonoscope in Pediatric Colonoscopy? Thirumazhisai S. Gunasekaran*, Shikha Singla, Mary Dahlberg, Hector Hernandez, James H. Berman

T1582

Therapeutic ERCP in Children with Biliary Complications Following Liver Transplantation Nandini Channabasappa*, Naveen Mittal, Bradley A. Barth

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL T1583

The Prevalence of Obesity in Children and Adolescence with Gastro-Esophageal Reflux Disease: A Clinical-Based Study Hoda M. Malaty*, J. K. Fraley, Kenneth Fairly, Sayed U. Javed, Nora Mattek, Suhaib Abudayyeh, Mark A. Gilger

T1584

Use of a Adult Gastroscope with a Distally Attached Cap Is Highly Effective for Total Colonoscopy in Young Pediatric Patients Kang Seok Seo*, Sang Wook Park, Gun Young Hong

ASGE Poster Session 8:00 AM - 5:00 PM

T1595

The Significance of Initial Values of Blood Pressure and Heart Rate in the Evaluation of Prognosis in Patients with Acute Bleeding in the Upper Part of Gastrointestinal Tract Marketa Buresova*, Radan Keil, Jana Golanova, Ludek Hrdlicka, Jiri Drabek, Jan Stovicek

T1596

A Validation and Comparison of the Blatchford, PreEndoscopic Baylor and Clinical Rockall Scoring Systems in Predicting the Need for Therapeutic Endoscopy (TE) in Patients with Upper Gastrointestinal Haemorrhage (UGIH) Sandy H. Pang*, Jessica Ching, James Y. Lau, Joseph J. Sung, David Y. Graham, Francis K. L. Chan

Sails Pavilion San Diego Convention Center T1597

Adenomatous Vs Non-Adenomatous Ampullary Lesions. 10 Year Results from a Single Referral Center Shayan Irani*, Andrew D. Arai, Kamran Ayub, John J. Brandabur, Russell Dorer, Margaret Farrell-Ross, Michael Gluck, Geoffrey Jiranek, David Patterson, Drew Schembre, Richard A. Kozarek

Gastric Antral Vascular Ectasia (GAVE) to Prevent Bleeding-Induced Anemia in Patients with Portal Hypertension Tomohiro Kato*, Hiroshi Araki, Akihiko Sugiyama, Hideki Hayashi, Youichi Nishigaki, Eiichi Tomita

T1598

Feasibility of Interventional Double-Balloon Enteroscopy After Small Bowel Reconstructive Surgery Tom G. Moreels*, Bernard Roth, Elisabeth J. Macken, Marc J. Van Outryve, Paul A. Pelckmans

Effect of High Dose Oral rabeprazole On Recurrent Bleeding After Endoscopic Treatment of Bleeding Peptic Ulcers: A Preliminary Report Hyung-Keun Kim*, Jin Soo Kim, Young-Seok Cho, YongWan Park, Hye-Suk Son, Hiun Suk Chae

T1599

Effect of Procedural Factors On the Success Rate of Complete Double-Balloon Enteroscopy Tom G. Moreels*, Bernard Roth, Elisabeth J. Macken, Marc J. Van Outryve, Paul A. Pelckmans

The Effectiveness of Asynchronous Tele-Endoscopy for Esophagogastroduodenoscopy Sean Pritchett*, Anushiya Sathiananthan, Joseph Cafazzo, Peter G. Rossos

T1600

Is Capsule Endoscopy Helpful As a Diagnostic Tool in the Evaluation of Non Bleeding Indications? Katherine M. Hoda*, Glenn M. Eisen, Brintha K. Enestvedt, Atif Zaman

T1601

Adherent Clots- To Treat or Not to Treat? Brintha K. Enestvedt*, Ian M. Gralnek, Nora Mattek, David A. Lieberman, Glenn M. Eisen

Predictors for Small Bowel Tumours in Capsule Endoscopy: Are There Any? Joanna K. Law*, Pongphob Intaraprasong, Pooya Kazemi, Lukasz Soswa, Amyeen Hassanali, Isaiah D. Bregman, Wiley Chung, Samuel E. Krausz, Robert A. Enns

T1602

Applicability of the Rockall Scoring System and Prediction of Rebleeding and Mortality After Combined Pharmacologic and Endoscopic Treatment of High-Risk Bleeding Peptic Ulcers Esteban Saperas*, Sebastian Videla, Carolina Bayarri, Joan Dot, Jose Ramon Armengol, Juan Ramon Malagelada

Enhanced Diagnostic Yield with Increased Small Bowel Transit Time During Capsule Endoscopy Jonathan M. Buscaglia*, Sumit Kapoor, John O. Clarke, Priscilla Magno, Samuel A. Giday, Elaine Yong, Gerard E. Mullin

T1603

Rockall Risk Stratification of Non-Variceal Upper GI Bleed in a Community Teaching Hospital and Its Accuracy in the Setting of Pro-Hemorrhagic Medications Demosthenes G. Papamatheakis*, Mona D. Patel, Bonita Singal, Eileen A. Robinson, Naresh T. Gunaratnam

Prospective Evaluation of Patients Referred for Obscure Bleeding: How Many Patients Actually Have Small Bowel Bleeding? Update At One Year John Staples*, Mark McLoughlin, Pardis Lakzadeh, Iman Zandieh, Jaber Al Ali, Robert A. Enns

T1604

Interobserver Agreement On Interpretation of Capsule Endoscopy Findings Based On Capsule Endoscopy Structured Terminology (CEST): The Korean Gut Image Study Group, Multi-Center Study Youn Sun Park*, Byung-Ik Jang, Kyeong Soo Lee, Ki-Nam Shim, Yong Sik Kim, Hoon Jai Chun, Kyung Jo Kim, Kwang Jae Lee, Ji Kon Ryu, Dong Kyung Chang, Jeong Seop Moon, Myung-Gyu Choi, In Seok Lee, Dae Young Cheung, Jin-Oh Kim, Jae Hee Cheon, Cheol Hee Park, Jeong-Sik Byeon

T1605

Endoscopic Microvascular Architecture of the Gastric Mucosa with Portal Hypertension On Narrow Band Imaging SEISHU HAYASHI

T1606

Computed Virtual Chromoendoscopy: Usefulness for Identification of Histologically Normal Mucosa in the Gastric Corpus Arved W. Schneider*, Hartmut Vogell, Marc Naumann, Petra R. Uhlen, Gabriele Grebe-Schultheis

STOMACH/SMALL INTESTINE T1585

T1586

T1587

T1588

T1589

T1590

T1591

Depth of Hemoclipping, Gross Injury, Histologic Inflammation & Fibrosis with Different Hemoclips or MPEC in a Randomized Hemostasis Study of Chronic Canine Ulcers Dennis M. Jensen*, Gustavo A. Machicado, Bhavneet Singh, Ken Hirabayashi

T1592

Predictors of Outcome for Patients with GI Bleeding Attending An Urban Tertiary Hospital N. Jewel Samadder*, Gesine L. Alders, Maria Braganza, Mahsa Mashouf-Fard, Gabor Kandel, E. Jan Irvine

T1593

Argon Plasma Coagulation vs. Bipolar Electro Coagulation in the Endoscopic Treatment of Bleeding Peptic Gastroduodenal Ulcers (Results of Ongoing Prospective Randomized Trial) Evgeny D. Fedorov*, Oleg I. Yudin, Dmitry Y. Petrov, Ekaterina V. Ivanova

T1594

Depth of Hemoclip Attachment, Tissue Injury, & Fibrosis After Hemostasis of Bleeding Acute Canine Gastric Ulcers in a Randomized Controlled Study Dennis M. Jensen, Gustavo A. Machicado*, Bhavneet Singh, Ken Hirabayashi

Denotes DDW Poster of Distinction

P-265

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y

T1607

T1608

MAY 20 T1609

T1610

Diagnostic Yield of Capsule Endoscopy in Elderly Patients with Obscure GI Bleeding and Predictive Factors of Rebleeding: A Prospective Multicenter Study of the ANGH Group Stéphane Nahon*, Antoine Fleury, Emmanuel Cuillerier, Gilles d'Abrigeon, Anne Courillon-Mallet, Thierry Morin, Christophe Locher, Pierre Lahmek

T1618

Percutaneous Endoscopic Gastrostomy in Patients with Amyotrophic Lateral Sclerosis: Role of BiPAP-Ventilation Janek Binek*, Boudewijn van der Weg, Christa Meyenberger, Christina A. Knellwolf, Andreas L. Knoblauch, Markus Weber

T1619

Understanding Mortality After Gastrostomy Tube Insertion: Use of a Survival Model Based On CoMorbidity Gaius Longcroft-Wheaton*, Peter Marden, Ben Colleypriest, Daniel Gavin, Gordon Taylor, Mark Farrant

T1620

A New Technique for Direct Percutaneous Endoscopic Jejunostomy Using Double Balloon Endoscopy and Magnetic Anchors in a Porcine Model Tomonori Yano*, Keijiro Sunada, Mitsuyo Yoshizawa, Masato Shigemori, Hirotsugu Sakamoto, Tomohisa Nakaya, Hiromi Fukushima, Daisuke Tsukui, Tetsuro Honda, Takashi Kitade, Yuuichi Iwashita, Takahito Takezawa, Norikatsu Numao, Aya Kitamura, Hozumi Tanaka, Eiji Kobayashi, Hironori Yamamoto, Kentaro Sugano

Complications and More: Results of the German Prospective DBE-Database By the German DBE Study Group Oliver Moeschler*, Andrea May, Michael K. Mueller, Christian Ell

T1621

Prospective Multicenter Long Term Follow Up Results of New Introducer Percutaneous Endoscopic Gastrostomy Method with Gastropexy in 89 Patients Yogesh Shastri*, Angelika Tessmer, Nicolas Hoepffner, Jürgen Stein

Prevalence of Small Bowel Bleeding in Patients with Gastrointestinal Overt Bleeding: A Multi-Center Experience of 1052 Consecutive Patients Hirotoshi Okazaki*, Yasuhiro Fujiwara, Satoshi Sugimori, Natsuhiko Kameda, Hirohisa Machida, Tetsuya Tanigawa, Masatsugu Shiba, Kenji Watanabe, Kazunari Tominaga, Toshio Watanabe, Nobuhide Oshitani, Tetsuo Arakawa

T1622

Estimation of the Depth of Double Balloon Enteroscopy (DBE) Passage in the Small Intestine: Is It Possible to Simplify the Process? Simon K. Lo*, Shahab Mehdizadeh

T1623

Factors Influencing the Diagnostic Yield of Capsule Endoscopy (CE) in Patients with Obscure Gastrointestinal Bleeding (OGIB) Diego Garcia-Compean*, Ricardo Flores Rendon, César A. Marrufo-García, Jesus D. De Leon, Jose A Gonzalez, Arturo Armenta, Hector J. Maldonado

T1624

Capsule Endoscopy Predicts the Success and Route of Insertion for Double Balloon Enteroscopy Vaibhav Mehendiratta*, Mitchell Conn, Anthony Infantolino, Michael C. DiMarino, Leo C. Katz, David M. Kastenberg

T1625

A Pilot Study of Spiral Enteroscopy Using a New Design 48F Discovery SB Overtube and the Fujinon 200cm X 9.4mm Enteroscope Paul A. Akerman*, Daniel Cantero, Jose Avila, Jesus Pangtay

T1626

A New In Vitro Porcine Model for Spiral Enteroscopy Training: The Akerman Enteroscopy Trainer Paul A. Akerman*, Daniel Cantero, William H. Bookwalter, Robert Ailinger

T1627

A Pilot Study of Spiral Enteroscopy Using a New Design 48F Discovery SB Overtube and the Olympus 200 CM X 9.2mm Enteroscope Paul A. Akerman*, Daniel Cantero, Jose Avila, Jesus Pangtay

T1628

Clinical Diagnosis of Small Bowel Metastasis in Malignant Melanoma Joerg G. Albert*, Peter Helmbold, Martin Fechner, Eckhard Fiedler, Winfried A. Voderholzer, Wolfgang C. Marsch, Herbert Lochs, Wolfram Sterry, Sonja Vay, Wolfgang Stremmel, Matthias M. Dollinger

T1629

Reduction of the Capture Rate in the Stomach Can Increase Complete Examination Rate of Capsule Endoscopy: A Prospective Randomized Controlled Trial Zhuan Liao*, Feng Li, Zhao-Shen Li

T1630

Clinical Application of Omom Capsule Endoscopy in China: A Review of 1,068 Cases Zhuan Liao*, Feng Li, Zhao-Shen Li

T1631

Complications, Complete Examination Rate and Gastrointestinal Transit Time of Omom Capsule Endoscopy: An Analysis with 1,068 Cases Zhuan Liao*, Feng Li, Zhao-Shen Li

Value of Chromo-Magnification Endoscopy and Targeted Biopsies in the Diagnosis of Celiac Disease with Previously Negative Histology: A Preliminary Study Annalisa Pascariello, Carolina Ciacci*, Ilaria Russo, Luca Magno, Giuseppe Galloro, Paola Iovino

T1611

Nasopharyngeal Selective Decolonization Is Not An Effective Measure to Prevent Percutaneous Endoscopic Gastrostomy Infection - A Randomized Controlled Trial Sandra Faias*, Marília Cravo, Isabel Claro, Susana Mão-deFerro, Carlos N. Leitão

T1612

A New Device for the Introducer Percutaneous Endoscopic Gastrostomy Technique José H. Giordano-Nappi, Shinichi Ishioka, Fauze MalufFilho*, Fabio Y. Hondo, Sergio E. Matuguma, Ivan Cecconello, Paulo Sakai

T1613

T1614

T1615

T1616

T1617

P-266

Endoscopic and Histopathologic Characteristics Suggesting Coexisting Focus of High Grade Adenoma or Cancer in the Cases Diagnosed As Low Grade Gastric Adenoma By Forceps Biopsy Byung-Hoon Min*, Eun Ran Kim, Jae J Kim, Hoi Jin Kim, Jun Haeng Lee, Dong Kyung Chang, Young-Ho Kim, Hee Jung Son, Poong-lyul Rhee, Jong Chul Rhee Racial Disparities in Utilization and Timing of Percutaneous Endoscopic Gastrostomy (PEG) Placement in 21,558 Noncancer Medicare Patients with Alzheimer's Dementia Joshua D. Novak*, Tzuyung D. Kou, Gregory S. Cooper, Richard C. Wong Charlson Comorbidity Index As a Predictor of Percutaneous Endoscopic Gastrostomy (PEG) Placement in 21,558 Noncancer Medicare Patients with Alzheimer's Dementia Joshua D. Novak*, Tzuyung D. Kou, Gregory S. Cooper, Richard C. Wong New Glycogel Wound Dressing Modality for Peristomal PEG Dressing: A Simple, Convenient, Economical and Better Option Dietmar Borger*, Loitsch Stefan Marcel, Yogesh Shastri, Angelika Tessmer, Franz Hartmann, Jürgen Stein Percutaneous Endoscopic Gastrostomy: An Eight-Year Prospective Follow Up Sudarshan Paramsothy*, Lindsay Mollison, Rupert W. Leong

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL T1632

Right Lateral Position Improves Complete Examination Rate of Capsule Endoscope: A Prospective Randomized, Controlled Trial Zhuan Liao*, Feng Li, Zhao-Shen Li

T1633

Additional Value of Distal DBE in Patients with Occult GI Bleeding and Normal Findings On Previous Incomplete Proximal DBE Peter B. Mensink*, Henk R. van Buuren, Jelle Haringsma, E. J. Kuipers

T1634

T1635

Management of Small-Intestinal Polyps in Peutz-Jeghers Syndrome By Using Double Balloon Enteroscopy and Videocapsule Endoscopy Naoki Ohmiya*, Wataru Honda, Masanao Nakamura, Osamu Shirai, Hiroyuki Takenaka, Masaaki Kurahashi, Ayumu Taguchi, Akihiro Itoh, Yoshiki Hirooka, Yasumasa Niwa, Osamu Maeda, Takafumi Ando, Hidemi Goto Double Balloon Enteroscopy Facilitates Direct Percutaneous Endoscopic Jejunostomy Placement Orlando Lopez-Roman*, Andrew S. Ross, Charles E. Dye, Carol E. Semrad

T1636

Health-Related Quality of Life in Patients with Chronic Gastrointestinal Hemorrhage Lauren B. Gerson*, Nighat Ullah

T1637

Patients with Small Bowel Angiodysplasia Treated with Argon Beamer During Double Balloon Enteroscopy. Prospective Study with One Year Follow Up Jorge C. Espinós*, Alfredo Mata, Begoña Gonzalez, Montserrat Forné, Mariel Da Costa, Jesus Turro

T1638

The Influence of NSAIDs Use On Diagnosis of Obscure GI Bleeding At Double Balloon Endoscopy Yusuke Hashimoto*, Yuichiro Kuroki, Yutaka Endo, Naotaka Maruoka, Osamu Ogawa, Hiroki Yoshikumi, Makoto Yoshiba

T1639

Retrograde Per Anal Double Balloon Enteroscopy (RDBE) Is a Successful Technique for the Diagnosis and Therapeutic Intervention of a Wide Variety of Small Intestinal Luminal Lesions David M. Poppers*, Eric Rosen, Aman Ali, Evin J. McCabe, Gregory B. Haber

T1640

Double Balloon Enteroscopy in Recipients of Simultaneous Enteric-Drainaged Pancreas-Kidney Transplantation - Initial Experience Janusz Milewski, Marek Durlik, Wojciech Kosmala, Agnieszka Serwacka, Grazyna Rydzewska*, Andrzej Rydzewski

T1641

Clinical Impact of Double Balloon Endoscopy On the Diagnosis of Malignant Small Bowel Tumors: A Single Center Experience Hirokazu Yamagami*, Nobuhide Oshitani, Takehisa Suekane, Noriko Kamata, Mitsue Sogawa, Hirotoshi Okazaki, Kenji Watanabe, Kazunari Tominaga, Toshio Watanabe, Yasuhiro Fujiwara, Tetsuo Arakawa

T1642

Usefulness of Double Balloon Endoscopy in Patients with Surgically Distorted Intestinal Anatomy Do Hoon Kim*, Jeong-Sik Byeon, Kee Don Choi, Byong Duk Ye, Soon Man Yoon, Mi Young Do, Seunghyun Kwon, Byunggyu Kim, Seung-Jae Myung, Suk-Kyun Yang, Jin-Ho Kim

T1643

Indications and Diagnostic Yield of Double Balloon Enteroscopy in a Tertiary Care Setting: An Analysis of 527 Cases with Suspected Small Bowel Diseases Jumpei Kondo, Shingo Tsuji*, Hideki Iijima, Masahiko Tsujii, Tsutomu Nishida, Katsumi Yamamoto, Shusaku Tsutsui, Norio Hayashi, Osaka University Affiliated Hospitals Small Bowel Study Group

T1644

The Efficacy of “Mother-Baby Technique” Enteroscopy for Patients with Small Bowel Strictures of Crohn's Disease Shuhei Hosomi*, Kenji Watanabe, Naoto Hirata, Takehisa Suekane, Noriko Kamata, Mitsue Sogawa, Hirokazu Yamagami, Kazunari Tominaga, Toshio Watanabe, Yasuhiro Fujiwara, Nobuhide Oshitani, Tetsuo Arakawa

T1645

Diagnosis and Endoscopic Therapy of Small-Intestinal Tumors Using Double Balloon Enteroscopy (DBE) and Videocapsule Endoscopy (VCE) Wataru Honda*, Naoki Ohmiya, Masanao Nakamura, Osamu Shirai, Hiroyuki Takenaka, Akihiro Itoh, Yoshiki Hirooka, Yasumasa Niwa, Osamu Maeda, Takafumi Ando, Hidemi Goto

T1646

Diagnostic Yield and Therapeutic Impact of Single Balloon Enteroscopy; A Series of 60 Patients with Suspected Small Bowel Disease Mohan Ramchandani*, D. N. Reddy, G. V. Rao, Santosh Darisetty

T1647

Negligible Effects of Erythromycin On Image Quality and Transit Time of Endoscopic Capsule: A Two-Center Study Eva Niv, Ido Bogner, Olga Barkay, Zamir Halpern, Elisabeth Mahajna, Yael Kopelman, Zvi Fireman*

T1648

Double-Balloon Enteroscopy Two-Year Experience At a Single Tertiary Centre Marcela Kopacova*, Ilja Tachecí, Stanislav Rejchrt, Jan Bures

T1649

Diagnostic Yield of Video Capsule Endoscopy (PillCam SB®) Outside the Small Bowel Emanuele Rondonotti*, Federica Villa, Valeria Saladino, Roberto de Franchis

T1650

Prevalence of Upper Gastrointestinal Symptoms Among School Age Children: A Community-Based Study Hoda M. Malaty*, Mark A. Gilger, Suhaib Abudayyeh, David Y. Graham, David Hollier

T1651

Double Balloon Enteroscopy Is Highly Effective: The First 100 Cases At St. Mark's Hospital, London Edward J. Despott*, Eric Tripoli, Adel Polecina, Krysia Konieczko, Chris H. Fraser

T1652

Frequency of Non-Small Bowel Etiologies of Obscure Gastroinestinal Bleeding in Patients Referred for Double Balloon Enteroscopy Michael Bellutti*, Lucia C. Fry, Klaus Mönkemüller, Helmut Neumann, Peter Malfertheiner

T1653

Wireless Capsule Endoscopy Gastric and Small Bowel Transit Time and Completeness of the Examination in Patients with Glucose Tolerance Abnormalities or Renal Dysfunction in Japan Mitsunori Maeda*, Kazunari Kanke, Michiko Nakano, Mina Hoshino, Michiko Yamagata, Akira Terano, Hideyuki Hiraishi

T1654

Diagnostic and Therapeutic Impact of Double Balloon Enteroscopy in Patients with Crohn's Disease Michael Bellutti*, Lucia C. Fry, Klaus Mönkemüller, Helmut Neumann, Ulrike von Arnim, Peter Malfertheiner

T1655

Observation and Treatment of Small Bowel Diseases Using Single Balloon Endoscope Kazuo Ohtsuka*, Hiroshi Kashida, Kenta Kodama, Jun-ichi Ukegawa, Hiroshi Kanie, Ken-ichi Mizuno, Yui Kudo, Orie Takemura, Shin-ei Kudo

Denotes DDW Poster of Distinction

P-267

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y

T1656

Small Intestinal Mucosal Breaks with Short-Term Administration of Non-Steroidal Anti-Inflammatory Drugs Katya Gudis*, Shunji Fujimori, Yukie Yamada, Yoko Takahashi, Tsuguhiko Seo, Akihito Ehara, Tsuyoshi Kobayashi, Keigo Mitsui, Masaoki Yonezawa, Shu Tanaka, Atsushi Tatsuguchi, Choitsu Sakamoto

T1657

Evaluation of the Risk of Acute Pancreatitis in Patients Investigated By Double Balloon Enteroscopy: Results of the Prospective Clinical and Biological Evaluation of 40 Consecutive Patients Muriel Frederic, Michel Delvaux*, Isaac Fassler, Gerard Gay

MAY 20 T1658

T1659

Unique Redesign of Gadget for Improved DBE Procedure —Usefulness of Double Balloon Endoscopy for Common Chief Complaints and Adaptation of Simple Tool for Efficient Balloon Attachment— Shu Tanaka*, Katya Gudis, Yukie Yamada, Yoko Takahashi, Akihito Ehara, Tsuyoshi Kobayashi, Keigo Mitsui, Atsushi Tatsuguchi, Shunji Fujimori, Choitsu Sakamoto Factors That Help Predict the Bleeding Source in Patients with Obscure Gastrointestinal Bleeding Akihito Ehara*, Shu Tanaka, Atsushi Tatsuguchi, Katya Gudis, Yukie Yamada, Yoko Takahashi, Tsuyoshi Kobayashi, Yoshihisa Sekita, Tsuguhiko Seo, Keigo Mitsui, Masaoki Yonezawa, Yoshiaki Shibata, Shunji Fujimori, Choitsu Sakamoto

T1666

Successful Endoscopic Balloon Dilation Therapy with Infliximab for Crohn's Strictures Keijiro Sunada*, Tomonori Yano, MIchiko Iwamoto, Tomohiko Miyata, Masayuki Arashiro, Hironari Ajibe, Hiromi Hukushima, Norikatsu Numao, Aya Kitamura, Takahito Takezawa, Tomohisa Nakaya, Takashi Kitade, Tetsuro Honda, Hirotsugu Sakamoto, Daisuke Tsukui, Masato Shigemori, Yuuichi Iwashita, Yoshikazu Hayashi, Hironori Yamamoto, Kentaro Sugano

T1667

What Is the Role of Intraoperative Enteroscopy in the Management of Obscure GI Bleeding After the Development of Video Capsule Endoscopy? Richard Douard*, Philippe Wind, Anne Berger, Thibaut Maniere, Christophe Cellier, Paul-Henri Cugnenc

T1668

Usefulness of Double-Balloon Enteroscopy As a Diagnostic and Therapeutic Tool in Crohn's Disease Osamu Watanabe*, Takafumi Ando, Osamu Maeda, Kazuhiro Ishiguro, Daisuke Ishikawa, Motofusa Hasegawa, Shinya Kondo, Tsuyoshi Kato, Naoki Ohmiya, Yasumasa Niwa, Hidemi Goto

T1669

Usefulness of Capsule Endoscopy and Double Balloon Enteroscopy in Juvenile Patients Tae Hee Lee*, Jin-Oh Kim, Keun Hyok Cho, Soo Hoon Eun, Bong Min Ko, Su Jin Hong, Joo Young Cho, Joon Seong Lee, Moon Sung Lee, So Young Jin, Chan Sup Shim, Boo Sung Kim

T1660

Predicting the Probability of Malignancy in Small Intestinal GIST By Double Balloon Endoscopy Yukie Yamada*, Shu Tanaka, Atsushi Tatsuguchi, Katya Gudis, Yoko Takahashi, Akihito Ehara, Tsuyoshi Kobayashi, Yoshihisa Sekita, Tsuguhiko Seo, Keigo Mitsui, Masaoki Yonezawa, Yoshiaki Shibata, Shunji Fujimori, Choitsu Sakamoto

T1670

Trends in Epidemiology and Therapy of Upper Gastrointestinal Hemorrhage from Gastroduodenal Ulcer Disease - The UT Southwestern GI Bleed Team Experience Luis F. Lara*, Jayaprakash Sreenarasimhaiah, Shou Jiang Tang, Samir Gupta, Prabhakar P. Swaroop, William C. Santangelo, William M. Lee, Don C. Rockey

T1661

Clinical Efficacy and Long-Term Follow-Up After Endoscopic Treatment with Double-Balloon Enteroscopy for Hemorrhagic Small Intestinal Diseases Natsuhiko Kameda*, Hirotoshi Okazaki, Satoshi Sugimori, Hirohisa Machida, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Kenji Watanabe, Toshio Watanabe, Kazunari Tominaga, Yasuhiro Fujiwara, Nobuhide Oshitani, Kazuhide Higuchi, Tetsuo Arakawa

T1671

Repeat Gastroscopy After Initial Diagnosis of Benign Gastric Ulcer Has a Low Yield of Detecting Cancer Sam Al-Sohaily*, Vid P. Suttor, Robert G. Batey, Rupert W. Leong

T1672

Helicobacter pylori Diversity in Gastric Cancer and GERD Among Singapore Chinese Population Kwong Ming Fock*, Dhamodaran Subbiah, Eng Kiong Teo, Tiing Leong Ang

T1673

Validation in the Usual Practice of a Simultaneous Urea Breath Test During the Urgent Gastroscopy in the Peptic Bleeding Benito Velayos*, Luis Fernandez, Ana Almaraz, Rocío Aller, Lourdes Olmo, Fernando Calle, Teresa Arranz, Jose Manuel Gonzalez

T1662

Double Balloon Enteroscopy: A Leap Forward in the Management of Small Bowel Crohn's Strictures Edward J. Despott*, Eric Tripoli, Adel Polecina, Krysia Konieczko, Chris H. Fraser

T1663

Double Balloon Enteroscopy in Suspected Crohn's Disease: The KASID Multi-Center Trial Hyun Joo Jang*, Chang Soo Eun, Hwang Choi, Kyu Yong Choi, Dongil Park, Jung Ho Park, Dong Kyung Chang, Su Hee Park, Jin-Oh Kim, Bong Min Ko, Moon Sung Lee, Kyu Chan Huh, Jeong-Sik Byeon, Ki don Choi, Sung Jae Shin, Jai Hyun Choi

T1674

Association Between Small Intestinal White Villi and Capsule Gastric Transit Time Yoko Takahashi*, Shunji Fujimori, Katya Gudis, Yukie Yamada, Akihito Ehara, Tsuyoshi Kobayashi, Tsuguhiko Seo, Keigo Mitsui, Masaoki Yonezawa, Yoshiaki Shibata, Shu Tanaka, Atsushi Tatsuguchi, Choitsu Sakamoto

Comparison of the H. pylori Eradication Rate According to the Duration of First-Line Triple Therapy: A MetaAnalysis in Korea Hae Sun Jung*, Ki-Nam Shim, Min-Jung Kang, Ji Min Jung, Chang Yoon Ha, Youn Ju Na, Su Jung Baik, Seong-Eun Kim, Sung-Ae Jung, Sun Young Yi, Kwon Yoo, Il-Hwan Moon, Kyu Won Chung

T1675

Bisphosphonate Increases Risk of Peptic Ulcer in Rheumatoid Arthritis Patients On Long-Term NonSteroidal Anti-Inflammatory Drug Therapy Masafumi Kusunoki*, Kazumasa Miyake, Mariko Umezawa, Tomotaka Shindo, Nobue Ueki, Tetsuro Hiratsuka, Seiji Futagami, Katya Gudis, Taku Tsukui, Choitsu Sakamoto

T1676

Depressed White Spot in the Center of the Nodularity Is the Most Important Feature for Endoscopic Diagnosis of Nodular Gastritis Tomoari Kamada*, Manabu Ishii, Hiroaki Kusunoki, Hiroshi Imamura, Minoru Fujita, Ken-ichi Tarumi, Noriaki Manabe, Akiko Shiotani, Jiro Hata, Ken Haruma

T1664

T1665

P-268

The Efficacy of Infliximab for Small Bowel Lesions of Patients with Crohn's Disease According to the Evaluation By Using Capsule Endoscopy and Double Balloon Enteroscopy Kenji Watanabe*, Shuhei Hosomi, Takehisa Suekane, Noriko Kamata, Mitsue Sogawa, Hirokazu Yamagami, Kazunari Tominaga, Toshio Watanabe, Yasuhiro Fujiwara, Nobuhide Oshitani, Tetsuo Arakawa

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL T1677

T1678

Possible Role of Gastroprotective Agents On Preventing Gastroduodenal Mucosal Injury in Patients Taking LowDose Aspirin Takatsugu Yamamoto*, Taro Ishii, Kengo Hattori, Hajime Anjiki, Shin Nakayama, Kunitaka Nagasawa, Yukako Osaki, Hiroko Tsutsumi, Koichiro Abe, Masaki Sanaka, Yasushi Kuyama

Long-Term Results of Endoscopic Resection in Early Gastric Cancer: The Western Experience Hendrik Manner*, Thomas Rabenstein, Andrea May, Oliver Pech, Liebwin Gossner, Nicola Plum, Michael Vieth, Christian Ell

T1680

Feasibility of Endoscopic Submucosal Dissection for Early Gastric Cancer Arising from Remnant Stomach, Compared with Conventional Endoscopic Mucosal Resection Shu Hoteya*, Toshiro Iizuka, Naohisa Yahagi

T1682

T1683

T1684

T1685

T1686

T1687

T1688

An Experience for Investigation of Follow-Up Strategy for Incomplete ESD At Single Institute Joo Young Cho, Hyun Gun Kim*, Tae Hee Lee, Jin-Oh Kim, Joon Seong Lee, Bong Min Ko, Su Jin Hong, Moon Sung Lee, Chan Sup Shim, Seok R. Choi

T1690

Pathologic Relationship and Clinical Significance of Magnifying Endoscopy in Scar Lesions After Endoscopic Mucosal Resection for Early Gastric Neoplasm: Prospective Studies in Endoscopy Follow Up Tae Hoon Lee*, Il Kwun Chung, Suck-Ho Lee, Ji-Young Park, Jeong Hoon Park, Do Hyun Park, Hong-Soo Kim, Sang-Heum Park, Sun-Joo Kim

Immunological Status of the Stomach in Ulcerative Colitis and Crohn's Disease Takafumi Ando*, Osamu Watanabe, Osamu Maeda, Kazuhiro Ishiguro, Daisuke Ishikawa, Motofusa Hasegawa, Naoki Ohmiya, Yasumasa Niwa, Hidemi Goto

T1679

T1681

T1689

Should Every Low Grade Gastric Adenoma Be Resected? Soo-Jeong Cho*, Il Ju Choi, Chan Gyoo Kim, Jong Yeul Lee, Myeong-Cherl Kook Is Narrow Band Imaging with Magnifying Endoscopy Useful for the Estimate of Tumor Lateral Extent Before Endoscopic Submucosal Dissection for Early Gastric Cancer? - A Retrospective Analysis Compared with Chromoendoscopy Yoji Takeuchi*, Noriya Uedo, Ryu Ishihara, Hiroyasu Iishi Comparison of Endoscopic and Surgical Removal for Gastric Subepithelial Tumors Arising from Muscularis Propria Layer Kee Myung Lee*, Jae Chul Hwang, Jin Hong Kim, Young Bae Kim, Sung Jae Shin, Kwang Jae Lee, Byungmoo Yoo, Jae Youn Cheong, Sung Won Cho Analysis of Predictive Factors Related to Lymph Node Metastasis in Patients with Undifferentiated Early Gastric Cancers Kyu-Jong Kim*, Sun Jung Kim, Jung Sik Choi, Won Moon, Moo In Park, Seun Ja Park Argon Plasma Coagulation Therapy for Early Gastric Cancer Is Effective and Operator Independent Toshihiko Tomita*, Eitatsu Arai, Tomoaki Kohno, Takashi Kondo, Tomohiro Tsuji, Yongmin Kim, Tadayuki Oshima, Kazutoshi Hori, Takayuki Matsumoto, Hiroto Miwa Balloon Dilation for Benign Esophagojejunal Anastomotic Stricture After Total Gastrectomy for Gastric Cancer Chan Gyoo Kim*, Jong Yeul Lee, Soo-Jeong Cho, Jun Ho Lee, Keun Won Ryu, Young-Woo Kim, Il Ju Choi Safety and Efficacy of Carbon Dioxide (CO2) Insufflation During Endoscopic Submucosal Dissection (ESD) for Gastric Cancer Under Propofol Sedation: A Randomized, Controlled Trial Daisuke Tanioka*, Yoshiro Kawahara, Hiroyuki Okada, Ryuta Takenaka, Satoru Yagi, Masafumi Inoue, Seiji Kawano, Takao Tsuzuki, Masahide Kita, Keisuke Hori, Masayuki Uemura, Kazuhide Yamamoto Local Recurrence Rate of Gastric Cancer in Ten Years' Follow Up After Endoscopic Mucosal Resection: A Retrospective Cohort Study Noriyuki Horiki*, Fumio Omata, Masayo Tsukamoto, Naoki Ishii, Yoshiyuki Fujita

T1691

Endoscopic Mucosal Resection for Undifferentiated Early Gastric Cancer - Differential Approach Between Poorly Differentiated Adenocarcinoma and Signet Ring Cell Carcinoma Jie-Hyun Kim*, Yong Chan Lee, Hyunki Kim, Kyung Ho Song, Sang Kil Lee, Jae Hee Cheon, Jae Bock Chung

T1692

Comparison of Uncovered and Covered Stent for Endoscopic Treatment of Inoperable Malignant Gastroduodenal Obstruction Kee Myung Lee*, Sang Jo Choi, Jin Hong Kim, Sung Jae Shin, Jae Chul Hwang, Kwang Jae Lee, Byungmoo Yoo, Jae Youn Cheong, Sung Won Cho

T1693

Validity of Magnify NBI for Gastric Intestinal Metaplasia Targeted Biopsy Boonlert Imraporn, Sukprasert Jutaghokiat, Naruemon Wisedopas, Rungsun Rerknimitr*, Sombat Treeprasertsuk, Varocha Mahachai, Pinit Kullavanijaya

T1694

Clinical Significance of Expression of COX-2 and Cadherin in Gastric Cancer Kum Hei Ryu*, Ki-Nam Shim, Yang-Hee Joo, Hyun Joo Song, Youn Ju Na, Su Jung Baik, Hae Sun Jung, Ji Min Jung, Chang Yoon Ha, Seong-Eun Kim, Sung-Ae Jung, Sun Young Yi, Kwon Yoo, Kyu Won Chung, Joo-Ho Lee

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: CLINICAL / BILIARY T1695

Comparison Hilar Bile Duct Cancer with Intrahepatic Cholangiocarcinoma Involving the Hepatic Hilus Tsuyoshi Sano*, Kazuaki Shimada, Minoru Esaki, Yoshihiro Sakamoto, Tomoo Kosuge, Yasuhiro Shimizu, Yuji Nimura

T1696

Progress in Laparoscopic Surgery for Adult Choledochal Cysts-Kyushu University Experience Hiroki Toma*, Shuji Shimizu, Shunichi Takahata, Masafumi Nakamura, Eishi Nagai, Koji Yamaguchi, Masao Tanaka

T1697

Outcomes of Endoscopic and Surgical Management of Sphincter of Oddi Dyskinesia in Patients Not Responding to Cholecystectomy for Chronic Acalculous Cholecystitis James O. Johnson*, Kirpal Singh, Maurice E. Arregui

T1698

The Significance of CD44 Expression in Ampullary Cancer Hui-Ping Hsu*, Kai-Hsi Hsu, Yan-Shen Shan, Pin-Wen Lin

T1699

Asymptomatic Cholelithiasis Occurrence in Patients of Kidney Transplantation List André T. de Brito, André M. Siqueira, Luiz S. Azevedo, José Eduardo M. Cunha, José Jukemura*

T1700

Significance of Tissue Expression of MUC5AC in Hilar and Intrahepatic Cholangiocarcinoma Andrea Ruzzenente*, Calogero Iacono, Tommaso Campagnaro, Paola Capelli, Sara Mazzoldi, Alessandro Valdegamberi, Paola Nicoli, Alfredo Guglielmi

Denotes DDW Poster of Distinction

P-269

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y MAY 20

T1701

Preoperative Assessment of Intrahepatic Cholangiocarcinoma: CT Features with Pathological Correlation Riccardo Manfredi*, Sara Mehrabi, Marco Motton, Roberto Pozzi Mucelli, Andrea Ruzzenente, Paola Capelli, Calogero Iacono, Alfredo Guglielmi

T1713

Prospective Study On the Management of Acute Diverticulitis Pierpaolo Sileri*, Vito M. Stolfi, Paolo Gentileschi, Giuseppe S. Sica, Girolamo De Andreis, Alessandra Di Giorgio, Alberto Galante, Achille Lucio Gaspari

T1714

Incidence of Adhesional Small Bowel Obstruction (SBO) After Colorectal Surgery Pierpaolo Sileri*, Alessandra Mele, Vito Maria Stolfi, Nicola Di Lorenzo, Paolo Gentileschi, Giuseppe S. Sica, Achille Lucio Gaspari

T1715

Laparoscopic Appendectomy for Complicated Appendicitis Pierpaolo Sileri*, Paolo Gentileschi, Giuseppe S. Sica, Piero Rossi, Luana Franceschilli, Federico Perrone, Achille Lucio Gaspari

T1716

Small Intestinal Bacterial Overgrowth Is Common in Patients with Lower Gastrointestinal Symptoms and a History of Previous Abdominal Surgery Grant G. Sarkisyan*, Maura Fernandez, Eileen A. Coloma, Patrizio Petrone, Gabriel Akopian, Adrian E. Ortega, Howard S. Kaufman

T1717

Cytokine Network in Rectal Mucosa in Perianal Crohn's Disease: Relations with Inflammatory Parameters and Need for Surgery Cesare Ruffolo, Marco Scarpa, Diego Faggian, Anna Pozza, Filippo Navaglia, Renata D'Incà, Pravera Hoxha, Giovanna Romanato, Lino Polese, Giacomo C. Sturniolo, Mario Plebani, Davide F. D'Amico, Imerio Angriman*

Contemporary Surgical Management for Ileosigmoid Fistulas in Crohn's Disease Genevieve B. Melton*, Luca Stocchi, Elizabeth Wick, Kweku A. Appau, Victor W. Fazio

T1718

The Usage of Botulinum Toxin in the Treatment of Chronic Anal Fissures Alex J. Ky*, Randolph M. Steinhagen, Erin K. Ly, Emily Steinhagen

Abdominal Surgery Impact Scale (ASIS) Is Responsive in Assessing Outcome Following IPAA Indraneel Datta*, Brenda I. O'Connor, J Charles Victor, Robin S. McLeod

SSAT Poster Session 8:00 AM - 5:00 PM

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: CLINICAL / COLON-RECTAL T1702

Anastomotic Leaks After Bowel Resection: What Do We Learn from Peer Review? Neil H. Hyman*, Turner Osler, Peter Cataldo, Betsy Burns, Steven r. Shackford

T1703

Preoperative Assessment of Nutritional Status in the Patients with Ulcerative Colitis - Evaluation of Nutritional Markers Which Predict Septic Complications Ken-ichi Takahashi*, Tohru Asakura, Yuji Funayama, Kouhei Fukushima, Chikashi Shibata, Hitoshi Ogawa, Hiromi Tokumura, Iwao Sasaki

T1704

T1705

T1706

T1707

T1708

T1709

Morbidity and Mortality Associated with Emergency Abdominal Surgery in the Elderly Jill M. Zalieckas*, Patricia L. Roberts Is There a Critical Number of Recovered Nodes in YPT3-4 Rectal Cancer After Neoadjuvant CRT in Order to Provide Proper Final Disease Staging? Igor Proscurshim*, Rodrigo O. Perez, Angelita Habr-Gama, Guilherme São Julião, Joaquim Gama-Rodrigues, Fabio Campos, Viviane Rawet, Desiderio Kiss, Ivan Cecconello Is Initial Pre-Treatment Staging for Distal Rectal Cancer Undergoing Neoadjuvant CRT Useful? Angelita Habr-Gama, Rodrigo O. Perez*, Igor Proscurshim, Joaquim Gama-Rodrigues, Guilherme São Julião, Antonio R. Imperiale, Desiderio Kiss, Ivan Cecconello Are There Any “High Risk” Features in Stage II Rectal Cancer After Neoadjuvant CRT and Radical Surgery? Rodrigo O. Perez*, Igor Proscurshim, Guilherme São Julião, Angelita Habr-Gama, Joaquim Gama-Rodrigues, Antonio R. Imperiale, Fabio Campos, Desiderio Kiss, Ivan Cecconello

T1710

Does Laparoscopic Approach Affect the Number of Lymph Nodes Harvest in Colorectal Cancer? Galal S. El-Gazzaz*, Geisler P. Daniel, Tracy L. Hull

T1711

Risk of Leak After Laparoscopic Versus Open Bowel Anastomosis Galal S. El-Gazzaz*, Daniel P. Geisler, Tracy L. Hull

T1712

Postoperative Bowel Function After Lumber Colonic Nerve Preserving Low Anterior Resection for Rectal Cancer Yoshitaka Tanabe*, Hiroaki Matsunaga, Takashi Ueki, Shosaku Nakahara, Masao Tanaka

P-270

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: CLINICAL / ESOPHAGEAL T1719

Esophageal Adenocarcinoma Associated with Barrett's Esophagus: Survival Benefit? Valerie A. Williams*, Thomas J. Watson, Katherine A. Dudley, Svetlana Zhovtis, Carolyn E. Jones, Daniel Raymond, Jeffrey H. Peters

T1720

Changing Prognosis of Spontaneous Esophageal Perforation (Boerhaave Syndrome): A Personal Experience of 64 Cases in a Single Center Jarmo A. Salo*, Jari V. Räsänen, Eero I. Sihvo

T1721

The Value of Endoscopic Ultrasound to Distinguish the Number of Lymph Node Metastases in Patients with Esophageal Adenocarcinoma Jessica M. Leers*, Jeffrey A. Hagen, Shahin Ayazi, Arzu Oezcelik, Emmanuele Abate, Farzaneh Banki, John C. Lipham, Steven R. DeMeester, Tom R. DeMeester

T1722

Significant Pressure Differences Between Solid-State and Water Perfused Systems in Lower Esophageal Sphincter Measurement Heinz Wykypiel*, Ronald A. Hinder, Kenneth R. DeVault, Gerold J. Wetscher, Alexander Klaus, Paul J. Klingler

T1723

Understanding Laryngopharyngeal Reflux (LPR): The Prevalence of Anatomic Esophagogastric Junction Degradation in LPR Patients Kyle A. Perry*, Cedric S. Lorenzo, Paul H. Schipper, Joshua S. Schindler, Cynthia Morris, Blair A. Jobe

T1724

The Effect of Body Position On Hiatal Anatomy in Patients with GERD Kyle A. Perry*, Cedric S. Lorenzo, Paul H. Schipper, Joshua S. Schindler, Cynthia Morris, Blair A. Jobe

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL T1725

Better Reflux Control with a Nissen Fundoplication 10-Year Results After Laparoscopic Antireflux Surgery Martin Fein*, Marco Bueter, Andreas Thalheimer, KarlHermann Fuchs

T1726

Association of Pregnane X Receptor (PXR) with Esophageal Disease in An Irish Population Mahwash Babar*, John V. Reynolds, Ross McManus

T1727

T1737

Usefulness of 13C-Labeled Mixed Triglyceride Breath Test for Evaluating Exocrine Pancreatic Function After Pancreatic Surgery Hiroyuki Nakamura*, Yoshiaki Murakami, Kenichiro Uemura, Yasuo Hayashidani, Takeshi Sudo, Taijiro Sueda

T1738

Surgical Resection of Renal Cell Carcinoma Metastatic to the Pancreas Joshua G. Barton*, Jarrod R. Daniel, Andrew C. McCoy, Michael J. Levy, David Nagorney, Florencia G. Que, Michael B. Farnell, Michael L. Kendrick



The Influence of FDG-PET On the Decision to Operate for Esophageal Carcinoma Jason W. Smith*, Jonathan Moreira, Gerard Abood, Margo Shoup

T1739

T1728

Surgical Outcomes Following Laparoscopic Re-DO Heller Myotomy in the Treatment of Achalasia Matthew J. Schuchert*, James D. Luketich, Arman Kilic, Neil Christie, Miguel Alvelo-Rivera, Manisha Shende, Rodney J. Landreneau, ARJUN PENNATHUR

Pancreatic Acinar Cell Carcinoma: A Multi-Institutional Study Jesus M. Matos*, C. Max Schmidt, Marco Niedergethmann, Hans Detlev Saeger, Nipun Merchant, Keith D. Lillemoe, Robert Grützmann

T1740



Pancreatic Exocrine Function in Patients Undergoing Distal Pancreatectomy As Assessed By Human Stool Elastase-1 James E. Speicher*, L. William Traverso

T1741

Risk Factors for Pancreatic Leak Following Distal Pancreatectomy Hari Nathan*, Michael Choti, Christopher L. Wolfgang, C. Rory Goodwin, Akhil K. Seth, Jordan M. Winter, Barish H. Edil, Richard D. Schulick, Timothy M. Pawlik, John L. Cameron

T1742

Analysis of Organ Failure, Mortality and Pancreatic Necrosis in Patients with Severe Acute Pancreatitis Tercio De Campos*, Cinara Cerqueira, Laise Kuryura, Silvia Solda, Jacqueline Perlingeiro, Jose C. Assef, Samir Rasslan

T1743

Quality of Life in Long-Term Survivors After Pancreaticoduodenectomy Roberto Salvia, Stefano Crippa*, Francesca Mazzarella, Claudio Bassi, Stefano Partelli, Massimo Falconi, Giovanni Butturini, Paolo Pederzoli

T1744

Intraoperative Assessment of Margin Status At the Time of Pancreaticoduodenectomy Ensures R0 Resection in Patients with Pancreatic Cancer Robert Yates*, Kristian Wall, Peter Muscarella, E. Christopher Ellison, Mark Bloomston

T1745

Surgical Drainage of Symptomatic Peripancreatic Fluid Collections in the Era of Endoscopic Management Luis A. Benavente-Chenhalls*, Eduardo E. Montalvo-Jave, Michael B. Farnell, Michael G. Sarr, Todd H. Baron, Michael L. Kendrick

T1746

Estimation of Physiologic Ability and Surgical Stress (EPASS) As a Predictor of Immediate Outcome After Pancreatic Surgery: The Score Needs to Be Adapted! Simone Deyle, Markus Wagner, Katrin Becker, Daniel Inderbitzin, Beat Gloor*, Daniel Candinas

T1747

Is Adjuvant Therapy Indicated After Pancreatectomy for Adenocarcinoma? Jonathan M. Hernandez*, Daniel Molloy, Jennifer C. Cooper, Carl B. Bowers, Sarah Cowgill, Steven B. Goldin, Alexander S. Rosemurgy



SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: CLINICAL / HEPATIC T1729

Validation of the E-PASS Scoring System for Prediction of Mortality and Morbidity in Hepatic Resections Vanessa Banz*, Peter Studer, Regula Fankhauser, Beat Gloor, Daniel Inderbitzin, Daniel Candinas

T1730

Prolonged Survival in Selected Patients Following Metastasectomy from Hepatocellular Carcinoma Chen Fang Lee*, Miin-Fu Chen

T1731

Prognostic Factors After Liver Resection for Colorectal Metastases: Multivariate Analysis and Comparison with the FONG-Score Ulrich Adam*, Frank Makowiec, Hannes Neeff, Oliver G. Opitz, Eva Fischer, Ulrich T. Hopt

T1732

Ultrasound Guided Liver Resection: Does This Approach Limit the Need for Portal Vein Embolization? Guido Torzilli*, Matteo Donadon, Angela Palmisano, Matteo Marconi, Fabio Procopio, Florin Botea, Daniele Del Fabbro, Marco Montorsi

T1733

Surgical Management of Leiomyosarcoma of the Inferior Vena Cava in Eight Patients Sung W. Cho, James W. Marsh, David A. Geller, Jason Heckman, Shane Holloway, Matthew Holtzman, Herbert Zeh, David L. Bartlett, T Clark Gamblin*

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: CLINICAL / PANCREAS T1734

EUS-Guided Drainage of Peripancreatic Fluid Collections Following Distal Pancreatectomy Shyam Varadarajulu*, John D. Christein, Charles M. Wilcox

T1735

Management of Intraductal Papillary-Mucinous Neoplasms of the Pancreas (IPMN) - a 10-Years Experience in Two Pancreatic Centers in Germany Robert Grützmann*, Dag Dittert, Ralf Hildenbrand, Stefan Post, Hans Detlev Saeger, Marco Niedergethmann

T1736

Indication for Special Therapies in Acute Pancreatitis: Optimum Severity Score for Continuous Regional Arterial Infusion and Enteral Nutrition Takashi Ueda*, Yoshifumi Takeyama, Takeo Yasuda, Makoto Shinzeki, Hidehiro Sawa, Yonson Ku, Yoshikazu Kuroda, Harumasa Ohyanagi

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: CLINICAL / SMALL BOWEL T1748

Can Plain Abdominal X-Ray Predict the Need for Operation in Patients with Adhesive Small Bowel Obstruction? Nathan M. Novotny*, Daniel A. Liesen, Anthony Senagore, Thomas Z. Hayward, Don J. Selzer, Robert E. Pennington, Imtiaz A. Munshi, Nicholas J. Zyromski

Denotes DDW Poster of Distinction

P-271

T U E S D A Y MAY 20

POSTER SESSIONS—CLINICAL T U E S D A Y MAY 20

T1749

A Proposed Algorithm for Ventral Hernia Repair Optimizes Patient Outcome Judy Jin*, Christina P. Williams, Michael J. Rosen

T1750

Laparoscopic Roux-en-Y Gastric Bypass in 400 Consecutive Patients Without Internal Hernia Richard S. Flint*, Thien K. Nguyen, David B. Lautz

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: CLINICAL / STOMACH T1751

Surgical Therapy for Adenocarcinoma of the True Gastric Cardia Marcus Feith*, Hubert J. Stein

T1752

Surgical Technique Affects the Incidence of Marginal Ulceration After Roux-en-Y Gastric Bypass Yong-Kwon Lee*, Jon S. Thompson, Valerie Shostrom, Corrigan L. McBride

T1753

Results of Uncut Roux-En Y Reconstruction After Distal Gastrectomy for Gastric Cancer Chikashi Shibata*, Terutada Kobayashi, Tatsuya Ueno, Masayuki Kakyou, Makoto Kinouchi, Kouhei Fukushima, Iwao Sasaki

T1754

Changes in Inflammatory Biomarkers Across Weight Classes in a Representative US Population: A Link Between Obesity and Inflammation Xuan-Mai T. Nguyen*, Marcelo W. Hinojosa, Brian R. Smith, Ninh T. Nguyen

T1755

Order of Placement Does Not Change Complication Rates for Patients with Concomitant Ventriculoperitoneal Shunt and Percutaneous Endoscopic Gastrostomy Nora C. Meenaghan*, Elizabeth Franco, Adrian E. Park, J. Scott Roth

T1757

The Influence of Anastomotic Line Tumor Invasion and Mesenterial Lymph Node Metastases in Survival of Patients with Gastric Stump Cancer Claudio Bresciani*, Ana L. Carrasco, Rodrigo O. Perez, Carlos E. Jacob, Joaquim Gama-Rodrigues, Bruno Zilberstein, Ivan Cecconello

T1758

Duodenal Bypass in Lean Individuals Do Not Decrease Glucose Levels Ana C. Tineli*, Fernando A. Herbella, Jorge L. Wilson, Jose C. Del Grande

T1759

Use of Polypropylene Mesh for Laparoscopic Adjustable Gastric Banding (LAGB) Allows for Minimum Post-Op Pain with No Narcotic Usage and Less Pain for Adjustments Carson D. Liu, Leonierose Dacuycuy*

P-272

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC BASIC AASLD Poster Session 8:00 AM - 5:00 PM

T1761

Adenosine Inhibits Hepatocyte Growth Factor Induced Chemotaxis in Mesenchymal Stem Cells Mehdi Mohamadnejad*, Muhammad A. Sohail, Eugene S. Swenson, Wajahat Z. Mehal

T1774

Production of C- Peptide and Pancreatic Gene Expression Analysis in Human Fetal Liver Progenitor Cells Chittor M. Habibullah*, Md. Aejaz Habeeb, Aleem A. Khan, Parveen Nyamath, Mehboob Vali, Rajendra Prasad

Sails Pavilion San Diego Convention Center

CELL AND MOLECULAR BIOLOGY, STEM CELLS BIOLOGY AND GENE EXPRESSION T1760

T1773

Translocation of the Wilson Disease Protein Atp7b Is Independent of Rab7 and Murr1/ Commd1 Karl Heinz Weiss*, Javier Carbajo Lozoya, Sabine Tuma, Daniel Gotthardt, Jürgen Reichert, Robert Ehehalt, Wolfgang Stremmel, Joachim Fuellekrug Hrp12, the Murine Member of the Highly Conserved But Enigmatic Yer057c/Yjgf/Uk114 Family, Interacts with Mitochondrial and Secreted Liver Proteins in the YeastBased Two-Hybrid System Sam J. Samuel*, Alia A. Alawneh, Michael D. Sitrin

AASLD Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

CELL DEATH AND EXPERIMENTAL HEPATOTOXICITY T1775

Azoxymethane Induces Chronic Liver Injury in Mice: A New Model of Experimental Cirrhosis and Ductular Proliferation Nirish Shah*, Roxana Samimi, Kunrong Cheng, Cinthia Drachenberg, Jean-Pierre Raufman, Sandeep Khurana

T1762

Numb Is Involved in Regulation of Hepatic Self-Repair By Antagonizing Notch, Wnt and Hedgehog Pathway Hiroshi Nagata*, Miho Adachi, Toshifumi Hibi

T1763

A Keratin 8 Single Glutamine “Switch” Is Essential for Its Crosslinking By Transglutaminase-2 and Inclusion Body Formation Raymond Kwan*, Pavel Strnad, Shinichiro Hanada, Bishr Omary

T1776

Mao (Ephedra Sinica Stapf) Prevents Fulminant Liver Failure Resulting in Reduction of Lethality Through the Suppression of Hepatocytes Apoptosis Ikuhiro Yamada*, Takashi Goto, Satoko Takeuchi, Shigetoshi Ohshima, Hirohide Ohnishi

T1764

The Genetic Background Plays An Important Role in Mouse Hepatocyte Mallory-Denk Body Formation Shinichiro Hanada*, Pavel Strnad, Elizabeth M. Brunt, Bishr Omary

T1777

T1765

The Enhancement of Peroxisome Proliferator-Activated Receptor-Gamma Activity By Curcumin Blocks the Signaling Pathways for Platelet Derived Growth Factor and Epidermal Growth Factor in Activated Hepatic Satellite Cell In Vitro Jianguo Lin*, Anping Chen

Activation of PPAR β/δ Reduces Copper-Dependant Oxidative Stress and Fasl (Cd95l) Mediated Apoptosis in HEPG2 Cells: Possible Implications in Clinical Practice Alvaro A. Sanchez-Siles*, Norihisa Ishimura, Md. M. Aziz, Yoshiyuki Mishima, Shunji Ishihara, Yoshikazu Kinoshita

T1778



Mcl-1 - a Critical Factor for the Survival of Hepatocytes Binje Vick, Achim Weber, Toni Urbanik, Peter R. Galle, Henning Schulze-Bergkamen*

Defective Antioxidant Response, Increased Oxidative Stress and Increased Liver Injury in a Cyp 2e1 Transgenic Mouse Model of Steatohepatitis Philip T. Chen*, Elango Kathirvel, Kengathevy Morgan, Samuel W. French, Timothy R. Morgan

T1780

T1767

Molecular Basis On the Phathogenesis of Liver Cirrhosis and Biliary Carcinoma Infected with Helicobacter pylori Momoyo Asahi

Peroxisome Proliferator-Activated Receptor Agonist Effects On Alcohol-Induced Hepatic Insulin Resistance Maoyin Pang*, Suzanne M. de la Monte, Rajeeve Chaudhry, Kevin Duan, Jiyun Ouh, Jade Carter, Jack R. Wands

T1781

T1768



IFNγ Down-Regulates Endothelin-1 Expression Via a Stat1 Independent Pathway Tianxia Li*, Zengdun Shi, Don C. Rockey

N-Acetyl-L-Cysteine (NAC) Abrogates Changes in Cell Viability, Mitochondrial Potential and Gene Expression Caused By (-)-Epigallocatechin Gallate (EGCG) in a Human Liver (Huh7) Cell Line Michael J. Grupka*, Richard W. Lambrecht, Petr Protiva

T1769

Fip200, a Novel Tumor Suppressor Protein, Suppresses Cell Cycle Progression Through p53 in Hepatocellular Carcinoma HIROKI UEDA*, Masakazu Ichinose

T1782

T1770



Mitochondrial DNA Mutations May Shed Light On Clonal Expansion in Human Liver Tissue Tariq G. Fellous*, Stuart A. McDonald, Nicholas A. Wright

Lipopolysaccharide Binding Protein (Lbp) Inhibitory Peptide Attenuates Acetaminophen Induced Hepatotoxicity Grace L. Su*, Laszlo M. Hoesel, Aladdein Mattar, Mark R. Hemmila, Stewart C. Wang

T1783

T1771

The Effects of Extracellular Matrices and Growth Factors On Hepatic Lineage Differentiation of Human Embryonic Stem Cells Ken Fukumitsu*, Takamichi Ishii, Kentarou Yasuchika, Keiko Adachi, Hirofumi Suemori, Norio Nakatsuji, Iwao Ikai, Shinji Uemoto

The Functional UDP-Glucoronosyltransferase (UGT) 1a1 Promoter Polymorphism May Increase the Risk of AntiTuberculosis Drug-Induced Hyperbilirubinemia Yi-Shin Huang

T1784

Variability in the Upper Limit of ALT Among Different Clinical Laboratories in Indiana: A State-Wide Survey Anand Dutta*, Naga P. Chalasani

T1785

Nonsteroidal Anti-Inflammatory Drug-Related Acute Liver Failure: A Rare But Serious Adverse Effect Alice L. Yang*, Shweta Vadhavkar, Aijaz Ahmed, Ramsey C. Cheung, George Triadafilopoulos, Bishr Omary, Gurkirpal Singh

T1766

T1772

Differentiation of Mouse Hepatic Progenitor Cells Induced By Hepatocyte Nuclear Factor-4 and Effect of Cell Transplantation in Mice with Liver Cirrhosis Atsushi Suetsugu*, Masahito Nagaki, Yoshihiko Tsukada, Yosuke Osawa, Hisataka Moriwaki

Denotes DDW Poster of Distinction

P-273

T U E S D A Y MAY 20

POSTER SESSIONS—BASIC T U E S D A Y

T1786

Safety of Thiazolidinediones (TZDs), Metformin, and/or Statin Therapy in Patients with Chronic Hepatitis C (HCV) Infection Hyosun H. Han*, Andrew S. Boxer, Michael E. Adler, Jeremy L. Matloff, Damaris Carriero, Douglas T. Dieterich

T1787

Predictors and Prognosis of Renal Injury in Acute Acetaminophen Overdose with and Without Liver Injury Emely F. Eid, Matthew Dollins, Beth E. Juliar, Marc B. Rosenman, Mazen Alsatie, Naga P. Chalasani, Marco A. Lacerda, Suthat Liangpunsakul, Vijay Laxmi Misra, Rakish Vinayek, Raj Vuppalanchi, Paul Kwo*

MAY 20 T1788 T1789

Prevention of Drug-Induced Liver Toxicity Joel E. Bernstein*, David A. Henninger, Scott B. Phillips

T1797

Helicobacter pylori vacA I-Region Genotype Is Associated with An Increased Risk of Gastric Cancer, Vacuolating Cytotoxin Activity, and cagA Status in Okinawa, Japan Yoshiyuki Ito*, Tomoko Inagaki, Akiyo Yamakawa, Satoko Satomi, Hidetaka Matsuda, Takashi Ohno, Ryuho Masaki, Masahiro Ohtani, Soshoku Lee, Hiroyuki Suto, Yukinao Yamazaki, Yoshihide Keida

T1798

Discovery of Proteome Biomarkers Discriminating the Pathogenicity of Helicobacter pylori Ki-Baik Hahm*, Heajin Sim, So Yeon Yoo, Tae Won Kim, Sang Jong Park, Hyun W. Baik, Eun Jung Jang, Joo Sang Park

T1799

Genotypic and Phenotypic Profiling of Helicobacter pylori (HP) Strains from Symptomatic North American Children Reveals High Prevalence of Strains Lacking Adult HP Virulence Markers But Strong Association of cag PAI and Ulcer Disease Nina R. Salama*, Sarah Talarico, Jutta Fero, Dexter T. Thompson, Steven Czinn, Benjamin D. Gold

T1800

Molecular Analysis of Stomach Microbial Diversity in Non-Helicobacter pylori Gastritis and Normal Patients Chunming Ding*, Xiaoxing Li, Grace Wong, Larry H Lai, Joseph J. Sung

T1801

Helicobacter pylori cagA EPIYA C Tyrosine Phosphorylation Motif Influences the Risk for Gastric Carcinoma Development Rui M. Ferreira, Jose C. Machado, Fatima Carneiro, Ceu Figueiredo*

T1802

Genotyping of vacA and cagA from Helicobacter pylori Isolates in Alaska Julie Morris*, Karen Miernyk, Michael Bruce, Dana L. Bruden, Brian J. McMahon, Debby Hurlburt, Alan Parkinson

T1803

The Possible Involvement of Protease-Activated Receptors (PAR) in H. pylori-Associated Gastritis Ikuhiro Hirata*, Norimasa Yoshida, Tatsushi Omatsu, Tetsuya Okayama, Takahiro Suzuki, Hirokazu Kajikawa, Katsura Mizushima, Toshikazu Yoshikawa

T1804

Novel 13C-Urea Breath Test Chamber for Gerbils Antone R. Opekun*, Tomoyuki Ohno, David Y. Graham, Yoshio Yamaoka

Oral Medications with Extensive Hepatic Metabolism May Have Higher Risk of Idiosyncratic Drug Induced Liver Injury (DILI) Craig Lammert*, Anna Niklasson, Einar Bjornsson, Naga P. Chalasani

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

H. PYLORI: BACTERIAL FACTORS Participants will be able to: • Understand relevant bacterial factors involved in Helicobacter pylori virulence. T1790



Helicobacter pylori cag Pathogenicity Island Genes cagE, cagM and cagA Are Necessary for Gastric H,K-ATPase α Subunit Gene Repression Arindam Saha*, Charles E. Hammond, Richard M. Peek, Adam J. Smolka

T1791



Factors Which Affect Susceptibility of Suckling Mice to Helicobacter pylori Hiroyuki Suto*, Masahiro Ohtani, Yoshiyuki Ito, Yukinao Yamazaki, Takeshi Azuma, Douglas Berg

T1792



Impact of Helicobacter Infection in Mice Liver Kyoko Ito*, Mariko Nakamura, Gotaro Toda, Tsuneya Ohno, Tomokazu Matsuura, Hisao Tajiri

T1793

Identification of Disease Specific Helicobacter pylori cagY Antibody By Phage Display Method Akiyo Yamakawa*, Kiyonori Katsuragi, Yoshiyuki Ito, Hiroyuki Suto, Masahiro Ohtani, Ikumi Yoshida, Suguru Akamatsu, Takeshi Azuma, Yukinao Yamazaki

AGA Institute Poster Session 8:00 AM - 5:00 PM



Effect of Long Term H. pylori Colonization and a Chemical Carcinogen On Bacterial Genetic Diversity During a 5-Year Experimental Study in Rhesus Monkeys Andre Dubois*, Jutta Fero, Arifur Rahman, Hui Liu, Cristina Semino-Mora, Nina R. Salama, Richard M. Peek

H. PYLORI: IMMUNE RESPONSE

T1795

Adaptation of Carnivore-Colonizing Helicobacter Species to the Diet of Their Host Jeroen Stoof, Simone Breijer, Raymond G. Pot, Johannes G. Kusters, Arnoud H. Van Vliet, Ernst J. Kuipers*

T1805



Downregulation of Muscle-Specific MicroRNAs in the Stomach of Helicobacter pylori Infected Mice Yoshimasa Saito*, Hidekazu Suzuki, Hitoshi Tsugawa, Etsuko Sugai, Toshifumi Hibi

T1796

Helicobacter pylori cag+ Strains Selectively Induce Epithelial Secretion of Eosinophil Chemoattractants Shannon S. Allen*, Lydia E. Wroblewski, M. Blanca Piazuelo, Alberto Delgado, Pelayo Correa, Richard M. Peek

T1806

Depletion of CD25+ Regulatory T Cells Enhances the In Vivo Priming of the H. pylori-Specific TH1 Response By Conventional Dendritic Cells Min Zhang, Bradford E. Berndt, Sivaprakash Rathinavelu, John Y. Kao*

T1794

P-274

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

Participants will be able to: • Understand recent basic research of immune responses and vaccines targeting Helicobacter pylori.



Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC T1807



A Single Nucleotide Polymorphism in the TLR9 Promoter (TLR9 -1237T/C) Increases the Affinity of NFκB Protein Binding and Enhances Transcriptional Activity Upon H. pylori Infection Mike T. Ng*, Julie C. Crockett, Rob Van't Hof, Susan H. Berry, Emad El-Omar, Georgina Hold

T1808



Helicobacter pylori Alters Gastric Epithelial Tight Junctions in a Myosin Light Chain Kinase-Dependent Manner Lydia E. Wroblewski*, Le Shen, Toni Nagy, Seth R. Ogden, Shannon S. Allen, Jerrold R. Turner, Richard M. Peek

T1809

The Novel Anti-Inflammatory Apoe-Mimetic Peptide COG112 Inhibits Helicobacter pylori-Stimulated Interleukin-8 Expression in Gastric Epithelial Cells Stephanie M. Cauble*, Mohammad Asim, Rupesh Chaturvedi, Daniel P. Barry, Nuruddeen D. Lewis, Kshipra Singh, Michael P. Vitek, Keith T. Wilson



T1810

T1811

T1812

NOD1 Upregulate Expression of IL-8 Through NF-κB Activation in Human Epithelial Cells Infected with Helicobacter pylori Jae G. Kim*, Bum Joon Park, Su Yeon Rhie, Ki Sung Kim, Sill Moo Park Anti-Inflammatory Effect of Interleukin-17 On Helicobacter pylori-Induced Gastritis Koji Otani*, Toshio Watanabe, Hiroshi Tatsuwaki, Tetsuya Tanigawa, Hirotoshi Okazaki, Hirohisa Machida, Hirokazu Yamagami, Kenji Watanabe, Kazunari Tominaga, Yasuhiro Fujiwara, Nobuhide Oshitani, Tetsuo Arakawa cagA-Positive Strains of H. pylori Affect Trophoblast Cells Invasiveness: Do They Play a Role in PreEclampsia and Poliabortivity? Francesco Franceschi*, Giovanni Gigante, Nicoletta Di Simone, Davide Roccarina, Maria Chiara D'Alessio, Marco Marini, Bianca Giupponi, Floriana Mancini, Guido De Marco, Federico Barbaro, Valentina Fiore, Roberta Castellani, Giovanni Gasbarrini, Antonio Gasbarrini, Alessandro Caruso, Nicolò Gentiloni Silveri

AGA Institute Poster Session 8:00 AM - 5:00 PM

T1817

AGA Institute Poster Session 8:00 AM - 5:00 PM

TISSUE REPAIR, ADAPTATION AND APOPTOSIS IN GROWTH, DEVELOPMENT AND DISEASE Participants will be able to: • Learn more about tissue repair, adaptation and apoptosis in growth, development and disease. T1818

Early Administration of Glucagon-Like Peptide-2 (GLP2) Following Ileocecal Resection Augments Insulin-Like Growth Factor-I (IGF-I) Signaling During Intestinal Stem Cell Expansion Aaron P. Garrison*, Christopher M. Dekaney, Doug C. von Allmen, P. Kay Lund, Susan J. Henning, Michael A. Helmrath

T1819



Tyrosine Phosphatase of Liver Regeneration-1 (PRL-1) Is Required for Hepatocyte Proliferation During Liver Regeneration Diana Ye*, Klaus H. Kaestner

T1820

Enteric Glial Cells Promote Wound Healing of Intestinal Epithelial Barrier in Part Via a FAK-Dependent Pathway Laurianne Van Landeghem*, Pascal Derkinderen, Philippe Aubert, Hervé Enslen, Isabelle Guisle-Marsollier, Jean Léger, Jean Paul Galmiche, Tor Savidge, Michel Neunlist

T1821

Liver-Derived Microparticles Carry Biologically-Active Hedgehog Morphogens in Blood and Bile Rafal P. Witek*, Renshui Liu, Liu Yang, Youngmi Jung, Kevin Brown, Alessia Omenetti, Mercedes VazquezChantada, Wing-Kin Syn, Steve S. Choi, Jiawen Huang, Wei Chen, Anna Mae Diehl

T1822

Deletion of Epimorphin Alters Colonic Myofibroblast Function and Affects Colonic Epithelial Proliferation Anisa Shaker*, Elzbieta A. Swietlicki, Lihua Wang, Shujun Jiang, Qiuling Wang, Christopher Rowley, Carrie C. Coughlin, Marc S. Levin, Deborah C. Rubin

T1823

Regulation of Intestinal Autophagy By Epidermal Growth Factor in An Experimental Model of Necrotizing Enterocolitis Bohuslav Dvorak*, Ludmila Khailova, Kelly M. Arganbright, Charity A. Reynolds, Melissa Halpern, Katerina Dvorak

T1824

Loss of the Pericryptal Myofibroblasts in Crohn's Disease: A Consequence of TNFα and IFNγ Synergy Caroline Francoeur, Elizabeth Herring, Pierre H. Vachon, Jean-Francois Beaulieu*

T1825

H. pylori and Ageing Kyoko Ito*, Suhaib Abudayyeh, Fazal H. Tabassam, David Y. Graham, Hala El-Zimaity

T1826

Intestinal Cell Kinase Regulates Proliferation of Intestinal Epithelial Cells Zheng Fu*, Alda Vidrich, Thomas W. Sturgill, Steven M. Cohn

Sponsored by: Growth, Development & Aging

MUCOSAL GROWTH FACTORS AND CELL SIGNALING IN GROWTH AND DEVELOPMENT

T1813



Activation of Cdk2 Stimulates Proteasome-Dependent Truncation of the Tyrosine Phosphatase SHP-1 in Human Proliferating Intestinal Epithelial Cells Mélanie Simoneau, Jim Boulanger, Nathalie Rivard*

T1814

ERK-Dependent Phosphorylation Regulates E2f4 Nuclear Localization in Human Intestinal Crypt Cells Marie-Christine Paquin, Nathalie Rivard*

T1815

T1816

P2X7 Receptor Signalling in the Differentiation of Intestinal Epithelial Cells Karine L'Ériger, Christine Langlois, Fernand-Pierre Gendron* ERK1/2, But Not p38-MAP Kinase and JNK1/2, Play a Role in the Mechanism of EGF-Mediated Protection of Tight Junctions (TJS) from Acetaldehyde Geetha Samak*, Radhakrishna (RK) Rao

Sails Pavilion San Diego Convention Center

Sponsored by: Growth, Development & Aging

Sails Pavilion San Diego Convention Center

Participants will be able to: • Evaluate recent basic research on mucosal growth factors, cell signaling in growth and development.

Implication of PLCγ and PKC in the Mechanism of Epidermal Growth Factor (EGF) Protection Against Hydrogen Peroxide and TNFα-Induced Disruption of Tight Junctions (TJS) in Bile Duct Epithelium Srikar Guntaka*, Ankur Seth, Nicholas F. LaRusso, Radhakrishna (RK) Rao

Denotes DDW Poster of Distinction

P-275

T U E S D A Y MAY 20

POSTER SESSIONS—BASIC T U E S D A Y MAY 20

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

HORMONES & RECEPTORS IN GASTROINTESTINAL SECRETION

HORMONES & RECEPTORS IN VISCERAL HYPERSENSITIVITY

Participants will be able to: • Learn how hormones and receptors regulate gastrointestinal secretion.

Participants will be able to: • Understand the development of visceral hypersensitivity in relation to hormones & receptors.

T1827

Deficiency in the Gastrointestinal Hormone VIP Results in Gastric Atrophy and Hypochlorhydria As Determined in a Knockout Mouse Model Yuxin Lu*, David Oh, Gordon V. Ohning, John Vu, Patrizia M. Germano, James Waschek, Joseph R. Pisegna

T1835



T1828



Gastric miRNA Expression Profiling and Changes During Intestinal Metaplasia Following Achlorhydria Due to Lack of Gastrin or By Caused By Helicobactor Pylori Infection Lennart Friis-Hansen*, Ewa Futoma, Mikkel Klausen

1-Methylnicotinamide Accelerates Gastric Ulcer Healing Via An Activation of Cyclooxygenase (COX)-2/ Prostacyclin System and Sensory Nerves Tomasz Brzozowski*, Peter C. Konturek, Michal Pawlik, Slawomir Kwiecien, Robert Pajdo, Stefan Chlopicki, Jerzy Gebicki, Stanislaw Konturek, Wieslaw W. Pawlik

T1836



T1829

Vesicular Pool of Sodium Hydrogen Exchanger NHE4 in Rat Stomach Plays a Role in Acid Secretion Michael Brandstetter*, Maha Elsayed, Jama Nateqi, John P. Geibel

Gabapentin Reverses Colorectal Distension-Induced Visceral Pain Behaviours in Rat Models of Acute and Chronic Visceral Hypersensitivity Anne-Marie Coelho*, Siobhain M. O'Mahony, Colleen M. Taylor, Alan Wheeldon, Patrick Fitzgerald, Timothy G. Dinan, John F. Cryan, Kevin Lee, Wendy J. Winchester

T1837

Functional Role of Sodium Hydrogen Exchanger Nhe4 in Rat Stomach Jama Nateqi*, Michael Brandstetter, Maha Elsayed, Camila N. Bezerra, Nancy M. Reboucas, John P. Geibel

The Involvement of Estrogen and NMDA Receptor NR2B in Stress Induced Colorectal Hypersensitivity in Female Rats Junkai Su, Jun Gao*, Duowu Zou, Hailian Cao, Yu Bai, Zhaoshen Li

T1838

5-HT3 Receptor in the Submucousal Plexus Mediates Inhibition of Serotonin-Induced Secretion in Rat Distal Colon Ning Yang*, Hong Xue, Yue-min Tian, Xiao-Hui Zhang, LiFei Zheng, Xin Chen, Jin-xia Zhu

Analgesic Effects of 5-HT2B Antagonists in Pre-Clinical Models of Colorectal Pain David C. Bulmer*, Siobhain M. O'Mahony, Anne-Marie Coelho, Karen Gray, Colleen M. Taylor, Timothy G. Dinan, John F. Cryan, Kevin Lee, Wendy J. Winchester

T1839

Role of Steroid Receptor-Mediated Mechanisms in the Amygdala On Colonic Hypersensitivity in a High Anxiety Rat Anthony C. Johnson*, Kristen M. Campbell-Dittmeyer, Beverley Greenwood-Van Meerveld

T1830

T1831

T1832

Cellular Localization and Stimulation Dependent Distribution of Munc-18b in Gastric Parietal Cells Serhan Karvar*, Jo Suda, Lixin Zhu

T1833

Diffuse Gastric Mucosa Lesions Produced to Patients with Diabetes Insipidus After Desmopressin Administration. Mechanism of Action Ioan Puscas*, Andrei Todea, Sanda Stanca, Gabriela Domuta, Marcela Coltau, Lucian Unita, Lorena Indries, Daniela Cordea, Cosmin Teusdea

T1834

P-276

Bile Acids Stimulate Glucagon Like Peptide- 2 Secretion from L-Cells; Possible Mediation Through Membrane Receptor TGR5 Katharina Wallis*, Helen E. Parker, Carel W. Le Roux, Mohammad A. Ghatei, Alastair Forbes, Simon M. Gabe, Fiona Gribble, Julian R. Walters

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

HORMONES & RECEPTORS: EPITHELIAL CELL GROWTH AND PROLIFERATION Participants will be able to: • Understand mechanisms governing epithelial cell growth and proliferation. T1840



Histamine Induces Sonic Hedgehog Secretion Across the Apical Membrane of Polarized Parietal Cells Yana Zavros

T1841

Loss of Sonic Hedgehog Secretion Results in Disruption of Tight Junction Proteins and Development of Gastric Hyperplasia Yana Zavros

T1842

Wnt Blockade During Post-Natal Growth of the Small Intestine Preferentially Reduces Crypt Hyperplasia and Not Crypt Fission Jane K. Fauser*, Gordon S. Howarth, Ross N. Butler, Adrian G. Cummins

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC T1843

Fructose-Induced Translocation of the Glucocorticoid Receptor in Developing Rat Small Intestine Summer Elshenawy*, Veronique Douard, David Lagunoff, Ronaldo Ferraris

T1844

Flow Cytometric Detection of Progastrin Interaction with Gastrointestinal Cells Alexander N. Dubeykovskiy*, Thomas Thong H. Nguyen, Shi Lei, Timothy C. Wang

T1845



Calcineurin-NFAT Pathway Is a Critical Determinant of Adult Pancreatic Growth Plasticity Grzegorz T. Gurda*, John A. Williams

T1846

ERBB-4 Promotes Intestinal Cell Survival in Response to Tumor Necrosis Factor Mark R. Frey*, Karen L. Edelblum, Dongchun Liang, D. Brent Polk

T1847

FGF Ameliorates Radiation Injury in the Small Bowel Kunzhong Zhang, Anju T. Nayar, Hengshan Zhang, Paul Okunieff, Lurong Zhang, Sadasivan Vidyasagar*

T1848

Measurement of Non-Neuronal Acetylcholine Release By a Colon Cancer Cell Line Kunrong Cheng*, Roxana Samimi, Guofeng Xie, Cinthia Drachenberg, Mark R. Wade, George G. Nomikos, JeanPierre Raufman

AGA Institute Poster Session 8:00 AM - 5:00 PM

T1855

Molecular Imaging in Mouse Colon Tumors with Protease-Activatable Probe for Early Tumor Detection Soon Man Yoon*, Seung-Jae Myung, Hyun Mi Kim, Yeon Mi Ryu, Kyeongsoon Park, Kwangmeyung Kim, Ick Chan Kwon, Young Soo Park, Dae Hyuk Moon, Do Hoon Kim, Mi Young Do, Byong Duk Ye, Jeong-Sik Byeon, Suk-Kyun Yang, Jin-Ho Kim

T1856

Phospho-HSP20 Inhibits Translocation of PKCα Into the Caveolae: Real Time Monitoring of Movement of PKCα and Caveolin-1 in Human Colonic Circular Smooth Muscle Sita Somara*, Robert R. Gilmont, Paul M. Jenkins, Jeffrey R. Martens, Khalil N. Bitar

T1857

Morphological Versus Functional Imaging to Detect Recurrences After Resection of Liver Metastases of Digestive Endocrine Tumors (Lmdet) S. Scigliano*, Frédérique Maire, Jean Louis Stievenart, R. Lebtahi, Reza Kianmanesh, Alain Sauvanet, Marie-Pierre Vullierme, Anne Couvelard, Pascal Hammel, Jacques Belghiti, Philippe B. Ruszniewski, Dominique Le Guludec

T1858



Clostridium difficile Detection in Stool with a Nanoscale Microfluidic Device Sara Gillers*, Christopher D. Atkinson, Catherine Klapperich, Satish K. Singh

T1859

Cysteine-Cathepsin Activity Reveals Dynamics of Polyp Growth Elias Gounaris*, Fotini Gounari, Ching-Hsuan Tung, Ralph Weissleder, Khashayarsha Khazaie

T1860

Magnetic Resonance Enteroclysis in the Diagnosis of Small Bowel Neoplasms: A Retrospective Evaluation of 91 Studies Stijn J. Van Weyenberg*, Mike E. Craanen, Maarten A. Jacobs, Donald L. Van der Peet, Cornelis Van Kuijk, Chris J. Mulder, Jan Hein Van Waesberghe

T1861

Beyond the Barostat: Minimally Invasive Assessment of Gastric Volume and Pressure By Combined Magnetic Resonance Imaging and Fiber-Optic Pressure Recording System Mark R. Fox*, Andreas Steingoetter, Monika A. Kwiatek, Reto Treier, Peter Boesiger, Michael Fried, Werner Schwizer

T1862

Association Between Brain Activation and Symptom Response to Treatment in Patients with Irritable Bowel Syndrome (IBS): A Functional MRI (FMRI) Study Winnie C. Chu*, Justin Wu, Ka-Man C. Yim, Yawen Chan, Sau Fong E. Lee, Bing-yee Suen, Wai K. Leung, Joseph J. Sung

T1863

Magnetic Resonance Enteroclysis in the Diagnosis of Complicated Celiac Disease Stijn J. Van Weyenberg*, Abdulbaqi Al-Toma, Maarten A. Jacobs, Cornelis Van Kuijk, Chris J. Mulder, Jan Hein Van Waesberghe

T1864

MRI Findings of the Pelvic Floor Correlates with Function Kumaran Thiruppathy*, Stuart A. Taylor, Dave R. Chatoor, Richard Cohen, Anton V. Emmanuel

T1865

Virtual MR-Cholangiopancreatoscopy(V-Mrcps) By a Combination of High-Resolution(Hr) Data Acquisition and Interactive Visualization Tetsuya Yamagishi*, Takashi Kawai

T1866

Factors Predictive of Early Neoplasia in Barrett's Lesions Identified with Autofluorescence Imaging: A Stepwise Multi-Centre Structured Assessment Wouter L. Curvers*, Rajvinder Singh, Michael B. Wallace, Louis-Michel Wong Kee Song, Krish Ragunath, Herbert C. Wolfsen, Fiebo J. ten Kate, Paul Fockens, Jacques J. Bergman

Sails Pavilion San Diego Convention Center

Sponsored by: Imaging & Advanced Technology

SPECTROSCOPY AND FLUORESCENCE/ MOLECULAR IMAGING Participants will be able to: • Evaluate research in spectroscopy and fluorescence and molecular imaging. T1849

Optical Sentinel Node Biopsy for Gastric Cancer with Fluorescent Tracer and Cancer-Specific Monoclonal Antibody In Vivo Makoto Mitsunaga*, Akihito Tsubota, Koichi Nariai, Tomoki Koyama, Kiyotaka Fujise, Hisao Tajiri, Hiroshi Takahashi

T1850



Elastic Scattering Spectroscopy (Ess) Guided Forceps for the Diagnosis of Inflammatory Bowel Disease (IBD) Yakov Gitin*, Francis A. Farraye, Christopher D. Atkinson, Eladio Rodriguez-Diaz, Sandra Cerda, Michael J. O'Brien, Irving J. Bigio, Satish K. Singh

T1851

Near-Infrared Raman Spectroscopy for Early Diagnosis of Helicobacter pylori-Associated Chronic Gastritis Seng Khoon Teh, Wei Zheng, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Zhiwei Huang*

T1852

Elastic Scattering Spectroscopy (Ess)-Guided Snares for Real-Time Endoscopic Diagnosis and Removal of Colonic Polyps Christopher D. Atkinson*, Rayhme Collins, Eladio Rodriguez-Diaz, Sara Gillers, Yakov Gitin, Roberto Reif, Irving J. Bigio, Satish K. Singh



T1853

T1854



Morphological Feature Quantification of Colonic Crypt Patterns Using Microscope-Integrated OCT Xin Qi*, Yinsheng Pan, Zhilin Hu, Michael V. Sivak, Joseph Willis, Kayode Olowe, Andrew M. Rollins Intracellular Compartment-Specific Detection of H2O2 in Liver Cells Using a Fluorescent Fusion Protein Gunda Millonig*, Hongnian Guo, Helmut Karl Seitz, Sebastian Mueller

Denotes DDW Poster of Distinction

P-277

T U E S D A Y MAY 20

POSTER SESSIONS—BASIC T U E S D A Y

T1867

Diagnosis of Inflammatory Bowel Disease (IBD) Using An Analytical Model of Elastic Scattering Spectroscopy (Ess)-Guided Optical Biopsies Roberto Reif*, Eladio Rodriguez-Diaz, Yakov Gitin, Francis A. Farraye, Christopher D. Atkinson, Sandra Cerda, Irving J. Bigio, Michael J. O'Brien, Satish K. Singh

T1868

Is Magnetic Resonance Imaging (MRI) Accurate to Evaluate Small Bowel Crohn's Disease (CD)? Comparison with Pathologic Analysis of Surgical Specimen Carmen Stefanescu, Magaly Zappa, Dominique CazalsHatem, Frédéric Bretagnol, Yves Panis, Valérie Vilgrain, Yoram Bouhnik, Alain Attar*

MAY 20

T1869

Identification of Abdominal Adhesions By Dynamic Image Registration Benjamin P. Wright*, John W. Fenner, Richard Gillott, Patricia V. Lawford, Paul Spencer, Karna Dev Bardhan

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Intestinal Disorders

INTESTINAL TRANSPORT: ABSORPTION AND SECRETION Participants will be able to: • Evaluate absorption and secretion in intestinal transport. T1870



Brush Border Membrane Na:H Exchange Regulates NaGlucose Co-Transport in Intestinal Epithelial Cells Ramesh Kekuda*, Steven Coon, Prosenjit Saha, Jamilur R. Talukder, Uma Sundaram

T1871



Differential Roles of Slc26a6 and NHE3 for Enterocyte PHI Regulation and Substrate Transport Rates Via SGLT1 and Pept1 Mingmin Chen*, Anurag K. Singh, Ulrike Dringenberg, Regina Engelhardt, Brigitte Riederer, Michael P. Manns, Gabor Kottra, Hannelore Daniel, Manoocher Soleimani, Gary E. Shull, Ursula E. Seidler

T1872

Alterations in Transporters and Regulators At the Base of Mouse Colonic Crypts After Genetic Disruption of the NHE2 Isoform Na+/H+ Exchanger Yanfang Guan*, Michael P. Humphreys, Marshall H. Montrose



T1873

Activation of Intestinal Na+/H+ Exchanger 2 (NHE2) By Platelet Activating Factor Amika Singla*, Ali Esmaili, Shivani Katyal, Seema Saksena, Ravinder K. Gill, Waddah A. Alrefai, Krishnamurthy Ramaswamy, Pradeep K. Dudeja

T1874

Functional Role of the Sodium Hydrogen Exchanger Nhe4 in Human Colon Elizabeth Arena*, Walter Longo, John P. Geibel

T1875

Increased Glial Glutamate Transporter Eaat2 Expression Reduces Visceral Pain Response in Mice Robert L. Stephens*, C. G. Lin, Y. Lin, J. T. Travers

T1876

Lubiprostone Activation of Cl- Currents Does Not Involve CA2+, cAMP, or PKA John Cuppoletti*, Danuta H. Malinowska, Kirti Tewari, Jayati Chakrabarti, Katrin Mende, Ryuji Ueno

T1877

Clc-2-Targeted SIRNA Eliminates Lubiprostone Activation of Cl- Currents in T84 Cells John Cuppoletti*, Danuta H. Malinowska, Kirti Tewari, Jayati Chakrabarti, Ryuji Ueno

T1878

Hydroxylases Regulate Intestinal Epithelial Secretory Function Karen Lawler, Cormac T. Taylor, Stephen J. Keely*

P-278

T1879

PAR2-Induced Epithelial Chloride Secretion Involves Phospholipase C (PLC) and Both Protein Kinase C (PKC)β1 and PKCδ Signaling Jacques Q. van der Merwe*, Wallace K. MacNaughton

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Nutrition & Obesity

NUTRIENT ABSORPTION, MALABSORPTION, TRANSPORT AND METABOLISM Participants will be able to: • Learn more about the clinical aspects of nutrient absorption and malabsorption, metabolism and transport. T1880



Mechanisms of Metformin-Induced Inhibition of Intestinal D-Glucose Absorption Yassine Sakar, Bouchra Meddah, My A. Faouzi, Y. Cherrah, André Bado, Robert A. Ducroc*

T1881



Pyridoxine Uptake By Colonocytes: A Specific and Regulated Carrier-Mediated Process Zainab M. Said, Veedamali S. Subramanian*, Nosratola D. Vaziri, Hamid M. Said

T1882

Differentiation-Dependent Up-Regulation of Folate Uptake in Human Intestinal Epithelial Cells Veedamali S. Subramanian*, Jack Reidling, Hamid M. Said

T1883

CIS-Diammineplatinum(II)Dichloride Up-Regulates Amino Acid Transport in Human Intestinal Epithelial Cells Satoko Nose*, Masafumi Wasa, Keisuke Nose, Masahiro Fukuzawa

T1884

Maltase-Glucoamylase Starch α-Glucogenic Activity Regulates Complimentary Mouse Prandial Gluconeogenesis Rates Buford L. Nichols*, Roberto Quezada-Calvillo, Zihua Ao, Bruce R. Hamaker, Juan C. Marini, Farook Jahoor

T1885

Intestinal Thiamin Uptake in a Thiamin Transporter-2 Knockout Mouse Model Jack Reidling*, Hamid M. Said

T1886

Zentase, a Novel Pancreatic Enzyme Product (Pep), Is Effective in Mild, Moderate, and Severe Exocrine Pancreatic Insufficiency (Epi) James E. Heubi*, Steven R. Boas, Kathryn Blake, Abdel Rahman H. Nasr, Marlyn S. Woo, Gavin R. Graff, Karen A. Hardy, Rodolfo Amaro-Galvez, Massimo Latino, Candace Lee

T1887

Red Wine Polyphenols Reduce Postprandial Lipid Peroxidation END Products Absorption Moshe Ligumsky*, Shlomit Gorelik, Joseph Kanner, Ron Kohen

T1887a

Inhibition of Intestinal Heme Transport By the Metalloporphyrin Cr-Tmp Mark T. Worthington*, Jay Umbreit, Wyeth Callaway, Jerry Bommer

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC AGA Institute Poster Session 8:00 AM - 5:00 PM

T1900

Sails Pavilion San Diego Convention Center

Sponsored by: Pancreatic Disorders

EXPERIMENTAL PANCREATITIS II Participants will be able to: • Understand the pathogenesis and genetic basis of pancreatic injury, chronic pancreatitis, and fibrosis. T1888



T1889



T1890

Tocotrienols Destabilize the Mitochondrial Electron Transport Chain (Metc) Setting Off Mitochondrial Oxidative Stress, BAX Activation, and Autophagic and Apoptotic Cell Death in Activated Pancreatic Stellate Cells (PSCs) Mariana Rickmann*, Ana González, Xavier Molero, Eva C. Vaquero TGF-β Regulates Nerve Growth Factor (NGF) Expression in Pancreatic Stellate Cells By Activation of the Alk-5 Pathway Stephan L. Haas*, Robert Jaster, Eliza Wiercinska, Haristi Gaitantzi, Ralf Jesnowski, Johannes M. Löhr, Manfred V. Singer, Steven Dooley, Katja Breitkopf



Bone Marrow-Derived Pancreatic Stellate Cells in Mice Takashi Watanabe*, Atsushi Masamune, Kazuhiro Kikuta, Tooru Shimosegawa

T1891

The Urokinase System Plays a Critical Role in Pancreatic Stellate Cell Activation Aurelia Lugea*, Xiaomeng Wu, Dasari Srividya, Stephen J. Pandol

T1892

Plasminogen Activator Inhibitor-1 Mediates Fibrogenesis After Cerulein-Induced Pancreatitis Aurelia Lugea*, Xiaomeng Wu, Dasari Srividya, Stephen J. Pandol

T1893

The Focal Adhesion Kinases Are Present in Pancreatic Stellate Cells and Are Differentially Activated By Diverse Stimuli Andrea Pace*, Friso Nast, Marc J. Berna, Daniel Benten, Ansgar W. Lohse, Michael Blaeker

T1894

Abstinence Promotes Regression While Continued Alcohol Intake Promotes Persistence of LPS-Induced Pancreatic Injury in Alcohol-Fed Rats Alain Vonlaufen*, Zhihong Xu, Lu Yang, Phoebe Phillips, Xuguo Zhang, Ron Pirola, Jeremy S. Wilson, Minoti V. Apte

T1895

Fibroblast Populations in the Regenerated Rat Pancreas Gisela Sparmann*, Marie-Luise Kruse, Robert Jaster, Stefan Liebe, Joerg Emmrich

T1896

Gram-Positive Infection Provokes Pancreatic Fibrogenesis Kyoko Shimizu*, Keiichi Morishita, Ikuko Haruta, Keiko Shiratori, Makio Kobayashi

T1897

Beer But Not Ethanol Stimulates Amylase Secretion in Differentiated Rat Pancreatic Acinar Cell Line Ar4-2j and Freshly Isolated Acinar Cells Andreas Gerloff*, Manfred V. Singer, Peter Feick

T1898

Organotypic Culture Modelling of Pancreatic Cancer Fieke E. Froeling*, Tariq A. Mirza, Ningfeng Fiona Li, Ian R. Hart, Hemant Kocher

T1899

The Meis Tale Transcription Factor Regulates K19 Gene Transcription in Pancreatic Ductal Epithelial Cells Johannes von Burstin*, Melanie P. Wescott, Therese B. Deramaudt, Anil K. Rustgi

Hepatocyte Growth Factor in Concert with PDX-1 Homeodomain Transcription Factor Regulate Pancreatic Ductal Cell Branching Morphogenesis Melanie P. Wescott, Johannes von Burstin*, Therese B. Deramaudt, Steven D. Leach, Anil K. Rustgi

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: BASIC / BILIARY T1901

Systemic Inflammatory Response After Natural Orifice Translumenal Surgery - Transvaginal Cholecystectomy in Porcine Model Daniel K. Tong*, Joe Fan, Simon Law, Wai-Lun Law

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: BASIC / COLON-RECTAL T1902



Curcumin Inhibits the Mammalian Target of Rapamycin Subunits Rictor and Raptor in Colon Cancer Cells Sara M. Johnson*, B. M. Evers

T1903

Increased Expression of Pontin in Human Colorectal Cancer Tissue Johannes C. Lauscher*, Jörn Gröne, Christoph Loddenkemper, Heinz J. Buhr, Hubert G. Hotz, Otmar Huber

T1904

Human Acute Immune Response to Colon and Rectal Surgery - Comparison Between Open, Laparoscopic and Hand Assisted Resection Laurie S. Norcross*, Melissa Donigan, John Aversa, Paul Williamson, Samuel DeJesus, Renee Mueller, Andrea Ferrara, Cheryl H. Baker, Joseph T. Gallagher

T1905



Src Kinase Inhibition May Inhibit Experimental Cancer Metastasis Njwen Anyangwe*, David H. Craig, Jochem Van der Voort Van Zyp, Marc D. Basson

T1906

CD8+ T Cell Infiltration and Cancer Recrurrence in Squamous Cell Cancer of the Anus Sonia Ramamoorthy*, Katsumi N. Miyai, Linda Luo, John M. Carethers

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: BASIC / ESOPHAGEAL T1907



Inhibition of YB-1 As a Novel Approach to Decrease the Expression of EGFR, HER-2 and IGF-1R in Esophageal Cancer Sabrina Thieltges*, Tanya Kalinina, Uta Reichelt, Jussuf T. Kaifi, Yogesh K. Vashist, Paulus G. Schurr, Peter R. Mertens, Ronald Simon, Jakob R. Izbicki, Emre F. Yekebas

T1908



Gene Polymorphisms of ERCC1 Predict Response to Neoadjuvant Radiochemotherapy in Esophageal Cancer Ralf Metzger*, Ute Warnecke-Eberz, Elfriede Bollschweiler, Daniel Vallbohmer, Jan Brabender, Arnulf H. Hoelscher

T1909

Successful Evaluation of a New Animal Model Using Mice for Esophageal Adenocarcinoma Joerg Theisen*, Matthias C. Raggi, Helmut Friess

Denotes DDW Poster of Distinction

P-279

T U E S D A Y MAY 20

POSTER SESSIONS—BASIC T U E S D A Y

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: BASIC / HEPATIC

SSAT POSTER SESSION II: BASIC / STOMACH

T1910

Postconditioning in Liver Ischemia-Reperfusion Injury Roberto Teixeira*, Nilza Molan, Marcia S. Kubrusly, Marta Privato, Ana Maria M. Coelho, Telesforo Bacchella, Marcel C. Machado

T1920

T1911

Reversibility of Liver Fibrogenesis in Mice - STI571 Inhibit the Activation of Hepatic Stellate Cells Ming-Chin Yu*, Miin-Fu Chen, Tsung-Han Wu, Chi-Neu Tsai, Wei-Chen Lee, Yi-Yin Jan

Pre-Op Antibiotic Gastric Lavage Reduces PostOperative Peritoneal Infection in a Murine Natural Orifice Surgery Model Yoav Mintz, John Cullen*, Santiago Horgan, Bryan J. Sandler, Garth R. Jacobsen, Mark A. Talamini

T1921

Roux-en-Y Gastric Bypass Improves Obesity-Related Steatosis and Is Associated with Reduction in Serum Adiponectin Drew A. Rideout*, Yanhua Peng, Steven S. Rakita, William R. Gower, Min You, Michel M. Murr

MAY 20

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: BASIC / PANCREAS T1912



Calcineurine Inhibitors Accelerate Microvascular Thrombus Formation In Vivo Anja Pueschel*, Nicole Lindenblatt, Juliane Katzfuss, Brigitte Vollmar, Ernst Klar

T1913

OSU-03012, a Celecoxib Derivative, Has Increased Cytotoxicity and Does Not Stimulate Vascular Endothelial Growth Factor Production Regardless of Cyclooxygenase-2 Expression in Pancreatic Cancer Cell Lines Desmond P. Toomey*, Ellen Manahan, Ciara K. McKeown, Annamarie Rogers, Kevin C. Conlon, Joseph Murphy

T1914

Inhibition of VEGF and Not COX-2 Is Effective in a Model of Pancreatic Cancer Angiogenesis Desmond P. Toomey*, Ellen Manahan, Ciara K. McKeown, Annamarie Rogers, Helen McMillan, Stephen Thow, Michael Geary, Kevin C. Conlon, Joseph Murphy

T1915

Anti-Lewis Y Antibody As a Novel Target for Pancreatic Adenocarcinoma Vivian E. Strong*, Achim A. Jungbluth, Peter J. Allen, Laura H. Tang, Lloyd Old, Steven Larson, Jorge Carrasquillo, Yuman Fong

T1916

Differentiation, Origin and Mesothelial Adhesive Potential Affect Growth and Metastasis of Ductal Adenocarcinoma of the Pancreas Soeren Torge Mees*, Christina Schleicher, Mario ColomboBenkmann, Norbert Senninger, Joerg Haier

T1917

Pancreatic RegI and PAP2 Proteins Have Different Potencies On Macrophage TNF Expression Ehab Hassanain*, Domenico Viterbo, Cathy M. Mueller, Martin Bluth, Michael E. Zenilman

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: BASIC / SMALL BOWEL T1918

Cold Ischemia of the Small Bowel Could Be Prolonged By Intestinal Lipid Absorption Before Gut Procurement Judith Junginger*, Theo Maier, Tobias Meile, Markus A. Kueper, Ruth Ladurner, Alfred Koenigsrainer, Jorg Glatzle

T1919

Diurnal Rhythmicity in the p53-Mediated Apoptotic Pathway in Rodent Small Intestine Anita Balakrishnan*, Adam T. Stearns, David B. Rhoads, John S. Young, Stanley W. Ashley, Ali Tavakkolizadeh

P-280

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED COMBINED AASLD Poster Session 8:00 AM - 5:00 PM

T1933

Significance of Inflammatory Mediators in Hepatocellular Carcinoma Yuji Ishii*, Ryusuke Ito, Taro Sakamoto, Shigeki Wakiyama, Hiroaki Shiba, Takeyuki Misawa, Yuichi Ishida, Katsuhiko Yanaga

T1934

Recent Clinical Features in Japanese Hepatocellular Carcinoma with Alcoholic Liver Disease Ayae Kabutake*, Katsutoshi Tokushige, Etsuko Hashimoto, Haruka Noto, Maki Tobari, Satoru Yatsuji, Makiko Taniai, Keiko Shiratori

T1935

An Increased Iron Status Is Associated with a Poor Prognosis in Patients with Hepatocellular Cancer Gerhard Treiber

T1936

Intratumoral Pressure and Local Ablative Therapies for Hepatocellular Carcinoma Chiaki Kawamoto*, Atsushi Yamauchi, Yoko Baba, Koji Yakabi

T1937

Magnitude of B-Viral HCC - Epidemics of B-Viral HCC in Single Institute Experience Hideo Yoshida*, Eriko Goto, Takahisa Sato, Takamasa Ohki, Ryota Masuzaki, Ryosuke Tateishi, Tadashi Goto, Keisuke Hamamura, Fumihiko Kanai, Shuichiro Shiina, Haruhiko Yoshida, Masao Omata

T1939

Prognosis Following Recurrent Therapy After Successful Initial Ablation Therapy for Patients with Unresectable Hepatocellular Carcinoma Manabu Morimoto*, Kazushi Numata, Masaaki Kondou, Akihito Nozaki, Takashi Ogura, Ayumi Amano, Katsuaki Tanaka

T1940

Resection of Hepatic Metastases from Germ Cell Tumor: Is It Worth It? Y. Nancy You*, Bradley C. Leibovich, Florencia G. Que

T1941

Decreasing Platelet Counts Are Associated with the Risk of Hepatocellular Carcinoma Yoko Toda*, Ryosuke Tateishi, Haruhiko Yoshida, Eriko Goto, Takahisa Sato, Takamasa Ohki, Ryota Masuzaki, Tadashi Goto, Hideo Yoshida, Fumihiko Kanai, Keisuke Hamamura, Naoya Kato, Shuichiro Shiina, Takao Kawabe, Masao Omata

T1942

Prospective Randomized Study Comparing Ultrasound and Tri-Phasic CT Scan for Screening for HCC Among Patients with Cirrhosis: The VA Experience Bilal Hameed*, Taimur Khan, Samuel B. Ho, Bashar Aqel, Janet Durfee, Kelly M. McCarthy, Jodi Patterson

Sails Pavilion San Diego Convention Center

HEPATOBILIARY CANCER: CLINICAL AND EXPERIMENTAL T1922

Octreotide for Advanced Hepatocellular Cancer Revisited - Results from a Meta-Analysis Approach Using Single Patient Data Gerhard Treiber

T1923

Radiofrequency Ablation (RFA) in the Treatment of Hepatocellular Carcinoma (HCC) Shuichiro Shiina*, Ryosuke Tateishi, Eriko Goto, Takahisa Sato, Takamasa Ohki, Ryota Masuzaki, Tadashi Goto, Hideo Yoshida, Fumihiko Kanai, Keisuke Hamamura, Jun Imamura, Shuntaro Obi, Haruhiko Yoshida, Takao Kawabe, Masao Omata

T1924

Liver Cell Dysplasia Is Associated with Increased Risk of Hepatocellular Carcinoma Aparajita Singh*, Ibrahim A. Hanouneh, Tarek I. Abu-Rajab Tamimi, Rocio Lopez, Lisa M. Yerian, Nizar N. Zein

T1925

The Efficacy of Ultrasound As a Surveillance Tool for the Early Detection of Hepatocellular Carcinoma Amit Singal*, Reena Salgia, Peter D. Higgins, Mary A. Rogers, Jorge A. Marrero, Michael Volk

T1926

Long-Term Prognosis of Combined HepatocellularCholangiocarcinoma After Curative Resection Jeong-Hoon Lee*, Yoon Jun Kim, Bum Joon Park, Donghee Kim, Yong Jin Jung, Jung-Hwan Yoon, Chung Yong Kim, Hyo-Suk Lee

T1927

Treatment Response Evaluated By Tumor Markers Can Predict Prognosis of Hepatocellular Carcinoma Independently of Radiological Evaluation Ryosuke Tateishi*, Shuichiro Shiina, Hideo Yoshida, Tadashi Goto, Eriko Goto, Takahisa Sato, Takamasa Ohki, Ryota Masuzaki, Fumihiko Kanai, Keisuke Hamamura, Haruhiko Yoshida, Takao Kawabe, Masao Omata

T1928

Safety Results of a Phase I/II Study with Oncolytic Herpes Simplex Virus, Nv1020, Administered Repeatedly Via Hepatic Artery Infusion Prior to 2ndLine Chemotherapy, in Patients with Colorectal Adenocarcinoma Metastatic to the Liver John J. Nemunaitis, David A. Geller, Matthias Karrasch*, Anette E. Knoll, Axel Mescheder, Neil Senzer, Kenneth K. Tanabe, Tony Reid

T1929

Alcohol Consumption and Not Metabolic Abnormalities Is Associated with Increased Hepatocellular Carcinoma Risk in Patients with END-Stage Liver Disease Tarek I. Abu-Rajab Tamimi*, Ibrahim A. Hanouneh, Ribhi Hazin, Rocio Lopez, Nizar N. Zein

T1943

Molecular Imaging of Hepatic Fibrogenesis Using a Nanomolar Affinity Tc-99m-Labeled Small Molecule Trimer Specific for the αVβ6 Integrin Yury Popov*, Preeti Misra, Kumar R. Bhushan, Nezam Afdhal, John V. Frangioni, Detlef Schuppan

T1930

Managing Hemorrhagic Complications After Radiofrequency Ablation Therapy for Liver Tumors Eriko Goto*, Ryosuke Tateishi, Shuichiro Shiina, Takahisa Sato, Takamasa Ohki, Ryota Masuzaki, Jun Imamura, Tadashi Goto, Hideo Yoshida, Fumihiko Kanai, Keisuke Hamamura, Haruhiko Yoshida, Masao Omata

T1944

T1931

Vitamin D Levels in Cirrhosis and Hepatocellular Carcinoma Zahid Azam*, Zaigham Abbas, Uzma Saleem, Wasim Jafri

TRANSIENT ELASTOGRAPHY (Fibroscan) in Hepatitis C Native Liver vs. Liver Transplant Recipients with Recurrence: Diagnostic Performance and Predictors of Advanced Fibrosis José C. Marin-Gabriel*, J. B. De-la-Cruz, María Tocado, Yolanda Rodriguez-Gil, Ana M. Martin-Algibez, Inmaculada Fernandez-Vazquez, Maria Luisa Manzano, Jose B. DiazTasende, Jose A. Solis-Herruzo, Gregorio Castellano

T1945

Failure of Liver Stiffness Measurement with Fibroscan: Prevalence and Prognostic Score José C. Marin-Gabriel*, J. B. De-la-Cruz, María Tocado, Yolanda Rodriguez-Gil, Inmaculada Fernandez-Vazquez, Ana M. Martin-Algibez, Maria Luisa Manzano, Jose B. DiazTasende, Jose A. Solis-Herruzo, Gregorio Castellano

T1932

Expanded Criteria for Liver Transplantation in Cirrhotic Patients with Hepatocellular Carcinoma Maurício Silva*, Angel Moya, Marina Berenguer, Martin Prieto, Fernando Sanjuan, Rafael Lopez-Andujar, Rodrigo Torres-Quevedo, Victoria Aguilera, Angelo Mattos, Jose Mir

Denotes DDW Poster of Distinction

P-281

T U E S D A Y MAY 20

POSTER SESSIONS—COMBINED T U E S D A Y

T1946

Diagnostic Utility of TRANSIENT ELASTOGRAPHY (Fibroscan) for Assessing Liver Fibrosis in Patients with Chronic Hepatitis C vs. Other Liver Diseases José C. Marin-Gabriel*, J. B. De-la-Cruz, María Tocado, Yolanda Rodriguez-Gil, Ana M. Martin-Algibez, Inmaculada Fernandez-Vazquez, Maria Luisa Manzano, Jose B. DiazTasende, Jose A. Solis-Herruzo, Gregorio Castellano

T1947

Real-Time Elastography - a Pilot Study for Non-Invasive Detection of Small Hepatocellular Carcinoma in Cirrhotic Patients Liana Gheorghe*, Speranta Iacob, Razvan Iacob, Gabriel Becheanu, Mona Dumbrava, Cristian Gheorghe, Iulia I. Simionov, Ioana Lupescu, Irinel Popescu

MAY 20

T1957



Metabolic Syndrome and Visceral Obesity Quantified By Abdominal CT Scan As Risk Factors for Reflux Esophagitis: A Case-Control Study of 7078 Health Check-Up Subjects Su Jin Chung*, Donghee Kim, Seon Hee Lim, Joo Sung Kim, Hyun Chae Jung, In Sung Song

T1958

Increased Swallowing Frequency in GERD Is Likely to Be Caused By Perception of Reflux Episodes Gerrit J. Hemmink*, Bas L. Weusten, Albert J. Bredenoord, Robin Timmer, Andreas J. Smout

T1959

Supragastric Belching in Patients with Reflux Symptoms Gerrit J. Hemmink*, Albert J. Bredenoord, Bas L. Weusten, Robin Timmer, Andreas J. Smout

T1960

Acidic pH Upregulates TRPV1 Expression in Sv40 TAntigen-Immortalized Human Esophageal Epithelial (Het-1A) Cells Yue Zheng*, Banani Banerjee, Parvaneh Rafiee, Jyoti N. Sengupta, Irshad Ali, Reza Shaker

T1948

Evaluation of the Effectiveness of Radiofrequency Ablation for Hepatic Malignancies: Usefulness of Virtual CT Sonography Using Magnetic Navigation Yasunori Minami, Satoshi Kitai*, Masatoshi Kudo

T1949

Role of Magnetic Resonance Elastography to Assess Hepatic Fibrosis Mashal Jatoi*, Forrest B. Walker, Vinodh Jeevanantham, Alvin Silva, Elizabeth J. Carey, Jorge L. Rakela, Giovanni DePetris, Hugo E. Vargas

T1961

The Role of Gastro-Esophageal Pressure Gradient On Gastroesophageal Reflux in Morbidly Obese Patients Fernando Fornari*, Carlos Augusto S. Madalosso, Ricard Farré, Sidia M. Callegari-Jacques, Richard R. Gurski

T1950

Contrast Enhanced Sonography for Hepatic Malignancies: Value of Defect RE-Injection Test Kinuyo Hatanaka*, Masatoshi Kudo, Yasunori Minami

T1962

T1951

Real-Time Elastography for Noninvasive Diagnosis of Liver Fibrosis Mami Kanamoto*, Mitsuo Shimada, Toru Ikegami, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Koji Sugimoto, Takuya Tokunaga

Segmental Contraction of Distal Esophagus As a Mechanism of Proximal Reflux in GERD Patients: A Combined Mano-Impedance and Fluoroscopic Study Fortunée I. Habib*, Mentore Ribolsi, Luca Occhigrossi, Carlo Cohen, Michele Cicala

T1963

Pharyngeal Reflux of Gastric Content: Mechanisms in Healthy Controls, Gastroesophageal Reflux and Obstructive Sleep Apnea Patients Shiko Kuribayashi*, Lilani P. Perera, Muhammad Hafeezullah, Ahmed Nasef, Linda Tatro, Candy Hofmann, Adeyemi Lawal, Syed Q. Hussaini, Jasmohan S. Bajaj, Reza Shaker

T1964

Dilation of Intercellular Spaces in Esophageal Epithelium in Non-Erosive and Erosive Reflux Disease Patients and Appropriate Controls Helmut Neumann*, Klaus Mönkemüller, Frank Dombrowski, Lucia C. Fry, Michael Bellutti, Peter Malfertheiner

T1965

Low pH Induces Epithelial-Mesenchymal Transition in Esophageal Squamous Cells - Role of Cyr61 Jianyuan Chai*, Manith Norng, Jasmine Chai

T1966

Effect of Non-Selective and Selective Cyclooxygenase (COX)-2 Inhibitors and Nitric Oxide (No)-Releasing Aspirin On Esophageal Damage in the Rat Model of Reflux Esophagitis Michal Pawlik*, Tomasz Brzozowski, Peter C. Konturek, Zbigniew Sliwowski, Magdalena Mazurkiewicz-Janik, Slawomir Kwiecien, Danuta Drozdowicz, Stanislaw J. Konturek, Wieslaw W. Pawlik

T1967

TRPV1 Expression Associated with Nerve Growth Factor Mediates the Esophageal Visceral Hypersensitivity Takahiro Suzuki*, Norimasa Yoshida, Katsura Mizushima, Kazuhiro Kamada, Osamu Handa, Tomohisa Takagi, Satoshi Kokura, Hiroshi Ichikawa, Yuji Naito, Hirofumi Kuramoto, Toshikazu Yoshikawa

T1952

JNK Inhibitor Blocks Progression of Rat ChemicalInduced Hepatocellular Carcinoma Hiromitsu Nagata*, Etsuro Hatano, Masaharu Tada, Koji Kitamura, Hiroyuki Asechi, Masato Narita, Atsuko Yanagida, Iwao Ikai, Shinji Uemoto, Koichi Matsuzaki

T1953

PPARα Activation Is Essential for Severe Hepatic Steatosis and Hepatocellular Carcinoma Induced By HCV Core Protein Naoki Tanaka*, Moriya Kyoji, Kazuhiko Koike, Toshifumi Aoyama

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

GERD PATHOGENESIS Participants will be able to: • Learn advances in clinical and basic mechansisms in GERD pathogenesis. T1954



Physicochemical Basis for Dilated Intercellular Spaces in Non-Erosive Acid-Damaged Rabbit Esophageal Epithelium Nelia A. Tobey*, Todd M. Gambling, Ximena Vanegas, John L. Carson, Roy C. Orlando

T1955



Presence of Hiatal Hernia (HH)Is Not Related to Obesity and Increasing Age Sachin B. Wani*, Ajay Bansal, Amit Rastogi, Krishna Pondugula, Sandy B. Hall, April D. Higbee, Prateek Sharma

T1968

T1956

Scintigraphic Imaging of the Postprandial Acid Pocket in Healthy Subjects and Gastroesophageal Reflux Disease Patients Hanneke Beaumont*, Jan W. de Jong, Roelof J. Bennink, Guy E. Boeckxstaens

Overweight and Waist Circumference Are Risk Factors for Gastroe-Esophageal Reflux Disease Roy Anggiansah, Rami Sweis, Terry Wong, Mark R. Fox*, Angela Anggiansah

T1969

Stimulation of Wnt Ligand and Wnt Target Gene Expression By Low pH in Human Esophageal Epithelial Het-1A Cells Irshad Ali*, Yue Zheng, Parvaneh Rafiee, Reza Shaker



P-282

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED T1970

The Desmosomal Proteins Desmoglein and Plakoglobin Are Up Regulated in Patients with Both Non-Erosive and Erosive Gastroesophageal Reflux As Compared to Controls Klaus Mönkemüller*, Thomas Wex, Doerthe Kuester, Lucia C. Fry, Albert Roessner, Peter Malfertheiner

T1971

Is Obesity Associated with Increased Risk of Hiatal Hernia (HH)? a Prospective Endoscopy Study in GERD Patients and Non-Reflux Individuals Justin Wu*, Yawen Chan, Jessica Ching, Larry Lai, Dorothy K. Chow, Grace Wong, Joseph J. Sung, Francis K. L. Chan

T1972

T1973

Mechanics of the Esophagogastric Junction in Postfundoplication Patients As Assessed By Functional Luminal Imaging Probe Monika A. Kwiatek*, William J. Bulsiewicz, Sudip K. Ghosh, Barry P. McMahon, Hans Gregersen, Peter J. Kahrilas, John E. Pandolfino Proton Pump Inhibitor Treatment Ameliorates Dilated Intercellular Space, Decrease and Dislocalization of Esophageal Mucosal Tight Junction Proteins in a Rat Chronic Acid Reflux Esophagitis Model Tadayuki Oshima*, Junichi Koseki, Seiichi Iizuka, Toshihiko Tomita, Takayuki Matsumoto, Jun Sakurai, Hiroto Miwa

T1974

Chronic Stress Induced Dilated Intercellular Spaces of Esophageal Mucosa in Rats, Especially in Female Liping Duan*, Dan-Yun Zhao

T1975

Increased TRPV1 Gene Expression in Esophageal Mucosa of Patients with Non-Erosive and Erosive Reflux Disease Michele Pier Luca Guarino*, Ling Cheng, Jose Behar, Francesco Panzera, Piero Biancani, Michele Cicala

T1976

T1977

T1978

T1979

T1980

T1981

T1982

Increased Risk of Gastroesophageal Reflux Disease Associated with Gene Polymorphisms in NOD1 Signaling Pathway in Helicobacter pylori Infected Patients Tomoyuki Oikawa*, Akira Imatani, Sho Asonuma, Naoki Asano, Yasuhiko Abe, Tomoyuki Koike, Katsunori Iijima, Shuichi Ohara, Tooru Shimosegawa Pressure Dynamics in the Lower Esophagus in Subjects with Hiatal Hernia Using High-Resolution Manometry Annapurna Korimilli*, Anil K. Vegesna, Larry S. Miller, Henry P. Parkman, Robert S. Fisher Gastric Pressure Increases Above Lower Esophageal Sphincter (LES) Pressure in Subjects with Hiatal Hernia and GERD During Increases in Intra-Abdominal Pressure Annapurna Korimilli*, Anil K. Vegesna, Larry S. Miller, Henry P. Parkman, Frank K. Friedenberg, Robert S. Fisher Enhanced Esophageal NADPH Oxidase Expression in Response to Acid Eisuke Iwasaki*, Hidekazu Suzuki, Tatsuhiro Masaoka, Toshihiro Nishizawa, Tetsufumi Takahashi, Yoshimasa Saito, Hitoshi Tsugawa, Toshifumi Hibi

T1983

Short Duration of Acid Exposure Sensitizes the Esophagus to Perception of Weakly Acidic and Mixed Reflux in Non-Erosive Reflux Disease (NERD) Patients Mentore Ribolsi*, Sara Emerenziani, Renato Caviglia, Michele Pier Luca Guarino, Michele Cicala

T1984

Refluxate Characteristics Leading to the Specific Symptoms of Heartburn, Regurgitation, Chest Pain, and Cough in Acid Suppressed Patients Brandon M. Craft*, Marcelo F. Vela, Elizabeth G. Hill, Neeraj Sharma, Radu Tutuian, Donald O. Castell

T1985

Differential Gene Expression in the Duodenum May Contribute to Symptom Generation in GERD Durk Vries, de*, Jose Ter Linde, Margot A. van Herwaarden, Matthijs P. Schwartz, André Smout, Melvin Samsom

T1986

Helicobacter Is An Independent Protective Factor for Erosive Esophagitis Su Youn Nam*, Il Ju Choi, Kyung woo Park, Byung Chang Kim, Kum Hei Ryu

T1987

H. pylori Infection Is Not Involved in the Pathogenesis of Erosive and Non-Erosive Reflux Disease in a Young Population: Studies from a Health Check-Up Program of 678 Consecutive Japanese Subjects in Their 20s Tomohiko Shimatani*, Seiko Hirokawa, Kazuko Hamai, Yumiko Tawara, Mutsuko Matsumoto, Ayumi Furukawa, Susumu Tazuma, Masaki Inoue

T1988

Short Segment Acid Reflux: Characterization with 24Hour Esophageal Impedance-Double pH Monitoring Adriana Lazarescu*, Raf Bisschops, Ingrid Demedts, Jan F. Tack, Guido N. Tytgat, Daniel Sifrim

T1989

Weakly Acidic Gastroesophageal Reflux: Further Characterization with Impedance-Double pH Monitoring Adriana Lazarescu*, Raf Bisschops, Ingrid Demedts, Jan F. Tack, Guido N. Tytgat, Daniel Sifrim

T1989a

Effect of Intraesophageal Capsaicin Instillation On Esophageal Chemosensitivity and Desensitization in Different Phenotypes of GERD Maryel Mejia*, Maryel Mejia, Florencia Vargas, Miguel A. Valdovinos



AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

GERD: DIAGNOSTIC TESTING Participants will be able to: • Update in GERD diagnostic testing. T1990



How Does GERD Evolve During a 5-Year Follow-Up Period? the Progerd Study Peter Malfertheiner*, Marc Nocon, Michael R. Höcker, Daniel Jaspersen, Joachim Labenz, Hans R. Koelz, Tore Lind, Manfred Stolte, Michael Vieth, Stefan Willich

Study of Intercellular Space of Normal Esophagus with Electron Microscopy: Cutoff Values and Number of Measurements - Are They Theoretically Reasonable? Sanghoon Park, Yong Sik Kim*, Chul Young Kim, Ju Young Kim, Jin Su Jang, Yong Dae Kwon, Bora Keum, Yeon Seok Seo, Yoon-Tae Jeen, Hong Sik Lee, Chang Sub Uhm, Hoon Jai Chun, Soon Ho Um, Sang Woo Lee, Jai Hyun Choi, Chang Duck Kim, Ho Sang Ryu, Sung Joon Lee

T1991

Gastroesophageal Reflux Disease in Children and Adolescents in Primary Care: Incidence, Prevalence and Treatment Patterns Ana Ruigomez*, Mari-Ann Wallander, Per Lundborg, Saga Johansson, Luis Garcia-Rodriguez



Modified Glucose Clearance Test (Mgct): A Novel NonInvasive Method for Diagnosing Differentially Between Non-Erosive Reflux Disease (NERD) and Erosive Esophagitis (EE) Haruka Fujinami*, Takahiko Kudo, Toshiro Sugiyama

T1992

Tolerability and Performance Characteristics of the BRAVOTM pH Capsule in a Large Multinational Study of Patients with Upper GI Symptoms Gregory A. Cote*, John E. Pandolfino, Sudip K. Ghosh, Peter J. Kahrilas

Symptomatic Differences Between NERD and RE Noriaki Manabe*, Ken Haruma, Jiro Hata, Tomoari Kamada, Hiroaki Kusunoki



Denotes DDW Poster of Distinction

P-283

T U E S D A Y MAY 20

POSTER SESSIONS—COMBINED T U E S D A Y MAY 20

T1993



Persistent Symptoms On PPI: Abnormal Reflux or a Sensitive Esophagus? Neeraj Sharma*, Amit Agrawal, Janice Freeman, Marcelo F. Vela, Donald O. Castell

T1994

A Five Minute Symptom Index Is Reliable Neeraj Sharma*, Amit Agrawal, Janice Freeman, Donald O. Castell

T1995

Crafted for Use in Clinical Trials: The Mayo Dysphagia Questionnaire - 30 Day Judith McElhiney*, Matthew R. Lohse, Amindra S. Arora, Adil A. Abdalla, Joanna M. Peloquin, Debra M. Geno, Melissa Kuntz, Felicity Enders, Mary Fredericksen, Yulia Khan, Gianrico Farrugia, Joseph a. Murray, G. Richard Locke, Nicholas J. Talley, Nancy N. Diehl, Jeffrey A. Alexander, Timothy J. Beebe, Ann M. Harris, Alan R. Zinsmeister, Rayna M. Grothe, Michael D. Crowell, Dawn L. Francis, April Grudell, MhdMaan Alkhatib, Yvonne Romero

T1996

Abnormal Multichannel Intraluminal Impedance Testing Predicts Symptomatic Outcome Michael J. Hersh*, Aziz A. Aadam, Gregory S. Sayuk, C. Prakash Gyawali

T1997

A Novel Technique for On-Line Assessment of Esophageal Shortening Induced By Balloon-Distension Lars Fandriks*, Claes Jonsson

T1998

Evaluation of the Proton Pump Inhibitor (PPI) Test in GERD pts with and Without Erosive Esophagitis: Results from the Diamond Study Peter Bytzer*, Roger Jones, Nimish Vakil, Ola Junghard, Tore Lind, John Dent

T2006

Measurement of Pharyngeal pH: A New Technology and Normal Values Shahin Ayazi*, John C. Lipham, Jeffrey A. Hagen, Andrew Tang, Jessica M. Leers, Arzu Oezcelik, Emmanuele Abate, Steven R. DeMeester, Farzaneh Banki, Tom R. DeMeester

T2007

Role of Esophageal Histology in the Diagnosis of Gastroesophageal Reflux Disease (GERD) in Patients Without Erosive Disease By Standard Endoscopy or Narrow Band Imaging (NBI) Christopher R. Lynch*, Sharad C. Mathur, Ajay Bansal, Amit Rastogi, Krishna Pondugula, Sachin B. Wani, John D. Keighley, April D. Higbee, Prateek Sharma

T2008

In Refractory GERD Patients Should We Perform Impedance On Therapy or pH Monitoring Off Therapy? Brian S. Smith*, James C. Slaughter, Reid M. Ness, Michael F. Vaezi

T2009

Cyp2c19 Genetic Polymorphism Related to the ProtonPump Inhibitor Test in Chinese Patients with Symptoms Suggestive of Gastro-Esophageal Reflux Disease Ping-Huei Tseng, Yi-Chia Lee, Han-Mo Chiu, Hsiu-Po Wang, Jaw-Town Lin, Ming-Shiang Wu*

T2010

Ambulatory 24-H Combined Impedance-pH Monitoring On Acid Suppressive Therapy - Lessons Learned from Swiss Healthy Volunteers Patrick Janiak*, Daniel Pohl, Michael Fried, Radu Tutuian

T2011

Impedance-pH Monitoring Improves Detection of Reflux in Patients with Respiratory Disease Roger P. Tatum*, Linda Ding, A. Valeria Martin, Brant K. Oelschlager

T2012

A Decline in the Safety and Performance of the BRAVO™ Wireless pH Capsule Dawn L. Francis

T1999

Premature Capsule Detachment Limits Utility of Wireless pH Monitoring in Patients with Eosinophilic Esophagitis Carol Garrean*, Nirmala Gonsalves, Ikuo Hirano

T2013

T2000

Simultaneous Monitoring of Esophageal Acid Exposure and Gastric Acid Environment Using BRAVO System Junichi Akiyama*, Yuko Hiraga, Yuzo Yago, Toshiyuki Sakurai, Keita Sasajima, Masao Kobayakawa, Ryosuke Shoda, Akira Muraoka, Naohiko Masaki, Naomi Uemura

Impact of Wireless Versus Traditional Catheter Based pH Metry On Activities of Daily Living Angela G. Bradley*, Hack J. Kim, John K. DiBaise, David E. Fleischer, Virender K. Sharma, Michael D. Crowell

T2014

Feasiblity of Proximal Esophageal Wireless Capsule Placement: Blinded Sham-Controlled Study Eric L. Sumner*, James C. Slaughter, Farnoosh Farrokhi, Michael F. Vaezi

Endoscopic Findings of Gastroesophageal Reflux Disease in Turkey: Multicenter Prospective Study (Gorhen) Serhat Bor*, Rukiye Vardar, Enver Vardar, Serap Takamz, Zeynel A. Mungan

T2015

Multivariate Analysis of Predictors for Severity of Mucosal Lesions in Patients with GERD Symptoms (Mapsomal): A Clinical, Epidemiological and Endoscopic Survey Nora B. Zschau*, William Tam, Jane M. Andrews, Richard H. Holloway, Mark Schoeman, Gerald J. Holtmann

T2016

Novel Integration of Video and pH/Impedance Recording Coupled with Cardiorespiratory Monitoring for Evaluation of Pediatric Gastroesophageal Reflux Disease Marta Illueca*, Taher Omari, Mike Thomson, Tobias G. Wenzl, Thomas Stuebe, Barbara A. Harrison, Per Lundborg, Geoff Davidson

T2017

Does the Diagnostic Accuracy of Ambulatory 24-pH Monitoring Improve If Cut Off Levels of pH < 3.0 or 2.0 Are Used? Ajay Bansal*, A. Keith Rastogi, Krishna Pondugula, Sachin B. Wani, Amit Rastogi, Sandy B. Hall, Prateek Sharma

T2018

A Composite Symptom Score Using Frequency and Severity Correlates Better to An Objective Measure of Gastro-Oesophageal Reflux Disease (GERD) Than One Scoring Frequency of Symptoms Alone Lakmali Amarasiri*, Arunasalam Pathmeswaran, Channa D. Ranasinha, Janaka de Silva

T2001

T2002

The Accuracy and Predictors of a Clinical Diagnosis of GERD By Family Practitioners and Gastroenterologists Nimish Vakil*, John Dent, Roger Jones, Katarina Halling, Tore Lind, Ola Junghard

T2003

Comparison of the Extent of Duodenogastroesophageal Reflux (Dger) and Acid Reflux Between Patients Who Failed Symptomatically and Those Who Demonstrated Complete Symptom Relief On Proton Pump Inhibitor (PPI) Once Daily Tomas Navarro-Rodriguez*, Anita Gasiorowska, Bridget Moty, Jeannette Powers, Hemanth Gavini, Ronnie Fass

T2004

Actigraphy Is a Simple and Accurate Technique to Determine Esophageal Acid Exposure During Sleep in Patients Undergoing pH Testing Ibraheem Mizyed, Larissa M. Allen, Tomas NavarroRodriguez*, Anita Gasiorowska, Bridget Moty, Jeannette Powers, Ronnie Fass

T2005

P-284

Dual Probe pH Monitoring: Improved Definition of Normal Proximal Acid Exposure Shahin Ayazi*, Jeffrey A. Hagen, Antereas H. Hindoyan, Jessica M. Leers, Arzu Oezcelik, Emmanuele Abate, Farzaneh Banki, Steven R. DeMeester, John C. Lipham, Tom R. DeMeester

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED T2019

Esophageal Thickness As a Possible Marker of GastroEsophageal Reflux Diseases -a Study Using Abdominal Ultrasonography Toshihiko Tomita*, Hiroko Iijima, Hashimoto Mariko, Shuhei Nishiguchi, Yongmin Kim, Kazutoshi Hori, Takayuki Matsumoto, Hiroto Miwa

T2020

Automatic Versus Manual Impedance Readings: Should We Rely On the Autoscan? Sergio J. Fernández*, Ann Aspirot, Frederick W. Woodley, John Hayes, Sujit M. Philipose, Beth Skaggs, Carlo Di Lorenzo, Hayat Mousa

T2029

Whole-Genome Association Scan (Wgas) for Colorectal Cancer: Replicated SNPs in Samples from the Spanish Epicolon Project Sergi Castellvi-Bel*, Clara Ruiz-Ponte, Ian Tomlinson, Luis Carvajal-Carmona, Jenifer Muñoz, Francesc Balaguer, Victoria Gonzalo, Maria Dolores Giraldez, Richard Houlston, Angel Carracedo, Antoni Castells, Spanish Gastroenterological Association Gastrointestinal Oncology Group

T2030

Large Genomic Deletions of SMAD4, Bmpr1a and PTEN in Juvenile Polyposis Lodewijk Brosens*, W. Arnout van Hattem, Wendy de Leng, Folkert Morsink, Sylvia I. Lens, Ralph Carvalho, Francis M. Giardiello, Johan Offerhaus

T2031



The Outcome of Longterm Surveillance of Lynch Syndrome Families in the Netherlands Hans F. Vasen*, Fokko M. Nagengast, Mariette van Kouwen, Alexandra Langers, Jan-Werner Poley, Annemieke Cats, Silvia Sanduleanu, Andrea E. van der Meulen - de Jong, James C. Hardwick, Wouter H. de Vos, Evelien Dekker, Mike E. Craanen, Jan J. Koornstra, Jan H. Kleibeuker

T2032

The Value of a Colonoscopy-Based Surveillance Program (Csp) for People At Increased Risk for Colorectal Cancer (CRC) Elizabeth C. Chow*, Joanne M. Lane, Stephen Cole, Peter A. Bampton, Graeme P. Young

T2033

Inflammation Related Gene Selenoprotein S Polymorphism and Gastric Cancer Development Tomoyuki Shibata*, Tomiyasu Arisawa, Tomomitsu Tahara, Ichiro Hirata

T2034

A High Incidence of Msh6 Mutations in Amsterdam II Criteria Negative Families Tested in a Clinical Setting D. Ramsoekh*, Anja Wagner, Monique E. van Leerdam, W. Dinjens, E. W. Steyerberg, E. J. Kuipers, Dennis Dooijes

T2035

Results of Surveillance for Hereditary Pancreatic Cancer Using Annual MRI(CP) Wouter H. de Vos*, Heidi Rothenmund, Masoom A. Haider, Stephanie Wilson, Claudia Quammie, Kara Semotiuk, Spring Holter, Michael Shennan, Anne Summers, David Hogg, Anneke van Mil, Daniel W. Hommes, Hans Morreau, Bert A. Bonsing, Martin Wasser, Hans F. Vasen, Steven Gallinger

T2036

Estimating Absolute Risk of Colorectal Cancer Based On Family History: An Epidemiological Approach Clausa Liem, M. E. Leerdam van, Anja Wagner, D. Ramsoekh*, E. J. Kuipers, E. W. Steyerberg

Participants will be able to: • Learn more about cancer susceptibility, polymorphisms and inherited GI cancers.

T2037

Poor Communication Between Providers, Families, and Patients with Increased Colorectal Cancer Risk Lisa Madlensky*, Barbara H. Jung, John M. Carethers

T2026



Clinical, Serological and Histological Parameters Can Predict the Intragastric Extent of Intestinal Metaplasia Annemarie C. de Vries*, Jelle Haringsma, Richard A. de Vries, Frank T. Borg, Nicole Nagtzaam, E. W. Steyerberg, Herman van Dekken, Ernst J. Kuipers

T2038

A Case-Control Study of the Risk Factors for Advanced Serrated Polyps Christopher S. Huang*, Francis A. Farraye, Courtney Shepherd, Shi Yang, Michael J. O'Brien

T2039

T2027



Comparison of Predictive Models and Clinical Criteria for the Identification of Patients with Lynch Syndrome in a Population-Based Cohort of Colorectal Cancer (CRC) Patients Judith Balmaña, Francesc Balaguer*, Sergi Castellvi-Bel, Ewout W Steyerberg, Montserrat Andreu, Xavier Llor, Rodrigo Jover, Antoni Castells, Sapna Syngal

Colorectal Cancer Incidence Rates for American Indian and Alaska Native Populations Vary Five-Fold Between Regions, with a Propensity Toward the Distal Colon and Later Stage At Diagnosis David G. Perdue*, Carin I. Perkins, Jeannette JacksonThompson, Steven S. Coughlin, Faruque Ahmed, Donald Haverkamp, Melissa A. Jim

T2040

T2028

Polymorphism in the Promoter Region of the Metalloproteinase-7 Increases Susceptibility and Risk of Metastasis of Gastric Adenocarcinoma Jiyou Li*, Mengmeng Tian, Ailian Zhao

Poor Compliance with MSI-Analysis in Patients with Colorectal Cancer At High Risk for Lynch Syndrome Margot G. van Lier*, J. de Wilt, J. Wagemakers, W. Dinjens, R. Damhuis, E. J. Kuipers, M. E. Leerdam van

T2021

Is Reduced Chemical Clearance Efficiency During Later Phases of the Feeding Cycle in Symptomatic Infants Related to Declining Frequency of Swallowing? Frederick W. Woodley*, John Hayes, Hayat Mousa

T2022

Predicting Symptom Severity and Treatment Outcome from Esophageal pH Monitoring: Symptom Index (SI) vs. Symptom Associated Probability (SAP) Mark R. Fox*, Russell Canavan, Angela Anggiansah, Terry Wong

T2023

Prevalence of Gastroesophageal Reflux Disease in the Adult Population of the Altos De Jalisco Region in Mexico Edgardo Suarez Moran, Elizabeth Barba Orozco*, José I. Minero Alfaro, Sergio R. Sobrino-Cossio, Paola Figueroa Barojas, Juan C. Lopez-Alvarenga, Ivonne Cedillo Ley

T2024

The Frequency and Risk Factors of Reflux Esophagitis in Health Check Up Subjects of South Korea: Relation to Obesity and Metabolic Syndrome Chang Hwan Choi*, Hong Ju Moon, Sang Joong Kim, Jang Sik Mun, Hyun Woong Lee, Hyung Joon Kim, Jae Hyuk Do, Sae Kyung Chang

T2025

Circadian Rhythm of Gastroesophageal Reflux in Patients Off and On Acid-Suppressive Therapy - Studies Using 24-H Impedance-pH Monitoring Radu Tutuian*, Daniel Pohl, Edoardo Savarino, Patrick Janiak, Michael Fried

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: CANCER SUSCEPTIBILITY, POLYMORPHISMS, AND INHERITED GI CANCERS



Denotes DDW Poster of Distinction

P-285

T U E S D A Y MAY 20

POSTER SESSIONS—COMBINED T U E S D A Y MAY 20

T2041

Evaluation of Mutation Prediction Models in Lynch Syndrome D. Ramsoekh*, Monique E. van Leerdam, Anja Wagner, E. J. Kuipers, E. W. Steyerberg

T2042

Mismatch Repair Gene Product Expression and Colorectal Cancer in Hispanics Wilfredo E. De Jesus-Monge*, Ronghua Zhao, Carmen Gonzalez-Keelan, Stanley R. Hamilton, Miguel RodriguezBigas, Marcia R. Cruz-Correa

T2043

T2044

T2045

T2046

T2047

T2053

Multidrug Resistance 1, Cyclo-Oxygenase-2 and Breast Cancer Related Protein Gene Polymorphisms and Colorectal Cancer Vibeke Andersen*, Mette Østergaard, Jane Christensen, Kim Overvad, Anne Tjønneland, Ulla Vogel

T2054

Utility of Fish As An Adjunct to Cytology in the Screening and Surveillance for Upper Tract Urothelial Carcinoma in Lynch Patients - the Jury Is Out! Ferga C. Gleeson*, Douglas L. Riegert-Johnson, Kevin C. Halling, Lisa Boardman

Mannan-Binding Lectin (Mbl) Polymorphism in Gastroduodenal Diseases in Japan Tomomitsu Tahara*, Tomiyasu Arisawa, Tomoyuki Shibata, Masakatsu Nakamura, Yoshio Kamiya, Hiroshi Fujita, MItsuo Nagasaka, Masami Iwata, Kazuya Takahama, Makoto Watanabe, Hiroshi Nakano, Ichiro Hirata

T2055

Family History of Pancreas, Breast, Colon, Bladder, and Prostate Cancer in Patients with Pancreas Cancer Supports a Syndromic Predisposition Aimee L. Lucas*, Aliye Z. Bill, Caroline Hwang, Elizabeth Verna, Nicole Goetz, John A. Chabot, Harold Frucht

Interleukin 1b (IL-1b)-511 T>C Is Associated with a Favorable Outcome of Gastric Cancer Jun Yu*, Jian Wu, Shiyan Wang, Zhirong Zeng, Linwei Tian, Wai K. Leung, Mingdong Zhang, Pinjin Hu, Joseph JY Sung

T2056

Association of Aoptosis Pathway Genes with the Risk for Gastric Cancer E-Ming Wang*, Ping-I Hsu

Significance and Characteristics of Gastric Cancer in Families with Suspected or Diagnosed Lynch Syndrome Isadora Rosa*, Isabel Claro, Pedro A. Lage, Sara Ferreira, Inês Francisco, Paula C. Rodrigues, Alexandra Suspiro, Paula Chaves, Cristina Albuquerque, Carlos N. Leitão The Association of Polymorphism in Transforming Growth Factor β1 Gene with Progression of Chronic Atrophic Gastritis Yiqiang Liu*, Yang Zhang, Jiyou Li Gene-Gene Interactions and the Risk of Colorectal Neoplasia Is Associated with Variants of the APC and CD24 Genes Michael J. Hall, Eliezer Liberman, Oleg Dulkart, Lior Galazan, Eyal Sagiv, Diana Kazanov, Aharon Halak, Menachem Moshkowitz, Alfred I. Neugut, Nadir Arber*

T2048

Nfkbia Polymorphisms and Their Associations with Susceptibility and Prognosis in Gastric Cancer Jun Yu*, Shiyan Wang, Zhirong Zeng, Jian Wu, Linwei Tian, Wai K. Leung, Mingdong Zhang, Pinjin Hu, Joseph JY Sung

T2049

Exogenous Estrogen Use and Colorectal Cancer Risk, Overall and By Mismatch Repair Protein Expression Status, Among Older Women Paul J. Limburg*, Robert A. Vierkant, Amy J. French, Alice Wang, John D. Potter, Susan Slager, Thomas C. Smyrk, Lisa J. Harnack, Kristin E. Anderson, Charles F. Lynch, Stephen N. Thibodeau, James R. Cerhan

T2050

Nitric Oxide and Reactive Oxygen-Scavenging Systems. the Relevance of Gene Polymorphisms On Gastric Cancer Susceptibility Maria Asuncion Garcia-Gonzalez*, Enrique Quintero, Rafael Benito, Mark Strunk, David Nicolas, Adolfo Parra-Blanco, Santos Santolaria, Federico Sopena, Elena Piazuelo, Pilar Jimenez, Jesús Espinel, Rafael Campo, Maria Luisa Manzano, Fernando Geijo, Miguel Angel Simón, Maria Pellisé, Ferrán González-Huix, Jorge C. Espinos, LLúcia Titó, Luis Bujanda, Manuel Zaballa, María Angeles PérezAisa, Isabel María Méndez-Sánchez, Angel I. Lanas

T2051

T2052

P-286

Genetic Analysis of Base Excision Repair Genes in African-Americans and Caucasians with Colorectal Cancer Sonia Kupfer*, Jeffrey R. Anderson, Jennifer E. Below, Rick Kittles, Nancy Cox, Nathan A. Ellis P53, p21, and p73 Gene Polymorphisms in Gastric Carcinoma in Japan Osamu Shirai*, Naoki Ohmiya, Ayumu Taguchi, Akihiro Itoh, Yoshiki Hirooka, Yasumasa Niwa, Osamu Maeda, Takafumi Ando, Hidemi Goto

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: GASTRIC NEOPLASM: BIOLOGY, DIAGNOSIS AND THERAPY Participants will be able to: • Become familiar with gastric neoplasm: biology, diagnosis and therapy. T2057

Loss of 15-Hydroxyprostaglandin Dehydrogenase Expression Is Associated with Cancer Cell Proliferation and Poor Prognosis in Gastric Cancer Hiroshi Tatsuwaki*, Tetsuya Tanigawa, Toshio Watanabe, Hirohisa Machida, Hirotoshi Okazaki, Masatsugu Shiba, Kazunari Tominaga, Yasuhiro Fujiwara, Nobuhide Oshitani, Kazuya Muguruma, Tetsuji Sawada, Kosei Hirakawa, Kazuhide Higuchi, Tetsuo Arakawa

T2058



Both Transgenic and Host Cyclooxygenase-2 Expression Enhance Gastric Carcinogenesis Through Tumor Angiogenesis Alfred S. Cheng*, Vivian Y. Shin, Kaichun Wu, Yim Ping Wong, Wilson Chong, Jennifer M. Siu, Arthur K. Ching, Minnie Y. Go, Jun Yu, Yiu-loon Chui, C. H. Cho, Daiming Fan, Joseph JY Sung, Wai K. Leung

T2059

Inhibition of Heme Oxygenase-1 By Znpp Enhances the Sensitivity of Gastric Cancer Cells to Anti-Cancer Drug 5-Fluorouracil Enders K. Ng, Ruizhi Wang*, Jun Yu, Ming Y. Li, Billy C. Leung, George G. Chen

T2060

The Prevalence of Cardia Inflammation and PreCancerous Lesions in a High Risk Chinese Cohort Being Screened for Gastric Cancer Khay Guan Yeoh*, Nilesh Shah, Manuel Salto-Tellez, Ming Teh, Jimmy B. So, Khek Yu Ho, Christopher J. Khor, How Cheng Low, Andrea Rajnakova, Chung King Chia, Wee Chian Lim, Tiing Leong Ang, Kwong Ming Fock, Khoon Lin Ling, Choon-Jin Ooi, Feng Zhu, Bow Ho, Yoshiaki Ito

T2061

Male Predominance of Adenocarcinoma of Upper Gastrointestinal Tract Is Related to Intestinal Histological Subtype Not Tumour Location Mohammad H. Derakhshan, Sarah Liptrot, James Paul, Ian L. Brown, Kenneth E. McColl*

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED T2062

Comparison of Healing Rate of Artificial Ulcer After Endoscopic Submucosal Dissection in Relation to the Dose of Proton Pump Inhibitor. a Prospective Randomized Controlled Trial Seiji Kawano*, Hiroyuki Okada, Keisuke Hori, Daisuke Tanioka, Masahide Kita, Takao Tsuzuki, Masafumi Inoue, Satoru Yagi, Ryuta Takenaka, Masayuki Uemura, Yoshiro Kawahara, Kazuhide Yamamoto

T2063

Celecoxib Prevents Gastric Cancer in Helicobacter pyloriInfected Mice; Comparison with Nimesulide Ki-Baik Hahm*, Dae Yong Kim, Ki-Taek Nam, Hyun W. Baik

T2064

Clinicopathological Characteristics and Prognosis of Young Age Gastric Cancer: Analysis of 3,362 Consecutive Gastric Cancer Patients Jun chul Park*, Yong Chan Lee, Jie-Hyun Kim, Kyung Ho Song, Jae Jun Park, Yu Jin Kim, Sang Kil Lee, Woo jin Hyung, Sung Hoon Noh, Choong-Bai Kim, Jae Bock Chung

T2065

T2066

T2067

Overexpression of the Receptor Tyrosine Kinase Epha4 Plays An Important Role in the Progression of Human Gastric Cancers Nobuki Miyamoto*, Hiroyuki Yamamoto, Chie Miyamoto, Tadateru Maehata, Katsuhiko Nosho, Hiroaki Taniguchi, Kentaro Yamashita, Yasushi Adachi, Yoshiaki Arimura, Fumio Itoh, Kohzoh Imai, Yasuhisa Shinomura Endoscopic Mucosal Resection for Undifferentiated Intramucosal Gastric Cancer: Different Indications Between Signet Ring Cell Carcinoma and Poorly Differentiated Adenocarcinoma Hoi Jin Kim, Jae J Kim, Eun Ran Kim*, Dong Hyun Sinn, Young-Ho Kim, Jun Haeng Lee, Dong Kyung Chang, Poong-lyul Rhee, Jong Chul Rhee



Prospective Analysis of Metachronous Early Gastric Cancer in High Risk Patients After H. pylori Eradication Akiko Shiotani*, Noriya Uedo, Tomoari Kamada, Hiroyasu Iishi, Masaharu Tatsuta, Minoru Fujita, Ken-ichi Tarumi, Noriaki Manabe, Hiroaki Kusunoki, Ken Haruma

T2068

Incidence Rates of Esophageal and Gastric Carcinoma in Central Switzerland Within the Last 25 Years: There Is No Increase of the Incidence of Adenocarcinoma of the Gastroesophageal Junction Adrian Schmassmann*, Marie-Gabrielle Oldendorf, Jan-Olaf Gebbers

T2069

Role of Ciap2 in Gastric Cancer Zesong Li*, Liang Qiao, Yun Dai, Bing Zou, Juan Ma, HuiYao Lan, Benjamin C.Y. Wong

T2070

The Promoter Polymorphism of Nuclear FactorErythroid 2-Related Factor 2 (NRF2) Gene Affects the Aberrant Promoter Methylation of Tumor-Related Genes in Gastric Epithelium Tomiyasu Arisawa*, Tomomitsu Tahara, Tomoyuki Shibata, Masakatsu Nakamura, MItsuo Nagasaka, Yoshio Kamiya, Hiroshi Fujita, Daisuke Yoshioka, Masaaki Okubo, Yuko Arima, Hiroaki Shimazaki, Ichiro Hirata, Hiroshi Nakano

T2071

Clinicopathological Time Trends for Early Gastric Cancer and Helicobacter pylori Infection in Japan Naoko Tsuji*, Shingo Ishiguro, Yasuko Umehara, Masatoshi Kudo

T2072

Effectiveness of Gastric Endoscopic Submucosal Dissection (ESD) in Elderly Patients Yohei Koizumi*, Tomoyuki Ninomiya, Yasunori Yamamoto, Hirokazu Doi, Atsushi Hiraoka, Soichi Ichikawa, Aki Hasebe, Makoto Yano, Yasunao Miyamoto, Norio Horiike, Bunzo Matsuura, Morikazu Onji

T2073

Mucin Phenotype of Gastric Adenocarcinoma Reflects the Invasiveness of the Tumor Sun-Young Lee*, Hye Seung Han, Kyung Yung Lee, Sung Noh Hong, Jeong Hwan Kim, In Kyung Sung, Hyung Seok Park, Choon Jo Jin, Young Il Min

T2074

Progressive Expression of Angiopoietin-Like 4 (Angptl4) in Human Gastric Adenocarcinoma Toshiyuki Nakayama*, Yumi Mihara, Mitsuru Taba, Shiro Miura, Yuki Naruke, Maki Inaba, Hiroshi Hirakawa, Ichiro Sekine

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: MOLECULAR GENETICS: EPIGENETICS, MICROSATELLITE AND CHROMOSOMAL INSTABILITY Participants will be able to: • Review recent research in epigenetics, microsatellite and chromosomal instability. T2075



Comprehensive Analysis of Allelic Imbalance By Using High-Density Single Nucleotide Polymorphism (SNP) Array in Gastrointestinal Cancer Motohisa Tada*, Fumihiko Kanai, Yasuo Tanaka, Miki Ohta, Yoshinari Asaoka, Motoko Seto, Takao Kawabe, Osamu Yokosuka, Masao Omata

T2076

DNA Methylation Profiles Within Normal Human Colorectal Mucosa Are Gene Specific and Influenced By Region, Patient Age and Pathology Daniel L. Worthley*, Vicki Whitehall, Ron Buttenshaw, Justin R. Scott, Barbara A. Leggett

T2077

Hyperplastic Polyps and Sessile Serrated Adenomas As a Phenotypic Expression of MYH-Associated Polyposis (MAP) Karam S. Boparai*, Josbert J. Keller, Susanne van Eeden, Joep F. Bartelsman, Elisabeth M. Mathus-Vliegen, Evelien Dekker, Carel J. van Noesel

T2078

Relationship Between Laterally Spreading Type, JC Virus and Methylator Phenotype in Colorectal Adenoma Hiroyuki Yamamoto*, Katsuhiko Nosho, Nobuki Miyamoto, Chie Miyamoto, Tadateru Maehata, Hiroaki Taniguchi, Kentaro Yamashita, Yasushi Adachi, Yoshiaki Arimura, Fumio Itoh, Kohzoh Imai, Yasuhisa Shinomura

T2079

Frequency of Microsatellite Instability and Alterations of DNA Repair Systems in Non-Dysplastic Mucosa of Inflammatory Bowel Disease Patients Alfredo Papa*, Simona Guglielmo, Paola Fortini, Ida Casorelli, Federica Chiera, Gianluca Andrisani, Giammarco Mocci, Italia Roberto, Michele Bonizzi, Sara Ennas, Carla Felice, Italo De Vitis, Luisa Guidi, Giuseppe Fedeli, Antonio Gasbarrini

T2080

Long Term Follow-Up Study: The Reversibility of CpG Island Hypermethylation of Tumor-Related Genes in Non-Cancerous Patient and Gastric Carcinoma Patient After H. pylori Eradication Therapy Takuji Yamasaki*, Mitsuru Kaise, Jun Miwa, Jun Tashiro, Takashige Tomita, Yasuo Matsubara, Shunji Mishiro, Hisao Tajiri

T2081

Genetic and Epigenetic Alterations in Young, NonFamilial Colorectal Cancer Patients Woon-Tae Jung*, Takeshi Nagasaka, Ajay Goel, C. R. Boland

Denotes DDW Poster of Distinction

P-287

T U E S D A Y MAY 20

POSTER SESSIONS—COMBINED T U E S D A Y

T2082

Loss of IGF-2 Genomic Imprinting and Increased Risk of Colorectal Neoplasia Recurrence: A Prospective Cohort Study Marcia R. Cruz-Correa*, Hao Wang, Linda Hylind, Ronghua Zhao, Mariana Berho, Dana Sands, Eric G. Weiss, Juan Nogueras, Steven Wexner, Francis M. Giardiello

T2083

Mutations in Both KRAS and BRAF Contribute to the Methylator Phenotype in Colon Cancer Takeshi Nagasaka, Minoru Koi, Naoshi Nishida, Sung Kwan Shin, Nagahide Matsubara, C. R. Boland, Ajay Goel*

T2084

VEGF-a Levels and Lymphatic Vessel Density Are Reduced in Colorectal Cancers with Microsatellite Instability Teresa Herraiz*, Mari Mino-Kenudson, Maria S. Pino, Hirotoshi Kikuchi, Do-Youn Park, Antoni Castells, Cristina Alenda, Lawrence R. Zukerberg, Anthony J. Iafrate, Daniel Chung

MAY 20

T2085

T2086

Methylation Status of Background Normal Mucosa Is Correlated with Occurrence and Development of Neoplasia in the Distal Colon Sakiko Hiraoka*, Joichiro Horii, Jun Kato, Shunsuke Saito, Keita Harada, Hideyuki Fujita, Motoaki Kuriyama, Koji Takemoto, Toshio Uraoka, Kazuhide Yamamoto Hypermethylation of Multiple Genes in Intraductal Papillary Mucinous Neoplasm of Pancreas Seung-Mo Hong*, David J. Kelly, Noriyuki Omura, Ang Li, Chung-Pin Li, Ralph H. Hruban, Michael G. Goggins

T2087

DNA Hypermethylation Causes Cancer-Associated Changes of Carbohydrate Determinants By Silencing ‘Glyco-Genes' in Gastrointestinal Cancer Yuki I. Kawamura*, Minoru Toyota, Rei Kawashima, Teruki Hagiwara, Yutaka Kawamura, Taeko Dohi

T2088

P15 Hypermethylation Correlates with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma Philip W. Chiu*, Wai K. Leung, Angela M. Hui, Man Yee Yung, Bonnie Y. Tsung, Anthony Y. Teoh, Frances K. Cheung, Enders K. Ng

T2089



Genetic Instability Caused By Loss of Msh3 in Human Colorectal Cancer; the Molecular Basis of MSI-L and Emast Tumors Minoru Koi*, Ajay Goel, Thuy-Phuong T. Nguyen, C. R. Boland

T2090

CAN1 Gene Methylation Profile in African Americans with Colon Cancer and Adenoma, New Candidate Genes Krishan Kumar*, Mohammad Daremipouran, Pooneh Mokarram, Seyed Mehdi Nouraie, Edward L. Lee, Duane T. Smoot, Hassan Ashktorab

T2091

A Clinical-Pathological Predictive Model for the Identification of Colorectal Cancer with Mismatch Repair Deficit Cristina Alenda, Artemio Payá, Rodrigo Jover*

T2092

Distinct Cin and Min Pattern, CAN1 Gene Methylation Profile in African-Americans (AA) with Colon Cancer and Adenoma Hassan Ashktorab*, Mohammad Daremipouran, Hassan Brim, Krishan Kumar, Pooneh Mokarram, Narayan Shivapurkar, Seyed Mehdi Nouraie, Edward L. Lee, Duane T. Smoot

T2093

Microsatellite Instability (MSI), Hmlh1 Promoter Hypermethylation and BRAF Mutation Analysis in Sporadic Colorectal Cancers (Crcs) of Different Ethnic Groups in Israel Alex Vilkin*, Yaron Niv, Takeshi Nagasaka, Sarah Morgenstern, Zohar Levi, Zvi Fireman, Meishu Li, Flory Fuerst, Ajay Goel, C. R. Boland

P-288

T2094

Investigation of the Colorectal Cancer Susceptibility Region On Chromosome 8q24.21 in a Large German Patient Sample Clemens Schafmayer*, Stephan Buch, Henry Völzke Völzke, Jan H. Egberts, Bodo Schniewind, Mario Brosch, Andreas Ruether, Bence Sipos, Stephan Hellmig, Alexander Katalinic, Markus M. Lerch, Ulrich John, Ulrich R. Fölsch, Fred Faendrich, Holger Kalthoff, Michael Krawczak, Stefan Schreiber, Juergen Tepel, Jochen Hampe

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION II: COMBINED T2095

Assessment of “Gene-Environment” Interaction in Cases of Familial and Sporadic Pancreatic Cancer Theresa P. Yeo*, Ralph H. Hruban, Alison P. Klein, Kieran Brune, Charles J. Yeo

T2096

Natural Orifice Translumenal Endoscopic Surgery for Roux-en-Y Gastric Bypass: An Experimental Surgical Study in a Human Cadaver Model Monika E. Hagen*, Francois Pugin, Oliver J. Wagner, Paul Swain, Nicolas C. Buchs, Margherita Cadeddu, Priya A. Jamidar, Jean Fasel, Philippe Morel

T2097

A Novel System for Classifying Paraesophageal Hernias Tommy H. Lee*, Carlos Godinez, Stephen M. Kavic, Ivan M. George, George T. Fantry, Adrian E. Park



Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL CLINICAL AASLD Poster Session 8:00 AM - 5:00 PM

W1010

Efficacy and Tolerability of Peginterferon Alfa-2a (40KD) and Ribavirin in Genotype 4 Patients with Chronic Hepatitis C (cHC) Under Real Life Conditions Elmar Zehnter*, Stefan Mauss, Dietrich Hueppe, Stephan Kaiser, Klaus Boeker, Thomas Lutz, Renate Heyne, Christine John, Gero Moog, Andreas Schober, Rainer Pfaff, Andreas Zipf, Stefan A. Racky, Jueregn Lohmeyer, Bernd Bokemeyer, Birgit Kallinowski, Thomas Witthoeft, Ulrich Alshuth

W1011

Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) of Silymarin (SM) Following Chronic Dosing in Patients with Chronic Hepatitis C (HCV) Sarah J. Schrieber*, Tedi A. Soule, Zhiming Wen, Abdus S. Wahed, Philip C. Smith, Michael W. Fried, K. Rajender Reddy, Victor J. Navarro, Nezam Afdhal, Steven H. Belle, Josh Berman, Q. Liu, Edward Doo, Roy L. Hawke

Sails Pavilion San Diego Convention Center

HCV TREATMENT II W1000

W1001

Estimating the Likelihood of Sustained Virological Response in Chronic Hepatitis C (cHC) Therapy Stefan Mauss*, Dietrich Hueppe, Christine John, Joerg Goelz, Ulrike Meyer, Renate Heyne, Bernd Moeller, Ralph Link, Gerlinde Teuber, Slawomir Sworszt, Andreas Herrmann, Maria Spelter, Andreas Wollschlaeger, Hermann Steffens, Axel Baumgarten, Karl-Georg Simon, Nektarios Dikopoulos, Thomas Witthoeft The Role of Cholesterol On Sustained Virological Response (SVR) in the Treatment of Genotype-1 Infected Hepatitis C (cHC) Patients with Peginterferon Alfa-2a (PEG) and Ribavirin (RBV) Stefan Mauss*, Elmar Zehnter, Dietrich Hueppe, Stephan Kaiser, Klaus Boeker, Thomas Lutz, Renate Heyne, Christine John, Gero Moog, Andreas Schober, Rainer Pfaff, Andreas Zipf, Stefan A. Racky, Jueregn Lohmeyer, Bernd Bokemeyer, Birgit Kallinowski, Thomas Witthoeft, Ulrich Alshuth

W1012

Treatment of Hepatitis C Associated Severe Mixed Cryoglobulinemic Syndrome with Plasma Exchange Improves Tolerability and Response to Interferon-Based Therapy Todd Frederick*, Jamie Zagorski, Robert G. Gish, Jan C. Hofmann

W1013

Feasibility of Interferon-Beta Induction By Twice-Daily Administration Prior to the Standard Combination Therapy Using Pegylated Interferon-Alpha-2b Plus Ribavirin Toshiya Nakatani*, Eri Satani, Shinya Takeyama, Sanae Murata, Shinsaku Nagamatsu, Koji Hashimoto, Hideki Matsuo, Eiryo Kikuchi

W1002

Silibinin Is a Potent Antiviral Agent in Patients with Chronic HCV Infection Not Responding to Peginterferon/Ribavirin Therapy Thomas-Matthias Scherzer*, Harald Hofer, Maximilian Schoeniger-Hekele, Petra Steindl-Munda, Peter Ferenci

W1003

Cost-Effectiveness of Treating Hepatitis C in the Prison Population Jennifer A. Tan*, Tom A. Joseph, Sammy Saab

W1014

Sustained Virologic Response and Relapse Rates with Peginterferon Alfa-2b Plus Ribavirin in Clinical Trials Are Comparable to Those in Community-Based Studies Michael P. Manns*, Dietrich Hueppe, Paul Marotta, Stefan Mauss, Elmar Zehnter, Ira M. Jacobson, Chrispin Kambili

Treatment After Liver Biopsy in Patients with Hepatitis C Virus (HCV) and HIV Co-Infection Kavitha Gopal*, Pauline Suwandhi, Arkady Broder, Henry C. Bodenheimer, Albert D. Min

W1015

Analysis of Sustained Virological Response to Pegylated Interferon & Ribavirin Treatment in Compensated Cirrhosis Due to Hepatitis C Virus, Genotype 3 Infection Amna Subhan*, Wasim Jafri, Khalid Mumtaz, Saeed S. Hamid, Shahab Abid, Hasnain Shah, Nida Jafri, Javed Yakoob, Zubair Ahmed

W1016

Efficacy and Safety of Erythropoietin-Alfa On Naïve Patients with Chronic Hepatitis C and Genotype 1 Receiving Combination Therapy with Pegylated Interferon-Alfa 2b and Ribavirin Dagmary Purcell*, Doris H. Toro

W1004

W1005

HCV RNA At 12 Weeks After Treatment Can Predict Sustained Virologic Response in Chronic Hepatitis C Patients Treated with Pegylated Interferon and Ribavirin Sun Yang*, Joon Hyoek Lee, Geum-Youn Gwak, Moon Seok Choi, Kwang Cheol Koh, Seung Woon Paik, Byung Chul Yoo

W1006

The Cognitive Impairment By Interferon Treatment in Patients with Chronic Hepatitis C Hiroto Tanaka*, Hiroki Ueda, Masakazu Ichinose

W1007

Rapid Virologic Response to Peginterferon Alfa and Ribavirin Treatment of Chronic Hepatitis C Predicts Sustained Virologic Response and Relapse F. Fred Poordad*, Chrispin Kambili

AASLD Poster Session 8:00 AM - 5:00 PM

Outcome of Chronic Hepatitis C Patients Referred for Pre Therapy Psychiatric Evaluations Niranjan Arachchi*, Katherine L. Mellor, Sally Bell, Paul Desmond

VIRAL HEPATITIS: OTHER ASPECTS

W1008

W1009

Impaired Cardiovagal Autonomic Function At 12th Week of anti-HCV Treatment. a Follow-Up Study Janos Osztovits*, Tamas Horvath, Zsolt Visnyei, Timea Csak, Andrea Horvath, Peter L. Lakatos, Endre Ibranyi, Tamas Toth, Gabriella Lengyel, Janos Feher, Margit Abonyi, Peter Kempler, Mark Kollai, Ferenc Szalay

Sails Pavilion San Diego Convention Center

W1017

Clinical and Persistency Outcomes in Hepatitis C Patients Treated with Peginterferon Alfa-2a or Peginterferon Alfa-2b Plus Ribavirin Tarek Hassanein*, Xin Ye, Teng-Chiao Chu, Diana Brixner

W1018

A Prospective Study of the Diagnostic Accuracy of TRANSIENT ELASTOGRAPHY (Fibroscan®) in the Evaluation of Hepatic Fibrosis in Asians Compared with Liver Biopsy and APRI Jason Chang*, Hock-Foong Lui, Cora Chau, Kiat-Hon Lim, Wai-Ming Yap, Chee-Kiat Tan, Wan-Cheng Chow

Denotes DDW Poster of Distinction

P-289

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL W1019

Effects of Eltrombopag On Thrombopietin Levels During Antiviral Therapy in HCV Patients with Cirrhosis Nezam Afdhal*, John G. McHutchison, Fiona M. Campbell, James B. Bussel, Gregory Cheng, Nicole Blackman, Julian M. Jenkins, Dickens Theodore

W1030

W1020

Outcome of Murine Hepatitis Virus Strain 3-Induced Fulminant Hepatitis Is Regulated By CD4+Cd25+ Treg Production of Fgl2 Itay Shalev*, Kaylyn Kit Man Wong, Katharina Foerster, Yi Zhu, David A. Clark, M. J. Phillips, Gary A. Levy

AGA Institute Poster Session 8:00 AM - 5:00 PM

Chronic Hepatitis C Virus (HCV) Infection in a Cohort of Postmenopausal Irish Women Contributes to the Development of Bone Fractures Kavinderjit S. Nanda*, Elizabeth J. Ryan, Malachi McKenna, Jennifer Brady, Barbara F. Murray, Cliona O'Farrelly, John Hegarty

GASTROINTESTINAL INFLAMMATION

W1021

W E D N E S D A Y MAY 21

Minimally Invasive Oesophagectomy for Cancer Leads to Early Recovery of Health-Related Quality of Life Rajeev Parameswaran*, Jane M. Blazeby, Keith Mitchell, Richard G. Berrisford, Saj Wajed

Sails Pavilion San Diego Convention Center

Sponsored by: Clinical Practice

Participants will be able to: • Become familiar with clinical aspects to gastrointestinal inflammation. W1031



Cost Minimization Analysis Comparing Diagnostic Strategies in Unexplained Pancreatitis Charles M. Wilcox*, Meredith Kilgore

W1032

Economic Analysis and Outcomes of 10-Day Sequential Therapy Compared to 10-Day Triple Therapy for Helicobacter pylori (H. pylori) Eradication Nimish Vakil*, Angelo Zullo, Chiara Ricci, Dino Vaira

W1033



Seasonal Variation in the Incidence of Eosinophilic Esophagitis Over 30 Years: A Population Based Study Ganapathy A. Prasad*, Thomas C. Smyrk, Cathy Schleck, Alan R. Zinsmeister, G. Richard Locke, Jeffrey A. Alexander, Nicholas J. Talley

W1034

Ten-Year Follow Up Study On Acid-Related Disease After H. pylori Eradication Zhou Li-ya*, Yan Xiu-e, Lin San-Ren, Ding Shi-gang, Huang Yong-hui, Cui Rong-li, Jin Zhu, Zhang Li, Li Yuan, Meng Ling-mei, Zhang Jing

W1035



Very High Rate of Misdiagnosis of Celiac Disease in Practice Maria Ines Pinto Sanchez, Edgardo Smecuol, Roberto M. Mazure, Emilia Sugai, Horacio Vazquez, Sonia Niveloni, Eduardo Mauriño, Julio C. Bai*

W1036

Do Tissue Transglutaminase Antibodies in Celiac Disease Contribute to Thyroid Autoimmunity? Afzal J. Naiyer*, Jayesh Shah, Jianfeng Cheng, Lincoln Hernandez, Edward J. Ciaccio, John S. Manavalan, Govind Bhagat, Peter H. Green

W1037

Collagenous Colitis: Clinical Presentation, Treatment and Outcome of 287 Patients Ahmed Madisch*, Stephan Miehlke, Franziska Bartosch, Birgit Bethke, Manfred Stolte

CANCER DETECTION AND PREVENTION

W1038

Participants will be able to: • Apply techniques for early cancer detection and prevention into clinical practice.

From Intra- to Extra-Gastric Role of Helicobacter pylori: Implications On Metabolic Syndromes Mohammad Khaled

W1039

Helicobacter pylori Infection and Impaired Drug Absorption: A Systematic Review Edith Lahner, Bruno Annibale, Gianfranco Delle Fave*

W1040

Small Intestinal Bacterial Overgrowth and Oral Anticoagulant Therapy Emidio Scarpellini*, Maurizio Gabrielli, Angelo Santoliquido, Tommaso Za, Elena Rossi, Ernesto Cristiano Lauritano, Andrea Lupascu, Veronica Ojetti, Giovanni Cammarota, Giovanni Gasbarrini, Valerio De Stefano, Antonio Gasbarrini

W1041

Using Patient Narratives Improves Awareness and Knowledge of Celiac Disease Amongst Physicians Mohsin Rashid

W1022

W1023

W1024

W1025

W1026

Prevalence and Medical Resource Utilization in HCV Patients with Thrombocytopenia F. Fred Poordad*, Mehul R. Dalal, Kelly M. Grotzinger Prevalence of Hepatitis B Viral (HBV) Infection Among Hmongs in the San Joaquin Valley Muhammad Y. Sheikh*, Leepao Khang, Mouatou Mouanoutoua, Jayanta Choudhury, Steven Stoltz, Jasjit Singh, Mandeep Singh, Paul Mills Highly Prevalent ALT Abnormalities in Mycoplasma Pneumoniae Infection Sang Hoon Park*, Joo-Hee Kim, In Joung Lee, Taeho Hahn, Myung Kook Jang, Jin Bong Kim, Dong Jun Kim, Myung Seok Lee, Choong Kee Park Portal Tract Number Increases the Diagnostic Value of Ultrasound-Guided Percutaneous Liver Biopsies: A 3 Year Retrospective Review Dominic M. Taylor, Alexander C. Ford, Konstantinos Michalopoulos, Yasmine Kamal, Izabela B. Georgiades, Mark Kon, Sulleman Moreea* A Multimodal Educational Intervention Results in Organizational Changes in Hepatitis C Management: Results of a Controlled Trial Astrid Knott, Veena Choudary, Eric Dieperink, Judith Garrard, Janet Durfee, Mary J. Wingert, Samuel B. Ho*

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Clinical Practice

W1027



Epidemiology of Gastric MALT Lymphoma: A LongTerm Nationwide Study in the Netherlands Lisette G. Capelle*, Annemarie C. de Vries, Caspar W. Looman, Gerrit A. Meijer, M. K. Casparie, E. J. Kuipers

W1028

Fast-Track Services for Upper GI Cancer: Target: A Patient Screening Tool to Detect Delayed and Inappropriate ‘Two Week Rule' Referrals and a Survey of Family Practitioner Preferences for Service Organisation Guy Pritchard*, Neil Kapoor, Richard Sturgess, Keith Bodger

W1029



P-290

Development and Validation of a Simple Scoring System for Prediction of Lymph Node Metastases in Esophageal Cancer Gregory Zuccaro*, John J. Vargo, John A. Dumot, Tyler Stevens, Rocio Lopez, Thomas Rice

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL W1042



Clinical Outcomes of Acute Pancreatitis During Pregnancy Shou Jiang Tang*, Edmundo Rodriguez-Frias, Saad F. Jazrawi, Marlyn J. Mayo, Jayaprakash Sreenarasimhaiah, Luis F. Lara, Don C. Rockey

W1052

Metabolic and Cardiovascular Implications of a NonInvasive Based Classification in Non-Alcoholic Fatty Liver Disease Norberto Chavez-Tapia*, Felix I. Tellez-Avila, Francisco Sanchez-Avila, Misael Uribe

W1043

Microbiologic Diagnostic with the Novel Lightcycler Septifast® Test During the Early Phase of Surgical Sepsis Mainly Caused By Peritonitis Is Quicker and More Sensitive Than Conventional Microbiological Culture Uwe Lodes, Beate Bohmeier, Frank Meyer*, Brigitte Koenig, Hans Lippert

W1053

Inadequate Use of Proton-Pump Inhibitors in Patients with Liver Cirrhosis Evangelos Kalaitzakis*, Einar Bjornsson

W1054

“We Use the Needle, Do We Get the Point?” Contribution of Liver Biopsy to Patient Care M. Srinivas*, Pandurangan Basumani, Barbara Hoeroldt, Pierre J. Willemse, Karna Dev Bardhan

W1055

“As You Sow, SO You Reap” Liver Biopsy: Clinical Information in Histopathology Requests M. Srinivas*, Pandurangan Basumani, Barbara Hoeroldt, Pierre J. Willemse, Karna Dev Bardhan

W1056

Adequacy of Liver Biopsies: Variability Across Different Methods of Specimen Acquisition Rupert Abdalian*, Jenny Heathcote, Maha Guindi

W1057

Assessment of Hepatitis B Prior to Initiation of Chemotherapy in An Oncology Population At An Urban Teaching Hospital Nalini K. Sharma*, Biju K. Alex, Dana Sloane, Hiral Shah, Raman Battish, Averell H. Sherker

W1044

Racecadotril 175 Mg Tablet Bid Is More Efficient Than Racecadotril 100mg Capsule tid in the Treatment of Acute Diarrhea in Adults Yoram Bouhnik, Philippe Baumer*, Xavier Hebuterne

W1045

Efficacy of a New 175 Mg Bid Treatment By Racecadotril in Patients with Acute Diarrhea. MetaAnalysis of 2 Randomized Prospective Studies Benoit Coffin, Yoram Bouhnik, Philippe Baumer*

W1046

Effect of a New Bid Treatment By Racecadrotil in Adult Patients with Acute Onset Diarrhea, a Non-Inferiority Study Benoit Coffin, Philippe Baumer*

W1047

W1048

W1049

Metronidazole-Furazolidone-or, ClarithromycineFurazolidone-or, Clarithromycine-Based Regimen for Eradication of Helicobacter pylori in Peptic Ulcer Disease Saghi Riahizadeh, Shahram Agah, Nasrin Zendehdel, Reza Malekzadeh, Rasoul Sotoudehmanesh, Naser EbrahimiDariani, Homayoun Vahedi, Morteza Khatibian, Javad Mikaeli, Akram Pourshams, Sadegh Massarrat*

W1058

AGA Institute Poster Session 8:00 AM - 5:00 PM Sponsored by: Clinical Practice

Bismuth-Based Quadruple Therapy Is Effective in High Metronidazole Resistance Area Varocha Mahachai*, Sombat Treeprasertsuk, Ratha-korn Vilaichone

W1059



The Balance Between Severe Cardiovascular and Gastrointestinal Events Among Users of Selective and Non-Selective Non Steroidal Anti-Inflammatory Drugs Michiel W. van der Linden, Sjoukje Van der Bij, E. J. Kuipers*, Ron M. Herings

W1060

Hospitalizations for Gastrointestinal Events Among Users of COX-2 Inhibitors Compared with Traditional Non-Steroidal Anti-Inflammatory Drugs with ProtonPump Inhibitors Michiel W. van der Linden, E. J. Kuipers*, Myrthe P. Sukel, Ron M. Herings, Sabine Gaugris

W1061



Protective Effect of Nitrates On the Risk of Ulcer Bleedings Induced By Aspirin in Japan Chise Kodaira*, Takahisa Furuta, Mitsushige Sugimoto, Mihoko Yamade, Masafumi Nishino, Mutsuhiro Ikuma, Michio Kimura, Akira Hishida

W1062

Clinical Knowledge Gaps, Formative Training and Safer NSAID Prescription Gregory P. Gaspard*, Diana L. Castillo, Neena S. Abraham

W1063

Does Low-Dose Aspirin Therapy Affect the Results of Immunochemical Fecal Occult Blood Tests? Shin Ishikawa*, Jun Kato, Hideyuki Suzuki, Mitsuhiro Akita, Motoaki Kuriyama, Tsuyoshi Fujimoto, Manabu Kurome, Koji Takemoto, Toshio Uraoka, Kazuhide Yamamoto

W1064

Health Literacy Among Patients Taking NSAIDs and Proton Pump Inhibitors Eric H. Choi*, Pouya Afshar, Walter Coyle

NSAIDS AND THE GI TRACT Participants will be able to: • Understand the mechanisms of NSAIDs and the GI tract.

Sails Pavilion San Diego Convention Center

Sponsored by: Clinical Practice

LIVER DISEASES Participants will be able to: • Become familiar with clinical aspects to liver disease.



Impact of Alcohol Abuse and Dependence On Liver Fibrosis in a Prospective Cohort of 6090 HIV+/Hiv- U.S. Veterans Joseph K. Lim*, Shawn L. Fultz, Joseph L. Goulet, Joseph Conigliaro, Kendall J. Bryant, Adam J. Gordon, Cynthia L. Gibert, David A. Fiellin, Amy C. Justice

W1051

A Comparison of Outcome Predictive Scores for Acute Haemorrhage from Oesophageal Varices Paul Dunckley*, Neil Rajoriya, Katharine Tweed, Jonathan Booth



Sails Pavilion San Diego Convention Center

Low Efficacy of PPI/AC Therapy for H. pyloriEradication in Japan Takashi Kawai*, Tetsuya Yamagishi, Kenji Yagi, Mikinori Kataoka, Kouhei Kawakami, Atsushi Sofuni, Takao Itoi, Yoshihiro Sakai, Fuminori Moriyasu, Yu Takagi, Tatsuya Aoki, Emiko Rimbara, Norihisa Noguchi, Masanori Sasatsu

AGA Institute Poster Session 8:00 AM - 5:00 PM

W1050

Psychological Distress in Patients with Liver Cirrhosis Evangelos Kalaitzakis*, Axel Josefsson, Einar Bjornsson

Denotes DDW Poster of Distinction

P-291

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL W1065

Knowledge of Risk Factors for NSAID-Related Upper GI Complications and Role of Gastroprotection Among Senior Resident Physicians Gregory A. Cote*, Fabiolla Siqueira, John P. Rice, Colin W. Howden

AGA Institute Poster Session 8:00 AM - 5:00 PM

W1076

How the Duration of Dyspeptic Symptom Affect the Therapeutic Approaches. Experience from Japanese Mega Study (Jmms) Koji Nakada*, Michio Hongo, Shigeru Harasawa, Tetsuya Mine, Iwao Sasaki, Kei Matsueda, Motoyasu Kusano, Nobuyoshi N. Hanyu, Chikashi Shibata

W1077

The Long-Term Effect of Helicobacter pylori Eradication Therapy On Dyspepsia Symptoms in Industrial Workers in Japan Yukinao Yamazaki*, Ikumi Yoshida, Akiyo Yamakawa, Hidetaka Matsuda, Takashi Ohno, Ryuho Masaki, Satoko Satomi, Masahiro Ohtani, Hiroyuki Suto, Yoshiyuki Ito, Takuji Kato, Takeshi Azuma

W1078

High Prevalence of Helicobacter pylori Infections By Multiple Strains in Patients with Dyspepsia from a Developing Country Shahab Abid*, Javed Yakoob, Wasim Jafri, Khalid Mumtaz, Nida Jafri, Zaigham Abbas, Hasnain Shah, Saeed S. Hamid, Rashida Ahmed

W1079

Curcumin Vs Domperidon in Functional Dyspepsia: Better the Prokinetic or An Agonist of Vanilloid Receptor? Antonio Nouvenne, Andrea Maini, Lucas Giovanni Cavallaro, Roberta Merli, Loredana Guida, Ester Morana, Margherita Curlo, Andrea Iori, Laura Martelli, Mario Martelli, Giulia Martina Cavestro, Iva Pelosini, Carmelo Scarpignato, Angelo Franzè, Francesco Di Mario*

W1080

The Accuracy and Predictors of a Clinical Diagnosis of Dyspepsia or Peptic Ulcer Disease By Gastroenterologists and Family Practitioners Nimish Vakil*, John Dent, Roger Jones, Tore Lind, Ola Junghard

W1081

Non-Digestible Capsule Technology to Measure Gastric Motility- Comparison Between Healthy Controls and Gastroparetic Patients with a Normal Gastric Empyting Study Savio Reddymasu*, Irene Sarosiek, Henry P. Parkman, Kenneth L. Koch, Michael D. Sitrin, John M. Wo, William L. Hasler, Leonard A. Katz, William D. Chey, Jack Semler, Braden Kuo, Richard McCallum

W1082

Lack of Discriminant Value of Dyspepsia Subgroups According to the ROME III Consensus in Dyspeptic Patients On Acid-Suppressive Therapy Referred for Upper Gastrointestinal Endoscopy Sebastien Kindt, Joris Arts, Stefan Bourgeois, Christophe Claessens, Philip Caenepeel, Lieselot Holvoet, Dominiek De Wulf, Raf Bisschops*, Gert A. Van Assche, Severine Vermeire, Jan F. Tack

W1083

Is Therapeutic Response to Esomeprazole in Patients with Uninvestigated Dyspepsia Sustainable During Sixteen Weeks of Therapy: Its Potential Clinical Implication? Irene Sarosiek, Katherine Roeser, Stanley A. Edlavitch, Richard McCallum, Jerzy Sarosiek*

W1084

Rabeprazole vs. Itopride; a Randomized Multicenter Trial to Determine Efficacy in Functional Dyspepsia in Japan Takeshi Kamiya*, Makoto Hirako, Michiko Shikano, Tsutomu Mizoshita, Takaya Shimura, Eiji Kubota, Tsuneya Wada, Hiromi Kataoka, Makoto Sasaki, Takashi Joh

W1085

Functional Dyspepsia: Are Relapse Rates Influenced By Active Treatment? Ulrike von Arnim*, Bettina R. Vinson, Peter Malfertheiner

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

DYSPEPSIA

W E D N E S D A Y MAY 21

Participants will be able to: • Discuss recent developments in the treatment of dyspepsia. W1066

Reduced Gastric Accommodation in Non-Ulcer Dyspepsia (NUD) Lasts At Least 2 Hours: Studies By Simultaneous Gastric Volume and Emptying Measurements H. Jae Kim*, Michael Roarke, Michael Camilleri, Michael D. Crowell, Chris D. Tollefson, Michael S. Lee, Duane D. Burton, Alan R. Zinsmeister, Virender K. Sharma, Ananya Das

W1067

Sustained Beneficial Effect of a Gluten Free Diet in Dyspeptic Patients with Lymphocytic Enteritis Without Villous Atrophy Ivar M. Harkema*, Jan H. Kleibeuker, Jeroen J. Kolkman

W1068

Discriminant Value of Dyspepsia Subgroups According to the ROME III Consensus in Dyspeptic Patients Referred for Upper Gastrointestinal Endoscopy Joris Arts, Stefan Bourgeois, Christophe Claessens, Philip Caenepeel, Dominiek De Wulf, Lieselot Holvoet, Raf Bisschops, Gert A. Van Assche, Severine Vermeire, Jan F. Tack*

W1069

Role of Serine Protease Signaling in Dyspeptic Symptom Generation; a Pilot Study Ofke S. van Boxel*, Jose ter Linde, Niels van Lelyveld, Peter D. Siersema, André Smout

W1070

Estimation of the Minimum Clinically Important Difference (Mcid) for the Nepean Dyspepsia Index (Ndi), a Validated Quality of Life (QOL) Scale for Functional Dyspepsia Mike Jones*, Nicholas J. Talley

W1071

W1073

W1074

W1075

P-292

Novel Associations with Dyspepsia: A Community Based Study Nicola Gathaiya*, E. Janet Castillo, G. Richard Locke, Michael Camilleri, Cathy Schleck, Alan R. Zinsmeister, Nicholas J. Talley Analysis of the Predictive Value of Alarm Symptoms in the Diagnosis of Gastric Malignancy in the Presence of Gastric Ulceration Ophelia K. Veraitch*, Constantine Alifrangis, Mohamed Shariff, Paul M. Trembling, Anil Goburdhone, Tahreema N. Matin, Rakesh Chaudhary, John P. Martin, Geoff Smith, Andrew V. Thillainayagam, Devinder S. Bansi Determinants of Bloating Severity: Symptomatic and Psychosocial Factors Influencing the Impactfullness of Bloating Michael P. Jones*, Jason Bratten, Sarah Umar, Laurie Keefer, Michael D. Crowell Intolerance to Volume Load in Drink Test and Psychiatric Distress Enhance the Severity of Daily Dyspeptic Symptoms in Functional Dyspepsia Koji Nakada*, Motohiro Ozone, Shigeru Harasawa, Naruo Kawasaki, Tomoko Nakayoshi, Nobuyoshi N. Hanyu, Hideyuki Kashiwagi, Katsuhiko Yanaga

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL AGA Institute Poster Session 8:00 AM - 5:00 PM

W1097

Muc4: A Potential Tumor Suppressor Gene in Colon Carcinogenesis Dhananjay Kunte*, Surinder K. Batra, Thomas C. Smyrk, Ramesh K. Wali, Jennifer Koetsier, Geoffrey Kraker, Hemant K. Roy

W1098

Curcumin Synergistically Potentiates the Inhibitory Effect of Sulindac Sulfone in Colon Cancer (CRC) Cells Nis Giladi, Diana Kazanov, Sarah Kraus, Ehud Ron, Ilan Aroch, Nadir Arber*

W1100

Uncoupling of EGFR-Snail Axis in Resistant Tumors During Polyethylene Glycol-Mediated Colon Cancer Chemoprevention Ramesh K. Wali*, Dhananjay Kunte, Jennifer Koetsier, Geoffrey Kraker, Hemant K. Roy

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: PREVENTION AND CHEMOPREVENTION Participants will be able to: • Review recent research in prevention and chemoprevention. W1086

Metformin Suppresses the Colorectal Carcinogenesis Via Activating AMP Protein Kinase in the Mouse Model Kaori Suzuki*, Hiroki Endo, Atsushi Nakajima

W1087

A Selective Cyclooxygenase-2 Inhibitor, Etodolac, Suppresses Stomach Carcinogenesis After Eradication Therapy of Helicobacter pylori in Mongolian Gerbils with Intestinal Metaplasia Hirohito Magari*, Kimihiko Yanaoka, Toru Niwa, Hisanobu Deguchi, Takayuki Kanno, Tatsuya Shiraki, Chizu Mukoubayashi, Izumi Inoue, Takao Maekita, Mikitaka Iguchi, Hideyuki Tamai, Kenji Arii, Masashi Oka, Masao Ichinose

W1088

W1090

W1091

Chemical Intervention Reverses Oxidative StressInduced Epigenetic Alterations in Colon Cancer Cells: Clues for New Chemopreventive Measures Against Aging and Carcinogenesis Masahiko Tsujii*, Shingo Tsuji, Hiroshi Eguchi, Shusaku Tsutsui, Hideki Iijima, Yoshimi Kakiuchi, Tsutomu Nishida, Kenji Watabe, Satoshi Egawa, Shinichiro Shinzaki, Shuji Ishii, Sachiko Nakajima, Toshiyuki Yoshio, Jumpei Kondo, Yoshito Hayashi, Yujiro Hayashi, Toru Nakamura, Sunao Kawano, Norio Hayashi Combination of Sulindac and H. pylori Eradication Prevents Progression of Gastric Cancer in Hypergastrinemic Ins-Gas Mice Chung-Wei Lee*, Arlin B. Rogers, Barry H. Rickman, Timothy C. Wang, James G. Fox Increased Cyclooxygenase-2 Expression in Juvenile Polyposis Syndrome W. Arnout van Hattem*, Lodewijk Brosens, Ari Ristimäki, Francis M. Giardiello, Johan Offerhaus

W1092

Chemopreventive Effects of Angiotensin Converting Enzyme Inhibitors On Rat Colon Carcinogenesis After 1,2-Dimethylhydrazine Initiation Sergio B. Garcia*, Aline Turatti

W1093

Helicobacter pylori Eradication Reduces the Incidence of Gastric Cancer: Results of a Systematic Review of Randomized Controlled Trials Paul Moayyedi*, Richard H. Hunt, Alexander C. Ford, Nicholas J. Talley, David Forman

W1094

W1095

W1096

NSAIDs Increase Gadd45a Expression in Colon Cancer Cells: A Novel Mechanism of NSAID-Induced Colon Cancer Cell Apoptosis Shiun-Kwei Chiou Calcitriol (1,25-Dihydroxyvitamin D3) and Dietary Calcium Induce Distinct Molecular Changes and Opposite Cellular Responses in Colonic Crypts Hyperplasia Shahid Umar, Joseph H. Sellin, Sara Peleg* Advanced Colorectal Neoplasia Following Polypectomy: A Pooled Analysis Maria Elena Martinez*, Arthur Schatzkin, John A. Baron, Douglas J. Robertson, David A. Lieberman, Ann G. Zauber, Sidney J. Winawer, Ruiyun Jiang, Dennis Ahnen, Elizabeth T. Jacobs, Stephanie Smith-Warner, David S. Alberts, E. Robert Greenberg

W1101

Differential Effects of 5-ASA Derivatives 4-ASA, 3-ASA and N-Acetyl-5-ASA On Cell Cycle and Replication Fidelity in Colon Epithelial Cells Gloria Luciani*, Christoph Campregher, Peter Biesenbach, Christoph Gasche

W1102

Mesalamine Modulates Several Genes Related to Carcinogenesis, Inflammation, and Cell Cycle Pathways Koushik K. Das*, Manisha Bajpai, Hao Liu, Kiron M. Das

W1103

Aberrant Crypt Foci (ACF): Detection, Genetic Abnormalities, and Clinical Applications Tetsuji Takayama*, Yoshiro Niitsu

W1104

The Influence of Genetic Variation in the Cytochrome P450 2c9 Enzyme in a Randomized Trial of Celecoxib for the Prevention of Sporadic Colorectal Adenoma Andrew T. Chan*, Ann G. Zauber, Craig J. Eagle, Meier Hsu, Rebecca B. Rosenstein, Ernest T. Hawk, Monica M. Bertagnolli

W1105



Suppression of Colon Cancer By Selenium-Enriched Milk Proteins: Enhanced Apoptotic Response to Carcinogen Is Associated with Reduction in Frequency of K-RAS Mutations Ying Hu*, Graeme H. McIntosh, Richard K. Le Leu, Graeme P. Young

W1106

Preventive Effect of Etdolac, a Selective Cyclooxygenase2 Inhibitor, On Cancer Development in Extensive Metaplastic Gastritis, a Helicobacter pylori-Negative Precancerous Lesion Kimihiko Yanaoka*, Masashi Oka, Hisanobu Deguchi, Toru Niwa, Chizu Mukoubayashi, Izumi Inoue, Hirohito Magari, Takao Maekita, Mikitaka Iguchi, Hideyuki Tamai, Kenji Arii, Masao Ichinose

W1107

Folate Supplementation in Rats Reduces GastroEsophageal Reflux Induced Hyperproliferative Esophagitis Carlos A. Menezes*, Pramod Bonde, Zarina Bell, Christine Swarbrick, Graeme O'Hara, Margaret Hoper, Kourosh Khosraviani, Frederick C. Campbell, Jim McGuigan

W1108

The Effects of Diet On Aberrant Crypt Foci Formation in Azoxymethane-Treated Rats Chenggong Yu*, Jun Yang, Li Gong, Han Wu

W1109

In Vitro and In Vivo Inhibition of Colorectal Cancer (CRC) Cell Growth By 2-14, a Novel Derivative of 5Aminosalycilic Acid Carmine Stolfi*, Daniele Fina, Roberta Caruso, Flavio Caprioli, Massimiliano Sarra, Massimo C. Fantini, Angelamaria Rizzo, Francesco Pallone, Giovanni Monteleone

W1110

Mesalazine Improves Replication Fideltiy At Microsatellites Irrespective of Sequence and Length of the Nucleotide Repeat Christoph Campregher*, Clemens Honeder, Christoph Gasche



Denotes DDW Poster of Distinction

W E D N E S D A Y MAY 21

P-293

POSTER SESSIONS—CLINICAL W1111

Effect of α-Difluoromethylornithine (DFMO) On Histopathology, Mucosal Polyamines,and Gene Expression Profiles in Patients with Dysplastic Barrett's Epithelium Frank A. Sinicrope*, Nina Joshi, Eugene Gerner, Bruce W. Morlan, Patrick M. Lynch, Ilan Kirsch, Russell Broaddus

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

Participants will be able to: • Learn more about complications and outcomes. W1120

Inflammatory Bowel Disease and Pregnancy: Preliminary Results of An European Multicenter Prospective CaseControl Study. On Behalf of Ecco (European Cohn's and Colitis Organization Aurora Bortoli

W1122

Serology Testing, Genotype, and Other Risk Factors for Repeat Ileocolic Resection in Crohn's Disease: A Timeto-Event Analysis Christian D. Stone*, Jiajing Chen, Jonathan T. Unkart, Elizabeth Gorbe, Casey K. McCullough, Steven R. Hunt, Candace R. Miller, Anne M. Bowcock, Ellen Li, David W. Dietz

W1123

Rigorous Histopathologic Assessment of the Colectomy Specimen for Features of Indeterminate Colitis (IC) Does Not Predict Outcome After Ileal Pouch-Anal Anastomosis (IPAA) Gil Y. Melmed*, Hanlin L. Wang, Eric A. Vasiliauskas, Marla C. Dubinsky, Andrew Ippoliti, Dermot P. McGovern, Stephan R. Targan, Phillip Fleshner

W1124

Management of Female Fertility and Pregnancy Following Restorative Proctocolectomy Julie A. Cornish*, Richard Lovegrove, Baljit Singh, Emile Tan, Neil Mortensen, R. J. Nicholls, Sue K. Clark, Paris P. Tekkis

W1125

A Study of Quality of Life, Sexual, Urinary and Faecal Function in Females Following Restorative Proctocolectomy Julie A. Cornish*, Katherine Wooding, Emile Tan, Ralph. J. Nicholls, Sue K. Clark, Paris P. Tekkis

W1126

Cost-Effectiveness of Natalizumab in Crohn's Disease Patients Who Have Failed Anti-TNF Alpha Therapy Bruce E. Sands*, Douglas C. Wolf, Sumeet Panjabi, Timothy Niecko, Steven Hass, Loretto Lacey, Mike Spencer

W1127

Clinical Outcome Following Immunomodulator Therapy in Pediatric Ulcerative Colitis (UC): Results from a Prospective Multicenter Inception Cohort Athos Bousvaros*, Trudy Lerer, James Markowitz, Anne M. Griffiths, David Keljo, Neal S. LeLeiko, David R. Mack, Jonathan Evans, Marian D. Pfefferkorn, Anthony R. Otley, Subra Kugathasan, Joel R. Rosh, Ryan S. Carvalho, M. Susan Moyer, Marsha H. Kay, Petar Mamula, Benny Kerzner, Wallace Crandall, Jeffrey S. Hyams

W1128

Extra-Intestinal Manifestations of Pediatric Inflammatory Bowel Disease Jennifer L. Dotson*, Jeffrey S. Hyams, James Markowitz, Neal S. LeLeiko, David R. Mack, Jonathan Evans, Marian D. Pfefferkorn, Anne M. Griffiths, Anthony R. Otley, Athos Bousvaros, Subra Kugathasan, Joel R. Rosh, David Keljo, Ryan S. Carvalho, M. Susan Moyer, Petar Mamula, Marsha H. Kay, Benny Kerzner, Christine R. Langton, Wallace Crandall

W1129

Impact of Decreased Quality of Life in Inflammatory Bowel Disease Patients On Disease-Related Behavior Judith E. Baars*, Zuzana Zelinkova, Peter B. Mensink, Tineke Markus, E. J. Kuipers, Christien J. van der Woude

APPLIED THERAPEUTICS/ NOTES Participants will be able to: • Become familiar with current endoscopic instrumentation and its application and limitations to natural orifice trans-luminal endoscopic surgery (NOTES). W1112



Efficacy of a Reverse Phase Polymer As a Submucosal Injection Solution for EMR: A Comparative Study Gloria Fernandez-Esparrach*, Sohail N. Shaikh, Arielle J. Cohen, Michele B. Ryan, Christopher C. Thompson

W1113

Use of the Smartpill GI Monitoring System to Estimate Whole Gut Transit Time Sabba Maqbool*, Henry P. Parkman, Steven Gelone, Frank K. Friedenberg

W1114



Magnetic Retraction for NOTES Cholecystectomy in the Human Cadaveric Model Marvin Ryou*, Christopher C. Thompson

W1115

Endoscopic Foreign Body Removal for Treatment of Chronic Abdominal Pain in Post Roux-en-Y Gastric Bypass Patients Owen Mogabgab, Marvin Ryou*, Christopher C. Thompson

W1116

Double Balloon Enteroscopy: A Preliminary Experience in Patients with Obscure GI Bleeding; Correlation of Findings with Capsule Endoscopy and Impact of Therapeutic Interventions On Transfusion Requirements Michael R. Fine*, Laurel Fisher, Mimi S. Takami

W1117

Projected Impact of NOTES On Patient Throughput, Resource Utilization, and Physician Reimbursement: Results of a Hypothesis-Generating Discrete-Event Queuing Model Matthew D. Solomon*, Jerry O. Jacobson, Eric Esrailian, Brennan M. Spiegel

W1118

Air and Fluid Leak Tests Post NOTES Procedures: A Pilot Study in a Live Porcine Model Xavier Dray*, Kathleen Gabrielson, Jonathan M. Buscaglia, Eun Ji Shin, Samuel A. Giday, Vihar C. Surti, Lia R. Assumpcao, Michael R. Marohn, Priscilla Magno, Laurie J. Pipitone, Susan K. Redding, Sergey V. Kantsevoy

W1119

Effective Ablation of Ecstatic Vessels Using Radiofrequency Energy Ablation for Bleeding from Chronic Radiation Proctitis As Imaged Using Endoscopic Optical Coherence Tomography Yu Chen, Chao Zhou, Desmond C. Adler, Tsung-Han Tsai, Joseph M. Schmitt, James Fujimoto, Hiroshi Mashimo*

MAY 21

P-294

Sails Pavilion San Diego Convention Center

COMPLICATIONS AND OUTCOMES II

Sails Pavilion San Diego Convention Center

Sponsored by: Imaging & Advanced Technology

W E D N E S D A Y

AGA Institute Poster Session 8:00 AM - 5:00 PM

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL W1130

W1131

W1132

W1133

Infliximab Does Not Increase Short-Term Post-Operative Infectious Complications in Patients with Ulcerative Colitis Marc Ferrante*, Séverine Vermeire, Sarah Declerck, Andre D'Hoore, Gert A. Van Assche, Ilse Hoffman, Isabelle Cleynen, Ingrid Arijs, Marie Joossens, Nathalie Vermeulen, Freddy Penninckx, Paul Rutgeerts

AGA Institute Poster Session 8:00 AM - 5:00 PM

Maintenance Therapy with Azathioprine (AZA)/6Mercaptopurine (6-MP) in Crohn'sDisease (CD) Reduces the Risk of RE-Operation Particularly in Smokers Pavol Papay*, Walter Reinisch, Elien Ho, Cornelia Gratzer, Donata Lissner, Wolfgang Miehsler, Clemens Dejaco, Harald Vogelsang, Gottfried Novacek

DIAGNOSTICS AND DISEASE ASSESSMENT II

A 3-Week Course of 80 Mg Weekly Administered Adalimumab As a Rescue Therapy for Patients with Crohn's Disease Who Lost Response to 40 Mg Weekly: Relationship with Adalimumab Trough Serum Levels Konstantinos Karmiris*, Maja Noman, Gilles Paintaud, Marc Ferrante, Anne-Claire Duveau, Danielle Degenne, Gert A. Van Assche, Severine Vermeire, Paul Rutgeerts Mucosal Healing Predicts Sustained Clinical Remission in Early Crohn's Disease Filip J. Baert*, Liesbeth Moortgat, Gert A. Van Assche, Philip Caenepeel, Philippe L. Vergauwe, Martine De Vos, Pieter C. Stokkers, Daniel W. Hommes, Severine Vermeire, Paul J. Rutgeerts, Brian Feagan, Geert D'Haens

W1134

The Vwf (Voting with Their Feet) Endpoint in Ulcerative Colitis Clinical Trials Reflects Clinical Practice Outcomes Sujal Rangwalla*, Akbar K. Waljee, Peter D. Higgins

W1135

High Incidence of Osteoporosis in Patients Over 50 Following Restorative Proctocolectomy Suggests Need for Routine Dxa Screening Simon D. McLaughlin*, Zarah L. Perry-Woodford, Matthew W. Johnson, Sue K. Clark, Paris P. Tekkis, Paul J. Ciclitira, Ralph. J. Nicholls

W1136

Fear and Fertility in Inflammatory Bowel Disease - A Mismatch of Perception and Reality Affects Patient Behaviour Reme E. Mountifield*, Ruth Prosser, Peter A. Bampton, Jane M. Andrews

W1137

Pregnancy and Neonatal Outcomes and Complications in Preclinical Inflammatory Bowel Disease Ugonna Iroku*, Brian P. Bosworth, Ellen J. Scherl

W1138

A Nationwide Multicenter Study On Venous Thromboembolism in Inflammatory Bowel Disease Gottfried Novacek*, Anna Sobala, Wolfgang Petritsch, Thomas Haas, Thomas Feichtenschlager, Herbert Tilg, Wolfgang Tillinger, Walter Reinisch, Peter Knoflach, Harry Fuchssteiner, Arthur Kaser, Andreas Mayer, Clemens Dejaco, Alfons Schmid, Reingard Platzer, Bernhard Jaritz, Harald Vogelsang

W1139

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

Participants will be able to: • Become familiar with disease assessment. W1140

Differentiation Between Ulcerative Colitis and Crohn's Disease Based On Longitudinal Measurement of Interferon-Gamma Inducible CXCL10 Chemokine Serum Levels Wahaj Zaidi*, Lawrence J. Saubermann, Victor M. Morales, Keely R. Parisian, Gianni Harris

W1141

Evaluation of a Novel Fecal Marker- Fecal Tumor Pyruvate Kinase Type M2 (M2-PK) and Its Comparison with Calprotectin in Patients with Inflammatory Bowel Disease: A Prospective Multicenter Study Yogesh Shastri*, Nada Povse, Oliver Schröder, Jürgen Stein

W1142

Clinical Use of Trasabdominal US for Ulcerative Colitis: Comparison with Colonoscopic Findings Hideharu Okanobu*, Tomotaka Tanaka, Abbi Saniabadi, Toshihide Ohya

W1143

A Novel Application of Calprotectin to Predict Colonic Histology in Patients with Inflammatory Bowel Disease Neal J. Schamberg*, Subha V. Sundararajan, Stevan A. Gonzalez, Ellen J. Scherl, Brian P. Bosworth

W1144

Comparison Between Techniques Providing the Luminal vs Extraluminal Surface in Assessing Crohn's Disease Recurrence: A Prospective Longitudinal Study Sara Onali, Emma Calabrese, Carmelina Petruzziello, Francesca Zorzi, Marta Cossignani, Giovanna Condino, Giuseppe Sica, Francesco Pallone, Livia Biancone*

W1145

Validation of An Algorithm for Predicting IBD, CD and UC in a Comprehensive Population: The Effect of Patient Age On Prediction Accuracy Gary R. Lichtenstein*, Bruce Neri, Augusto Lois

W1146

Novel Biomarkers of Ulcerative Colitis Activity: A Comparison of Urinary PGE-M, Fecal Calprotectin and C- Reactive Protein (CRP) Levels David Schwartz*, Brad Maltz, Christopher Slaughter, Ginger L. Milne, Stephanie C. Sanchez, Jason Morrow, Alexander A. Parikh, Nipun Merchant

W1147

Validation of the Interactive Voice Response System Administration of the Short Inflammatory Bowel Disease Questionnaire Manuel Y. Lam*, Hang Lee, Renee Bright, Bruce E. Sands

W1148

Home Telemanagement for Patients with Ulcerative Colitis (UC Hat) Raymond K. Cross*, Nadia Cheevers, Kathryn Lambert, Allison G. Steele, Paul Stozhkov, Joseph Finkelstein

W1149

Role of Fecal Polymerase Chain Reaction in the Differentiation of Intestinal Tuberculosis from Crohn's Disease Sucharita p. Chittaranjan, Ramadass Balamurugan, Balakrishnan S. Ramakrishna*

Fistula Associated Carcinoma in Crohn's Disease Anna Sobala, Friedrich Herbst, Gottfried Novacek, Harald Vogelsang*

Denotes DDW Poster of Distinction

P-295

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL AGA Institute Poster Session 8:00 AM - 5:00 PM

W1162

Corticosteroids Increase Interleukin-10 and Inhibit Interleukin-12p40 Production By Intestinal Dendritic Cells in Acute Ulcerative Colitis - Novel Mechanisms of Therapy Siew C. Ng*, Sophie Plamondon, Hafid O. Al-Hassi, Michael A. Kamm, Stella C. Knight, Andrew J. Stagg

W1163

Activin Signaling in Experimental Colitis You-Qing Zhang*, Kim E. Barrett, Nora Sarvetnick

W1164

Role of Tank for Inhibition of TNF Induced Nf-κB Activation in Intestinal Macrophages (Imac) Heidi Piberger*, Katja Schreiter, Isabelle Frey, Silvia Kellermeier, Michael Fried, Jurgen Scholmerich, Gerhard Rogler

W1165

IL-1β-Induced Expression of Matrix-Metalloproteinase-1 Is Dependent Upon Acid Sphingomyelinase Jessica Bauer*, Christian Huy, Julia Brenmoehl, Juergen Schoelmerich, Florian Obermeier, Jürgen Bock

W1166

Neutralization of Tumor Necrosis Factor Suppresses the Development of Colitis-Associated Tumor in Mice Michio Onizawa*, Takashi Nagaishi, Yasuhiro Nemoto, Shigeru Oshima, Ryuichi Okamoto, Teruji Totsuka, Takanori Kanai, Hideo Yagita, Mamoru Watanabe

W1167

Activation and Modulation of the MAP Kinase Pathway in IBD Guillermo H. Docena, Aine Fanning, Laura Rovedatti, Antonio Di Sabatino, Nicholas A. Leakey, Charles H. Knowles, Kevin Lee, Fergus Shanahan, Kenneth Nally, Peter McLean, Thomas T. MacDonald, Laurens Kruidenier*

W1168

A Key Role for the Endocannabinoid System in Dampening T Helper Cell Type 1 Response in Inflammatory Bowel Disease Antonio Di Sabatino*, Natalia Battista, Paolo Biancheri, Paolo Cazzola, Alessandro Vanoli, Laura Rovedatti, Giuseppe Astarita, Daniele Piomelli, Thomas T. MacDonald, Mauro Maccarrone, Gino R. Corazza

W1169

IL-15 and IL-15 Soluble Receptor in Crohn's Disease Active Patients Before and After Infliximab Treatment Arnaud Bourreille*, Gregory Bouchaud, Erwan Mortier, Ariane Plet, Jean Paul Galmiche, Yannick Jacques

W1170

CXCL10 Expression and Biological Activities in Inflammatory Bowel Disease Alison Witte*, Michelle R. Kuhne, Benjamin T. Preston, Steven R. Wallace, Sharline Chen, Geetha Vasudevan, Michael Yellin, Kiron M. Das, Pina M. Cardarelli

W1172

Effect of Certolizumab Pegol and Conventional AntiTnfs On Reverse Signaling of Membrane TNF in Human Monocytes Gianluca Fossati, Adam Platt, Sharon Doughty, Andrew M. Nesbitt*

W1173

An In Vivo Study to Evaluate MLCK Expression in Patients with Inflammatory Bowel Diseases Roberta Fedele*, Rocco Spagnuolo, Paola Cosimo, Giovanna Ruggiero, Vincenzo Cosco, Cristina Cosco, Raffaella Marasco, Patrizia Doldo

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

IBD: CYTOKINES, RECEPTORS AND SIGNALING Participants will be able to: • Become familiar with cytokines and signaling. W1150

W E D N E S D A Y MAY 21

Phosphatidylcholine Delays TNF-α-Induced ProInflammatory Signalling and Interferes with the Compartementalization of TNF-α Receptors to Sphingolipid/ Cholesterol Enriched Microdomains (Lipid Rafts) At the Plasma Membrane Irina Treede, Petia Jeliaskova, Annika Braun, Thomas Giese, Joachim Fuellekrug, Wolfgang Stremmel, Gareth Griffiths, Robert Ehehalt*

W1151

A Mechanism of Action for Cyclosporine a in Ulcerative Colitis: The Role of the Tec Kinase Itk in Disease Pathogenesis Raja Narayana Atreya*, Benno Weigmann, Brigitte Bartsch, Peter R. Galle, Markus F. Neurath

W1153

Anti-TNF Agents Target Mucosal Intercellular Signaling in Inflammatory Bowel Diseases: A Common Molecular Mechanism of Action of Clinically Effective Anti-TNF Agents Raja Narayana Atreya*, Brigitte Bartsch, Peter R. Galle, Markus F. Neurath

W1154

Macrophage Mannose Receptor Deficient Mice Are More Susceptible to Helicobacter Hepaticus Induced Colitis. Sigrid Heinsbroek*, Kevin J. Maloy, Philip Ahern, Mark Asquith, Sofia M. Buonocore, Fiebo J. ten Kate, Wouter de Jonge, Guy E. Boeckxstaens, Siamon Gordon

W1155

IL-21 Receptor Signaling Enhances NK Cell Cytolytic Activity and Induces Proinflammatory Cytokine Production in Inflammatory Bowel Disease Zhanju Liu*, Jinxia Jiu, Huixia Zhang

W1156

W1157

W1158

IL-23 Is Highly Expressed in Inflammatory Bowel Disease and Induces T Cell Proinflammatory Cytokine Secretion Zhanju Liu*, Jinxia Jiu, Huixia Zhang Intestinal IL-7 Is Not Essential for the Persistence of IL7-Dependent Chronic Colitis Takayuki Tomita*, Takanori Kanai, Yasuhiro Nemoto, Toshimitsu Fujii, Teruji Totsuka, Mamoru Watanabe Azathioprine Modulates Human Monocyte Function Via the Pak-2 Signaling Pathway Lu Zhou*, Klaas Nico Faber, Maikel P. Peppelenbosch, Gerard Dijkstra

W1159

Interleukin-22: A Marker of Activity in Crohn's Disease Sabine Thieler*, Ulrike Strauch, Gerhard Rogler, Claudia Ott, Jürgen Schölmerich, Florian Obermeier

W1160

Adalimumab Prevents TNFα Induced Barrier Disruption in An In Vitro Model Andreas Fischer*, Markus Gluth, Ulrich-Frank Pape, Bertram Wiedenmann, Franz Theuring, Daniel C. Baumgart

W1174

Innate Anti-TNFα Antibodies That Neutralize TNFα Are Found in Patients Who Are Subsequent Nonresponders to Infliximab Ellen C. Ebert*, Kiron M. Das, Sima Mithani

W1161

The Anti-Inflammatory Actions of Glucagon-Like Peptide-2 (GLP-2) Are Not Dependent On IL-10 Signalling Laurie E. Wallace*, Catherine Ivory, Elaine de Heuvel, David Sigalet

W1175

Quantitative Measurement of Cytokine mRNA At Onset of Crohns Disease (CD) and Differential Patterns in Activity, Clinical Remission and Mucosa Healing Belen Beltran*, Pilar Nos, Marisa Iborra, Guillermo Bastida, Francisco Dasi, Ines Moret, Julio Ponce

P-296

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL W1176

Heme Oxygenase-1 Suppresses IL-12 Secretion with Inhibition of IFN-Stat Signaling: A Potential Therapeutic Target for TH1-Type Colitis Ikuo Nakamichi*, Takayuki Matsumoto, Takashi Kobayashi, Aida Habtezion, Akihiko Yoshimura, Bishr Omary, Mitsuo Iida

W1177

Expression, Localization and Systemic Concentration of Vascular Endothelial Grow Factor (VEGF) and Its Receptor in Patients with Ulcerative Colitis Antoni Stadnicki*, Dorota Frysz-Naglak, Ewa KlimackaNawrot, Celina Kruszniewska, Urszula Mazurek, Kajor Maciej

W1178



Unique Epigenetic Modification of IFNG in Inflammatory Bowel Disease Is Linked to Functional Expression in the Mucosa Rivkah Gonsky*, Richard L. Deem, Stephan R. Targan

W1179



TL1A (Tnfsf15) Enhances the Activation of TH17 Cells During Chronic Intestinal Inflammation Hidetoshi Takedatsu*, Kathrin S. Michelsen, Carol J. Landers, Lisa S. Thomas, Stephan R. Targan

W1180

Endogenous IGFBP-3 Activates TGF-β Receptors and Regulates Type I Collagen Expression and Production in Human Intestinal Smooth Muscle Cells in Crohn's Disease Robert S. Flynn*, Jennifer G. Bowers, John F. Kuemmerle



W1186

CARD15/NOD2 Mediates Susceptibility to Yersinia Pseudotuberculosis Ulrich Meinzer*, Sophie Esmiol-Welterlin, Frederick Barreau, Dominique Berrebi, Monique Dussaillant, Stephane Bonacorsi, Fabrice Chareyre, Michiko Niwa-Kawakita, Corinne Alberti, Ghislaine Sterkers, Thecla Lesuffleur, Michel Peuchmaur, Michael Karin, Lars Eckmann, Marco Giovannini, Vincent Ollendorff, Hans Wolf-Watz, JeanPierre Hugot

W1187

STAT3 Is Activated Throughout the Gastrointestinal Tract in Enterotoxigenic Bacteroides fragilis Induced Colitis Shervin Rabizadeh*, Shaoguang Wu, Emilia Albesiano, XinQun Wu, Laura Mirviss, Ki-Jong Rhee, Hong-Rong Yen, Drew M. Pardoll, Cynthia Sears

W1188

Dominant Genotypes in Mucosa-Associated Escherichia coli Strains from Pediatric Patients with Inflammatory Bowel Disease Valerio Iebba*, Maria Pia Conte, Serena Schippa, Marta Aleandri, Catia Longhi, John Osborn, Osvaldo Borrelli, Paola Falconieri, Salvatore Cucchiara

W1189

Crohn's Disease-Associated Escherichia coli Lf82 Aggravates Colitis in Injured Mouse Colon Via Signalling By Flagellin Frédéric Carvalho, Nicolas Barnich*, Pierre Sauvanet, Claude Darcha, Agathe Gelot, Arlette Darfeuille-Michaud

W1190

Expression of Functional TLR and NOD Proteins in Human Mesenteric Preadipocytes Thorsten Stroh*, Arvind Batra, Rainer Glauben, Inka Fedke, Britta Siegmund, Martin Zeitz

W1191

Effects of Ehec-Derived Autotransporter Serine Protease Espp On Human Endothelial Cells Sabrina Werth*, Jens Brockmeyer, Andreas Luegering, Helge Karch, Wolfram W. Domschke, Matthias Bruewer, Jan Heidemann

W1192

The Effect of α4 Integrin Blockade On the Development of Isolated Lymphoid Follicles Caihong Wang*, Keely McDonald, Conway C. Huang, Rodney D. Newberry

Helminth-Induced Alternatively Activated Macrophages in Bacterial Colitis: Impaired Autophagy As a Mechanism of Exacerbated Intestinal Inflammation in Citrobacter Infection Meiqian Weng, Lijian Wang, Shuo Li, W. Allan Walker, Bobby J. Cherayil, Hai Ning Shi*

W1193

Molecular Fingerprinting of the Gut Microbiota of Twins Reveals Differences According to Crohn's Disease Jonas Halfvarson*, Johan Dicksved, Magnus Rosenquist, Gunnar Järnerot, Curt Tysk, Lars Engstrand, Janet K. Jansson

Mucosal and Luminal Flora Are Distinct in Ulcerative Colitis (UC) Inflamed Pouches Compared to Healthy Familial Adenomatous Polyposis (FAP) Pouches Garrett C. Zella*, Elizabeth J. Hait, Tiffany Glavan, Christopher L. Kitts, Joshua R. Korzenik

W1194

Differential In Vitro Epithelial Translocation and Resistance to Phagocyte Uptake and Killing By Escherichia coli Strains Correlate with Their Ability to Induce Colitis in Monoassociated IL-10-/- Mice Bo Liu*, Jonathan J. Hansen, Lisa C. Holt, Sandra C. Kim, Belgin Dogan, Kenneth W. Simpson, R. Balfour Sartor

P-Glycoprotein Deficient Dendritic Cells Have Greater Activation Following Treatment with TLR4 and TLR9 Ligands Reed A. Dimmitt*, Anna Seay, Robin G. Lorenz

W1196

Bacterial Localization and Antigen-Specific Immune Response in Citrobacter rodentium Infection Hideyuki Shiomi*, Masaru Yoshida, Hiromu Kutsumi, Takeshi Azuma

Stability of Gut Microbiota Over Time in Crohn's Disease Patients Compared to Healthy Relatives Marie Joossens*, Vicky De Preter, Kristel Van Steen, Nathalie Vermeulen, Geert Huys, Kristin Verbeke, Peter Vandamme, Paul Rutgeerts, Séverine Vermeire

W1197

Oral Administration of Bifidobacterium Attenuates Inflammatory Responses of Spleen Cells to Escherichia coli in Neonatal Germ Free and Caesarian Delivered Mice Masako Yajima*, Masaki Terahara, Tsuyoshi Shibata, Makoto Yamaguchi, Shinya Nagafuchi, Junji Hoshiba, Kikuji Itoh, Takaji Yajima

W1198

Genetic and Biologic Characterization of Invasive E. coli in Crohn's Disease Maiko Sasaki*, Jan-Michael A. Klapproth

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

MICROBIAL- INDUCED MUCOSAL INFLAMMATION AND IMMUNITY Participants will be able to: • Recognize the various aspects of mucosal inflammation and immunity in microbial interactions. W1181

W1182

W1183

W1184

W1185

CpG Oligonucleotide Stimulation of TLR9 Inhibits Il17 Production from Mesenteric Lymph Node Cells Ahmed Metwali, Sarah Winckler, M.Nedim Ince, David E. Elliott*

Denotes DDW Poster of Distinction

P-297

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL W1200

W1201

W E D N E S D A Y MAY 21

An Oral Prophylactic Vaccine Comprised of Helicobacter bilis Antigens Encapsulated in a Self Assembled Tris Cationic Lipid Prevents IBD-Like Disease in IL-10 Deficient Mice Stephen J. Danon*, Minoo J. Moghaddam, Vanessa Stebbings Production of IL-10 By Colonic Dendritic Cells Is Associated with Higher Concentrations of Faecal Microbiota in Patients with Active Crohn's Disease Siew C. Ng*, Andreas Koutsoumpas, Charlotte R. Hedin, Neil E. McCarthy, Sophie Plamondon, Michael A. Kamm, Stella C. Knight, Alastair Forbes, James O. Lindsay, Kevin Whelan, Andrew J. Stagg

W1202

Helicobacter bilis Infection Alters the Spatial Distribution of Commensal Bacteria in Colitic C3h/Hen Mice Albert Jergens*, Todd A. Atherly, Robert T. Doyle, Abigail Henderson, Kelley M. Clausen, Cherie Ziemer, Michael J. Wannemuehler

W1203

Despite Mucosal CD4+ T Cell Depletion, the Prevalence of GI Symptoms Is Low During Acute and Early HIV-1 Infection Thomas C. Lee*, Saurabh Mehandru, Okebugwu Kamalu, Lisa Malter, Martin Markowitz, Michael A. Poles

W1204

Association of Serum Levels of Ficolin-2 and Ficolin-3 with Bacterial and Yeast Antigens and Distinct Crohn's Disease Phenotypes Alain Schoepfer*, Thomas Schaffer, Stefan Mueller, Beatrice Seibold-Schmid, Frank Seibold

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

MUCOSAL LYMPHOCYTE FUNCTION AND REGULATION II Participants will be able to: • Learn more about the various aspects of mucosal lymphocyte function and regulation. W1211

Invariant Natural Killer T Cell Deficiency Exaggerates Both Inflammation and Tumorigenesis On a Mouse Colitis-Associated Colon Cancer Model Kyoko Yoshioka*, Yoshitaka Ueno, Shinji Tanaka, Toshiko Onitake, Rie Hanaoka, Tsuyoshi Hatakeyama, Masaru Shimamoto, Masamoto Kanno, Hiromistu Watanabe, Kazuaki Chayama

W1212

The Role of CD8+ T Cells in Oral Tolerance Paul M. Arnaboldi*, Lloyd Mayer

W1213

Lymphoneogenesis: A New Component in Inflammatory Bowel Disease Pathogenesis Carmen Correale*, Stefania Vetrano, Francesca Tognoli, Tommaso Stefanelli, Claudia Ligorio, Paolo Omodei, Alessandro Repici, Alberto Malesci, Elisabetta Dejana, Silvio Danese

W1214

The Chemokine Cxcl12 Has Constitutive and Inflammation-Induced Expression By Intestinal Epithelial Cells In Vivo, and Attracts Cxcr4+ InterferonGamma (IFN-Gamma) Secreting Mucosal Lymphocytes In Vitro Iris Dotan*, Lael Werner, Uri Kopylov, Hagit Tulchinsky, Eli Brazowski, Hofit Elad, Hanan Guzner-Gur, Zamir Halpern

W1215

MDP Stimulates Memory T-Cell Recruitment Via NOD2 Connecting Bacterial Sensing and Adaptive Immunity Isabelle Frey*, Achim Weber, Christoph Zeitler, Katrin Menzel, Michael Fried, Gerhard Rogler, Martin Hausmann

W1216

Positive Regulation of T Cell Activation By Lipid Raft Protein Swiprosin-1 Suck Chei Choi, Tae Hyeon Kim, Yong Sung Kim, Chang Soo Choi, Ki Hoon Kim, Ki Jung Yun, Hyun Mee Oh, Chang Duk Jun*

W1205

Eosinophils in Chronic Gastritis: Possible Implications in Carcinogenesis M. Blanca Piazuelo*, M. Constanza Camargo, Robertino M. Mera, Alberto Delgado, Richard M. Peek, Hernan Correa, Barbara G. Schneider, Liviu A. Sicinschi, Yolanda Mora, Luis E. Bravo, Pelayo Correa

W1206

Impaired Sulphide Detoxification in Ulcerative Colitis Is Related to Inflammation Vicky De Preter*, Ingrid Arijs, Els Houben, Paul J. Rutgeerts, Kristin Verbeke

W1207

Novel “Burkholderia-Like” 23s Ribosomal DNA Detected in Ileal Biopsies of Paediatric Crohn's Disease Huiyan W. Sim*, Karen Boniface, Josef Wagner, Don Cameron, Anthony G. Catto-Smith, Ruth F. Bishop, Carl D. Kirkwood

W1208

Variable Detection of Entero-Hepatic Helicobacter Species in Colonic Mucosal Pinch Biopsies By Different Molecular Techniques John M. Thomson*, Georgina Hold, Susan H. Berry, Noha E. El-Sakka, Norman A. Mowat, Zeli Shen, Nancy S. Taylor, James G. Fox, Emad El-Omar

AGA Institute Poster Session 8:00 AM - 5:00 PM

FC Gamma Receptors On Antigen Presenting Cells Can Regulate the Mucosal Defense Against Enteric Bacteria Atsuhiro Masuda*, Masaru Yoshida, Tsukasa Ishida, Ryo Chinzei, Hiroshi Tanaka, Hideyuki Shiomi, Shigeto Mizuno, Richard S. Blumberg, Takeshi Azuma

UNCONTROLLED THERAPEUTIC OBSERVATIONS IN HUMANS

W1210



W1210a Neonatal Exposure to Bacterial Antigens Reduces Intestinal Inflammation in IL-10 Gene-Deficient Mice Beate C. Sydora*, Sarah M. MacFarlane, Richard Fedorak



W1210b An Imbalance in Cytokine Production Mediates Transient Intestinal Inflammation in Germfree Mice Following Bacterial Colonization Beate C. Sydora*, Sarah M. MacFarlane, Maryla E. Lupicki, Levinus A. Dieleman, Richard Fedorak



P-298

Sails Pavilion San Diego Convention Center

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Disease

Participants will be able to: • Evaluate recent clinical research on uncontrolled therapeutic observations in humans. W1217

Breastfeeding During Maintenance Azathioprine Treatment (AZA) in Patients with Crohn's Disease (CD) Sieglinde Angelberger*, Walter Reinisch, Agnes Messerschmidt, Wolfgang Miehsler, Gottfried Novacek, Harald Vogelsang, Clemens Dejaco

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL W1218

W1219

W1220

W1221

Experience of Maintenance Infliximab Therapy for Refractory Ulcerative Colitis in England Evangelos Russo*, Adam Harris, Simon Campbell, James O. Lindsay, Ailsa L. Hart, Naila Arebi, Andrew Milestone, H. H. Tsai, Julian Walters, David Westaby, Andrew Thillainayagam, Marta Carpani, Devinder Bansi, Subrata Ghosh

W1229

5-ASA Therapy and a Lower Inflammatory Score in Chronic Ulcerative Colitis Are Associated with a Decreased Risk of Dysplasia and Colorectal Cancer Sam Nourani*, Dezheng Huo, Williamson Strum, David T. Rubin

W1230

Retrospective Evaluation of the Safety and Effect of Adalimumab Therapy (Reseat) in Pediatric Crohn's Disease Joel R. Rosh*, Trudy Lerer, James Markowitz, Sridhar R. Goli, Petar Mamula, Joshua D. Noe, Marian D. Pfefferkorn, Kathleen T. Kelleher, Anne M. Griffiths, Subra Kugathasan, David Keljo, Maria Oliva-Hemker, Wallace Crandall, Ryan S. Carvalho, David R. Mack, Jeffrey S. Hyams

CD4+Cd25highfoxp3+ T-Regulatory Cells in Crohn's Disease Patients Treated with Infliximab Antonio Di Sabatino*, Manuela Rosado, Paolo Biancheri, Paolo Cazzola, Laura Rovedatti, Rita Carsetti, Thomas T. MacDonald, Gino R. Corazza

W1231

Flexibility in Interval and Dosing of Infliximab Enables Maintained Response of Patients with Crohn's Disease Fabian Schnitzler*, Herma Fidder, Marc Ferrante, Maja Noman, Gert A. Van Assche, Ilse Hoffman, Severine Vermeire, Paul J. Rutgeerts

Interferon-Beta for Ulcerative Colitis: Clinical Remission Is Associated with Interleukin-13 Inhibition Peter Mannon*, Ivan J. Fuss, Catherine Groden, Zhiqiong Yang, Harold Dickensheets, Chuli Yi, Julia Friend, Ronald L. Hornung, Raymond Donnelly, Michael D. Yao, Warren Strober

W1232

Bridging Therapy with Cyclosporine and 6mp Significantly Reduces Long-Term Colectomy Rates in Patients with Severe Ulcerative Colitis Adam S. Cheifetz, Joshua E. Stern, Sagar Garud*, Lisa Malter, Eric S. Goldstein, Alan C. Moss, Daniel H. Present

W1233

A Lecithinized Superoxide Dismutase (PC-SOD) Improves Ulcerative Colitis Susumu Okamoto*, Nagamu Inoue, Tadakazu Hisamatsu, Haruhiko Ogata, Yasuo Suzuki, Takayuki Matsumoto, Toshifumi Hibi

Long-Term Efficacy and Safety of Adalimumab Treatment in a Single-Center Cohort of Crohn's Disease Patients Who Failed to Infliximab Treatment Konstantinos Karmiris*, Maja Noman, Fabian Schnitzler, Herma Fidder, Ioannis E. Koutroubakis, Elias Kouroumalis, Severine Vermeire, Gert A. Van Assche, Paul Rutgeerts

W1222

Cyclosporine a Treatment of Severe Steroid-Refractory Ulcerative Colitis During Pregnancy Julien Branche*, Antoine Cortot, Arnaud Bourreille, Benoit Coffin, Martine De Vos, Philippe Seksik, Philippe R. Marteau, Marc Lemann, Jean-Frédéric Colombel

W1223

Long-Term Outcome of Treatment with Tacrolimus Therapy in Patients with Ulcerative Colitis Shuji Yamamoto*, Hiroshi Nakase, Satoko Inoue, Sakae Mikami, Norimitsu Uza, Satoru Ueno, Tsutomu Chiba

W1224

W1225

In Patients with Ulcerative Colitis, Adsorptive Depletion of Peripheral Myelocytic Leukocytes Impacts Mucosal Levels of Inflammatory Cells and Clinically Is Most Effective in Steroid Naïve Patients: Colonoscopic and Histologic Investigations Tomotaka Tanaka*, Hideharu Okanobu, Abbi Saniabadi, Toshihide Oya Budesonide Is An Effective But Underutilized Therapy in Pediatric Crohn Disease Anthony R. Otley*, James Markowitz, Neal S. LeLeiko, Anne M. Griffiths, Wallace Crandall, Subra Kugathasan, Maria Oliva-Hemker, Athos Bousvaros, Marian D. Pfefferkorn, David R. Mack, Jonathan Evans, Joel R. Rosh, David Keljo, Petar Mamula, M. Susan Moyer, Ryan S. Carvalho, Benny Kerzner, Marsha H. Kay, Trudy Lerer, Jeffrey S. Hyams

W1226

Trough Serum Infliximab Predicts Outcome for Ulcerative Colitis Treatment with Infliximab Cynthia H. Seow*, Mark S. Silverberg, Alvin Newman, A. Hillary Steinhart, Gordon R. Greenberg

W1227

Analysis of the Safety Profile of Anti-TNF Therapy in Over 200 Patients with Inflammatory Bowel Disease in Edinburgh Identifies a Potential Causal Link with Lung Cancer in Smokers Charles W. Lees*, Gwo-Tzer Ho, Aneesa I. Ali, Alex I. Thompson, Alan G. Shand, Ian D. Penman, Kelvin R. Palmer, Peter M. Gillett, David C. Wilson, Ian D. Arnott, Jack Satsangi

W1228

Prospective Scheduled Magnetic Resonance Imaging (MRI) to Guide Perineal Crohn's Fistula Treatment with Infliximab, Adalimumab and Thalidomide Siew C. Ng*, Sophie Plamondon, Anna Swatton, Arun Gupta, Michael A. Kamm

W1234

A Prospective Follow-Up Study to Assess the Long-Term Efficacy of Leukocytapheresis in Patients with Steroid Refractory Ulcerative Colitis Ken Fukunaga*, Kunio Ohnishi, Nobuyuki Hida, Yoshio Ohda, Katsuyuki Tozawa, Koji Kamikozuru, Kazuko Nagase, Shiro Nakamura, Hiroto Miwa, Takayuki Matsumoto

W1235

Efficacy of Methotrexate in Crohns Disease Patients Previously On Thiopurine Therapy Mahmood Wahed*, John R. Louis-Auguste, Louisa M. Baxter, Jimmy K. Limdi, James O. Lindsay, Sara McCartney, Stuart L. Bloom

W1236

Safety of Chronic 5-ASA Use in the Elderly Inflammatory Bowel Disease Population Camille Sommer*, Richard Feldstein, Shanti Raju, Lou R. Mastrine, Seymour Katz

W1237

Long-Term Safety of Prochymal Adult Mesenchymal Stem Cells in Crohn's Disease Jane Onken*, Tracy Jaffe, Linda Custer

W1238

The Remitrac Infusion Registry: Safety and Management of Infliximab Infusions in a Real-Life Setting Rafat Faraawi, Majed Khraishi, Denis Choquette, William Bensen, Francois Nantel*

W1239

Efficacy of Methotrexate in Ulcerative Colitis Mahmood Wahed*, John R. Louis-Auguste, Louisa M. Baxter, Jimmy K. Limdi, Sara McCartney, Stuart L. Bloom, James O. Lindsay

W1240

Adalimumab for Crohn's Disease in Clinical Practice At An Academic Medical Center: The First 118 Patients Jason M. Swoger*, Edward V. Loftus, Darrell S. Pardi, Sunanda V. Kane, William J. Tremaine, Yuning Xiong, Karen A. Hanson, William S. Harmsen, Alan R. Zinsmeister, William J. Sandborn

W1241

Does Immunogenicity Play a Role in Adalimumab Treatment for Crohn's Disease? Rachel L. West*, Zuzana Zelinkova, Gertjan Wolbink, E. J. Kuipers, Pieter C. Stokkers, Christien J. van der Woude

Denotes DDW Poster of Distinction

P-299

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL

W E D N E S D A Y

W1242

Patient Preferences for Subcutaneous Versus Intravenous Formulations of Anti-TNF Agents for Treatment of Inflammatory Bowel Disease Suresh Pitchumoni, Ellen J. Scherl, Brian P. Bosworth*, Thomas C. Lee, Michael A. Poles

W1243

Concomitant Use of Immunosuppressive Therapy in An Outpatient IBD Subspecialty Clinic Results in Rates of Response Higher Than Those Seen in the Infliximab Randomized Controlled Trials Christopher W. Teshima*, Adrienne F. Thompson, LeRose S. Dhanoa, Richard Fedorak

W1244

Efficacy of a Third Anti-TNF Monoclonal Antibody in Crohn's Disease After Failure of Two Other Anti-TNF Nicolas Mozziconacci, Severine Vermeire, David Laharie, Edouard Louis, Marc-André Bigard, Xavier Hebuterne, Yoram Bouhnik, Gert A. Van Assche, Marc Lemann, Paul J. Rutgeerts, Jean-Frédéric Colombel, Matthieu Allez*

W1245

MAY 21 W1246

W1247

W1248

W1249

W1253

Low Dose Thalidomide in Immunosupressive Unresponsive IBD; Effectiviness and Side Effects Ibrahim Hatemi*, Gulen Hatemi, Ebubekir Senates, Birol Baysal, Yusuf Erzin, Aykut F. Celik

W1254

The Decreased TLR2 Expression and Elevated IL-8 Production On Peripheral Leukocytes in Patients with Active Ulcerative Colitis: The Modulation of the Leukocyte Sensitivity to Pgn By Granulocyte and Monocyte Apheresis Yasuo Suzuki*, Akihiro Yamada, Hiroshi Aoki, Aisaku Osamura, Kentaro Nakamura, Yasushi Yoshimatsu, Nobuo Hosoe, Nobuo Takada, Yukio Tsuda, Koji Shirai

W1255

Durability of Infliximab in Crohn's Disease Patients Treated with Maintenance Infusions Beyond One Year Jason E. Gonzaga*, Mazen Issa, Susan Skaros, Joshua F. Knox, Jeanne Emmons, Dawn B. Beaulieu, Kathryn Lemke, Ashwin N. Ananthakrishnan, David G. Binion

W1256

History of Interrupted Infliximab Dosing Significantly Diminishes Efficacy During Long-Term Maintenance Therapy in Crohn's Disease Daniel Stein*, Mazen Issa, Susan Skaros, Joshua F. Knox, Kathryn Lemke, Jeanne Emmons, Mary F. Otterson, Ashwin N. Ananthakrishnan, David G. Binion

W1257

Are We Able to Predict Antimicrobial Response in Patients Who Have Undergone Ileocecal Resection and Have Documented Small Bowel Bacterial Overgrowth Via Hydrogen Breath Testing?: Evaluation of Antibiotic Response and Characteristics of the Hydrogen Breath Test Jesse Liu*, David C. Metz, Joshua E. Stern, Andrew D. Rhim, Faten Aberra, James D. Lewis, Gary R. Lichtenstein

The Arg381gln SNP in IL 23 R Does Not Influence Response to Immunomodulators in Ulcerative Colitis or Crohn's Disease Bijay Baburajan*, Natalie Prescott, Mark Tremelling, Fraser Cummings, Miles Parkes, Derek P. Jewell, Christopher G. Mathew, Anthony M. Marinaki, Jeremy D. Sanderson

W1258

Short-Term Efficacy and Safety of Adalimumab in Children with Active Crohn's Disease: A Prospective, Open Label, Single Center Trial Franca Viola, Fortunata Civitelli, Erminia Romeo, Giulia Maiella, Federica Nuti, Marina Aloi, Osvaldo Borrelli, Salvatore Cucchiara*

The Combined Effect of the Aicartase C347g and the Aldehyde Oxidase A3505g SNPs Predict Efficacy of Methotrexate Therapy in Inflammatory Bowel Disease Bijay Baburajan*, Natalie Prescott, Monica ArenasHernandez, Mark Tremelling, Fraser Cummings, Miles Parkes, Derek P. Jewell, Azhar Ansari, Christopher G. Mathew, Anthony M. Marinaki, Jeremy D. Sanderson

W1259

A 14 bp Ins/Del Polymorphism in HLA-G Influences Response to Azathioprine in Crohn's Disease But Not in Ulcerative Colitis Bijay Baburajan*, Natalie Prescott, Melissa Smith, Azhar Ansari, Christopher G. Mathew, Anthony M. Marinaki, Jeremy D. Sanderson

W1260

Is There An Association Between Common Variable Immunodeficiency and Microscopic Colitis? Reena Chokshi*, Monina F. Pascua, Ashlie Burkart, Faten Aberra, Arnold I. Levinson, David C. Metz

W1261

Use of Atorvastatin As An Anti-Inflammatory Treatment for Crohn's Disease Olof Grip*, Sabina Janciauskiene, Anders Bredberg

W1262

Prospective, Open Pilot Study for Evaluating the Clinical Efficacy and Mucosal Healing Rate of Infliximab in Steroid-Dependent Ulcerative Colitis Manuel Barreiro*, Aurelio Lorenzo, José Mera, Enrique Dominguez-Munoz

W1263

Increased Plasma Ghrelin Following Infliximab in Crohn's Disease Edmond Z. Sung*, Nancy F. da Silva, Steve J. Goodyear, Lam Chin Tan, Philip G. McTernan, Sudhesh Kumar, Chuka U. Nwokolo

W1264

Does Psychological Counselling Alter the Natural History of Inflammatory Bowel Disease? Mahmood Wahed*, Meg Corser, David S. Rampton

Successful Induction of Clinical Response and Remission with Certolizumab Pegol in Crohn's Disease Patients Who Are Primary Non-Responders or Intolerant to Infliximab: A Real Life Multi-Center Experience of Compassionate Use Silvio Danese*, Filippo Mocciaro, Luisa Guidi, Maria Lia Scribano, Michele Comberlato, Marcello Vangeli, Raffaella Pulitanò, Aldo Manca, Alessandro Armuzzi, Alberto Malesci, Cosimo Prantera, Mario Cottone

Microarray Analyses of UC Biopsies Suggests 5asa Reduces PI3 Kinase Signaling and Beta Catenin Activation Elizabeth Managlia*, Ishfaq Bhat, Badar Muneer, Terrence A. Barrett Intensification of Infliximab (Ifx) Therapy in Crohn's Disease: Efficacy and Safety Maria Chaparro, P. Martínez-Montiel, Manuel Van Domselaar, Fernando Bermejo, Jl Perez-Calle, B. Casis, Antonio López-San Román, Alicia Algaba, José MatéJiménez, Javier P. Gisbert*

W1250

Early Experience with Adalimumab for the Treatment of IBD in An Academic Medical Center Arun C. Swaminath*, Melissa H. Rosen, Lloyd Mayer, Thomas A. Ullman, Simon Lichtiger, Maria T. Abreu

W1251

Association of Lactobacillus Acidophilus and Lactobacillus Salivarius Improves Seronegative Spondyloarthropathy in Patients with Inactive Ulcerative Colitis: Preliminary Data Marco Sanges*, Matilde Rea, Giovanna Valente, Flora Caruso, Rosa Della Gatta, Luciano Lozio, Agesilao D'Arienzo

W1252

Ciclosporin Use in Acute Ulcerative Colitis: The Oxford Regional Dgh Experience Nishchay Chandra*, Neil Rajoriya, David Gorard, Alistair McIntyre, Jon Simmons, Antony Ellis

P-300

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL W1265

Infliximab in Combination with Immunomodulators in the Treatment of Children with Crohn's Disease: Advantages and Risks Gigi Veereman*, Agnieszka Prytula, Tania Mahler, Philippe Alliet, Isabelle Paquot

W1266

Vitamin D Deficiency in Active Crohn's Disease Søren Peter G. Jørgensen*, Christian L. Hvas, Jørgen Agnholt, Lisbet A. Christensen, Lene Heickendorff, Jens F. Dahlerup

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

W1276

The Effect of Acid, Pepsin and Gastric Juice On the In Vitro Growth and Sporulation of Clostridium difficile Ala' Sharara*, Ihab I. ElHajj, Karim Maasri, Jana G. Hashash, George F. Araj

W1277

Recurrences of Clostridium difficile Associated DiarrheaSAME Strain or Different Strain? Jeffrey Cloud*, Laura Noddin, Amanda Pressman, Mary Hu, Ciaran P. Kelly

W1278

Clostridium difficile NaP-1 Strain Is Not Associated with Severe Disease in a Non-Epidemic Setting Jeffrey Cloud*, Amanda Pressman, Laura Noddin, Mary Hu, Ciaran P. Kelly

W1279

Race and Ethnicity As Risk Factors for Post-Surgical C. difficile Infection and Its Mortality Rabin Rahmani*, William Southern, Igal Khorshidi, Christopher B. Ibrahim, Andy J. Thanjan, Lawrence J. Brandt

W1280

Orthograde Intestinal Lavage Reduces Pain Intensity in Acute Uncomplicated Diverticulitis Karl J. Goerg*, Jutta Rauen-Vossloh, Jutta Rauen-Vossloh

W1281

Fecal Transplantation Via Colonoscopy for C. difficileAssociated Diarrhea; a Case Series of 6 Patients Sonia Yoon*, Lawrence J. Brandt

W1282

Transplantation and Proton Pump Inhibitors: Risk Factors for C. difficile Associated Disease in Hospitalized Patients Thomas O. Kovacs*, Robyn L. Altman

W1283

Antibiotics and Cdt Expression in Campylobacter Jejuni Contribute to Duration of Colonization in Rats Sam-Ryong Jee*, Walter Morales, Kimberly Low, Christopher Chang, Reza Khoshini, Jeffrey L. Conklin, Mark Pimentel

W1284



Altered Blood B Cell Responses to Bacterial Stimulation in Patients with Irritable Bowel Syndrome (IBS) Lena Ohman*, Ann-Charlotte Lindmark, Stefan Isaksson, Iris Posserud, Hans Strid, Henrik Sjövall, Magnus Simren

W1285

Treatment of Post-Infectious Irritable Bowel Syndrome and Non Infective Irritable Bowel Syndrome with mesalazine Mauro Bafutto*, Jose R. Almeida, Roberta C. Almeida, Thaís C. Almeida, Naylé V. Leite, Joffre Rezende Filho

Sponsored by: Intestinal Disorders

CLINICAL INTESTINAL DISORDERS III Participants will be able to: • Familiarize themselves with recent clinical intestinal disorders research findings and implications. W1267



Feeding Lactose Compared to a Polycose-Based Formula Improves Hexose Absorption and Reduces NEC in Preterm Pigs Thomas Thymann, Randal K. Buddington, Stine B. Bering, Douglas Burrin, Hanne K. Moeller, Per T. Sangild*

W1268



Mechanism of Astrovirus Induced Diarrhea Prashant K. Nighot*, Matthew D. Koci, Adam J. Moeser, Rizwana Ali, Anthony T. Blikslager

W1269

HIV Protease Inhibitors Induce ER Stress and Disrupt Barrier Function in Intestinal Epithelial Cells Xudong Wu*, Emily C. Gurley, Elaine Studer, Li Chen, Xuan Wang, Jie Chen, Jian-Ying Wang, Phillip Hylemon, William M. Pandak, Arun J. Sanyal, Luyong Zhang, Huiping Zhou

W1270

Patients with Fructose Malabsorption Do Have Reduced Tryptophan Plasma Levels and Alterations in Platelet SERT Function Marco Schmidtmann*, Julius Büchner, Ivo R. van der Voort, Andrea Riedl, Peter Kobelt, Hubert Mönnikes

W1271

W1272

Dramatic Decrease of Breath Hydrogen Excretion and Gastrointestinal Symptoms After Ingestion of Tilactase Enzymes (β-D-Galactosidase) in Subjects with Hypolactasia Rosa C. Sasso*, Ersilia Romanelli, Francesca Bello, Samantha Altini, Lucia Gelao, Marcin Krawczyk, Giuseppe Palasciano, David Q. Wang, Piero Portincasa Nitazoxanide in the Treatment of Clostridium difficile Disease Daniel M. Musher*, Nancy D. Logan, Adam M. Bressler, David P. Johnson, Jean-François Rossignol

W1273

Lack of Correlation Between Gastrointestinal Symptoms and Helicobacter pylori Infection in Children Maria Pina Dore*, Paolo A. Tomasi, Giuseppe Fanciulli, Giuseppe Realdi, Giuseppe Delitala, Hoda M. Malaty

W1274

Macropinocytosis Is Involved in Shiga Toxin 1 Uptake and Transcytosis By Gb3-Negative Human Intestinal Epithelial Cells Irina Malyukova, Anne Kane, Mark Donowitz, Olga Kovbasnjuk*

W1275

Failure of Metronidazole Therapy for C. difficileAssociated Disease (Cdad): Risk Factors and Historical Trends Mary Hu*, Seema Maroo, Jeffrey Cloud, Sanjeev Tummala, Kianoosh Katchar, Valley Dreisbach, Laura Noddin, Ciaran P. Kelly

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Intestinal Disorders

NOVEL DIAGNOSTICS AND THERAPEUTICS IN INTESTINAL DISEASE Participants will be able to: • Evaluate novel diagnostics research and therapies in intestinal disease. W1286



Usefulness of Quantiferon-Tb Gold Test in the Differential Diagnosis of Intestinal Tuberculosis Ok-Jae Lee*, Jae-Min Lee, Hyun-Jin Kim

W1287



A Novel Magnetic Device to Prevent Fecal Incontinence Mauro Bortolotti*, Giampaolo Ugolini, Annamaria Grandis, Isacco Montroni, Giosuè Mazzero

W1288

Anti-Epidermal Transglutaminase (Tge) IgA in Dermatitis Herpetiformis and Pediatric Celiac Disease Troy D. Jaskowski*, Tracy Hamblin, Harry R. Hill, John J. Zone, Linda Book, Christopher M. Hull

Denotes DDW Poster of Distinction

P-301

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL W1289

Partial Mesenteric Ischemia Alters Biomagnetic Slow Wave Adam Goodale, Chike B. Obioha, Jon Erickson, Andrei Irimia, Brandon Williams, Leonard A. Bradshaw*, William O. Richards

W1290

A New Concept in Targeting the Colon: A Combined pH and Bacterial Triggered Drug Delivery Technology for Improving the Treatment of Inflammatory Bowel Diseases Valentine Ibekwe, Hala Fadda*, Evans David, Abdul Basit

W1291

W E D N E S D A Y MAY 21

W1292

W1293

W1294

W1303

Spectral Analysis of Contractile Frequency in the Ileum and Proximal Colon: Characterization of Motility Patterns Using An Ambulatory Capsule, Smartpill Lenuta Kloetzer*, Alexandru Gaman, Vitaly Napadow, Richard McCallum, Kenneth L. Koch, Michael D. Sitrin, William D. Chey, Jeffrey M. Lackner, Leonard A. Katz, Gregory E. Wilding, Henry P. Parkman, Irene Sarosiek, André Smout, William L. Hasler, Jack Semler, Braden Kuo

W1304

Plasma Citrulline Acts As a Biological Marker of Intestinal Adaptation in a Monkey Model of Short Bowel Syndrome Lidia L. Demchyshyn*, Kerri L. Trendler, Clynn Wilker

Are Patients with Chronic Iron-Deficiency Anaemia Different from Those with Occult Gastrointestinal Bleeding? Clinical Characteristics and Diagnostic Yield of Capsule Endoscopy Michel Delvaux*, Muriel Frederic, Isaac Fassler, Gerard Gay

W1305

A Novel Non Invasive Genetic Test to Diagnose Hypolactasia in Adult Patients Maria Pina Dore*, Antonietta Pedroni, Leena Peltonen, Nabil S. Enattah, Vincenza Tadeu, Giuseppe Delitala, Luca Cavalli Sforza, Domenica Obinu

Utility and Characteristics of Duodenal Aspirate to Detect Small Intestinal Bacterial Overgrowth (SIBO) Anar Mashruwala*, Chadwick W. Hatfield, Steve P. Harrell, Forest Arnold, Jennifer Eversmann, James W. Snyder, John M. Wo

W1306

Eosinophilia Is Overlooked in Routine Duodenal Biopsy Practice and Is Linked to a History of Atopy or Medication Marjorie M. Walker*, Claire E. Murray, Mussarat N. Rahim, Jonathan M. Hoare, Rupert Negus, Nicholas J. Talley

The Involvement of Cytomegalovirus in Patients with Intestinal BehçET's Disease Takuya Yoshino*, Hiroshi Nakase, Shuuji Yamamoto, Yasuhiro Takeda, Katsuhiro Kasahara, Satoru Ueno, Norimitsu Uza, Sakae Mikami, Tsutomu Chiba

W1307

The Role of Argon Plasma Coagulation (APC) in the Treatment of Chronic Radiation Proctitis Pierre Nel*, Andrea Faris, Richmond G. Sy

W1308

Small Bowel Disorders in Patients with Chronic Variable Immunodeficiency (CVID) - Capsule Endoscopy Findings Marc Karliova*, Salama Abdulgabar, Verena K. Haas, Herbert Lochs, Winfried A. Voderholzer

W1309

CT Angiography and 24 Hours Tonometry: A Novel and Usefull Approach in the Diagnosis of Chronic Gastrointestinal Ischemia Désirée van Noord*, Peter B. Mensink, P. M. Pattynama, M. R. van Sambeek, E. J. Kuipers

The Role of Faecal Lactoferrin in the Evaluation of Hospitalised Patients with Diarrhoea Daniel R. Van Langenberg*, Richard B. Gearry, Peter R. Gibson

W1295

Defining the Soluble Proteome of Human Stool Patrick S. Quint*, Jonathan J. Harrington, H. R. Bergen, David A. Ahlquist

W1296

Correlation of Biomagnetic and Bioelectric Recordings in a Patient with Ischemic Bowel Chike B. Obioha*, Adam Goodale, Jon Erickson, Leonard A. Bradshaw, William O. Richards

W1297

The Utility of Polymerase Chain Reaction in the Diagnosis of Colonic Tuberculosis Among Patients with Typical and Atypical Endoscopic Presentations Raquel R. Adaza

W1298

Antitumor Effect of a Statistic Magnetic Field-Assisted, Immunodelivery System Using Magnetized T Lymphocytes and Cytokines Takeshi Ohdaira

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility

CONSTIPATION, IBS AND OTHER COLONIC FUNCTIONAL AND MOTILITY DISORDERS

W1299

Prevention of GI Absorption of Bacterial Toxins: An In Vitro Evaluation of the Potential for Prophylactic Use of a Novel Oral Adsorbent (AST-120) Keith Anderson*, Laurent Fischer

W1300

AST-120: A Novel, Engineered Carbon Microsphere Product for Use in Chronic Inflammatory Bowel Disease and Liver Dysfunction Keith Anderson*, Shigemi Tomiyama, Toyohiko Nitta

W1310



Relationship Between Colonic Motor Functions and Transit in Constipation. Karthik Ravi, Adil E. Bharucha*, Michael Camilleri, Deborah L. Rhoten, Alan R. Zinsmeister

W1301

Sensitivity and Specificity of a Rapid Fecal Calprotectin Test in Patients with Chronic Non Bloody Diarrhea Gerassimos J. Mantzaris*, Anastassios Roussos, Angeliki Christidou, Stavroula Koilakou, Konstantinos Papamichail

W1311

W1302

Hydrogen Breath Test for Bacterial Overgrowth and IBS Linda Gillberg*, Christina Prior, Ulrika Mjörnell, Lars Blomquist, Per M. Hellström

The Anorectal and Colonic Functional Characteristics and the Effect of Biofeedback in Constipation with Spinal Cord Diseases Dong-Hoon Yang*, Seung-Jae Myung, Kee Wook Jung, Benjamin Kim, Do Hoon Kim, Soon Man Yoon, Mi Young Do, In ja Yoon, Byong Duk Ye, Jeong-Sik Byeon, HwoonYong Jung, Suk-Kyun Yang, Jin-Ho Kim

P-302

Participants will be able to: • Review recent research in constipation, IBS and other colonic functional and motility disorders.

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL W1312

W1313



Heightened Motor Activity Measured By a Wireless Capsule in Unprepared Colons of Patients with Complaints of Constipation: Relation to Colon Transit and IBS William L. Hasler*, Richard J. Saad, Satish S. Rao, Leonard A. Katz, Henry P. Parkman, Kenneth L. Koch, Richard McCallum, Braden Kuo, Irene Sarosiek, Michael D. Sitrin, Jeffrey M. Lackner, Gregory E. Wilding, Carrie Miller, Jack Semler, William D. Chey Wireless Capsule Quantification of Region-Specific Gastrocolonic Response and Sleep Inhibition of Colon Motor Activity in Unprepared Colons of Humans with Normal Colon Transit William L. Hasler*, Satish S. Rao, Kenneth L. Koch, Irene Sarosiek, Richard McCallum, Jeffrey M. Lackner, Henry P. Parkman, William D. Chey, Richard J. Saad, Braden Kuo, Carrie Miller, Michael D. Sitrin, Leonard A. Katz, Gregory E. Wilding, John r. Semler

W1314

Antegrade Enemas for Defecation Disorders: Does It Improve the Colonic Motility? Ann Aspirot*, Sergio Fernandez, Carlo Di Lorenzo, Beth Skaggs, Hayat Mousa

W1315

Evaluation of the Bristol Stool Form Scale As a Marker for GI Transit in Patients with Chronic Constipation Sajneet Khangura*, Zeeshan Ramzan, Alan H. Maurer, John Gaughan, Robert S. Fisher, Henry P. Parkman

W1316

Non-Invasive Evaluation of Colonic Motility By Electrocolonography (Ecog) Masako Kaji*, Toshiya Okahisa, Tetsuo Kimura, Tatsuzo Itagaki, Hisashi Takeuchi, Naoki Muguruma, Seisuke Okamura, Tetsuji Takayama, Akitsugu Murakami

W1317

The Effect of the Express Procedure On Rectal Biomechanics Chetan Bhan*, Julia Dench, Mark Scott, Peter J. Lunniss, Norman S. Williams

W1318

Automated Detection and Analysis of Human Rectal Motor Complex Activity Based On Consensus Expert Opinion Natalia Zarate*, Philip G. Dinning, André Smout, Satish S. Rao, Mark Scott

W1319

Long-Term Ambulatory Jejunal Manometry for Evaluation of Chronic Constipation Holger Seidl*, Felix Gundling, Christian Pehl, Wolfgang Schepp, Thomas Schmidt

W1320

The Effect of Neurotensin (NT) On Motility in Isolated, Vascularly Perfused Rat Colon Sei jin Youn*, Won Joong Jeon, Il young You, Hee bock Chae, Seon Mee Park

W1321

Famine in Early Life Is Associated with An Increased Risk of Developing Irritable Bowel Syndrome, a Population Based Cohort Study Tamira K. Klooker*, Breg Braak, Rebecca C. Painter, Susanne R. R. de Rooij, Ruurd M. van Elburg, Rene M. van den Wijngaard, Tessa J. Roseboom, Guy E. Boeckxstaens

W1322

W1323

Do Patients with Chronic Intractable Constipation and Rectal Hyposensitivity Also Have Evidence of Rectal Motor Dysfunction? Natalia Zarate*, Subash P. Vasudevan, Peter J. Lunniss, Mark Scott Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: Association with Colon Motility, Bowel Symptoms, and Psychological Distress Madhusudan Grover*, Motoyori Kanazawa, Denesh K. Chitkara, Lisa M. Gangarosa, Olafur S. Palsson, Douglas A. Drossman, Marsha J. Turner, William E. Whitehead

W1324

The Development of IBS, Abdominal Pain and Constipation Following Elective Hysterectomy Ami D. Sperber*, Carolyn B. Morris, Lev Greemberg, Shrikant I. Bangdiwala, David Goldstein, Eyal Sheiner, Yefim Rusabrov, Yuming J. Hu, Miriam Katz, Douglas A. Drossman

W1325

Postprandial Rectosigmoid Tone Modification: A New Diagnostic Test for Irritable Bowel Syndrome? Michele Di Stefano*, Paola Tana, Samanta Mazzocchi, Gino Roberto Corazza

W1326

Prevalence of Breath Methane Excretion Is Not Correlated to Clinical Presentation in IBS. the Role of Different Patterns of Breath Methane Excretion Michele Di Stefano*, Paola Tana, Samanta Mazzocchi, Gino Roberto Corazza

W1327

Exaggerated Rectal Tone Response After Meal Intake in Patients with Irritable Bowel Syndrome with Fecal Incontinence Pernilla Jerlstad*, Pia Agerforz, Gisela Ringstrom, Jenny Wallin, Anette Lindh, Hasse Abrahamsson, Magnus Simren

W1328

Plasma 5-Hydroxytryptamine Concentration Varies with Gender and Menstrual Status in Irritable Bowel Syndrome Patients with Diarrhoea (IBS-D) But Not Healthy Volunteers Lesley A. Houghton*, Heather Perry, Julie Morris, Peter J. Whorwell, Brian Keevil

W1329

Characterization of the Fecal Microbiota in Patients with Diarrhea Predominant Irritable Bowel Syndrome. Ian M. Carroll*, Xiang Jun Shen, Temitope O. Keku, R. Balfour Sartor, Yehuda . Ringel

W1330

Meal Induced Symptoms in Patients with Irritable Bowel Syndrome - Clinical and Physiological Characteristics. Yehuda . Ringel*, Amit Ringel, Olafur S. Palsson, Motoyori Kanazawa, William E. Whitehead

W1331

Evidence for An Increased Expression of Serotonin Receptor Type 3 Genes in Irritable Bowel Syndrome with Diarrhea Johannes Kapeller, Lesley A. Houghton, Jutta Walstab, Dorothee Moeller, Heinz Boenisch, Frank Autschbach, Nikolaus Gassler, Christine Fischer, Peter J. Whorwell, Wendy Atkinson, Catherine Fell, Gudrun Rappold, Beate Niesler*

W1332

Opiate Induced Constipation Is Not Associated with Changes in Serotonin Signaling in the Rectal Mucosa As Observed in IBS and Colitis Matthew D. Coates*, Elice M. Brooks, Meagan M. Costedio, Eric K. Ganguly, Doris B. Strader, Michael J. Callahan, Gary M. Mawe, Peter L. Moses

W1333

Candidate Adrenergic, Gnβ3 and Serotonergic Polymorphisms, Endophenotype, Pharmacogenetics of Clonidine in Irritable Bowel Syndrome and Health Michael Camilleri*, Irene Busciglio, Paula Carlson, Sanna McKinzie, Duane D. Burton, Kari Baxter, Michael D. Ryks, Alan R. Zinsmeister

W1335

5httlpr Polymorphism of Serotonin Transporter: Clinical Variants and Symptom Severity in Patients with Irritable Bowel Syndrome Massimo Bellini, Rocchina Colucci, Narcisa Ghisu, Giuseppe Rossi, Dario Gambaccini, Francesco Costa, Santino Marchi, Marcello Tonini, Mario Del Tacca, Corrado Blandizzi*

W1336

Dysbiosis in Diarrhoea-Predominant IBS: Significant Increase in Mucosa-Associated Bacteroides Gareth Parkes*, Neil B. Rayment, Barry Hudspith, Liljana Petrovska, Carlo Nunes, Miranda Lomer, Jonathan Brostoff, Kevin Whelan, Jeremy D. Sanderson

Denotes DDW Poster of Distinction

P-303

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL W1337

Abdominal Symptoms in Patients with Long Qt Syndrome and a “Gain of Function” Mutation in the Nav1.5 Sodium Channel Breg Braak*, Tamira K. Klooker, Dirk Scholvinck, Nynke Hofman, Arthur Wilde, Guy E. Boeckxstaens

W1338

Preliminary Observations of Simultaneous Lactulose Breath Testing (Lbt) and Scintigraphy in Controls: SIBO Is Not SIBO. Jason Bratten, Stewart Spies, Michael P. Jones*

W1339

W E D N E S D A Y MAY 21

W1340

Use of Colonic and Anorectal Manometry Testing to Evaluate Patients with Constipation Refractory to Medical Therapy Linda Anh B. Nguyen*, Amy J. Marincek, William J. Snape

W1349

Physiological Levels of Colonic Elongation Activate Polarized Reflex Pathways That Underlie Slow Transit and Accommodation in the Guinea-Pig Distal Colon Eamonn J. Dickson*, Grant W. Hennig, Hyun-Tai Lee, Peter Bayguinov, Dante Heredia, Nicholas J. Spencer, Terence K. Smith

W1350

The Distribution and Function of Monoacylglycerol Lipase, An Endogenous Cannabinoid Inactivation Enzyme, in the Enteric Nervous System. Marnie Duncan*, Adam D. Thomas, Kamala D. Patel, Daniele Piomelli, Keith A. Sharkey

W1351

In Vitro Electrochemical Detection of Nitric Oxide Produced By Inhibitory Motor Neurons in the Myenteric Plexus of the Guinea Pig Ileum Greg M. Swain*, Bhavik A. Patel, Xiaochun Bian, James Galligan

W1352

Comparison of Inhibitory Motor Innervation in the Primate and Mouse Internal Anal Sphincter Melanie McKechnie*, Naomi Harvey, Caroline A. Cobine, Kathleen Keef

W1353

Gastroduodenal Interdigestive Phase III-Like Contractions Are Mediated Via Ghrelin, While Intestinal Interdigestive Phase III-Like Contractions Are Mediated Via 5-HT in Conscious Rats Hiroshi Taniguchi*, Hajime Ariga, Cindy Chen, Jun Zheng, Kirk A. Ludwig, Christopher R. Mantyh, Theodore N. Pappas, Toku Takahashi

W1354

Evidence for Functional TRPC Channels Underlying Non Selective Cation Currents in Mouse Nodose Ganglion Neurons Sung Jin Park*, Michael Beyak

W1355

Enteric Neurophysiological Mechanisms of Action for Bradykinin-Evoked Mucosal Chloride Secretion in Guinea Pig Small Intestine Mei-Hua Qu*, Xiyu Wang, Xiaohong Sun, Sumei Liu, GuoDu Wang, Fie Zou, Yun Xia, Jackie D. Wood

W1356

Functional Neuroplasticity in Acute Diverticulitis: Differential Regulation of Colonic Excitatory Nerve Pathways By Cyclooxygenase Isoforms Matteo Fornai*, Luca Antonioli, Rocchina Colucci, Roberto De Giorgio, Narcisa Ghisu, Marco Tuccori, Piero Buccianti, Massimo Chiarugi, Antonio Marioni, Mario Del Tacca, Corrado Blandizzi

W1357

Cross-Sectional Study On the Correlation Between PreOperative Azathioprine and Myenteric Plexitis in the Proximal Resection Margins and Affected Crohn's Disease Segment Siew C. Ng*, Gulen Arslan Lied, Farah Sandhu, Michael A. Kamm, Thomas Guenther, Naila Arebi

W1358



Colonic Motility, Myenteric Neuron Density and Nitric Oxide Synthase Neuron Density in Mice with Mutations in Hirschsprung's Disease Susceptibility Genes Rachael R. Roberts, Joel C. Bornstein, Annette J. Bergner, Heather M. Young*

W1359



Effects of Genetic Background On Neural Crest Stem Cells in the Sox10dom Model of Hirschsprung Disease Lauren C. Walters*, Michelle Southard-Smith

W1360

GLP-2 Activates and Stimulates the Growth of Enteric Neurons In Vitro Elaine de Heuvel*, Laurie E. Wallace, Catherine Ivory, David Sigalet

W1361

Intrinsic Inhibitory Postsynaptic Potentials in VIP Neurons of the Guinea-Pig Submucous Plexus Involve the Activation of 5-HT1A and Sst2 Receptors Pei Pei J. Foong*, Joel C. Bornstein

Habitual Constipation in Children: It's All in the Family!! Waseem Ostwani, Mary Rewalt, Yoram Elitsur*

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility

ENS, GLIA AND ECCS Participants will be able to: • Review research about ENS, glia and ECCS. W1341

Hyperglycemia-Induced Enteric Neuronal Apoptosis Is Mediated Through Enhanced Oxidative Stress and TLR4 Signaling Mallappa Anitha*, Amy B. Miller, Bindu P. Chandrasekharan, Simon Mwangi, Matam Vijay-Kumar, Shanthi V. Sitaraman, Andrew T. Gewirtz, Shanthi Srinivasan

W1342



Expression of Gdnf, P-AKT and Enteric Neurons in Colon of Diabetic Rats Du Fan, Cuiping Li, Shi Liu*

W1343



Bone Marrow Stromal Cells Survive Transplantation and Rescue Neurons in Gastrointestinal Tract Denervation Rong Lin*, Zhen Ding, Wei Qian, Song Jun, Xiaohua Hou

W1344



Localized Release of 5-HT Around Fecal Pellets Initiates Migrating Motor Complexes That Drive Propulsion in Murine Colon Terence K. Smith*, Grant W. Hennig, Peter Bayguinov, Eamonn J. Dickson, Dante Heredia

W1345

Cholera Toxin Induces Long-Term Increases in Excitability in VIP and NPY Secretomotor Neurons in Guinea-Pig Jejunum Via a Mechanism Involving 5-HT3 and Nk1 Receptors Rachel Gwynne*, Joel C. Bornstein

W1346

Patterns of Activation of Myenteric Neurons During the Murine Migrating Motor Complex Peter Bayguinov*, Grant W. Hennig, Nicholas J. Spencer, Terence K. Smith

W1347

Strain-Specific Expression of Tph2 Polymorphism in Murine Enteric Neurons Kath B. Neal, Laura J. Parry, Joel C. Bornstein*

W1348

Function of R-Type Calcium Channels in Subsets of Myenteric Neurons in the Guinea-Pig Ileum Vinogran Naidoo*, James Galligan

P-304

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL W1362

The Clinicopathologic Comparison and Novel Classification of Hypoganglionosis and Adult-Onset Hirschsprung's Disease Mi Young Do*, Seung-Jae Myung, Jun-Won Chung, Kee Wook Jung, Soon Man Yoon, Do Hoon Kim, In ja Yoon, Jung eun Ko, Hyun Suk Song, Byong Duk Ye, Jeong-Sik Byeon, Hwoon-Yong Jung, Chang Sik Yu, Suk-Kyun Yang, Jin-Ho Kim

W1372

Colitis Reduces N-Type Ca2+ Current in Neurons from Superior Mesenteric Ganglia Mohamed Motagally, Shadi Neshat, Alan Lomax*

W1373

Importance of CCK (Cholecystokinin) and 5-HT (Serotonin) in Giardia-Induced Post-Infectious IBS Vernesa Dizdar, Robin C. Spiller, Kurt Hanevik, Odd Helge Gilja, Trygve Hausken*

W1363

Real Time Detection and Function of Melatonin Release from the Mucosa of Guinea Pig Ileum Bhavik A. Patel*, Xiaochun Bian, James Galligan, Greg M. Swain

W1374

W1364

Protein Extracts from Hsd Smooth Muscle Allow Enteric Nerve Cell Growth and Survival In Vitro Ulrich Rauch, Markus Klotz, Karl H. Schäfer*

Excitation of Neurons in the Enteric Nervous System (ENS), Degranulation of Enteric Mast Cells and Direct Action On Enterocytes Underlie Stimulatory Action of Bradykinin (Bk) On Mucosal Secretion in Guinea-Pig Small Intestine Guo-Du Wang*, Xiyu Wang, Fie Zou, Yun Xia, Sumei Liu, Mei-Hua Qu, Xiaohong Sun, Wei Ren, Jackie D. Wood

W1365

Axial Stretch Activated Lower Esophageal Sphincter Relaxation Is Caused By the Direct Activation of Inhibitory Motor Neuron in the Myenteric Plexus Yanfen Jiang*, Valmik Bhargava, Ravinder K. Mittal

W1366

Interdigestive Migrating Motor Complex Is Regulated By the Interaction Between Motilin and 5-HT of the Duodenal Mucosa in Conscious Dogs Hitoshi Nakajima, Erito Mochiki, Hiroshi Taniguchi, Hajime Ariga, Cindy Chen, Kirk A. Ludwig, Christopher R. Mantyh, Theodore N. Pappas, Toku Takahashi*

AGA Institute Poster Session 8:00 AM - 5:00 PM

W1375

Nicotine Reduces TLR2 and NOD2, But Not TLR4Induced NF-KappaB Activation in Mouse Spleen Macrophages Esmerij P. van der Zanden*, Guy E. Boeckxstaens, Wouter de Jonge

W1376

Tumor Necrosis Factor Alpha and Interferon Gamma Induce Apoptosis in Enteric Glia: Protective Role of Brain-Derived Neurotrophic Factor Christoph Hartmann, Nadine Degenkolb, Martin Steinkamp, Guido Adler, Georg B. von Boyen*

W1377

Altered Intestinal Paracellular Permeability in H. pylori Infected Mice Is Restored By Bacterial Eradication and Probiotic Treatment Premysl Bercik*, Jun Lu, Elena F. Verdu, Hiromi Sakai, Thomas A. Tompkins, Eishun Tsuchida, Mary H. Perdue, Stephen M. Collins

W1378

Alteration of Cholinergic and Purinergic Neurotransmission in the Inflamed Colon of the Mouse with Food-Induced Allergic Diarrhea Yuxin Leng*, Makoto Kadowaki

W1379

A Cholesterol-Rich Diet But Not Enterohepatic Helicobacter Infection Prolongs Small Intestinal Transit in Mice Meimin Xie*, Kirk J. Maurer, Bian Yu, James G. Fox, Martin C. Carey

W1380

Robust Adverse Effects of Chronic Circadian Desynchronization Seen When Animal Is Challenged with Induced Colitis Fabian Preuss*, Yueming Tang, Fred W. Turek, Ali Keshavarzian

Sails Pavilion San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility

NEUROIMMUNE MODULATION OF GUT FUNCTION, INCLUDING INFECTIONS Participants will be able to: • Review recent research in neuroimmune modulation of gut function, including infections. W1367

W1368

W1369

W1370

W1371

Impaired Steroid Sensitivity of Peripheral Blood Mononuclear Cells in Patients with Irritable Bowel Syndrome Tobias Liebregts*, Julia G. Junne, Birgit Adam, Stuart M. Brierley, L. Ashley Blackshaw, Guido Gerken, Gerald J. Holtmann Immune Activation and Clinical Manifestation of Peptic Ulcer Disease Montri Gururatsakul*, Edmund C. Khoo, Jenny Persson, Ming-Xian Yan, Birgit Adam, Tobias Liebregts, Richard H. Holloway, Nicholas J. Talley, Gerald J. Holtmann Small Bowel Homing T Lymphocytes and Symptom Severity in Patients with Functional Dyspepsia Birgit Adam*, Tobias Liebregts, Stuart M. Brierley, L. Ashley Blackshaw, Gerald J. Holtmann Mucosal Immune Activation in Irritable Bowel Syndrome Is Gender-Dependent and Associated with Digestive Symptoms Cesare Cremon, Luciana Gargano, Roberto De Giorgio, Rosanna Cogliandro, Roberto Corinaldesi, Vincenzo Stanghellini, Giovanni BARBARA* Duodenal Mast Cell Hyperplasia and Nerve Proximity in Irritable Bowel Syndrome Marjorie M. Walker*, Nicholas J. Talley, Mandakini Prabhakar, Coralie J. Pennaneach, Jukka Ronkainen, Pertti Aro, Tom Storskrubb, Alan R. Zinsmeister, William S. Harmsen, Lars Agreus

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Nutrition & Obesity

PREBIOTICS AND PROBIOTICS Participants will be able to: • Discuss the metabolism and role of prebiotic, probiotic, and antibiotics in pathogenesis and treatment of gastrointestinal and other diseases. W1381

Short Chain Fatty Acid Profiles in Plasma and Urine of Healthy Volunteers Depend On the Type of Indigestible Carbohydrate Kristin Verbeke*, Veronique Ferchaud-Roucher, Tom Preston, Alexandra C. Small, Liesbet Henckaerts, Marion Priebe, Roel J. Vonk

Denotes DDW Poster of Distinction

P-305

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL

W E D N E S D A Y

W1382



The Bifidogenic Potential of ArabinoxyloOligosaccharides in Healthy Volunteers Depends On the Degree of Polymerisation Lieselotte Cloetens*, Yasmine Delaedt, Frans Ollevier, Willem F. Broekaert, Christophe M. Courtin, Jan A. Delcour, Paul Rutgeerts, Kristin Verbeke

W1383



The Effect of Two Different Doses of ArabinoxyloOligosaccharides and Oligofructose Enriched Inulin On the Colonic Ammonia Metabolism in Healthy Volunteers Lieselotte Cloetens*, Joost Van Duppen, Willem F. Broekaert, Christophe M. Courtin, Jan A. Delcour, Paul Rutgeerts, Kristin Verbeke

W1384

A Randomized Controlled Trial of Lactobacillus GG in Infantile Diarrhea Sudipta Misra*, Tapas K. Sabui

W1385

The Composition of the Dominant Fecal Microbiota in COPD Patients Receiving Multispecies Probiotics During and After Antibiotic Intake Catherina Koning*, Daisy Jonkers, Hauke Smidt, HermanJan Pennings, Emiel Wouters, Ellen Stobberingh, Reinhold Stockbrugger

W1386

The Effect of a Multispecies Probiotic On the Composition of the Fecal Microbiota and Bowel Habits in COPD Patients Treated with Antibiotics Catherina Koning*, Daisy Jonkers, Linda Tijsseling, Herman-Jan Pennings, Emiel Wouters, Ellen Stobberingh, Reinhold Stockbrugger

W1387

Efficacy of Probiotics in Treatment of Pediatric Atopic Dermatitis: A Meta-Analysis of Randomized, Controlled Trials Sonia Michail*, Gary Onady, Adrienne Stolfi, Thomas Johnson

MAY 21

W1388

Effects of Butyrate On the Colonic Mucus Layer in Healthy Humans Henrike Hamer*, Daisy Jonkers, Freddy Troost, Steven Vanhoutvin, Andrea Kodde, Koen Venema, Ger H. Koek, Robert-Jan Brummer

W1389

Probiotics in Clinical Trials from 2004 to 2007: A Review of Current Literature Adam S. Kim*, Martin H. Floch

W1390

Dynamic, Computer-Controlled In Vitro Fermentation of Alginate-Entrapped Starch Microspheres Using Microflora Obtained from Patients with Inflammatory Bowel Disease Devin Rose*, Ali Keshavarzian, Koen Venema, Bruce R. Hamaker

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

W1393

Is Tumor M2-Pyruvate Kinase (PK) a Potential Marker for the Discrimination Between Chronic Pancreatitis and Pancreatic Cancer? Kerstin Schütte*, Michael Bellutti, Klaus E. Monkemuller, Stefan Kahl, Thomas Wex, Peter Malfertheiner

W1394

Hepatoma-Derived Growth Factor Is a Novel Prognostic Factor for Patients with Pancreatic Cancer Hirokazu Uyama*, Hideji Nakamura

W1395

Serum Tumor Antigen Reg4 As a Diagnostic Biomarker in Pancreatic Ductal Adenocarcinoma Reiko Takayama*, Hidewaki Nakagawa, Akira Sawaki, Nobumasa Mizuno, Yusuke Nakamura, Kenji Yamao

W1396

Adiponectin (ADP): A New Tracer for the Diagnosis of Pancreatic Cancer. (PC) Jean Marc Phelip, Xavier Roblin*, Mathieu Baconnier, Aurelie Durand, Pierre Yves Benhamou

W1397

Characteristics of the Non Insulino-Dependent Diabetes (NIDD) in Pancreatic Cancer (PC): Insulinopenia and Not Insulino-Resistance (Ir) Xavier Roblin*, Mathieu Baconnier, Aurelie Durand, Pierre Yves Benhamou, Jean Marc Phelip

W1398

Description of Incidental Pancreatic Cysts On Magnetic Resonance Imaging and Relationship to Pancreatic Cancer Saburo Matsubara*, Minoru Tada, Takao Kawabe, Takeshi Tsujino, Hiroshi Yagioka, Hirofumi Kogure, Takashi Sasaki, Toshihiko Arizumi, Osamu Togawa, Yousuke Nakai, Naoki Sasahira, Kenji Hirano, Hiroyuki Isayama, Nobuo Toda, Masao Omata

W1399

Pancreatic Cyst, Not New-Onset Diabetes, Is the Clue to Early Diagnosis of Pancreatic Cancer Yousuke Nakai*, Minoru Tada, Yoko Yashima, Hiroshi Yagioka, Hirofumi Kogure, Takashi Sasaki, Toshihiko Arizumi, Osamu Togawa, Yukiko Ito, Saburo Matsubara, Kenji Hirano, Naoki Sasahira, Takeshi Tsujino, Hiroyuki Isayama, Takao Kawabe, Masao Omata

W1400

Diabetes in Pancreatic Cancer Is Not Mediated By Resistin Rahul Pannala*, George Klee, Roy Dyer, William Bamlet, Ananda Basu, Gloria M. Petersen, Thomas C. Smyrk, Suresh T. Chari

W1401

Dose-Dependent Effects of Alcohol and Tobacco On Age of Presentation in Pancreatic Cancer (PC): A Multicenter, International Study Eugene Zolotarevsky*, Randall Brand, Shih-Yuan Lee, Simon Sherman, David C C. Whitcomb, Aaron R. Sasson, Paola Ghiorzo, Henry T. Lynch, Daniel Normolle, Michelle A. Anderson

W1402

Differential Proteomic Analysis of Human Pancreatic Juice from Pancreatic Cancer, Chronic Pancreatitis and Choledocholithiasis Jun Gao*, Feng Zhu, Zhaoshen Li, Shunli Lu

W1403

Pancreatic Lesions of Dysplasia (Panin) Are Observed in Hereditary Pancreatitis (HP): A Pathological Study Vinciane Rebours*, Anne Couvelard, Jean-Yves Scoazec, Jean-François Fléjou, Marie Soubeyrand, Bruno Turlin, Pascal Hammel, Philippe B. Ruszniewski, Philippe Levy

W1404

Accuracy of Endoscopic Ultrasound-Guided Fine Needle Aspiration (EUS-FNA) for the Cytological Diagnosis of Solid Pancreatic Masses and Clinical Impact of On-Site Cytophatological Evaluation Julio Iglesias-Garcia*, Jose Larino-Noia, Elena Eugenyeva, Ihab Abdulkader, Antonio Lozano-Leon, Begoña Vieites, Jeronimo Forteza, Enrique Dominguez-Munoz

Sponsored by: Pancreatic Disorders

PANCREATIC CANCER: RISK FACTORS AND DIAGNOSIS Participants will be able to: • Recognize new developments in the diagnostic approach to the early diagnosis of pancreatic cancer. W1391



Overexpression of Lmo2 in Pancreatic Cancer and Its Clinical Implication As a Therapeutic Target Kohei Nakata*, Eishi Nagai, Kenoki Ohuchida, Yoshihiro Miyasaka, Akifumi Hayashi, Kazuhiro Mizumoto, Masazumi Tsuneyoshi, Masao Tanaka

W1392

Ascorbate-Induced Cytotoxicity in Pancreatic Cancer Joseph Cullen*, Garry R. Buettner, Juan Du, Mark Levine



P-306

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL W1405

Heterogeneity in the Expression of Prognostic Markers in Liver Metastases of Pancreatic Endocrine Tumours Anne Couvelard*, Lydia Deschamps, Philippe Ravaud, Gabriel Baron, Alain Sauvanet, Olivia Hentic, Jacques Belghiti, Pierre Bedossa, Philippe B. Ruszniewski

W1406

Risk Factors for Pancreatic Endocrine Tumors: Multicentre Case-Control Study Gabriele Capurso*, Massimo Falconi, Francesco Panzuto, Maria Rinzivillo, Rossella Bettini, Michela Di Fonzo, Letizia Boninsegna, Sara Cassetta, Vito D. Corleto, Paolo Pederzoli, Gianfranco Delle Fave

W1414

Detection of Chromosomal Aberrations in Intraductal Papillary Mucinous Neoplasms By Comparative Genomic Hybridization Stefan Fritz*, Carlos Fernandez-del Castillo, Mari MinoKenudson, Stefano Crippa, Julie M. Miller, Sarah P. Thayer, Vikram Deshpande, Gregory Y. Lauwers, Andrew L. Warshaw, A. John Iafrate

W1415

Natural History and Morphological Evolution of Pancreatic Serous Cystadenoma (sc) Vinciane Rebours*, Marie-Pierre Vullierme, Alain Aubert, Anne-Laure Pelletier, Olivia Hentic, Frédérique Maire, Pascal Hammel, Philippe B. Ruszniewski, Philippe Levy

W1416

Can EUS-FNA Reliably Predict Continuity Between the Pancreatic Duct and Cystic Lesions? Ketan Kulkarni*, Neal J. Schamberg, Roberto R. Gonzalez, Paul J. Christos, Savreet Sarkaria, Mark Pochapin, Felice Schnoll-Sussman

W1417

Extrapancreatic Malignancies in Patients with Intraductal Papillary Mucinous Neoplasm of the Pancreas - Incidence, Risk Factors, and Comparison with Patients with Other Pancreatic Cystic Neoplasms Won Jae Yoon*, Ji Kon Ryu, Yong-Tae Kim, Yong Bum Yoon



Regiv Expression Is Involved in ‘Intestinal Type' Carcinogenesis of Intraductal Papillary Mucinous Neoplasm of the Pancreas Kohei Nakata*, Eishi Nagai, Kenoki Ohuchida, Yoshihiro Miyasaka, Akifumi Hayashi, Kazuhiro Mizumoto, Masazumi Tsuneyoshi, Masao Tanaka

W1418

Are We Performing Fewer Resections of Low Risk Pancreatic Cysts? Time Trends and Analysis from a Large Cohort Benjamin M. Weinberg*, James J. Farrell, Raymond Tang, David Dawson, Howard A. Reber, Oscar J. Hines, James S. Tomlinson, Brennan M. Spiegel

W1408



Senescence in Intraductal Papillary Mucinous Neoplasms of the Pancreas Yoshihiro Miyasaka*, Eishi Nagai, Kenoki Ohuchida, Kohei Nakata, Akifumi Hayashi, Kazuhiro Mizumoto, Koji Yamaguchi, Masazumi Tsuneyoshi, Masao Tanaka

W1419

W1409

The Incidence of Other Malignancies in Patients with Intraductal Papillary Mucinous Neoplasms of the Pancreas: Emphasis On Whole-Body Surveillance Ikuya Miki*, Hiromu Kutsumi, Tetsuo Ajiki, Ippei Matsumoto, Shiei Yoshida, Yoshinori Morita, Takashi Toyonaga, Masaru Yoshida, Hideto Inokuchi, Shigeto Mizuno, Takeshi Azuma

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Pancreatic Disorders

PANCREATIC DISORDERS: CYSTIC NEOPLASMS AND IPMN Participants will be able to: • Describe the natural history and malignant potential of IPMN and cystic pancreatic neoplasms. W1407

W1410

W1411

W1412

W1413

Risk of Pancreatic Ductal Adenocarcinomas in LongTerm Followed-Up Patients with Branch Duct Intraductal Papillary-Mucinous Neoplasms Satoshi Tanno*, Tomoya Nishikawa, Kazuya Koizumi, Junpei Sasajima, Kazumasa Nakamura, Yusuke Mizukami, Toshikatsu Okumura, Yutaka Kohgo in situ Detection of Vhl/HIF Pathway Proteins Identifies a Pancreatic Endocrine Microadenomatosis in Patients with a Von Hippel-Lindau Disease (Vhl) Périgny Martine*, Pascal Hammel, Olivier Corcos, Stéphane Richard, Alain Sauvanet, Jacques Belghiti, Pierre Bedossa, Philippe B. Ruszniewski, Anne Couvelard Expression of Sox-11 and Sox-4 Is Involved in Pathogenesis of Solid Pseudopapillary Tumor in Pancreas Jae Hee Cho*, Sung Pil Hong, Jeong Youp Park, Tae Joo Jeon, Hee Man Kim, Seungmin Bang, Si Young Song, Jae Bock Chung, Seung Woo Park Proteomic Assessment of Markers for Malignancy in the Mucus of Intraductal Papillary Mucinous Neoplasms of the Pancreas (IPMN) Olivier Corcos*, Anne Couvelard, Alain Sauvanet, Delphine Dargère, Frédérique Maire, Valérie Paradis, Pascal Hammel, Philippe Lévy, Philippe B. Ruszniewski, Pierre Bedossa

Mucinous Cyst Adenocarcinoma (Mca) Has Better Prognosis Compared to Malignant Intraductal Papillary Mucinous Tumor (IPMT) of the Pancreas: Analysis of a Population Based Cancer Registry Ananya Das

ASGE Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

CLINICAL ENDOSCOPIC PRACTICE W1420

Water Infusion in Lieu of Air Insufflation Enhanced Performance of Up-Front Scheduled Unsedated Colonoscopy in United States (US) Veterans Felix W. Leung*, H. S. Aharonian, Joseph W. Leung

W1421

A Prospective, Randomized Trial of Sucralfate Versus Proton Pump Inhibitor On Prevention of Hemorrhage from the Artificial Ulcer After Endoscopic Submucosal Dissection Wan Sik Lee*, Sung Bum Cho, Chang-Hwan Park, YoungEun Joo, Hyun Soo Kim, Sung Kyu Choi, Jong Sun Rew

W1422

Safety of Conscious Sedation During Routine Endoscopy for Patients At Risk for Obstructive Sleep Apnea Vijay S. Khiani*, Santo Maimone, Wajeeh Salah, Linda C. Cummings, Amitabh Chak

W1423

ERCP and EUS Complication Rates Are Not Increased in Elderly Patients Mark E. Benson*, Siobhan Byrne, Patrick R. Pfau, Terrence J. Frick, Mark Reichelderfer, Deepak V. Gopal

W1424

Usefulness of Endoscopic Submucocal Dissection Versus Gastrectomy in Elderly Patients with Early Gastric Cancer Eigo Kojima*, Koichi Tashiro, Takehiro Tajima, Jun Narita, Takao Danzuka, Susumu Tsukahara

W1425

Colonoscopy with Polypectomy in Anticoagulated Patients Daniel Sedehi, Roy M. Soetikno, Shai Friedland*

Denotes DDW Poster of Distinction

P-307

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL W1426

W E D N E S D A Y

Comparison of Endoscopic Submucosal Dissection Using Sodium Hyaluronate and Needle-Knife Versus Endoscopic Mucosal Resection for Colonic Laterally Spreading Tumors Kouichi Nonaka*, Makoto Nishimura, Shuya Yoshinaga, Hideki Kitada, Masahumi Sakaguchi, Ayako Okuda, Yoshi Takekuma, Tetsu Kawaguchi, Michio Hifumi, Hiroto Kita, Hironori Yamamoto

W1440

Endoscopic Interventions in Pancreatic Pseudocysts, Abscesses and Infected Necroses - Experiences and Treatment Results of a Large Single Centre Case Series (N=87) Uwe Will*, Christian Wanzar, Rainer Gerlach, Frank Meyer

W1441

Complications of Colonoscopy in a Large Public County Hospital in Greece. A 10 Year Prospective Study Emmanouil Vardas, Angeliki Theodoropoulou, Maria Manolaraki, Ioanna Charoniti, Aikaterini Mpoumpaki, Nikolaos Papanikolaou, Gregorios Chlouverakis, Gregorios Paspatis*

W1427

Endoscopic Ultrasound-Guided, Transmural Drainage and Necrosectomy in Complicated Acute and Chronic Pancreatitis Palle N. Schmidt

W1428

Multiple Endoscopic Biopsies in Research Subjects: Safety Results from An NIH Series Michael D. Yao*, Erik C. von Rosenvinge, Catherine Groden, Peter Mannon

W1442

Low Incidence of Hyperamylasemia After Proximal Double Balloon Enteroscopy: Adjustment of Insertion Technique Peter B. Mensink*, Jelle Haringsma, E. J. Kuipers

W1429

Clinical Efficacy of Endoscopic Submucosal Dissection in Patients with Comorbid Diseases Beom Jin Kim*, Jae J Kim, Byung-Hoon Min, Won Kyoung Yun, Hoi Jin Kim, Jun Haeng Lee, Dong Kyung Chang, Young-Ho Kim, Hee Jung Son, Poong-lyul Rhee, Jong Chul Rhee, Kyung Mi Kim, Cheol Keun Park

W1443

Chlorhexidine Versus Povidone-Iodine As Cutaneous Antisepsis for Prevention of PEG Site Infection. A Prospective Randomized Pilot Study Waleed Ibrahim*, Raffat Jaber, Christian Holland, Naveen Gupta, Kendrick Che, Snorri Olafsson

W1444

W1430

Prolonged Intestinal Transit: An Important Factor in Non-Obstructive Capsule Retention Nam Q. Nguyen*, Margaret Allen, Kenneth F. Binmoeller

An Alternative to Standard Brushing Procedure Lionel Pineau, Marlene Richard*, Bernard Marchetti

W1445

The Effect of Oral Cola Ingestion for the Endoscopic Inspection of Remnant Stomach - Randomized Case Control Study Moon Kyung Joo*, Beom Jae Lee, Jong-Jae Park, Sehe Dong Lee, Jae Seon Kim, Sang Woo Lee, Young-Tae Bak, Jong Eun Yeon, Kwan Soo Byun, Sung-Soo Park, Young-Jae Mok

W1446

Time of Day As a Risk Factor for Incomplete Colonoscopy: An Australian Tertiary Referral Hospital Experience Geoffrey A. Francis*, Donna Gillies, Douglas Routley

W1447

The Clinical Usefulness of Intravenous Cimetropium Bromide As a Premedication for Colonoscopy : A Randomized Double-Blind Controlled Trial Jue Yong Lee, Sung Jung Kim*, Mi Kyeong Heo, In Suk Park, Hui Suk Jung, Hyun Seo Yun, Jung Eun Lee, Young Sook Oh, Byoung Ho Kim, Young Mook Kim, Chang Soon Choi, Gwang Ho Baik, Jin Bong Kim, Dong Joon Kim

W1448

Appropriateness and Diagnostic Yield of Colonoscopy in Young Women Karen Steveling, Gerald J. Holtmann, Mark Schoeman, Jane M. Andrews*

W1449

Predicting the Presence of Esophageal Varices in Cirrhotic Patients Using MELD, APRI, Child-Pugh Score, Platelets and Liver Function Tests Jean Tafarel*, Luciano Lenz, Fernanda P. Martins, Patricia P. Costa, Rodrigo A. Rodrigues, Frank S. Nakao, Maria Rachel S. Rohr, Ermelindo Della Libera, Angelo P. Ferrari

W1450

Renal Safety of the Bowel Preparations in Subjects with Spinal Cord Injury: A Prospective Randomized Study Ashwani K. Singal*, Alan S. Rosman, Spencer Shaw, Kristel K. Hunt, Marinella Galea, Hanumantha R. Ancha, Maher Jerudi, Run-Lin Zhang, James Post, Ann M. Spungen, William Bauman, Mark A. Korsten

W1451

Should We Be Using Bowel Preparation and Prokinetic Agents for Small Bowel Capsule Endoscopy? A Prospective Randomized Controlled Trial Aymer Postgate*, Aine Fitzpatrick, Neil Patterson, Chris H. Fraser

MAY 21 W1431

Nasal Vs Oro-Nasal Oxygenation and Capnography During Endoscopy Sanjay Ramrakha, Thomas J. Borody*, Kylie J. Herdman, Jordana Campbell, Loraine Holley

W1432

Comparison of Two Methods of Stent Placement in Esophageal Malignant Strictures: with Fluoroscopy and Without Fluoroscopy Take in Consideration the Safe and Efficacy Sérgio A. Barrichello*, Eduardo G. de Moura, Decio S. Couto, Paulo Sakai

W1433

Effects of Omeprazole and Famotidine On Gastric Acidic Environment in Patients with Gastric Neoplasia for 4 Days After Endoscopic Submucosal Desection Jin Yonezawa*, Mitsuru Kaise, Yukinaga Yoshida, Masayuki Kato, Hirobumi Toyoizumi, Noboru Yoshimura, Kenichi Goda, Takuji Yamasaki, Hisao Tajiri

W1434

Frequency of Bacteremia After Endoscopic Submucosal Dissection for Upper Gastrointestinal Neoplasm I-Lin Lee*, Cheng-Shyong Wu, Paul Y. Lin

W1435

Nonsurgical Treatment of Gastric Perforation Complicated By Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection Kwangbum Cho*, SeokGuen Lee, hyunWoong Lee, Jung Min Lee, YoonSeok Hong, Seung Hyun Lee, ByoungKuk Jang, Woo Jin Chung, Kyung Sik Park, Jaeseok Hwang, YuNa Kang

W1436

Risk Factors of Delayed Bleeding After Endoscopic Submucosal Dissection for Gastric Tumors Yutaka Hirayama*, Shu Hoteya, Daisuke Kikuchi, Toshiro Iizuka, Naohisa Yahagi

W1437

Endoscopic Management of Internal Hemorrhoids, Band Ligation or Injection Sclerotherapy? Wael Safwat

W1438

Treatment of Persistent Gastrocutaneous Fistula with Combined Electro-Chemical Cautery and Endoscopic Clips Sushil Duddempudi*, Malvinder Singh, Vishal Ghevariya, Mahesh Krishnaiah, Sury Anand

W1439

Complications of Endoscopic Treatment of Zenker Diverticula Jan Maarten Vrolijk*, Jelle Haringsma, E. J. Kuipers

P-308

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL W1452

W1453

W1454

A Study of Grading System to Evaluate Small Bowel Cleansing for Wireless Capsule Endoscopy Yoon-Tae Jeen, Yong Sik Kim*, Ju Young Kim, Chul Young Kim, Jin Su Jang, Yong Dae Kwon, Sanghoon Park, Bora Keum, Yeon Seok Seo, Hong Sik Lee, Hoon Jai Chun, Soon Ho Um, Sang Woo Lee, Jae Hyun Choi, Chang Duck Kim, Ho Sang Ryu The Clinical Usefulness of Intravenous Cimetropium Bromide As a Premedication for Upper Gastrointestinal Endoscopy Under Conscious Sedation : A Randomized Double-Blind Controlled Trial Young Mook Kim, Sung Jung Kim*, Mi Kyeong Heo, In Suk Park, Hui Suk Jung, Hyun Seo Yun, Jung Eun Lee, Young Sook Oh, Byoung Ho Kim, Jue Yong Lee, Chang Soon Choi, Gwang Ho Baik, Jin Bong Kim, Dong Joon Kim Cold Biopsy Polypectomy: Jumbo Versus Standard Size Biopsy Forceps Ricardo Borsatto*, Camron Kiafar, Francisco C. Ramirez

W1455

Does the Addition of Bisacodyl to PEG-3350 Improve Bowel Cleanliness for Colonoscopy? Audrey H. Calderwood*, Edwin J. Lai, Gheorghe Doros, Brian C. Jacobson

W1456

Risk of Sleep Apnea During Sedation for Endoscopy: Are Current Diagnostic Guidelines Useful? Radha V. Menon*, Mini A. Mathew, David Anjelly, Suleman Iqbal, Joanne Getsy, Asyia S. Ahmad, James C. Reynolds

W1464

Management of Acute Peptic Ulcer Bleeding: A Nationwide Canadian Survey Justin Cheung*, Grant Sawisky, Robert A. Enns, Michael F. Byrne, Norman Marcon, Clarence K. Wong

W1465

Safety of Capsule Endoscopy in the Setting of Implanted Cardiac Defibrillators, Two Years Experience Georg Elias*, Nabil A. Toubia

W1466

A ‘Time and Motion' Study of Endoscopic Practice: Strategies to Enhance Efficiency Gavin C. Harewood*, Alan Coss, Kristia Chrysostomou, Naila Himy, Wai Ling Leong

W1467

Colonoscopy Withdrawal Time - Impact of Polypectomy and Trainee Involvement Deepa K. Shah*, Richard Gerkin, Felix W. Leung, Francisco C. Ramirez

W1468

Endoscope-Guide Infusion of Sodium Phosphate: Efficacy and Safety Comparisons with Polyethylene Glycol Kyu-Jong Kim*, Sun Jung Kim, Jung Sik Choi, Won Moon, Moo In Park, Seun Ja Park

W1469

Does Parental Presence Reduce Anxiety Related to Pediatric Endoscopic Procedures? Christine A. Carter-Kent*, Lori Mahajan, Rita Steffen, Barbara Kaplan, Lisa Feinberg, Robert Wyllie

W1470

Selection of Premedication for Gastrointestinal Endoscopy from the Risk Management Point of View Eiji Umegaki*, Shin-ya Abe, Satoshi Tokioka, Nozomi Takeuchi, Toshihisa Takeuchi, Nanako Shiraishi, Yukiko Yoda, Kazuhide Higuchi

Comparison of Cecal Intubation Rates and Quality of Bowel Preparation Between Morning and Afternoon Colonoscopies Tae Yeob Kim*, Dong Soo Han, Hyun Seok Cho, Tae Jun Byun, Chang Soo Eun, Yong Cheol Jeon, Joo Hyun Sohn

W1471

Influence of Different Procedures of Bowel Preparation On Outcomes of Screening Colonoscopy Giuseppe Feliciangeli*, Paolo Cioccolini, Lucia Di Furia, Cristina Mancini, Mario Rogheto, Maria Teresa Fabi, Danilo Baroncini

W1459

Adjunctive Benefit of Tegasarod with Fleet's Phosphosoda Colonoscopy Preparation: A PlaceboControlled Randomized Study David A. Johnson*, Louise Holmes, Mike Ryan, F Taylor Wootton, Jeff R. Willis, Kelvin Hornbuckle, Whitney D. Brooks, Stacy B. Menees, J Sumner Bell, Michael Doviak

W1472

Bowel Cleansing Prior to Screening Colonoscopy in Persons with Spinal Cord Injury: Lack of Efficacy Using Standard Regimens Hanumantha R. Ancha*, Marinella Galea, William Bauman, Maher Jerudi, Alan S. Rosman, Spencer Shaw, Kristel K. Hunt, Ann M. Spungen, Racine R. Emmons, Ashwani K. Singal, Miroslav Radulovic, Mark A. Korsten

W1460

Understanding and Satisfaction with Care Are Similar in Open-Access and Prior Consultation Patients Undergoing Colonoscopy Michael N. Bernstein*, Emily Ching, Mahsa Mashouf-Fard, Gesine L. Alders, E. Jan Irvine

W1473

W1461

Efficacy of Lukewarm Saline Water and Exercise (Shankh Prakshalana) As Colonoscopy Preparation - A Pilot Study Vijaypal Arya*, Kalpana A. Gupta, Swarn V. Arya

Which Is the Best Bowel Cleanser for Colonoscopy in Mexican Patients? Prospective and Comparative Study to Assess the Efficacy, Safety and Patient Tolerance of Sodium Phosphate Versus Polyethylene Glycol Oscar Teramoto-Matsubara*, José Antonio Vargas, Juan Carlos López Alvarenga

W1474

The Effect of Pre-Treatment with a Proton Pump Inhibitor On the Incidence and Severity of GI Adverse Events Associated with a 4L Polyethylene Glycol + Electrolytes (PEG) Purgative for Colonoscopy Allison Jazwinski*, Steven K. Herrine, Terry Hyslop, Anthony Infantolino, Leo C. Katz, David E. Loren, Cynthia L. Miller, Deborah Moretti, Theodore C. Schroeder, David M. Kastenberg

W1475

Evaluation of Formal Feedback On Endoscopic Competence Among Trainees: The Effect Trial Gavin C. Harewood*, Jan Leyden, Frank E. Murray, Stephen Patchett

W1476

A New Technique for Gastric Endoscopic Submucosal Dissection: Peroral Traction-Assisted ESD Won Joong Jeon*, Il young You, Hee Bok Chae, Seon Mee Park, Sei jin Youn

W1457

Colonoscopy with Polypectomy in Patients Taking Clopidogrel Shai Friedland*, Cynthia W. Leung, Daniel Sedehi, Roy M. Soetikno

W1458

W1462

W1463

The Efficacy, Acceptability and Safety of the New 2l Polyethylene Glycol + Electrolytes + Ascorbic Acid (PEG + E + ASC) Vs the 4L Polyethylene Glycol 3350 + Electrolytes (PEG + E) in Patients Undergoing Elective Colonoscopies in a UK Teaching Hospital Bee C. Lee*, Denise A. Moyes, Jim C. McLoughlin, Peik L. Lim The Safety of Propofol Infusion Compare to Midazolam/ Meperidine for Patients Undergoing Double Balloon Enteroscopy; A Prospective Study Sombat Treeprasertsuk*, Phonthep Angsuwatcharakon, Yuwadee Ponuthai, Rungsun Rerknimitr, Varocha Mahachai, Pinit Kullavanijaya

Denotes DDW Poster of Distinction

P-309

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL W1477

W1478

W E D N E S D A Y

Hemodynamic Efficacy of Sequential Endoscopic Clip Application Using the New Olympus HX-110/610 Reloadable Clipping Device in the Treatment of Spurting Bleedings Juergen Maiss*, Anke Ende, Roland Heide, Markus Wehler, Thomas Bernatik, Eckhart G. Hahn, Dieter Schwab Factors That Influence Colonoscopic Technique and Adenoma Detection Rates At An Academic Gastroenterology Unit Mark E. Benson*, Mark Reichelderfer, Adnan Said, Patrick R. Pfau

W1479

Proficiency of GI Trainees in Achieving Quality Benchmarks in the Performance of Colonoscopy Robert H. Lee*, Denise Kalmaz, Benjamin Brichler, Thomas J. Savides

W1480

Endoscopic Resection of 107 Large Sessile Polyps: Outcome and Predictors of Cure Mouen Khashab*, Michael Rusche, Douglas K. Rex

W1481

Mid-Point Results of a Randomized Blinded Controlled Study of Hands-On Therapeutic Endoscopy Training Adam Haycock*, Siwan Thomas-Gibson

W1482

Endoscopic Submucosal Dissection (ESD) of Large Mucosal and Submucosal Lesions in the GI Tract Rising Experience and Learning Curve in a European Center Andreas Probst*, Helmut Messmann

W1483

Live Demonstrations of the Recent Endoscopic Procedures Using Advanced Network Shigetaka Yoshinaga*, Soichi Itaba, Shinichiro Yada, Shuji Shimizu, Masao Tanaka

W1484

Assessing the Impact of Simulation Training On Endoscopic Hemostasis Skills Robert E. Sedlack

W1485

Clinical Significance of Isolated Peri-Appendiceal Lesions in Patients with Left Sided Ulcerative Colitis Yan Bakman*, Chris Shepela

MAY 21

W1486

Validation of a Novel ERCP Training System with Simulated Fluoroscopy Stefan von Delius*, Philipp Thies, Alexander Meining, Maria Burian, Stefan Wagenpfeil, Christian Prinz, Roland M. Schmid, Eckart Frimberger

W1487

Patient Preferences for the Gender of Their Endoscopist: Implications for the Increasing Female Workforce in Gastroenterology Ponni V. Perumalswami*, Edmund J. Bini

W1488

Large Sessile Adenomas Are Associated with a High Prevalence of Synchronous Neoplasia Douglas K. Rex*, Wissam E. Mattar

W1489

The Incidence of Choledocholithiasis in a Community Setting Zeeshan Perveze*, Chaya Krishnamurthy, Charles W. Duckworth

W1490

W1491

P-310

Documentation of Withdrawal Time Improves Adenoma Detection During Colonoscopy Dong Hyun Sinn*, Dong Kyung Chang, Won-Seok Choi, Jun Haeng Lee, Young-Ho Kim, Hee Jung Son, Poong-lyul Rhee, Jae J Kim, Jong Chul Rhee Training Session Using a Magnetic Imaging Probe in An Ex-Vivo Colon Model Leads to Improved Trainee Colonoscopy Performance Tonya R. Kaltenbach*, Cynthia W. Leung, Kuan K. Wu, Shai Friedland, Roy M. Soetikno

W1492

Tap Water Lavage At Sigmoid Colon: A Simple and Effective Method to Decrease Cecal Inubation Time Deepthi Bollineni*, Vijaypal Arya, Niket Sonpal

W1493

Strategies for Training in Diagnostic Upper GIEndoscopy Juergen Maiss*, Anke Ende, Peter Konturek, Yurdaguel Zopf, Andreas Naegel, Eckhart G. Hahn

W1494

First Experiences with the Olympus Single Balloon Enteroscopy System Lars Helmstaedter*, Dirk Hartmann, Axel Eickhoff, Juergen F. Riemann

W1495

The UK National Endoscopy Training Programme Has Improved Colonoscopy Training Over a Five-Year Period: Closing the Audit Loop Adam Haycock*, Jaymin H. Patel, Siwan Thomas-Gibson

W1496

Face and Construct Validity of a Computer-Based Virtual Reality Simulator for Endoscopic Retrograde Cholangiopancreatography James G. Bittner*, Obinna Ezeamuzie, Toufic Imam, Bruce V. MacFadyen, Robert R. Schade, John D. Mellinger

W1497

Approach to Develop a Competent Training Program for Upper Gastrointestinal Endoscopy Hyoung-Chul Oh*, Hwoon-Yong Jung, Kwi-Sook Choi, Jun-Won Chung, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Jin-Ho Kim

W1498

A New Module of the X-Vision ERCP-Training System for Peroral Cholangioscopy Eckart Frimberger*, Stefan von Delius, Roland M. Schmid, Christian Prinz

W1499

Quality of Colonoscopy Performance Among Gastroenterology and Surgical Trainees: Is There a Need to Standardise Endoscopic Training? Jan Leyden*, Cara M. Dunne, Glen A. Doherty, Subhasish Sengupta, Frank E. Murray, Stephen Patchett, Gavin C. Harewood

W1500

The Amount of Air Left Behind in the Colon Is Positively Related to the Amount of Air Insufflated During Simulated Colonoscopy. Can Rectal Tube Insertion Used in Some Cases Be Avoided Post Colonoscopy? Tariq Mahmood

W1501

Evaluation of Competency and Learning Curve in Colonoscopy Training Bret J. Spier*, Mark E. Benson, Patrick R. Pfau, Greg Nelligan, Eric A. Gaumnitz

W1502

GAGES: A Global Assessment Tool for Evaluation of Technical Performance During Gastrointestinal Endoscopy Melina C. Vassiliou*, Gideon Sroka, Benjamin K. Poulose, Pepa A. Kaneva, Raad Fayez, Brian J. Dunkin, Gerald M. Fried, Jeffrey M. Marks

W1503

The Red Out Time Has No Relation to the Total Time Consumed to Complete Simulated Colonoscopy. Can Red Out Aspect of the Colonoscopy Simulator Be Validated? Tariq Mahmood

W1504

Lack of Trained Endosonographers Is the Main Obstacle for Implementing Endoscopic Ultrasound (EUS) in Clinical Practice in Sweden Evangelos Kalaitzakis*, Riadh Sadik

W1505

Inter-Observer Variations On Interpretation of Capsule Endoscopy and Its Impact On Training Requirements for Competence Sneha John*, Deepak Kejariwal, Crawford P. Jamieson

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL W1506

Moderate Sedation Training Using High-Fidelity Simulation Adam I. Levine, Shefali Sanyal, Andrew E. Dikman, James Aisenberg, Kenneth M. Miller, Lawrence B. Cohen*

W1507

There Is No Association Between Pain and the Amount of Air Insufflated or Left Behind During Simulated Colonoscopy. Pain in Simulation, What Does It Mean? Tariq Mahmood

W1508

Nurse Endoscopists May Take Over Paul G. van Putten*, Monique E. van Leerdam, E. J. Kuipers

W1509

Prospective Results of Endoscopic Ultrasound Drainage of Pancreatic Pseudocysts in a Centre Starting with This Procedure Riadh Sadik*, Claes Jonsson

W1510

W1518

Clinical Experience with a Nitinol Self-Expanding Colonic Stent - Data from the Wallflex-ER Colonic International Registry Ferran Gonzalez-Huix, Paul Goldberg, Jo G. Vandervoort, Søren Meisner*, Dimitrios Xinopoulos, Marc Giovannini, António José Marques, Paul P. Kortan, Alessandro Repici, Truls Hauge, Angelo P. Ferrari, Michael Hünerbein, Purushothaman Premchand, Eric Bartoli, H. Ptok, Mohandas K. Mallath, Bruce Fox

W1519

Prospective Blinded Study of Polyp Size On CT Colonography and Various Endoscopic Measures Courtney Barancin*, Perry J. Pickhardt, David H. Kim, Mary J. Lindstrom, Mark Reichelderfer, Deepak V. Gopal, Patrick R. Pfau

W1520

Analysis of Colonoscopy Withdrawl Time and Detection of Adenomatous Colon Polyp in a High Volume Private Practice Endocenter Dhanasekaran Ramasamy*, Ramanujan Samavedy, Daniel J. Geenen, Ricardo Li, Michael J. Schmalz, Nalini M. Guda, Joseph E. Geenen, Marc F. Catalano

W1521

High-Definition Endoscopy Improves Adenoma Detection Laura K. Bianchi*, Eugene F. Yen, Hemant K. Roy, Michael J. Goldberg, Eric Elton

W1522

Endoscopic Submucosal Dissection Using Hook Knife for Large Colorectal Tumors Kinichi Hotta*, Tsuneo Oyama, Yoko Kitamura, Akiko Takahashi, Akihisa Tomori, Yoshinori Miyata

W1523

Adverse Effects of Colorectal Cancer Screening with Fecal Occult Blood Test: A Population-Based Organized Program Joël Lacroute, Isabelle Gendre, Jean Marc Boyaval, Philippe Perrin, Bernard Denis*

W1524

A Randomized Controlled Trial of the Usefulness of Cap-Fitted Colonoscopy On the Polyp Detection Noriyuki Takano*, Yutaka Yamaji, Haruka Kajiwara, Takafumi Sugimoto, Atsuo Yamada, Masao Akanuma, Goichi Togo, Keiji Ogura, Makoto Okamoto, Haruhiko Yoshida, Takao Kawabe, Masao Omata

Endoscopic Submucosal Dissection for Colorectal Epithelial Neoplasms with Submucosal Fibrosis Shinya Kodashima*, Mitsuhiro Fujishiro, Osamu Goto, Satoshi Ono, Masao Omata

W1525

Comparison of the Performance Characteristics of Endoscopic Submucosal Dissection with Laparoscopic Assisted Colectomy for En-Bloc Resection of Colorectal Neoplasm Shinsuke Kiriyama*, Yutaka Saito, Takahisa Matsuda, Takeshi Nakajima, Tsuyoshi Kikuchi, Seiichiro Yamamoto

Should We Apply Targeted Indigo Carmine (IC) On Colonic Polyps? A Prospective, Multicenter Study Adolfo Parra-Blanco*, David Nicolás-Pérez, Antonio Z. Gimeno-Garcia, José C. Marin-Gabriel, Santos Santolaria, Juan-Antonio Diaz-Acosta, Alejandro Jimenez-Sosa, Alejandro Franco-Ugidos, Enrique Quintero, maria pellise

W1526

Bridge to Surgery Stenting in Patients with Malignant Colonic Obstruction Using the Wallflex Colonic Stent: Report of a Prospective Multicenter Registry Javier Jiménez-Pérez*, Juan Antonio Casellas, Jesus GarcíaCano, Alberto Alvarez, Javier Barcenilla, Pedro González, Enrique Vázquez, Leopoldo López-Roses, Luis Yuguero

W1527

Screening for Colorectal Neoplasia in Those Undergoing Evaluation for Solid Organ Transplantation: Does It Alter the Clinical Management? Moises Garcia*, Ramanujan Samavedy, Susan Partington, Jeffery Steers, Marc F. Catalano, Joseph E. Geenen, Nalini M. Guda

W1528

A Female Predominance in the Time-Dependent Proximal Sfift in Colorectal Cancer in the USA Graham Barnard, Jay J. Yamin*

W1529

Endoscopic Decision of Complete Resection Is More Practical Than Pathologic Decision in the Endoscopic Resection for Rectal Carcinoids Cheol Hee Park*, Dong Kyung Chang, Sang Kil Lee, Jin-Oh Kim, Byung-Ik Jang, Jeong Eun Shin, Sung Jae Shin, Yoon Tae Jeen, Jeong-Seon Ji, Suck-Ho Lee, Sung-Ae Jung, Dongil Park, Chang Soo Eun, Il Hyun Baek

Construct Validity of the Simbionix GI Mentor II Endoscopy Simulator for GI Fellow Trainees in Colonoscopy Jenifer R. Lightdale*, Meghan E. Fredette, Paul A. Rufo, Victor L. Fox, John R. Saltzman, John M. Poneros

ASGE Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

COLON AND RECTUM W1511

W1512

W1513

W1514

Comparative Study of Conventional Colonoscopy and Pan-Colonic Narrow-Band Imaging System in the Detection of Neoplastic Colonic Polyps: A Randomized, Controlled Trial Takuya Inoue*, Mitsuyuki Murano, Naoko Murano, Takanori Kuramoto, Ken Kawakami, Yosuke Abe, Eijiro Morita, Ken Toshina, Yutaro Egashira, Eiji Umegaki, Kazuhide Higuchi

Examination of Current Colorectal Cancer Screening Practices: Are We Adherent to American Gastroenterological Association (AGA) Guidelines? Paul Crainich*, Eric K. Ganguly, Richard Zubarik

W1515

Effect of Institution-Wide Policy of Colonoscopy Withdrawal Time ≥ 7minutes On Polyp Detection Marcelo S. Cury*, Mandeep S. Sawhney, Siwar Albashir, Naama Neeman, Long H. Ngo, Douglas Pleskow, Ram Chuttani

W1516

Localisation of Colorectal Tumour At Colonoscopy ; Do We Know Where We Are? Benjamin J. Colleypriest*, Peter Marden, Amy R. Nicol, Bhavesh Doshi, John D. Linehan

W1517

Proximal Hyperplastic Polyps: Prevalence and Association with Advanced Neoplasia and Tubular Adenomas in the VA Cooperative Study Program #380 Mitchal A. Schreiner*, David G. Weiss, David A. Lieberman

Denotes DDW Poster of Distinction

P-311

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL

W E D N E S D A Y

W1530

Colonoscopy Use in Medicare Beneficiaries Reflects 4Year Mortality Risk Deepika Laxmi Koya*, William Moran, Mark H. DeLegge, John J. Chen, Brenda Hoffman

W1531

Colonoscopic Features of Sessile Serrated Polyps Kazutomo Togashi*, Koji Koinuma, David G. Hewett, Kevin Spring, Hisanaga Horie, Yoshikazu Yasuda, Mark N. Appleyard, Jeremy Jass, Barbara A. Leggett

W1532

Depressed Type Early Colorectal Carcinomas Orie Takemura*, Nobunao Ikehara, Hiroshi Kashida, Yasutoshi Kobayashi, Shigeharu Hamatani, Shin-ei Kudo

W1533

Novel Optical Imaging Techniques for Diagnosis of Colorectal Adenoma - A Prospective Case Study On Detection of Colorectal Adenomas Using AFI Compared with NBI Haruhisa Suzuki*, Yutaka Saito, Takahisa Matsuda, Takeshi Nakajima, Tsuyoshi Kikuchi

W1534

Risk Factors for Delayed Bleeding After Endoscopic Resection for Large Colorectal Tumors Shusei Fukunaga*, Yutaka Saito, Takahisa Matsuda, Takeshi Nakajima, Tsuyoshi Kikuchi

W1535

Dysplasia Detection of Colonic Polyps and Polypectomy Sites Using An Optical Biopsy™ System Mary L. Krinsky*, Samuel B. Ho

W1536

Clinical Significance of Image-Enhanced Endoscopy, Autofluorescence Imaging (AFI) Observations in Differentiation Between Colonic Neoplastic Lesions and Non-Neoplastic Lesions Hiroyuki Aihara*, Shoichi Saito, Hiroshi Arakawa, Mitsuru Kaise, Hisao Tajiri, Masahiro Ikegami

MAY 21

W1537

A Training Session On Polyp Pit Pattern Morphology Does Not Improve the Accuracy of Predicting Polyp Histology Kandarp Patel*, Francisco C. Ramirez, Richard Gerkin, Nooman Gilani

W1538

Polyp Detection Rates Do Increase with the Use of High Definition, Wide-Angle Colonoscopes Adam C. Randolph*, Tony Merrill, Richard Gerkin, Francisco C. Ramirez, Nooman Gilani

W1539

Wide-Angle Colonoscopy Significantly Improves Polyp Detection Rate J. Haringsma*, Lieke Hol, M. E. Leerdam van, E. J. Kuipers

W1540

Colorectal Cancer - How Many Biopsies? Benjamin J. Colleypriest*, Peter Marden, Amy R. Nicol, Lachlan Ayres, Bhavesh Doshi, John D. Linehan

W1541

Endoscopic Submucosal Dissection Using the Newly Developed Ball-Tip Bipolar Current Needle Knife Is Safe and Effective Technique for Large Colorectal Tumors Yutaka Saito*, Haruhisa Suzuki, Tsuyoshi Kikuchi, Takahisa Matsuda, Toshio Uraoka, Masakatsu Fukuzawa

W1542

W1543

W1544

P-312

Accuracy of Capillary Pattern Classification Using NBI Magnification for Diagnosis of Colorectal Lesions Hiroaki Ikematsu*, Kazuhiro Kaneko, Daisuke Fukuda, Takahiro Horimatsu, Kuang I. Fu, Atsushi Ohtsu, Yasushi Sano Efficacy of a Novel Bowel Preparation (PEG-3350 + Gatorade + Bisacodyl) Compared with Conventional PEG-ELS (Golytely) for Bowel Cleansing Prior to Colonoscopy Frederick K. Shieh*, Naresh T. Gunaratnam, Sagal O. Mohamud, Latoya Kuhn, Philip S. Schoenfeld Delay in Colonoscopy Diagnosis of Colon Cancer Amanpal Singh*, Daniel H. Freeman, Taylor S. Riall, Gottumukkala S. Raju

W1545

The Diagnosis of Colorectal Lesions with Magnifying Narrow Band Imaging (NBI) System Yoshiki Wada*, Hiroshi Kashida, Nobunao Ikehara, Kunihiko Wakamura, Ken-ichi Mizuno, Shigeharu Hamatani, Shin-ei Kudo

W1546

Adenomatous Detection Rates of Internist-Performed Sigmoidoscopy in a Veterans Affairs Medical Center Mary L. Krinsky*, Shanglei Liu, Samuel B. Ho

W1547

Variability in Adenoma Detection Rate Among Endoscopists in Screening Sigmoidoscopy Carlo Senore*, Mario Fracchia, Paola Armaroli, Nereo Segnan

W1548

Evaluation of Computed Tomographic Colonography for Colorectal Laterally Spreading Tumors Yasuo Kakugawa*, Yutaka Saito, Gen Iinuma

W1549

Clinical Course of Submucosal Colorectal Cancers Treated By Endoscopic Mucosal Resection Byong Duk Ye*, Jeong-Sik Byeon, Seunghyun Kwon, Benjamin Kim, Seung-Jae Myung, Suk-Kyun Yang, Jin-Ho Kim

W1550

The Effectiveness of Stent Placement for Palliative Treatment in Malignant Colorectal Obstruction and the Predictive Factors Associated with Stent Reobstruction Sang Woo Kim*, Jung Pil Suh, Yu Kyung Cho, Jae Myung Park, In Seok Lee, Hwang Choi, Sok Won Han, Kyu Yong Choi, In-sik Chung

W1551

Incidental Colorectal Findings of PET/CT Scan in Patients with Malignancies Other Than Colorectal Cancer Kiyoko Yoshino*, Naomi Kakushima, Kouichi Nonaka, Akira Aso, Masamitsu Nakao, Shin Arai, Keiko Ishikawa, Shigeki Yamaguchi, Yoshihide Otani, Hiroto Kita

W1552

Risk Factors for Missed Advanced Adenomas Angel Ferrandez*, Federico Sopena, Marcos Diez, Angel I. Lanas

W1553

Earlier Mean Age of Occurrence of Depressed Colorectal Neoplasia in Comparison to Patients with Their Polypoid Counterpart- Undiscovering the Non-Polypoid Route of Colorectal Cancer Claudio R. Teixeira*, Cibele Canali, Ronaldo J. Torresini, Julio C. Pereira Lima, Mauro Maia, Eunice B. Tonelotto

W1554

A Prospective Study of the Prevalence of Colorectal Adenomas in Hispanic Immigrants Referred for Screening Colonoscopy David Kerman*, Ali Albaqali, Amar R. Deshpande, Afonso C. Ribeiro

W1555

Removal and Retrieval of Small Colon Polyps By Cold Snare Polypectomy J. Haringsma*, H. van Dekken, E. J. Kuipers

W1556

Predictive Value of Alarm Symptoms in Colorectal Cancer Diagnosis Federico Tobal*, Valeria Pogorelsky, Daniel Tobal

W1557

Type V Pit Pattern and Submucosal Invasion of Early Stage of Colorectal Neoplasm Shin-ei Kudo*, Yasutoshi Kobayashi, Nobunao Ikehara, Hiroshi Kashida, Shigeharu Hamatani, Orie Takemura, Hiroshi Kanie, Hideyuki Miyachi, Yui Kudo, Kazuo Ohtsuka, Kenichi Mizuno

W1558

Magnifying Endoscopic Findings and Clinicopathological Features of the Colorectal Serrated Adenoma Nobunao Ikehara*, Shin-ei Kudo, Shigeharu Hamatani, Hiroshi Kashida

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL W1559

Proximalisation of Colorectal Carcinoma: A Ten-Year Study in Italy Alberto Comino, Mirella Fortunato, Fulvio Pomero, Chiara Brignone, Cristina Serraino, Christian Bracco, Elena Migliore, Cora Luchino, Adele Cardellicchio, Luigi Fenoglio*

W1571

Usefulness of Ultrasound Elastography in Ulcerative Colitis Daisuke Ishikawa*, Takafumi Ando, Osamu Watanabe, Osamu Maeda, Kazuhiro Ishiguro, Motofusa Hasegawa, Shinya Kondo, Tsuyoshi Kato, Naoki Ohmiya, Yoshiki Hirooka, Yasumasa Niwa, Hidemi Goto

W1560

Adenoma Detection Rates On Screening Colonoscopy in Average Risk Patients At a Large, Rural Tertiary Care Center Duane E. Deivert*, Amitpal Johal, H Lester Kirchner, Nicholas A. Inverso

W1572

Resistant Proctitis and Ulcerative Appendicitis - A Link? Terry Bolin*, Shing Wong, Roger Crouch

W1573

Clinical Course of Intestinal Behçet'sDisease According to Colonoscopic Findings Sung Jae Shin*, Min Cheul Kim, Dong Hun Kim, Jae Chul Hwang, Kee Myung Lee, Kwang Jae Lee, Jin Hong Kim

W1574

Interobserver and Intra-Observer Consistency in the Endoscopic Agreement of Ulcerative Colitis Activities Using Various Classifications Taro Osada*, Toshifumi Ohkusa, Tetsuji Yokoyama, Tomoyoshi Shibuya, Naoto Sakamoto, Kazuko Beppu, Yuji Shimada, Makiko Takada, Kumiko Tamaki, Akihito Nagahara, Tatsuo Ogihara, Sumio Watanabe

W1575

Cytomegalovirus Infection in Patient with Refractory Ulcerative Colitis : Prevalence, Outcome and Therapeutic Effect of Antiviral Treatment Mitsuyuki Murano*, Ken Toshina, Kumi Ishida, Ken Kawakami, Yousuke Abe, Takuya Inoue, Naoko Murano, Eijiro Morita, Kazuhide Higuchi

W1561

W1562

W1563

Stool DNA Testing for Colorectal Cancer Screening in Korean Patients Dongil Park*, Yoo Hum Baek, Sung Keun Park, Young Jin Kim, Sun Jeung Byun, Yong Sung Kim, Wha Mok Kim, Jung Ho Park, Hongjoo Kim, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim Flat Adenomas: The Predominant Lesion in HNPCC Carriers? Robert Hüneburg*, Frank Lammert, Christian Rabe, Nils Rahner, Tilman Sauerbruch, Philip Kahl, Christof Lamberti The Frequency and Risk Factors of Colorectal Adenoma in Health Check Up Subjects of South Korea: Relation to Obesity and Metabolic Syndrome Chang Hwan Choi*, Hong Ju Moon, Sang Joong Kim, Jang Sik Mun, Hyun Woong Lee, Hyung Joon Kim, Jae Hyuk Do, Sae Kyung Chang

W1564

Correlation of Serum Iron Levels and Colonic Adenomas Newton P. Muthunayagam*, Shailendra S. Chauhan, James E. Rohrer, Stephen E. Wright

W1565

Endoscopists Trained in the Diagnosis of Nonpolypoid (Flat and Depressed) Colorectal Neoplasms Detect More Adenomatous Lesions Venkat Kalidindi, Tonya R. Kaltenbach*, Shai Friedland, Roy M. Soetikno

W1566

W1567

W1568

W1569

W1570

Immunological Fecal Occult Blood Test Versus Serum Ferritin for the Detection of Colorectal Neoplasia in An Asymptomatic Population At High Risk for Cancer Ivanhoe Larracilla-Salazar*, Angelica I. Hernandez-Guerrero, Eduardo Fenocchi, Juan Octavio Alonso-Larraga, Sergio R. Sobrino-Cossío Surveillance Colonoscopy Before Scheduled: Is It Worthwhile? Daniel G. Cimmino*, Lisandro Pereyra, Pablo Luna, Sergio J. Berón, Guillermo Horrisberger, Sandra Lencinas, Nicolás Rotholtz, Carlos Peczan, Silvia Pedreira, Luis A. Boerr Self-Expandable Metal Stents in the Management of Benign and Malignant Colorectal Obstruction Jeffrey H. Lee*, Raquel E. Davila, William A. Ross, Marta L. Davila Fluorescence Endoscopy for Further Workup of Neoplastic Lesions in Ulcerative Colitis Using Local 5Aminolaevulinic Acid-Induced Photosensitization Nobuyuki Hida*, Kenji Watanabe, Nobuhide Oshitani, Tetsuo Arakawa, Takayuki Matsumoto Confocal Microendoscope Images Provide Information Equivalent to Histological Findings in Inflammatory Bowel Disease Osamu Watanabe*, Takafumi Ando, Osamu Maeda, Kazuhiro Ishiguro, Daisuke Ishikawa, Motofusa Hasegawa, Shinya Kondo, Tsuyoshi Kato, Naoki Ohmiya, Yasumasa Niwa, Hidemi Goto

W1576

Is Scheduled Maintenance Treatment with Infliximab Cost Effective in Patients with Crohn's Disease? James O. Lindsay*, Yogesh Punekar, James Morris, Guy Chung-Faye

W1577

Deriving Preference Based Utilities for IBD Patients: Converting IBDQ Into EQ-5D Utilities Francesc Casellas, Yogesh Punekar*, James Morris

W1578

The Utility of Double Balloon Endoscopy and Endoscopic Balloon Dilatation Therapy for Crohn's Disease Yutaka Endo*, Yuichiro Kuroki, Takataro Fukuhara, Kazuaki Inoue, Makoto Yoshiba

W1579

Increased Thrombin Generation in Inflammatory Bowel Diseases Valeria Saladino*, Federica Villa, Veena Chantarangkul, Simone Saibeni, Maurizio Vecchi, Savino Bruno, Roberto de Franchis, Cinzia Sei, Pier Mannuccio Mannucci, Armando Tripodi

W1580

A Clinical-Endoscopic Risk Score to Predict Outcome in Acute Lower Intestinal Bleeding (LIB) Jordi Guardiola*, Francisco Rodriguez-Moranta, Ana Berrozpe, Mireia Peñalva, Josep M. Botargues, Antonio Soriano-Izquierdo

W1581

Efficacy and Safety of a Novel Endoscopy-Guided Formalin Irrigation in the Treatment of Hemorrhagic Radiation Proctopathy: Philippine Experience Wilfredo Benjamin Q. Reyes

W1582

External Validation of the Strate's Predictive Model of Severity in Lower Intestinal Bleeding Ana Berrozpe*, Francisco Rodriguez-Moranta, Jordi Guardiola, Mireia Peñalva, Josep M. Botargues, Antonio Soriano-Izquierdo

W1583

Colonic Mucosal Disorder Associated with Low-Dose Aspirin: A Case-Control Study Tomoyoshi Shibuya*, Toshifumi Ohkusa, Tetsuji Yokoyama, Kazuko Beppu, Naoto Sakamoto, Akihiko Kurosawa, Taro Osada, Akihito Nagahara, Michiro Otaka, Tatsuo Ogihara, Sumio Watanabe

Denotes DDW Poster of Distinction

P-313

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL W1584

Endoscopic Evaluation and Management of Colonic Postpolypectomy Hemorrhage Joseph Chen*, Amandeep K. Shergill, Kenneth R. McQuaid, James C. Ryan, Janak N. Shah

W1585

Is Argon Plasma Coagulation the Optimal Treatment for Rectal Bleeding After Radiotherapy? George Karamanolis*, Theodora Kalli, Nikos Misailidis, Zaharias Tsiamoulos, Dimitrios Polymeros, Konstantinos Triantafyllou, Spiros D. Ladas

W1586

W E D N E S D A Y MAY 21

Evaluation of the Efficiency of Urgent Colonoscopy to Treat Bleeding from a Colorectal Diverticulum Hiroaki Suda*, Sayo Itoh, Iruru Maetani

W1599

Sigmoideoscopy in Diagnosis of Gastrointestinal Graft Versus Host Disease in Patients After Allogeneic Bone Marrow Transplantation - Three Years Experiences Ales Novotny*, Marketa Markova, Ludek Voska, Antonin Vitek, Milan Lukas

W1600

Diagnosing Functional Disorders of the Lower Gastrointestinal Tract Clinically:Are We Moving Nearer or Farther? Jijo V. Cherian, Arun Kumar Muthusamy*, Jayanthi Venkatraman

W1601

Comparison of the Efficacy, Tolerability and Safety of PEG Solution (FORTRANS®) with Simethicone Vs Conventional Method of Preparation Before Colonoscopy: A Multicentre Study Boris Poddubny, Sergey V. Kashin*, Leonid Shubin, Vitaly Goncharov, Sergey Mazurov, Alexander Agamov

W1587

The Role of Flexible Sigmoidoscopy in Acute Lower GI Bleeding Rebecca McKay*, Deirdre McNamara

W1588

Argon Plasma Coagulation for the Treatment of Radiation Induced Proctitis María Laura Gonzalez, Marina Cariello, Carlos Alberto Macías Gómez*, Fernando Van Domselaar, Jorge R. Dávolos

W1602

Pharmacokinetic Modelling of a Healthy Volunteer Study for the Assessments of the Ascorbic Acid Effects in PEG+E Containing Gut Cleansing Solutions Hans-Jurgen Gruss

W1589

Colonoscope Position Detecting System's Impact On Patient-Based Comfort and Efficiency of Colonoscopy in Difficult-to-Insert Cases Morio Takahashi*, Yasumi Katayama, Hajime Kuwayama

W1603

Large Colorectal Polyps: Endoscopic Resection and Rate of Malignancy. Does Size Matter? Firas Al-Kawas, Naveen Gupta*, Stanley B. Benjamin, Sushil Ahlawat

W1590

Does the Colonic Capsule PillCam Colon® Efficiently Screen Patients Who Would Deserve a Complete Colonoscopy for Colo-Rectal Cancer Screening? Michel Delvaux*, Muriel Frederic, Isaac Fassler, Gerard Gay

W1604

Colonic Mass in Patients with AIDS: An Expanded Differential Diagnosis Xinqing Fan*, Larry D. Scott, Suimin Qiu

W1591

Appropriateness of Colonoscopy for Patients with Isolated Abdominal Pain Nick Powell*, Joel Dunn, Thomas A. Treibel, Joel Mawdsley, Julian P. Teare, Rupert Negus, Jonathan M. Hoare, Huw J. Thomas, Timothy Orchard

W1605

Efficacy and Safety of Endoscopic Balloon Dilation of Benign Anastomotic Strictures After Oncologic Anterior Rectal Resection — Report On 24 Cases Sergio E. Araujo*, Adriana F. Costa, Victor E. Seid

W1592

Clinical Presentation and Non-Surgical Management of Colonic Perforations Complicating Endoscopic Submucosal Dissection Kyoung Hoon Rhee*, Jeong-Sik Byeon, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jin-Ho Kim

W1593

Use of Electromagnetic (EM) Colonoscope to Assess Maneuvers Associated with Cecal Intubation Russell I. Heigh*, James A. Prechel, Billie J. Horn, Sara San Miguel, Evelyn G. Heigh, John K. DiBaise, Jonathan A. Leighton, Cynthia J. Edgelow, David E. Fleischer

W1594

Propofol Versus Conscious Sedation Use and the Yield of Lesions Found During Initial Screening Colonoscopy Cherag Daruwala*, Giancarlo Mercogliano, Melissa Morgan

W1595

Effectiveness and Safety of Self Expanding Metal Stents for Colonic Obstruction Due to Extra-Colonic Malignancies Kunal Gupta, Jesse P. Houghton, Eric Shen, Tamir BenMenachem*

W1596

Transanal Endoscopic Microsurgery Performed By a Medical Gastroenterologist Shyam Varadarajulu*, Ernesto R. Drelichman

W1597

Public Perception of the PillCam Colon Versus Colonoscopy Wun-Chung Teoh*, Shehan Abey, Marie Ooi, Jenny McDonald

W1598

P-314

Successful Treatment of Anastomotic Leakage After Lower Anterior Rectum Resection (LAR) By Endoluminale Polyurethane (PU)-Sponge Vacuum Therapy Bodo Schniewind*, Frank Bokelmann, Volker Kahlke, Jan H. Egberts, Clemens Schafmayer, Horst Grimm, Fred Faendrich

ASGE Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

ERCP PANCREAS W1606

Sclerosing Cholangitis Affecting the Hilar Bile Duct Is Associated with a Cancer Risk in Cases with Autoimmune Pancreatitis kensuke kubota*, Masahiko Inamori, Hironori Mawatari, Atsushi Nakajima

W1607

Endoscopic Duodenal Papillary Features in Cases of Sclerosing Cholangitis Caused By Autoimmune Pancreatitis Differentiated from Those in Cases of Primry Sclerosing Cholangitis kensuke kubota*, Hironori Mawatari, Atsushi Nakajima

W1608

Three Clinicopathological Subtypes of Autoimmune Pancreatitis Stratified By the Duodenal Papillary Findings and the Serum IgG4 kensuke kubota*, Masahiko Inamori, Atsushi Nakajima

W1609

Easy Access to the Pancreatic Duct Via the Minor Papilla: The Pancreatic Rendez-Vous Technique Pietro Familiari*, Federico Iacopini, Massimiliano Mutignani, Andrea Tringali, Cristiano Spada, Michele Marchese, Vincenzo Perri, Guido Costamagna

W1610

Is Low Serum Lipase of Predictive Value for Diagnosing Early Chronic Pancreatitis in Patients with Refractory Sphincter of Oddi Dysfunction (SOD)? Ayman M. Abdel Aziz*, Ursula M. Pohlmann, Lee McHenry, Evan L. Fogel, James L. Watkins, Stuart Sherman, Glen A. Lehman

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL W1611

3 Fr Prophylactic Pancreatic Stent: What Is the Optimal Stent Length? Ayman M. Abdel Aziz*, Lee McHenry, Evan L. Fogel, James L. Watkins, Stuart Sherman, Glen A. Lehman

W1612

Differentiation Between Autoimmune Pancreatitis and Pancreatic Carcinoma By Endoscopic Retrograde Cholangiopancreatography (ERCP) Takayoshi Nishino*, Fumitake Toki, Keiko Shiratori

W1613

Temporary Placement of Covered Self-Expandable Metal Stent (CSEMS) in the Pancreatic Duct for Management of Painful Chronic Pancreatitis: Preliminary Data Bryan Sauer*, Jayant P. Talreja, Kristi Ellen, Jennifer Ku, Vanessa M. Shami, Michel Kahaleh

W1614

Pancreatic Duct Stenting for Painful Chronic Pancreatitis: Does Size Matter in Preventing Hospitalization? Bryan Sauer*, Vanessa M. Shami, Jennifer Ku, Kristi Ellen, Michel Kahaleh

W1615

Allopurinol to Prevent Pancreatitis After Endoscopic Retrograde Cholangiopancreatography (ERCP): A Randomized Placebo-Controlled Trial Joseph Romagnuolo*, Robert J. Hilsden, Gurpal S. Sandha, Martin J. Cole, Sydney Bass, Gary R. May, Jonathan R. Love, Vincent G. Bain, John P. McKaigney, Richard Fedorak

W1616

W1617

W1618

W1619

W1620

W1621

W1622

W1623

W1624

Effect of Intraductal Secretin Test On the Rates of PostERCP Pancreatitis in Patients with Suspected Sphincter of Oddi Dysfunction (SOD) But Normal Sphincter of Oddi Manometry (SOM) Abdo M. Saad*, Evan L. Fogel, Lee McHenry, James L. Watkins, Stuart Sherman, Furqaan Ahmed, Pradermchai Kongkam, Glen A. Lehman

W1625

A Meta-Analysis of NSAIDs in the Prevention of PostERCP Pancreatitis B. Joseph Elmunzer*, Akbar K. Waljee, Grace H. Elta, Jason Taylor, Syed M Abbas Fehmi, Peter D. Higgins

W1626

Severity of Post-ERCP Pancreatitis Directly Proportional to the Invasiveness of Endoscopic Intervention: A Pilot Study in a Canine Model Jonathan M. Buscaglia*, Brian Simons, Brent J. Prosser, Dawn Ruben, Samuel A. Giday, Priscilla Magno, John O. Clarke, Eun Ji Shin, Anthony N. Kalloo, Kathleen Gabrielson, Sanjay B. Jagannath

W1627

Extent of Pancreatic Duct Opacification and Post-ERCP Pancreatitis Shahzad Iqbal*, Prashant Sharma, Shashin Shah, Peter D. Stevens

W1628

Post ERCP Pancreatitis: Differences in Outcomes Between Long and Short Pancreatic Duct Stents Shahzad Iqbal*, Prashant Sharma, Shashin Shah, Vasudha Dhar, Stavros N. Stavropoulos, Peter D. Stevens

Fatty Pancreas- A Risk Factor for the Development of SOD-Pancreatitis Abhishek Mathur*, Kumar Sandrasegaran, Nicholas J. Zyromski, Megan B. Marine, Stuart Sherman, Glen A. Lehman, Henry A. Pitt

W1629

Can Wire-Guided Cannulation (WGC) Prevent PostERCP Pancreatitis? A Prospective Randomized Trial Do Hyun Park*, Tae Hoon Lee, Ji-Young Park, Jeong Hoon Park, Suck-Ho Lee, Il Kwun Chung, Hong-Soo Kim, SangHeum Park, Sun-Joo Kim

The Comparison of Post Pancreatic Sphincterotomy Pancreatitis Using Needle Knife (NK) Versus Monofilament Traction Sphincterotome (TS) Ramanujan Samavedy*, Dhanasekaran Ramasamy, Joseph E. Geenen, Marc F. Catalano

W1630

Monoclonal Change of K-RAS Mutation in Intraductal Papillary Mucinous Neoplasms (IPMN) Correlates Malignant Progression Osamu Mizuno*, Hirofumi Kawamoto, Ryo Harada, Hironari Kato, Ken Hirao, Naoko Kurihara, Etsuji Ishida, Tsuneyoshi Ogawa, Kazuhide Yamamoto

W1631

Two Center United States Experience with Direct Endoscopic Necrosectomy for the Treatment of Walled Off Pancreatic Necrosis Timothy B. Gardner*, L. C. Levy, Prabhleen Chahal, Santhi Swaroop Vege, Mark D. Topazian, Christopher J. Gostout, Bret T. Petersen, Naoki Takahashi, Stuart R. Gordon, Todd H. Baron

W1632

Long-Term Following Up in Patient with IPMN from Aspect of Carcinogenesis and Organ Cancers Nobuhito Ikeuchi*, Takao Itoi, Atsushi Sofuni, Fumihide Itokawa, Kentarou Ishii, Toshio Kurihara, Syujirou Tsuji, Takayoshi Tsuchiya, Takashi Kawai

W1634

Fully-Covered Self-Expandable Metallic Stents Facilitate Effective Endoscopic Pancreatic Necrosectomy Andrew Y. Wang*, Steven L. Condron, Roman Galysh, Paul Yeaton

5 Fr Prophylactic Pancreatic Stents Are Easier to Place and Require Fewer Guide Wires Than 3 Fr Stents Syed M. Abbas Fehmi*, Philip S. Schoenfeld, James M. Scheiman, Richard S. Kwon, Cyrus R. Piraka, Erik-Jan Wamsteker, Sheryl Korsnes, Michelle A. Anderson, Grace H. Elta Intrathecal Narcotic Infusion Pumps (ITNP) for Intractable Chronic Pancreatitis Pain: A Larger Pilot Series Pradermchai Kongkam*, Stephanie Whitaker, Dennis Wagner, James L. Watkins, Lee McHenry, Evan L. Fogel, Ayman M. Abdel Aziz, Furqaan Ahmed, Stuart Sherman, Glen A. Lehman Moderate and Severe Post ERCP Pancreatitis; Despite Prophylactic Pancreatic Stent Placement Pradermchai Kongkam*, Suzette E. Schmidt, Siriboon Attasaranya, Evan L. Fogel, Lee McHenry, James L. Watkins, Furqaan Ahmed, Stuart Sherman, Glen A. Lehman Good Stents Gone Bad; Endoscopic Treatment of Proximally Migrated Pancreatic Duct Stents Leslie Price*, John J. Brandabur, Richard A. Kozarek A Prospective, Randomized Trial Comparing Two Pancreatic Stents (3F x 6cm vs. 4F x 2cm) for Prophylaxis of Post-ERCP Pancreatitis (PEP) in HighRisk Patients Albert H. Khine, Sandra L. Bernklau, Allan G. Halline, Rama Venu, Russell Brown* Trypsinogen2 Is An Early Diagnostic Marker for Post ERCP Pancreatitis Kenso Kobayashi*, Tamito Sasaki, Yoshifumi Fujimoto, Kenichi Kuwahara, Masahiro Serikawa, Bunjiro Noma, Hiroshi Itsuki, Kazuaki Chayama

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION III: CLINICAL / BILIARY W1635

Management of Preoperatively Suspected Choledocholithiasis: A Decision Analysis Bilal Kharbutli*, Vic Velanovich

Denotes DDW Poster of Distinction

P-315

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL

W E D N E S D A Y MAY 21

W1636

A Novel Hepatico-Jejunostomy Technique Featuring a Purse-String Anastomosis and a Biodegradable Stent: A Preclinical Study in Minipigs. Johanna Laukkarinen*, Juhani Sand, Jenni Leppiniemi, Minna Kellomaki, Isto Nordback

W1649

Image-Guided Sentinel Lymph Node Navigation in Colon Cancer: A Pilot Study Julio M. Mayol*, Rocio Anula, Roberto Delgado-Bolton, Iris Sanchez-Egido, Jose Luis Carreras-Delgado, Jesus A. Fernandez-Represa

W1637

Primary Gallbladder Cancer: A 22 Year Experience in a Tertiary Care Center Rubayat Rahman*, Yevgeniy Ostrinsky, Magesh Sundaram

W1650

W1639

Only Pain from Acute Inflammation Is Relieved One Year Following Laparoscopic Cholecystectomy in Dyspeptic Patients with Cholelithiasis Roger G. Keith, Samaad Malik*, Bruce Reeder, Rajni Chibbar

Low Preoperative Serum Albumin Levels Do Not Affect Early Outcomes After Ileoanal Pouch Surgery But May Be Associated with Long-Term Mortality Kweku A. Appau*, Ravi P. Kiran, Feza H. Remzi, Ian Lavery, Victor W. Fazio

W1651

TGF-Beta1 and IGF-1 and Anastomotic Recurrence of Crohn's Disease After Ileo-Colonic Resection Marco Scarpa, Marina Bortolami, Susan L. Morgan, Andromachi Kotsafti, Cesare Ruffolo, Renata D'Incà, Eugenia Bertin, Lino Polese, Davide F. D'Amico, Giacomo C. Sturniolo, Imerio Angriman*

W1652

Pre- Versus Postoperative Pelvic Radiotherapy in Patients Undergoing Abdominoperineal Resections for Rectal Cancer: Does Timing Make a Difference On LongTerm Patient Quality of Life? Michael S. Kasparek*, Imran Hassan, Robert R. Cima, David W. Larson, Eric J. Dozois, Rachel E. Gullerud, Dirk R. Larson, John H. Pemberton, Bruce G. Wolff

W1653

Sacral Neuromodulation for the Treatment of Fecal Incontinence and Voiding Dysfunction in Female Patients: A Longterm Follow Up Galal S. El-Gazzaz*, Levilester B. Salcedo, Massarat Zutshi, Tracy L. Hull

W1654

Long Term Out Come and Quality of Life After Restorative Proctocolectomy in a Cohort of 955 Canadian Patients Marco Scarpa*, Brenda I. O'Connor, J Charles Victor, Robin S. McLeod

W1655

Colorectal Surgical Specimen Lymph Node Harvest: Improvement of Lymph Node Yield with a Physicians Assistant Robert C. Moesinger*, Christopher L. Hall, Jeffery A. Reese

W1656

Preoperative Versus Postoperative Radiotherapy for Rectal Cancer - Decision Analysis and Outcome Prediction Using a Modified Markov Model Andreas M. Kaiser*, Daniel Klaristenfeld, Robert W. Beart

Relevance of Comorbidity for Postoperative Lethality and Morbidity After Surgery for Perforated Diverticulitis of the Sigmoid Colon Mario H. Mueller*, Mia Karpitschka, Michael S. Kasparek, Martin E. Kreis

W1657

Effect of Metastatic to Examined Lymph Nodes Ratio On Colon Cancer Survival Sukhyung Lee*, Brad Waddell

Management and Treatment of Iliopsoas Abscess Parissa Tabrizian*, Scott Q. Nguyen, Alexander Greenstein, Uma Rajhbeharrysingh, Celia M. Divino

W1658

Comparison of GFAP Expression and Mucosal Mast Cell Numbers in Pediatric Intestinal Diseases Eumenia Castro*, John Ozolek, Kelly A. Miller

W1640

Surgery for Symptomatic Portal Biliopathy Puneet Dhar*, Sudhindran Surendran, Sudheer Othiyil Vayoth, Shaji Ponnambathayil

W1641

Study of a Reverse Phase Polymer in Cholecystectomy: Prevention of Stone Migration and Enhancment of Dissection Marvin Ryou*, Gloria Fernandez-Esparrach, Sohail N. Shaikh, David B. Lautz, Christopher C. Thompson

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION III: CLINICAL / COLON-RECTAL W1642

Laparoscopic and Open Anterior Resection and Low Colorectal Anastomosis for Adult Megacolon: Surgical Outcomes Sergio E. Araujo*, Afonso H. Sousa, Fabio G. Campos, Sergio C. Nahas, Caio S. Nahas, Desiderio R. Kiss, Ivan Cecconello

W1643

To Control Intraoperative Bacterial Contamination and SSI During Anterior Resection or Hartmann'sMile'sOperation; What Can We Do? Katsunori Nishikawa*, Nobuyoshi Hanyuu, Masami Yuda, Hideharu Yasue, Takenori Hayashi, Susumu Kawano, Teruyuki Usuba, Isao Miyoshi, Ryouji Mizuno, Shuuichi Iwabuchi

W1644

W1645

W1646

A Prospective Single Center Experience of “Fast-Track” in Colorectal Surgery: Toward Zero Anastomotic Complications Pierluigi Di Sebastiano*, Nicola Mastrodonato, Giovanni Bisceglia, Beniamino Rucci, Antonio Cafaro, Antonio De Bonis, Angelo Ambrosio, Matteo Scaramuzzi, Vincenzo Crucinio, Fabio Francesco di Mola, Giuseppe Mascetta, Matteo Tardio

W1647

Laparoscopic Versus Conventional Colostomy Closure of Hartmann's Procedure: A Case-Matched Study Jung C. Kang

W1648

A New Method to Analyze the Quality and Progression of Colonoscopy Hans Törnblom, Sanian Akbar, René Tour, Michael Wedén, Urban Sjöqvist, Lena B. Flodqvist, Monica BomanGaliamoutsa, Leif Torkvist, Lars Enochsson*

P-316

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION III: CLINICAL / ESOPHAGEAL W1659

Outcomes of Laparoscopic Assisted Transhiatal Esophagectomy for Adenocarcinoma of Esophagus Martin I. Montenovo*, Kyle J. Chambers, Carlos A. Pellegrini, Brant K. Oelschlager

W1660

The Challenge of Diagnostic Assesment of a Failed Fundoplication: Benefits of High -Resolution Manometry of the GE-Junction Attila Dubecz*, Renato Salvador, Marek Polomsky, Oliver Gellersen, Thomas J. Watson, Jeffrey H. Peters

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—CLINICAL W1661

Looking Beyond Age and Comorbidities As Predictors of Outcomes in Paraesophageal Hernia Repair Anirban Gupta*, David C. Chang, Michael A. Schweitzer, Kimberley E. Steele, Anne O. Lidor

W1662

No Additional Value of Bronchoscopy After EUS in the Preoperative Assessment of Patients with Esophageal Cancer At or Above the Carina Mark van Heijl*, Jikke M. Omloo, Jacques J. Bergman, Mia G. Koolen, Mark I. van Berge Henegouwen, Jan J. van Lanschot

W1663

Analysis of First-Time Antireflux Redo-Surgery Versus Multiple Redo-Surgery Karl H. Fuchs*, Wolfram Breithaupt, Martin Fein

W1664

A Meta-Analysis of Trials Comparing the Effectiveness of Use of Mesh in Laparoscopic Repair of Paraesophageal Hernias Anne O. Lidor*, Debraj Mukherjee, Dorry Segev, David C. Chang, Kimberley E. Steele, Michael A. Schweitzer

W1665

Prediction of Response to Neoadjuvant Therapy in Esophageal Carcinoma By PET-CT Kirsten Thurau*, Matthias Bruewer, Joerg Haier, Christine Franzius, Kai U. Juergens, Norbert Senninger

W1666

Endolumenal Fundoplication with EsophyX™: The Initial North American Experience Simon Bergman*, Cedric S. Lorenzo, Blair A. Jobe, Dean J. Mikami, John G. Hunter, W. S. Melvin

W1667

Analysis of Utilization and Outcome of Laparoscopic and Open Paraesophageal Hiatal Hernia Repair Marcelo W. Hinojosa*, Kevin M. Reavis, Dhavan Parikh, Esteban Varela, Ninh T. Nguyen

W1668

High Prevalence of Lymph Node Metastases in pT1 Esophageal Cancer: Is Local Therapy Justified? Ines Gockel*, Torsten Hansen, Faszillo S. Sultanov, Tran T. Trinh, Mario Domeyer, Ursula Goenner, Theodor Junginger

W1669

The Use of Alveolus Stents in the Treatment of Esophageal Leaks, Perforation or Fistulae Irfan Qureshi*, James D. Luketich, Miguel Alvelo-Rivera, Rodney J. Landreneau, Sebastien Gilbert, Matthew J. Schuchert, Arjun Pennathur

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

W1674

Laparoscopic Treatment of Nonparasitic Hepatic Cysts Orlando J. Torres*, Maria Helena d. Costa, Aline M. Farias, Mauricio M. Matias, Felipe L. Barbosa, Higor C. Aranha, Soraya M. Froes

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION III: CLINICAL / PANCREAS W1675

Human Telomerase Reverse Transcriptase (hTERT) Expression in Carcinogenesis of Serous Cystic Neoplasm of the Pancreas Akira Nakashima*, Yoshiaki Murakami, Kenichiro Uemura, Yasuo Hayashidani, Takeshi Sudo, Yasushi Hashimoto, Hiroki Ohge, Taijiro Sueda, Eiso Hiyama

W1676

Pulmonary Dysfunction Associated with Severe Acute Pancreatitis Hidehiro Sawa*, Yoshifumi Takeyama, Takashi Ueda, Takeo Yasuda, Makoto Shinzeki, Masazou Hayashi, Yonson Ku, Yoshikazu Kuroda

W1677

Incidence and Management of Chylous Leaks Following Pancreatic Resection: A High Volume Single-Center Institutional Experience Lia R. Assumpcao, John L. Cameron, Christopher L. Wolfgang, Edil H. Barish, Kurt Campbell, Michael Choti, Richard D. Schulick, Timothy M. Pawlik*

W1678

Clinical Significance and Natural History of Microinvasive Pancreatic Adenocarcinomas Associated with Resected Intraductal Papillary Mucinous Neoplasms: A Multi-Institutional Experience Eugeen P. Kennedy*, Charles J. Yeo, Patrick B. White, Thomas J. Howard, Patricia K. Sauter, Agnes Witkiewicz, Keith D. Lillemoe, C. Max Schmidt

W1680

Surgical Management of Failed Endoscopic Treatment of Pancreatic Disease Kimberly A. Evans*, Colby W. Clark, Stephen B. Vogel, Kevin E. Behrns

W1681

Is Distal Pancreatectomy (DP) Useful for Treatment of Cancer of the Body or Tail of the Pancreas? Jane S. Wey*, Steven J. Hughes, A. J. Moser, Herbert Zeh, Kenneth K. Lee

W1682

In-Hospital Mortality for Distal Pancreatectomy: A National Study Melissa M. Murphy*, James T. McPhee, Theodore P. McDade, Shimul A. Shah, Giles F. Whalen, Jennifer F. Tseng

SSAT POSTER SESSION III: CLINICAL / HEPATIC W1670

Treatment Strategy for Synchronous Metastases of Colorectal Cancer: Is Hepatic Resection After An Observation Interval Appropriate? Yasuhiro Shimizu*, Tsuyoshi Sano, Kenji Yamao, Yuji Nimura

W1683

Pancreatic Adenocarcinoma with Isolated Local Venous Invasion: Does Surgical Resection Confer a Survival Benefit? Michael Abramson*, Edward W. Swanson, Ioannis Konstantinidis, Edward E. Whang

W1671

Non-Operative Management of High Grade Liver Injuries Beat Schnüriger*, Miranda Schafer, Daniel Inderbitzin, JeanMarc Heinicke, Daniel Candinas

W1684

W1672

Yttrium-90 Microsphere Induced Gastrointestinal Tract Ulceration Christopher D. South*, Marty M. Meyer, Gregory Meis, Edward Y. Kim, Fred B. Thomas, Mark Bloomston

Gemcitabine-Based Adjuvant Chemotherapy Following R1 Resection Still Improves Survival for Patients with Locally-Advanced Pancreatic Cancer Keita Wada*, Hodaka Amano, Fumihiko Miura, Naoyuki Toyota, Kenichiro Kato, Makoto Shibuya, Susumu Kadowaki, Masahiro Yoshida, Ikuo Nagashima, Tadahiro Takada, Takehide Asano

W1685

W1673

Hepatic Neuroendocrine Metastases: Bland or Chemoembolization? Susan C. Pitt*, Jamie Knuth, James M. Kiely, John C. McDermott, Sharon M. Weber, William S. Rilling, Edward J. Quebbeman, David M. Agarwal, Henry A. Pitt

Intra-Operative Application of the Hand-Held Confocal Microscope - a Pilot Study Nam Q. Nguyen*, Rupert W. Leong, Andrew V. Biankin, Elise R. Murr, Peter M. Delaney, Neil Merrett

W1686

Complications Following Pancreaticoduodenectomy Are Common But Do Not Impact Long-Term Survival Mary E. Dillhoff*, Kristian Wall, Peter Muscarella, E. Christopher Ellison, Mark Bloomston

Denotes DDW Poster of Distinction

P-317

W E D N E S D A Y MAY 21

POSTER SESSIONS—CLINICAL

W E D N E S D A Y MAY 21

W1687

A National Survey Regarding the Management of Acute Pancreatitis in Brazil Tercio De Campos*, Jose G. Parreira, Edivaldo M. Utiyama, Samir Rasslan

W1688

The Striking Incidence of Venous Thromboembolism in Hospitalized Patients with Necrotizing Pancreatitis James Lopes*, Nicholas J. Zyromski, Yuriy Zhukov, Attila Nakeeb, Henry A. Pitt, Keith D. Lillemoe, C. Max Schmidt, Thomas J. Howard

W1689

Feasibility of Laparoscopic Partial Pancreatic Head Resection with Lateral Pancreaticojejunostomy (Frey Procedure) for Chronic Pancreatitis Jayleen M. Grams*, Santhi S. Vege, Michael L. Kendrick

W1690

Surgeon's Contribution to Long Term Survival of Pancreatic Cancer Calogero Iacono*, Andrea Ruzzenente, Tommaso Campagnaro, Alessandro Valdegamberi, Chiara Zugni, Maurizio Cantore, Alfredo Guglielmi

SSAT Poster Session 8:00 AM - 5:00 PM

W1701

Gastrojejunal (GJ) Leak After Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) Carries Minimal Risk with An Aggressive Detection / Management Approach, Whereas Greater Morbidity / Mortality Occurs with Leak At the Jejunojejunostomy (JJ) Alexander Perez*, Eric J. DeMaria, Dana D. Portenier, John P. Grant, Aurora D. Pryor

W1702

Quantitative Analysis of Free Ubiquitin and MultiUbiquitin Chain in Precancerous and Cancerous Gastric Tissues Yoshio Ishibashi*, Hideyuki Kashiwagi, Norio Mitsumori, Hiroshi Nimura, Yutaka Suzuki, Nobuo Omura, Katsutoshi Kobayashi, Akira Matsumoto, Koji Takada, Katsuhiko Yanaga

W1703

Surgical Outcomes of Patient with Gastrointestinal Stromal Tumors in the Era of Selective Drug Therapy Mehrdad Nikfarjam*, Serene Shereef, Yixing Jiang, John Liang, Niraj J. Gusani, Eric Kimchi, Mandeep S. Sehmbey, Kevin Staveley-O'Carroll

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION III: CLINICAL / SMALL BOWEL W1691

Enteral Stenting: Management of Complications and Malfunctions in a Single Center Series of 46 Patients Melissa S. Phillips*, Sonia Gosain, Charles M. Friel, Hugo Bonatti, Patrick G. Northup, Michel Kahaleh

W1692

Primary Ileostomy Adenocarcinoma: Rare Condition After Proctocolectomy Rachel Forbes*, Robert Riviello, Alan J. Herline, Roberta L. Muldoon, Paul E. Wise

W1693

Surgical Management of Acute Appendicitis: 50 Years of Progress William Scott Melvin*, Austin Lehr, Joshua Hill, Peter Muscarella, E. Christopher Ellison, Columbus Surgical Society

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION III: CLINICAL / STOMACH W1694

Distal Roux-en-Y Gastric Bypass for the Treatment of Morbid Obesity Jean-Marc Heinicke*, Daniel Inderbitzin, Beat Schnüriger, Daniel Candinas, Bernhard Egger

W1695

Utilization of Pre-Operative Patient Factors to Predict Post-Operative Vitamin D Deficiency for Patients Undergoing Gastric Bypass Judy Jin*, Thomas A. Stellato, Peter T. Hallowell, John Jasper, Scott M. Wilhelm

W1696

Primary Stenting for Malignant Gastric Outlet Obstruction with Self-Expanding Metal Stents (SEMS) in Cape Town, South Africa John M. Shaw*, Eugenio Panieri

W1699

The Molecular and Clinical Significance of CD44 Proteolytic Cleavage in Gastrointestinal Stromal Tumors Kai-Hsi Hsu*, Yan-Shen Shan, Hung-Wen Tsai, Pin-Wen Lin

W1700

Laparoscopic Ajustable Gastric Banding; 4-Year Follow Up Philipp Busch*, Jens Aberle, Helen M. Ameis, Anna Freier, Stephanie Gros, Nina Mommsen, Jakob R. Izbicki, Oliver Mann

P-318

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC BASIC AASLD Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

INFLAMMATION AND IMMUNITY

Sponsored by: Esophageal, Gastric & Duodenal Disorders

W1704



Anti-Apoptotic Effects Against TNF-Alpha Treatment in Bile Duct Ligated Mouse Liver Yosuke Osawa*, Masahito Nagaki, Atsushi Suetsugu, Hisataka Moriwaki

GASTRIC EXOCRINE AND ENDOCRINE SECRETION

W1705

An Immunosuppressive Subtype of Neutrophils Appeared in Advanced Hepatocellular Carcinoma Patients Yasuhiro Tsuda*, Hideo Fukui, Akira Asai, Shinya Fujiwara, Katsuhiko Miyaji, Yasushi Hongo, Akira Fukuda, Toshiaki Hanafusa, Kazuhide Higuchi

W1715

Effect of Carbon Monoxide/Heme Oxygenase On Duodenal HCO3- Secretion in Rats Eitaro Aihara*, Yumi Ohashi, Kento Takahashi, Koji Takeuchi

W1716

Stimulation By Bradykinin of HCO3- Secretion in Rat Gastroduodenal Mucosa Eitaro Aihara*, Yumi Ohashi, Shinichi Kato, Koji Takeuchi

W1717

Phosphodiesterase Isozymes Involved in Regulation of HCO3- Secretion in Isolated Mouse Stomach In Vitro: Interactive Relation to Nitric Oxide (No) and Prostaglandins (PGs) Kazutomo Kita*, Yumi Ohashi, Kento Takahashi, Eitaro Aihara, Koji Takeuchi



W1706



W1707

W1708

W1709

W1710

W1711

W1712

W1713

An Imbalance in Plasma Amino Acids Impairs the Maturation of Bdca1 Positive Circulating Myeloid Dendritic Cells, and Raising the Extracellular Concentration of Valine Improved the Function of Dendritic Cells in Advanced Cirrhotic Patients Eiji Kakazu TLR Induced Innate Immune Responses in NonParenchymal Liver Cells Are Cell Type-Specific Jun Wu, Mengji Lu, Joerg F. Schlaak*

Participants will be able to: • Understand regulation of gastric exocrine and endocrine secretion.

W1718

Phosphatidylinositol 3-Kinase Regulates Translocation of CFTR in Murine Duodenal Epithelial Cells Biguang Tuo*, Guorong Wen, Yalin Zhang, Xuemei Liu, Xue Wang, Xiaoqiang Liu, Hui Dong

W1719

Expression of Toll Like Receptors 3, 4, and 9 in Primary Biliary Cirrhosis and Hepatitis C Petros Benias*, Kavitha Gopal, Yael M. Raymon, Henry C. Bodenheimer, Neil D. Theise

Proton Pump Inhibitor Enhanced Aquaporin-4 Expression with a Reduction of Sonic Hedgehog Expression in Gastric Fundic Parietal Cells Hidekazu Suzuki*, Etsuko Sugai, Yoshimasa Saito, Hitoshi Tsugawa, Masato Yasui, Toshifumi Hibi

W1720

Decreased Expression of Peripheral IL-10 mRNA and Deregulation of Immunoregulatory Function in Patients with Decompensated Cirrhosis Zeid Kayali*, Masahiro Hattori, Alan Escher, Rajiv Sharma, Alice Li, Warren N. Schmidt

Gastric Hypersecretion Related to Cholinergic Hypersensitivity in the Flinders Rat Model of Depression Contributes to Stress Induced Ulceration of the Stomach Ireneusz Padol*, Chang Cheng Wang, Richard H. Hunt

W1721



The Relationship Between Circulating Concentration of Ghrelin, IGF-1, Leptin and the Extent of Atrophic Change of Gastric Mucosa Junichi Kawashima*, Shino Ohno, Tomoya Sakurada, Shoki Ro, Shingo Kato, Susumu Kurosawa, Koji Yakabi

W1722

Control of Parietal and ECL Cells: Known and Unknown Pathways Revealed in a Series of Knockout Mouse Strains Chun-Mei Zhao, Jens F. Rehfeld, Rolf Håkanson, Alan S. Kopin, Duan Chen*

W1723

Protective Effect of Cholinergic Anti-Inflammatory Pathway Against Acute Esophagitis in Rats Jing Zhang, Pengyan Xie*, Hui Li, Xiaowei Shuai, Chi Wang, Jianxiang Liu

W1724

Hydrogen Sulfide Stimulates Hco3- Secretion in Rat Stomach and Duodenum Fumitaka Ise*, Yumi Ohashi, Hironori Takasuka, Eitaro Aihara, Koji Takeuchi

CpG-Containing Immunostimulatory Sequences (Iss) Exhibit Potent Inhibition of HCV Replication in HCV Replicon Line Jason D. Marshall*, Darren S. Heeke, Eduardo Martins, Brian D. Livingston, Gary Van Nest

Dendritic Cells in Patients with Autoimmune Hepatitis Are Resistant to Apoptosis Induced Through TNF Receptor Akihiko Okumura*, Tetsuya Ishikawa, Kazumasa Watanabe, Yumihiko Sasaki, Tetsuya Mizutani, Shin Kunii, Minoru Kubota, Tsuyoki Yama, Kouichi Achiwa, Shinichi Kakumu Peripheral Virus-Specific T-Cell Interleukin-10 Responses Develop Early in Acute Hepatitis C Infection and Become Dominant in Chronic Hepatitis David E. Kaplan*, Fusao Ikeda, Yun Li, Nobuhiro Nakamoto, Sutharsan Ganesan, Diana Lim, Mary E. Valiga, Frederick Nunes, K. Rajender Reddy, Kyong-Mi Chang



Removal of Serum High-Mobility Group Box1 Protects Ischemic-Reperfusion Injury of Rat Livers Tetesu Yamamoto*, Akira Yamanoi, Seiji Yano, Tsuneo Tanaka

W1714

Effect of Mhn-02 On Ischemia-Reperfusion Injury in Rat Liver Jun Hanaoka*, Mitsuo Shimada, Toru Ikegami, Yuji Morine, Satoru Imura

Denotes DDW Poster of Distinction

P-319

W E D N E S D A Y MAY 21

POSTER SESSIONS—BASIC AGA Institute Poster Session 8:00 AM - 5:00 PM

W1736

Gastroprotective Effect of E. coli Nissle (Mutaflor): Evidence from In Vivo and In Vitro Studies Peter Konturek*, Kathrin Löffler, Gregor Burnat, Stanislaw Konturek, Eckhart G. Hahn, Tomasz Brzozowski

W1737

Involvement of Epithelial-Mesenchymal Transition in Recovery of Wound Induced in Gastric Epithelial Cells Shusaku Hayashi*, Nobuaki Takahashi, Aya Yamaguchi, Kohei Yamazaki, Koji Takeuchi

W1738

Gastroprotective Properties of Cobiprostone Against Acid and NSAID-Induced Mucosal Injury in Porcine Gastric Mucosa Meghali P. Nighot*, Ryuji Ueno, Birgit Roerig, Kathleen A. Ryan, Anthony T. Blikslager, Adam J. Moeser

W1739

Isoflavones in Soy-Germ Pasta Modulate the Expression of Human Gastric Genes Involved in Mucosal Defense Stefania Asciutti*, Elisabetta Antonelli, Kenneth D. Setchell, Myriam Alcalay, Danilo Castellani, Elisabetta Nardi, Vittorio Giuliano, Simona Corsi, Olivia Morelli, Monia Baldoni, Antonio Morelli, Carlo Clerici

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

MUCOSAL DEFENSE: PRE-EPITHELIAL, EPITHELIAL, AND POST-EPITHELIAL Participants will be able to: • Understand in more detail mechanisms that regulate mucosal defense.

W E D N E S D A Y

W1725



Importance of Epi-Lipoxin A4 and Nitric Oxide (No) in the Mechanism of Adaptation of Gastric Mucosa to Continuous Aspirin Administration Robert Pajdo, Tomasz Brzozowski*, Peter C. Konturek, Zbigniew Sliwowski, Grzegorz Burnat, Aneta Targosz, Stanislaw J. Konturek, Wieslaw W. Pawlik

W1726

Lansoprazole, a Proton Pump Inhibitor, Mediated AntiInflammatory Effect in Gastric Mucosal Cells Through the Induction of Heme Oxygenase-1 Via the Activation of NRF2 and the Oxidation of Keap1 Tomohisa Takagi*, Yuji Naito, Hirokazu Kajikawa, Hitomi Okada, Yayoi Nukigi, Katsura Mizushima, Kazuhiko Uchiyama, Takahiro Suzuki, Ikuhiro Hirata, Satoko Adachi, Satomi Akagiri, Osamu Handa, Satoshi Kokura, Hiroshi Ichikawa, Toshikazu Yoshikawa, Hirofumi Matsui



MAY 21 W1727

Expression of DCAMKL1 in Putative Stem Cells Juxtaposed to Isthmal Parietal Cells in the Stomach Miho Adachi*, Hiroshi Nagata, Norihito Watanabe, Toshifumi Hibi

W1728

Lubiprostone Stimulates CFTR-Dependent Duodenal Bicarbonate Secretion in Rats Misa Mizumori*, Yasutada Akiba, Jonathan D. Kaunitz

W1729

Brush Border Intestinal Alkaline Phosphatase Inversely Regulates Luminal ATP Signaling Via P2y Receptor in Rat Duodenum Misa Mizumori*, Yasutada Akiba, Paul H. Guth, Jonathan D. Kaunitz

W1730

Acid pH Primes the Innate Epithelial Response to LPS in the Esophageal Epithelium Mei-Lun Wang*, Carmen Z. Michaylira, Anil K. Rustgi, Tanesha D. Cash-Mason

W1731

Effects of Heat- and Cold-Sensitive Trp Channel Agonists On Tight Junction Barrier in Primary Cultured Rat Gastric Epithelial Cells Shogo Sato*, Kimihito Tashima, Kenjiro Matsumoto, Syunji Horie

W1732

Rebamipide, a Cytoprotective Drug, Increases Gastric Mucus Secretion in Human - Evaluations with the Endoscopic Gastrin Test Katsunori Iijima*, Kazuhiko Ishihara, Masaaki Ogawa, Tomoyuki Koike, Shuichi Ohara, Tooru Shimosegawa

W1733

Oral Bacteria Regulate Gastric Mucus Thickness Via Bioactivation of Dietary Nitrate Joel Petersson*, Olof Schreiber, Mia Phillipson, Jon Lundberg, Lena P. Holm

W1734

A New Role of Alpha 1-Antitrypsin/Alpha-1 Peptidase Inhibitor (A1-PI) in Gastroduodenal Diseases Thomas Wex*, Doerthe Kuester, Gerhard Treiber, Anja Krieg, Michael Vieth, Albert Roessner, Peter Malfertheiner

W1735

Sulforaphane Stimulates Histamine-Mediated Gastric Acid Secretion and Ameliorates MonochloramineInduced Gastric Mucosal Injury Akinori Yanaka, Tatsunori Akaogi*

P-320

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Growth, Development & Aging

STEM CELLS, GROWTH AND DEVELOPMENT IN THE GI TRACT Participants will be able to: • Evaluate the growth and development of stem cells in the GI tract. W1740

Loss-of-Function Variants of the Epithelial Barrier Protein Filaggrin Predispose to Marked Atopic CoMorbidity in Paediatric Inflammatory Bowel Disease Johan Van Limbergen*, Richard K. Russell, Elaine Nimmo, Yiwei Zhao, Haihui Liao, Hazel E. Drummond, Linda Smith, Niall H. Anderson, Gail Davies, Peter M. Gillett, Paraic McGrogan, Lawrence Weaver, Michael W. Bisset, Gamal Mahdi, David C. Wilson, Irwin McLean, Jack Satsangi

W1741

Activation of NFAT Increases PTEN Expression in Human Intestinal Cells Yuning Zhou, Qingding Wang*, Lindsey N. Jackson, ChiWing Chow, B. M. Evers

W1742



Guidance of Vagal Sensory Axons in the Fetal Gut: Long-Range Netrin-Mediated Attraction Terminated By Laminin in the Target Microenvironment Elyanne Ratcliffe*, Fabien D'Autreaux, Michael D. Gershon

W1743

Postnatal Maturation of Neuromuscular Transmission in the Guinea Pig Ileum Xiaochun Bian*, Bhavik A. Patel, James Galligan, Greg M. Swain

W1744

Developmental Changes in CCK-Induced Ca2+Dependent and Ca2+-Independent Contractility in Gallbladder Smooth Muscle Cristina Camello-Almaraz, Beatriz Macias, Soledad Alcon, Pedro J. Gomez-Pinilla, Pedro Camello, Maria J. Pozo*

W1745

Influence of Bacterial Colonisation On Glycosylation of Intestinal Mucin Oligosaccharides During Early Development Rebecca E. Forder*, Catherine Robbe-Masselot, Gordon S. Howarth, Robert J. Hughes

W1746

Embryonic Stem Cell Chimeric Mice Reveal Clonal Development of Pancreatic Acini, But Not Islets E. S. Swenson*, Timothy P. Nottoli, James McGrath, Neil D. Theise, Diane Krause

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC W1747

W1748

W1749

Human Small Intestinal Crypts Are Clonal, Contain Multiple Stem Cells and Mutated Crypts Divide By Fission Lydia Gutierrez, Maesha G. Deheragoda, Sean Preston, Janusz A. Jankowski, Nicholas A. Wright, Stuart A. McDonald* Esophageal Stem Cells Have the Capacity for SelfRenewal and Lineage Specification Jiri Kalabis*, Kenji Oyama, Takaomi Okawa, Hiroshi Nakagawa, Jose Figueiredo, Umar Mahmood, Carmen Z. Michaylira, Doug Stairs, Wafik S. El-Deiry, Meenhard Herlyn, Anil K. Rustgi Altered Gastric Cell Lineage Differentiation and Emergence of Spasmolytic Polypeptide Expressing Metaplasia (SPEM) After Acute Oxyntic Atrophy in Histidine Decarboxylase Deficient (HDC-Ko) Mice Koji Nozaki*, Shigeo Takaishi, Timothy C. Wang, James R. Goldenring

AGA Institute Poster Session 8:00 AM - 5:00 PM

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

HORMONES & RECEPTORS: RECEPTOR SIGNALING Participants will be able to: • Learn about recent research in receptor signaling. W1756



Association of Soluble Guanylyl Cyclase with 90-Kda Heat Shock Protein (Hsp90) Regulates sGC Expression and Activity and Nitric Oxide-Mediated Smooth Muscle Relaxation Karnam S. Murthy*, Sunila Mahavadi

W1758



Selectivity and Potency of Putative Neuromedin B Receptor (Nmbr) Antagonists for Human Bombesin Receptors (Bnr) Nieves Gonzalez*, Samuel A. Mantey, Tapas K. Pradhan, Veronica Sancho, Terry W. Moody, David H. Coy, Robert T. Jensen

W1759

Rapid Activation of Protein Kinase D in Response to Wounding of IEC-18 and IEC-6 Monolayers James Sinnett-Smith*, Steven H. Young, Enrique Rozengurt

Sails Pavilion San Diego Convention Center

Sponsored by: Hormones, Transmitters, Growth Factors, & Their Receptors

Sails Pavilion San Diego Convention Center

HORMONES & RECEPTORS: GENE EXPRESSION

W1760

Participants will be able to: • Learn about pepitde and receptor: gene expression in different cell types.

Rapid FAK Phosphorylation On Ser-910 and Ser-843 in Intestinal Epithelial Cells Xiaohua Jiang, James Sinnett-Smith*, Enrique Rozengurt

W1761

PKD Regulates the Synergistic Expression of COX-2 By Bradykinin and TNF-α in Colonic Myofibroblasts James Yoo*, Christine Chung, Lee W. Slice, James SinnettSmith, Enrique Rozengurt

W1762

Basal Prostaglandin Levels Are Required for Pyk2 Expression and Ang II-Dependent MAPK Phosphorylation in Intestinal Epithelial Cells H. Pham, Steven S. Wu, Romina Vincenti, Enrique Rozengurt, Lee W. Slice*

W1763

New Critical Residues in the Predicted Intracellular Loop Domains of the Human Motilin Receptor Bunzo Matsuura*, Teruhisa Ueda, Maoqing Dong, Laurence J. Miller, Teruki Miyake, Shinya Furukawa, Morikazu Onji

W1764



Relevance of Functional Promoter Variant for the Regulation of the Extrahepatic UDPGlucuronosyltransferase Ugt1a7 By the Hepatocyte Nuclear Factors Hnf1alpha and Hnf4 Alpha Ursula Ehmer*, Thomas J. Erichsen, Tim O. Lankisch, Sandra Kalthoff, Nicole Freiberg, Michael P. Manns, Christian P. Strassburg

W1750

Binding of HuR to Au-Rich Elements Within Rgs4 3'Untranslated Region Is a Critical Determinant of Rgs4 mRNA Stability in Smooth Muscle Cells Wenhui Hu*, Fang Li, Sunila Mahavadi, Karnam S. Murthy

W1751



Effects of Alosetron On CGRP Release from Colonic Tissue in Rats James A. McRoberts*, Helena S. Ennes, Vanessa Z. Ameen, Gareth J. Sanger, Emeran A. Mayer

W1752

Efficient Disruption of the Hif1-Phd Feedback Loop By the Central Reactive Oxygen Species Hydrogen Peroxide (H2O2) Gunda Millonig*, Hongnian Guo, Helmut Karl Seitz, Sebastian Mueller



W1753



Substance P Decreases Insulin-Induced Glucose Uptake in Adipocytes Iordanis Karagiannidis*, Kyriaki Bakirtzi, Thomas Thomou, Collin Bowe, Kara Gross, Tamara Pirtskhalava, Nino Giorgadze, James Kirkland, Charalabos Pothoulakis

W1754

Expression of 5-HT4 Receptor Splice Variants By DRG Neurons Helena S. Ennes*, Emeran A. Mayer, Gareth A. Hicks, Hans-Juergen Pfannkuche, James A. McRoberts

W1765



Protein Kinase C Mediates Feedback Inhibition of ERK Through EGFR Transactivation in Intestinal Epithelial Cells Steven S. Wu*, Sheung K. Vong, Enrique Rozengurt

W1755

Blockade of Insulin-Like Growth Factor-I Receptor Is a Useful Anticancer Therapeutic for Esophageal Squamous Cell Carcinoma Hiroyuki Yamamoto*, Yasushi Adachi, Nobuki Miyamoto, Chie Miyamoto, Katsuhiko Nosho, Hiroaki Taniguchi, Tadateru Maehata, Kentaro Yamashita, Yoshiaki Arimura, Fumio Itoh, Kohzoh Imai, Yasuhisa Shinomura

W1766

Identification of Peptide-Ligand Binding Domains of the Growth Hormone Secretagogue Receptor Teruhisa Ueda*, Bunzo Matsuura, Teruki Miyake, Shinya Furukawa, Yoichi Hiasa, Hidehiro Murakami, Morikazu Onji



Denotes DDW Poster of Distinction

P-321

W E D N E S D A Y MAY 21

POSTER SESSIONS—BASIC W1778

Small Intestinal Bacterial Overgrowth (SIBO) Can Affect Intestinal Permeability Alessia Cazzato*, Cristiano Lauritano, Emidio Scarpellini, Giovanni Gigante, Matteo Gargovich, Giovanni Cammarota, Antonino De Lorenzo, Giovanni Gasbarrini, Antonio Gasbarrini

W1779

Vsl#3 for Chronic Pouchitis; Experience in UK Clinical Practice Simon D. McLaughlin*, Matthew W. Johnson, Sue K. Clark, Paris P. Tekkis, Paul J. Ciclitira, Ralph. J. Nicholls

Small Intestinal Bacterial Overgrowth (SIBO) in Patients with Duodenogastric (DGR) Post-Cholecystectomy Alessia Cazzato*, Cristiano Lauritano, Lucia Sparano, Giovanna Vitale, Davide Roccarina, Giovanni Cammarota, Antonino De Lorenzo, Giovanni Gasbarrini, Antonio Gasbarrini

W1780

Oxalobacter Formigenes and the Risk of Calcium Oxalate Renal Calculi: An Endogenous Probiotic? David R. Cave*, Judith P. Kelly, Gary C. Curhan, Theresa E. Anderson, Stephen P. Dretler, Glenn M. Preminger, David W. Kaufman

Ciprofloxacin in Rabbits Infected with a Shiga-Toxin (Stx)-Producing E. coli (Stec) Srain Leads to Worse Clinical Outcome and Increased Toxin Release Antonio Serna*, Chengru Zhu, Amelia J. Nugent, Erin K. Okeefe, Edgar Boedeker

W1781

Pretreatment But Not Treatment with Probiotics Abolishes Mouse Intestinal Barrier Dysfunction in Acute Pancreatitis Jakub Rychter*, Paul L. van Minnen, Andre Verheem, Harro M. Timmerman, Ger T. Rijkers, Marguerite Schipper, Hein G. Gooszen, Louis M. Akkermans, Alfons B. Kroese

The Pathogenesis of Renal Disease Due to Enterohemorrhagic E. coli in Germ Free Mice Kathryn A. Eaton*, David I. Friedman, Gayle J. Francis, Vincent B. Young, Jennifer Haeger, Thomas S. Whittam, Jessica S. Tyler, Galeb Abu-Ali

W1782

Helicobacter Hepaticus Urease Is Not Required for Intestinal Colonization But Promotes Hepatic Inflammation in Male a/Jcr Mice Zhongming Ge*, Amy Lee, Mark T. Whary, Arlin B. Rogers, Kirk J. Maurer, Nancy S. Taylor, David B. Schauer, James G. Fox

W1783

Effect of Combined Antifungeal and Probiotic Therapy On Candida Colonization of Human Ulcerative Colitis and the Healing of Colonic Injury in Experimental Animal Model of Colitis Ulcerosa Malgorzata Wcislo-Zwolinska*, Tomasz Brzozowski, Peter C. Konturek, Danuta Drozdowicz, Aneta Targosz, Jerzy Stachura, Tomasz Mach, Stanislaw Konturek, Wieslaw W. Pawlik

W1784

Prenatal Exposure to Bacterial Toxin Reduces Gut Sensitivity to Necrotising Enterocolitis in Preterm Neonates Malene S. Cilieborg, Nicolai Weber, Mette Schmidt, Per T. Sangild*

W1785

Enteropathogenic E. coli Non-Lee Encoded Effectors Nleh1/2 Fail to Suppress Inflammatory Response, in Contrast to Shigella Homolog Ospg Sandhya V. Royan*, Amy Kim, Beth McCormick, Colleen Middleton, Lila Gollogly, V. K. Viswanathan, Gail Hecht

W1786

A Novel Experimental Mouse Model of Clostridium difficile Associated Disease Kianoosh Katchar, Xinhua Chen*, N. Nanda Nanthakumar, Jeffrey D. Goldsmith, Ciaran P. Kelly

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Intestinal Disorders

LUMINAL MICROBIOTA IN INTESTINAL HEALTH AND DISEASE Participants will be able to: • Review research in intestinal health and disease. W1767

W E D N E S D A Y

W1768

W1769

MAY 21 W1770

Reduction of Gut-Caused Halitosis with Probiotic E. coli Nissle 1917 - First Findings Simon Straub*, Katrin Andraczek, Corinna Wolff, Jobst Henker

W1771

Effect of Eight Weeks of Treatment with Probiotic Yoghurt On Irritable Bowel Syndrome Symptoms - a Randomized, Double-Blind, Placebo-Controlled Trial Bo Sondergaard*, Rickard W. Ekesbo, Johan Olsson, Kajsa Ohlson, Ulla K. Svensson, Peter Bytzer

W1772

Use of Vsl#3® (a New High Concentration Probiotic Mixture) in the Treatment of Childhood Diarrhea with Specific Reference to Rotavirus Diarrhea Anand P. Dubey*, Rajeshwari Krishnan, Anita Chakravarti, Arun Aggarwal, Brij K. Atal, Claudio De Simone, Vandana Pandey, Aditya R. Sahu

W1773

A Randomized Trial Evaluating Probiotic Preparation Vsl#3 Versus Oral mesalamine in Patients with Active Microscopic Colitis Sarika Rohatgi, Vineet Ahuja*, Govind K. Makharia, Claudio De Simone, Aditya R. Sahu

W1774

Bifidobacterium Bifidum Improves Intestinal Barrier Function in Experimental Necrotizing Enterocolitis Ludmila Khailova, Andrew Maynard, Katerina Dvorak, Kelly M. Arganbright, Melissa Halpern, Toshi Kinouchi, Masako Yajima, Bohuslav Dvorak*

W1775



Enteropathogenic Escherichia coli Inhibits Vitamin B1 (Thiamin) Transport in Human Intestinal Epithelial Cells Ashokkumar Balasubramaniem*, Hamid M. Said

W1776

Dam Methylation Is Essential in Vibrio Vulnificus and Influences Its Interactions with Host Cells Jason H. Kehrl, Kavankumar B. Patel, Lyn Sue Kahng*

W1777

Excess Seqa Causes a DNA Replication Arrest in Vibrio Cholerae, and Heterologous Overexpression Experiments Show That Lethality Is Specific to V. Cholerae Djenann Saint-Dic, Jason H. Kehrl, Brian P. Frushour, Lyn Sue Kahng*

P-322

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Neurogastroenterology and Motility

NERD, GERD, AND OTHER ESOPHAGEAL AND OROPHARYNGEAL DISORDERS Participants will be able to: • Learn about signaling mechanisms controlling oropharyngeal and esophageal motility. W1787

Cholinergic Induced Relaxation of the Gastric Clasp Fibers May Mediate TLESR in Humans Anil K. Vegesna*, Alan S. Braverman, Ramashesai Besetty, Michael R. Ruggieri, Larry S. Miller

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC W1788

The Novel GABAB Receptor Agonist Azd3355 Inhibits Acid Reflux and Reduces Esophageal Acid Exposure As Measured By 24h Phmetry in Dogs Lena Brändén, Anita Carlsson, Jörgen Jensen, Anders Lehmann*

W1789

The New Reflux Inhibitor Azd3355 Has a Low Propensity for Inducing Central Side Effects Due to Its Affinity for the GABA Carrier Anders Lehmann*, L. Ashley Blackshaw, Thomas Elebring, Jörgen Jensen, Jan P. Mattsson, Karolina A. Nilsson, Pirjo Saransaari, Sverker von Unge

W1790



Body Mass Index Is Associated Through Common Genetic Pathways with Symptomatic Gastro-Esophageal Reflux Disease (GERD): A U.S. Co-Twin Study Mike Jones, Anthony Lembo, Nicholas J. Talley*

W1791

Prevalence of Dyspepsia Symptoms in Patients with Non Erosive Reflux Disease (NERD) Subclassified Using 24Hour Ambulatory Intraluminal pH-Impedance Edoardo Savarino*, Daniel Pohl, Luca Sconfienza, Patrizia Zentilin, Pietro Dulbecco, Radu Tutuian, Vincenzo Savarino

W1792

W1801

Does Gas Reflux Provoke Any Symptoms of GERD? Clinical Significance of Gas Reflux in Patients with GERD By Multichannel Intraluminal Impedance and pH Study Kyu Sung Chung*, Joon Seong Lee, Hee Hyuk Im, Yun Jung, Tae Hee Lee, Won Young Cho, Soo Hoon Eun, Bong Min Ko, Su Jin Hong, Jin-Oh Kim, Joo Young Cho, Moon Sung Lee, Chan Sup Shim, Boo Sung Kim

W1802

General and Disease Specific Quality of Life in Long Lasting Achalasia I. Leeuwenburgh, Joyce Alderliesten*, E. J. Kuipers

W1803

High Resolution Manometry with Large Volume Multiple Repeated Swallows AIDS the Detection of Oesophageal Pathology Rami Sweis*, Roy Anggiansah, Terry Wong, Angela Anggiansah, Mark R. Fox

W1804

The Safety of Pneumatic Balloon Dilatation in Achalasia Patients: Results from a Large Cohort Study J. Alderliesten*, J. M. Conchillo, E. J. Kuipers

W1805

Correlative Nervous Pathway of Effects On Frequency of Transient Lower Esophageal Sphincter Relaxation Via Electroacupuncture At Pc6 in Cats Defeng Zhou, Jing Zhang, Xiaowei Shuai, Chi Wang, Pengyan Xie*

The Role of Gastro-Esophageal Pressure Gradient On Esophageal Peristalsis in GERD Patients Fernando Fornari*, Carlos Augusto S. Madalosso, Richard R. Gurski

W1793

Identification of Impaired Bolus Transit and Clearance By Secondary Peristalsis in Patients with NonObstructive Dysphagia Chien-Lin Chen*, Michal M. Szczesniak, Taher Omari, Ian J. Cook

W1794

Patients with Primary (Idiopathic) Achalasia Have Circulating Peripheral Blood Mononuclear Immune Cells That Are Hyper- Reactive to the Herpes- Simplex -1 Virus Kar W. Lau*, Conall McCaughey, Peter V. Coyle, Liam J. Murray, Brian T. Johnston

W1795

Peristaltic Transition Zone Defects and Dysphagia: Real, But Few and Far Between Sudip K. Ghosh*, John E. Pandolfino, Monika A. Kwiatek, Peter J. Kahrilas

W1796

Solid-State High Resolution Manometry (HRM) of the Upper Esophageal Sphincter (UES) with Pressure Topographic Analysis Identifies Sphincter Dysfunction Confirmed with Fluoroscopy Sudip K. Ghosh*, John E. Pandolfino, Peter J. Kahrilas

W1797

Exaggerated LES Rebound Contractions Following Amyl Nitrite in Achalasia Patients: Is This Inhibitory Denervation Hypersensitivity? Lilani P. Perera*, Candy Hofmann, Linda Tatro, Walter J. Hogan, Benson T. Massey

W1798

Features of TLESR and Associated Reflux Depend On the Terminating Motor Event Shiko Kuribayashi*, Benson T. Massey, Lilani P. Perera, Linda Tatro, Candy Hofmann, Muhammad Hafeezullah, Syed Q. Hussaini, Adeyemi Lawal, Reza Shaker

W1799

Distension of the Esophago-Gastric Junction Augments Meal-Induced Triggering of TLESR Michiel P. van Wijk*, Geoff Davidson, Marc A. Benninga, Taher Omari

W1800

Utilizing Intraluminal Pressure Gradients to Predict Esophageal Clearance: A Validation Study John E. Pandolfino*, Nilesh Lodhia, Sudip K. Ghosh, Peter J. Kahrilas

W1806

The Frequency of Functional Heartburn (Fh) and Other Gastroesophageal Reflux (GER)-Related Symptoms in Subjects with IBS in the Community Is Higher Than That of the Controls, and More Likely Among Those with An Abnormal Body Mass Index (BMI) Max J. Schmulson*, Daniela Pulido

W1807

Quantifying the Magnitude and Variability of Esophageal Sensitisation Which Develops Following Human Experimental Esophageal Acidification Yang C. Chua*, Anthony R. Hobson, Abhishek Sharma, Robert P. Willert, Charles H. Knowles, Qasim Aziz

W1808

Swallowing Differences Between Men and Women Roberto O. Dantas*, Rachel A. Cassiani, Carla M. Santos, Leda M. Alves, Geruza C. Gonzaga, Suleimy C. Mazin

W1809

Effect of Carbonated Drinks On Upper Digestive Tract Sensations and Physiology in Healthy Subjects Maria Flavia Savarese*, Giovanni Sarnelli, Giovanna Vollono, Alba Rocco, Pietro Coccoli, Carla Cirillo, Maxime E. Buyckx, Rosario Cuomo

W1810

The Use of Multichannel Intraluminal Impedance (MII) in the Assessment of Post-Fundoplication Swallowing Disorders in Children Sujit M. Philipose, Beth Skaggs, John Hayes, Frederick W. Woodley, Hayat M. Mousa*

W1811

Distinct Clinical and Epidemiological Features Separate GERD Patients with Physiological Esophageal Acid Exposure from Patients with Pathological Acid Exposure Durk Vries, de*, Margot A. van Herwaarden, André Smout, Melvin Samsom

W1812

Laryngopharyngeal Reflux As the Presenting Symptom of Gastroparesis Issac Galandauer*, Shireen A. Pais, Leslie M. Riopel, Craig Zalvan, Brad M. Dworkin

W1813

Opiate-Induced Esophageal Dysmotility Robert Kraichely*, Amindra S. Arora, Joseph a. Murray

W1814

The Effect of Johrei (Energy Healing) Versus Wait-List On Symptoms of Patients with Functional Chest Pain (Fcp) of Presumed Esophageal Origin - a Randomized Trial Tomas Navarro-Rodriguez*, Anita Gasiorowska, Yukihiro Ibuki, Ram Dickman, Bridget Moty, Jeannette Powers, Hemanth Gavini, Ronnie Fass

Denotes DDW Poster of Distinction

P-323

W E D N E S D A Y MAY 21

POSTER SESSIONS—BASIC

W E D N E S D A Y MAY 21

W1815

Diurnal Patterns of Esophageal Acid Exposure in Male and Female Patients with Reflux Symptoms Angela G. Bradley*, Hack J. Kim, John K. DiBaise, David E. Fleischer, Virender K. Sharma, Michael D. Crowell

W1816

Esophageal Hypersensitivity and Autonomic Nervous System Function in Patients with NERD and RE Yanli Zhang*, Zhifeng Wang, Xiucai Fang, Meiyun Ke

W1817

The Preterm Piglet - a Potential Model for the Preterm Infant in the Study of Esophageal Maturation Soeren1 Rasch, Per T. Sangild, Hanne K. Moeller, Hans Gregersen, Mette Schmidt, Chantal Lau*

AGA Institute Poster Session 8:00 AM - 5:00 PM

W1824

Dietary Protein and Amino Acids Regulate the Synthesis of Pancreatic Digestive Enzymes Maria Dolors Sans*, Stephen J. Crozier, Nancy L. Vogel, John A. Williams

W1825

Effect of Combination of Curcumin and Rosiglitazone On Experimental Acute Pancreatitis Pratibha Khosla, Promila Pandhi, Samir Malhotra, Ritambhara Nada, Surinder Rana, Deepak K. Bhasin*

W1826

The Effect of Rosiglitasone, a Specific PPAR -Gamma Ligand, On the Development of Experimental Sodium Taurocholate Induced Acute Pancreatitis and the Role of Immunohistochemical Reaction Krzysztof Celinski*, Beata Prozorow-Krol, Agnieszka Korolczuk, Grazyna Czechowska, Maria Slomka, Elzbieta Korobowicz, Halina Cichoz-Lach, Agnieszka Madro

Sails Pavilion San Diego Convention Center

Sponsored by: Nutrition & Obesity

SSAT Poster Session 8:00 AM - 5:00 PM

VITAMINS, MINERALS, MICRONUTRIENTS, HERBAL AND ALTERNATIVE THERAPIES

SSAT POSTER SESSION III: BASIC / COLON-RECTAL

Participants will be able to: • Evaluate recent research in vitamins, minerals, micronutrients, and herbal therapies. W1818

W1819

W1820

Chromium Supplementation Decreases Insulin Resistance and Trunk Fat Ellie Aghdassi, Irving E. Salit, Saira Mohammed, Bianca M. Arendt, Johane P. Allard* Lemon Grass (Cymbopogon Citratus) Ameliorates Murine Spontaneous Ileitis By Decreasing T Lymphocytes Migration to Inflamed Intestinal Microvessels Chikako Watanabe*, Ryota Hokari, Mitsuyasu Nakamura, Shunsuke Komoto, Yoshikiyo Okada, Chie Kurihara, Michiko Miyagi, Hirokazu Yokoyama, Toshifumi Hibi, Soichiro Miura Green Tea Polyphenols Against Colitis in Mouse Models Helieh S. Oz*, Jeffrey L. Ebersole, Willem J. de Villiers

AGA Institute Poster Session 8:00 AM - 5:00 PM

W1827

Fluorophore-Conjugated Anti-CEA Antibody for Intraoperative Imaging of Pancreatic and Colorectal Cancer Michele McElroy*, Sharmeela Kaushal, George A. Luiken, Robert M. Hoffman, Michael Bouvet

W1828

Murine Colitis Is Inhibited in MMP-9 Knockout Mice: The Addition of IGFBP-3 Overexpression Does Not Further Decrease Disease Severity Raymond Baxter*, Aviad Hoffman, Ik-Yong Kim, Abu Nasar, Kumara H. Shantha, Mark Foster, Keith Hoffman, Richard L. Whelan

W1829

Everolimus Impairs the Healing of Intestinal Anastomoses Markus A. Kueper*, Stefan Beckert, Petra Mayer, Jorg Glatzle, Juergen Weinreich, Alfred Königsrainer, Stephan Coerper

W1830

Polyphenon E, An EGCG Containing Green Tea Extract That Inhibits Tumor Growth, Has No Impact On Wound Collagen Content or Clinical Rate of Wound Infection or Dehiscence Yet Has a Mild Inhibitory Effect On Healing As Judged By Tensometry Aviad Hoffman*, Raymond Baxter, Abu Nasar, Thomas R. Gardner, Kumara H. Shantha, Keith Hoffman, Richard L. Whelan

Sails Pavilion San Diego Convention Center

Sponsored by: Pancreatic Disorders

PANCREATIC PHYSIOLOGY AND PATHOBIOLOGY II Participants will be able to: • Understand the physiology and pathophysiology of the pancreas. W1821

W1822

W1823

P-324

Protein Kinase D Mediates Nf-κB Activation Induced By Cholecystokinin and Cholinergic Signaling in Pancreatic Acinar Cells Jingzhen Yuan*, Aurelia Lugea, Ling Zheng, Ilya Gukovsky, Mouad Edderkaoui, Stephen J. Pandol

Sails Pavilion San Diego Convention Center

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION III: BASIC / ESOPHAGEAL W1831

Gdnf-Mediated Increase in β-Cell Mass and Resistance to STZ-Induced Hyperglycemia Is Associated with Increased Cell Proliferation, and Pdx1 and Sox9 Expression Simon Mwangi*, Shreya M. Raja, Kavya Sebastian, Shanthi Srinivasan

Polymorphism Arg290Arg in Esophageal Cancer Related Gene 1 (ECRG1) Is a Prognostic Factor for Survival in Esophageal Cancer Kai Bachmann*, Jussuf T. Kaifi, Paulus G. Schurr, Jakob R. Izbicki, Tim Strate

W1832

SRC Signaling Pathways Recruit Cell-Cell Adhesion and Microtubular-Microfilamentous Systems in Cholecystokinin-Stimulated Pancreatic Acini Fumihiko Nozu*, Michio Imawari

Barrett's Intestinal Metaplasia mRNA Expression Profile in Formalin-Fixed, Paraffin-Embedded Endoscopic Biopsy Specimens Fiona I. Schneiders, Natalia K. Botelho, Reginald V. N. Lord*

W1833

KI-67 Antigen Is Overexpressed in Barrett's Carcinogenesis Bernardo Volkweis, Richard R. Gurski*, Luise Meurer, Maria Isabel A. Edelweiss, Gustavo Morellato, Marcelo k. Schmidt

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—BASIC SSAT Poster Session 8:00 AM - 5:00 PM

W1844

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION III: BASIC / HEPATIC W1834

W1835

Enteral Immunonutrition with Long Chain Triglycerides Significantly Reduces the Recruitment of Immune Cells Into the Liver During Experimental Sepsis Maximilian Feilitzsch*, Theo Maier, Judith Junginger, Tobias Meile, Markus A. Kueper, Alfred Koenigsrainer, Jorg Glatzle Association of Non-Alcoholic Steatohepatitis (NASH) and Inflammatory Mediators from Adipose Tissue Atul K. Madan*, David S. Tichansky, John Fain

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Electrosurgical and Ultrasonic Devices: An Evaluation of Thermal Spread and Other Device Characteristics Charles J. Dolce*, Jennifer E. Keller, Kenneth C. Walters, Jessica Heath, Amy E. Lincourt, James Norton, B. Todd Heniford, David A. Iannitti

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION III: BASIC / STOMACH W1845

Epithelial Cell Turnover Is Increased in the Excluded Stomach Mucosa After Vertical Banded Roux-en-Y Gastric Bypass for Morbid Obesity Adriana V. Safatle-Ribeiro*, Pedro A. Petersen, Ulysses Ribeiro, Bruna S. Quevedo, Thaise Y. Tomokane, Rogério Kuga, Joel Faintuch, Paulo Sakai, Arthur B. Garrido, Carlos E. Corbett, Ivan Cecconello

SSAT POSTER SESSION III: BASIC / PANCREAS W1836

Reduction of Local Inflammatory Response On Acute Pancreatitis in Rats: Effects of a Hypertonic Saline Solution Ana Maria M. Coelho*, Jose Jukemura, Sandra N. Sampietre, Nilza T. Molan, Lourenilson J. Souza, Rosely A. Patzina, José Eduardo M. Cunha, Marcel C C. Machado

W1837

Effects of Late Administration of Pentoxifylline in Experimental Severe Acute Pancreatitis Tiago A. Kunitake, José Jukemura*, Ana Maria M. Coelho, Marcel C. Machado, José Eduardo M. Cunha

W1838

Development of Monoclonal Antibodies to Aid in the Diagnosis of Pancreatic Cancer Karin M. Hardiman*, Craig S. Dorrell, Christopher Corless, Brett C. Sheppard, Markus Grompe, Philip R. Streeter

W1839

Combination Therapy with Suberoyl Bis-Hydroxamic Acid (SBHA) and Lithium Chloride for Gastrointestinal Carcinoid Tumors Joel T. Adler*, Daniel G. Hottinger, Muthusamy Kunnimalaiyaan, Herbert Chen

W1840

Epithelial to Mesenchymal Transition in Pancreatic Cancer: Expression and Role of the Transcription Factors Snail, Slug, and Twist Hubert G. Hotz*, Birgit Hotz, Heinz J. Buhr

W1841

A Model for Defining Molecular Aspects of Pancreatic Ductal Adenocarcinoma Patients for Targeted Adjuvant Therapy Shayna L. Showalter*, Agnes Witkiewicz, Joseph A. Cozzitorto, Patricia K. Sauter, Eugeen P. Kennedy, Charles J. Yeo, Jonathan R. Brody

SSAT Poster Session 8:00 AM - 5:00 PM

MAY 21

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION III: BASIC / SMALL BOWEL W1842

Small Bowel Engineering Using Small Intestinal Submucosa (SIS) Syde A. Taheri*, Umesh Patel, William Van Alstine, Merril T. Dayton

W1843

Diurnal Regulation of Drug Transporters in the Small Bowel Adam T. Stearns*, Anita Balakrishnan, David B. Rhoads, Stanley W. Ashley, Ali Tavakkolizadeh

Denotes DDW Poster of Distinction

W E D N E S D A Y

P-325

POSTER SESSIONS—COMBINED COMBINED AASLD Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

W1860

Fibrosing Cholestatic Hepatitis: A Seven-Case Study Xinqing Fan*, Shu-Yuan Xiao

W1861

Liver Test Abnormalities in Patients with Choledocholithiasis and/or Cholecystitis Manmeet S. Padda*, Shou Jiang Tang, Don C. Rockey

AUTOIMMUNE LIVER DISEASE/CHOLESTASIS W1846



Recurrent Urinary Tract Infection in Mice Results in Immune-Mediated Cholangiopathy Similar to Human Primary Biliary Cirrhosis Joseph J. Palermo

W E D N E S D A Y

W1847

Prevalence and Determinants of PSC in a Cohort of Patients with Inflammatory Bowel Disease and Normal Liver Function Tests Helen K. Bungay, Otto C. Buchel*, Simon Travis, Fraser Cummings, Roger W. Chapman

MAY 21

W1849

Minocyline in the Treatment of Patients with Primary Sclerosing Cholangitis: Results of a Pilot Study Marina Silveira*, Andrea A. Gossard, Roberta A. Jorgensen, Jill C. Keach, Janice L. Petz, Keith D. Lindor

W1850

AASLD Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

METABOLIC AND HEREDITARY LIVER DISEASE W1862



Proteoliposomes Containing Sendai Virus FGlycoprotein for Hepatocyte-Targeted Gene Therapy of the Gunn Rat Model of Crigler-Najjar Syndrome Type 1 Xia Wang*, Debi P. Sarkar, Prashant Mani, Clifford J. Steer, Betsy T. Kren, Rituparna Moitra, Yong Chen, Namita RoyChowdhury, Jayanta Roy-Chowdhury

W1863



Niemann-Pick C1 Protein Transports Copper to the Secretary Compartment from Late Endosomes Where Atp7b Resides Chikatoshi Yanagimoto*, Masaru Harada, Hiroto Kumemura, Hironori Koga, Takumi Kawaguchi, Shinichiro Hanada, Eitaro Taniguchi, Kunihiko Terada, Takato Ueno, Toshihiro Sugiyama, Michio Sata

Trends in Incidence and Prevalence of Primary Sclerosing Cholangitis in An Adult Population in Sweden Maria Benito de Valle*, Björn Lindkvist, Einar Bjornsson

W1864



Increased ER Stress, NRF2 Expression and Oxidative Stress in Cyp2e1 Transgenic Mice Fed a High Fat Diet Philip T. Chen*, Elango Kathirvel, Kengathevy Morgan, Timothy R. Morgan

The Clinical Spectrum and the Prognosis of Adult Patients with Primary Sclerosing Cholangitis in a Population Based Study in Sweden Maria Benito de Valle*, Björn Lindkvist, Riadh Sadik, Einar Bjornsson

W1865



N-Acetyl Cysteine Ameliorates Liver Injury in Patients with Erythropoietic Protoporhyria Jan Petrasek*, Jan Sperl, Sona Frankova, Mohamed S. Farrag, Iva Subhanova, Libor Vitek, J. Spicak, Pavel Martasek

Arterial Stiffness and Endothel Function in Patients with Primary Biliary Cirrhosis Timea Csak*, Jozsef Egresits, Levente Babos, Andrea Horvath, Janos Osztovits, Zsolt Visnyei, Zoltan Jarai, Ferenc Szalay

W1866



Duodenal and Hepatic Gene Expression in Untreated C282y Homozygous Hereditary Haemochromatosis Patients Eleanor Ryan*, Sharon Barrett, Jens Stolte, Martina Muckenthaler, Barry Kelleher, John P. Crowe

W1854

Dominant Bile Duct Stenoses and Biliary Candida Infections Affect Survival in Primary Sclerosing Cholangitis Daniel Gotthardt*, Gerda Rudolph, Petra Kloeters-Plachky, Peter Sauer, Hasan Kulaksiz, Adolf Stiehl

W1867

Copper Overload Leads to Fragmentation of Mitochondrial Membrane Lipids: Implications for the Pathogenesis of Liver Toxicity in Wilson Disease Irina Yurkova, Franziska Stuckert, Jacqueline Lessig, Juergen Arnhold, Dominik Huster*

W1855

Small Duct Primary Sclerosing Cholangitis: Signs of Progression in a Prospective Long Term Follow Up Study Carlos Guma*, Luis A. Viola, Marcelo Thome, Alfredo Facelli, Estela Alvarez, Romina Moretti

W1868

Analysis of Hepatic Ultrasound Imaging and Gene Mutations in Wilson Disease Dominik Huster*, Joachim Mossner, Michael Troeltzsch

W1869

W1856

Characterizing Primary Sclerosing Cholangitis At An Urban US Hospital Toyia James-Stevenson*, Kristina Chacko, Eli Rosenberg, Mohammad Wehbi, Kamil Obideen

Discrepancy in Neurologic Status and Liver Dysfunction in Fulminant Hepatic Failure, Leading to the Discovery of a Missense Mutation Causing Ornithine Transcarbamylase Deficiency in An Adult Douglas J. Renton*, John J. Cannella, Daniel F. Schafer

W1857

Ursodeoxycholic Acid in Primary Sclerosing Cholangitis: A Systematic Review and Meta-Analysis Mohamed O. Othman*, Archana Kaza, Abhishek Choudhary, Matthew L. Bechtold, Srinivas R. Puli, Jeffrey C. Dunkelberg, Praveen K. Roy

W1870

Replacement of Zinc By Copper in Nuclear Receptors May Contribute to the Pathogenesis of Wilson's Disease Ajay K. Jain*, Ke Ma, David D. Moore

W1871

A Rare Presentation of Hepatocellular Carcinoma Lydia Aye*, Ester C. Little, Ann C. Moore, Geetha Kolli, Alberto X. Ramos, Mark N. Wong, Kaya Fox, Richard A. Manch

W1848

W1852

W1853

Keratin Variants Associate with Primary Biliary Cirrhosis Bi hui Zhong*, Pavel Strnad, Guo-Zhong Tao, Carlo Selmi, Pietro Invernizzi, Angelo Caleffi, Antonello Pietrangelo, Eric M. Gershwin, Bishr Omary

W1858

A Novel ABCB4 Mutation Associated with Cholelithiasis and Contraceptive Pill Related Cholestasis Paul Frankish*, Veronique D. Barbu

W1859

Jaundice and Elevated Transaminases in Legionnaire's Disease Jesse Vozick*, S.Ian Gan

P-326

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED W1872

Indications for Orthotopic Liver Transplantation (Oltx) and Graft Survival Time in the American Indian (Ai) Population: A 20 Year Retrospective Study Tamara L. Bernard*, Timothy M. McCashland, Mark E. Mailliard

W1881

The Yield of Endoscopic Surveillance of Pre-Malignant Gastric Lesions: Optimalization of Biopsy Strategies Annemarie C. de Vries*, Jelle Haringsma, Richard A. de Vries, Frank T. Borg, Nicole C. van Grieken, Herman van Dekken, Ernst J. Kuipers

W1873

Factors Contributing to the Low Rate of HCV Evaluation in HIV/HCV Co-Infected Cohort Renee Pozza*, Fatma Barakat, Ed Barber, Karel Biando, Khaled Selim, William C. Mathews, Tarek Hassanein

W1882

W1874



Access to Liver Transplantation: Indirect Measures of Delayed Referral Victoria C. Zacharias*, Nyingi Kemmer, Tiffany E. Kaiser, Rosann Giesting, Dilynn Russell, Guy W. Neff

Identification of Smoking As a Risk Factor for Gastric Intestinal Metaplasia Kate Holmes*, Brian J. Egan, Zaid S. Heetun, Niall Breslin, Barbara M. Ryan, Niall Swan, Humphrey J. O'Connor, Colm A. O'Morain

W1883

Sporadic Duodenal Adenomas and Colorectal Neoplasia in a Hispanic Population Johanna Bigio*, Doris H. Toro

W1875

Erythropoietin Use in Patients On Chronic Hepatitis C Treatment: Incidence of Thromboembolic Events and Hepatocellular Carcinoma Kristina T. Werner*, Marianne J. Rosati, Hugo E. Vargas, Thomas Byrne, Jorge L. Rakela

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

NON-REFLUX ESOPHAGEAL DISORDERS Participants will be able to: • Update in non-reflux esophageal disorders.

Sponsored by: Esophageal, Gastric & Duodenal Disorders

ENDOSCOPIC DETECTION OF PREMALIGNANT LESIONS OF THE UGI TRACT Participants will be able to: • Learn new endoscopic technology for evaluation of UGI tract premalignant lesions. W1876



W1877

W1878

W1879



W1880

Are Biopsies After Ablation for Dysplastic Barrett's Esophagus of Adequate Depth to Detect Glandular Mucosa Beneath the Neosquamous Epithelium? Comparative Histopathological Outcomes from a Randomized, Sham-Controlled Trial (Aim Dysplasia Trial) Nicholas J. Shaheen*, John R. Goldblum, Richard E. Sampliner, Amitabh Chak, Kenneth K. Wang, M. Brian Fennerty, Robert H. Hawes, John G. Hunter Inter-Observer Variability in the Assessment of NBI Mucosal and Vascular Patterns in Barrett's Esophagus (Be) Patients: A Multi-Center Study Ajay Bansal*, Amit Rastogi, Wouter L. Curvers, Mohammed A. Kara, Christopher R. Lynch, Sachin B. Wani, Frans T. Peters, Krishna Pondugula, Sharad C. Mathur, John D. Keighley, Jacques J. Bergman, Prateek Sharma Endoscopic Mucosal Resection (EMR) As a Diagnostic Tool in Barrett's Esophagus (Be) Patients with HighGrade Dysplasia (HGD) and Early Esophageal Adenocarcinoma (EAC): A Systematic Review Hari Sayana, Sachin B. Wani*, John D. Keighley, Ajay Bansal, Amit Rastogi, Sharad C. Mathur, Prateek Sharma The Use of Narrow Band Imaging with Zoom Magnification for the Endoscopic Diagnosis of High Risk Duodenal Adenomas in Patients with Familial Adenomatous Polyposis Syndrome Frank J. van den Broek*, Karam S. Boparai, Susanne van Eeden, Paul Fockens, Elisabeth M. Mathus-Vliegen, Evelien Dekker Endoscopic Interobserver Agreement for the Spigelman Classification in Patients with Familial Adenomatous Polyposis (FAP) Is Only Moderate Jan-Werner Poley*, Evelien Dekker, Fokko M. Nagengast, Elisabeth M. Mathus-Vliegen, Wim C. Hop, Jan Dees, E. J. Kuipers

W1884



Yield of Multiple Rapid Swallowing (MRS) As a Complementary Test During Standard Esophageal Manometry Fernando Fornari*, Ivana Bravi, Roberto Penagini, Jan F. Tack, Daniel Sifrim

W1885

Reversibility of Esophageal Dysmotilities After Conversion from Gastric Band to Gastric Bypass Jan Borovicka, Boudewijn van der Weg, Martin Thurnheer, Bernd Schultes, Claudia Grübel, Patrizia Kuenzler, Daniel Pohl, Michael Fried, Christa Meyenberger, Radu Tutuian*

W1886

Association Between Bronchial Hyperesponsiveness (Bhr) and Esophageal Dysmotility (ED) in Patients Who Were Suspected of Gastroesophageal Reflux Disease (GERD) Roongruedee Chaiteerakij*, Somkiat Wongtim, Sutep Gonlachanvit

W1887

Hyperdynamic Upper Esophageal Sphincter Pressure: A Manometric Marker of Globus Sensation Faiz Mirza, John E. Pandolfino, Peter J. Kahrilas, Monika A. Kwiatek*

W1888

A New Technique of Through-the-Scope, Wire-Guided Esophageal Dilation for the Treatment of Esophageal Food Impaction Ali Siddiqui*, William Harford, Stuart J. Spechler

W1889

Long Term Outcome Following Pneumatic Dilatation for Idiopathic Achalasia Tim Elliott*, Peter I. Wu, Sergio E. Fuentealba, Michal M. Szczesniak, David de Carle, Ian J. Cook

W1890

Utilizing Intraluminal Pressure Gradients to Assess Treatment Outcome in Achalasia Thomas B. Nealis*, William J. Bulsiewicz, Sudip K. Ghosh, Jennifer M. Post, John E. Pandolfino, Peter J. Kahrilas

W1891

In Patients with Anorexia Nervosa, Esophageal Symptoms Are Not Associated with Abnormal Manometry Fosca de Iorio*, Tiziana Todesco, Riccardo Dalle Grave, Caterina Cusumano, Italo Vantini, Luigi Benini

W1892

Chest Pain in Patients with Achalasia - a Frequent Symptom Effectively Treated with Botulinum Toxin Jan Martinek*, Tomas Hucl, Barbora Svobodova, J. Spicak

Denotes DDW Poster of Distinction

P-327

W E D N E S D A Y MAY 21

POSTER SESSIONS—COMBINED W1893

W1894

W1895

W E D N E S D A Y

Assessing Dysphagia During Stationary ImpedanceMonitoring (MII-EM): How Well Do Liquid and Solid Swallows Reproduce Patients' Symptoms? Patrick Janiak*, Daniel Pohl, Edoardo Savarino, Michael Fried, Radu Tutuian Motts Applesauce Is a Cost Effective Substitute for the Proprietary Viscous Solution in Impedance-Manometry Studies Geoffrey Spencer*, David C. Metz, David A. Katzka, YuXaio Yang, Colleen M. Brensinger, Robin Obelmejias Esophageal Achalasia and Risk of Cancer: A Retrospective Cohort Study in Italy Mario Costantini*, Elena Finotti, Christian Rizzetto, Paola Zambon, Stefano Guzzinati, Lisa Zanatta, Martina Ceolin, Emanuela Guirroli, Loredana Nicoletti, Giovanni Zaninotto, Alberto Peracchia, Ermanno Ancona

W1896

Combined Multichannel Intraluminal Impedance and Manometry in Systemic Sclerosis Fosca de Iorio*, Alessandra Garribba, Anna Rostello, Domenico Biasi, Tiziana Viaro, Paola Caramaschi, Lisa M. Bambara, Italo Vantini, Luigi Benini

W1897

Incidence of Esogastric Injuries Following Radiofrequency Ablation of Atrial Fibrillation or Flutter: Preliminary Results of a Prospective Study Severine Hommel*, Philippe R. Ducrotte, Guillaume Savoye, Stephane Lecleire, Frederic Anselme, Arnaud Savoure, Michel Antonietti

W1898

Interobserver Agreement for Impedance Manometry Findings in Patients with Non-Obstructive Dysphagia Daniel Pohl*, Edoardo Savarino, Mentore Ribolsi, Michael Fried, Radu Tutuian

W1899

Use of a Multichannel Intraluminal Impedance- and pHMonitoring System to Assess Esophageal Transport Function Johannes Lenglinger*, Martina Seifert, Margit Eisler, Claudia Ringhofer, Johannes Zacherl, Gerhard Prager, Martin Riegler

W1900

Value of Spatiotemporal Representation of Manometric Data Claudia Grübel*, Richard Hiscock, Geoff Hebbard

W1901

The Utility of Software Analysis of Peristalsis in Esophageal Manometry Studies of Patients with Achalasia Phil A. Hart*, Dawn L. Francis

MAY 21

W1901a Eotaxin-3 Immunofluorescence in Adults with Dysphagia: More to Eosinophilic Esophagitis Than Meets the Microscopic Eye Edward J. Frech*, Mae F. Go, Kristen Thomas, Frederic Clayton, Scott K. Kuwada, Kathryn A. Peterson W1901b Eotaxin-3 Immunofluorescence in Children and Adults with Eosinophilic Esophagitis Edward J. Frech*, Mae F. Go, Kristen Thomas, Amy Lowichik, Kathryn A. Peterson



W1901c Adults with Eosinophilic Esophagitis: What Is the Utility of Routine Allergy Evaluation? Joshua D. Penfield*, David Lang, Eiza L. Ching, Ilche T. Nonevski, Gary W. Falk

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sponsored by: Esophageal, Gastric & Duodenal Disorders

NON-VARICEAL UGI BLEEDING Participants will be able to: • Learn progress in issues related to non-variceal UGI bleeding; and • Review recent research in the area of non-variceal UGI bleeding. W1902



Influence of Aspirin and Non-Steroidal AntiInflammatory Drug (NSAID) Use On the Outcomes of Bleeding Peptic Ulcers: 10 Year Experience of a Specialised Bleeding Unit Umesh Basavaraju*, John M. Thomson, David L. Armour, Norman A. Mowat, Andrew Fraser

W1903

The Frequency and Outcome of Outpatient Management of Nonvariceal Upper GI Hemorrhage: A PopulationBased Analysis Gregory S. Cooper*, Tzuyung D. Kou, Richard C. Wong

W1904

Proton Pump Inhibitors Versus Histamine 2 Receptor Antagonists or Sucralfate for Stress Related Mucosal Bleeding Prophylaxis in Critically Ill Patients: A FollowUp Meta-Analysis Co Q. Pham, Alan Barkun*, Marc Bardou, Myriam Martel

W1905

Systematic Review of the Predictors of Recurrent Hemorrhage After Endoscopic Hemostatic Therapy for Bleeding Peptic Ulcers Scott D. Young*, B. Joseph Elmunzer, Loren A. Laine, Philip S. Schoenfeld, John M. Inadomi

W1906

Intragastric Acid Control with Intravenous Esomeprazole in Critically Ill Patients David C. Metz*, Gerard Fulda, Keith M. Olsen, John T. Monyak, Steven G. Simonson, Mark B. Sostek

W1907

Gastro-Intestinal Bleedings (GIB) and Antiplatelet Agents (Apa). a Nationwide Hospital-Based Observational Survey Including 1010 Consecutive Patients Bernard Nalet*, Jean-François Bretagne, Gilles Lesur, Bruno Bour, Christine Soufflet, Philippe Barthelemy

W1908

No Additive Effect of Somatostatin to Proton Pump Inhibitor in Patients with Peptic Ulcer Bleeding Yoon-Seon Lee*, In Sung Kim, Won Kim, Kyung Soo Lim

W1909

Effect of Intravenous Infusion Versus Intravenous Bolus OMEPRAZOLE in Patients with Bleeding Peptic Ulcer Choo Hean Poh*, Kwong Ming Fock, Eng Kiong Teo, Tiing Leong Ang, Jessica Tan, Lian Hoe Gan, Andrew Kwek, Kieron B. Lim, David Ong

W1910

3-Year Retrospective Study and 1-Year Prospective Evaluation of a Clinical Guideline Recommending Early Discharge in Selected Patients with Low-Risk NonVariceal Upper Gastrointestinal Bleeding (UGIB) Maria Chaparro, Felipe de la Morena, Almudena Barbero, L. Martin Martín, Carlos Esteban, L. Espinosa, Argeme Sanchez, I. Martin, Ricardo Moreno-Otero, Javier P. Gisbert*

W1911

Risk Factors for Rebleeding and Death in Bleeding Ulcers Treated with High Dose PPI and Bipolar Probe Francine Fein, Stephane Koch, Audrey Weber, Anne Claire Dupont Gossart, Jean Paul Cervoni, Georges Mantion, Franck Carbonnel*

W1912

Acute Non-Variceal Upper Gastrointestinal Bleeding in Israel 1995-2004: A Significant Decrease in Incidence, Related to a Decrease in Peptic Ulcer Bleeding Tiberiu Hershcovici*, Ziona Haklai, Ethel-Sherry Gordon, Joseph Zimmerman



P-328

Sails Pavilion San Diego Convention Center

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED W1913

The Relationship Between H. pylori Negative Peptic Ulcer and Gastrointestinal Bleeding:a Prospective MultiCenter Case-Control Study in China Yiqi Du*, Zhaoshen Li, Pingping Diao

W1914

Characteristics of GI Bleeding Occurring in Patients On Antiplatelet Therapy. Results of a Prospective Cohort of Patients Recruited in 61 French Hospitals Jean-François Bretagne*, Bernard Nalet, Gilles Lesur, Bruno Bour, Philippe Barthelemy, Christine Soufflet

W1915

Endoscopic Argon Plasma Coagulation for the Treatment of Gastric Antral Vascular Ectasia (GAVE) in Patients with Hemorrhagic Diathesis Due to Liver Cirrhosis Rocco Maurizio Zagari, Lorenzo Fuccio*, Marta Serrani, Diego Grilli, Vincenzo Cennamo, Liboria Laterza, Franco Bazzoli

AGA Institute Poster Session 8:00 AM - 5:00 PM

W1924

Prevalence and Clinical Impact of Upper Gastrointestinal Symptoms in Patients Treated with Low-Dose Aspirin Gerard Thiefin*, Gilles Montalescot, France Woimant, Philippe Barthelemy, Christine Soufflet

W1925

Gastroprotection in Patients At Risk of Gastrointestinal NSAID Complications: Results of a General Practitioner Based Survey in France Gerard Thiefin*, Pierre-Henri Delaage, Philippe Barthelemy

W1926

Serotonin Selective Reuptake Inhibitors (SSRIs) Are Not Associated with An Increased Risk of Upper Gastrointestinal Events in Users of Non-Steroidal AntiInflammatory Drugs (NSAIDs) Laura E. Targownik*, Colleen J. Metge, Stella Leung

W1927

Low Dose Aspirin Affects the Small Bowel Mucosa. Results of a Pilot Study Using a Multidimensional Assessment Edgardo Smecuol, Maria Ines Pinto Sanchez, Alejandro Suarez, Julio E. Argonz, Emilia Sugai, Horacio Vazquez, Nestor Litwin, Elena Piazuelo, Eduardo Mauriño, Jonathan B. Meddings, Julio C. Bai*, Angel I. Lanas

W1928

Evaluation of Provider Adherence to Clinical Guidelines for Gastroprotection in Patients At Increased Risk of NSAID Associated GI Bleeding, in Response to Education Intervention Ruben D. Acosta*, Ryan A. Bell, Brooks D. Cash

Sails Pavilion San Diego Convention Center

Sponsored by: Esophageal, Gastric & Duodenal Disorders

NSAIDS: CLINICAL STUDIES AND MECHANISMS OF INJURY AND REPAIR Participants will be able to: • Learn about advances in NSAID-related disorders. W1916



Early Mortality After Upper Gastrointestinal Bleeding and the Use of Low-Dose Aspirin and Anti-Thrombotic Therapy and Non-Steroidal Anti-Inflammatory Drugs Ali S. Taha*, Wilson J. Angerson, Rakesh Prasad, Caroline McCloskey, Danielle K. Gilmour

W1917



Endoscopic Gastroduodenal Ulcers (Gdus) in NSAID Arms in Randomized Placebo-Controlled NSAID Trials (Rcts): A Meta-Analysis Yu-Hong Yuan, Chang Cheng Wang, Yuhong Yuan, Richard H. Hunt*

W1918



Does Concomitant Use of Acetaminophen Potentiate the Gastroduodenal Mucosal Injury of Aspirin: A Prospective, Randomized, Pilot Study Justin R. Boike, Brian Markle, David Meyer, Roger Kao, Jonathan A. Rosenberg, Adam C. Stein, Joshua Niebruegge, Jamie L. Berkes, Jay L. Goldstein*

W1920

Study of Relationship Between Intragastric pH and Gastric Mucosal Lesions Induced By Low-Dose Aspirin in Healthy Volunteers Masafumi Nishino*, Mitsushige Sugimoto, Chise Kodaira, Mihoko Yamade, Mutsuhiro Ikuma, Akira Hishida, Takashi Ishizaki, Takahisa Furuta

W1921

Characteristics and Impact of Upper GI Symptoms in Patients Treated with NSAIDs: Results of a Cross Sectional Epidemiological Study in Primary Care Gerard Thiefin*, Flipo René-Marc, Thierry Schaeverbecke, Christine Soufflet, Philippe Barthelemy

W1922

Epidemiological Characteristics of Low-Dose Aspirin Treatment and Gastroprotection in France: Results of a Nation-Wide Postal Survey Gerard Thiefin*, Gilles Montalescot, France Woimant, Christine Soufflet, Philippe Barthelemy

W1923

Thirty-Day Mortality After Peptic Ulcer Perforation and the Use of Low-Dose Aspirin and Non-Steroidal AntiInflammatory Drugs Ali S. Taha*, Wilson J. Angerson, Rakesh Prasad, Caroline McCloskey, Danielle K. Gilmour

W1929

Upper Gastrointestinal Ulcer in Japanese Patients Taking Low Dose Aspirin Akiko Shiotani*, Takashi Sakakibara, Maki Takami, Yoshiyuki Yamanaka, Hiroshi Imamura, Ken-ichi Tarumi, Noriaki Manabe, Tomoari Kamada, Hiroaki Kusunoki, Ken Haruma

W1930

Modalities of Low-Dose Aspirin Treatment and Gastroprotective Strategies in General and Specialty Practice in France Gerard Thiefin*, France Woimant, Gilles Montalescot, Philippe Barthelemy, Christine Soufflet

W1931

Meta-Analysis: Risk of Upper Gastrointestinal Event with Over-the-Counter Non-Steroidal Anti-Inflammatory Drugs. Svetang V. Desai*, Conar P. Fitton, Diana L. Castillo, Neena S. Abraham

W1932

Gastroprotective Strategies Are Underutilized in HighRisk Patients Using Cardioprotective Doses of Aspirin Laura E. Targownik*, Colleen J. Metge, Stella Leung

W1933

The Effect of Lafutidine On the Prevention of Low-Dose Aspirin Plus Loxoprofen-Induced Gastric Damage -a Randomized, Double-Blinded, Placebo-Controlled, Crossover Study Mototsugu Kato*, Go Kamada, Shoko Ono, Manabu Nakagawa, Souichi Nakagawa, Yuichi Shimizu, Masahiro Asaka

W1934

Examination of Gastrointestinal Mucosal Damage Induced By Low-Dose Aspirin Tomoyuki Shibata*, Tomomitsu Tahara, Tomiyasu Arisawa, Masakatsu Nakamura, Daisuke Yoshioka, Hiroaki Shimazaki, Ichiro Hirata, Hiroshi Nakano

W1935

Low Dose Aspirin and On Demand User of NonSteroidal Anti-Inflammatory Drugs Are Risk Factors for Bleeding Peptic Ulcer in Japan Masayuki Nakayama*, Kotaro Mannen, Kazuma Fujimoto, Ryuichi Iwakiri

W1936

Up-Regulation of Gadd45a Expression By NSAIDs in Gastric Injury Shiun-Kwei Chiou

Denotes DDW Poster of Distinction

P-329

W E D N E S D A Y MAY 21

POSTER SESSIONS—COMBINED

W E D N E S D A Y MAY 21

W1937

Prevention of Diclofenac Enteropathy By Levamisole CoTreatment Mary Treinen-Moslen*, Volker Neugebauer, Weidong Li, Lata Kaphalia, Veronica Ramirez-Alcantara, Judith Aronson, Tor Savidge

W1948

Colonic Adenomatous Polyps Modulation of the Local Microflora: A Potential Pro-Carcinogenetic Factor? Cristiano Pagnini*, Vito D. Corleto, Simona Torre, Giancarlo D'Ambra, Emilio Di Giulio, Fabio Cominelli, Gianfranco Delle Fave

W1938

Mitochondria But Not Cell Membrane Are Primary Target of Indomethacin and NS-398-Induced Injury and Prostaglandin E2 Afforded Protection of Gastric Epithelial Cells Patrick B. Truong*, Amrita Ahluwalia, Andrzej Tarnawski

W1949

W1939

Effect of Cobiprostone On Naproxen-Induced Gastric Ulcers in Rats Hiroyoshi Osama, Sachiko Kuno, Birgit Roerig*, Ryuji Ueno

C-MET Amplification in Oesophageal Adenocarcinoma Cell Lines Influences EGFR and Erbb2 Phosphorylation Status and May Provide Resistance to ERBB Targeted Therapies Anna L. Paterson*, Hong Shi, Li Liu, Tona M. Gilmer, Richard F. Wooster, Rebecca Fitzgerald

W1950

Ritonavir, a Protease Inhibitor, Induces Apoptosis in Pancreatic Cancer Cells By Inhibiting the AKT Signaling Pathway Christopher S. Bryant*, Sanjeev Kumar, Bassel El-Rayes, Aamer Qazi, Christopher P. Steffes, Madhu Prasad, Donald W. Weaver, Masood A. Shammas, Ramesh B. Batchu

W1951



Sorafenib (Nexavar®) Treatment Enhances TrailMediated Apoptosis in Human Pancreatic Cancer Cells Shengbing Huang, Frank A. Sinicrope*

W1952

Identification of Novel Small Molecule Compounds That Inhibit the Pro-Proliferative Krüppel-Like Factor 5 By High-Throughput Screening Agnieszka Bialkowska*, Yuhong Du, Haian Fu, Vincent W. Yang

W1953

Effect of a Novel Telomerase Inhibitor, Grn163l, On Growth of Barrett's Esophageal Adenocarcinoma Cells In Vitro and In Vivo Masood A. Shammas*, Aamer Qazi, Ramesh B. Batchu, Robert C. Bertheau, Jason Y. Wong, Manjula Y. Rao, Christopher S. Bryant, Sanjeev Kumar, Madhu Prasad, Selvarangan Ponnazhagan, Diptiman Chanda, Christopher P. Steffes, Nikhil C. Munshi, Immaculata De Vivo, David G. Beer, Sergei Gryaznov, Donald W. Weaver, Raj K. Goyal

W1954

Sulforaphane, An Antioxidant Derived from Broccoli, Induces Apoptotic Cell Death in Barrett's Esophageal Adenocarcinoma Cells Masood A. Shammas*, Christopher S. Bryant, Sanjeev Kumar, Madhu Prasad, Christopher P. Steffes, David G. Beer, Raj K. Goyal

W1955



Resveratrol Analogues with Potent Anticarcinogenic Properties Sandra Ulrich*, Aleksandra Zivkovic, Andrea Huwiler, Holger Stark, Jürgen Stein

W1956

Sorafenib Triggers Antiproliferative and Pro-Apoptotic Signals in Human Esophageal Adenocarcinoma Cells Jorge-Shmuel Delgado*, Reba Mustafi, Sonia R. Cerda, Anusara Chumsangsri, Urszula Dougherty, Jason Yee, Lev Lichtenstein, Alessandro Fichera, Marc Bissonnette

W1957

Novel Migrastatin Analogues Reduce Gastric Cancer Cell Migration Without Exhibiting Cytotoxic Effects Gareth Horgan*, David W. Murray, Aideen Madden, Gayle Bennett, John Ryan, Guillaume Anquetin, Murphy V. Paul, Padraic MacMathuna, Peter Doran

W1958

Activation and Increased Cytolytic Activity of Tumor Specific T Lymphocytes After Laser-Induced Thermotherapy (Litt) in Patients with Colorectal Liver Metastases Thaddaeus T. Wissniowski*, Matthias Ocker, Eckhart G. Hahn, Deike Strobel

W1959

Bh3 Mimetic Abt-737™ and CPT-11 Act Synergistically to Induce Apoptosis in Human Colon Carcinoma Cells Kenji Okumura*, Shengbing Huang, Frank A. Sinicrope

W1940

W1941

W1942

NSAID Activated Gene (NAG-1) Plays a Role in the Impairing Effects of Cyclooxygenase Inhibitors On Gastric Ulcer Repair Rocchina Colucci*, Narcisa Ghisu, Luca Antonioli, Matteo Fornai, Nunzia Bernardini, Chiara Ippolito, Mario Del Tacca, Corrado Blandizzi Increased Susceptibility to NSAID-Induced GI Injury in Rats with Chronic Spinal Cord Injury (Sci) and It's Reversal with PC-NSAIDs Shiqiang Tian*, Nicholas A. Stephens, Lenard M. Lichtenberger Interaction of Bile Acids and Nonsteroidal AntiInflammatory Drugs (NSAIDs) Leads to Membrane Destabilization: A Potential Explanation for NSAIDInduced Small Intestinal Injury Yong Zhou*, Rand Doyen, Lenard M. Lichtenberger

W1943

Aspirin-Induced Mucosal Cell Death in Human Gastric Cells: Evidence Supporting a Caspase-Independent Mechanism Anna M. Leung*, Maria J. Redlak, Thomas A. Miller

W1944

Leukotriens May Play An Important Role in NSAIDInduced Intestinal Hyper-Motilities and Lesion Formation in Cats Hiroshi Satoh*, Kana Hatao, Sachiko Shiotani

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: NOVEL THERAPEUTIC AND TRANSLATIONAL APPROACHES Participants will be able to: • Evaluate novel therapeutic and translational approaches in GI oncology. W1945

Efficacy of Autologous HSP70-Rich Tumor Vaccine Satoshi Kokura*, Tetsuya Okayama, Satoko Adachi, Tomohisa Takagi, Osamu Handa, Yuji Naito, Toshikazu Yoshikawa

W1946

A Novel Small-Molecule Aurora Kinase Inhibitor with Strong Antiproliferative Activity in Human Carcinoid Cell Lines Daniel Benten*, Katharina Fraedrich, Jorg Schrader, Gunhild Keller, Arthur Gontarewicz, Arno Kromminga, Ansgar W. Lohse, Jurgen Moll, Tim Brummendorf, Michael Blaker

W1947

The Antineoplastic Effects of Taurolidine in Ct26 Murine Colorectal Adenocarcinoma Nick Clarke*, Edward McSwiney, Jiang Huai Wang, Paul Redmond

P-330

Authors must be present during the Poster Session from 12:00-2:00 pm.

POSTER SESSIONS—COMBINED W1960

Reactive Oxygen Species Induced By the Compound Bisphenol-a-Diglycidyl-Ether Cause Senescence and Apoptosis in Colorectal Cancer Cell Lines Regardless of MDR1 or p53 Status Gianni Harris, Katherine L. Schaefer*

W1971

Nitric Oxide Mediates the Warburg Effect in Gastric Epithelial and Cancer Cells Hirofumi Matsui*, Yumiko Nagano, Osamu Shimokawa, Tsuyoshi Kaneko, Jumpei Udo, Takashi Mamiya, Kanho Rai, Ichinosuke Hyodo, Kozi Nakai

W1961

Novel p53-Derived Peptide Induces Extensive Necrosis in Cancer Cells Kelley A. Sookraj*, Victor Adler, Ehsan Sarafraz-Yazdi, Martin Bluth, Michael E. Zenilman, Josef Michl, Matthew R. Pincus, Wilbur B. Bowne

W1972

COX-Derived PGE2 Modulates Fasl Expression Via the Ep1 Receptor in Colon Cancer Cells. Aileen Houston*, Grace P. O'Callaghan, Fergus Shanahan

W1973

Constitutive Activation of Ikk/Nf-κB in Colorectal Cancer Cells Plays Critical Role in Tumor Growth and Angiogenesis Kei Sakamoto*, Shin Maeda, Yohko Hikiba, Hayato Nakagawa, Wataru Shibata, Ayako Yanai, Keiji Ogura, Masao Omata

W1962

Suppression of Prohb-EGF Carboxy Terminal Fragment Nuclear Translocation Might Be a New Molecular Targeting Therapy for Gastric Cancer Takaya Shimura*, Hiromi Kataoka, Makoto Sasaki, Eiji Kubota, Tsuneya Wada, Tsutomu Mizoshita, Takashi Joh

AGA Institute Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

W1974



CDx2 Induces Icam2 Expression and Promotes In Vitro Angiogenesis Sang Chun, Kyunghee Burkitt, John P. Lynch, Marcia R. Cruz-Correa, Long H. Dang, Duyen Dang*

W1975

Genetic Inhibition of Telomerase Leads to Induction of ALT in Immortalized Human Esophageal Epithelial Cells and in Generated Human Squamous Cancer Cells Angela Queisser*, Michaela Thaler, Alexander von Werder, Eva Egenter, Steffen Heeg, Nina Hirt, Heike Kunert, Sarah Hauss, Hideki Harada, Hiroshi Nakagawa, Shang Li, Elisabeth H. Blackburn, Hubert E. Blum, Oliver G. Opitz

Sponsored by: Gastrointestinal Oncology

GI ONCOLOGY: TUMOR CELL BIOLOGY, MICROENVIRONMENT AND ANGIOGENESIS Participants will be able to: • Review recent research in tumor cell biology, microenvironment and angiogenesis. W1963



Sumoylation Enhances Nuclear Localization of KrüppelLike Factor 5 Vincent W. Yang*, James X. Du

W1964



Telomerase Reverse Transcriptase Regulation By TGF-β Signaling Through Adaptor ELF and SMAD3 That Is Independent of C-MYC Zhixing Yao*, Youngwoo Kim, Rupen Amin, Eugene A. VOLPE, Wilma S. Jogunoori, Lopa Mishra, Bibhutibushan Mishra

W1965

Uncoupling Protein-2 Alters the p53 Response and the Bioenergetics of Colon Cancer Cells Zoltan Derdak*, Nicholas M. Mark, Tamako A. Garcia, Guido Beldi, Simon C. Robson, Jack R. Wands, Gyorgy Baffy

W1966

Hom-1 Inhibits Tumor Growth in Both p53 Sufficient and Deficient Colon Cancer Cells Hong (Jenny) Gao*, Bin Wu, Roger Giese, John R. Saltzman, Zhenglun (Jerry) Zhu

W1967

Colon Cancer Cells and Anoikis Resistance: EGFRDependent Sustained Activation of the SRC-MEK/ERK Pathway Can Override Dependance On FAK, PI3-K/AKT1 for Survival. Pierre H. Vachon

W1968

Human Gastric Cancer-Associated Fibroblast-Like Cells Are Derived from the Bone Marrow Daniel L. Worthley*, Andrew Ruszkiewicz, Ruth Davies, Sarah Moore, Simon Durrant, Robyn Western, Ian NivisonSmith, Charles G. Mullighan, Peter Browett, Bik To, Graeme P. Young, Peter G. Bardy, Michael Michael

W1969

Translation Control During Mitotic Catastrophe: Mcl-1 Is a Novel Target for RNA Binding Protein CUGBP2 Dharmalingam Subramaniam*, Satish Ramalingam, Gopalan Natarajan, Ilangovan Ramachandran, Randal May, Lurdes Queimado, Courtney W. Houchen, Shrikant Anant

W1970

Increased Extracellular Pressure Enhances Cancer Cell β1-Integrin Binding Affinity Through Phosphorylation of β1-Integrin At Threonine 788/789 David H. Craig*, Yanzhang Wei, Marc D. Basson

W1976

Opposing Effects of Deoxycholic Acid and Ursodeoxycholic Acid On Golgi Structure; Implications for Colon Cancer Progression Anne-Marie Byrne*, Eilis Foran, Ruchika Sharma, Anthony M. Davies, Dermot P. Kelleher, Aideen Long

W1977

Trastuzumab Induced CTL Responses Against Esophageal Cancer Are Inhibited By Down-Regulation of the Antigen Processing Machinery Component Tap2 Francesca Milano*, Agnieszka M. Rygiel, Wytske Westra, Kausilia K. Krishnadath

W1978

B7-H1 Is Highly Expressed in Gastric Carcinoma and Suppresses Intratumor T Cell Immune Response Zhanju Liu*, Shuman Liu

W1979

Telomerase Activity and Telomere Length in Lcm Purified Barrett's Esophageal Adenocarcinoma Cells Masood A. Shammas*, Aamer Qazi, Ramesh B. Batchu, Jason Y. Wong, Manjula Y. Rao, Christopher S. Bryant, Sanjeev Kumar, Madhu Prasad, Christopher P. Steffes, Immaculata De Vivo, David G. Beer, Donald W. Weaver, Raj K. Goyal

W1980

Immortalization and Characterization of a Human Colonic Epithelial Cell Line Andres I. Roig*, Suzie K. Hight, Jerry W. Shay

W1981

Lysyl Oxidase Like Protein 2 (Loxl2) and Loxl3 Expression Is Up-Regulated in Colorectal Carcinoma Matti Waterman*, Shelly Zafriar, Rami Eliakim, Ofer BenIzhak, Gera Neufeld

W1982

Malignant Transformation of Rat Gastric Epithelial RGM-1 Cell Line Induced By Carcinogen N-Methyl-N'Nitro-N-Nitrosoguanidine (Mnng) Treatment Was Accompanied with the Ectopic Expression of H+,K+Adenosine Triphosphatase (ATPase) Osamu Shimokawa*, Hirofumi Matsui, Tsuyoshi Kaneko, Yumiko Nagano, Jumpei Udo, Takashi Mamiya, Kanho Rai, Akira Nakahara, Ichinosuke Hyodo

W1983

Identification of Putative Functional Domains of Human Trefoil Factor Family-3 (TFF3) Matthew Diamond*, Xiuliang Bao, Harel Weinstein, Lawrence Werther, Steven H. Itzkowitz

Denotes DDW Poster of Distinction

P-331

W E D N E S D A Y MAY 21

POSTER SESSIONS—COMBINED

W E D N E S D A Y MAY 21

W1984

Depletion of the Colonic Epithelial Precursor Cell Compartment Upon Conditional Activation of the Hedgehog Pathway Willemijn A. van Dop*, Anja Uhmann, Mark Wijgerde, Johan Offerhaus, Guy E. Boeckxstaens, Marius A. van den Bergh Weerman, Daniel W. Hommes, James C. Hardwick, Heidi Hahn, Gijs R. van den Brink

W1985

MicroRNA Expression Profiling of Colorectal Cancer and Its Precancerous Lesions Using Lna™ Oligonucleotide Arrays Lieke Hol*, M. E. Leerdam van, Antonius W. Boersma, E. J. Kuipers, Erik A. Wiemer

W1986

Cxcl8/IL-8 and Cxcl12/Sdf-1α Cooperatively Promote Invasion and Angiogenesis of Pancreatic Cancer Yoichi Matsuo*, Sushovan Guha

W1987

Hyperthermia Cancels Tumor-Associated Immune Suppression Satoko Adachi*, Satoshi Kokura, Tetsuya Okayama, Osamu Handa, Tomohisa Takagi, Yuji Naito, Toshikazu Yoshikawa

W1988

Depletion of Mast Cells Causes Regression of Adenomatous Polyps Khashayarsha Khazaie*, Elias Gounaris

W1989

The Co-Expression of Peroxisome Proliferator-Activated Receptor Delta and Cyclooxygenase-2 May Enhance the Angiogenesis and Tumor Venous Invasion in Tissues of Colorectal Cancers Masahiro Yoshinaga*, Yosuke Kitamura, Tomohito Chaen, Shinsaku Yamashita, Satoru Tsuruta, Teruaki Hisano, Hironori Sakai, Kazuhiko Nakamura, Ryoichi Takayanagi, Yoichi Muto

W1990

Cross Talk Between Colonic Fibroblasts and Colon Cancer Cells Up-Regulates COX 2 and Cyclin D1: Role of EGFR Reba Mustafi*, Anusara Chumsangsri, Sonia R. Cerda, Urszula Dougherty, Jorge-Shmuel Delgado, Alessandro Fichera, Marc Bissonnette

W1991

Upregulation of Epithelial Mesenchymal Transition in Colorectal Cancer After PTEN Knockdown Kanika A. Bowen*, Binhua P. Zhou, Hung Q. Doan, B. M. Evers

W1992

Extracellular HSP70 Blocks Cd40l-Induced Apoptosis and Tubular Formation in Endothelial Cells Seiji Futagami*, Tetsuro Hiratsuka, Tomotaka Shindo, Nobue Ueki, Tatsuhiko Hamamoto, Masafumi Kusunoki, Kazumasa Miyake, Katya Gudis, Taku Tsukui, Choitsu Sakamoto

SSAT Poster Session 8:00 AM - 5:00 PM

Sails Pavilion San Diego Convention Center

SSAT POSTER SESSION III: COMBINED W1993

Single Incision Laparoscopic Cholecystectomy Using Flexible Endoscopy: Saline Infiltration Gallbladder Fossa Dissection Technique John N. Afthinos*, Glenn Forrester, Steven Binenbaum, Eugenius J. Harvey, M. J. Latif, Scott J. Belsley, Ninan Koshy, James J. McGinty, Domingo C. Nunez, George J. Todd, Grace J. Kim, Julio Teixeira

W1994

The Effect of Bariatric Surgery On Non-Alcoholic Fatty Liver Disease Mankanwal S. Sachdev*, David S. Tichansky, Atul K. Madan

W1995

Impact of Gastric Irrigation On NOTES Mesh Placement Lauren Buck*, Joel E. Michalek, Samer Sbayi, Kent Van Sickle, Wayne H. Schwesinger, Juliane Bingener

P-332

Authors must be present during the Poster Session from 12:00-2:00 pm.