Program the Annual Meeting of the American Gastroenterological Association and Digestive Disease Week

April 1998

PI PROGRAMOF THE ANNUALMEETING

PROGRAM THE ANNUAL MEETING OF THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION AND DIGESTIVE DISEASE WEEK SUNDAY, MAY 17, 1998 8:00-12:00 p m Page P9

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AASLD P l e n a r y S e s s i o n Ballroom A / B AASLD P o s t e r S e s s i o n Cellular and molecular biology Alcohol and biotransformation Biliary tract and gallstones Viral hepatitis C: treatment Viral hepatitis B and other viral hepatitis Chronic cholestatic and autoimmune liver disease Hepatocellular injury and carcinogenesis Liver transplantation Hepatoeellular carcinoma and biliary cancer Hall D AGA P o s t e r S e s s i o n Esophageal, Gastric, and Duodenal Disorders Cell biology of secretion Esophageal, Gastric, and Duodenal Disorders Regulation of mucus and bicarbonate secretion Esophageal, Gastric, and Duodenal Disorders Regulation of gastric acid secretion Esophageal, Gastric, and Duodenal Disorders Antisecretory drugs: pharmacodynamics and pharmacokinetics Esophageal, Gastric, and Duodenal Disorders Mechanisms of mucosal protection Esophageal, Gastric, and Duodenal Disorders Mucosal injury and repair Esophageal, Gastric, and Duodenal Disorders Ulcer healing Esophageal, Gastric, and Duodenal Disorders NSAIDs: clinical aspects Esophageal, Gastric, and Duodenal Disorders NSAIDs: basic mechanisms Esophageal, Gastric, and Duodenal Disorders Helicobacterpylari: epidemiology and natural history Pancreatic Disorders - Cell physiology and neurohormonal regulation Biliary Disorders - Motility and pathophysiology Gastrointestinal Oncology - Molecular genetics of gastrointestinal cancer I Gastrointestinal Oncology - Growth factors, signal transduction and transcription factors Gastrointestinal Oncology- Clinical and epidemiological studies Gastrointestinal Oncology - Diagnosis: serum and tissue markers Gastrointestinal Oncology - Diagnosis and staging Motility and Nerve-Gut Interactions - Cell physiology of nerves and gut muscle Motility and Nerve-Gut Interactions - Extrinsic and intrinsic innervation Motility and Nerve-Gut Interactions Oropharyngeal motility Motility and Nerve-Gut Interactions Esophageal motility: basic science Motility and Nerve-Gut Interactions Esophageal motility: clinical science Immunology, Microbiology, and Inflammatory Disorders - Nitric oxide and inflammation Immunology, Microbiology, and Inflammatory Disorders - IBD: inflammation and nonimmune cells Immunology, Microbiology, and Inflammatory Disorders - IBD: disease assessment Immunology, Microbiology, and Inflammatory Disorders - Intestinal infections

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P o s t e r S e s s i o n (cont'd) Hormones, Transmitters, Growth Factors and their Receptors - Physiology and cell biology I Hormones, Transmitters, Growth Factors and their Receptors - Receptor characterization and regulation Hall D

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GRG/AGA S p r i n g S y m p o s i u m Water and solute transport across intestional epithelia: emerging mechanisms and current controversies Room 99 State of t h e A r t L e c t u r e Intestinal gas revisited Room 90/91/92 AGA Clinical S y m p o s i u m Contemporary issues in nutrition Room 58/59/60 AGA T o p i c F o r u m ECL cells: receptors and function Room 80/81 AASLD Research Fora Treatment of viral hepatitis Ballroom C Liver injury and fibrosis Room 93 / 94 Liver transplantation I Room 95/96 AGA Clinical S y m p o s i a Multidisciplinary approach to chronic abdominal pain Room 58/59/60 Metabolic, endocrine and gastrointestinal disorders in drug use and HIV/AIDS Room 97/98 GI complications of diabetes mellitus Room 90/91/92 AGA R e s e a r c h S y m p o s i u m Wound healing/restitution and repair Room 80/81 AGA T o p i c F o r u m Clinical pharmacology of IBD therapy Room 6 4 / 6 5 / 6 6 AASLD Research Fora Pathogenesis and natural history of hepatitis C Room 85 / 86 Cytokines and alcohol Room 93 / 94 Liver transplantation II Room 95/96 AGA R e s e a r c h F o r a Motility and Nerve-Gut Interactions Interstitial cells and smooth muscle types Room 82/83 Immunology, Microbiology, and Inflammatory Disorders- Pathogenesis of GI and hepatic infections Room 89 AASLD P o s t e r D i s c u s s i o n Room 58/59/60

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DDW T r a i n e e S y m p o s i u m

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Howto get a job in academia or clinical practice Room Oak Alley, Hilton Riverside Hotel

All sessions located in the Ernest N. Morial Convention Center unless otherwise noted

GASTROENTEROLOGY Vol. 114, No. 4

P2 PROGRAMOF THE ANNUAL MEETING

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MONDAY, MAY 18, 1998 8:00-5:00 p m Page P53 2:15-3:45 p m Page P57

SSAT P o s t e r S e s s i o n Hall D

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SSAT Scientific P r e s e n t a t i o n s R e s e a r c h papers I Room 9 7 / 9 8

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SSAT C o n s e n s u s R o o m 103 / 104

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DDW C o m b i n e d Clinical S y m p o s i u m Chronic ulcerative colitis Ballroom C

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SSAT Scientific P r e s e n t a t i o n s R e s e a r c h papers II Room 9 7 / 9 8

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A S G E Video F o r u m

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Room 100 / 101 / 102

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A G A P o s t e r S e s s i o n (cont'd) I m m u n o l o g y , Microbiology, a n d I n f l a m m a t o r y Disorders - IBD: i m m u n o l o g y a n d pathogenesis I m m u n o l o g y , Microbiology, a n d I n f l a m m a t o r y Disorders - IBD: clinical f e a t u r e s Hormones, Transmitters, Growth Factors a n d their Receptors - Physiology a n d cell biology II Hormones, T r a n s m i t t e r s , G r o w t h Factors a n d their Receptors - B r a i n - g u t axis Hall D AASLD Poster Session Lipids a n d v i t a m i n s Genetic liver disease a n d gene t h e r a p y Hepatic blood flow Portal h y p e r t e n s i o n a n d complications of

cirrhosis Viral hepatitisC: pathogenesis and immunology Viral hepatitis C: diagnosis and markers Cytokines and fibrosis

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DDW C o m b i n e d Clinical S y m p o s i u m I n t e r a c t i o n of a c e t a m i n o p h e n a n d NSAIDs with alcohol: n a m e y o u r poison Ballroom C

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AGA Clinical S y m p o s i u m C o m p u t e r s a n d t h e gastroenterologist - 1998 Room 4 1 / 4 2

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DDW C o m b i n e d Clinical S y m p o s i u m Chronic ulcerative colitis Ballroom C

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A G A State of the Art Lecture

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DDW C o m b i n e d Clinical S y m p o s i a Interaction of a c e t a m i n o p h e n a n d NSAIDs with alcohol: n a m e your poison Ballroom C

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AGA Clinical S y m p o s i a Celiac disease Room 6 1 / 6 2 / 6 3 C u r r e n t issues in T P N Room 85 / 86 Advances in obesity Room 99 New pancreatic i m a g i n g modalities Hall C

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AGA P l e n a r y S e s s i o n Hall C

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DDW Meet-the-Investigator/ Meet-the-Professor L u n c h e o n s

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Hall D

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AGA P o s t e r S e s s i o n Clinical Practice - I E s o p h a g e a l , Gastric, a n d Duodenal Disorders Helicobacter pylori: t h e r a p y I n t e s t i n a l Disorders - Clinical I n t e s t i n a l Disorders - Intestinal t r a n s p o r t I I n t e s t i n a l Disorders - Mucosal repair a n d protection Pancreatic Disorders - E x p e r i m e n t a l pancreatitis Biliary Disorders - Diagnosis G a s t r o i n t e s t i n a l Oncology - Eicosinoids, cyclooxygenases a n d NSAIDs G a s t r o i n t e s t i n a l Oncology - Proliferation a n d apoptosis G a s t r o i n t e s t i n a l Oncology - Gastrointestinal cancer susceptibility: clinical studies G a s t r o i n t e s t i n a l Oncology - C a n c e r in c h r o n i c u l c e r a t i v e colitis G a s t r o i n t e s t i n a l Oncology - Colon cancer screening Motility a n d N e r v e - G u t Interactions - Gastric motility: basic science Motility a n d N e r v e - G u t Interactions - Gastric motility: clinical science Motility a n d N e r v e - G u t Interactions - Gastric m o t o r function t e s t s Motility a n d N e r v e - G u t Interactions - Small i n t e s t i n e motility: basic science Growth, Development, Nutrition - Nutrition: basic science Growth, Development, Nutrition - Nutrition: clinical a n d applied science I m m u n o l o g y , Microbiology, a n d I n f l a m m a t o r y Disorders - Mucosal immunology

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L e s s o n s from t h e colonic a d e n o m a Ballroom A / B

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AGA Research Symposium

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AGA Topic Fora Innovations in medical t h e r a p y for IBD Room 1 3 / 1 5 / 1 7 Barrett's esophagus Room 8 2 / 8 3 C o m m o n clinical d i l e m m a s - a n evidence-based approach Room 90/91/92

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C u r r e n t topics in c o m p a r a t i v e gastroenterology: viral h e p a t i t i s a n d h e p a t i c carcinogenesis R o o m 80/81

AASLD Research Fora Clinical hepatelogy Room 9 3 / 9 4 Hepatocyte a n d cholangiocyte biology Room 95/96

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AGA R e s e a r c h F o r u m Biliary Disorders - Gallbladder a n d s p h i n c t e r of Oddi motility Room 20

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AGA R e s e a r c h Fora Motility a n d N e r v e - G u t Interactions - Acute effects of i n f l a m m a t o r y m e d i a t o r s a n d growth factors Room 22

All sessions located in the Ernest N. Morial Convention Center unless otherwise noted

PROGRAMOF M

Apri]1998

ANNUALMEETING P3

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AGA R e s e a r c h Fora (cont'd) Immunology, Microbiology, and Inflammatory Disorders - Human IBD pathogenesis Room 24 Motility and Nerve-Gut Interactions Sphincters Room 28 Pancreatic Disorders - Ethanol and the pancreas Room 33/35 Esophageal, Gastric, and Duodenal Disorders Dyspepsia and Helicobacter pylori Room 58/59/60 Hormones, Transmitters, Growth Factors and their Receptors - Molecular biology Room 88 Immunology, Microbiology, and Inflammatory Bowel Disorders - Mucosal immunology I Room 89

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AGA Clinical S y m p o s i u m Securing your financial future Room 4 1 / 4 2

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AGA State of the Art Lectures Peptide receptor signaling Room 22 Antibiotic resistance in Helicobacterpylori Room 64/65/66 Cell adhesion, migration, and signalling: crosstalk involving cadherin, catenins, and APC protein Room 99 New treatments of viral hepatitis Hall C

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DDW C o m b i n e d Clinical S y m p o s i a Molecular pathogenesis of viral hepatitis Room 5 8 / 5 9 / 6 0 Chronic ulcerative colitis Ballroom C AGA Clinical S y m p o s i a Outcomes in gastroesophageal reflux Room 90/91/92 The enteric nervous system and its friends: links with accessory organs and prevertebral ganglia Room 28 AGA R e s e a r c h S y m p o s i u m Immune-non-immune interactions in intestinal inflammation Room 85/86

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AGA Topic F o r u m Receptor binding domains Room 33/35 AASLD R e s e a r c h F o r a Hepatobiliary surgery Room 93/94 Bile formation and eholestasis Room 95/96 AGA R e s e a r c h F o r a Growth, Development, Nutrition - Mucosal growth factors Room 20 Gastrointestinal Oncology- Colonic adenoma detection and surveillance Room 13/15/17 Esophageal, Gastric, and Duodenal Disorders Basic mechanisms of NSAID-induced injury Room 21 Esophageal, Gastric, and Duodenal Disorders Cell biology of acid Secretion Room 24 Intestinal Disorders - Clinical advances in intestinal disorders I Room 61/62/63 Gastrointestinal Oncology- Molecular pathogenesis of gastrointestinal cancer Room 80 / 81 Growth, Development, Nutrition - Nutrition: clinical Room 82/83 Pancreatic Disorders - Integrated pancreatic physiology Room 88 AGA S e c t i o n a l B u s i n e s s Meetings Hormones, Transmitters, Growth Factors, and their Receptors Room 22 Motility and Nerve-Gut Interactions Room 28 Esophageal, Gastric, and Duodenal Disorders Room 88 Intestinal Disorders Room 99 IBD F o r u m S y m p o s i u m Management of complex perianal Crohn's disease in the new millennium Grand Salon D, Hilton Riverside Hotel

All sessions located in the Ernest N. Morial Convention Center unless otherwise noted

P4 PROGRAMOF THE ANNUALMEETING

GASTROENTEROLOGYVol. 114, No. 4

TUESDAY, MAY 19, 1998 8:00-9:30 a m Page P l l 0

ASGE Topic F o r u m GI bleeding Ballroom C

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ASGE Clinical S y m p o s i u m Endoscopic mueosal resection/ablation Room 64/65/66

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DDW C o m b i n e d C l i n i c a l S y m p o s i u m Gastric dyspepsia Ballroom A / B

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ASGE Topic F o r u m ERCP Ballroom C

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DDW C o m b i n e d C l i n i c a l S y m p o s i a Occult GI bleeding Room 90/91/92 H. pylori: consensus and controversy Ballroom A / B

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ASGE Topic F o r u m Esophagus Ballroom C ASGE P e d i a t r i c S y m p o s i u m Therapeutic endoscopy in children/ endoscopic evaluation for dyspepsia Room 61/62/63

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ASGE Topic F o r u m Pediatric endoscopy Room 61/62/63

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ASGE Topic F o r u m Endoscopic ultrasound Room 61/62/63 DDW Combined Clinical Symposia Minimally invasive management of common bile duct stones Ballroom A / B Severe acute pancreatitis Room 100/101/102

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ASGE Clinical S y m p o s i u m Virtual endoscopy Ballroom C

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ASGE Clinical S y m p o s i u m Device reprocessing Ballroom C

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DDW Combined Clinical Symposia HIV: GI manifestations Room 90/91/92 Recent advances in the treatment of intestinal failure Room 100/101/102

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ASGE P o s t e r S e s s i o n Endoscopic technology: special imaging, resection and mucosectomy Endoscopic technology: stents, ultrathin and other endoscopic technology Pediatric endoscopy E R C P - biliary: training, safety and outcomes E R C P - biliary: pancreatitis and other complications E R C P - biliary: sphincter of Oddi disorders, stricture and stents E R C P - biliary: cholelithiasis and other stone diseases ERCP - malignant stricture, cancer, and other biliary ERCP ERCP - pancreas Endoscopic ultrasound: methods and upper GI tract Endoscopic ultrasound: biliary, pancreas, intestine and abdomen Hall D

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Poster Grand Rounds Esophagus Stomach and duodenum/GI bleeding Colon and rectum Room 80 / 81

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DDW C o m b i n e d C l i n i c a l S y m p o s i u m Ethics in liver transplantation: pursuing excellence in the managed care era Room 100/101/102

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SSAT S c i e n t i f i c P r e s e n t a t i o n s Clinical papers I Room 103 / 104 DDW C o m b i n e d Clinical S y m p o s i u m Occult GI bleeding Room 90/91/92 SSAT S c i e n t i f i c P r e s e n t a t i o n s Clinical papers II Room 103/104

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DDW C o m b i n e d C l i n i c a l S y m p o s i a Minimally invasive management of common bile duct stones Ballroom A / B Severe acute pancreatitis Room 100/101/102 Hepatocellular cancer Room 90/91/92

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SSAT Scientific P r e s e n t a t i o n s Clinical papers III Room 103/104

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SSAT S c i e n t i f i c P r e s e n t a t i o n s Clinical papers IV Room 103/104 Focused Clinical/Research Updates

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AGA R e s e a r c h S y m p o s i u m Funding opportunities in GI research Room 37

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AGA B u s i n e s s M e e t i n g

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AGA S t a t e of t h e Art L e c t u r e s Function and dysfunction of the biliary epithelium: clinical implications Room 85/86 Common diagnostic errors in GI pathology: when to ask for an expert opinion Room 90/91/92 DDW C o m b i n e d C l i n i c a l S y m p o s i a Gastric dyspepsia Ballroom A / B Ethics in liver transplantation: pursuing excellence in the managed care era Room 100/101/102

AGA Clinical S y m p o s i u m Colon cancer screening and surveillance Room 41/42/43 AGA R e s e a r c h S y m p o s i a Animal models relevant to pancreatic disease Room 93/94 The epithelial response to stress Room 97/98 AGA Topic F o r u m Fundie relaxation: perception, dyspepsia, and pain Room 40 AASLD R e s e a r c h F o r a Autoimmune liver diseases Room 80/81 Genetic liver diseases Room 82/83

All sessions located in the Ernest N. Morial Convention Center unless otherwise noted

April 1998

PROGRAMOF THE ANNUALMEETING P5

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AGA Research Fora Immunology, Microbiology, and Inflammatory Disorders - Mucosal immunology II Room 11 Pancreatic Disorders - Clinical pancreatitis Room 1 3 / 1 5 / 1 7 Immunology, Microbiology, and Inflammatory Disorders - Mucosal inflammation Room 19 Gastrointestinal Oncology - Cyclooxygenases, eicosanoids, and carcinogenesis Room 33/35 Esophageal, Gastric, and Duodenal Disorders Helicobacter pylori pathogenesis: effects at the gastric mucosal surface Room 38 Hormones, Transmitters, Growth Factors and their Receptors - Mediators of epithelial cell growth and proliferation Room 44 Esophageal, Gastric, and Duodenal Disorders Helicobacterpylori and gastroesophageal reflux disease Room 58 / 59 / 60 Intestinal Disorders - Cellular and molecular biology of the enterocyte Room 88 Motility and Nerve-Gut Interactions - Intrinsic reflexes Room 89 Growth, Development, Nutrition - Nutrition: basic science Room 95 / 96 AGA S t a t e of t h e A r t L e c t u r e s The cellular and molecular basis of Hirschprung's disease Room 64 / 65 / 66 The molecular genetics of pancreatic carcinoma Room 85/88 DDW C o m b i n e d Clinical S y m p o s i a H. pylori: consensus and controversy Ballroom A / B Occult GI bleeding Room 9 0 / 9 1 / 9 2 AGA C l i n i c a l S y m p o s i a Extraintestinal manifestations of IBD: diagnosis, m a n a g e m e n t and indications for referral of ocular dermatologie and rheumatologic complications Room 58 / 59 / 60 Anorectal disease in clinical practice Room 100/101]102 AGA R e s e a r c h S y m p o s i a Tight junctions: molecular regulation and involvement in intestinal pathology Room 97/98 The role of COX-2 and nitric oxide in mucosal pathophysiology Room 99 AASLD R e s e a r c h F o r a Portal hypertension: clinical research Room 80/81 Growth and apoptosis Room 82/83 AGA R e s e a r c h F o r a Immunology, Microbiology, and Inflammatory Disorders - M e c h a n i s m s of mueosal immunity and inflammation Room 11 Biliary Disorders - Diagnosis and t r e a t m e n t of biliary disease Room 1 3 / 1 5 / 1 7 Immunology, Microbiology, and Inflammatory Disorders - Pathogenesis of Crohn's disease Room 19 Gastrointestinal Oncology - Mechanisms of apoptosis Room 33/35

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A G A R e s e a r c h F o r a (cont'd) Esophageal, Gastric, and Duodenal Disorders Mechanisms of mucosal injury and adaptation Room 38 Gastrointestinal Oncology - Colon cancer screening Room 4 1 / 4 2 / 4 3 Hormones, Transmitters, Growth Factors and their Receptors - Knockout mice: lessons for gut messenger s y s t e m s Room 44 Immunology, Microbiology, and Inflammatory Disorders - Microbial pathogenesis Room 89 Esophageal, Gastric, and Duodenal Disorders GI toxicity of NSAIDs: magnitude, cause, and prevention Room 93/94 Intestinal Disorders - Clinical advances in intestinal disorders II Room 95/96 DDW Meet-the-Investigator/ Meet-the-Professor Luncheons

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AGA P o s t e r S e s s i o n Clinical practice - II Esophageal, Gastric, and Duodenal Disorders Helicobacter pylori: pathogenesis Intestinal Disorders - Enterocyte molecular biology Intestinal Disorders - Epithelial pathobiology and mucosal inflammation Pancreatic Disorders - Pancreatitis: clinical studies Biliary Disorders - Gallstones and other biliary disease Gastrointestinal Oncology- Molecular genetics of gastrointestinal cancer II Gastrointestinal Oncology- Regulation of proliferation, differentiation and apoptosis Gastrointestinal Oncology - Prognosis and metastasis: clinical studies Gastrointestinal O n c o l o g y - Hclicobacter pylori: gastrointestinal cancer Motility and Nerve-Gut Interactions - Experimental models of small intestine motility Motility and Nerve-Gut Interactions - Small intestine motility: clinical science Motility and Nerve-Gut Interactions Gallbladder motility Motility and Nerve-Gut Interactions - Colonic motility: basic science Motility and Nerve-Gut Interactions Anorectal motility: clinical science Motility and Nerve-Gut Interactions Anorectal motility: basic science Growth, Development, Nutrition - Mucosal growth factors Growth, Development, Nutrition Gastrointestinal development: cellular and molecular biology Growth, Development, Nutrition - Pediatric and gastrointestinal liver disease Growth, Development, Nutrition - Aging Immunology, Microbiology, and Inflammatory Disorders - I B D : animal models and preclinical t r e a t m e n t Immunology, Microbiology, and Inflammatory Disorders - IBD: genetics Immunology, Microbiology, and Inflammatory Disorders - Microbial pathogenesis Immunology, Microbiology, and Inflammatory Disorders - Helicobacterpylori: bacteriology and immunology Hormones, Transmitters, Growth Factors and their Receptors - Molecular biology Hormones, Transmitters, Growth Factors and their Receptors - Neurobiology Hormones, Transmitters, Growth Factors and their Receptors - Biology of growth factors I Hall D

All sessions located in the Ernest N. Morial Convention Center unless otherwise noted

P6 PROGRAMOF THE ANNUALMEETING

GASTROENTEROLOGYVol. 114, No. 4

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AGA State of the Art Lectures Neuro-modulation of gut inflammation Room 64 / 65 / 66 Genetic screening for colon cancer: why, when and how should it be used? R o o m 58 / 59 / 60 DDW C o m b i n e d Clinical S y m p o s i a Minimally invasive m a n a g e m e n t of common bile duct stones Ballroom A / B Hepatocellular cancer Room 9 0 / 9 1 / 9 2 Severe acute pancreatitis Room 1 0 0 / 1 0 1 / 1 0 2 AGA Clinical S y m p o s i a Controversies in upper GI bleeding: an evidence-based approach Room 4 1 / 4 2 / 4 3 Management of achalasia Room 99 AGA R e s e a r c h S y m p o s i a Regulation of transcription and apoptosis in the gut epithelium Room 89 TGF beta in cancer biology Room 9 3 / 9 4 Purinergic receptors in the gastrointestinal tract Room 9 7 / 9 8

AGA Topic Fora Pathophysiology of biliary diseases Room 3 3 / 3 5 Economic outcomes for clinical practice Room 3 7 / 3 8 Immunomodulation in IBD Room 85 / 86 AGA R e s e a r c h Fora Gastrointestinal Oncology - Helicobacter pylori and GI cancer Room 1 3 / 1 5 / 1 7 Hormones, Transmitters, Growth Factors and Their Receptors - Brain-gut axis Room 19 Pancreatic Disorders - Experimental pancreatitis Room 28 Motility and Nerve-Gut Interactions - Colonic transit Room 40 Motility and Nerve-Gut Interactions - Irritable bowel and pain perception Room 44 Esophageal, Gastric, and Duodenal Disorders Helicobacter pylori and apoptosis Room 80 / 81 Immunology, Microbiology, and Inflammatory Disorders - Immunopathobiology of Helicobacter infection Room 82/83 Intestinal Disorders - Regulation of intestinal electrolyte transport Room 9 5 / 9 6

G a s t r o i n t e s t i n a l P a t h o l o g y Society Companion Meeting Controversies in gastrointestinal pathology Room 2 2 / 2 4 DDW C o m b i n e d Clinical S y m p o s i a HIV: GI manifestations Room 9 0 / 9 1 / 9 2 Recent advances in the t r e a t m e n t of intestinal failure Room 1 0 0 / 1 0 1 / 1 0 2

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AGA Clinical S y m p o s i a (cont'd) Minority health issues in gastroenterology: health care utilization and hepatitis C in the minority community Room 89

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AGA R e s e a r c h S y m p o s i a

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Clinical aspects of colon carcinogenesis for the basic scientist and opportunities for research Room 6 1 / 6 2 / 6 3 Recent advances in Helicobacterpylori pathogenesis Room 85 / 86

4:00-5:30 p m Page P177

AGA Topic F o r u m Clinical myths revisited Room 3 7 / 3 8

4:00-5:30 p m Page P177

AGA R e s e a r c h F o r a Esophageal, Gastric, and Duodenal Disorders Bleeding peptic ulcer Ballroom A / B Immunology, Microbiology, and Inflammatory Disorders - Insights into therapeutic mechanisms in IBD Room 11 Gastrointestinal Oncology - Gastric preneoplasia and Helicobacter pylori Room 1 3 / 1 5 / 1 7 Immunology, Microbiology, and Inflammatory Disorders - Mucosal immunity and inflammation: IL-10 Room 19 Motility and Nerve-Gut Interactions - Fat, glucose and motility Room 28 Hormones, Transmitters, Growth Factors and their Receptors - Physiology/cell biology Room 3 3 / 3 5 Pancreatic Disorders - Cystic fibrosis and the pancreas Room 40 Motility and Nerve-Gut Interactions - IBS: evaluation of t r e a t m e n t and m a n a g e m e n t Room 8 0 / 8 1 Gastrointestinal Oncology - Growth factors, growth factor receptors and cancer Room 9 3 / 9 4 Intestinal Disorders - Cellular mechanisms of intestinal electrolyte transport Room 9 5 / 9 6 Growth, Development, Nutrition Transcriptional regulation of gut gene expression Room 9 7 / 9 8 Esophageal, Gastric, and Duodenal Disorders Mucosal defense and repair: growth factors and angiogenesis Room 99

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AGA Sectional B u s i n e s s Meetings Immunology, Microbiology, and Inflammatory Disorders Room 19 Clinical Practice Room 37 Pancreatic Disorders Room 40 Biliary Disorders Room 58 / 59 / 60 Gastrointestinal Oncology Room 93 / 94 Growth, Development, Nutrition Room 9 7 / 9 8

AGA Clinical S y m p o s i a Controversies in biliary pancreatitis Room 5 8 / 5 9 / 6 0 Gastrointestinal disorders in children Room 6 4 / 6 5 / 6 6 All sessions located in the Ernest N. Morial Convention Center unless otherwise noted

PROGRAM OF THE ANNUAL MEETING P7

April 1998

II 7:15 a m

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WEDNESDAY, MAY 20, 1998 ASGE A n n u a l B u s i n e s s M e e t i n g Ballroom C ASGE Plenary Session

ASGE C l i n i c a l S y m p o s i u m Multi-media - endoscopic record Room 93/94

2:15-3:45 p m Page P183

ASGE T o p i c F o r u m New technology in endoscopic practice Room 61/62/63

2:15-3:45 p m

ASGE C l i n i c a l S y m p o s i u m Vital staining/chemoendoscopy Room 100/101/102

4:00-5:30 p m

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ASGE C l i n i c a l S y m p o s i a Endotherapy of pancreatic disease Room 100/101/102 Minimal standards Room 97/98 ASGE Poster Session

Clinical endoscopic practice:education and training Clinical endoscopic practice:cost and open access Clinicalendoscopic practice:outcomes research Clinicalendoscopic practice:disinfection, reprocessing and disposables Clinical endoscopic practice:sedation and control of patient anxiety Clinical endoscopic practice:safety, complications and other clinicalendoscopy Gastroesophageal reflux and Barrett's esophagus Esophageal cancer Varices, achalasia and other clinical esophagoscopy GI bleeding Helicobacter pylori and other gastroduodenal ulcer diseases Gastric cancer and other diseases of stomach and duodenum P E G and other upper GI endoscopy Colon: adenoma, polyp, cancer Colitisand other colonoscopy Endoscopic technology: EUS, fluorescenceand spectroscopictechnologies Hall D

5:30-6:30 p m

Poster Grand Rounds

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ERCP-biliary ERCP-pancreas Endoscopic ultrasound Room 80/81

7:00-8:15 a m

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Ballroom C

2:15-3:45 p m Page P183

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8:30-9:30 a m

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8:30-10:00 a m

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SSAT Business Meeting

Room 103 / 104 Presentation of the Founders Medal

Room 103 / 104

8:30-I0:00 a m

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SSAT Scientific Presentations

Clinical papers V Room 103/104

AGA S t a t e o f t h e A r t L e c t u r e s Hereditary pancreatitis: new insights Room 58/59160 Bacteria and biofilm: implications for the biliary tract Room 80/81 Intestinal bile acid transport: molecules, mechanisms, and malabsorption Room 99 AGA C l i n i c a l S y m p o s i a Pseudoobstruction: genes, interstitialcells, channels and significanceof basic advances Room 61/62/63 Management of the patient following liver transplantation Room 90/91/92 Cancer risk in Barrett's esophagus Room 100/101/102 AGA R e s e a r c h S y m p o s i u m Biologic basis of colorectal cancer risk Room 33/35 AGA R e s e a r c h F o r a Hormones, Transmitters, Growth Factors and their Receptors - Visceral pain Room 11 Immunology, Microbiology, and Inflammatory Disorders - IBD genetics Room 13/15/17 Immunology, Microbiology, and Inflammatory Disorders - Animal models of IBD: pathogenesis Room 19 Immunology, Microbiology, and Inflammatory Disorders - Mucosal response to enteric infections Room 44 Growth, Development, Nutrition - Gut gene expression Room 82 / 83 Esophageal, Gastric, and Duodenal Disorders Helico bacter pylori: antimicrobial resistance Room 85 / 86 Pancreatic Disorders - Molecular pancreatology Room 88 Gastrointestinal Oncology- Experimental therapeutics Room 89 Immunology, Microbiology, and Inflammatory Disorders - N a t u r a l history of IBD Room 93/94 Intestinal Disorders - Inflammatory and immune effects on intestinal function Room 95 / 96 Motility and Nerve-Gut Interactions Identification and projection of defined neurons Room 97/98 AGA C l i n i c a l S y m p o s i u m Fraud and abuse rules and the practicing gastroenterologist Ballroom A / B

AGA S t a t e o f t h e A r t L e c t u r e s Infectious diarrheas: a future perspective SSAT Scientific P r e s e n t a t i o n s Room 58 / 59 / 60 Clinical papers VI Trefoil growth peptides in GI tract physiology Page P199 Room 103/104 and pathology Room 93/94 SSAT/SAGES S y m p o s i u m o n M i n i m a l l y Activation of extrinsic sensory nerves of the Page P199 Invasive Surgery bowel Room 103 / 104 Room 97/98 All sessions located in the Ernest N. Morial Convention Center unless otherwise noted 10:30-11:30 a m

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P8 PROGRAMOF THE ANNUALMEETING

GASTROENTEROLOGYVol. 114,No. 4

WEDNESDAY, MAY 20, 1998, (cont'd) 10:30-12:00 p m Page P199 Page P199

AGA Clinical S y m p o s i a Somatostatin analogues: recent advances in clinicaluse Room 61/62/63 Diagnosis, prevention and treatment of steroidinduced bone disease Room 100/101/102

10:30-12:00 p m Page P199

AGA R e s e a r c h S y m p o s i u m Bile acids and the cell Room 80/81

10:30-12:00 p m Page P200

AGA Topic F o r a Epidemiology of GI disease Room 11 Emerging diagnostic modalities in gastroenterology Room 13/15/17

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10:30-12:00 p m Page P200

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12:30-1:45 p m

AGA R e s e a r c h F o r a Immunology, Microbiology, and Inflammatory Disorders - Animal models of IBD: treatment Room 19 Gastrointestinal Oncology- HNPCC and microsatellite instability Room 33/35 Hormones, Transmitters, Growth Factors and their Receptors - Determination of domains critical for receptor activation Room 37 Clinical Practice - Instruments used in outcomes research Room 44 Pancreatic Disorders - Clinical exocrine/ endocrine tumors of the pancreas Room 64/65/66 Esophageal, Gastric, and Duodenal Disorders Helicobacterpylori: diagnostic testing Room 85/86 Gastrointestinal Oncology - Invasion and metastases Room 89 Esophageal, Gastric, and Duodenal Disorders Antireflux surgery Room 90/91/92 Intestinal Disorders - Intestinal adaptation and apoptosis Room 99

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DDW Meet-the-Investigator/ Meet-the-Professor L u n c h e o n s

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8:00-5d)0 p m

Page P237 AGA P o s t e r S e s s i o n Clinical practice -III Esophageal, Gastric, and Duodenal Disorders Helicobacterpylori:diagnosis Esophageal, Gastric, and Duodenal Disorders Gastroesophageal reflux disease Esophageal, Gastric, and Duodenal Disorders Barrett's esophagus Esophageal, Gastric, and Duodenal Disorders Nonreflux esophageal disease Esophageal, Gastric, and Duodenal Disorders Upper gastrointestinal disorders Esophageal, Gastric, and Duodenal Disorders Dyspepsia Intestinal Disorders - Intestinal transport II Intestinal Disorders - Splanchnic circulation and disease Pancreatic Disorders - Chronic pancreatitis and pancreatic cancer: clinicalstudies Biliary Disorders - Treatment Gastrointestinal Oncology- Markers of cancer risk and progression Gastrointestinal Oncology- Preclinical carcinogenesis, invasion and metastasis

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P o s t e r S e s s i o n (cont'd) Gastrointestinal Oncology - Colon cancer chemoprevention Gastrointestinal Oncology - Therapy of gastrointestinal cancers Gastrointestinal Oncology - Barrett's esophagus and esophageal carcinoma Motility and Nerve-Gut Interactions Esophageal motility Motility and Nerve-Gut Interactions Functional gastrointestinal disorders Immunology, Microbiology, and Inflammatory Disorders - Epithelial cell immune functions Immunology, Microbiology, and Inflammatory Disorders - Mucosal infammation and host defense Immunology, Microbiology, and Inflammatory Disorders - IBD: cytokines Immunology, Microbiology, and Inflammatory Disorders - IBD: therapeutics Hormones, Transmitters, Growth Factors and their Receptors - Biology of growth factors II Hall D

AGA Clinical S y m p o s i a Perspectives on current and future therapies for I B D Ballroom C M a n a g e m e n t of ascites Room 58/59/60 AGA R e s e a r c h F o r a Gastrointestinal Oncology- Chemoprevention of GI cancer Room 11 Biliary Disorders - Pathogenesis of gallstenes Room 19 Hormones, Transmitters, Growth Factors and their Receptors - Receptor cycling, internalization and trafficking Room 33/35 Gastrointestinal Oncology- Gastrin and GI neoplasia Room 80/81 Gastrointestinal Oncology- Regulation of proliferation and apoptesis in GI cancer Room 82/83 Esophageal, Gastric, and Duodenal Disorders Pathophysiology of gastroesophageal reflux disease Room 85/86 Esophageal, Gastric, and Duodenal Disorders Helicobactor pylori: therapeutic regimens Room 90/91/92 Motility and Nerve-Gut Interactions Reflections of the gut in the brain Room 99

4.~0-5:30 p m Page P237

AGA Topic F o r u m COX-2: Basic mechanisms and clinical realities Room 85/86

4:00-5:30 p m Page P238

AGA R e s e a r c h Fora Esophageal, Gastric, and Duodenal Disorders Effects of therapy on Helicobacterpyloriassociated gastric preneoplasia Room 64/65/66 Motility and Nerve-Gut Interactions Fibromyalgia, infection, stress and IBS Room 95/96

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4:00-5:30 p m Page P235

I m m u n o l o g y , Microbiology, a n d I n f l a m m a t o r y D i s e a s e s Wrap Up Highlights of Immunology, Microbiology, and Inflammatory Bowel Disease at D D W 9 8 Ballroom C

.4ll sessions located in the Ernest N. Morial Convention Center unless otherwise noted

PROGRAM OF THE ANNUAL MEETING P9

April 1998

II

SUNDAY, MAY 17, 1998 THE AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION

AASLD Plenary Session 8:00-10:00 am Ballroom A / B Ernest N. Morial Convention Center

AASLD Plenary Session 10:00 am-12:00 p m Ballroom A / B Ernest N. Morial Convention Center

Chairs: Neil Kaplowitz, William Lee

Chairs: Joseph Bloomer, William Balistreri

8:00

10:00

The effect of m a i n t e n a n c e i n t e r f e r o n i n c h r o n i c HCV n o n - r e s p o n d e r s : r e s u l t s of a r a n d o m i z e d c o n t r o l l e d t r i a l . (Abstract# L0586) ML Shiffman, CM Hofmann, AJ Sanyal, VA Luketic, RK Sterling, A Ferreira-Gonzalez, M Contose, AS Mills and C Garrett. Richmond, VA

10:15

S u s t a i n e d h i s t o l o g i c r e s p o n s e is c o m m o n i n t h e a b s e n c e of virologic r e s p o n s e to i n t e r f e r o n t h e r a p y for c h r o n i c h e p a t i t i s C. (Abstract# L0382) KL Lindsay, M Mosteller, M Rizzetto, GL Davis, P Opolon, R Goldin, DF Gray, R Boehme and N Brown. Los Angeles, CA; Research Triangle Park, NC; Turin, Italy; Gainesville, FL; Paris, France and London, United Kingdom

10:30

A m o u s e - h u m a n c h i m e r i c m o d e l for i n f e c t i o n a n d r e p l i c a t i o n of h e p a t i t i s v i r u s B in vivo. (Abstract# L0073) J J Brown, B Parashar, E Rabani, D Englhardt, H Moshage, NR Chowdhury and JR Ch0wdhury. Bronx and New York, NY; Gr0ningen, The Netherlands

8:14

L a m i v u d i n e t r e a t m e n t for one y e a r i n p r e v i o u s l y u n t r e a t e d U.S. h e p a t i t i s B p a t i e n t s : histologic improvement and hepatitis Bea n t i g e n s e r o c o n v e r s i o n . (Abstract# L0148) J Dienstag, E Schiff, T Wright, R Perrillo, HW Hann, L Crowther, M Woessner, M Rubin, N Brown and the US Lamivudine Investigator Group. Boston, MA; Miami, FL; San Francisco, CA; New Orleans, LA; Philadelphia, PA and Research Triangle Park, NC Two y e a r l a m i v u d i n e t h e r a p y in c h r o n i c h e p a t i t i s B infection: r e s u l t s of a p l a c e b o c o n t r o l l e d m u l t i c e n t r e s t u d y i n Asia. (Abstract# L0375) YF Liaw, CL Lai, NWY Leung, TT Chang, R Guan, DI Tai, KY Ng, PC Wu, LC Roman, JC Dent and DF Gray. Taiwan; PR China; Singapore and United Kingdom

8:28

Impaired liver regeneration in inducible nitric o x i d e s y n t h a s e - d e f i c i e n t mice. (Abstract# L0522) R Rai, FY Lee, A Rosen, SQ Yang, HZ Lin, C Lowenstein and AM Diehl. Baltimore, MD

8:43

Treatment with interleukin-6 reduces liver damage and apoptotic hepatocyte death and e n h a n c e s r e c o v e r y in a c u t e toxic i n j u r y . (Abstract# L0335) K Kovalovich, EE Furth and R Taub. Philadelphia, PA

10:45

A caspase 8-cathepsin B protease cascade c o n t r i b u t e s to bile s a l t - i n d u c e d h e p a t o c y t e a p o p t o s i s . (Abstract# L0168) WA Faubi0n, PJ Roberts, SF Bronk, LB Agell0n and GJ Gores. Edmonton, Canada and Rochester, MN

8:58

K n o c k o u t of t h e m o u s e H F E gene p r o d u c e s h e m o c h r o m a t o s i s . (Abstract# L0712) XY Zhou, S Tomatsu, RE Fleming, S Parkkila, A Waheed, WS Sly, EM Brunt, Z Tsuchihashi, JN Feder, RC Schatzman, R O'Neill, RS Britt0n and BR Bacon. St Louis, MO and Menlo Park, CA

11:00

E t h a n o l i n c r e a s e s p r o d u c t i o n of lipopolysaccharide binding protein by h e p a t o c y t e s . (Abstract# L0259) K Ikejima, N En0m0t0, A Ikejima, RG Thurman and DA Brenner. Chapel Hill, NC

11:15

9:13

J a n A l b r e c h t C o m m i t m e n t to Clinical Research Award

9:15

IV a l b u m i n p r e v e n t s r e n a l f u n c t i o n impairment and improves survival in spontaneous bacterial peritonitis. A m u l t i c e n t r i c r a n d o m i z e d t r i a l . (Abstract# L0514) R Planas. Barcalona, Spain

Effect of c i s a p r i d e u p o n j e j u n a l b a c t e r i a l f l o r a and bacterial translocation in ascitic cirrhotic r a t s . (Abstract# L0044) R Bartoli, A Pardo, R Planas, B Vifiado, E Cabr~, MP Rodriguez-Iglesias, V Ausina and MA GassuU, Badal0na, Spain

11:30

N e o n a t a l cholestasis: p a t h o g e n e s i s i n t h e cholesterol 7a-hydroxylase-deficient mouse (Cyp 7-/-). (Abstract# L0029) R Arnon, T Yoshimura, NB Javitt and AB Reiss. New York, Ny

11:45

M u t a t i o n s o f A P C gene a n d genes i n v o l v e d in Beckwith-Siedemann syndrome are frequently found in children with hepatoblastoma. (Abstract# L0434) G Montalto, F Cetta, M Negrini, C Schwienbacher, M Gori, A Acquaviva and G Morgese. Siena and Ferrara, Italy

9:30

9:45

Case c o n t r o l s t u d y c o m p a r i n g r e s o u r c e u t i l i z a t i o n a f t e r o p e r a t i v e s h u n t o r T I P S for variceal hemorrhage in child A and B c i r r h o t i c s . (Abstract# L0409) R Maves, K Wicks, K Johanson and S Helt0n. Seattle, WA H e p a t o c y t e t r a n s p l a n t a t i o n in p a t i e n t s w i t h l i v e r c i r r h o s i s . (Abstract# L0056) BM Bilir, D Kumpe, J ICrysl, D Guenette, A Ostrowska, GT Everson, R Shrestha, TC Lin, W Cole, J Lear and JD Durham. Denver, CO

P10 P R O G R A M OF T H E A N N U A L M E E T I N G

G A S T R O E N T E R O L O G Y Vol. 114~ No. 4

II II

It

AASLD Poster Session 8:00-5:00 p m Hall D Ernest N. Morial Convention Center Authors are required to present during the Poster Session from 12:00-2:30 pm

Those posters identified as D D W Posters of Distinction have received review scores that place them within the top 10% of all posters. We encourage you to make them a priority as you visit the poster session. AASLD - - C E L L U L A R A N D M O L E C U L A R BIOLOGY S t r u c t u r e a n d e x p r e s s i o n of Cded, a novel gene e n c o d i n g a P H d o m a i n , m a p s to t h e d i s t a l p o r t i o n of m o u s e c h r o m o s o m e 2. (Abstract# L0706) P Yu, T Cai, SPS Monga, B Mishra and L Mishra. Washington, DC; Philadelphia, PA and Bethesda, MD M o l e c u l a r c l o n i n g a n d e x p r e s s i o n of m o u s e itlb-4: encodes a scaffolding protein in liver formation. (Abstract# L0079) T Cai, P Yu, SPS Monga, B Mishra and L Mishra. Washington, DC; Philadelphia, PA and Bethesda, MD

ell'J, a n o v e l ~-spectrin gene in l i v e r a n d b i l e d u c t d e v e l o p m e n t . (Abstract# G2103) T Cai, P Yu, SPS Monga, B Mishra and L Mishra. Washington, DC; Philadelphia, PA and Bethesda, MD E x p r e s s i o n of syndecan-1, a m e t a s t a s i s s u p p r e s s o r f a c t o r of h e p a t o c e l l u l a r c a r c i n o m a , was useful as a p r o g n o s t i c m a k e r a f t e r s u r g i c a l r e s e c t i o n . (Abstract# L0327) Y Kohgo, M Ohhira, T Ohtake, K Tanaka, K Ikuta, H Sait0h, M Ono and Y Fujimot0. Asahikawa, Japan The e x p r e s s i o n of t h r o m b o s p o n d i n in t h e f i b r o t i c l i v e r of b i l i a r y a t r e s i a . (Abstract# L0447) S Mushiake, K Ozono, Y Etani, H Tajiri and S Okada. Osaka, Japan T h r o m b o p o i e t i n s e c r e t i o n b u t n o t t r a n s c r i p t i o n is d o w n r e g u l a t e d i n v / t r o b y i n t e r f e r o n - a t r e a t m e n t in HepG2 cells. (Abstract# L0682) M Wichlas, C Weidekamm, J Pidlich, A Gangl and M PeckRadosavljevic. Vienna, Austria L o c a l i z a t i o n of t h e r e g i o n i n t h e 5'-flanking s e q u e n c e of r a t g l u t a t h i o n e S - t r a n s f e r a s e A2 gene t h a t m e d i a t e s t h e d e c r e a s e d e x p r e s s i o n c a u s e d b y interleukin-6. (Abstract# L0665) SH Voss, R Whalen and TD B0yer. Atlanta, GA Effect of e n d o t o x i n a n d i n f l a m m a t o r y c y t o k i n e s on b i l i r u b i n t r a n s p o r t i n r a t liver. (Abstract# L0452) J Nakamura, T Nishida, K Hayashi, E Hamada, T Ito, H Matsuda, H Ito and Y Sugiyama. Osaka and Tokyo, Japan D e p r e s s i o n of K u p f f e r cell f u n c t i o n a b o l i s h e s t h e r a p i d effect of L P S on t h e i n d o c y a n i n e - g r e e n u p t a k e - r a t e i n t h e liver. (Abstract# L0209) S Griine, M Michl, D Schinharl, G Rogler, E Frick, A H01stege and J Sch61merich. Regensburg, Germany R e g u l a t e d r e l e a s e of ATP f r o m h u m a n h e p a t o c y t e s p l a y s a k e y r o l e i n cell v o l u m e h o m e o s t a s i s . (Abstract# L0534) RM Roman, AP Feranchak, DK Guenette and JG Fitz. Denver, CO

R e g u l a t i o n of PKC-~ a n d PKC-~2 b y p h o r b o l e s t e r a n d bile acids i n c u l t u r e d h u m a n f i b r o b l a s t s . (Abstract# L0087) S Ceryak, M Le, GM Toso, H Fromrn and B Bouscarel. Washington, DC Inhibitory guanine nucleotide proteins regulate human hepatocellular carcinoma growth via a MAPK pathway. (Abstract# L0569) CM Schmidt, IH McKillop, PA Cahill and JV Sitzmann. Washington, DC M o l e c u l a r m e c h a n i s m s of p e r o x i s o m e p r o l i f e r a t i o n b y p e r o x i s o m e p r o l i f e r a t o r (Bezafibrate) in K u p f f e r cell. (Abstract# L0456) Y Nakamnra, H Yokoyama, D Ito, Y Kamegaya, Y Okamura, H Ohgo, M Matsum0t0, M Fukuda, T Mizukami, S Kat0 and H Ishii. Tokyo, Japan A role for p h o s p h o i n o s i t o l - 3 - k i n a s e in t h e s t i m u l a t i o n of h e p a t i c t a u r o c h o l a t e u p t a k e b y cyclic AMP. (Abstract# L0442) S Mukhopadhyay, CRL Webster, H Jameson and MS Anwer. Graft0n, MA Changes i n m e t h i o n i n e a d e n o s y l t r a n s f e r a s e d u r i n g liver r e g e n e r a t i o n i n t h e r a t . (Abstract# L0250) Z-Z Huang, Z Ma0, J Cai and SC Lu. Los Angeles, CA The r e g u l a t i o n of cyclin D - d e p e n d e n t k i n a s e a c t i v i t y in r e g e n e r a t i v e r a t liver f o l l o w i n g p a r t i a l h e p a t e c t o m y . (Abstract# L0293) A Kato, S Ota, H Bamba, A Adachi, S It0yama and F Matsuzaki. Saitama, Japan Differential [Ca2+]i s i g n a l l i n g i n e a r l y G1 a n d G1/S of cell-cycle i n r a t p r i m a r y c u l t u r e d h e p a t o c y t e s . (Abstract# L0323) T Kitamura, S Watanabe, M Hirose, T Yamada, K Ikejima, N Enom0to and N Sato. Tokyo, Japan O v e r e x p r e s s i o n of l i v e r g r o w t h i n h i b i t o r s is a s s o c i a t e d w i t h t h e g r o w t h a r r e s t of d i s e a s e d h e p a t o c y t e s i n t r a n s g e n i c mice. (Abstract# L0384) S L0caputo, M Grumpe and JA Bezerra. Cincinnati, OH and Portland, OR E p i m o r p h i n e x p r e s s e d i n h u m a n l i v e r s t e l l a t e cells is u p r e g u l a t e d b y t r a n s f o r m i n g g r o w t h factor-~. (Abstract# L0239) M Hir0se, S Watanabe, A Miyazaki, H Oide, T Kitamura, H Shimizu and N Sat0. Tokyo, Japan C o m p a r i s o n of h u m a n i n f a n t i l e d e v e l o p m e n t a l h e p a t i c stellate cell c h a n g e s w i t h l i v e r d i s e a s e s b y i m m u n o h i s t o c h e m i c a l s t u d y . (Abstract# L0614) T Sugitani, Y Matsuzaki, M Doy, Y Saito and N Tanaka. Ibaraki, Japan A l p h a l - a n t i t r y p s i n i n h i b i t s s e c r e t i o n of F a s l i g a n d i n h u m a n m o n o n c u l e a r cells b y affecting F a s l i g a n d processing. (Abstract# L0290) A Kaser and H Tilg. Innsbruck, Austria Induction of apoptosis after combined antioncogene a n d c y t o t o x i c t r e a t m e n t in c h e m o r e s i s t a n t h e p a t o c e l l u l a r c a r c i n o m a cells. (Abstract# L0197) JN Giannios, P Ginopoulos and JA Karagiannis. Athens and Patra, Greece C l i n i c o p a t h o l o g i c s i g n i f i c a n c e of c-myc g e n e a m p l i f i c a t i o n in h e p a t o c e l l u l a r c a r c i n o m a . (Abstract# L0298) S Kawate, T Fukusato, S Ohwada, I Takey0shi, Y Kawashima, T Ogawa, T Ohya, A Watanuki, K Kawashima, T Yamada, Y Nakasone, K Arai, M Aiba and Y Morishita. Maebashi, Japan

April 1998

PROGRAMOFTHEANNUALMEETINGPll AASLD

POSTER

SESSION

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SUNDAY,

MAY

17, 1998

H e t e r o g e n e i t y of cell r e n e w a l i n m o u s e liver [SH]thymidine a u t o r a d i o g r a p h i c investigation. (Abstract# L0329) S Kokuno, Y Magami, M Furukawa, Y Tsuki0ka, D Nakayama, T Azuma, H Inokuchi, K Kawai, T Hatt0ri and T Saitoh. Tokyo, Kyoto and Shiga, Japan

I n s u l i n i n h i b i t s s e c r e t i n - s t i m u l a t e d d u c t a l bile secretion i n bile d u c t l i g a t e d r a t s b y i n t e r a c t i o n w i t h i n s u l i n r e c e p t o r s o n cholangiocytes. (Abstract# L0367) G LeSage, S Glaser, A Caligiuri, J Phinizy, R Rodgers, H Francis, E Papa, J Lasater, W Robertson and G Alpini. Temple, TX

P a n c r e a t i c h e p a t o c y t e d i f f e r e n t i a t i o n i n the copperdeficient a d u l t r a t p a n c r e a s occurs via discrete p h e n o t y p i c a l l y - d e f i n a b l e stages. (Abstract# L0581) LB Shalon, TA Konkin, JA Bates and RA Fari8. Providence, RI

Ursodeoxycholate b u t n o t o t h e r cytoprotective bile acids r e d u c e s b i l i a r y a r a c h i d o n y l l e c i t h i n secretion, a n d t h e r e b y stabilizes a p h y s i c a l chemical state of bile lipids. (Abstract# L0427) H Miyake, S Tazuma, H Miura, Y Hattori, T Kajihara, T Nishioka, H Hyogo, Y Sunami, S Yasumiba, H Ochi, G Yamashita and G Kajiyama. Hiroshima, Japan

AASLD - - ALCOHOL AND BIOTRANSFORMATION

DDW Poster of Distinction: Polyunsaturated phosphatidylcholine incorporation i n t o p h o s p h o l i p i d s is g r e a t e r i n p a n c r e a s t h a n i n liver a n d p r o t e c t s a g a i n s t a l c o h o l - i n d u c e d oxidative stress i n both. (Abstract# L0015) SI Aleynik, MA Leo and CS Lieber. Bronx and New York, NY Hepatic stellate cells c o n t a i n fatty acid ethyl ester syuthase, a n e n z y m e t h a t c o n v e r t s e t h a n o l to lipophilic bioactive metabolites. (Abstract# L0372) JJ Li, PS Bora, S Chen, R O'Neill, BL Guruge, RS Britton and BR Bacon. St Louis, MO

Cytoprotection b y h y d r o p h i l i c bile salts: c o m p a r i s o n of changes i n b i l a y e r c a l c i u m p e r m e a b i l i t y , m e m b r a n e integrity, a n d p h o s p h a t i d y l c h o l i n e / c h o l e s t e r o l solubilization. (Abstract# L0153) JM Donovan and AA Jackson. Boston, MA T r a n s c y t o t i c vesicle f u s i o n w i t h c a n a l i c u l a r m e m b r a n e was r e d u c e d i n cholestatic rats: r e l a t i o n to r e d i s t r i b u t i o n of p h o s p h o l i p i d m o l e c u l a r species w i t h i n m e m b r a n e bilayer. (Abstract# L0251) H Hyogo, S Tazuma, G Yamashita, H Miura, T Kajihara, H Miyake, S Yasumiba, Y Sunami, Y Hattori, T Nishi0ka and G Kajiyama. Hiroshima, Japan

Kupffer cell d e r i v e d p r o s t a g l a n d i n E 2 is involved i n a l c o h o l - i n d u c e d f a t t y liver. (Abstract# L0163) N Enomot0, K Ikejima, BU Bradford, CA Rivera, GE Arteel, Z Zhong and RG Thurman. Chapel Hill, NC

A shift of l i p o p r o t e i n - b o u n d e n d o t o x i n i n bile d u c t ligated rats. (Abstract# L0579) ME Sewnath, JHM Levels, SJH van Deventer, MAW Maas, RPJ Oude Elferink, PR Abrahams and DJ Gouma. Amsterdam, The Netherlands

V o l t a g e d - d e p e n d e n t c a l c i u m c h a n n e l s i n stellate cells are u p r e g u l a t e d b y ethanol. (Abstract# L0269) T Itatsu, H Oide, M Hirose, A Miyazaki, S Watanabe, N Sat0, M Tateyama and R Ochi. Tokyo, Japan

C e n t r a l p r e s y n a p t i c s e r o t o n i n 5HT1A a u t o r e c e p t o r r e s p o n s i v e n e s s is e n h a n c e d i n cholestatic rats. (Abstract# L0620) MG Swain and T Le. Alberta, Canada

S e r u m h y a l u r o n a t e as a n e a r l y i n d i c a t o r for altered c o n n e c t i v e tissue t u r n o v e r i n alcoholic liver disease. (Abstract# L0515) G P6schl, A Strenge-Hesse, D Schuppan, F Stickel, UA Simanowski and HK Seitz. Heidelberg, Erlangen and Cologne, Germany

C o m p a r a t i v e e x p r e s s i o n a n d r e g u l a t i o n of PKC-a a n d PKC-~2 b y p h o r b o l ester i n h e p a t o c y t e s isolated from bile d u c t ligated a n d s h a m - o p e r a t e d h a m s t e r s . (Abstract# L0357) M Le and B Bouscarel. Washington, DC

Alcohol-induced d o w n r e g u l a t i o n of sex h o r m o n e r e s p o n s i v e p a r a m e t e r s i n a r a t model of liver disease. (Abstract# L0626) SD Tadic, MS Elm, VM Subbotin, RJ Steptoe and PK Eagon. Pittsburgh, PA Safety of b e t a i n e i n alcoholic hepatitis. (Abstract# L0243) S Holland, J Densmore, N N0v0tny and S Belknap. Peoria, IL The effect of liver disease i n m a n o n i n d i v i d u a l UDPg l u c u r o n o s y l t r a n s f e r a s e isoforms. (Abstract# L0248) ML Howard, ML Mashford and PV Desm0nd. Melbourne, Australia The effect of h o r m o n e s o n e x p r e s s i o n of UDPg l u c u r o n o s y l t r a n s f e r a s e i n c u l t u r e d r a t hepatocytes. (Abstract# L0374) YQ Li, SE D0cherty, DA Prentice, ML Howard, ML Mashford and PV Desmond. Melbourne, Australia AASLD - - BILIARY TRACT AND GALLSTONES

DDW Poster of Distinction: A d d i t i o n a l evidence for c h a n n e l - m e d i a t e d w a t e r t r a n s p o r t b y b i l i a r y epithelia. (Abstract# L0121) E Cova, R Marinelli and NF LaRusso. Rochester, MN

B o m b e s i n s t i m u l a t e s bile s e c r e t i o n i n calcium- a n d P K C - i n d e p e n d e n t p a t h w a y s . (Abstract# L0112) WK Cho, A Mennone and JL Boyer. Indianapolis, IN and New Haven, CT Isolation, expression a n d c h a r a c t e r i z a t i o n of a h u m a n ileal s o d i u m d e p e n d e n t bile acid t r a n s p o r t e r . (Abstract# L0049) F Behbod and D Loose-Mitchell. Houston, TX L e p t i n does n o t m e d i a t e t h e a n o r e x i a associated with b i l i a r y o b s t r u c t i o n i n rats. (Abstract# L0531) KP Rioux, PL Beck, AG Hoppin, T Le and MG Swain. Alberta, Canada and Boston, MA S u p p r e s s i o n of Kupffer cell s u p e r o x i d e r e l e a s i n g activity i n b i l i a r y o b s t r u c t i o n is due to toxic effects of h y d r o p h o b i c bile acids. (Abstract# L0617) JY Sung and MYY Go. Hong Kong, China Butyrate transport by rat liver canalicular membrane vesicles - p o t e n t i a l i m p l i c a t i o n s i n p r i m a r y sclerosing cholangitis. (Abstract# L0441) RH Moseley, A Berent and KL Snow. Ann Arbor, MI Evidence t h a t the b a c t e r i a l cell wall polymer, peptidoglycan-polysaccharide, plays a role i n p r i m a r y sclerosing cholangitis. (Abstract# L0376) SN Lichtman, A Bharucha, R Jorgensen and K Lindor. Chapel Hill, NC and Rochester, MN

II

P12 PROGRAM OF THE ANNUAL MEETING

Anti-neutrophil cytoplasmic antibodies in primary s c l e r o s i n g cholangitis: t a r g e t a n t i g e n s a n d clinical associations. (Abstract# L0535) C Ro0zendaal, AWM Van Milligen de Wit, EB Haagsma, G H0rst, C Schwarze, HH Peter, JH Kleibeuker, JWC Tervaert, PC Limburg and CGM Kallenberg. Groningen and Amsterdam, The Netherlands; Freiburg, Germany Bile d u c t p r o l i f e r a t i o n a n d b i l i a r y fibrosis associated w i t h a l t e r e d bile c o m p o s i t i o n i n a m o u s e m o d e l of e r y t h r o p o i e t i c p r o t o p h o r p h y r i a . (Abstract# L0416) L Meerman, NR K0open, V B10ks, H van Goor, R Havinga, M Mfiller, F Kuipers and PLM Jansen. Groningen, The Netherlands C h a r a c t e r i z a t i o n of the a n t i g e n for the a n t i n e u t r o p h i l cytoplasmic a n t i b o d y specific for p r i m a r y sclcrosing c h o l a n g i t i s / u l c e r a t i v e colitis. (Abstract# L0081) BJ Cameron, DS Bansi, R Ali, RW Chapman and KA Fleming. Oxford and London, United Kingdom aly/aly mice: a u n i q u e model for s p o n t a n e o u s i m m u n e m e d i a t e d b i l i a r y diseases. (Abstract# L0646) K Tsuneyama, ME Gershwin and Y Nakanuma. Kanazawa, Japan and Davis, CA F a m i l i a l i d i o p a t h i c a d u l t h o o d bile d u c t o p e n i a : a r e p o r t of five cases i n t h r e e g e n e r a t i o n s . (Abstract# L0078) K Burak, M Swain, D Pearson, J Kelly, S Urbanski and R Bridges. Calgary and Victoria, Canada

Multidrugresist~mce 2 gene e x p r e s s i o n i n the r o u t i n e liver: r e l e v a n c e to t h e d e v e l o p m e n t of p a r e n t e r a l n u t r i t i o n - a s s s o c i a t e d cholestasis. (Abstract# L0173) B Forbush, I Kiristioglu, DH Teitelbaum, MD Eisenbraun and KP Heidelberg. Ann Arbor, MI C o n j u g a t i o n w i t h t a u r i n e i n h i b i t s side-chain o x i d a t i o n of ~ m u r i c h o l a t e i n rats. (Abstract# L0212) M Guitaoui, C Aubert, AM Montet, R Infante and JC Montet. Marseille, France E i c o s a p e n t a e n o i c acid i n h i b i t s a r a c h i d o n i c acidinduced prostagrandin E2 synthesis and mucus g l y c o p r o t e i n s e c r e t i o n i n c u l t u r e d dog g a l l b l a d d e r e p i t h e l i a l cells. (Abstract# L0591) M Shimizu, M Abel, Y Matsuzaki, K Ikeda, J Shoda, N Tanaka, T Osuga and SP Lee. Ibaraki, Japan and Seattle, WA TNF-a s t i m u l a t e s m u c u s s e c r e t i o n i n g a l l b l a d d e r e p i t h e l i a l cells. (Abstract# L0107) CH Cheung, EW Moore, JB Prystowsky and RV Rege. Chicago, IL and Richmond, VA TNF-a s t i m u l a t e s m u c i n secretion, b u t n o t m u c i n synthesis, i n h u m a n g a l l b l a d d e r e p i t h e l i a l cells. (Abstract# L0160) MI Eder, DP Nunes, NH Afdhal and GD Offner. Boston, MA Effects of l o n g t e r m u r s o d e o x y c h o l a t e a d m i n i s t r a t i o n o n e x p r e s s i o n levels of secretory low m o l e c u l a r weight p h o s p h o l i p a s e s A2 a n d m u c i n genes i n p a t i e n t s with m u l t i p l e cholesterol stones. (Abstract# L0286) M Kano, J Shoda, T Ueda, R Iwasaki, T Irimura, T Urasaki, Y Kawauchi, T Asano, Y Matsuzaki and N Tanaka. Ibaraki and Tokyo, Japan Effects of e i c o s a p e n t a e n o i c acid o n b i l i a r y lipids a n d gallstone f o r m a t i o n i n cholesterol fed h a m s t e r s : c o m p a r i s o n w i t h o t h e r f a t t y acids. (Abstract# L0001) M Abei, H Kawano, T Yano, K Mizuguchi, J Shoda, Y Matsuzaki, N Tanaka and T Osuga. Ibaraki and Shizuoka, Japan

G A S T R O E N T E R O L O G Y Vol. U 4 t No. 4

A role of p h o s p h o l i p a s e A2 i n cholesterol gallstone p a t h o g e n e s i s is asociated with b i l i a r y p h o s p h o l i p i d species s u b s e l e c t i o n at t h e site of h e p a t i c excretion. (Abstract# L0224) Y Hattori, S Tazuma, G Yamashita, Y Sunami, S Yasumiba, H Hyogo, T Nishioka, H Miyake, H Miura, T Kajihara, H Ochi and G Kajiyama. Hiroshima, Japan E n h a n c e d expression of secretory low m o l e c u l a r weight phospholipases A 2 a n d a l t e r e d e x p r e s s i o n of m u c i n genes i n affected i n t r a h e p a t i c bile ducts with hepatolithiasis. (Abstract# L0031) T Asano, M Kan0, J Shoda, T Ueda, R Iwasaki, T Irimura, T Urasaki, Y Kawauchi, Y Matsuzaki and N Tanaka. Ibaraki and Tokyo, Japan E v i d e n c e for the role of A m e r i n d i a n a n c e s t r y as a r i s k factor for cholesterol gallstone disease i n Chile. (Abstract# L0426) JF Miquel, C Covarrubias, AV Grec0, L Puglielli, P Carvallo, G Marshall, G Del-Pino and F Nervi. Rome, Italy and Santiago, Chile P a r t i a l r e p l a c e m e n t of bile salts causes d r a s t i c a l t e r a t i o n i n bile m e t a s t a b i l i t y i n s u p e r s a t u r a t e d m o d e l bile systems: r e l a t i o n to bile salt micelle-forming capacity. (Abstract# L0465) T Nishioka, S Tazuma, Y Sunami, S Yasumiba, H Hyogo, H Miyake, Y Hattori, H Miura, G Yamashita and G Kajiyama. Hiroshima, Japan Bile leak following laparoscopic cholecystectomy: m a n a g e m e n t i n a c o m m u n i t y hospital. (Abstract# G2124) GR Gambla and B Warren. Hershey, PA and Farmingt0n Hills, MI Day care or h o s p i t a l a d m i s s i o n after l a p a r o s c o p i c cholecystectomy: a prospective r a n d o m i z e d trial. (Abstract# L0302) YCA Keulemans, JH Eshuis, JCJM De Haes, A Leeuwenberg, LT Wit and DJ Gouma. Amsterdam, The Netherlands Balloon s p h i n c t e r o p l a s t y a n d d e l a y e d cholecystectomy: w h a t is the r i s k for r e c u r r e n t b i l i a r y o b s t r u c t i o n ? (Abstract# G2168) J Meenan, R Ede, PJ Ciclitira and RPH Thompson. London, United Kingdom The e s t i m a t i o n of c o m m o n bile d u c t s t o n e r e s i d u e s r e s i s t a n t to e x t r a c o r p o r e a l shock wave lithotripsy. (Abstract# G2184) T Ohya, M Murakami, H Kai, H Shirakawa, K Tamaki, T Suenaga, K Masuda, K Okamoto and A Maruhashi. Hiroshima, Japan Hepatolithiasis associated w i t h Caroli's disease is f r e q u e n t l y of the cholesterol subtype. (Abstract# L0433) G Montalto, F Cetta, M Zuckermann, D Cetta, C Baldi, P Piro, G Nuzzo and Y Nimura. Siena and Rome, Italy; Nagoya, Japan AASLD - - VIRAL H E P A T I T I S C: T R E A T M E N T

D D W Poster of Distinction: A r a n d o m i z e d c o n t r o l l e d t r i a l of d a i l y v e r s u s t h r e e times weekly i n t e r f e r o n - a 2 a i n p a t i e n t s w i t h c h r o n i c HCV a n d either elevated or p e r s i s t e n t l y n o r m a l ALT. (Abstract# L0605) CA Stewart, CM H0fmann, VA Luketic, AJ Sanyal, RK Sterling and ML Shiffman. Richmond, VA

PROGRAMOFTHEANNUALMEETINGP13

April 1998

II

A A S L D P O S T E R S E S S I O N m S U N D A Y , MAY 17, 1998

DDW Poster of Distinction: High dose i n d u c t i o n t h e r a p y w i t h a l p h a i n t e r f e r o n is effective i n p a t i e n t s w i t h h i g h h e p a t i t i s C v i r a l load. (Abstract# L0201) HJ Gonzalez, SB Ho, JB Gross, C Peine, D McKee, T Smith and the Midwest Hepatitis Study Group. Minneapolis, MN

DDW Poster of Distinction: Daily h i g h . d o s e i n t e r f e r o n s u p p r e s s e s v i r e m i a i n patients with chronic hepatitis C without a previous s u s t a i n e d r e s p o n s e to s t a n d a r d t r e a t m e n t . (Abstract# L0206) JB Gross, DJ Brandhagen, JJ Poterucha, AA Gossard, DD Douglas and the Midwest Hepatitis Study Group. Rochester, MN High-dose i n d u c t i o n w i t h i n t e r f e r o n - a 2 b is safe a n d efficacious i n i n t e r f e r o n r e l a p s e r s a n d n o n - r e s p o n d e r s w i t h c h r o n i c h e p a t i t i s C. (Abstract# L0188) D Ganger, H Conjeevaram, T Wiley, S Flamm and K O'Riordan. Chicago, IL R e d u c e d s e n s i t i v i t y of HCV genotype 3 to a i n t e r f e r o n 2b (INTRON A) w h e n co-infected w i t h genotype 1. (Abstract# IA)471) DP Nunes, GD Offner and NH Afdhal. Boston, MA Effects of a o n e - y e a r i n t e r f e r o n - a t h e r a p y o n body c o m p o s i t i o n i n p a t i e n t s w i t h c h r o n i c h e p a t i t i s C. (Abstract# L0510) T Fiche, S Schneider, S H~buterne, G Dreyfus, A Tran and P Rampal. Nice, France With h i g h dose n a t u r a l i n t e r f e r o n - a t r e a t m e n t , p r e d i c t i o n of the t h e r a p y for p a t i e n t s w i t h c h r o n i c h e p a t i t i s C: i n 215 cases, the m u l t i v a r i a t e analysis of c h a r a c t e r i s t i c s b e t w e e n p a t i e n t s a n d h e p a t i t i s C virus. (Abstract# L0407) Y Matsuzaki, N Tanaka, H Takagi, M Mori, Y Oka and K Nakajhima. Tsukuba, Maebashi, Hitachi and Ohmiya, Japan P r e d i c t i o n of r e s p o n s e to r e t r e a t m e n t w i t h interferona2b i n c h r o n i c h e p a t i t i s C p a t i e n t s who p r e v i o u s l y failed 24 weeks of i n t e r f e r o n - a t h e r a p y . (Abstract# L0644) M Tong, LM Blatt, L Tong, K Sayadzadeh and A Conrad. Pasadena and Los Angeles, CA

DDW Poster of Distinction: Differences i n v i r a l k i n e t i c s b e t w e e n HCV genotype 1 v e r s u s 2 or 3 m a y e x p l a i n differences i n t r e a t m e n t r e s p o n s e . (Abstract# L0347) NP Lain, AU Neumann, AS Perelson, DR Gretch, TE Wiley and TJ Layden. Chicago, IL; Israel; Los Alamos, NM and Seattle, WA B i p h a s i c v i r a l c l e a r a n c e of HCV genotype I d u r i n g h i g h dose IFN i n d u c t i o n t r e a t m e n t . (Abstract# L0346) NP Lain, AU Neumann, AS Perelson, DR Gretch, TE Wiley and TJ Layden. Chicago, IL; Israel; Los Alamos, NM and Seattle, WA E x p r e s s i o n of i n t e r f e r o n r e c e p t o r genes i n the liver as a p r e d i c t o r of i n t e r f e r o n r e s p o n s e i n p a t i e n t s w i t h c h r o n i c h e p a t i t i s C v i r u s infection. (Abstract# L0438) K Morita, K Tanaka, S Saito, T Kitamura, M Kondo, T Sakaguchi, M Morimoto, T Kiba, K Numata, H Okazaki and H Sekihara. Yokohama, Japan

S u s t a i n e d virologic r e s p o n s e to i n t e r f e r o n - ~ i n c h r o n i c h e p a t i t i s C is associated w i t h l o n g t e r m histologic i m p r o v e m e n t a n d lack of h e p a t i c HCV RNA. (Abstract# L0353) DT-Y Lau, DE Kleiner, MG Ghany, P Schmid and JH Hoofnagle. Bethesda, MD and Los Angeles, CA Prospective s t u d y of i n t e r f e r o n t h e r a p y for c o m p e n s a t e d cirrhotic p a t i e n t s w i t h c h r o n i c h e p a t i t i s C b y m o n i t o r i n g s e r u m h e p a t i t i s C v i r u s RNA. (Abstract# L0595) Y Shiratori, O Yokosuka, R Nakata, M Ihori, K Hirota, T Katamoto, T Unuma, K Okano, Y Ikeda, M Hirano, Y Ohashi and M Omata. Tokyo, Japan Sustained alanineaminotransferasenormalization r e g a r d l e s s of v i r u s e r a d i c a t i o n is associated with longl a s t i n g histologic i m p r o v e m e n t i n c h r o n i c h e p a t i t i s C p a t i e n t s t r e a t e d w i t h i n t e r f e r o n - a . (Abstract# L0076) S Bruno, A Manzin, G BeUati, A Crosignani, M Maggioni, L Solforosi, S Rossi, MO Pedicino, M Clementi, G Id~o and M Podda. Milan, Italy F o u r - y e a r follow-up of t h e s e r u m fibrogenesis m a r k e r s i n t h e p a t i e n t s with c h r o n i c h e p a t i t i s type C after interferon therapy; comparison between responders a n d n o n - r e s p o n d e r s . (Abstract# L0264) K Ishibashi, T Kashiwagi, T Yokoi, S Maeyama, Y Isoo, M Nagasawa, Y Ito, M Naito, K Katayama and M Azuma. Osaka, Japan P r e d i c t i v e value of the t i m i n g of ALT a n d HCV RNA r e s p o n s e s i n d e f i n i n g p a t i e n t s who will h a v e a virologic s u s t a i n e d r e s p o n s e after six m o n t h s of i n t e r f e r o n therapy. (Abstract# L0301) E Keeffe, C Smith, K Lyche and the CIFN Study Group. Palo Alto and San Diego, CA; Minneapolis, MN I n t e r f e r o n a n d HCV v i r a l l o a d - a t i m e to redefine " t r e a t m e n t failure". (Abstract# L0345) G Lake-Bakaar. Stony Brook, NY

DDW Poster of Distinction: Economic analysis of i n t e r f e r o n / r i b a v i r i n t r e a t m e n t i n p a t i e n t s w i t h c h r o n i c h e p a t i t i s C who r e l a p s e following i n i t i a l i n t e r f e r o n t h e r a p y . (Abstract# L0314) WR Kim, JJ Poterucha, ER Dickson and JB Gross. Rochester, MN

DDW Poster of Distinction: P r e l i m i n a r y r e s u l t s of t h e NYNEST i n t e r f e r o n - r i b a v i r i n r e - t r e a t m e n t t r i a l i n n o n - r e s p o n d e r s a n d relapsers w i t h c h r o n i c h e p a t i t i s C. (Abstract# L0337) EL Krawitt, R Albertini, A John, M Kaplan, S Moskowitz, L Schapira, A Kilby, L Antignano, H Malam0od, W Notis, R Cimis, S Gordon, Y Maheshwari, M Brand, G Wu, J Yarze and C Brass. Forest Hills, Rochester, Albany and Glens Falls, NY; Portland, ME; Lebanon, NH; New Haven and Farmington, CT; Kenilworth, NJ I n t e r f e r o n - a 2 b plus r i b a v i r i n for t h e t r e a t m e n t of chronic hepatitis C in prior interferon non-responders: i n t e r i m r e s u l t s of a c o m m u n i t y trial. (Abstract# L0370) JH Lewis, JE Gallagher, L Gibbs and ME Epstein. Washington, DC Pilot s t u d y of i n t r o n - A a n d r i b a v i r i n v e r s u s i n t r o n - A a n d a m a n t a d i n e i n i n t e r f e r o n n o n - r e s p o n d e r s with c h r o n i c h e p a t i t i s C. (Abstract# L0303) M Khalili, M Olmeda, VA Yantsos and RP Perrillo. New Orleans, LA

P14 P R O G R A M O F T H E A N N U A L M E E T I N G

Effect of i n i t i a l i n t e r f e r o n d o s i n g a n d dose o n early r e s p o n s e to c o m b i n a t i o n t h e r a p y w i t h r i b a v i r i n i n c h r o n i c h e p a t i t i s C. (Abstract# L0169) P Ferenci, P Steindl, C Datz, W Lin and W Vogel. Vienna and Innsbruck, Austria Combination therapy with ribavirin pins alpha i n t e r f e r o n for t h e t r e a t m e n t of c h r o n i c h e p a t i t i s s e c o n d a r y to h e p a t i t i s C v i r u s i n p a t i e n t s who have failed t r e a t m e n t w i t h a l p h a i n t e r f e r o n . (Abstract# L0344) PY Kwo, DC Pound, S Fields, EA Glowinski, L Born, N Chalasani, W Cho, DW Crabb, OW Cummings, T Imperiale, L Lumeng, J McGill and R Ness. Indianapolis, IN A n o p e n label t r i a l of r i m a n t a d i n e for t r e a t m e n t of p a t i e n t s who h a v e failed or a r e u n a b l e to tolerate i n t e r f e r o n t h e r a p y for h e p a t i t i s C. (Abstract# L0343) PY Kwo, S Fields, L Born, N Chalasani, W Cho, DW Crabb, OW Cummings, T Imperiale, L Lumeng, J McGill and R Ness. Indianapolis, IN S e q u e n t i a l v e r s u s c o n c o m i t a n t a d m i n i s t r a t i o n of ribavirin and interferon-an3 in patients with chronic h e p a t i t i s C n o t r e s p o n d i n g to i n t e r f e r o n alone. Results of a r a n d o m i z e d c o n t r o l l e d trial. (Abstract# L0600) R Sostegni, V Ghisetti, F Pittaluga, G Marchiaro, G Rocca, E Borghesio, M Rizzetto and G Saracco. Turin, Italy The effect of c o m b i n a t i o n t h e r a p y ( i n t e r f e r o n a n d r i b a v i r i n ) o n p e r i p h e r a l blood l y m p h o c y t e a n d leukocyte c o u n t s . (Abstract# L0068) OS Brann and JG McHutchison. La Jolla, CA E a r l y h e p a t i t i s C v i r a l RNA d e c l i n e d u r i n g t h e r a p y w i t h i n t e r f e r o n - a 2 b a n d r i b a v i r i n i n p a t i e n t s with c h r o n i c h e p a t i t i s C w i t h o u t s u s t a i n e d r e s p o n s e to p r i o r i n t e r f e r o n . (Abstract# L0423) A Min, J Jones, S Esposito, E Lebovics, F Klion, I Jacobson, I Goldman, J Geders, H Tobias, A Branch and H Bodenheimer, Jr. New York, NY R e t r e a t m e n t w i t h r i b a v i r i n a n d interferon-~2b of r e l a p s e r s a n d n o n - r e s p o n d e r s to m o n o t h e r a p y . (Abstract# L0444) S Munoz, A Suvannasankha, K DiGregorio, L Stein, F Gross, S Peikin, O Perez, G Benson, A Mushnick, C DeAngelo, J Goldfarb, K Rothstein, N Kern and D Fleischer. Philadelphia, PA; Flemington, West Orange, Oakhurst, Camden, Voorhees and Fort Lee, NJ; Allentown, Philadelphia and Pottstown, PA Baseline h a p t o g l o b i n : is it a p r e d i c t o r for severity of hemolysis d u r i n g r i b a v i r i n a n d i n t e r f e r o n c o m b i n a t i o n t h e r a p y for c h r o n i c h e p a t i t i s C? (Abstract# L0548) GS Sandha, KM Peltekian, D Dickey and CN Williams. Halifax, Canada

DDW Poster of Distinction: A m a n t i d i n e is n o t effective i n c l e a r i n g HCV from the s e r u m i n p a t i e n t s who are n o t c a n d i d a t e s for i n t e r f e r o n t h e r a p y . (Abstract# L0686) TE Wiley, M Mihalov, K O'Riordan, TJ Layden and NP Lain. Chicago and Park Ridge, IL Amantidine monotherapy in patients with chronic h e p a t i t i s C. (Abstract# L0484) M Olmeda, M Khalili and RP Perrillo. New Orleans, LA I n s u l i n - d e p e n d e n t diabetes m e l l i t u s d u e to i n t e r f e r o n a2a t h e r a p y for c h r o n i c v i r a l h e p a t i t i s C. (Abstract# L0192) M Gatzen, BJ Manfras, U Wiest, W Richter, C L61iger, P K~ihnl, P vanEndert, J Pausch and BO Boehm. Kassel, Ulm and Hamburg, Germany; Paris, France

G A S T R O E N T E R O L O G Y VoL 114~ No. 4

R e s o l u t i o n of acute h e p a t i t i s C i n A s i a n I n d i a n s after a l p h a i n t e r f e r o n t h e r a p y : p r e l i m i n a r y r e p o r t of a c o n t r o l l e d trial. (Abstract# L0213) RC Guptan, V Thakur and SK Satin. New Delhi, India One y e a r i n t e r f e r o n - a 2 a t h e r a p y i n h e m o d i a l y s e d p a t i e n t s with c h r o n i c h e p a t i t i s C. (Abstract# L0355) S Lavaud, C Hanrotel, V Brodard, O Toupance, MD Diebold, D Ingrand, G Thi~fm and J Chanard. Reims, France V i t a m i n E i n t r e a t m e n t of h e p a t i t i s C r e s i s t a n t to a l p h a i n t e r f e r o n : a r a n d o m i z e d , double-blinded, placeboc o n t r o l l e d pilot study. (Abstract# L0463) MT Nguyen, RA Rubin and MA Zern. Philadelphia, PA C h r o n i c HBV/HCV h e p a t i t i s i n h e a r t t r a n s p l a n t recipients: open a-IFN t r e a t m e n t . (Abstract# L0425) F Minniti, S Pevere, A Graziotto, P Burra, A Buda, M Chiaramonte, U Livi, R Naccarate and S Fagiuoli. Padua, Italy S u s t a i n e d r e s p o n s e r a t e s of c h r o n i c h e p a t i t i s C p a t i e n t s t r e a t e d w i t h i n t e r f e r o n a l p h a w i t h doses t a i l o r e d to p r e - t r e a t m e n t HCV RNA levels: a prospective r a n d o m i z e d pilot s t u d y . (Abstract# L0177) BL Freilich, JB Eisenach, J Raines, L Jackson, T VanOmmeren and K Cornish. Kansas City, MO Q u a l i t y of life i n p a t i e n t s with c h r o n i c h e p a t i t i s C d u r i n g high dose i n d u c t i o n i n t e r f e r o n t r e a t m e n t . (Abstract# L0093) JW Cha, TJ Layden and NP Lain. Chicago, IL Viral k i n e t i c s t u d y of i n d u c t i o n d o s i n g w i t h i n t e r f e r o n a a n d r i b a v i r i n i n t h e t r e a t m e n t of c h r o n i c h e p a t i t i s C. (Abstract# L0666) B Vucelic, R Ostojic, I Hrstic, B Grahovac and M ScukanecSpoljar. Zagreb, Croatia The epidemiology a n d r e s p o n s e to t r e a t m e n t o f h e p a t i t i s C i n n o n - h e m o p h i l i a c p a t i e n t s r e f e r r e d to liver clinic i n N o r t h e r n I r e l a n d . (Abstract# L0413) NI McDougall, PV Coyle and ME Callender. Belfast, Northern Ireland

a

I m p a c t of p s y c h i a t r i c disorders o n t r e a t m e n t of p a t i e n t s w i t h h e p a t i t i s C. (Abstract# L0392) P Lynch, M Peters, M Quigley, J Sreenarasaimhiah and C Ca]dwell. St Louis, MO D i s t r i b u t i o n of a m i n o acid m u t a t i o n s i n t h e NS5A r e g i o n a n d i n t e r f e r o n s e n s i t i v i t y i n c h r o n i c h e p a t i t i s C. (Abstract# L0676) H Watanabe, N Enomoto, N Izumi, M Shirnizu, O Noguchi, Y Hoshino, M Uchihara, S Miyake, T Sakai, F Marumo and C Sate. Tokyo, Japan The epidemiology, t r e a t m e n t p a t t e r n s a n d r e s o u r c e u t i l i z a t i o n of h e p a t i t i s C p a t i e n t s i n a large i n s u r e d N e w E n g l a n d p o p u l a t i o n . (Abstract# L0538) DM Rosenberg, SF Cook, SC Eaton, WB Saunders and LL Lanza. Research Triangle Park, NC and Newton Lower Falls, MA AASLD - - VIRAL H E P A T I T I S B AND O T H E R VIRAL HEPATITIS

DDW Poster of Distinction: Different HBV genotypes are associated w i t h different m u t a t i o n s i n the core p r o m o t e r a n d p r e c o r e r e g i o n s d u r i n g HBeAg seroconversion. (Abstract# L0097) HLY Chan, M Hussain and ASF Lok. Ann Arbor, MI

PROGRAM OF THE ANNUAL MEETING P15

April 1998

A A S L D P O S T E R S E S S I O N m S U N D A Y , MAY 17, 1998 D i s a p p e a r a n c e of HBcAG i n t h e l i v e r is a c l i n i c a l l y u s e f u l m a r k e r f o r d i s c o n t i n u a t i o n of l a m i v u d i n e t h e r a p y i n p a t i e n t s w i t h c h r o n i c h e p a t i t i s B. (Abstract# L0675) H Watanabe, N Izumi, M Simizu, 0 Noguchi, Y Hoshino, M Uchihara, S Miyake, T Sakai, N Enomoto and C Sato. Tokyo, Japan The e p i d e m i o l o g y , t r e a t m e n t p a t t e r n s a n d r e s o u r c e u t i l i z a t i o n of h e p a t i t i s B p a t i e n t s i n a l a r g e i n s u r e d N e w E n g l a n d p o p u l a t i o n . (Abstract# L0537) DM Rosenberg, SF Cook, SC Eaton, WB Saunders and LL Lanza. Research Triangle Park, NC and Newton Lower Falls, MA Clinical s i g n i f i c a n c e of HBV c o r e gene m u t a t i o n s i n a c u t e v i r a l h e p a t i t i s B. (Abstract# L0316) YS Kim, SJ Hong, JH Moon, YD Cho, JO Kim, JY Cho, JS Lee, MS Lee, SG Hwang and CS Shim. Seoul, Korea P r e c o r e m u t a t i o n of h e p a t i t i s B v i r u s i n HBe a n t i g e n positive chronic hepatitis B in association with r e s p o n s e to i n t e r f e r o n - a l p h a . (Abstract# L0183) K Fujimoto, M Kate, A Kaneko, K Yamamot0, K Kurosawa, M Masuzawa, A Kasahara and N Hayashi. Osaka, Japan M u t a t i o n s w i t h i n h e p a t o c y t e n u c l e a r factor-4 b i n d i n g site e x h i b i t p o o r r e s p o n s e to i n t e r f e r o n t h e r a p y i n p a t i e n t s w i t h t y p e B c h r o n i c h e p a t i t i s . (Abstract# L0292) K Katayama, N Hayashi, A Omae, K Ohkawa, K Ueda, K Mochizuki, Y Sasaki, A Kasahara, T Nagaoka, T Yamauchi and M Hori. Osaka, Japan A n t i b o d y b i n d i n g o f v a r i o u s r o u t i n e anti-HBs a n t i b o d i e s t o n a t u r a l l y a p p e a r i n g HBsAg m u t a n t s . ( A b s t r a c t # L0119) MP Cooreman, MH van Reosmalen, R Te Morsche, CMG S~innen, E Schoondermark-Van De Ven and WP Paulij. Amsterdam, Nijmegen and Boxtel, The Netherlands In ~ v o a n d in ~ t r o a n a l y s i s of v a c c i n e - i n d u c e d e s c a p e m u t a n t of h e p a t i t i s B virus. (Abstract# L0596) T Shizuma, K Hasegawa, N Torii, K Ishikawa, T Naritomi, A Iizuka, K Yamauchi and N Hayashi. Tokyo, Japan

DDW Poster of Distinction: The p r e n y l a t i o n i n h i b i t o r BZA-SB p r e v e n t s v i r u s p a r t i c l e assembly. ( A b s t r a c t # L0198) JS Glenn, JC Marsters, Jr and HB Greenberg. Palo Alto, CA H e p a t i t i s G v i r u s i n f e c t i o n in b l o o d d o n o r s w i t h positive screening test for hepatitis C virus antibody. (Abstract# L0630) D Tan, A Matsumoto, C Conry-Cantilena, JC Melpolder, G Hess, M Leuther, JWK Shih and HJ Alter. Bethesda, MD and Mannheim, Germany The r o l e of GBV-C/HGV i n f u l m i n a n t h e p a t i c failure. (Abstract# L0629) Y Takikawa, K Suzuki, R Endo, M Iwai, K Abe, K Ishikawa and S Sato. Morioka, Japan H e p a t i t i s G v i r u s i n f e c t i o n in a n t i - H I V p o s i t i v e p a t i e n t s . (Abstract# L0387) F Longo, A Tran, J Durant, P Halfon, T Manos, G Yang, D Ouzan, P DeUamonica, S Benzaken and P Rampal. Nice and Marseille, France The histological i m p a c t of h e p a t i t i s G Virus on alcoholr e l a t e d l i v e r disease. (Abstract# L0388) F Longo, A Tran, P Hastier, G Yang, A Doglio, D Ouzan, R Follana, MC Saint-Paul, M Buckley, P Rampal and S Benzaken. Nice and St Laurent-Du-Var, France P r e v a l e n c e of h e p a t i t i s C a n d h e p a t i t i s G in alcoholics a t a n i n p a t i e n t a l c o h o l i s m r e c o v e r y facility. (Abstract# L0227) MF Heberle, KC Holtzmuller, JM Bednarek, SK Okada, WB Batzer and MH Sjogren. Washington, DC Cost-effective a n a l y s i s of d i f f e r e n t s t r a t e g i e s of hepatitis A vaccination in adults - a Markov model a n a l y s i s . (Abstract# L0133) A Das. Cleveland, OH Low-dose, non-toxic IL-2 t h e r a p y is effective i n t h e t r e a t m e n t of HIV/HBV a n d HIV/HCV coinfection. (Abstract# L0566) J F Schlaak, K Radecke, K-H Meyer zum Biischenfelde and G Gerken. Mainz, Germany

S e q u e n c e a n a l y s i s of t h e p r e - S r e g i o n i n s e v e r e h e p a t i t i s p a t i e n t s w i t h a n a c c u m u l a t i o n of HBV e n v e l o p e p r o t e i n i n h e p a t o c y t e . (Abstract# L0257) A Iizuki, K Hasegawa, K Ishikawa, T Shizuma, T Naritomi, N Torii, K Yamauchi and N Hayashi. Tokyo, Japan

Molecular epidemiology of hepatitis D virus genome i s o l a t e d from a n i s l a n d (Miyako I s l a n d ) in J a p a n . (Abstract# L0440) M Moriyama, Y Arakawa, M Taira, N Hayashi, H Matsumura, T Segawa, H Iwasaki, S Ichijima, K Iwaguchi, A Kasuya and Y Arakawa. Tokyo, Japan

Hepatitis virus markers in the northwestern Greece b l o o d d o n o r p o p u l a t i o n . C o r r e l a t i o n b e t w e e n anti-HBc a n d HBV v i r e m i a . (Abstract# L0711) E Zervou, GN Dalekos, D Boumba and EV Tsianos. Ioannina, Greece

C o s t i m u l a t o r y effects of IL-12 o n HBV-induced i m m u n e r e s p o n s e a r e s u p p r e s s e d in p a t i e n t s w i t h a h i g h v i r a l load. (Abstract# L0565) J F Schlaak, G Tully, HF L6hr, G Gerken and KH Meyer zum Biischenfelde. Mainz, Germany

O u t c o m e i n p a t i e n t s w i t h a c u t e h e p a t i t i s B: is t h e r e a r e l a t i o n s h i p w i t h t h e i n t e r f e r o n - i n d u c e d 2'5" o l i g o a d e n y l a t e s y n t h e t a s e activity? (Abstract# L0113) S Chousterman, CM Lu, P Kernevez, H Zylberberg, J Haddad, H Hag~ge and M Chousterman. Creteil, France

P e r s i s t e n t l i v e r d y s f u n c t i o n in c h i l d r e n a s s o c i a t e d w i t h human herpesvirus-6 infection - clinical features and in Mtu h y b r i d i z a t i o n s t u d y . (Abstract# L0492) Y Ozaki, H Tajiri, S Mushiake, K Tada and S Okada. Osaka, Japan

D D W Poster of Distinction: H e p a t i t i s G v i r u s c a n r e p l i c a t e i n t h e liver. (Abstract# L0543) S Saito, K Tanaka, M Ikeda, M Kondo, K Morita, T Kitamura, T Sakaguchi, M Morimoto, T Kiba, K Numata, H Okazaki, N Kato and H Sekihara. Yokohama and Tokyo, Japan

Chronic cytomegalovirus hepatitis in three i m m u n o c o m p e t e n t i n f a n t s - i n situ h y b r i d i z a t i o n s t u d y a n d g a n c y c l o v i r t h e r a p y . (Abstract# L0624) K Tada, H Tajiri, K Kozaiwa, S Mushiake, A Sawada, S Okada and M Nakayama. Osaka, Japan Hepatopulmonary syndrome in chronic viral hepatitis. (Abstract# L0637) G Teuber, C Teupe, C-F Dietrich, W-F Caspary, R Buhl and S Zeuzem. Frankfurt, Germany

GASTROENTEROLOGYVoL114~No.4

P16PROGRAMOFTHEANNUALMEETING I[

AASLD

POSTER

SESSION

AASLD -- CHRONIC CHOLESTATIC AND AUTOIMMUNE LIVER DISEASE U t i l i t y of H e a l t h S t a t u s Q u e s t i o n n a i r e (SF-36) in t h e a s s e s s m e n t of h e a l t h s t a t u s i n p a t i e n t s w i t h c h o l e s t a t i c l i v e r disease. (Abstract# L0396) M Malinchoc, WR Kim, KD Lindor, RA Jorgensen, JL Petz and ER Dickson. Rochester, MN P r o f o u n d r e d u c t i o n i n h e a l t h - r e l a t e d q u a l i t y of life in p a t i e n t s w i t h c h r o n i c l i v e r disease. (Abstract# L0705) ZM Younossi, ML Kiwi, M Secic and G Guyatt. Columbus, OH and Hamilton, Canada

DDW Poster of Distinction: P a r t i a l i n h i b i t i o n of u r s o d e o y h o l i c a c i d m e d i a t e d a c t i v a t i o n of t h e g l u c o c o r t i c o i d r e c e p t o r b y t h e GRantagonist RU486. (Abstract# L0679) C Weitzel, D Stark and J SchSlmerich. Regensburg, Germany Long term ursodeoxycholic acid therapy delays histologic progression in primary biliary cirrhosis. (Abstract# L0021) P Angulo, KP Batts, TM Therneau, RA Jorgensen, ER Dickson and KD Lindor. Rochester, MN D e t e r m i n i n g t h e m o s t efficacious d o s e of ursodeoxycholic acid in primary biliary cirrhosis. (Abstract# L0662) A Verma, RP Jazrawi, HA Ahmed, T Davis, M Bland, M Benson, RT Orchard, A Theodossi, JD Maxwell and TC Northfield. London, United Kingdom Causes of m o r t a l i t y i n p a t i e n t s w i t h p r i m a r y b i l i a r y c i r r h o s i s t r e a t e d w i t h u r s o d i o l . (Abstract# L0381) KD Lindor, J Petz, EJ Heathcote, 0 Chazouill~res, K CauehDudek, RE Poupon and R Poupon. Rochester, MN; Toronto, Canada; Paris and Villejuif, France A n t i o x i d a n t t h e r a p y for t h e s y m p t o m a t i c t r e a t m e n t of p r i m a r y b i l i a r y c i r r h o s i s : a p i l o t s t u d y . (Abstract# L0677) JP Watson, PA Cann, MG Bramble, OFW James and DEJ Jones. Middlesbrough and Newcastle upon Tyne, United Kingdom T h e p r e s e n t a t i o n of p r i m a r y b i l i a r y c i r r h o s i s i n t h e elderly. (Abstract# L0462) JL Newton, DEJ Jones, JV Metcalf, AD Butt, MF Bassendine and OFW James. Newcastle, United Kingdom S u p p r e s s i o n of PBC-like h e p a t i c lesions i n m u r i n e GVHR m o d e l b y a n t i b o d i e s a g a i n s t a d h e s i o n molecules. (Abstract# L0271) S Itoh, Y Matsuzaki, T Kimura, T Ikegami, J Shoda and N Tanaka. Ibaraki, Japan I n t e r l e u k i n - 1 0 -592 p r o m o t e r p o l y m o r p h i s m a n d p r i m a r y b i l i a r y c i r r h o s i s : no a s s o c i a t i o n w i t h d i s e a s e s u s c e p t i b i l i t y o r s e v e r i t y . (Abstract# L0709) F Zappala, J Grove, FE Watt, AK Daly, CP Day, MF Bassendine and DEJ Jones. Newcastle upon Tyne, United Kingdom Is a u t o i m m u n e c h o l a n g i t i s d i f f e r e n t f r o m p r i m a r y b i l i a r y c i r r h o s i s o r n o t ? T h e n e c e s s i t y of anti-M2 a n t i b o d y d e t e c t i o n b y i m m u n o b l o t t i n g w i t h each of IgG, IgA a n d IgM i m m u n o g l o b u l i n s u b c l a s s in PBC sera. (Abstract# L0450) M Nakajima, H Shimizu, S Watanabe, A Miyazaki and N Sato. Tokyo, Japan

-- SUNDAY,

MAY

17, 1998

F r e q u e n c y a n d s i g n i f i c a n c e of a l p h a 1 a n t i t r y p s i n d e f i c i e n c y i n t y p e 1 a u t o i m m u n e h e p a t i t i s . (Abstract# L0125) AJ Czaja. Rochester, MN P a t h o g e n e s i s a n d o u t c o m e of a u t o i m m u n e h e p a t i t i s in c h i l d r e n . (Abstract# L0698) GS Yanni, ME Ament and RJ Bahar. Los Angeles, CA

DDW Poster of Distinction: L i v e r d i s e a s e in celiac p a t i e n t s . (Abstract# L0468) G Novacek, W Miehsler, F Wrba, P Ferenci a n d H Vogelsang. Vienna, Austria Silent c e l i a c d i s e a s e m a y b e t h e cause o f c h r o n i c u n e x p l a i n e d h y p e r t r a n s a m i n a s e m i a . ( A b s t r a c t # L0659) M Vecchi, E Del Ninno, S Pacchetti, D Conte, M Landoni, MT Bardella and R de Franchis. Milan, Italy N o n a l c o h o l i c f a t t y l i v e r disease: r i s k f a c t o r s a n d l o n g t e r m o u t c o m e s for b e n i g n v e r s u s a g g r e s s i v e disease. (Abstract# L0408) CA Matteoni, ZM Younossi, T Gramlich, Y Liu, L Rybicki and AJ McCullough. Cleveland, OH Treatment of obesity-induced steatohepatitis with v i t a m i n E. (Abstract# L0356) JE Lavine. San Diego, CA AASLD - - H E P A T O C E L L U L A R I N J U R Y AND CARCINOGENESIS

DDW Poster of Distinction: Isoniazid hepatotoxicity in children: an important c a u s e of l i v e r f a i l u r e l e a d i n g to o r t h o t o p i c l i v e r t r a n s p l a n t a t i o n . (Abstract# L0098) CS Chao, M Ament, S McDiarmid, MG Martin, R Bahar, T Denson, NS Pittman, J Rosensweig, AO Scheimann, HL Sharp, FR Sinatra and J Vargas. Los Angeles, CA; New Haven, CT; New York, NY; Philadelphia, PA; Houston, TX and Minneapolis, MN P r e d i c t i o n of h e p a t i c e n c e p h a l o p a t h y i n a c e t a m i n o p h e n overdose. (Abstract# L0564) FV Schicdt, S Bondesen, N Tygstrup and E Christensen. Copenhagen, Denmark

DDW Poster of Distinction: A z o x y m e t h a n e - i n d u c e d f u l m i n a n t h e p a t i c f a i l u r e in mice: c h a r a c t e r i z a t i o n of a n e w a n i m a l model. (Abstract# L0403) KA Matkowskyj, JA Marrero, RE Carroll, R Green and RVBenya. Chicago, IL Hepatic adaptive cytoprotection through the nitric oxide p a t h w a y . (Abstract# L0333) T Kono, M Yoneda, N Ando, K Kamiya, K Ohara, H Karasaki, Y Yamada, Y Yamamoto, H Kotani, K KikuchiUtsumi, J Iwamoto and S Kasai. Asahikawa, Japan The effects of FK409, a n o v e l n i t r i c o x i d e d o n o r , on e x t e n d e d l i v e r r e s e c t i o n w i t h i s c h e m i a i n dogs. (Abstract# L0OlO) M Aiba, I Takeyoshi, S Ohwada, J Kobayashi, Y Kawashima, Y Sunose, T Yamada, H Tsutsumi, K Mastumoto and Y Morishita. Maebashi and Kanagawa, Japan

DDW Poster of Distinction: P450-1B1 e x p r e s s i o n a n d r e g u l a t i o n i n d i f f e r e n t l i v e r cells. (Abstract# L0513) F Piscaglia, T Knittel, D Kobold and G Ramadori. Goettingen, Germany

April 1998

PROGRAMOF THE ANNUALMEETINGP17 AASLD

POSTER

SESSION

--

SUNDAY,

MAY

17, 1998

E v i d e n c e for i n v o l v e m e n t of NADPH r e d u c t a s e i n t h e f o r m a t i o n of s u p e r o x i d e a n i o n r e l e a s e d i n t o h e p a t i c s i n u s o i d . (Abstract# L0482) Y Okamura, H Yokoyama, M Fukuda, T Mizukami, H Ohgo, M Matsumoto, Y Nakamura, D Ito, K Tomita, S Kato and H Ishii. Tokyo, Japan

T r a n s i e n t i s c h e m i c - r e p e r f u s i o n i n j u r y of t h e l i v e r p r o m o t e s t u m o r g r o w t h b y m o d u l a t i o n of a r g i n i n e m e t a b o l i s m a n d s u p p r e s s i o n of i m m u n e function. (Abstract# L0096) A Chan, M D'Angelica, C Hodyl, J You, W Tong, Y Fong and L Blumgart. Hong Kong, China and New York, NY

T e r t i a r y - b u t y l h y d r o p e r o x i d e affects h e p a t o b i l i a r y f u n c t i o n i n h e p a t o c y t e couplets. (Abstract# L0008) J Ahmed-Choudhury and R Coleman. Birmingham, United Kingdom

A q u a n t i t a t i v e m e t h o d to m e a s u r e t e l o m e r a s e a c t i v i t y by hybridization protection assay connected with TRAP for t h e d i a g n o s i s of h e p a t o c e l l u l a r c a r c i n o m a . (Abstract# L0627) H Takaishi, R Nakashio, M Kitamoto, S Takahashi, T Nakanishi, H Tahara, TIde, N Asada, H Aikata, K Kamata, Y Kawakami and G Kajiyama. Hiroshima, Japan

R e d u c t i o n of s p l e n i c f u n c t i o n i m p r o v e s p r o g n o s i s of c i r r h o s i s . (Abstract# L0445) K Murata, K Shiraki, K Sugimoto, K Takase and T Nakano. Tsu, Japan Ursodeoxycliolate alleviates alcohol-induced liver m i t o c h o n d r i a l i n j u r y . (Abstract# L0623) L Tabouy, AJ Zamora, L Oliva, AM Montet, F Beaug~ and JC Montet. Marseille, France S i g n i f i c a n t d e p o s i t i o n of 4-hydroxy-2-nonenal-modifiedp r o t e i n a d d u c t s i n h u m a n a l c o h o l i c l i v e r disease: p o s i t i v e c o r r e l a t i o n w i t h p a r e n c h y m a l iron. (Abstract# L0479) M Ohhira, T Ohtake, A Matsumoto, H Saito, T Kawashima, K Ikuta, K Tanaka, Y Fujimoto, M Ono, S Toyokuni and Y Kohgo. Asahikawa and Kyoto, Japan Hypoxic induction of vascular endothelial growth f a c t o r i n h e p a t i c s t e l l a t e cells d u r i n g l i v e r i n j u r y . (Abstract# L0024) V Ankoma-Sey and Y Wang. Houston, TX Hypoxia-reoxygenation-induced liver injury: interaction between polymorphonuclear leukocytes a n d h e p a t i c s i n u s o i d a l e n d o t h e l i a l cells. (Abstract# L0352) E Lasnier, MC Blanc, M Roch-ArveiUer, C Housset, J Giboudeau and M VaubourdoUe. Paris, France M i d z o n a l s i n u s o i d a l flow b l o c k a f t e r w a r m i s c h e m i a in d i e t a r y i n d u c e d f a t t y l i v e r r a t s . (Abstract# L0216) K Hakamada, M Sasaki, Y Umehara, K Aoki, Y Itabashi, A Murata and T Nishi. Hirosaki, Japan E x vivo l i v e r p e r f u s i o n : a successful t e c h n i q u e of l i v e r

s u p p o r t . (Abstract# L0171) F Filipponi, GM Abouna, U Boggi, L Meacci, S Burchielli, U Barbieri, S Bellentani, LR Fassati, C Tiribelli and G Costa. Pisa, Manama, Modena, Trieste and Milan, Italy A n t i s e n s e o l i g o n u c l e o t i d e - i n d u c e d s u p p r e s s i o n of calpain ~ expression prevents oxidative stress-induced h e p a t o c y t e i n j u r y . (Abstract# L0653) K Umeshita, H Miyoshi, M Sakon, H Ariyoshi, K Taniguchi, S Kishimoto, M Wang, H Nagano, T Kawasaki, M Gotoh, Y Kaneda and M Monden. Osaka, Japan A c t i v a t i o n of c a l p a i n ~ i n t h e d i s e a s e d liver. (Abstract# L0544) M Sakon, S Kishimoto, K Umeshita, H Nagano, M Wang, K Dohno, S Nakamori, H Ariyoshi, T Kawasaki, M Gotoh, S Imajoh-Ohmi and M Monden. Osaka and Tokyo, Japan I n f l u e n c e of t h e W a r d colon t u m o r on t h e h e p a t i c r e s p o n s e t o l i p o p o l y s a c c h a r i d e i n t h e r a t . (Abstract# L0208) VB Grossie, Jr and J Bryant. Houston, TX Chronic hepatitis B carriers have more frequent and m o r e s e v e r e l i v e r i n j u r y w i t h a n t i - t u b e r c u l o s i s drugs. (Abstract# L0689) WM Wong, PC Wu, MF Yuen, WW Yew, CC Cheng, PC Wong, CM Tam, CC Leung and CL Lai. Hong Kong, China

II

T e l o m e r a s e a c t i v i t y of n e e d l e b i o p s i e d l i v e r samples: its usefulness for d i a g n o s i s a n d efficacy j u d g e m e n t of t r e a t m e n t of s m a l l h e p a t o c e l l u l a r c a r c i n o m a . (Abstract# L0331) F Komine, M Moriyama, M Shimojima and Y Arakawa. Tokyo, Japan Macrophage pacification reduces pancreatitis-induced h e p a t o c e l l u l a r i n j u r y t h r o u g h d o w n r e g u l a t i o n of h e p a t i c TNF a n d IL-1. (Abstract# L0696) J Yang, W Denham and J Norman. Tampa, FL M i c r o s a t e l l i t e i n s t a b i l i t y a n d m u t a t i o n s of t r a n s f o r m i n g g r o w t h factor-~ r e c e p t o r t y p e II gene in h e p a t o c e l l u l a r c a r c i n o m a . ( A b s t r a c t # L0498) YM Park, JY Choi, BH Byun and BS Kim. Seoul, Korea P r e l i m i n a r y s t u d y on t h e u s e f u l n e s s of a l b u m i n migrating gamma-glutamyltransferase band in the t r e a t m e n t of h e p a t o c e l l u l a r c a r c i n o m a b y p e r c u t a n e o u s e t h a n o l injection. (Abstract# L0006) G Addolorato, M Pompili, C Zuppi, GP Lorenzelli, L Riccardi, C Rossi, F Pignataro, A Cedrone, GL Rapaccini and G Gasbarrini. Rome and Bologna, Italy KAI1 influences t h e m e t a s t a t i c p o t e n t i a l i n h e p a t o c e l l u l a r c a r c i n o m a s . (Abstract# L0181) H Friess, XZ Guo, FF diMola, JM Heinicke, A AndrenSandberg, HU Graber, HU Baer, A Zimmermann, M Korc and MW Biichler. Bern, Switzerland and Irvine, CA AASLD - - LIVER T R A N S P L A N T A T I O N L i v e r g r a f t loss f r o m r e c u r r e n t a u t o i m m u n e h e p a t i t i s . (Abstract# L0568) L Kim Schluger, E Ferran, M Ye, JV Guarrera, HC Bodenheimer, Jr and PA Sheiner. New York, NY Recurrence of autoimmune hepatitis after liver t r a n s p l a n t a t i o n : l a c k of a s s o c i a t i o n w i t h DR3 m i s m a t c h . (Abstract# L0421) P Milkiewicz, G Skiba, M Hathaway and E Elias. Birmingham, United Kingdom A u t o i m m u n e h e p a t i t i s in t h e l i v e r a l l o g r a f t s of p a t i e n t s t r a n s p l a n t e d for PBC a n d o v e r l a p s y n d r o m e . (Abstract# L0560) R Saxena, L Kim Schluger, F Klion, P Sheiner, S Thung and HC Bodenheimer, Jr. New York, NY O u t c o m e f o l l o w i n g t r a n s p l a n t a t i o n for a u t o i m m u n e h e p a t i t i s . (Abstract# L0655) MT Valdes, MD Zakai, J Cohen, H Tobias, A Talal, D John and L Teperman. New York, NY O r t h o t o p i c D o m i n o l i v e r t r a n s p l a n t a t i o n in f a m i l i a l a m y l o i d o t i c p o l y n e u r o p a t h y . (Abstract# L0572) H Schmidt, M PrSpsting, B Nashan, M Nakazato, U Tietge, K B6ker, J Schlitt, R Pichlmayr and M Manns. Hannover, Germany and Kiyotake, Japan

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A A S L D P O S T E R S E S S I O N - - S U N D A Y , MAY 17, 1998

S p u r cell a n e m i a a n d h e p a t i c i r o n s t o r e s i n p a t i e n t s w i t h alcoholic l i v e r d i s e a s e u n d e r g o i n g o r t h o t o p i c l i v e r t r a n s p l a n t a t i o n . (Abstract# L0499) A Pascoe, P Kerlin, C Steadman, A Clouston, L Powell, E Jazwinska, S Lynch and R Strong. Brisbane, Australia

Living related liver transplants in children confer r e d u c e d n e e d for p u l s e s t e r o i d i m m u n o s u p p r e s s i o n . (Abstract# L0377) JR Lightdale, JF Renz, CL Mudge, PG Stock, JP Roberts, NL Ascher and P Rosenthal. San Francisco, CA

E n d o s c o p i c t h e r a p y of ITBL s t r i c t u r e s in livert r a n s p l a n t e d p a t i e n t s . (Abstract# L0237) RE Hintze, A Adler, W Veltzke, H Abou-Rebyeh, J Langrehr, B Wiedenmann and P Neuhaus. Berlin, Germany

Pediatric liver transplant outcomes are not influenced b y e i t h e r l i v i n g r e l a t e d o r c a d a v e r i c d o n o r sex. (Abstract# L0378) JR Lightdale, JF Renz, CL Mudge, PG Stock, JP Roberts, NL Ascher and P Rosenthal. San Francisco, CA

C o m p a r i s o n of q u a d r u p l e i n d u c t i o n i n c l u d i n g ATG o r IL-2R a n t i b o d y w i t h FK506-based t h e r a p y a f t e r OLT. (Abstract# L0351) JM Langrehr, U Neumann, O Guckelberger, R Lohmann, S Jonas, J Klupp, U Settmacher, M Knoop, WO Bechstein and P Neuhaus. Berlin, Germany H e p a t i c m e t a b o l i s m of SDZ RAD - s t r u c t u r a l i d e n t i f i c a t i o n of t h r e e m e t a b o l i t e s . (Abstract# L0320) GI Kirchner, C Vidal and K-F Sewing. Hann0ver, Germany H e p a t i c m e t a b o l i s m of c o n c o m i t a n t l y a d m i n i s t e r e d c y c l o s p o r i n a n d SDZ RAD [40-O-(2-hydroxyethyl)rapamycin] can be analyzed by automated online e x t r a c t i o n c o m b i n e d w i t h LC/ESI-MS. (Abstract# L0319) GI Kirchner, C Vidal, L Mueller, M Winkler and KF Sewing. Hannover, Germany D o u b l e - b l i n d r a n d o m i z e d t r i a l of S - a d e n o s y l m e t h i o n i n e i n o r t h o t o p i c l i v e r t r a n s p l a n t a t i o n . (Abstract# L0688) T Wong, JM Tredger, J Wendon, D Potter and N Heaton. London, United Kingdom U r s o d e o x y c h o l i c a c i d i n l i v e r t r a n s p l a n t a t i o n : effect on c h o l e s t a s i s a n d r e j e c t i o n . (Abstract# L0547) C Sama, AM Morselli-Labate, GL Grazi, A Mastr0ianni, G Danesi, P Pianta, M Malavolti, A Mazziotti and A Cavallari. Bologna, Italy Cost-effectiveness of d i f f e r e n t s t r a t e g i e s of c y t o m e g a l o v i r u s p r o p h y l a x i s i n r e c i p i e n t s of o r t h o t o p i c l i v e r t r a n s p l a n t a t i o n . (Abstract# L0134) A Das. Cleveland, OH S h o r t t e r m s a f e t y a n d efficacy of f a m c i c l o v i r in p r e v e n t i o n of CMV i n f e c t i o n i n l i v e r t r a n s p l a n t r e c i p i e n t s . (Abstract# L0520) JM Rabkin, SL Orl0ff, CL Corless, KG Benner, KD Flora, HR Rosen and AJ Olyaei. Portland, OR A s s e s s m e n t of p r e o p e r a t i v e p u l m o n a r y f u n c t i o n t e s t i n g w i t h p u l m o n a r y c o m p l i c a t i o n s following l i v e r t r a n s p l a n t a t i o n . (Abstract# L0157) RM Dy, DL Zack, AA Floreani and TM McCashland. Omaha, NE Skin tests predict acute cellular rejection in liver t r a n s p l a n t a t i o n . (Abstract# L0045) AJ Bathgate, JN Plevris, MM Dollinger and PC Hayes. Edinburgh, Scotland Body composition and substrate oxidation in long term s u r v i v o r s a f t e r t r a n s p l a n t a t i o n of l i v e r o r k i d n e y . (Abstract# L0539) A-E Roske, H Hudjetz, T Schfitz, K Budde, L Fritsche, H Lochs and M Plauth. Berlin, Germany U t i l i t y of t r a n s j u g u l a r l i v e r b i o p s y u s i n g l i v e r access b i o p s y a u t o m a t e d needle. (Abstract# L0549) IS Sandhu, J Stephens, J Krysl, JD Durham, DA Kumpe, R Shrestha, TE Trouill0t, GT Everson and BM Bilir. Denver, CO

The p r e d i c t i v e v a l u e of d i f f u s i o n c a p a c i t y i n p a t i e n t s w i t h p r i m a r y b i l i a r y c i r r h o s i s p r i o r to o r t h o t o p i c l i v e r t r a n s p l a n t a t i o n . (Abstract# L0708) DL Zack, RM Dy, AA F10reani and TM McCashland. Omaha, NE I m p r o v e m e n t of r e c i p i e n t s u r v i v a l a n d s u p p r e s s i o n of Kupffer cell a c t i v a t i o n b y i s c h e m i c p r e c o n d i t i o n i n g a f t e r r a t l i v e r t r a n s p l a n t a t i o n . (Abstract# L0027) M Arai and J J Lemasters. Chapel Hill, NC A r o l e for t h e l i v e r n o n p a r e n c h y m a l cell f r a c t i o n i n i m m u n o m o d u l a t i o n . (Abstract# L0380) Z Lin, M de Roos, NL Ascher and J F Renz. San Francisco, CA Nutrition and hormonal supplementation normalizes fixed liver p r o t e i n s y n t h e s i s i m m e d i a t e l y a f t e r l i v e r t r a n s p l a n t a t i o n . (Abstract# L0193) SK Geevarghese, A Bradley, M Sika, JK Wright, DH Van Buren, WC Chapman, TK Blair, K Jabb0ur, CH Hutchins, P Williams, J Phillips and CW Pinson. Nashville, TN M e c h a n i s m s of h e p a t o c e l l u l a r p r o l i f e r a t i o n d u r i n g e a r l y life a n d s e n e s c e n c e in t h e F344 r a t . (Abstract# L0524) P Rajvanshi, S Sigal, R S0khi, LM Reid and S Gupta. Bronx and New York, NY; Chapel Hill, NC D i s r u p t i o n of s i n u s o i d a l e n d o t h e l i a l b a r r i e r s d u r i n g liver repopulation with transplanted hepatocytes. (Abstract# L0523) P Rajvanshi, RP Sokhi, S Slehria, A Kerr, PM N0vik0ff and S Gupta. Bronx, NY Percutaneous intrahepatic hepatocyte transplantation w i t h f l u o r o s c o p i c guidance. (Abstract# L0151) V Dixit, P D0ng, M Arthur, J Roberts, P Martin and G Gitnick. Los Angeles, CA D e v e l o p m e n t of a novel m a t r i x f o r m e s e n t e r i c h e p a t o c y t e t r a n s p l a n t a t i o n . (Abstract# L0428) M Miyazawa, M Ueda, M Kitajima and L Griffith. Tokyo, Japan and Boston, MA A novel a p p r o a c h to m o n i t o r t r a n s p l a n t e d h e p a t o c y t e s i n spleen: Tc 99M GSA in vlvo scan. (Abstract# L0379) TC Lin, G Gut, W C01e, D Guenette, J Lear, N Leitman, J Sible and BM Bilir. Ankara, Turkey AASLD - - H E P A T O C E L L U L A R C A R C I N O M A A N D BILIARY C A N C E R

D D W Poster of Distinction: A s s o c i a t i o n of loss of h e t e r o z y g o s i t y on c h r o m o s o m e 13q w i t h h e p a t o c e l l u l a r c a r c i n o m a p r o g r e s s i o n . (Abstract# L0451) S Nakamori, Y Fujiwara, H Nagano, M Sak0n, M Monden, S Sasaki, H Furukawa, S Imaoka, T Kuroki and Y Nakamura. Osaka and Tokyo, Japan

II I]

April 1998 II

PROGRAMOF THE ANNUALMEETINGP19 AASLD

POSTER

SESSION

DDW Poster of Distinction: P r o g n o s i s of h e p a t o c e l l u l a r c a r c i n o m a in r e l a t i o n to t r e a t m e n t m e t h o d s u s i n g a n e w s t a g i n g scheme. ( A b s t r a c t # L0650) SH Urn, HS Ryu, MR Park, JW Lee, HJ Park, HJ Chun, CD Kim, JH Hyun, YH Kim and SO Seo. Seoul, Korea A n e w s t a g i n g s y s t e m of h e p a t o c e l l u l a r c a r c i n o m a b a s e d on p r o g n o s t i c i n d e x in c o n s i d e r a t i o n of p r o g n o s t i c f a c t o r s on n a t u r a l h i s t o r y . (Abstract# L0649) SH Um, HS Ryu, MR Park, JW Lee, SJ Lee, KH Kim, HJ Park, YT Jeen, HJ Chun, CW Song, SW Lee, CD Kim, JH Hyun, SO Seo and YH Kim. Seoul, Korea P r o g n o s t i c r i s k f a c t o r s i n h e p a t i c r e s e c t i o n for h e p a t o c e l l u l a r c a r c i n o m a : t h e effect of p r o p h y l a c t i c a r t e r i a l i n f u s i o n c h e m o t h e r a p y . (Abstract# L0296) K Kawano, T Kai, K Nakashima, M Aramaki, Y Morii, H Yokoyama, T Yoshida and S Kitano. Hasama-machi 87955 P r e - l i v e r t r a n s p l a n t c h e m o t h e r a p y does n o t i m p r o v e s u r v i v a l i n HCC p r i o r OLT. (Abstract# L0034) S Badalamenti, MJ Rodriguez, J Smith, AG Tzakis and ER Schiff. Miami, FL P r o g n o s t i c score, a l k a l i n e p h o s p h a t a s e r a t i o a n d i n d o c y a n i n e g r e e n e l i m i n a t i o n c o n s t a n t s as p r e d i c t o r s of h e p a t i c f a i l u r e a f t e r h e p a t e c t o m y . (Abstract# L0297) Y Kawashima, T Imai, S Ohwada, I Takeyoshi, T Ogawa, T Ohya, K Kawashima, T Yamada, S Kawate, M Nakasone, M Aiba and Y Morishita. Maebashi, Japan

DDW Poster of Distinction: S t e n t p l a c e m e n t i n t o t h e p o r t a l v e i n for h e p a t o c e l l u l a r c a r c i n o m a s i n v a d i n g t h e m a i n p o r t a l vein. (Abstract# L0270) T Ito, K Shiraki, K Sugimoto, H Wagayama, K Murata, A Shimizu, K Takase, T Nakano and K Yamakado. Tsu, Japan

DDW Poster of Distinction: Des-~-carboxy p r o t h r o m b i n is t h e m o s t i m p o r t a n t p r e d i s p o s i n g f a c t o r of p o r t a l v e i n t u m o r t h r o m b u s i n h e p a t o c e l l u l a r c a r c i n o m a . (Abstract# L0328) Y Koike, S Shiina, M Imamura, S Obi, K Hamamura, S Sato, H Yoshida, Y Dan, T Goto, T Okudaira, N Kato, T Kawabe, H Yoshida, Y Shiratori and M Omata. Tokyo, Japan

DDW Poster of Distinction:

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SUNDAY,

MAY

1 7, 1998

P e r c u t a n e o u s e t h a n o l i n j e c t i o n t h e r a p y for p a t i e n t s with hepatocellular carcinoma whose serum total b i l i r u b i n levels w e r e 2.0 mg/dl o r m o r e . (Abstract# L0587) S Shiina, M Imamura, T Teratani, S Obi, K Hamamura, S Sato, H Yoshida, Y Koike, Y Dan, N Kato, Y Niwa, T Okudaira, H Yoshida, T Kawabe, Y Shiratori and M Omata. Tokyo, Japan A n a p p r a i s a l of t r a n s a r t e r i a l i m m u n o e m b o l i z a t i o n for hepatocellular carcinoma - a clinicopathological study. (Abstract# L0652) K Umeshita, M Sakon, T Yoshida, T Kanai, H Nagano, K Dono, S Nakamori, M Gotoh, K Wakasa and M Monden. Osaka, Japan P e r c u t a n e o u s m i c r o w a v e c o a g u l a t i o n t h e r a p y for s m a l l hepatocellular carcinomas that were confirmed by computed tomography during arterial portography. (Abstract# L0247) Y Hoshino, N Izumi, M Shimizu, H Watanabe, O Noguchi, M Uchihara, S Miyake, T Sakai and C Sato. Tokyo, Japan P e r c u t a n e o u s i n f a r c t i o n t h e r a p y for h e p a t o c e l l u l a r c a r c i n o m a . (Abstract# L0262) M Imamura, S Shiina, T Teratani, S Obi, S Sato, K Hamamura, Y Koike, Y Dan, H Yoshida, T Okudaira, F Kanai, N Kato, H Yoshida, T Kawabe, Y Shiratori and M Omata. Tokyo, Japan Kupffer cell f u n c t i o n is i m p o r t a n t t o o v e r c o m e s e p t i c c o m p l i c a t i o n s a f t e r p a r t i a l l i v e r r e s e c t i o n . (Abstract# L0417) C Meijer, HA Prins, A Huijsman, EP van Rees, N van Rooijen, S Meijer and PAM van Leeuwen. Amsterdam, The Netherlands Food intake and substrate utilization in patients with

h e p a t o c e l l u l a r c a r c i n o m a . (Abstract# L0574) T Schiiltz, A-E Roske, A-C Lehmann, H Lochs and M Plauth. Berlin, Germany E x p r e s s i o n of F a s a n d F a s l i g a n d i n d o x o r u b i c i n i n d u c e d c a r d i a c i n j u r y i n r a t . (Abstract# L0593) K Shiraki and H Takahashi. Boston, MA Decreased leukocyte phagocytosis in patients with l i v e r m e t a s t a s e s . (Abstract# L0685) MJ Wiezer, C Meijer, ATJ Tool, APJ Houdijk, RHJ Beelen, D Roos, S Meijer and PAM van Leeuwen. Amsterdam, The Netherlands

A new ultrasound imaging method in the abdominal a r e a : h a r m o n i c i m a g i n g w i t h o u t a n e n h a n c i n g agent. (Abstract# L0226) S Hayakawa, H Goto, Y Hirooka, A Itoh, Y Watanabe, Y Ishiguro, S Kojima, S Hashimoto, Y Hayakawa, Y Naitoh, PN Burns and JE Powers. Nagoya, Japan; Toronto, Canada and Bothell, WA

E x p r e s s i o n a n d p r o c e s s i n g of g a s t r i n in p a t i e n t s w i t h hepatocellular carcinoma, fibrolamellar carcinoma and c h o l a n g i o c a r c i n o m a . (Abstract# L0083) ME Caplin, K Savage, K Khan, J Rode, B Brett, A Varro, D Michaeli, RE Pounder and AP Dhillon. London and Liverpool, United Kingdom; Darwin, Australia and Woodland, CA

C o r r e l a t i o n b e t w e e n CT a n d l a p a r o s c o p y f i n d i n g s in p a t i e n t s w i t h h e p a t o c e l l u l a r c a r c i n o m a . (Abstract# L0418) P Mendez, S Badalamenti, L Jeffers, E Molina, KR Reddy and ER Schiff. Miami, FL

Magnetic resonance cholangiopancreatography in the d i a g n o s i s of e x t r a h e p a t i c bile d u c t c a n c e r : c o m p a r i s o n with endoscopic retrograde cholangiopancreatography. (Abstract# L0U6) JB Chung, JH Seo, MJ Kim, JK Kang and IS Park. Seoul, Korea

D e t e r m i n a t i o n of a safe cyclic v a s c u l a r c l a m p i n g m e t h o d for l i v e r s u r g e r y b y m e a s u r i n g a c t i v a t i o n of c a l p a i n ~. (Abstract# L0546) M Sakon, M Wang, K Umeshita, H Miyoshi, K Taniguchi, S Kishimoto, H Nagano, K Dohno, S Nakamori, H Ariyoshi, T Kawasaki, M Gotoh, S Imajoh-Ohmi and M Monden. Osaka and Tokyo, Japan

Cholangiocarcinoma in patients with hepatolithiasis a n d cystic d i l a t a t i o n of bile ducts. (Abstract# L0088) F Cetta, G Nuzzo and Y Nimura. Siena and Rome, Italy; Nagoya, Japan

P20 PROGRAM OF THE ANNUAL MEETING

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GASTROENTEROLOGY Vol. 114~ No. 4

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ssio

D D W Poster of Distinction: M u t a t i o n s of c-Ki-ras i n g a l l b l a d d e r c a r c i n o m a s associated w i t h gallstones a n d i n those associated w i t h cystic bile d u c t d i l a t a t i o n . (Abstract# L0091) F Cetta, G Montalte, M Petracci, M Zuckermann, C Baldi, P Piro, L Civeli, A Cariati, H Tom0no and Y Nimura. Siena and Genoa, Italy; Nagoya, Japan The i m p a c t of c o n c o m i t a n t h e p a t o l i t h i a s i s o n long t e r m s u r v i v a l of p a t i e n t s w i t h p e r i p h e r a l c h o l a n g i o c a r c i n o m a . (Abstract# L0105) MF Chen, YY Jan, LB Jeng, TL Hwang, CS Wang, SC Chen, TC Chao, HM Chen, WC Lee and TS Yeh. Taipei, Taiwan Long t e r m s u r v i v a l after r e s e c t i o n of p r o x i m a l bile d u c t c a r c i n o m a (Klatskin tumors). (Abstract# L0195) MF Gerhards, TM van Gulik, A Bosma, H ten HoopenNeumann, PCM Verbeek, DG Gonzalez, LT de Wit and DJ Gouma. Amsterdam, The Netherlands Color D o p p l e r signals after t r a n s c a t h e t e r a r t e r i a l e m h o l i z a t i o n to e v a l u a t e r e s p o n s e to t r e a t m e n t for h e p a t o c e l l u l a r c a r c i n o m a . (Abstract# L0554) S Sato, S Shiina, M Imamura, T Teratani, S Obi, K Hamamura, H Y0shida, Y K0ike, Y Dan, T Okudaira, N Kate, T Kawabe, H Yoshida, Y Shirateri and M Omata. Tokyo, Japan Complete a b l a t i o n of color Doppler signals to e v a l u a t e r e s p o n s e to t r e a t m e n t w i t h p e r c u t a n e o u s e t h a n o l i n j e c t i o n for h e p a t o c e l l u l a r c a r c i n o m a . (Abstract# L0555) S Sato, S Shiina, M Imamura, T Teratani, S Obi, K Hamamura, H Yoshida, Y Koike, Y Dan, T Kawabe, T Okudaira, N Kate, H Yoshida, Y Shirateri and M Omata. Tokyo, Japan P e r c u t a n e o u s r a d i o - f r e q u e n c y tissue a b l a t i o n - first a p p l i c a t i o n s o n in vitro b o v i n e livers. (Abstract# L0220) J H~nsler, D Becket, W Mfiller, D Neureiter and EG Hahn. Erlangen-Nuremberg and Tuttlingen, Germany T o w h a t e x t e n t s h o u l d one t r y to lower t u m o r m a r k e r s

i n t r e a t i n g h e p a t o c e l l u l a r c a r c i n o m a ? (Abstract# L0218) K Hamamura, S Shiina, M Imamura, T Teratani, S Obi, S Sato, H Y0shida, Y Koike, T Dan, T Okudaira, N Kate, H Yoshida, T Kawabe, Y Shirat0ri and M Omata. Tokyo, Japan AGA Poster Session

8:00-5:00 p m

Hall D Ernest N. Morial Convention Center

Authors are required to present during the Poster Session from 12:00-2:30 pm

Those posters identified as DDW Posters of Distinction have received review scores that place them within the top 10% of all posters. We encourage you to make them a priority as you visit the poster session. ESOPHAGEAL, GASTRIC, AND DUODENAL DISORDERS - - C E L L BIOLOGY OF SECRETION Nonspecific effects of t h e p h a r m a c o l o g i c a l probes c o m m o n l y u s e d for t h e a n a l y s i s of signal t r a n s d u c t i o n i n r a b b i t p a r i e t a l cells. (Abstract# G1292) T Urushidani, Y Sugita and T Naga0. Tokyo, Japan P r o l i f e r a t i o n of r o u g h e n d o p l a s m i c r e t i c u l u m i n gastric ECL cells reflects t h e m a g n i t u d e , n o t d u r a t i o n , of h y p e r g a s t r i n e m i a . (Abstract# G l U 4 ) W Rubin, R Mackay, D Jennings, B Huang and P Rose. Philadelphia, PA and Deerfield, IL

II

- s A m m o n i u m chloride r e v e r s i b l y blocks acid s e c r e t i o n b y m e c h a n i s m s n o t r e l a t e d to the i n h i b i t i o n of b a r i u m sensitive K÷-channels. (Abstract# G0583) SJ Hagen, M Prasad and R Jansons. Boston, MA Cytological t r a n s f o r m a t i o n s associated w i t h p a r i e t a l cell s t i m u l a t i o n : critical steps i n the a c t i v a t i o n cascade. (Abstract# G0212) BJ Agnew, J Duman and JG Forter Berkeley, CA M e a s u r e m e n t of H÷/K÷-ATPase a n d Na÷/K÷-ATPase activities from h u m a n gastric biopsies. (Abstract# G1319) B V~s~rhelyi, L Pr6nai, I K0csis, T Z~goni, T 6nodi, T Tulassay and Z Tulassay. Budapest, Hungary A n e w concept r e g a r d i n g gastric acid s e c r e t i o n m e c h a n i s m . I n v o l v e m e n t of gastric p a r i e t a l cells m e m b r a n e c a r b o n i c a n h y d r a s e IV i n HCI secretion. (Abstract# G1080) I Pu~ca.~. Simleu Silvaniei, Romania ESOPHAGEAL, GASTRIC, AND D U O D E N A L DISORDERS - - R E G U L A T I O N OF M U C U S AND BICARBONATE SECRETION F u n c t i o n a l h e t e r o g e n e i t y i n m u c o u s n e c k cells a n d surface m u c o u s cells of the r a b b i t s t o m a c h r e v e a l e d b y video microscopy. (Abstract# G0905) I Matsushita, K Hanajima, H Hanai, E Kaneko, T Sakurai and S Terakawa. Hamamatsu, Japan Dual role of CFTR i n cAMP-stimulated HCO 3 s e c r e t i o n across m u r i n e d u o d e n u m . (Abstract# G0381) LL Clarke and MC Harline. Columbia, MO S t i m u l a t o r y a c t i o n of n i t r i c oxide o n b i c a r b o n a t e secretion i n the i s o l a t e d bullfrog d u o d e n u m . (Abstract# G0517) O Furukawa, S Sugamote, M Kitamura and K Takeuchi, Kyote, Japan

Effect of ecabet sodium, a novel a n t i u l c e r drug, o n epithelial r e s t i t u t i o n following i n j u r y b y h y p e r o s m o l a r s o d i u m chloride i n bullfrog s t o m a c h i n v / t r ~ (Abstract# G0516) 0 Furukawa, M Kitamura, K Suzuki and K Takeuchi. Kyot0, Japan Surface pH of r a t s t o m a c h is r e g u l a t e d b y l u m i n a l pH a n d h o r m o n a l agonists. (Abstract# G0378) S Chu, S Tanaka, JD Kaunitz and MH Montrose. Los Angeles, CA and Baltimore, MD C o r r e l a t i o n of surface pH versus m u c u s gel t h i c k n e s s b y i n vivo confocal microscopy of r a t gastric mucosa. (Abstract# G0377) S Chu, S Tanaka, JD Kaunitz and MH M0ntrose. Los Angeles, CA and Baltimore, MD

D D W Poster of Distinction: A novel in vitro model to e x a m i n e m e c h a n i s m s of B r u n n e r ' s g l a n d s e c r e t i o n i n the g u i n e a pig d u o d e n u m . (Abstract# G0951) BA Moore and S Vanner. Kingston, Canada A u g m e n t e d s a l i v a r y protective p o t e n t i a l : is it one e x p l a n a t i o n of t h e lower p r e v a l e n c e of reflux esophagitis a n d c o m p l i c a t i o n s i n African-Americans? (Abstract# G0331) RL Brown, T Zbr0ch, M Marcinkiewicz, RW McCallum and J Sarosiek. Kansas City, KS

P R O G R A M O F T H E A N N U A L M E E T I N G P21

A p r i l 1998

II

A G A P O S T E R S E S S I O N m S U N D A Y , M A Y 17, 1998

The CFTR a n i o n c h a n n e l is t h e p r e d o m i n a n t t r a n s p o r t p a t h w a y for HCO 3" i n a g o n i s t - s t i m u l a t e d secretion i n r a t d u o d e n u m . (Abstract# Gl154) U Seidler, M Guba, M Walter and M Gregor. Ttibingen and Regensburg, Germany

A d r e n o m e d u l l i n i n h i b i t s gastric a c i d s e c r e t i o n a n d m o t i l i t y i n the rat. (Abstract# G0512) K Fukuda, H Tsukada, M Onomura, T Saito, M Kodama, H Nakamura, T Taniguchi, M Hosokawa and Y Seino. Kyoto, Japan

ESOPHAGEAL, GASTRIC, AND DUODENAL DISORDERS - - R E G U L A T I O N OF GASTRIC ACID SECRETION

Soya b e a n lectin a n d b r o a d b e a n l e c t i n s t i m u l a t e g a s t r i n release from r a b b i t G cells i n p r i m a r y culture. (Abstract# G0308) PW Bliss, M Jordinson, ZV Healey, N Arebi and J Calam. London, United Kingdom

DDW Poster of Distinction: Is l e p t i n a g a s t r i c h o r m o n e ? (Abstract# G0829) S Levasseur, S Attoub, J-P Laigneau, M-N B0rtoluzzi, L Moizo, S Kermorgant, T Lehy, Y Lemarchand-Brustol, A Bado and MJM Lewin. Paris, France

B r o a d b e a n a n d c o n c a n a v a l i n A l e c t i n s i n h i b i t 14Ca m i n o p y r i n e a c c u m u l a t i o n by r a b b i t p a r i e t a l cells i n p r i m a r y culture. (Abstract# G0602) ZV Healey, M Jordinson, PW Bliss, N Arebi and J Calam. London, United Kingdom

DDW Poster of Distinction: E n d o t h e l i n , r e l e a s e d from t h e f u n d u s of the stomach, p a r t i c i p a t e s i n t h e r e g u l a t i o n of acid secretion. (Abstract# G0744) S Koduru, A Hirsch, R McCuen and ML Schubert. Richmond, VA Role of n i t r i c oxide i n l i p o p o l y s a c c h a r i d e - i n d u c e d i n h i b i t i o n of g a s t r i c g a s t r i n secretion. (Abstract# GO7O2) M Kawano, K Sumii, K Kodama, K Nojima, R Yamauchi, S Okahara, M Sumii, S Tanaka, M Yoshihara, K Haruma, G Kajiyama and A Tari. Hiroshima, Japan I n t e r a c t i o n b e t w e e n g a s t r i n a n d n o n - g a s t r i n acid s t i m u l a t i n g p e p t i d e i n h u m a n islet cell t u m o r s on g a s t r i c acid s e c r e t i o n i n rats. (Abstract# Gl197) Y Song, T-M Chang and WY Chey. Rochester, NY I s o l a t i o n a n d i d e n t i f i c a t i o n of the powerful s t i m u l a n t s of gastric acid o u t p u t i n alcoholic beverages p r o d u c e d b y f e r m e n t a t i o n . (Abstract# G1266) S Teyssen, M Schimiczek, G Gonz~lez-Calero, D Hartmann, A Korn and MV Singer. Mannheim, Germany P o t e n t i a l role of n i t r i c oxide i n d i s t e n t i o n - i n d u c e d gastric acid h y p e r s e c r e t i o n i n rats. (Abstract# G0729) M Kitamura, M Kubomi, S Kato and K Takeuchi. Kyoto, Japan I n t e r a c t i v e roles of e n d o g e n o u s p r o s t a g l a n d i n s a n d n i t r i c oxide i n g a s t r i c acid s e c r e t o r y r e s p o n s e following damage. (Abstract# G0777) M Kubomi, S Kato, 0 Furukawa and K Takeuchi. Kyoto, Japan Effects of i n t e r l e u k i n - 8 o n h i s t a m i n e release from r a t E C L cells. (Abstract# G0936) Y Minagawa, H Tomono, K Yakabi and T Nakamura. Chiba, Japan Physiological doses of s e c r e t i n i n h i b i t only very low levels of s t i m u l a t e d gastric acid secretion i n u r e t h a n e a n e s t h e t i z e d rats. (Abstract# G0556) P Gong, JH Walsh, Y Zong and TE Solomon. Los Angeles, CA C o m p a r i s o n of secretin-NH2, secretin-Gly a n d secretinOH o n p a n c r e a t i c a n d gastric s e c r e t i o n indicates t h e existence of a s e c r e t i n r e c e p t o r subtype. (Abstract# G4693) P Gong, JR Reeve, Jr, JH Walsh, Y Zong, FJ Ho and TE Solomon. Los Angeles, CA A role for s a l i v a r y n i t r i t e i n t h e c o n t r o l of g a s t r i n release i n h u m a n s . (Abstract# G0617) M Holm, C yon Bothmer, A Pettersson and L F~ndriks. G6teborg, Sweden

ESOPHAGEAL, GASTRIC, AND DUODENAL DISORDERS - - A N T I S E C R E T O R Y DRUGS: PHARMACODYNAMICS AND P H A R M A C O K I N E T I C S CYP2C19 genotype s t a t u s a n d effect of omeprazole o n i n t r a g a s t r i c pH. (Abstract# G0521) T Furuta, K Ohashi, M Takashima, H Hanai, T Kubota, T Ishizaki and E Kaneko. Hamamatsu and Tokyo, Japan Omeprazole lowers gastric j u i c e a s e o r b i c acid a n d elevates gastric j u i c e n i t r i t e c o n c e n t r a t i o n s . (Abstract# G0966) C Mowat, A Carswell and KEL McColl. Glasgow, Scotland R e b o u n d acid h y p e r s e c r e t i o n post-omeprazole correlates with o n - t r e a t m e n t i n t r a g a s t r i c pH a n d ont r e a t m e n t p l a s m a gastrin. (Abstract# G0542) D Gillen, A Wirz, JES Ardill and KEL McColl. Glasgow, Scotland N e u t r a l i z a t i o n b y a m m o n i a c a n n o t e x p l a i n H. pylorfs p o t e n t i a t i o n of omeprazole's efficacy. (Abstract# G0541) D Gillen, A Wirz, W Neithercut, J Ardill and KEL McCoU. Glasgow, Scotland I n t r a v e n o u s p a n t o p r a z o l e r a p i d l y a n d effectively controls acid o u t p u t i n p a t i e n t s w i t h ZollingeroEllison s y n d r o m e . (Abstract# G0926) DC Metz, E Lew, CE Forsmark, W Bochenek, M Beg and J Pisegna. Philadelphia and Radnor, PA; Gainesville, FL and Los Angeles, CA N o c t u r n a l gastric acid b r e a k t h r o u g h w i t h omeprazole 4 0 m . g . d a i l y - does d o s i n g s c h e d u l e m a k e a difference? (Abstract# G0591) JG Hatlebakk, P Katz, B Kuo and DO Castell. Philadelphia, PA G e r a n y l g e r a n y l a c e t o n e , a novel a n t i u l c e r drug, s t i m u l a t e s h e x o s a m i n e p r o d u c t i o n i n a r a t gastric m u c o s a l cell line t h r o u g h b i n d i n g to a specific cytosolic p r o t e i n . (Abstract# G0590) MS Hassan, Y Kinoshita, A Okada, T Maekawa, H Fukui and T Chiba, Kobe and Kyoto, Japan Abolition of p e n t a g a s t r i n s t i m u l a t e d a l k a l i n e tide u s i n g t h e c a r b o n i c a n h y d r a s e i n h i b i t o r , acetazolamide. (Abstract# G0449) R Drori, A Regev, GM Fraser and Y Niv. Tel Aviv, Israel P h a r m a c o d y n a m i c s a n d p h a r m a c o k i n e t i c s of c o n t i n u o u s omeprazole i n f u s i o n followed by once or twice daily oral a d m i n i s t r a t i o n . (Abstract# G1268) ABR Thomson, G Hasselgren, M Keelan, J Lee, A Matisko, P Sinclair and K ROhss. Edmonton, Canada and Astra Hiissle, Sweden

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L a n s o p r a z o l e effectively s u p p r e s s e s i n t r a g a s t r i c a c i d i t y w h e n a d m i n i s t e r e d via g a s t r o s t o m y as i n t a c t g r a n u l e s i n o r a n g e juice. (Abstract# GU64) VK Sharma, EA Ugheoke, R Vasudeva and CW H0wden. Columbia, SC

Acute a n d c h r o n i c s t r e s s - i n d u c e d oxidative gastrointestinal mucosal injury in rats and protection b y b i s m u t h subsalicylate. (Abstract# G0250) D Bagchi, CB Williams, M Milnes, RL Krohn, M Bagchi, J Balmoori, X Ye, MX Tran, SJ Stohs, OR Carryl and S Mitra. Omaha, NE and Mason, OH

The r e v e r s i b l e H÷,K+-ATPase-antagonist BY841 is more effective i n e l e v a t i n g gastric p H i n HeHcobaeterpylorl positive t h a n i n H p - n e g a t i v e v o l u n t e e r s . (Abstract# Gl101) T Medal, M Hartmann, R L~hmann, W Wurst and W Schepp. Munich and Constance, Germany

Cholecystokinin-inducedgastroprotection against gastric i n j u r y from acidified e t h a n o l is a physiologic effect. (Abstract# G0350) AA Castaneda, DW Mercer, TE Collins, L Chang and G Greeley. Houston and Galveston, TX

Twice d a i l y d o s i n g of o m e p r a z o l e a n d l a n s o p r a z o l e m o r e effective t h a n once d a i l y dosing? (Abstract# G0539) WP Geus, PGH Mulder, KH Gan and CBHW Lamers. The Hague, Rotterdam and Leiden, The Netherlands Effect of low dose l a n s o p r a z o l e a n d omeprazole on gastric a c i d i t y i n Helieobacterpylori n e g a t i v e v o l u n t e e r s . (Abstract# G0929) M Meyer, R Meier and H Messmer. Basel and MitlSdi, Switzerland I n h i b i t i o n of gastric a c i d i t y i n c h i l d r e n b y lansoprazole i n granules. (Abstract# G1004) G Oderda, E Chiorboli, A Rapa, O Haitink and G Bona. Novara, Italy pH3 h o l d i n g time c o r r e l a t e s w i t h s e r u m p e p s i n o g e n I/II r a t i o i n p a t i e n t s w i t h Helicobaeterpylor~positive a t r o p h i c gastritis. (Abstract# Gl174) T Shimatani, M In0ue, Y H0rikawa, Y Kawai, C Ta0 and G Kajiyama. Hiroshima, Japan ESOPHAGEAL, GASTRIC, AND DUODENAL DISORDERS - - M E C H A N I S M S OF MUCOSAL PROTECTION Effects of p r o s t a g l a n d i n E1 o n r o l l i n g of leukocytes a n d endothelial damage in the stomach induced by thermal i n j u r y i n rats. (Abstract# G1398) M Yoshida, G Wakabayashi, H Ishikawa, Y Otani, M Shimazu, S Miura, H Ishii and M Kitajima. Tokyo, Japan Role of e n d o g e n o u s p r o s t a g l a n d i n E2 as a m o d u l a t o r of release of c a l c i t o n i n g e n e - r e l a t e d p e p t i d e to p r e v e n t e t h a n o l - i n d u c e d gastric m u c o s a l i n j u r y i n rat. (Abstract# G0313) K Boku, M Majima, T Ohno, T Saeki, H Hayashi, K Nishiyama, M Katori and K Saigenji. Kanagawa, Japan C a p s a i c i n p r e v e n t s e t h a n o l - i n d u c e d gastric lesion b y s u p p r e s s i o n of c o n s t r i c t i o n of collecting v e n u l e s i n r a t s a s t u d y of i n t r a v i t a l microscopy. (Abstract# Gl120) T Saeki, T Ohno, K Boku, H Hayashi, K Saigenji, M Majima and M Katori. Sagamihara and Isehara, Japan

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R e d u c t i o n i n c i r c u l a t o r y p l a t e l e t n u m b e r b y antip l a t e l e t a n t i b o d y a n d i n h i b i t i o n of p l a t e l e t aggregation p r e v e n t e t h a n o l - i n d u c e d m u c o s a l i n j u r y i n rats. (Abstract# G1011) T Ohno, M Majima, M Hamura, T Saeki, K Boku, I Hayashi, M Katori and K Saigenji. Isehara and Sagamihara, Japan M e c h a n i s m of g a s t r o p r o t e c t i o n b y b i s m u t h s u b s a l i c y l a t e a g a i n s t c h e m i c a l l y i n d u c e d oxidative i n j u r y i n h u m a n gastric m u c o s a l cells. (Abstract# G0251) D Bagchi, TR McGinn, X Ye, J Balmoori, M Bagchi, SJ Stohs, C Kuszynski, OR Carryl and S Mitra. Omaha, NE and Mason, OH

A s p i r i n negates l i p o p o l y s a c c h a r i d e - i n d u c e d g a s t r o p r o t e c t i o n from ethanol. (Abstract# G0349) AA Castaneda, DW Mercer, TH Liu, WO Blankenship, GS Smith and TA Miller. Houston, TX and St Louis, MO P o l a p r e z i n c protects gastric m u c o s a l cells from n o x i o u s agents t h r o u g h a n t i o x i d a n t p r o p e r t i e s in vitro. (Abstract# G06U) H Hiraishi, T Oinuma, T Sasai, N Yamaguchi, T Shimada and A Terano. Tochigi, Japan A sialyl Lewis X a n a l o g u e a t t e n u a t e s gastric erosions i n d u c e d by t h e r m a l i n j u r y i n rats. (Abstract# G0648) H Ishikawa, M Y0shida, G Wakahayashi, Y Otani, M Shimazu, T Kubota, K Kumai and M Kitajima. Tokyo, Japan

D D W Poster of Distinction: P r o s t a g l a n d i n E r e c e p t o r s u b t y p e s i n v o l v e d i n gastric cytoprotection a g a i n s t e t h a n o l i n rats. (Abstract# G1247) K Takeuchi, K Yagi, K Tashima, O Furukawa and H Ukawa. Kyoto, Japan

D D W Poster of Distinction: G a s t r o d u o d e n a l b i c a r b o n a t e s e c r e t i o n i n mice with p r o s t a g l a n d i n E r e c e p t o r gene d i s r u p t i o n . (Abstract# G1246) K Takeuchi, H Ukawa, 0 Furukawa, S Kato, F Ushikubi and S Narumiya. Kyoto, Japan D y n a m i c i n t e g r a t e d r e s p o n s e of d u o d e n a l m u c o s a l defense m e c h a n i s m s to acid in vivw. m e a s u r e m e n t i n a novel system. (Abstract# G0215) Y Akiba and JD Kaunitz. Los Angeles, CA Cellular m e c h a n i s m of a d a p t i v e c y t o p r o t e c t i o n to l u m i n a l acid i n r a t d u o d e n a l mucosa. (Abstract# G0214) Y Akiba, PH Guth and JD Kaunitz. Los Angeles, CA E n h a n c e d s a l i v a r y b i c a r b o n a t e , t r a n s f o r m i n g growth factor-a, p r o t e i n a n d p r o s t a g l a n d i n E 2 as p o t e n t i a l factors p r e v e n t i n g t h e d e v e l o p m e n t of reflux esophagitis i n p a t i e n t s with g a s t r o e s o p h a g e a l reflux disease. (Abstract# Gl136) J Sar0siek, T Zbroch, WA Gramley, M Marcinkiewicz, KHan, C Poplawski and RW McCallum. Kansas City, KS and Charlottesville, VA D i s t i n c t secretory profiles w i t h i n t h e esophageal preepithelial b a r r i e r i n African-Americans a n d Caucasians: its p o t e n t i a l p a t h o g e n e t i c i m p l i c a t i o n s . (Abstract# G1405) T Zbr0ch, M Marcinkiewicz, RL Brown, C Poplawski, RW McCallum and J Sarosiek. Kansas City, KS New evidence for the p r o t e c t i v e role the m u c u s l a y e r w i t h i n the esophageal pre-epithelial i n p a t i e n t s w i t h gastroesophageal reflux disease. (Abstract# G1406) T Zbroch, WA Gramley, M Marcinkiewicz, K Han, C Poplawski, RW McCallum and J Sarosiek. Kansas City, KS and Charlottesville, VA

April1998

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A G A P O S T E R S E S S I O N - - S U N D A Y , MAY 17, 1998 Role of t h e a c t i n c y t o s k e l e t o n i n p r o t e c t i o n b y growth factors a g a i n s t a s p i r i n - i n d u c e d d a m a g e i n a h u m a n gastric cell line. (Abstract# G0260) A Banan, GS Smith, Y Deshpande, ER Kokoska and TA Miller. St Louis, MO

I n d u c t i o n of m u c o s a l d a m a g e of s t o m a c h b y i n n o c u l a t i o n of p l a s m i d DNA e n c o d i n g interferon-y. (Abstract# G0646) A Irisawa, A Saito, Y Sato, K Obara, T Nishimaki and R Kasukawa. Fukushima, Japan

Role of p r o t e i n k i n a s e C a n d c a l c i u m effiux i n p r o t e c t i o n b y g r o w t h factors a g a i n s t a s p i r i n - i n d u c e d i n j u r y i n a h u m a n gastric cell line. (Abstract# G0259) A Banan, GS Smith, Y Desphande, ER Kok0ska and TA Miller. St Louis, MO

F u r t h e r evidence for the q u a n t i t a t i v e a n d q u a l i t a t i v e i m p a i r m e n t i n t h e esophageal p r e - e p i t h e l i a l b a r r i e r i n p a t i e n t s w i t h reflux esophagitis. (Abstract# G0881) M Marcinkiewicz, T Zbroch, C Poplawski and J Sarosiek. Kansas City, KS

PYY at physiologic doses i n c r e a s e s gastric p r o t e c t i o n a g a i n s t i n t r a g a s t r i c e t h a n o l t h r o u g h p e r i p h e r a l PYY/Y1 r e c e p t o r s i n a n e s t h e t i z e d rats. (Abstract# G0701) K Kawakubo, H Yang, H W0ng, V Wu, G Ohning and Y TachS. Los Angeles, CA

R e g u l a t i o n of superoxide a n i o n p r o d u c t i o n b y gastric surface e p i t h e l i a l cells i n c u l t u r e . (Abstract# GU08) K Rokutan, S Teshima, T Nikawa and K Kishi. Tokushima, Japan

I n d u c i b l e types of cyclooxygenase a n d n i t r i c oxide s y n t h a s e i n a d a p t i v e c y t o p r o t e c t i o n i n r a t stomachs. (Abstract# G1375) H Yamam0to, T Hirata, Y Sugawa, S Kato and K Takeuchi. Ky0to, Japan

P r i m a r y c u l t u r e s of g u i n e a p i g gastric surface epithelial cells release a b u n d a n t s u p e r oxide a n i o n t h r o u g h a m e m b r a n e - b o u n d NADPH-oxidase-like system. (Abstract# G1263) S Teshima, K Rokutan, T Nikawa and K Kishi. Tokushima, Japan

A r a t n o r m a l gastric surface m u c o u s cell line (RGM-1) m o n o l a y e r as a n excellent in ~itro model for s t u d y i n g gastric m u c o s a l b a r r i e r f u n c t i o n s . (Abstract# G1384) A Yanaka, H Suzuki, H Matsui, M Muto, T Shibahara, Y Murata, H Matsui, A Nakahara and H Muto. Ibaraki, Japan

I m p l i c a t i o n of a g i n g on n i t r i c oxide s y n t h a s e activity i n the genesis of w a t e r i m m e r s i o n s t r e s s - i n d u c e d gastric lesions i n rats. (Abstract# G0612) Y Hisanaga, H Goto, T Arisawa, Y Niwa, K Tachi, T Watanabe, M Tsukamura, J Shibata, K Kamiya, T Odori, T Hayakawa and S Sugiyama. Nagoya and Gifu, Japan

A cDNA clone e n c o d i n g t h e c a r b o x y l - t e r m i n a l of pig gastric m u c i n reveals a cysteine-rich r e g i o n s i m i l a r to h u m a n MUC5AC. (Abstract# G1282) BS Turner, KR Bhaskar, M Hadz0poulou-Cladaras and JT LaMont. Boston, MA

In ~ t r o effects of e t h a n o l a n d cigarette smoke o n the

P r o t e c t i v e m e c h a n i s m of t e p r e n o n e i n the isolated v a s c u l a r l y p e r f u s e d r a t stomach. (Abstract# G0832) P Li, TM Chang and WY Chey. Rochester, NY

M e c h a n i s m s of cold e x p o s u r e - i n d u c e d gastric m u c o s a l lesions i n d i a b e t i c rats; role of acid, p e p s i n a n d loss of mucus. (Abstract# G0726) M Kinoshita, S Igarashi, T Shimazaki, M Jimbo, N Sait0, T Noto, K Okuyama and H Narita. Saitama, Japan

Nitrosothiol-based SNO-NSAIDs as novel a n t i i n f l a m m a t o r y analgesic d r u g s w i t h r e d u c e d g a s t r o i n t e s t i n a l toxicity. (Abstract# GU23) JK Saha, JD Schr0eder, L Chen, TE Shelekhin, Q Dong, DS Garvey, LG Letts and SW Tam. Bedford, MA Differential i n d u c t i o n a n d f u n c t i o n of heat shock p r o t e i n s i n r a t gastric m u c o s a r e g u l a t e d b y n e u r o p e p t i d e s . (Abstract# G1027) M Otaka, M Jin, S It0h, A Iwabuchi, H Sasahara, H Itoh, M Odashima, I Pacheco, Y Tashima and 0 Masamune. Akita, Japan

D D W Poster of Distinction: p H - d e p e n d e n t c o n f o r m a t i o n a l changes of m u c i n s : why t h e s t o m a c h h a s a gel a n d t h e g a l l b l a d d e r does not. (Abstract# G0341) X Cao, R Bansil, KR Bhaskar, BS Turner, JT LaMont and NH Afdhal. Boston, MA

D D W Poster of Distinction: O r g a n i z a t i o n of v o n W i l l e b r a n d d o m a i n s of the mouse

MucSAC gene is s i m i l a r to t h e s t r u c t u r e of the MUC2 s e c r e t o r y m u c i n . (Abstract# G0272) AE Bartman, LL Shekels and SB Ho. Minneapolis, MN ESOPHAGEAL, GASTRIC, AND DUODENAL DISORDERS - - MUCOSAL I N J U R Y AND REPAIR

D D W Poster of Distinction: The role of p h o s p h o l i p a s e A2 i n c a l c i u m - m e d i a t e d i n j u r y to r a t gastric m u c o s a l cells. (Abstract# G1262) BL Tepperman and BD Soper. London, Canada

s q u a m o u s e p i t h e l i u m of r a b b i t oral cavity. (Abstract# G0316) S B0r, C Caymaz-Bor, NA Tobey and RC Orlando. New Orleans, LA

D D W Poster of Distinction: F a s t i n g causes gastric m u c o s a l lesion t h r o u g h the r e d u c t i o n of m u c u s g l y c o p r o t e i n i n diabetic rats. (Abstract# G0725) M Kinoshita, S Igarashi, T Shimazaki, M Jimbo, N Saito, K Okuyama, E Kume and H Narita. Saitama, Japan Diabetes: i n d u c t i o n of E G F R t y r o s i n e k i n a s e activity i n the gastric mucosa. (Abstract# G0710) A Khan, L Liu, Y Yu and APN Majumdar. Detroit, MI Mucosal b a r r i e r d i s r u p t i o n i n the gastric f l u i d a c c u m u l a t i o n of sepsis. (Abstract# G0417) EJ Dial, K Randall, J Romero and L Lichtenberger. Houston, TX Role of i r o n a n d lipid p e r o x i d a t i o n i n m e d i a t i n g p e r o x y n i t r i t e - i n d u c e d toxicity to c u l t u r e d gastric mucosal cells. (Abstract# Gl137) T Sasai, H Hiraishi, T Oinuma, T Shimada and A Terano. Tochigi, Japan

D D W Poster of Distinction: Rat gastric i s c h e m i a / r e p e r f u s i o n i n j u r y : role of n i t r i c oxide a n d r e l a t i o n to cyclooxygenase (COX)-1 a n d COX2. (Abstract# G0884) N Maricic, K Ehrlich, M Respondek and BM Peskar. B0chum, Germany

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DDW Poster of Distinction: Effects of l a f u t i d i n e , a n o v e l h i s t a m i n e H2-receptor a n t a g o n i s t , o n g a s t r o i n t e s t i n a l lesions i n rats: r e l a t i o n to c a p s a i c i n s e n s i t i v e s e n s o r y n e u r o n s . (Abstract# G1259) K Tashima, A Konaka, Y Sugawa, S Kato and K Takeuchi. Kyoto, Japan

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17, 1998

E a r l y p h a s e of gastric e p i t h e l i a l cell m i g r a t i o n : d i s t r i b u t i o n of m i c r o f d a m e n t s a n d focal a d h e s i o n s i n calcium-depleted gastric cell culture: a confocal microscopic study. (Abstract# G0730) T Kivilu0to, M Lax, E Lehtonen, T Ranta-Knuuttfla, S Watanabe, N Sato, E Kivflaakso and P Pu01akkainen. Helsinki, Finland and Tokyo, Japan

Effects of c a p s a i c i n o n s t r e s s - i n d u c e d d u o d e n a l i n j u r y . (Abstract# G1095) J Ren, Y Xia, H Ojeas, L Qian, S Lightfoot, M Kida and R Harry. Oklahoma City, OK

IGF-I, a n d its a n a l o g u e peptide, LRSIGF-I, a r e e q u i p o t e n t at a c c e l e r a t i n g i n t e s t i n a l r e g r o w t h following a b d o m i n a l i r r a d i a t i o n . (Abstract# G0629) GS Howarth, R Fraser, C Frisby, M Schirmer and E Yeoh. North Adelaide and Adelaide, Australia

Decreased g a s t r o i n t e s t i n a l i n j u r y following short d u r a t i o n i n t r a - a r t e r i a l c h e m o t h e r a p y for m e t a s t a t i c liver disease. (Abstract# G1320) F Vashi, F Sirijintakaran and B Tan. Zion, IL

Factors affecting pS2 gene e x p r e s s i o n i n g a s t r i c epithelial cells. (Abstract# Gl172) T Shimada, K Sakata, N Watanabe, M Endoh, Y Ohtsuka, H Hiraishi and A Terano. T0chigi, Japan

E t h a n o l i n j u r y t r i g g e r s a c t i v a t i o n of a d r e n o m e d u l l i n a n d its r e c e p t o r genes i n gastric m u c o s a b o r d e r i n g necrosis: a key to m u c o s a l r e p a i r ? (Abstract# G1338) H Wang, M Tomikawa, IJ Sarfeh and A Tarnawskl. Long Beach and Irvine, CA

Sodium salicylate activates the t r a n s c r i p t i o n factor NFKB a n d u p r e g u l a t e s i n t e r l e u k i n - 8 e x p r e s s i o n i n gastric epithelial cells. (Abstract# Gl173) T Shimada, N Watanabe, M Endoh, Y Ohtsuka, H Hiraishi and A Terano. Tochigi, Japan

A c t i v a t i o n of VEGF a n d Ras genes i n gastric m u c o s a d u r i n g a n g i o g e n i c r e s p o n s e to e t h a n o l i n j u r y . (Abstract# G0665) MK Jones, RM Itani, M Tomikawa, IJ Sarfeh and AS Tarnawski. Long Beach and Irvine, CA S t i m u l a t i o n of i n v/fro r e s t i t u t i o n b y t y r o s i n e p h o s p h a t a s e i n h i b i t i o n . (Abstract# G0927) JE Meyer, LEtter, MA Sanders, NJ Emenaker and MD Basson. New Haven and West Haven, CT I n f l u e n c e of m o n o c l d o r a m i n e o n h e a l i n g of acute gastric m u c o s a l l e s i o n s i n rats: beneficial effects of polaprezinc. (Abstract# G1213) Y Sugawa, H Nishiwaki, S Kato, T Yoneta and K Takeuchi. Kyot0, Japan E p i t h e l i a l i z a t i o n s t i m u l a n t s i n d u c e expression of v a s c u l a r e n d o t h e l i a l g r o w t h factor i n h u m a n gastric epithelial cells i n p r i m a r y culture. (Abstract# G1237) M Takahashi, K Ogura, S Maeda, Y Hata, T Kawabe, Y Shirat0ri and M Omata. Tokyo, Japan Role of gap j u n c t i o n a l c o m m u n i c a t i o n i n r e s t i t u t i o n of r a t gastric mucosa. (Abstract# G1238) N Takahashi, T Joh, K Seno, K Watanabe, K Tsuchida, Y Yok0yama, K Mimura, F Ueda and M It0h. Nagoya and Kyoto, Japan T y r o s i n e p h o s p h o r y l a t i o n after superficial i n j u r y i n isolated g u i n e a pig g a s t r i c epithelium. (Abstract# G0297) A Bhowmik, H Paimela, R Roivainen, J Koistinaho, T J0utsi and E Kivilaakso. Helsinki and Kuopio, Finland Effects of l u m i n a l a n d / o r serosal a m m o n i a on p r o t e c t i o n a n d r e p a i r of g u i n e a pig gastric m u c o s a i n v/tro. (Abstract# G1221) H Suzuki, A Yanaka, M Muto, T Shibahara, Y Murata, H Matsui, A Nakahara and H Muto. Ibaraki, Japan R a t GRO/CINC-1, a m e m b e r of CXC chemokine, h a s a g r o w t h - s t i m u l a t i n g a c t i v i t y for r a t gastric epithelial cells. (Abstract# G1224) H Suzuki, M Mori, K Seto, F Shibata, M Suzuki, S Miura, K Watanabe and H Ishii. Tokyo, Japan

C a l c i u m / c a l m o d u l i n d e p e n d e n t p a t h w a y p l a y s a second m e s s e n g e r role i n signal t r a n s d u c t i o n of m i g r a t i o n i n c u l t u r e d gastric e p i t h e l i a l cells. (Abstract# G1088) T Ranta-Knuuttila, P Puolakkainen, T Kiviluoto, S Watanabe, N Sato and E Kivilaakso. Helsinki, Finland and Tokyo, Japan E x t r a c e l l u l a r m a t r i x factors l a m i n i n , f i b r o n e c t i n a n d collagen IV m o d u l a t e t h e adhesion, r e s t i t u t i o n a n d p r o l i f e r a t i o n of r a t i n t e s t i n a l epithelial cells. (Abstract# G0423) AU Dignass, A Becker and H Goebell. Essen, Germany ESOPHAGEAL, GASTRIC, AND D U O D E N A L DISORDERS - - U L C E R H E A L I N G Roles of n e u t r o p h i l a n d its a d h e s i o n molecules i n the d e v e l o p m e n t of gastric u l c e r i n d u c e d b y s u b m u c o s a l i n j e c t i o n of endothelin-1 i n rats. (Abstract# G1342) T Watanabe, T Arakawa, T Fukuda, K Tominaga, Y Fujiwara, K Higuchi, O Takaishi, K Yamasaki, K K0bayashi and T Kur0ki. Osaka, Japan I n h i b i t i o n of gastric acid s e c r e t i o n b y omeprazole p r e v e n t s gastric u l c e r r e l a p s e c a u s e d b y i n t e r l e u k i n - l ~ i n rats. (Abstract# G1341) T Watanabe, T Arakawa, T Fukuda, K Higuchi, Y Fujiwara, O Takaishi, K Yamasaki, K K0bayashi and T Kur0kl. Osaka, Japan Opposite actions of female sex steroids o n cysteaminei n d u c e d g a s t r o d u o d e n a l u l c e r a t i o n i n the rat. (Abstract# G0804) F L~iszlS, C Montoneri and F Drago. Szeged, Hungary and Catania, Italy Talcid activates genes e n c o d i n g for e p i d e r m a l growth factor, its r e c e p t o r a n d ErbB-2 i n h u m a n g a s t r i c epithelial cells. (Abstract# G1257) A Tarnawskl, R Itani, R Pai and IJ Sarfeh. Long Beach and Irvine, CA Localization of cyclooxygenase-2 a n d regulatiQn of its e x p r e s s i o n i n gastric ulcers i n rats. (Abstract# G1242) S Takahashi, J-i Shigeta, N K0bayashi and S Okabe. Ky0to, Japan Role of i n t e r l e u k i n - 1 i n t h e h e a l i n g of g a s t r i c ulcers i n rats. (Abstract# G1243) S Takahashi, E Nakamura, M Yokota and S Okahe. Kyoto, Japan

April 1998

P R O G R A M OF T H E ANNUAL M E E T I N G P25

A G A P O S T E R S E S S I O N - - S U N D A Y , M A Y 17, 1 9 9 8 C h a n g e s of n i t r i c oxide a n d g r o w t h factors associated w i t h t h e g a s t r i c m u c o s a l m i c r o c i r c u l a t i o n i n process of gastric u l c e r h e a l i n g . (Abstract# G0216) M Akimoto, H Hashimoto, A Maeda, M Shigemoto, Y Yamashita and I Yokoyama. Tokyo, Japan E p i d e r m a l g r o w t h factor accelerates e x p e r i m e n t a l gastric u l c e r h e a l i n g b y d e c r e a s i n g b a c t e r i a l colonization. (Abstract# G0464) SN Elliott, W McKnight, JA Hardin, ME Olson, DG Gall, JL Wallace and A Buret. Calgary, Canada T r o p h i c role of CCK B-gastrin receptors i n i n t a c t a n d u l c e r a t e d o x y n t i c m u c o s a i n rats. (Abstract# GU48) A Schmassmann, P Schuchert, B Flogerzi and F Halter. Bern, Switzerland C h a n g e s i n gene e x p r e s s i o n d u r i n g gastric u l c e r h e a l i n g i n rats. (Abstract# GUS0) P Schuchert, A Etter, B Flogerzi, F Halter and A Schmassmann. Bern, Switzerland Myofibroblast a t t r a c t s n e u r o f i l a m e n t - p o s i t i v e r e g e n e r a t e d n e r v e fibers to gastric m u c o s a after acetic a c i d - i n d u c e d g a s t r i c m u c o s a l i n j u r y . (Abstract# G0980) M Nakamura, H Kishikawa, M Oda and H Ishii. Tokyo, Japan E x p r e s s i o n of ETS-1 t r a n s c r i p t i o n factor i n r e l a t i o n to a n g i o g e n e s i s i n h e a l i n g process of gastric ulcer. (Abstract# G0649) M Ito, T Nakayama, S Naito, M Matuu, K Shichijo and I Sekine. Nagasaki, Japan Effects of a n t i - u l c e r d r u g s o n gastric mucosal e x p r e s s i o n of cyclooxygenase-2 i n rats. (Abstract# G1281) S Tsuji, WH Sun, H Sawaoka, M Tsujii, H Murata, H Iijima, S Kawano and M Hori. Suita, Japan

DDW Poster of Distinction: D r u g - i n d u c e d g a s t r i c ulcers are caused b y more t h a n j u s t NSAIDs: a l e n d r o n a t e gastric ulcers. (Abstract# G0564) DY Graham and HM Malaty. Houston, TX R e d u c t i o n of E G F is associated w i t h the delay of gastric u l c e r h e a l i n g b y cigarette smoke i n rats. (Abstract# G0854) L Ma, JYC Chow, ST Yuen and CH Cho. Hong Kong, China Role of p a n c r e a t i c secretory t r y p s i n i n h i b i t o r i n h e a l i n g of c h r o n i c gastric ulcers i n rats. (Abstract# G3646) PC Konturek, T Brzozowski, SJ Konturek, S Yagi, G Ella and EG Hahn. Erlangen, Germany; Krakow, Poland and Shionogi, Japan

Effectiveness of l a n s o p r a z o l e i n t h e h e a l i n g of NSAIDi n d u c e d gastric u l c e r i n p a t i e n t s c o n t i n u i n g to take NSAIDs. (Abstract# G0213) N Agrawal, M Safdi, L Wruble, D Karvois, P Greski-Rose and B Huang. Farmington, CT; Cincinnati, OH; Memphis, TN; Deerfield and Abbott Park, IL P r e v e n t i o n of a c u t e NSAID-related g a s t r o d u o d e n a l damage: a m e t a - a n a l y s i s of c o n t r o l l e d clinical t r i a l s . (Abstract# G0808) G Leandro, A Pilotto, T Bertin, M Franceschi and G Valerio. Vicenza, Italy and Castellana Grotte, Italy Diclofenac/misoprostol v e r s u s P P I p r o p h y l a x i s i n the p r e v e n t i o n of NSAID-induced complications: a cost model comparison. (Abstract# G0554) JL Goldstein, BD Yamashita and LR Larson. Chicago and Highland Park, IL

DDW Poster of Distinction: U s i n g sucrose p e r m e a b i l i t y to s c r e e n for a s y m p t o m a t i c NSAID-induced lesions: c a n we s t o m a c h the costs? (Abstract# G0858) K Madala, J Gregor, DA Lloyd and D Bondy. London, Canada Fecal calprotectin: a simple m e t h o d for the diagnosis of NSAID-induced e n t e r o p a t h y . (Abstract# G1269) JA Tibble, R Foster, G Sigthorsson, D Scott, A Roseth and I Bjarnason. London, United Kingdom Nimesulide, a selective COX-2 i n h i b i t o r , causes less gastrointestinal damage compared with naproxen: a prospective s t u d y i n h u m a n v o l u n t e e r s . (Abstract# GU61) AA Shah, FE Murray, B Thjodleifsson, E Oddsson, H Gudjonsson, DJ Fitzgerald and I Bjarnason. Dublin, Ireland; Reykjavik, Iceland and London, United Kingdom Ulcer i n c i d e n c e is l i n e a r over time i n p a t i e n t s t r e a t e d w i t h n a b u m e t o n e for over 5 years. (Abstract# G1037) RH Palmer, MP Poland and RE DeLapp. Collegeville, PA Mechanisms i n v o l v e d i n the d e v e l o p m e n t of dyspeptic s y m p t o m s d u r i n g t r e a t m e n t w i t h a s p i r i n . (Abstract# G0619) G Holtmann, J Neufang-H~iber, A Kaune, H Goebell and NJ Talley. Essen, Germany and Sydney, Australia M i c r o e n c a p s u l a t e d a s p i r i n , Asacard, r e d u c e s endoscopic d a m a g e i n h e a l t h y v o l u n t e e r s c o m p a r e d to c o n v e n t i o n a l e n c a p s u l a t e d a s p i r i n . (Abstract# G0440) MT Donnelly, WA Stack, P Richardson, EM Courtauld, LM Allan, PS Kiff and CJ Hawkey. Nottingham, United Kingdom

DDW Poster of Distinction: A c t i v a t i o n of genes for r a t spasmolytic p e p t i d e a n d t r a n s f o r m i n g g r o w t h factor-a d u r i n g a d a p t a t i o n to a s p i r i n i n j u r y . (Abstract# G3645) PC Konturek, T Brzozowski, SJ Konturek, P Pierzchalski, S Kwiecien and EG Hahn. Erlangen, Germany and Krakow, Poland ESOPHAGEAL, GASTRIC, AND DUODENAL DISORDERS - - NSAIDS: CLINICAL ASPECTS P a n t o p r a z o l e v e r s u s placebo i n p r e v e n t i o n of NSAIDi n d u c e d ulcers. (Abstract# G0298) G Bianchi Porto, V Imbesi, M Lazzaroni, F Montrone and T Santagada. Milan and Cormano, Italy

Nitric oxide d o n a t i n g f i u r b i p r o f e n (HCT 1026) causes less endoscopic d a m a g e i n h e a l t h y v o l u n t e e r s t h a n flurbiprofen. (Abstract# G0441) MT Donnelly, WA Stack, EM C0urtauld, N Garlick, P Del Soldato and CJ Hawkey. Nottingham, United Kingdom and PariS, France

Hellcobacterpylori e r a d i c a t i o n a n d u l c e r h e a l i n g i n p a t i e n t s on long t e r m n o n - s t e r o i d a l a n t i i n f l a m m a t o r y drugs. (Abstract# G0478) G Etolhi, JB Dawodu, QB Zhang, E Graham and RI Russell. Glasgow, Scotland

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GASTROENTEROLOGY

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Vol.114rNo.4

179 1 9 9 8

C a n e r a d i c a t i o n of Helicobacterpylorl p r e v e n t f u t u r e d e v e l o p m e n t of p e p t i c ulcers i n p a t i e n t s r e c e i v i n g l o n g t e r m c o n t i n u o u s n o n s t e r o i d a l a n t i i n f l a m m a t o r y drugs? (Abstract# G0787) KC Lai, SK Lam, WM Hui, BCY Wong, CS Lau, WHC Hu and ZF Wen. Hong Kong, PR China

P h o s p h o d i e s t e r a s e 4 i n h i b i t i o n , a n e w m e c h a n i s m to m a i n t a i n a n d p r o m o t e gastric a n d i n t e s t i n a l m u c o s a l i n t e g r i t y a g a i n s t NSAID-induced i n j u r y i n t h e rat. (Abstract# GU26) C Salcedo, J Puig, JM Palacios and AG Fernandez. Barcelona, Spain

I n f l u e n c e of sex a n d Helicobaeterpylorl o n type a n d l o c a t i o n of lesions i n NSAID users. (Abstract# G0595) CJ Hawkey, AJ Swannell, J Maesdal, A Walan and ND Yeomans. Nottingham, United Kingdom; M~lndal, Sweden and Melbourne, Australia

M e c h a n i s m s of a s p i r i n - m e d i a t e d PGHS-2 gene induction in a human intestinal subepithelial myofibroblast cell line. (Abstract# G0934) RC Mifflin, JI Saada, JF DiMari, JD Valentich and DW Powell. Galveston, TX

F a i l u r e of Helieobaeterpjrlorl e r a d i c a t i o n to i n f l u e n c e site-specific r e l a p s e i n h i g h r i s k NSAID users: r e s u l t s of a large six m o n t h d o u b l e - b l i n d r a n d o m i z e d c o n t r o l l e d clinical trial. (Abstract# G0594) CJ Hawkey, Z Tulassay, L Szcepanski, CJ van Rensburg, A Filipowicz-Sosnowska, A Lanas, RA Peacock and KRW Gillon. Nottingham, United Kingdom and Edinburgh, Scotland; Budapest, Hungary; Lublin and Warsaw, Poland; Tygerberg, South Africa and Zaragoza, Spain

DDW Poster of Distinction:

DDW Poster of Distinction: Effect of H. py-lori s t a t u s o n h e a l i n g of gastric ulcer i n p a t i e n t s c o n t i n u i n g to t a k e NSAIDs a n d t r e a t e d with l a n s o p r a z o l e or r a n i t i d i n e . (Abstract# G0339) DR Campbell, N Shah, B Winston, D Karvois and P GreskiRose. Kansas City, MO; Hollywood, MD; Houston, TX; Deerfield and Abbott Park, IL N o n s t e r o i d a l a n t i i n f l a m m a t o r y d r u g s could r e v e r s e Helicobaeterpylori-induced i m b a l a n c e b e t w e e n p r o l i f e r a t i o n a n d apoptosis i n gastric epithelial cells. (Abstract# G1411) GH Zhu, XL Yang, KC Lai, CK Ching, BCY Wong, WM Hui, ST Yuen, J Ho and SK Lam. Hong Kong, China ESOPHAGEAL, GASTRIC, AND DUODENAL DISORDERS - - NSAIDS: BASIC M E C H A N I S M S

DDW Poster of Distinction: I n d u c t i o n of cyclooxygenase-2 i n r a t gastric epithelial cells b y EGF, e p i r e g u l i n a n d bFGF. (Abstract# GU38) E Sasaki, R Pal, T Komurasaki, T Arakawa, K Kobayashi, T Kuroki, IJ Sarfeh and AS Tarnawski. Long Beach and Irvine, CA; Osaka and Tokyo, Japan Role of cyclooxygenase-1 a n d cyclooxygenase-2 d e r i v e d prostagiandins in adaptive cytoprotection induced by m i l d stress. (Abstract# G0335) T Brzozowski, PC Konturek, R Pajdo, N Nagraba, A Szczeklik and SJ Konturek. Krakow, Poland and Erlangen, Germany A g g r a v a t i o n of i n d o m e t h a c i n - i n d u c e d gastric mucosal lesions i n a d j u v a n t a r t h r i t i c rats. (Abstract# G0694) S Kato, A Tanaka, A Konaka and K Takeuchi. Kyoto, Japan

II

Targeted d i s r u p t i o n of E-, P- a n d L-selectin l i g a n d b i o s y n t h e s i s is associated with a decrease i n susceptibility to i n d o m e t h a c i n - i n d u c e d i n t e s t i n a l damage. (Abstract# G0284) PL Beck, RJ Xavier, N Lu, DK Podolsky and B Seed. Boston, MA Calcium c h a n n e l blockers a t t e n u a t e d i c l o f e n a c - i n d u c e d small i n t e s t i n a l ulceration. (Abstract# G0253) A Balakumaran, C Atchison, AB West, W Hoffman and M Treinen-Moslen. Urbana, IL and Galveston, TX I m p a i r e d colonic b a r r i e r f u n c t i o n after p a r e n t e r a l NSAIDs. (Abstract# G0845) A Lugea, F Guarner and J-R Malagelada. Barcelona, Spain ESOPHAGEAL, GASTRIC, AND D U O D E N A L DISORDERS q HELICOBACTER PYLORI: EPIDEMIOLOGY AND NATURAL HISTORY Association b e t w e e n subjects w i t h dyspeptic s y m p t o m s a n d Helieobaeterpyloriinfection: epidemiologic s t u d y c o n d u c t e d at 16 centers i n A r g e n t i n a . (Abstract# G1016) JA Olmos, R Higa, H Rios, LO Soifer, JA De Paula, R Pedrana, N Chopita, 0 Gadea, J Katz, J Adami and E Varela. Buenos Aires, Argentina Smoking h a s a n additive deleterious effect o n g a s t r o d u o d e n a l pathology a n d t h e clinical c o u r s e i n H. pyloripositive dyspeptic p a t i e n t s . (Abstract# G0965) M Moshkowitz, FM Konikoff, S BriU, M Averbuch and Z Halpern. Tel Aviv, Israel

H. pylori serology is u n h e l p f u l i n the m a n a g e m e n t of African p a t i e n t s w i t h dyspepsia. (Abstract# G1015) SJD O'Keefe, J Nainkin, B Salvador, S Majiki, H Stevens and A Atherstone. Mdantsane, South Africa Helleobaeterpylorl a n t i b o d y r e s p o n s i v e n e s s a n d p r e v a l e n c e of gastric c a n c e r a m o n g 10,000 c o n s e c u t i v e endoscoped J a p a n e s e i n d i v i d u a l s . (Abstract# G1374) Y Yamaji, H Ijichi, J Kato, T Ikenoue, S Maeda, K Ogura, M Okamoto, M Takahashi, H ¥oshida, T Kawabe, Y Shiratori, N Toda, H Ikuma, K Nagatani, K Yokouchi, T Mitsushima and M Omata. Tokyo, Kamogawa and Chiba, Japan

E x t r a v i r g i n olive oil-enriched diets p r o t e c t s the NSAID-induced gastric d a m a g e i n rats: role of leukocyte a d h e r e n c e . (Abstract# G0269) MD Barranco, C Alarc6n de la Lastra, V Motilva, MJ Martin, S Garcia-Maurifio, V Sfinchez-Margalet, J Esteban and JM Herrerlas. Sevilla, Spain

P r e v a l e n c e a n d r i s k factors of ttelieobaeterpylori infection i n different r e g i o n s of F r a n c e . (Abstract# G0329) N Broutot, AM Sarasqueta, F Cantot, D Lethuaire and F M6graud. Bordeaux and Gentilly, France

I n d o m e t h a c i n i n c r e a s e s s u s c e p t i b i l i t y to i n j u r y i n h u m a n gastric cells i n d e p e n d e n t of p r o s t a g l a n d i n s y n t h e s i s i n h i b i t i o n . (Abstract# G0752) ER Kokoska, GS Smith, Y Deshpande, AB Wolff and TA Miller. St Louis, MO

Adult-to-child t r a n s m i s s i o n of Helieobaeterpylorl infection: r e s u l t s from 8-year b i r t h cohort study. (Abstract# G0867) HM Malaty, DY Graham, T Kumagai, S Hosogaya, K Misawa, K Furihata, H Ota, C Sei, E Tanaka, T Akamatsu, T Shimzu, K Kiyosawa and T Katsuyama. Houston, TX and Matsumoto, Japan

April1998

PROGRAMOF THEANNUALMEETINGP27

A G A P O S T E R S E S S I O N - - S U N D A Y , M A Y 17, 1998 Helieobaeterpylori i n f e c t i o n i n preschool a n d s c h o o l age c h i l d r e n : effect of race a n d e n v i r o n m e n t . (Abstract# G0866) HM Malaty and DY Graham. Houston, TX A c q u i s i t i o n a n d loss of Helicobacterpyloriinfection i n Japan: r e s u l t s from a n 8-year b i r t h cohort study. (Abstract# G0779) T Kumagai, S Hosogaya, K Misawa, K Furihata, H Ota, C Sei, E Tanaka, T Akamatsu, T Shimizu, K Kiyosawa, T Katsuyama, HM Malaty and DY Graham. Matsumoto, Japan and Houston, TX

Suggestion a g a i n s t a n oro-oral r o u t e of t r a n s m i s s i o n for Helicobaeterpyloriinfection. A seroepidemiological s t u d y i n a r u r a l area. (Abstract# G0851) F Luzza, M Imeneo, M Maletta, G Paluccio, S Nistic5, M Costa, F Perticone, C Cavaliere, A Foc~ and F Pallone. Catanzaro, Italy The p r e v a l e n c e of Hellcobavterpylori infection is n o t i n c r e a s e d i n c h i l d r e n with celiac disease. (Abstract# G0852) F Luzza, M Mancuso, M Imeneo, L Mesuraca, A Contaldo, L Pensabene, G Scozia, P Strisciuglio, S Guandalini and F Pallone. Catanzaro, Italy

S i g n i f i c a n t differences i n p r e v a l e n c e of Hel/cobacter pyloriinfection b e t w e e n c h i l d r e n w i t h nonspecific

DDW Poster of Distinction:

recurrent abdominal pain and healthy asymptomatic school c h i l d r e n . (Abstract# G1392) CK Yeung, HN Chin, JJY Sung and SSC Chung. Hong Kong, PR China

A n i m a l r e s e r v o i r s i n the t r a n s m i s s i o n of Helieobaeter heilmmlnii;, r e s u l t s of a q u e s t i o n n a i r e - b a s e d study. (Abstract# G0916) A Meining, G Kroher and M Stolte. Bayreuth, Germany

DDW Poster of Distinction: Acute H. pyloriinfection is e l i m i n a t e d s p o n t a n e o u s l y

Pilot s t u d y of H. pylori a n d w a t e r u s e i n Chiapas, Mexico. (Abstract# G0273) B Bartos, D Halperin, L Sanchez and J Parsonnet. Stanford, CA and San Cristobal de las Casas, Mexico

w i t h o u t a n t i m i c r o b i a l t r e a t m e n t i n p a t i e n t s w i t h acute gastric m u c o s a l lesions. (Abstract# G1009) S Ohara, H Sekine, K Iijima, T Koike, K Kato, T Arikawa and T Toyota. Sendal, Japan A m u l t i p l e - s i t e i n v e s t i g a t i o n of seropositivity for Helieobacterpyloriin c h i l d r e n of the U.S. (Abstract# G0375) SKF Chong, QY Lou, S Rabinowitz, R Jibaly, V Tolia, A Rosenberg, Y Elitsur, A Johnson, O Elkayam, P Rosenthal, BK Li, B Gold, M Gflger, M Hodik and JS Peacock. Indianapolis, IN The a s s o c i a t i o n b e t w e e n anti-CagA serological r e s p o n s e a n d p r e c a n c e r o u s lesions i n Helicobavter pylori-carrying subjects i n China. (Abstract# G0993) EKW Ng, WK Leung, SR Lin, JY Sung, JYL Ching, KF To, LY Zhou, RT Wang, W Chao and SCS Chung. Hong Kong and Beijing, PR China The role of Helicobacterpyloriin p e r f o r a t e d d u o d e n a l ulcer: a p r o s p e c t i v e r a n d o m i z e d t r e a t m e n t trial. (Abstract# G0994) EKW Ng, MY Yung, YH Lain, DWH Lee, BKB Law, ACW Chan, JYW Lau, TKW Ling, JY Sung, WY Lau and SCS Chung. Hong Kong, PR China

Hellcobaeterpylorl s t a t u s of p a t i e n t s on c h r o n i c acid s u p p r e s s i o n for p e p t i c u l c e r disease or ulcer-like symptoms. (Abstract# G0221) J Allison, R Hiatt, T Levin, T Lieu, L Ackerson, D Libran and LHurley. Oakland, CA E v a l u a t i o n of Helivobaeterpyloriinfection a n d cagA e x p r e s s i o n i n a n a r e a w i t h a low f r e q u e n c y of gastric cancer. (Abstract# G0204) MR Abbolito, F Citarda, N Figura, R Giannace, S Petreni, V Stigliano, GM Gandolfo and M Crespi. Rome and Siena, Italy

DDW Poster of Distinction: I s o l a t i o n of H. pylorifrom v o m i t u s i n children. (Abstract# G0826) WK Leung, JY Sung, KLK Sin, KL Kwok, AFB Cheng and R Sung. Hong Kong, China Can pets act as vector for tleh'cobacterpylori t r a n s m i s s i o n ? (Abstract# G0943) P Moayyedi, D Braunholtz, M Liptrot, W Crocombe, IDG Richards and ATR Axon. Leeds, United Kingdom

Acute gastric m u c o s a l lesions c a u s e d b y Helicobacter pyloriinfection after endoscopy. (Abstract# G0609) N Hirahara, T Moriai, S Okamoto, Y Morita, T Sato and I Makino. Hokkaido, Japan I n t e r m e d i a t e H. pylori (Hp) s e r o p r e v a l e n c e rates i n C a n a d i a n I n u i t , despite d e t e c t i o n of Hp DNA from local water. (Abstract# G0912) I Mckeown, POrr, A Kabani, J Embfl, M Dawood, G Coghlan, G Smart, S Macdonald, M Sargent and CN Bernstein. Winnipeg, Canada Analysis of t h e t r a n s m i s s i o n of H. pyloriin childhood. (Abstract# G0941) H Miyaji, T Azuma, S Ito, H Suto, Y Ito, Y Yamazaki, Y Abe, M Kuriyama and Y Kohli. Fukui and Kyoto, Japan Anti-secretory d r u g s i n c r e a s e c o r p u s gastritis b u t only i n the p r e s e n c e of Helieobaeterpy]oriinfection. (Abstract# G1370) HH-X Xia, J Kalantar, GD Eslick, JM Wyatt, S Adams, K Cheung and NJ Talley. Sydney, Australia C h r o n i c corpus gastritis is p r o t e c t i v e a g a i n s t erosive esophagitis. (Abstract# G0465) HB E1-Serag, A Sonnenberg, MM Jamal, JM Inadomi and RM Feddersen. Albuquerque, NM Prospective e v a l u a t i o n of c a r d i a i n t e s t i n a l m e t a p l a s i a : c o r r e l a t i o n to H. pyloristatus. (Abstract# G1348) AP Weston, AS Badr, PT Krmpotich, M Topalovski, R Cherian and A Dixon. Kansas City, MO a n d Kansas City, KS Should the Helicobacter r e a l l y be saved? HP's p u t a t i v e p r o t e c t i o n a g a i n s t GERD m a y be associated w i t h a n i n c r e a s e d r i s k of gastric p r e n e o p l a s t i c lesions. (Abstract# G0406) E De Koster, C Deprez, M Buset and M Deltenre. Brussels, Belgium What causes gastric a n d d u o d e n a l u l c e r s i n c h i l d r e n i n t h e H. pyloriera? (Abstract# GU90) JD Snyder, O Elkayam, MB Heyman and L Ferrell. San Francisco, CA

P28 PROGRAMOF THEANNUALMEETING

A p o p u l a t i o n b a s e d s t u d y of Hellcobaeterpylo~ infection. V: excess 8 13CO2e x c r e t i o n as a n i n d i c a t o r of b a c t e r i a l load is associated w i t h d e m o g r a p h i c a n d i n d i v i d u a l factors. (Abstract# G0280) F Bazzoli, RM Zagari, D Palli, D Festi, P P0zzato, G Masala, S Sottili, D Panuccio, L Ricciardiello, G Nicolini, S Fossi, E Edili, P Simoni, A Roda and E Roda. Bologna, Chieti and Florence, Italy Usefulness of a d d i n g the d e t e r m i n a t i o n of Helieobaeter pylori-CagA to a pre-endoscopic s c r e e n i n g policy. (Abstract# G0922) M Menegatti, D Vaira, G. Masala, D Palli, M Miglioli and the Italian Helicobacter pylori Study Group. Bologna and Florence, Italy P r e v a l e n c e of Helleobaeterpylori CagA: cross-sectional s t u d y i n 1452 p a t i e n t s t h r o u g h Italy. (Abstract# G0921) M Menegatti, D Palli, M Miglioli, C Saieva, D Vaira and the Italian Helicobacter pylori Study Group. Bologna and Florence, Italy Profession, s o m a t o m e t r i c c h a r a c t e r i s t i c s a n d f a s t i n g s e r u m g a s t r i n i n p a t i e n t s w i t h d u o d e n a l ulcer; r e l a t i o n s h i p to t h e H. pylord status. (Abstract# G0236) A Archimandritis, D Kalogeras, M Chronaki, N Toupadaki and M Tzivras. Athens, Greece IgA deficiency does n o t p r e d i s p o s e to H. pylori infection. (Abstract# G0962) D Morton, R Munks, RJ Sokol and KD Bardhan. Rotherham and Sheffield, United Kingdom The s e r o p r e v a l e n c e of Helieobacterpyloriin UK blood d o n o r s - a story of t o w n a n d c o u n t r y . (Abstract# G0964) D Morton, RJ Sokol, MA Chapman and KD Bardhan. Rotherham and Sheffield, United Kingdom Is t h e r e a n y t h i n g to the r e p o r t e d association b e t w e e n Helicobaeterpylorlinfection a n d diabetes mellitus? (Abstract# G0300) M Bilotta, A Pacifico, MP Dore, G Pisanu, M Maioli, G Realdi, HM Malaty and DY Graham. Sassari, Italy and Houston, TX R e l a t i o n s h i p b e t w e e n s e r o p o s i t i v i t y for Helleobaeter pylo~, CagA status, a n d AIDS. (Abstract# G0910) CC McGowan, AS Necheva, GI Perez-Perez, MJ Blaser, CJ Dart and DW Haas. Nashville, TN and Abbott Park, IL Low p r e v a l e n c e of Helivobaeterpylori a n d high p r e v a l e n c e of NSAID use i n a n A u s t r a l i a n d u o d e n a l u l c e r p o p u l a t i o n . (Abstract# G0608) A Henry and R Batey. Newcastle, Australia

Helicobacter pyloriinfection does n o t affect r e d blood cell c h a r a c t e r i s t i c s i n D a n i s h adults. (Abstract# Gl111) S Rosenstock, N Milman, T Jcrgensen, LP Andersen and O Bonnevie. Copenhagen, Denmark

Helicobacterpylorireinfection a n d u l c e r r e c u r r e n c e i n c h i l d r e n following e r a d i c a t i o n t h e r a p y . (Abstract# G0695) S Kato, D Abukawa, N Furuyama and K Iinuma. Sendai, Japan Does Helicobaeterpyloriinfection e r a d i c a t i o n modify peptic u l c e r p r e v a l e n c e ? (Abstract# G0425) F Di Mario, M Molaro, N Dal B5, S Salandin, A Buda, F Vianello, S Kusstatscher, G Battaglia, A Pilotto and S Vigneri. Padua, Palermo, Vicenza and Venice, Italy

GASTROENTEROLOGYVol.114r No. 4

R e c u r r e n c e of Helieobacterpylori i n f e c t i o n after e r a d i c a t i o n : i n c i d e n c e a n d v a r i a b l e s i n f l u e n c i n g it. (Abstract# G0543) JP Gisbert, JM Pajares, R Garcla-Valriberas, V Abraira, D Boixeda, R Garcia-Gr~ivalos, C Martin-de-Argila and A Garcia-Plaza. Madrid, Spain R e c u r r e n c e of H. pylori (HP) i n a d u l t s after successful e r a d i c a t i o n t h e r a p y i n a n area of h i g h H P p r e v a l e n c e (Bangladesh). (Abstract# Gl113) L Rossi, S Parvin, AK Azad Khan, P Hildebrand, C Beglinger and K Gyr. Dhaka, Bangladesh and Basel, Switzerland D u o d e n a l ulcer a n d Helieobaeterpylori: r e l a p s e a n d r e c u r r e n c e i n a long t e r m study. (Abstract# G0895) G Martino, M Paoletti, B Annibale, A Marcheggiano, M Marignani, I Luzi, G D'Ambra, C Iannoni, R Caprilli and G Delle Fare. Rome, Italy P r e v e n t i o n of d u o d e n a l ulcer r e c u r r e n c e following e r a d i c a t i o n of Helieobaeterpylori: a p r o s p e c t i v e 6 years study. (Abstract# G0255) V Balatsos, V Delis, Z Manika, N Skandalis and A Archimandritis. Athens, Greece Development of Helieobaeterpylorl.infected h u m a n a n t r a l p r i m a r y cell cultures. (Abstract# GU00) A Richter-Dahlfors, RM Meloche, B Finlay and AMJ Buchan. Vancouver, Canada

DDW Poster of Distinction: Overexpression of p53 p r o t e i n i n g a s t r i c i n t e s t i n a l m e t a p l a s i a caused by Helieobacter pyloriinfection i n Mongolian gerbils. (Abstract# G0622) S Honda, T Fujioka, M Tokieda, T Gotoh, A Nishizono and M Nasu. Oita, Japan

DDW Poster of Distinction: Selection of H. pyloriLewis e x p r e s s i o n is d e p e n d e n t o n host Lewis p h e n o t y p e i n r h e s u s m o n k e y s . (Abstract# G1358) HP Wirth, M Yang, A Dubois, DE Berg and MJ Blaser. Ziirich, Switzerland; Nashville, TN; Bethesda, MD and St Louis, MO Long t e r m a n d s e c o n d - g e n e r a t i o n a l effects of mass t r e a t m e n t for e r a d i c a t i o n of H. pylorlin sociallyh o u s e d n o n - h u m a n primates. (Abstract# G0450) A Dubois, A Lilly, K Holmes, GI Perez-Perez and MJ Blaser. Bethesda, MD; Yemassee, SC and Nashville, TN E x p r e s s i o n of m a t r i x m e t a l l o p r o t e i n a s e s i n gastric u l c e r tissue a n d i n t e r a c t i o n b e t w e e n fibroblasts a n d Helicobacter pylori in vitro. (Abstract# G1394) T Yokoyama, Y Otani, N Kurihara, Y Sakurai, K Kameyama, N Igarashi, M Kimata, T Kubota, K Kumai and M Kitajima. Tokyo and Tochigi, Japan The r h e s u s m o n k e y model of Helicobacterpylor~. serodetection a n d selection of specific pathogen-free animals. (Abstract# Gl192) /IV Solnick, DR Canfield, S Yang and J Parsonnet. Davis and Stanford, CA

The Helleobacter pylori vacA g e n o t y p e a n d t h e cage gene are associated with g a s t r o d u o d e n a l disease. (Abstract# G0483) CA Failone, R Beech, A Barkun, M G6ttke, V Loo and T Nguyen. Montreal, Canada

April 1998

PROGRAMOFTHEANNUALMEETINGP29

A G A P O S T E R S E S S I O N m S U N D A Y , M A Y 17, 1998 The e n i g m a of Bnsselton: a h i g h s e r o p r e v a l e n c e of CagA i n families l i v i n g i n a r u r a l c o m m u n i t y of Australia. (Abstract# G0937) H Mitchell, HH-X Xia, DJE Cullen, KJ Christiansen, J Epis, BJ Collins, SL Hazell and NJ Talley. Sydney and Perth, Australia High levels of vacA d i v e r s i t y i n t h e context of infection w i t h m u l t i p l e Helieobacterpylori s t r a i n s i n Mexican p a t i e n t s . (Abstract# G0953) R Morales, G CastiUo, G Gonzalez, A Ballesteros, S Ponce de Leon, A Cravioto, JC Atherton and Y LopezVidal. Mexico City, Mexico and Nottingham, United Kingdom Analysis of vac,4 d i v e r s i t y a m o n g Helicobacterpylori isolates from S o u t h Africa: lack of s t r a i n s w i t h the p a t h o g e n i c vacA s l a g e n o t y p e a n d discovery of a vacA s2/ml allele. (Abstract# G0824) DP Letley, A Lastovica, JA Louw, CJ Hawkey and JC Atherton. Nottingham, United Kingdom and Cape Town, South Africa

D D W Poster of Distinction: Geographic d i s t r i b u t i o n of Helicobacterpylori vacA genetic types. (Abstract# G1310) LJ van Doom, C Figueiredo, F M6graud, MJ Blaser and W Quint. Delft, The Netherlands; Porto, Portugal; Bordeaux, France and Nashville, TN G e n e t i c c h a r a c t e r i s t i c s of H. pylorJisolates from a s y m p t o m a t i c Alaska n a t i v e p o p u l a t i o n . (Abstract# G0546) MF Go, L Cissell, DY Graham and AJ Parkinson. Houston, TX and Anchorage, AK

H. pylord vacA mosaicism: h o m o g e n e i t y i n the signal r e g i o n b u t h e t e r o g e n e i t y i n the mid°gene r e g i o n c o r r e l a t e s w i t h geographic site. (Abstract# G0547) MF Go, L Cissell, JG Kim and O Gutierrez. Houston, TX; Seoul, Korea and Bogota, Colombia

H. pylori show r e m a r k a b l e genetic h e t e r o g e n e i t y b o t h c h r o m o s o m a l l y a n d extra-chromosomally. (Abstract# G0548) MF Go, L Cissell, DY Graham, JG Kim and O Gutierrez. Houston, TX; Seoul, Korea and Bogota, Colombia

Helicobacterpyloriinfection i n p a t i e n t s w i t h a n d w i t h o u t c o r o n a r y h e a r t disease. (Abstract# G0924) H Menge, A Lang, R Hopert, B Brosius, H L611genand U Boenigk. Remscheid, Germany PANCREATIC DISORDERS - - CELL PHYSIOLOGY AND N E U R O H O R M O N A L R E G U L A T I O N

D D W Poster of Distinction: C h a r a c t e r i z a t i o n of a n o v e l secretagogue r e g u l a t e d c a l c i n e u r i n s u b s t r a t e i n exocrine pancreas. (Abstract# G2083) M Yoshida, GE Groblewski, MJ Bragado and JA Williams. Ann Arbor, MI

D D W Poster of Distinction: A novel d y n a m i n - l i k e p r o t e i n associates with t u b u l e s of the e n d o p l a s m i c r e t i c u l u m i n p a n c r e a t i c a c i n a r cells. (Abstract# G2082) Y Yoon, KR Pitts and MA McNiven. Rochester, MN A c t i v a t i o n of p38 MAP kinase/Hsp 27 p a t h w a y b y c h o l e c y s t o k i n i n r e s u l t s i n a c t i n cytoskeletal changes i n r a t p a n c r e a t i c acini. (Abstract# G2015) C Schaefer, GE Groblewski, SA Ernst and JA Williams. Ann Arbor, MI

C h o l e c y s t o k i n i n r e g u l a t e s p h o s p h o r y l a t i o n of i n i t i a t i o n factor eIF4E: a n a d d i t i o n a l m e c h a n i s m for t r a n s l a t i o n a l c o n t r o l of a c i n a r p r o t e i n synthesis. (Abstract# G1805) MJ Bragado and JA Williams. Ann Arbor, MI Adhesion molecule ICAM-1 is p r e s e n t a n d f u n c t i o n s i n r a t p a n c r e a t i c a c i n a r cells. (Abstract# G2088) V Zaninovic, AS Gukovskaya, I Gukovsky, SKim and SJ Pandol. Los Angeles, CA P a n c r e a t i t i s associated p r o t e i n - I gene e x p r e s s i o n is i n d u c e d b y cytosolic c a l c i u m level i n c r e a s e i n r a t p a n c r e a t i c a c i n a r cells: redox- a n d NF-KB-dependence. (Abstract# G1960) D Malka, S Vasseur, E Ortiz, JC Dagorn and JL Iovanna. Marseille, France D y n a m i n p a r t i c i p a t e s i n the f o r m a t i o n of c l a t h r i n - a n d n o n c l a t h r i n - c o a t e d vesicles from the tran~Golgi network. (Abstract# G1923) SM Jones, JR Henley, H Cao, KE Howell and MA McNiven. Denver, CO and Rochester, MN P a n c r e a t i c a c i n a r cells express IL-6, KC, MCP-1, a n d MIP-2: evidence from RT-PCR a n a l y s i s of microscopically isolated a c i n a r cells. (Abstract# G1801) T Blinman, A Gukovskaya, I Gukovsky, V Zaninovic, E Livingston and SJ Pandol. Los Angeles, CA R y a n o d i n e r e c e p t o r is p r e s e n t i n r a t p a n c r e a t i c a c i n a r cells. (Abstract# G1861) TJ Fitzsimmons, JA McRoberts, I Gukovsky, E Rodriguez, FA Lai and SJ Pandol. Los Angeles, CA and London, United Kingdom The Ras-related small G T P - b i n d i n g p r o t e i n Rab4 is involved i n r e g u l a t e d exocytosis of r a t p a n c r e a t i c acini. (Abstract# G1986) H Ohnishi, T Mine, T Tsuchida and T Fujita. Tokyo, Japan Metalloproteinases r e g u l a t e s i g n a l t r a n s d u c t i o n p a t h w a y s t r i g g e r e d b y e x t r a c e l l u l a r m a t r i x proteins. (Abstract# G1889) AS Gukovskaya, I Gukovsky, V Zaninovic, DT Kira and SJ Pandol. Los Angeles, CA H e t e r o g e n e i t y of the h u m a n exocrine p a n c r e a s : antidigestive e n z y m e a n t i b o d y a n d l e c t i n b i n d i n g . (Abstract# G1777) JW Adelson, JA Coutu, A Saluja and M Steer. Providence, RI and Boston, MA R e g u l a t i o n of p a n c r e a t i c m e m b r a n e d i p e p t i d a s e mRNA expression a n d i d e n t i f i c a t i o n as zymogen g r a n u l e m e m b r a n e p r o t e i n b y p e p t i d e sequencing. (Abstract# G1910) T H6fken, D Linder, R Kleene, B G6ke and ACC Wagner. Marburg and GieBen, Germany Fat i n d u c e d changes of the i n t e g r i t y of r a t exocrine p a n c r e a s m e a s u r e d in vivo a n d i n vitro. (Abstract# G1820) P Chowdhury, M Nishikawa, GT Blevins, Jr and PL Rayford. Little Rock, AR B o m b e s i n s t i m u l a t e s b i c a r b o n a t e a n d fluid secretion i n isolated g u i n e a pig p a n c r e a t i c ducts via GRPp r e f e r r i n g b o m b e s i n receptors. (Abstract# G2064) G Varga, K Kordas, DH Coy, TF Lang, MC Steward and RM Case. Budapest, Hungary; New Orleans, LA and Manchester, United Kingdom

P30 PROGRAM OF THE ANNUAL MEETING

II

AGA

POSTER

GASTROENTEROLOGY

SESSION

U n e x p e c t e d l y h i g h m u t a t i o n a l r a t e of K-ras c o d o n 12 i n t h e p a n c r e a t i c j u i c e of p a t i e n t s w i t h p a n c r e a t i c cyst; analysis using preferential homoduplex formation assay. (Abstract# G2052) K Tateishi, M Tada, Y K0matsu, T Oka, S Maekawajiri, K Takemura, R Kawaguchi, H Isayama, M Yamagata, N T0da, N Ohashi, H Yoshida, T Kawabe, Y Shiratori and M Omata. Tokyo, Japan Effects of b i l e a c i d s o n s e c r e t i o n b y d o g p a n c r e a t i c d u c t e p i t h e l i a l cells. (Abstract# G1990) CN Okolo, MW Moody and TD Nguyen. Seattle, WA An e l e c t r o g e n i c a l l y - d r i v e n p a n c r e a t i c Na÷:3HCO3" c o t r a n s p o r t e r d i c t a t e s HCO 3" u p t a k e i n b o t h Capan-1 a n d CFPAC-1 cells. (Abstract# G2032) H Shumakcr, E K0pras, Z Wang, C Ulrich and M S01eimani. Cincinnati, OH cAMP p o t e n t i a t e s HCO3" u p t a k e v i a a n e l e c t r o g e n i c a l l y d r i v e n Na÷:3HCO3" c o t r a n s p o r t e r o n l y in p a n c r e a t i c d u c t e p i t h e l i a l cells e x p r e s s i n g f u n c t i o n a l CFTR. (Abstract# G2033) H Shumaker, E K0pras, H Amlal, C Ulrich and M Soleimani. Cincinnati, OH Effect of f a t t y acid, v i t a m i n E a n d g l u t a t h i o n e on t h e e x p r e s s i o n of a r y l h y d r o c a r b o n r e c e p t o r i n p a n c r e a t i c d u c t a l cell (TAKA-1). (Abstract# G2090) J Zhang, VA Tan, D Heber and VLW Go. Los Angeles, CA

DDW Poster of Distinction: F o c u s e d c r o s s - c h i m e r i c a n a l y s i s of secretin/VIP ligandr e c e p t o r i n t e r a c t i o n s . (Abstract# G1994) CG Park, SC Ganguli, D Pinon and LJ Miller. Rochester, MN A g o n i s t - o c c u p i e d VIP-1 a n d s e c r e t i n r e c e p t o r s h a v e c o n t r a s t i n g effects on G 1 -~ S p h a s e t r a n s i t i o n b u t s i m i l a r l y i n h i b i t G2/M -~ G 1 p r o g r e s s i o n i n t h e s a m e d u c t a l p a n c r e a t i c c a n c e r cells. (Abstract# G1935) E K0pras, J Cornelius, G Babcock and C Ulrich, Cincinnati, OH MEK-1 p l a y s a n i m p o r t a n t r o l e i n E G F i n d u c t i o n a n d c A M P - m e d i a t e d i n h i b i t i o n of E R K p h o s p h o r y l a t i o n a n d G 1 -~ S p h a s e t r a n s i t i o n i n d u c t a l p a n c r e a t i c c a n c e r cells. (Abstract# G2585) E K0pras, J Cornelius, G Babcock and C Ulrich. Cincinnati, OH S t i m u l a t i o n of t r a u s l o c a t i o n a n d t y r o s i n e p h o s p h o r y l a t i o n of p130 cas i n r a t p a n c r e a t i c a c i n a r cells b y c h o l e c y s t o k i n i n . (Abstract# G1858) HA Ferris, JA Tapia, RT Jensen and LJ Garcia. Bethesda, MD and Cficeres, Spain I n t r a c e l l u l a r p a t h w a y for a c t i v a t i o n of SRC k i n a s e c a s c a d e f o l l o w i n g CCK s t i m u l a t i o n i n r a t p a n c r e a t i c acini. (Abstract# G2056) Y Tsunoda, F Nozu, TO Lankisch, H Y0shida and C Owyang. Ann Arbor, MI Novel a p p r o a c h to c h a r a c t e r i z e s i g n a l t r a u s d u c t i o n p a t h w a y s i n p a n c r e a t i c t u m o r cell lines. (Abstract# G1893) R Giinther, I Stolze, M Witt, UR F~lsch and WE Schmidt. Kiel, Germany C o n c e n t r a t i o n - d e p e n d e n t a c t i v a t i o n of d i f f e r e n t signal t r a n s d u c t i o n p a t h w a y s b y PACAP (1-38) i n t h e r a t p a n c r e a t i c t u m o r cell line AR42J. (Abstract# G1892) R Giinther, I Bauer, UR FSlsch and WE Schmidt. Kiel, Germany

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G a s t r i n s t i m u l a t e s t h e f o r m a t i o n of a p60-cSRC/p125FAK c o m p l e x u p s t r e a m of t h e P I 3-kinase s i g n a l i n g p a t h w a y . (Abstract# G1833) L Daulhac, A Kowalski-Chauvel, N Vaysse, L Pradayrol and C Seva. Toulouse, France E x p r e s s i o n a n d p o t e n t i a l f u n c t i o n s of p r o t e i n a s e a c t i v a t e d r e c e p t o r - 2 i n p a n c r e a t i c a c i n a r cells. (Abstract# G1877) RE Glasgow, W Kong, CU Cervera, SJ Mulvihill and NW Bunnett. San Francisco, CA Retinoic acid receptor-a mediates growth inhibition by r e t i n o i d s i n r a t p a n c r e a t i c c a r c i n o m a DSL-6A/C1 cells. (Abstract# G1807) FH Brembeck, A Kaiser, K Detjen, H H0tz, T Foitzik, HJ Buhr, EO Riecken and S Rosewicz. Berlin, Germany M i t o g e n - a c t i v a t e d p r o t e i n k i n a s e s a r e i n v o l v e d in GLP1-mediated s i g n a l t r a n s d u c t i o n . (Abstract# G2042) I Stolze, R Giinther, UR F~lsch and WE Schmidt. Kiel, Germany Nitric o x i d e i n p a n c r e a t i c r e s p o n s e to i n t e s t i n a l a n d s e n s o r y n e u r a l s t i m u l a t i o n . (Abstract# G0302) J Bilski, J Jaworek, A Dembiflski, Z Warzecha, W Biela~ski and SJ Konturek. Cracow, Poland

DDW Poster of Distinction: L i p i d s t i m u l a t e d s e c r e t i o n of CCK is m e d i a t e d b y CCKreleasing peptide (diazepam binding inhibitor): i n v o l v e m e n t of m u c o s a l s e r o t o n i n a n d s u b m u c o s a l s u b s t a n c e P a n d c h o l i n e r g i c n e u r o n s . ( A b s t r a c t # G1900) Y Hao, Y Li and C Owyang. Ann Arbor, MI Role of p a n c r e a t i c o d u o d e n a l n e u r a l c o n n e c t i o n s in c o o r d i n a t i o n of i n t e r d i g e s t i v e u p p e r g u t m o t i l i t y a n d p a n c r e a t i c secretion. (Abstract# G1957) E Luque-de Ledn, M Grewe, J Duenes, EP DiMagno and MG Sarr. Rochester, MN E a r l y a d a p t i v e c h a n g e s i n n e u r o h o r m o n a l c o n t r o l of t h e r a t e x o c r i n e p a n c r e a s w i t h 7 d a y s of c h r o n i c alcohol ingestion. (Abstract# G1837) X Deng, PG Wood, MRA Pedroso, P Eagon and DC Whitcomb. Pittsburgh, PA Secretagogue-specific d e p l e t i o n of z y m o g e n g r a n u l e s from s e l e c t e d p a n c r e a t i c a c i n i a n d c h a n g e s i n g r a n u l e m o r p h o l o g y d u r i n g s t i m u l a t i o n w i t h CCK a n d m e t h a c h o l i n e . (Abstract# G1794) SS Bharwani, JA C0utu and JW Adelson. Providence, RI S o m a t o s t a t i n does n o t i n h i b i t s e c r e t i o n o f l u m i n a l c h o l e c y s t o k i n i n r e l e a s i n g f a c t o r in c o n s c i o u s r a t s . (Abstract# G1971) K Miyasaka, M Masuda, S Kanai, K Tateishi and A Funakoshi. Tokyo and Fukuoka, Japan A d r e n e r g i c m o d u l a t i o n of n e r v e - s t i m u l a t e d a m y l a s e s e c r e t i o n b y i s o l a t e d r a b b i t p a n c r e a t i c lobules. (Abstract# G1955) JA Love and K Szebeni. Jackson, MS H i s t o c h e m i s t r y a n d e l e c t r o p h y s i o l o g y of a d u l t r a b b i t p a n c r e a t i c n e u r o n s in p r i m a r y c u l t u r e . (Abstract# G1956) JA Love and K Szebeni. Jackson, MS Role of M1- a n d c h o l e c y s t o k i n i n A r e c e p t o r s i n t h e e n t e r o p a n c r e a t i c reflexes. (Abstract# G1980) E Niebergall-Roth, S Teyssen and MV Singer. Mannheim, Germany

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S e r o t o n i n a n d e n d o g e n o u s n o r e p i n e p h r i n e i n t e r a c t to c o n t r o l e x o c r i n e p a n c r e a t i c s e c r e t i o n i n the rat. (Abstract# G1976) C Nagian-Domaine, J Chariot and C Roz4. Bichat and Paris, France

B i l i a r y m a n o m e t r y i n AIDS-related cholangitis: r e l a t i o n s h i p to s y m p t o m s a n d radiological findings. (Abstract# G2181) P Neild, D Westaby, H Sansom and B Gazzard. London, United Kingdom

D D W Poster of Distinction:

S u b s t a n c e P is a n e u r o t r a n s m i t t e r t h a t s t i m u l a t e s the p o r c i n e s p h i n c t e r of Oddi. (Abstract# G2219) EA Stoner, AJK Piotrowicz, C Hepworth, DF Evans and CC Ainley. London, United Kingdom

E x p r e s s i o n a n d m o d u l a t i o n of MAP k i n a s e s a n d cell cycle r e g u l a t o r y p r o t e i n s d u r i n g p a n c r e a s r e g e n e r a t i o n . (Abstract# G1830) J Cristebal Aliaga, E Calvo, J Morisset and N Rivard. Sherbrooke, Canada Morphological c h a r a c t e r i z a t i o n of e x t r a c e l l u l a r m a t r i x f o r m a t i o n a n d t i m e d e p e n d e n t r e g u l a t i o n MMPs a n d T I M P S s i n TGF-a t r a n s g e n i c mice. (Abstract# G2068) M Wagner, MG Bachem, H Lfihrs, G Adler and RM Schmid. Ulm, Germany B o m b e s i n s t i m u l a t e s angiogenesis i n large m a m m a l i a n p a n c r e a s a n d MAPK a c t i v i t y a n d p r o l i f e r a t i o n o n e n d o t h e l i a l cells. (Abstract# G1843) E Distrutti, S Fiorucci, M Pensi, A Bufalari, GC Di Renzo, G Coata, B Federici and A MoreUi. Perugia, Italy T r a n s f o r m i n g g r o w t h factor-~ activates mitogena c t i v a t e d k i n a s e s i n p a n c r e a t i c a c i n a r cells. (Abstract# G2036) D Simeone, C Schaefer, B Nicke, T Pham and C Logsdon. Ann Arbor, MI T h i a z o l i d i n e d e r i v a t i v e s p r e v e n t p a n c r e a t i c exocrine and endocrine dysfunction in rat with insulin-resistant d i a b e t e s m e l l i t n s a n d c h r o n i c p a n c r e a t i t i s . (Abstract# G2027) K Shimizu, K Shirateri, M Kobayashi, S Watanabe and N Hayashi. Tokyo, Japan Deletion of interleukin-lbeta c o n v e r t i n g enzyme does n o t p r e v e n t p a n c r e a t i c a c i n a r cell apoptosis i n d u c e d by e i t h e r a p a n c r e a t o t o x i n or b y w i t h d r a w a l of a t r o p h i c s t i m u l u s . (Abstract# G1795) M Bhatia, A Saluja, HS Lee, JL Fr0ssard, L Bhagat and ML Steer. Boston, MA I m m u n o h i s t o c h e m i c a l c h a r a c t e r i z a t i o n of p a n c r e a t i c t u m o r s i n d u c e d b y DMBA i n rats. (Abstract# G1920) RE Jimenez, K Z'graggen, AL Warshaw, F Graeme-Cook, W Hartwig, S Kupa, JA Rivera, DW Rattner and C Fernandez-del Castillo. Boston, MA I n d u c t i o n of apoptosis i n a p a n c r e a t i c cancer cell line b y IKB gene t r a n s f e r . (Abstract# G1924) S Kajino, M Suganuma, Y Marugami, T Funabiki, T Tetsuka, T Kawabe, M Itoh and T Okamoto. Nagoya and Toyoake, Japan BILIARY DISORDERS - - MOTILITY AND PATHOPHYSIOLOGY C a l c i u m sources m e d i a t i n g h u m a n gallbladder smooth m u s c l e c o n t r a c t i o n b y acetylcholine a n d cholecystokinin. (Abstract# G2158) JK Lee, PL Rhee, TM Kang, J Kim, KC Koh, SW Paik, JC Rhee and KW Ch0i. Se0ul, Korea Myosin l i g h t c h a i n p h o s p h o r y l a t i o n a n d force d e v e l o p m e n t i n g a l l b l a d d e r s m o o t h muscle from p r e g n a n t a n d n o n p r e g n a n t g u i n e a pigs. (Abstract# G2199) JP Ryan, R Garbarin0, JS Martin and HP Parkman. Philadelphia, PA

H a l o t h a n e r e d u c e s p o r c i n e s p h i n c t e r of Oddi activity. (Abstract# G2218) EA Stoner, AJK Piotrowicz, DF Evans, CC Hepworth and CC Ainley. London, United Kingdom Effect of L - a r g i n i n e o n g a l l b l a d d e r motility. (Abstract# G2240) AS van Petersen, HAJ Gielkens, J Ringers, CBHW Lamers and AAM Masclee. Leiden, The Netherlands I m m e d i a t e r e d u c t i o n of p a n c r e a t i c SO p r e s s u r e after endoscopic i n j e c t i o n of b o t u l i n u m toxin: i m p l i c a t i o n s for p r e v e n t i o n of E R C P - i n d u c e d p a n c r e a t i t i s . (Abstract# G2185) PI Okol0, Ill, S Hill, K Wadwa, CA Magee, PJ Pasricha and AN Kalloo. Baltimore, MD Effect of d u o d e n a l d i s t e n s i o n o n s p h i n c t e r of Oddi motility. (Abstract# (]12256) BM Yoo, JH Kim, YJ Shin, IR Hwang, KJ Lee, KB Hahm, YS Kim and SW Cho. Suwon, Korea C o m p a r i s o n b e t w e e n physiologic a n d s o m a t o s t a t i n i n d u c e d high f r e q u e n c y c o n t r a c t i o n s i n s p h i n c t e r of Oddi i n h u m a n s . (Abstract# G2255) BM Yoo, JH Kim, JM Kim, KB Hahm and SW Cho. Suwon, Korea C o m p a r i s o n b e t w e e n physiologic a n d octreotidei n d u c e d high f r e q u e n c y c o n t r a c t i o n s i n s p h i n c t e r of Oddi i n h u m a n s . (Abstract# G2254) BM Yoo, JH Kim, JM Kim, YJ Shin, KB Hahm and SW Cho. Suwon, Korea Effects of t r i m e b u t i n e o n the s p h i n c t e r of Oddi m o t i l i t y i n p a t i e n t s with post-cholecystectomy pain. (Abstract# G2097) M Barthet, M Bouvier, P Mambrini, J Salducci, JC Grimaud, S Berdah and X Viviand. Marseille and Fresnes, France T h y r o x i n has a d i r e c t effect on: s p h i n c t e r of Oddi contractility. (Abstract# G2135) J Inkinen, J Sand, P Arvola, I P6rsti and I Nordback. Tampere, Finland Diagnosis of s p h i n c t e r of Oddi d y s f u n c t i o n u s i n g 99mTc-DISIDA b i l i a r y s c a n n i n g w i t h m o r p h i n e a u g m e n t a t i o n . (Abstract# G2234) PD Thomas, J Turner, M Burr and BA Chapman. Christchurch, New Zealand UTP s t i m u l a t e s electrogenic b i c a r b o n a t e secretion across CFTR k n o c k o u t m o u s e gallbladder. (Abstract# G2130) MC Harline, NM Walker, GA Weisman and LL Clarke. C01umbia, MO Cyclin D1, p53 o v e r e x p r e s s i o n a n d K-ras m u t a t i o n are detected i n g a l l b l a d d e r carcinomas. (Abstract# G2137) T Itei, K Takei, Y Shinohara, K Takeda, K Nakamura, T Saito and H Oono. Tokyo, Japan

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Chloride c h a n n e l CLC-3 is expressed b y g a l l b l a d d e r e p i t h e l i u m : a p o t e n t i a l r e g u l a t o r of CT secretion. (Abstract# G2093) ZR Abedin, KE Morgenstern, JJ Roslynl AJ Moser and MZ Abedin. Philadelphia, PA Cholestan-3~,5a,6~-triol s u p p r e s s e s bile a c i d - i n d u c e d m u c i n s e c r e t i o n b y dog g a l l b l a d d e r epithelial cells. (Abstract# G2259) T Yoshida, JH Klinkspoor and SP Lee. Seattle, WA G A S T R O I N T E S T I N A L ONCOLOGY - - MOLECULAR G E N E T I C S OF G A S T R O I N T E S T I N A L CANCER I Telomerase is n o t a m a j o r d e t e r m i n a n t of telomere l e n g t h i n colorectal cancer. (Abstract# G2369) M Chida, Y Kineuchi, S Takagi, N Hiwatashi, F Nagashima and T Toyota. Sendal, Japan Telomerase a c t i v i t y i n i n t e s t i n a l m e t a p l a s i a a n d a d e n o m a of t h e stomach. (Abstract# G2927) YS Yang, DS Lee, BH Byun, JY Choi, IS Chung and DH Park. Se0ul, Korea C i r c u l a t i n g m u t a n t DNA i n p a t i e n t s w i t h u p p e r GI cancer. A simplified e x t r a c t i o n a n d d e t e c t i o n p r o c e d u r e . (Abstract# G2391) R Davis, HE Mulcahy, S Carnaby, EM Alstead and MJG Farthing. London, United Kingdom

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The m o l e c u l a r p a t h o l o g y of colorectal c a n c e r i n p a t i e n t s u n d e r t h e age of 40 y e a r s i n Egypt. (Abstract# G2817) AS Soliman, B Levin, ML Bondy, S Eissa, M Mokhtar, S E1-Badawi, S Bayomi, K Ismail, T Watanabe, P Longi, S Houlihan and SR Hamilton. Houston, TX; Cairo and Tanta, Egypt; Baltimore, MD I n h i b i t i o n of Oe-alkylguanine-DNA a l k y l t r a n s f e r a s e augments tumor incidence by K-ras-dependent and i n d e p e n d e n t p a t h w a y s . (Abstract# G2887) R Wali, S Skarosi, F v0n Lintig, J Hart, G Boss, E Dolan, M Bissonnette and T Brasitus. Chicago, IL and San Diego, CA

DDW Poster of Distinction: I n d u c t i o n of cyclin D1 a n d Bclx L i n H-Ras m e d i a t e d t r a n s f o r m a t i o n of r a t i n t e s t i n a l e p i t h e l i a l cells b u t n o t r a t fibroblasts. (Abstract# G2797) J Shao, H Sheng, RN DuBois and RD Beauchamp. Nashville, TN APC a n d K-ras m u t a t i o n s i n colorectal t u m o r i g e n e s i s . (Abstract# G2873) N Umetani, T Masaki, S Sasaki, K Matsuda and T Muto. Tokyo, Japan

Detailed g e n o m e a n a t o m y of the c o m m m o n l y s t u d i e d gastric a d e n o c a r c i n o m a cell lines. (Abstract# G2934) Y-L Zheng, A Herr and LJ Ferrin. Bethesda, MD

Absence of somatic a l t e r a t i o n s of t h e EB1 gene APCassociated p r o t e i n i n h u m a n s p o r a d i c colorectal cancer. (Abstract# G2531) P Jais, JC Sabourin, J Bombled, P Rougier, P Lasser, P Duvillard, J B~nard and B Bressac-de Paillerets. Villejuif and Paris, France

DNA f i n g e r p r i n t i n g strategies to i d e n t i f y n o v e l genetic events i n p a n c r e a t i c cancer. (Abstract# G2812) V Sirivatanauksorn, AB McKie, Y Sirivatanauksorn and NR Lemoine. London, United Kingdom

Folate deficiency i n d u c e s DNA s t r a n d b r e a k s w i t h i n the APC gene of the r a t colon. (Abstract# G2375) SW Choi, YI Kim, HW Baik and JB Mason. Boston, MA and Toronto, Canada

C o m p a r a t i v e g e n o m i c h y b r i d i z a t i o n reveals nonr a n d o m c h r o m o s o m a l a b e r r a t i o n s to be associated with p r o g r e s s i o n f r o m colorectal a d e n o m a to c a r c i n o m a . (Abstract# G2646) GA Meijer, MAJA Hermsen, PJ van Diest, SGM Meawissen, JMN H00vers, H Joenje, PJF Snijders, JMM Walboomers and JPA Baak. Amsterdam, The Netherlands

DDW Poster of Distinction:

Detection of genetic i m b a l a n c e s i n h u m a n n e u r o e n d o c r i n e t u m o r s of t h e gut a n d the p a n c r e a s . (Abstract# G2451) S Franke, G Thiel, HD F0ss, H Stein, H Buhr, P Neuhaus, E-O Riecken and H Scherfibl. Berlin, Germany I d e n t i f i c a t i o n b y d i f f e r e n t i a l d i s p l a y of m e t a l l o t h i o n e i n - I I , a gene differentially expressed i n gastric cancer. (Abstract# G2414) M Ebert, J Hoffmann, HU Schulz, H Lippert, A Roessner and P Malfertheiner. Magdeburg, Germany D o w n r e g u l a t i o n of a h o m o c y s t e i n e - i n d u c e d novel gene i n m e t a s t a t i c h u m a n colon cancer. (Abstract# G2482) RJ Guan, JB Zhang, K Martin, H Ford, Y Fu and AB Pardee. Boston, MA Microsatellite a n a l y s i s a n d DNA ploidy p a t t e r n i n s i g n e t - r i n g cell c a r c i n o m a s a n d well d i f f e r e n t i a t e d a d e n o c a r c i n o m a s of the stomach. (Abstract# G2573) T Kimura, R Manabe, T Iwase, H Sate, H Konishi, T Kodama, K Kashima and T Hattori. Kyoto and Shiga, Japan F r e q u e n t allelic i m b a l a n c e at c h r o m o s o m e 13q i n gastric c a n c e r i n Korea. (Abstract# G1378) Y Yamaoka, DY Graham, AR Sepulveda and JG Kim. Houston, TX and Seoul, Korea

G u a n y l i n is d o w n r e g u l a t e d i n h u m a n a n d m o u s e i n t e s t i n a l a d e n o m a s . (Abstract# G2825) KA Steinbrecher, T Tuohy, K Goss, C Scott, D Witte, J Groden and MB Cohen. Cincinnati, OH P l a k o g l o b i n (7-catenin) m u t a t i o n s i n gastric cancer. (Abstract# G2345) K Caca, F K011igs,G Hu, M Hayes and ER Fear0n. Ann Arbor, MI Nucleocytoplasmic s h u t t l i n g of t h e hdm2 o n c o p r o t e i n regulates t h e levels of p53 p r o t e i n via a p a t h w a y used b y the h u m a n i m m u n o d e f i c i e n c y v i r u s REV p r o t e i n . (Abstract# G2762) J R0th, M D0bbelstein, D Freedman, T Shenk and A Levine. Princeton, NJ Cytoplasmic a c c u m u l a t i o n of p53 occurs i n i n t e s t i n a l m e t a p l a s i a associated with gastric ulcers b u t n o t with d u o d e n a l ulcers. (Abstract# G2405) A Driessen, N Ectors, I Chen, M Peeters, E Van Cutsem, L Filez, F Penninckx, P Rutgeerts and K Geboes. Leuven, Belgium Correlations b e t w e e n p53 overexpression, s e r u m a n t i b o d i e s a n d gene m u t a t i o n i n colorectal cancer. (Abstract# G2489) P Hammel, K Leroy-Viard, MT Chaumette, J Villaudy, MC Falzone, D Rouillard, Y Remvikos and T Soussi. Clichy, Cr6teil and Paris, France

April1998 II

PROGRAM OF THE ANNUAL MEETING

P33

A G A P O S T E R S E S S I O N - - SUNDAY, M A Y 17, 1998

Exon-specific p53 gene DNA s t r a n d b r e a k s are p r e s e n t i n n o r m a l colonic m u c o s a from i n d i v i d u a l s h a r b o r i n g colonic a d e n o m a s . (Abstract# G2298) HW Balk, SW Choi, T Levesque, D Karp, T Banerjee, JB Mason and the Folate and Polyp Study Group. Boston and Brookline, MA; Marshfield, WI p53 p r o t e i n a c c u m u l a t i o n a n d colonic a d e n o m a s r e c u r r e n c e . (Abstract# G2726) GA Paspatis, A Zizi, M Tz0uvala, K TriantafyUou, G Chlouverakis, I Elemenogl0u and DG Karaman01is. Crete and Piraeus, Greece A l t e r a t i o n s of t h e DPC4 gene i n h u m a n stomach cancers. (Abstract# G2565) JW Kim, JH Joe, C Moon, HJ Kim, JH Do, JS Chang and SK Chang. Seoul, Korea G A S T R O I N T E S T I N A L ONCOLOGY - - GROWTH FACTORS, SIGNAL T R A N S D U C T I O N AND T R A N S C R I P T I O N FACTORS T r a n s c r i p t i o n a l u p r e g u l a t i o n of t r a n s f o r m i n g g r o w t h factor-~ r e c e p t o r s b y TGF-~I correlates with expression of cyclin D - d e p e n d e n t k i n a s e i n h l b i t o r s . (Abstract# G2575) J Kleeff and M Korc. Irvine, CA TGF-~I i n d u c e s MUC2 m u c i n gene expression i n the TGF-~I RII m u t a t e d LS174t colon c a n c e r cell line. (Abstract# G2365) DP Chauhan, QH Yang, JM Carethers, CL Chang and CR B01and. La Jolla and San Diego, CA I n c r e a s e d e x p r e s s i o n of k e r a t i n o c y t e growth factor i n h u m a n colorectal cancer. (Abstract# G2822) A Stallmach, S Weg-Romers, R Goebel, M Menges, G Sch(ider, G Feifel and M Zeitz. Homburg, Germany TGF-a o v e r e x p r e s s i o n r e s u l t s i n i n v/vo p r o g r e s s i o n of a w e a k l y t u m o r i g e n i c colon c a n c e r cells. (Abstract# G2450) JM Foster, J Willis, M Brattein and JKV Wills0n. Cleveland, OH S - a d e n o s y l m e t h i o n i n e decarboxylase activity is e n h a n c e d i n colon c a n c e r cells s t i m u l a t e d to grow b y e p i d e r m a l g r o w t h factor. (Abstract# G2868) L Turhanowa, V Milovic, R Bauske, WF Caspary and J Stein. Frankfurt, Germany Effects of l o n g t e r m i n f u s i o n of IGF-I o n colonic cell p r o l i f e r a t i o n i n r a t s w i t h c h r o n i c colitis. (Abstract# G2918) CJ Xian, GS Howarth, CE MardeU and LC Read. Adelaide, Australia IGF-I: a p o t e n t s t i m u l a t o r of h u m a n c a r c i n o i d cell p r o l i f e r a t i o n . (Abstract# G2823) M Stamm, B Pircher, D Kim, B G6ke, R Arnold and HC Fehmann. Marburg, Germany mRNA e x p r e s s i o n of L-type c a l c i u m c h a n n e l s increases i n colon cancer. (Abstract# G2683) Y Nagaba, L Zhang, B Vogelstoin, H Cross and S Guggino. Baltimore, MD and Vienna, Austria U n c o u p l i n g of t h e e x p r e s s i o n a n d f u n c t i o n of CCKB / g a s t r i n r e c e p t o r s o n h u m a n colon c a n c e r cell lines. (Abstract# G2459) H Frucht, SA Wank, N Tarasova and Y Xiao. Philadelphia, PA; Bethesda and Frederick, MD

II

F u n c t i o n a l e x p r e s s i o n of m3 m u s c a r i n i c cholinergic receptors o n h u m a n colon c a n c e r cell lines. (Abstract# G2458) H Frucht, RT Jensen, D Dexter and Y Xiao. Philadelphia, PA and Bethesda, MD Gastrin-17 a n d G17-gly i n d u c e p r o l i f e r a t i o n t h r o u g h a c t i v a t i o n of CCK-B/gastrin r e c e p t o r i n LoVo cells. (Abstract# G2287) P Artru, S Attoub, S Levasseur, J-P Laigneau, L Moizo, H Goiot, MJM Lewin and A Bado. Paris, France Evidence for t h e p r e s e n c e of 5-HT8 r e c e p t o r o n t h e h u m a n a d e n o c a r c i n o m a t u m o r cell l i n e COLO 320 DM a n d f u n c t i o n a l c o n s e q u e n c e s of its activation. (Abstract# G2791) H Schw6rer, D Raddatz and G Ramad0ri. G0ettingen, Germany The h u m a n k e r a t i n 4 p r o m o t e r is r e g u l a t e d b y esophageal-specific a n d u b i q u i t o u s t r a n s c r i p t i o n a l activators. (Abstract# G2713) OG Opitz, TD Jenkins, T Inomoto and AK Rustgi. Boston, MA

DDW Poster of Distinction: Travas-activation of the esophageal s q u a m o u s e p i t h e l i a l specific h u m a n k e r a t i n 4 a n d E p s t e i n - B a r r v i r u s ED-L2 p r o m o t e r s b y g u t - e n r i c h e d Kriippel-like factor. (Abstract# G2535) TD Jenkins, OG Opitz, J Okano and AK Rustgi. Boston, MA C o r r e l a t i o n of S p l a n d ZBP-89 p r o t e i n expression w i t h gastric c a n c e r subtype. (Abstract# G2285) K Arii and JL Merchant. Ann Arbor, MI R e g u l a t i o n of epithelial cell g r o w t h b y the p a n c r e a s . e n r i c h e d zinc f i n g e r t r a n s c r i p t i o n factor, PKLF. (Abstract# G2382) T Cook, A Tuma and R Urrutia, Rochester, MN C h a r a c t e r i z a t i o n of a h i g h l y r e l a t e d family of S P l - l i k e t r a n s c r i p t i o n a l r e p r e s s o r p r o t e i n s from p a n c r e a t i c epithelial cell p o p u l a t i o n s . (Abstract#: G2381) T Cook, I Tachibana, K Mesa, M Imoto, B Gebelein, A Tuma and R Urrutia. Rochester, MN GASTROINTESTINAL ONCOLOGY - - CLINICAL AND EPIDEMIOLOGICAL S T U D I E S

DDW Poster of Distinction: Micron scale i m a g i n g of the g a s t r o i n t e s t i n a l t r a c t w i t h optical coherence t o m o g r a p h y . (Abstract# G2334) ME Brezinski, C Pitris, SA Boppart and JG Fujimot0. Boston and Cambridge, MA

DDW Poster of Distinction: Colorectal n e o p l a s m i n p a t i e n t s w i t h acromegaly. (Abstract# G2634) Y Matano, H Iwane, N Hamano, T Okada, Y Takeda, A Nakagawa and H Mabuchi. Ishikawa, Japan576

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GASTROENTEROLOGY Vol. 114 r No. 4

Colorectal cancer, diet a n d p53. (Abstract# G2705) A Obrador, V M0reno, D Bautista, E Cabeza, R Canet, E Benito, X Bosch and J Costa. Palma, Majorca and Barcelona, Spain; New Haven, CT

Complications of r a d i a t i o n after coloanal anastomosis. (Abstract# G2636) C Mathias, JH Pemberton, BG Wolff, S Mathison, D Ilstrup and D Larson. Rochester, MN

S m o k i n g a n d r i s k of colorectal polyps. (Abstract# G2267) C Adams, NR Cruickshank, S Sanders and DG Morton. Birmingham, United Kingdom

Late f u n c t i o n a l o u t c o m e following pre- or p o s t o p e r a t i v e r a d i o t h e r a p y after r e c t a l excision for cancer a n d r e c o n s t r u c t i o n w i t h colonic J - p o u c h - a n a l anastamosis. (Abstract# G2392) N Dehni, RD Schlegel, JE Nic01uzzi, M Guiguet, E Tiret and R Pare. Paris, France

R e g u l a r a s p i r i n u s e is associated w i t h a protective effect for colorectal cancer. (Abstract# G2431) RC Evans, D Ashby, A Hackett, E Williams and JM Rhodes. Liverp0ol, United Kingdom High e n e r g y i n t a k e a n d low p h y s i c a l activity are i n d e p e n d e n t r i s k factors for colorectal cancer. (Abstract# G2429) RC Evans, D Ashby, A Hackett, E Williams and JM Rhodes. Liverpool, United Kingdom

DDW Poster of Distinction: V a r i a t i o n i n use of follow-up t e s t i n g after s u r g e r y for n o n m e t a s t a t i c colorectal cancer. (Abstract# G2383) GS Cooper, Z Yuan, A Chak and AA Rimm. Cleveland, OH Colorectal c a n c e r i n a m u l t i e t h n i c i n n e r city u r b a n group: its a n a t o m i c a l a n d age profile. (Abstract# G2364) D Chattar-C0ra, GD Onime and G Altman. Morristown, NJ R e l a t i o n b e t w e e n t h e age a n d the site d i s t r i b u t i o n of colorectal cancer. (Abstract# G27U) M Okamoto, Y Yamaji, J Kato, T Ikenoue, M Takahashi, H Yoshida, T Kawabe, Y Shiratori and M Omata. Tokyo, Japan Clinical features of large sessile colorectal polyps w i t h a n o d u l e - a g g r e g a t e d a p p e a r a n c e . (Abstract# G2710) M Okamot0, Y Yamaji, J Kat0, T Ikenoue, M Takahashi, H Yoshida, T Kawabe, Y Shiratori and M Omata. Tokyo, Japan The c h a n g i n g i n c i d e n c e of a d e n o c a r c i n o m a of the esophagogastric j u n c t i o n i n n o r t h e r n E n g l a n d . (Abstract# G2901) J Wayman, D Forman, D Craig, SA Raimes and SM Griffin. Newcastle upon Tyne and Leeds, United Kingdom Taxol-coated s t e n t s i n esophageal a d e n o c a r c i n o m a . (Abstract# G0110) DK Manifold, ND Maynard, M Cowling, L Machan, RC Mason and A Adam. London, United Kingdom Risk of gastric c a n c e r is n o t i n c r e a s e d after p a r t i a l gastrectomy. (Abstract# G2305) R Bassily, RA Smallwood and B Crotty. West Heidelberg, Australia P r i m a r y gastric a d u l t T cell l e u k e m i a / l y m p h o m a . (Abstract# G2769) H Sakata, R Iwakiri, M Mizuguchi, A Kuwahara, T Yoshida, T Ohyama, T Koyama and K Fujimoto. Saga, Japan Is h i g h age a "relative" c o n t r a i n d i c a t i o n to p e r f o r m a p a n c r e a t o d u o d e n e c t o m y ? (Abstract# G2874) MI van Berge Heneg0uwen, TM van Gulik, H Obert0p and DJ Gouma. Amsterdam, The Netherlands U t i l i t y of e n d o r e c t a l u l t r a s o u n d i n t h e m a n a g e m e n t of rectal cancer. (Abstract# G2434) DO Faigel and PY Lee. Portland, OR Are f u n c t i o n a l r e s u l t s b e t t e r w i t h a p o u c h coloanal anastomosis? (Abstract# G2635) C Mathias, JH Pembert0n, BG Wolff, S Mathison, D Ilstrup and D Lars0n. Rochester, MN

GASTROINTESTINAL ONCOLOGY - - DIAGNOSIS: SERUM AND T I S S U E MARKERS

DDW Poster of Distinction: Colonization of colonic m u c o s a w i t h i n t r a c e l l n i a r E. coli correlates s t r o n g l y w i t h colorectal cancer. (Abstract# G2832) A Swidsinski, M Khilkin, M Ortner, S Schreiber, J Weber, J Wirth, H Ernst and H Lochs. Berlin, Germany C h a r a c t e r i z a t i o n of a b e r r a n t c r y p t loci i n h u m a n colectomy specimens. (Abstract# G2895) L Wang, LJ Burgart and DA Ahlquist. Rochester, MN Hyperplastic/dysplastic p a t h w a y s i n a b e r r a n t crypt foci from h u m a n colon, (Abstract# G2691) R Nascimbeni, V Vfllanacci, F Donato and B Salerni. Brescia, Italy R e s t r i c t e d epitope of c a r c i n o e m b r y o n i c a n t i g e n m a y be a good m a r k e r for d e t e c t i n g p r e c a n c e r o u s lesions a n d early stage of colonic a n d gastric c a r c i n o m a s . (Abstract# G2802) Z-R Shi, C-Z Yu, F Chen and SH Itzkowitz. San Francisco, CA and New York, NY Study o n the i m m u n o h i s t o c h e m i c a l e x p r e s s i o n of • p l a c e n t a l form giutathione-S-transferase, p53 a n d CEA i n colorectal a d e n o m a s a n d a d e n o c a r c i n o m a s . (Abstract# G2760) MH Roh, SY Han, SR Ch0i, WW Shin and JS Kim. Pusan, Korea O n g o i n g s t u d y o n m d r l a n d m r p i n colorectal carcinoma. (Abstract# G2782) C Schneider, SB Hosch, G Fr6schle, JH Br~sen, JR Izbicki and A Reyman. Hamburg, Germany Detection of c i r c u l a t i n g m i c r o m e t a s t a s e s from g a s t r o i n t e s t i n a l t u m o r s u s i n g RT-PCR: m a y b e n o t so p r o m i s i n g . (Abstract# G2426) R Eskinazi, L Debaisieux, P Robberecht and JL Van Laethem. Brussels, Belgium

DDW Poster of Distinction: I n d u c i b l e n i t r i c oxide s y n t h a s e a n d n i t r o t y r o s i n e i n gastric mucosa of gastric c a n c e r p a t i e n t s . (Abstract# G2473) T Goto, K Haruma, M Yosihara, Y Kitadai, M Ito, M Mihara, T Kamada, S Tanaka, K Sumii and G Kajiyama. Hiroshima, Japan

DDW Poster of Distinction: The v a l u e of GP-87 a n d c a r c i n o e m b r y o n i c a n t i g e n d e t e r m i n a t i o n i n the p a t i e n t w i t h g a s t r i c c a n c e r a n d gastric p r e c a n c e r o u s lesions. (Abstract# G2744) S-X Qiao, M Yuan, X-P Zhang, Z-R Shi and M Tobi. Beijing, PR China; San Francisco, CA and Detroit, MI

P R O G R A M OF T H E ANNUAL M E E T I N G P35

April 1998

II

A G A P O S T E R S E S S I O N m S U N D A Y , M A Y 17, 1998

I n c r e a s e d TNF-a2 m i c r o s a t e l l i t e allele f r e q u e n c y i n p r o x i m a l g a s t r i c a d e n o c a r c i n o m a . (Abstract# G2542) H Kasem, G Gallagher, H-H Oh and RC Stuart. Glasgow, Scotland

GASTROINTESTINAL ONCOLOGY - - DIAGNOSIS AND S T A G I N G

I n t e s t i n a l m e t a p l a s i a i n t h e s t o m a c h is associated with c a n c e r b u t is n o t a n i n d i c a t i o n for s u r v e i l l a n c e endoscopy. (Abstract# G2543) H Kasem, JJ Going, C MacKay, H Ihmaidat, A Foulis, R Carter and RC Stuart. Glasgow, Scotland

Non-biopsy t e c h n i q u e s for q u a l i t a t i v e diagnosis of colorectal t u m o r . (Abstract# G2546) S Kato, T Fujii, I Koba, M Ohkuwa, T Miyazaki, T Kurahashi, RB Elisa, K H0sokawa, A Ohtsu, SH Park, H Park, S Tajiri and S Yoshida. Chiba, Japan

A u t o m a t i o n of g a s t r i c b r u s h s m e a r q u a n t i t a t i v e D N A analysis. (Abstract# G2659) B Molnfir, E Szaleczky, L Pr6nai, K Papik, T Z~igoniand Z Tulassay. Budapest, Hungary

P i t p a t t e r n diagnosis of d e p r e s s e d t u m o r s of the colon. (Abstract# G2500) S Hayashi, Y Suzuki, M Kobayasi, T Honma, R Narisawa and H Asakura. Niigata, Japan

E v a l u a t i o n of gastric c a n c e r s c r e e n i n g u s i n g a s e r u m p e p s i n o g e n level or a n anti-Helleobacterpylorl a n t i b o d y , c o m p a r e d w i t h endoscopic f i n d i n g s as c r i t e r i o n s t a n d a r d . (Abstract# G2525) H Ikuma, T Mitsushima and K Nagatani. Chiba, Japan

Superficial depressed colorectal a d e n o c a r c i n o m a s a n d adenomas. Clinicopathological study. (Abstract# G2499) M Hayakawa, K Kusugami, Y Nishi0, M Sugihara, Y M0rooka, T Fujita and M Nakamura. Nagoya, Japan

Soluble CD44v6 a n d CA242 i n p r e o p e r a t i v e sera from p a t i e n t s w i t h gastric a n d esophagus carcinomas. (Abstract# G2592) H-M Kuhn, HT Flammann, D Keeser, R Arndt, E St0ckfleth, G Weinland, C Fibbe, H Frenzel and P Layer. Hamburg and Kiel, Germany E v a l u a t i o n of l e c t i n - r e a c t i v e a l p h a - f e t o p r o t e i n i n patients with hepatocellular carcinoma and chronic liver diseases. (Abstract# G2554) V Van Khien, H Van Mao, T Thi Chinh, P Thu Ha, B Van Lac, N Anh Tuan, L Van Don and M Hong Bang. Hanoi, Vietnam A d i a g n o s t i c m a r k e r for cystic lesions of the pancreas. (Abstract# G2452) SD Freedman, KR Bhaskar, KB Lewandrowski, W Brugge, AL Warshaw, MH Katz, EM Parker and I Waxman. Boston, MA The n e w s t r a t e g y i n the diagnosis of p a n c r e a t i c c a n c e r a n d c h o l a n g i o c a r c i n o m a w i t h CA19-9: n e w cutoff values from ROC (receiver o p e r a t i n g c h a r a c t e r i s t i c curve). (Abstract# G2682) SJ Myung, YS Kim, DW Seo, KN Shim, HJ Kim, SY Won, SH Yang, SK Lee, MH Kim and YI Min. Seoul, Korea T e l o m e r a s e a c t i v i t y i n p u r e p a n c r e a t i c j u i c e for the diagnosis of p a n c r e a t i c c a n c e r m a y be c o m p l e m e n t a r y to K - r ~ m u t a t i o n . (Abstract# G2681) SJ Myung, YS Kim, DW Seo, KN Shim, SH Yang, ER Park, SK Lee, MH Kim and YI Min. Seoul, Korea D e t e c t i o n of K - r a s m u t a t i o n s i n fine needle aspirates of p a n c r e a s c a n n o t d i f f e r e n t i a t e p a n c r e a t i c cancer from c h r o n i c p a n c r e a t i t i s . (Abstract# G2568) Y-T Kim, JK Ryu, JK Han, YB Yoon, IS Song and CY Kim. Seoul, Korea

DDW Poster of Distinction: Differential d i a g n o s i s b e t w e e n p a n c r e a t i c cancer a n d c h r o n i c p a n c r e a t i t i s b y m e a n s of the histochemical oxygen i n s e n s i t i v i t y assay a n d image analysis. (Abstract# G2875) BEM van Driel, TM van Gulik, GJA Offerhaus, DJ G0uma and CJF van Noorden. Amsterdam, The Netherlands

DDW Poster of Distinction:

I n d i a i n k as a colonic t a t t o o i n g agent. (Abstract# G2739) N Price, M Gottfried, E Clary, Dc Lawson, J Baillie, K Mergener, C Westcott, S Eubanks and T Pappas. Durham, NC C o m p a r i s o n of e n d o r e c t a l u l t r a s o u n d a n d CT scan i n the p r e o p e r a t i v e s t a g i n g of colorectal cancer. (Abstract# G2511) M Hiele, AM Gevers, L Mertens, L Van Hoe, E Van Cutsem, L Macken, KP Geboes, N Ectors, L Filez and P Rutgeerts. Leuven, Belgium E n h a n c e d v i r t u a l colonoscopy system e m p l o y i n g a u t o m a t i c detection of colon polyps. (Abstract# G2886) D Vining, Y Ge, D Ahn, D Stelts and B Pineau. WinstonSalem, NC T h r e e - d i m e n t i o n a l CT colography: is it detectable for fiat t u m o r ? (Abstract# G2654) T Miyazaki, T Fujii, S Kate, I K0ba, K Hosokawa, SH Park, A Otsu, H Tajiri, S Yoshida and N Moriyama. Chiba, Japan A d v a n c e d colorectal cancer: e v a l u a t i o n of e x t r a l u m i n a l e x t e n s i o n b y m a g n e t i c r e s o n a n c e i m a g i n g with i n t r a l u m i n a l a d m i n i s t r a t i o n of c o n t r a s t material. (Abstract# G2657) M Mizuguchi, R Matsubayashi, Y Matsuo, K Fujimoto and S Kudo. Saga, Japan Detection of low-grade colonic d y s p l a s i a b y lighti n d u c e d fluorescence endoscopy. (Abstract# G2327) S Brand, T Ochsenk~ihn, H Stepp, R Baumgartner, M Weinzierl, J Holl, C von Ritter, G Paumgartner and M Sackmann. Munich, Germany The basis for the d e c r e a s e d a u t o f l u o r e s c e n c e of a d e n o m a a n d c a n c e r of t h e colon b y l a s e r - i n d u c e d fluorescence endoscopy. (Abstract# G2530) K Izuishi, H Tajiri, T Fujii, S Abe, M Ryu and S Yoshida. Chiba, Japan S c r e e n i n g for colorectal n e o p l a s m s w i t h a n i m m u n o l o g i c a l fecal occult h e m o g l o b i n a n d a l b u m i n test is cost effective. (Abstract# G2807) A Sieg, MR John, K L~ithgens and H Schmidt-Gayk. Heidelberg, Germany M a l i g n a n t esophageal stenoses p r e o p e r a t i v e s t a g i n g b y B o u g i n a g e e n d o s o n o g r a p h y . (Abstract# G2515) N Hoepffner, J P0hle, J Menzel, W Domschke and EC Foerster. Muenster, Germany

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GASTROENTEROLOGYVol. 114rNo. 4 SESSION

V a l i d a t i o n of v o l u m e m e a s u r e m e n t s i n s u b m u c o s a l pseudo t u m o r s u s i n g 3D e n d o l u m i n a l u l t r a s o u n d i n the i n ~ t r o c a n i n e esophagus. (Abstract# G2376) CY Chung, J-B Liu, CA de La Torte, M Sheera and LS Miller. Philadelphia, PA Gastric c a n c e r a n d o t h e r endoscopic f i n d i n i g s i n y o u n g p a t i e n t s w i t h dyspepsia. (Abstract# G2332) NP Breslin, ABR Thomson, RJ Bailey, PK Blustein, J Meddings, I Lalor, GMA VanRosendaal, MJ Verhoef and LR Sutherland. Calgary, Canada P r e v a l e n c e of g a s t r i c c a r c i n o i d a n d e n t e r o c h r o m a f f i n like dysplastic l e s i o n s i n a t r o p h i c b o d y gastritis p a t i e n t s . (Abstract# G2631) M Marignani, MR Aprile, G D'Ambra, C Mancino, P Caruana, R Caprilli, C Bordi, G Delle Fave and B Annibale. Rome and Parma, Italy Three d i m e n s i o n a l a n a l y s i s for gastric c a n c e r u s i n g helical CT s c a n n e r s . (Abstract# G2513) M Hirayama, J Fukaura, Y Hirano, H Matsuya, M Iriyama, E Sasaki, Y Urushizaki, N Ohmi, T Sakawaki, T Kurotaki, S Iyama, H Muramatsu, M Kida and Y Niltsu. Otaru and Sapp0ro, Japan Does c o n t r a s t - e n h a n c e d EUS i m p r o v e the diagnosis over EUS w i t h o u t e n h a n c e m e n t i n u p p e r g a s t r o i n t e s t i n a l t r a c t diseases? (Abstract# G2702) N Nomura, H Goto, Y Niwa, Y Hir0oka, T Arisawa, H Kameyama, M Matsui, S Hayakawa, T Hosoi, M Shinkai and T Hayakawa. Nagoya, Japan Role of e n d o s o n o g r a p h y i n the m a n a g e m e n t of p a t i e n t s with gastric MALT l y m p h o m a . (Abstract# G2821) P Spinelli, M Schiavo, B Borgatta, A Schicchi, G Calarco, C Tondini, R Giardini and G Di Felice. Milan, Italy P r e o p e r a t i v e TN s t a g i n g of gastric MALT-type l y m p h o m a : c o m p a r i s o n of clinical s t a g i n g p r o c e d u r e s w i t h t h e gold s t a n d a r d of p a t h o h i s t o l o g i c a l stage. (Abstract# G2443) W Fischbach, M-E Kolve, A Greiner and H-K MiillerHermelink. Aschaffenburg and Wfirzburg, Germany FDG-PET i n s t a g i n g p r i m a r y g a s t r o i n t e s t i n a l l y m p h o m a . (Abstract# G2317) W Boeck, A Froehlich, A Roempp, SN Roske, MP Lutz and G Adler. Ulm, Germany Gastric c a n c e r s ' a r e a s c a n be d i a g n o s e d by p o r p h y r i n fluorescence w i t h a s i m u l t a n e o u s endoscopic fluorescence a n a l y z i n g system at p h o t o d y n a m i c t h e r a p y . (Abstract# G2680) Y Murata, H Matsui, K Hirano, A Yanaka, A Nakahara and H Mute. Tsukuba, Japan Is a c u t e p a n c r e a t i t i s i n p a n c r e a t i c c a n c e r u n d e r e s t i m a t e d ? (Abstract# G2340) L Buscail, P Pages, O Croizet, N Zalakett, J Frexinos and J Escourrou. Toulouse, France

DDW Poster of Distinction: S t a g i n g of h i l a r bile d u c t c a r c i n o m a s w i t h ERC a n d e n d o l u m i n a l u l t r a s o u n d or m a g n e t i c r e s o n a n c e c h o l a n g i o g r a p h y . (Abstract# G2314) F Bert, F Schmidt, M Wiedmann, JP Schneider and J M6ssner. Leipzig, Germany CT-guided b i o p s y of a b d o m i n a l a n d pelvic lesions i n p a t i e n t s w i t h k n o w n p r i m a r y cancers. (Abstract# G2386) SA Cremer, DJ Ott, MYM Chen, RE Bechteld and DW Gelfand. Winston-Salem, NC

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17, 1998

MOTILITY AND NERVE-GUT I N T E R A C T I O N S - CELL PHYSIOLOGY OF NERVES AND G U T MUSCLE I n t e r s t i t i a l cells a n d t h e i r r e l a t i o n s h i p w i t h n e u r o t r a n s m i t t e r s a n d n e r v e fibers i n t h e h u m a n stomach. (Abstract# G3143) C He, J Gatchel, PF Schmalz, MG Sarr, SM Miller, G Farrugia and JH Szurszewski. Rochester, MN

DDW Poster of Distinction: Effect of PACAP-27 o n the g u i n e a pig i n f e r i o r m e s e n t e r i c g a n g l i o n n e u r o n s . (Abstract# G3094) LG Ermilov and JH Szurszewski. Rochester, MN SNAP-23, SNAP-25 a n d VAMP-2 a r e f o u n d i n feline esophageal s m o o t h muscle. (Abstract# G3231) H Lau, AMP Salapatek, L Sheu, HY Gaisano and NE Diamant. Toronto, Canada H i s t a m i n e blocks A-type p o t a s s i u m c h a n n e l s i n m y e n t e r i c n e u r o n s of g u i n e a p i g small i n t e s t i n e . (Abstract# G3453) AM Star0dub, LV Baidan and JD Wood. Columbus, OH Role of p r e s y n a p t i c N-, P- a n d L-type Ca 2÷ c h a n n e l s i n NO-induced VIP release from i s o l a t e d e n t e r i c n e r v e e n d i n g s of t h e r a t ileum. (Abstract# G3220) M Kurjak, R Fritsch and HD Allescher. Munich, Germany Nitric oxide-mediated slow I J P s i n the c i r c u l a r m u s c l e of the g u i n e a pig i l e u m involve s u p p r e s s i o n of a CaMKII-dependent chloride c o n d u c t a n c e . (Abstract# G3145) XD He, F Vogalis and RK G0yal. West Roxbury and Boston, MA P r e - t e r m i n a l n i c o t i n i c receptors e n h a n c e n o n cholinergic n e u r o m u s c u l a r t r a n s m i s s i o n b u t n o t slow synaptic n e u r o t r a n s m i s s i o n i n g u i n e a pig ileum. (Abstract# G3425) D Schneider and J Galligan. East Lansing, MI Mechanism of 5-HT4 r e c e p t o r - m e d i a t e d f a c i l i t a t i o n of synaptic transmission between myenteric neurons. (Abstract# G3542) X Zhou, E Mess0ri and JJ Galligan. East Lansing, MI A "complete" m a t h e m a t i c a l model of a locus of t h e small bowel. (Abstract# G3306) R Miftakhov and J Christensen. Iowa City, IA Mechanically i n d u c e d c a l c i u m t r a n s i e n t s i n DRG n e u r o n s a r e amiloride sensitive. (Abstract# G3124) JM Gsch0ssmann, J G01iger, HE Rayb0uld, H E n n e s , SH Young and EA Mayer. Los Angeles, CA I n v o l v e m e n t of c a l c i t o n i n g e n e - r e l a t e d p e p t i d e i n the d e v e l o p m e n t of acute visceral h y p e r a l g e s i a i n t h e rat. (Abstract# G3123) JM Gschossmann, JC Miller, V Plourde, HC Wong, JH Walsh and EA Mayer. Los Angeles, CA and Montreal, Canada Amiloride-sensitive s e n s o r y n e u r o n s i n the m y e n t e r i c plexus. (Abstract# G3537) WM Yau and LA Reese. Carbondale, IL

DDW Poster of Distinction: Role of t h e cytoskeleton i n v o l u m e a c t i v a t i o n of a n a n i o n c u r r e n t i n c a n i n e j e j u n a l c i r c u l a r s m o o t h muscle. (Abstract# G3098) G Farrugia. Rochester, MN

April 1998

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DDW Poster of Distinction: The n a t r i u r e t i c p e p t i d e c l e a r a n c e r e c e p t o r is coupled via i n h i b i t o r y G p r o t e i n s to a c t i v a t i o n of PLC-~ a n d i n h i b i t i o n of a d e n y l y l cyclase i n t e n i a coll. (Abstract# G3323) KS Murthy, J-G Jin, B-Q Teng, JR Grider and GM Makhl0uf. Richmond, VA F u n c t i o n a l e x p r e s s i o n of n a t r i u r e t i c p e p t i d e clearance r e c e p t o r i n r a b b i t gastric m u s c l e cells. (Abstract# G3472) B-Q Teng, KS Murthy, J-G Jin and GM Makhl0uf. Richmond, VA

Effects of cyclooxygenase i n h i b i t o r s o n acetylcholines t i m u l a t e d excitation i n c a n i n e p r o x i m a l colon. (Abstract# G3108) H Franck, KM Sanders and CWR Shuttleworth. Reno, NV Inward currents through large conductance channels i n s m o o t h muscle cells of t h e o p o s s u m esophagus. (Abstract# G35U) F V0galis and RK G0yal. West R0xbury and Boston, MA R e d u c e d Ca 2÷ influx c o n t r i b u t e s to d e c r e a s e d c o n t r a c t i l i t y of c i r c u l a r m u s c l e cells i n colonic i n f l a m m a t i o n . (Abstract# G3436) X-Z Shi and SK Sarna. Milwaukee, WI

Effect of exogenous ATP o n c a n i n e j e j u n a l c i r c u l a r s m o o t h m u s c l e cells. (Abstract# G3533) L Xue, G Farrugia and JH Szurszewski. Rochester, MN

Differential d i s t r i b u t i o n of c a l c i u m c h a n n e l s u b u n i t s i n a n t r a l a n d pyloric s m o o t h muscle. (Abstract# G2983) K Bielefeldt. Iowa City, IA

Molecular a n d Ca 2÷ fluorescence s t u d y of t a c h y k i n i n r e s p o n s e s i n h u m a n esophagus: f u n c t i o n a l differences b e t w e e n muscle layers. (Abstract# G3379) HG Preiksaitis, PS Krysiak, LG Laurier, Y Jiao and SM Sims. London, Canada

PACAP a n d VIP r e l a x h u m a n colonic s m o o t h muscle cells b y N O - i n d e p e n d e n t p a t h w a y s . (Abstract# G3192) S Katsoulis, R Neumann, H-J Klomp, A Schmidt, WE Schmidt and UR F6lsch. Kiel, Germany

Cholinergic r e g u l a t i o n of i n w a r d c u r r e n t s i n h u m a n esophageal s m o o t h muscle. (Abstract# G3191) T Karkanis, GR Wade, HG Preiksaitis and SM Sims. London, Canada I n t r a c e l l u l a r Ca 2÷ r e s p o n s e of smooth muscle cells from t h e l o n g i t u d i n a l l a y e r of the r a b b i t distal colon following m e c h a n i c a l a n d chemical s t i m u l a t i o n . (Abstract# G3538) SH Young, HS Ennes and EA Mayer. Los Angeles, CA S o m a t o s t a t i n m e d i a t e s c o n t r a c t i l i t y of t h e h u m a n c i r c u l a r colonic s m o o t h muscle cells t h r o u g h a r e c e p t o r s u b t y p e 2 (sst2). (Abstract# G3043) VD Corlet0, G Roman0, C Severi, G Capurs0, R Str0m, HC Weber, RT Jensen and G Delle Fare. Rome, Italy; Boston, MA and Bethesda, MD Nitric oxide s u p p r e s s e s a c a l c i u m - s t i m u l a t e d chloride c u r e n t i n s m o o t h muscle cells of the opossum esophagus. (Abstract# G3512) F Vogalis, Y Zhang and RK Goyal. West Roxbury and Boston, MA A slowly i n a c t i v a t i n g v o l t a g e - d e p e n d e n t K ÷ c h a n n e l c u r r e n t i n s m o o t h m u s c l e cells of the opossum s p h i n c t e r of Oddi. (Abstract# G3510) F Vogalis. West Roxbury and Boston, MA The role of a r a c h i d o n i c acid release a n d m e t a b o l i s m i n A C h - i n d u c e d c o n t r a c t i o n s i n d i s p e r s e d colonic c i r c u l a r muscle cells. (Abstract# G2943) I All and SK Sarna. Milwaukee, WI Actions of t a c h y k i n i n s a n d n e u r o t e u s i n a n d t a c h y k i n i n like i m m u n o r e a c t i v i t y i n h u m a n colon. (Abstract# G3010) E Butcher, I Markus, F Shang and A Comis. Sydney, Australia Hsp27 m o d u l a t e s s u s t a i n e d c o n t r a c t i o n b y r e v e r s i n g t r o p o m y o s i n i n h i b i t i o n of a c t i n - a c t i v a t e d ATPase activity. (Abstract# G3171) AI Ibitayo, G Groblewski and KN Bitar. Ann Arbor, MI

DDW Poster of Distinction: C o n t r a c t i l e p r o t e i n s t h a t d i s t i n g u i s h phasic from t o n i c s m o o t h muscles. (Abstract# G3468) PT Szymanski, TK Chacko, AS Rovner and RK Goyal. Boston, MA and Burlington, VT

P r o p e r t i e s of A-type p o t a s s i u m c u r r e n t s i n m y e n t e r i c n e u r o n s c u l t u r e d from g u i n e a p i g small i n t e s t i n e . (Abstract# G3454) AM Star0dub, LV Baidan and JD Wood. Columbus, OH Differences b e t w e e n m o t i l i n - a n d m u s c a r i n i c receptorcoupled Ca 2+ s i g n a l l i n g i n a s m o o t h muscle cell line of h u m a n j e j u n u m . (Abstract# G3491) G Van Assche, I Depoortere, L Missiaen, J Janssens and TL Peeters. Leuven, Belgium MOTILITY AND N E R V E - G U T INTERACTIONS - EXTRINSIC AND I N T R I N S I C INNERVATION

DDW Poster of Distinction: Visceral afferent s e n s i t i z a t i o n to b r a d y k i n i n i n r a t j e j u n u m i n vitro, p u t a t i v e role for cyclic AMP. (Abstract# G3008) A Brunsden, K Maubach and D Grundy. Sheffield, United Kingdom

DDW Poster of Distinction: Role for p u r i n e r g i c A 1 r e c e p t o r s i n s u b m u c o s a l secretory reflexes i n t h e g u i n e a pig colon. (Abstract# G3521) Y-Z Wang, FL Christofi, CY Liu, H Zhang and HJ Cooke. Columbus, OH Role for s o m a t o s t a t i n r e c e p t o r s i n d i s c r i m i n a t i n g b e t w e e n m e c h a n o s e n s i t i v e release of 5-HT a n d PGE 2 i n the i n i t i a t i o n of s e c r e t o r y reflexes i n t h e g u i n e a pig colon. (Abstract# G3522) Y-Z Wang, L Alferes, TM O'Dorisio, ', MS O'Dorisio, EA Woltering, DH Coy, WA Murphy, P Ghosh and HJ Cooke. Columbus, OH and New Orleans, LA A r a p i d l y d e s e n s i t i z i n g 5-HT4 r e c e p t o r m e d i a t e s the

p e r i s t a l t i c reflex i n d u c e d b y m u c o s a l stimuli. (Abstract# G3121) JR Grider. Richmond, VA C h a r a c t e r i z a t i o n of t h e r e c e p t o r m e d i a t i n g the excitatory action of a d e n o s i n e o n m e s e n t e r i c afferents i n the a n e s t h e t i z e d rat. (Abstract# G3206) AJ Kirkup, C Eastwood, IP ChesseU, D Grundy and PPA Humphrey. Sheffield and Cambridge, United Kingdom The role of s p i n a l CGRP as a p u t a t i v e n e u r o t r a n s m i t t e r i n visceral h y p e r s e n s i t i v i t y . (Abstract# G3120) B Greenwood-Van Meerveld, KR Tyler, J McDuff and V P10urde. Oklahoma City, OK and Montreal, Canada

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P38 PROGRAM OF THE ANNUAL MEETING

G A S T R O E N T E R O L O G Y V o l . 114 r N o . 4 II

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I n t e r l e u k i n - l ~ sensitizes i n t e s t i n a l afferent n e r v e fibers to o t h e r i n f l a m m a t o r y m e d i a t o r s i n t h e a n e s t h e t i z e d rat. (Abstract# G3142) W Haupt, ME Kreis, HD Becket and D Grundy. Tiibingen, Germany and Sheffield, United Kingdom Cholinergic c o n t r o l of colonic tone. (Abstract# G3475) MS Thollander, S Leelakus01vong, T Chiba, MG Sarr and SF Phillips. Rochester, MN S P i m m u n o r e a c t i v e n e r v e fibers a n d c-kit-positive i n t e r s t i t i a l cells i n t e r r e l a t i o n s h i p s i n the h u m a n distal colon. (Abstract# G3378) C Porcher, M Henry, MO Christen and Y JulY. Marseille and Suresnes, France

D i s t r i b u t i o n of e n z y m e s for r e s y n t h e s i s of L - a r g i n i n e from L - c i t r u l l i n e i n c a n i n e g a s t r o i n t e s t i n a l tract: r e l a t i o n s h i p to NOS. (Abstract# G3055) EE Daniel, Y-F Wang, AM Salapatek and Y-K Mao. Hamilton, Canada and Kumam0t0, Japan

DDW Poster of Distinction:

Localization of Ca 2÷ c h a n n e l s u b t y p e s i n the e n t e r i c n e r v o u s system a n d p a n c r e a s . (Abstract# G3265) M-T Liu and A Kirchgessner. New York, NY M i c r o t u b u l e associated protein-2 occurs i n specific e n t e r i c n e u r o n s of the g u i n e a p i g ileum. (Abstract# G3195) CM Keenan, JB Furness and KA Sharkey. Calgary, Canada and Melbourne, Autralia E x p r e s s i o n of Fos i n the m y e n t e r i c plexus a n d b r a i n s t e m following acute colonic i n f l a m m a t i o n i n t h e rat. (Abstract# G3302) M Miampamba and KA Sharkey. Calgary, Canada Morphology a n d p r o j e c t i o n of t h e type I n e u r o n i n t h e h u m a n small i n t e s t i n e . (Abstract# G3217) H-J Krammer, W Stach, A Brehmer, T Wedel and MV Singer. Heidelberg, Germany MOTILITY AND NERVE-GUT I N T E R A C T I O N S - OROPHARYNGEAL MOTILITY

I d e n t i f i c a t i o n of the c e r e b r a l loci p r o c e s s i n g h u m a n s w a l l o w i n g f u n c t i o n : a H20 x5 P E T a c t i v a t i o n study. (Abstract# G3134) S Hamdy, JC Rothwell, DJ Brooks, Q Aziz and DG Thompson. London and Manchester, United Kingdom

A novel r e h a b i l i t a t i v e exercise for dysphagic p a t i e n t s : effect o n swallow f u n c t i o n a n d b i o m e c h a n i c s . (Abstract# G3082) C Easterling, M Kern, T Nitschke, B Grande, GM Cullen and R Shaker. Milwaukee, WI

R e f e r r e d p a i n i n d u c e d b y i n j e c t i o n of c a p s a i c i n i n t o the r a t gastric artery. (Abstract# G3216) EM Kostarczyk, KA Sluka and GF Gebhart. Iowa City, IA

D e t e r m i n a n t s of swallow r e c o v e r y after stroke: motor, sensory, or both? (Abstract# G3255) S Lin, PJ Kahrilas and JA Logemann. Chicago, IL

Differential effects of n a p r o x e n o n i s c h e m i a a n d r e p e r f u s i o n - i n d u c e d e x c i t a t i o n of j e j u n a l afferents i n t h e a n e s t h e t i z e d rat. (Abstract# G3183) W Jiang and D Grundy. Sheffield, United Kingdom

V a r i a t i o n of l i n g u a l shape a n d d e f o r m a t i o n d u r i n g deglutitive a c c o m m o d a t i o n as a f u n c t i o n of b o l u s rheology. (Abstract# G3U8) RJ Gilbert, VJ Napadow, Q Chen and TW Schenz. Boston, MA and Columbus, OH

Novel aspects o n h i s t a m i n e s e n s i t i v i t y of i n t e s t i n a l afferent n e r v e fibers i n r a t j e j u n u m . (Abstract# G3218) ME Kreis, W Haupt, AJ Kirkup, HD Becker and D Grundy. Tfibingen, Germany and Sheffield, United Kingdom

Electrophysiologic v a l i d a t i o n of d e g l u t i t i v e UES o p e n i n g h e a d lift exercise. (Abstract# G2942) M Alfonso, M Ferdjallah, R Shaker and JJ Wertsch, Milwaukee, WI

The r e l a t i o n s h i p b e t w e e n esophageal acid exposure a n d s e c o n d a r y allodynia: c e n t r a l s e n s i t i z a t i o n c o n t r i b u t e s to visceral h y p e r s e n s i t i v i t y i n man. (Abstract# G34U) S Sarkar, Q Aziz, CJ W0olf, A Hobs0n and DG Thompson. Salford, United Kingdom and Boston, MA

Regional l i n g u a l m e c h a n i c s d u r i n g swallowing: a synergistic model i n v o l v i n g i n t r i n s i c a n d e x t r i n s i c muscle activity. (Abstract# G3328) VJ Napadow, Q Chen, VJ Wedeen and RJ Gilbert. Boston, MA

Cortical r e p r e s e n t a t i o n of t h e a n a l canal. (Abstract# G3460) K Stettrop, A Schnitzler, OW Witte, H-J Freund and P Enck. Dfisseldorf, Germany

C o m p e n s a t o r y a u g m e n t a t i o n of deglutitive b i o m e c h a n i c s i n a s y m p t o m a t i c subjects w i t h cervical osteophytes. (Abstract# G3198) M Kern, R Arndorfer, C Hofmann, E Stewart and R Shaker. Milwaukee, WI

C e r e b r a l a c t i v a t i o n after c h e m i c a l a n d m e c h a n i c a l s t i m u l a t i o n of the h u m a n esophagus. (Abstract# G3397) S Roscher, B Renner, R Kuhlbusch, T Frieling, G Kobal and P Enck. Erlangen-Niirnberg and D(isseldorf, Germany Cardiovagal reflexes a n d p e r c e p t i o n of gastric d i s t e n t i o n following n e o n a t a l c a p s a i c i n i n rats. (Abstract# G3518) L Wang and G T0ugas. Hamilton, Canada

Effect of cigarette s m o k i n g o n p h a r y n g o g l o t t a l a n d esophagoglottal closure reflexes. (Abstract# G3079) K Dua, J Ren, E Bardan, Z Sui and R Shaker. Milwaukee, WI MOTILITY AND NERVE-GUT I N T E R A C T I O N S - ESOPHAGEAL MOTILITY: BASIC SCIENCE

Studies of t h e b r a i n p r o c e s s i n g of h u m a n esophageal sensation using functional magnetic resonance imaging. (Abstract# G2957) Q Aziz, S Williams, S Sarkar, S Hamdy, A Hobs0n and DG Thompson. Salf0rd and London, United Kingdom

DDW Poster of Distinction:

Effect of TNBS o n m e c h a n o s e n s i t i v e pelvic n e r v e afferent fibers w h e n i n s t i l l e d i n t o t h e p r o x i m a l or d i s t a l r a t colon. (Abstract# G3187) V Julia, X Su and GF Gebhart. Iowa City, IA

Biphasic n e r v e - m e d i a t e d r e l a x a t i o n s of t h e o p o s s u m lower esophageal sphincter. Are t h e y m e d i a t e d b y cGMP? (Abstract# G3432) W Shahin, JA Murray, E Clark and JL Conklin. I0wa City, IA

Does cGMP m e d i a t e the off r e s p o n s e of c i r c u l a r smooth muscle from the esophagus of the opossum? (Abstract# G3433) W Shahin, J Murray, E Clark and JL Conklin. Iowa City, IA

April 1998

P R O G R A M OF THE ANNUAL M E E T I N G P3

A G A P O S T E R S E S S I O N - - S U N D A Y , MAY 17, 1998 DDW Poster of Distinction: Effects of selective p h o s p h o d i e s t e r a s e i n h i b i t o r s o n the o p o s s u m l o w e r e s o p h a g e a l s p h i n c t e r . (Abstract# G3350) MA Osinski, P Bass and EA Gaumnitz. Madison, WI

DDW Poster of Distinction: Nitric oxide i n h i b i t s acetylcholine released at the n e u r o m u s c u l a r j u n c t i o n s of m o u s e c r u r a l d i a p h r a g m . (Abstract# G3264) J Liu, EH Middlekauff, HC Lee, YI Kim and RK Mittal. Charlottesville, VA and Madison, WI

DDW Poster of Distinction: The i n f l a m m a t o r y cytokines ILI~ a n d IL6 i n h i b i t n e u r a l l y m e d i a t e d b u t n o t myogenic c o n t r a c t i o n of cat esophagus. (Abstract# G3019) W Cao, H Rich, C Fiocchi, J Behar and P Biancani. Providence, RI and Cleveland, OH

DDW Poster of Distinction: MAP k i n a s e m e d i a t e s P K C - d e p e n d e n t c o n t r a c t i o n of cat LES a n d esophageal c i r c u l a r smooth muscle. (Abstract# G3018) W Cao, UD Sohn, J Behar and P Biancani. Providence, RI and Seoul, Korea G r o u p I s e c r e t e d p h o s p h o l i p a s e A2 mediates LES t o n e i n the cat. (Abstract# G3017) W Cao, KM Harnett, MK Jain, J Behar and P Biancani. Providence, RI and Newark, DE Effect of a n N-methyl-D-aspartate r e c e p t o r a n t a g o n i s t o n t r a n s i e n t l o w e r esophageal s p h i n c t e r r e l a x a t i o n s i n t h e dog. (Abstract# G3239) A Lehmann. M61ndal, Sweden A t r o p i n e i n d u c e s p a r a d o x i c a l r e s p o n s e of lower esophageal s p h i n c t e r to caerulein. (Abstract# G3465) T Sugawara, S Fukudo and M Hong0. Sendai, Japan

MOTILITY AND N E R V E - G U T I N T E R A C T I O N S - E S O P H A G E A L MOTILITY: CLINICAL SCIENCE

DDW Poster of Distinction: The role of esophageal t o n e i n n o n - c a r d i a c chest p a i n r e v i v a l of t h e e d r o p h o n i u m test? (Abstract# G2985) M Bittinger, J Barnett, S Doesel and M Wienbeck. Augsburg, Germany

DDW Poster of Distinction: Sumatriptan maintains the postprandial increase in t r a n s i e n t lower esophageal s p h i n c t e r r e l a x a t i o n s a n d increases gastroesophageal reflux i n n o r m a l subjects. (Abstract# G3441) D Sifrim, RH Holl0way, T Missotten, A Zelter, J Tack and J Janssens. Adelaide, Australia and Leuven, Belgium

DDW Poster of Distinction: Gastroesophageal reflux i n diabetes mellitus. (Abstract# G3313) F Mora, I Lluch, J Ascaso, I Pascual, V Sanchis, M Minguez, A Pefia and A Benages. Valencia, Spain

DDW Poster of Distinction: Effect of loxiglumide o n l o w e r esophageal s p h i n c t e r m o t o r e v e n t s a n d gastric r e l a x a t i o n i n d u c e d b y d u o d e n a l i n f u s i o n of a l i q u i d meal i n h e a l t h y subjects. (Abstract# G3541) F Zerbib, S Bruley des Varannes, M D'Amato, C Scarpignato and JP Galmiche. Nantes, France and Monza, Italy

DDW Poster of Distinction: I n c o n s t a n t association of esophageal symptoms, p s y c h o m e t r i c a b n o r m a l i t i e s , a n d dysmotility. (Abstract# G3448) CW Song, SJ Lee, CD Kim, HS Ryu, JH Hyun and PJ Kahrilas. Seoul, Korea and Chicago, IL

S e c o n d a r y esophageal peristalsis. E v i d e n c e for a n e u r o m u s c u l a r afferent p a t h w a y . (Abstract# G3426) JH Schneider, JH Peters, HD Becket, CG Bremner and TR DeMeester. Los Angeles, CA and Tfibingen, Germany

Effect of CCK-A r e c e p t o r b l o c k a d e o n p o s t p r a n d i a l gastroesophageal reflux i n d u c e d b y e n d o g e n o u s CCK i n h e a l t h y h u m a n s . (Abstract# G3031) P Clave, A Gonzfilez, R L6pez, I Marti, J Monks, M D'Amato and F Lluis. Balcelona and Monza, Italy

R e g i o n a l differences i n the r e s p o n s e of cat esophageal b o d y c i r c u l a r m u s c l e to s t r e t c h a n d b e t h a n e c h o l s t i m u l a t i o n . (Abstract# G3534) S Xue and NE Diamant. Toronto, Canada

Cause a n d course of chest p a i n i n p a t i e n t s w i t h achalasia. (Abstract# G3086) VF Eckardt, B Stauf and G Bernhard. Wiesbaden, Germany

T o p o g r a p h i c m a n o m e t r i c a n a l y s i s also reveals s e q u e n t i a l esophageal c o n t r a c t i o n segments i n the opossum. (Abstract# G3033) RE Clouse, RA Underwood, LR Haroian, A Alrakawi, C Prakash and NJ Soper. St Louis, MO Collagens, f i b r o n e c t i n a n d v e r s i c a n i n smooth muscle of o p o s s u m esophagus. (Abstract# G3283) JB Martin, SS Shirazi and K Schulze-Delrieu. I0wa City, IA F u n c t i o n a l s t u d i e s of the m o t o r i n n e r v a t i o n of the u p p e r e s o p h a g e a l s p h i n c t e r i n t h e cat. (Abstract# G3227) IM Lang, B Medda and R Shaker. Milwaukee, WI Nitric oxide r e p l a c e m e n t p r o d u c e s a r e b o u n d LES c o n t r a c t i o n after i n i t i a l r e l a x a t i o n i n achalasia. (Abstract# G3288) BT Massey, JM Gorny and C Hofmann. Milwaukee, WI Contraction induced by phosphatase inhibitors in esophageal a n d LES s m o o t h muscle. (Abstract# G3201) N Kim, IS Song, CY Kim, KM Harnett and P Biancani. Seoul, Korea and Providence, RI

Botulinum toxin injection improves symptomatic h y p e r t e n s i v e lower esophageal s p h i n c t e r . (Abstract# G3289) S Mathews, H Cohen and M Kline. Los Angeles, CA E s o p h a g e a l m o t i l i t y of p a t i e n t s w i t h different grades of esophageal i n v o l v e m e n t b y Chagas' disease. (Abstract# G3056) RO Dantas, NHS Deghaide and EA Donadi. Ribeirg0 Preto, Brazil E s o p h a g e a l motility d i s o r d e r s i n "esophagus free s y m p t o m " HIV p a t i e n t s . (Abstract# G3296) S Mazzadi, G Salis, AO Garcia, N Gallo, N Sarmiento, L Daciuk, H Laplume, C Varsky and JC Chiocca. Haed0, Argentina Are s e n s o r y a n d m o t o r r e s p o n s e s to esophageal d i s t e n s i o n of the p r o x i m a l a n d distal s e g m e n t s i n f l u e n c e d b y body d i m e n s i o n s ? (Abstract# G2967) JD Barlow, DG Thompson and H Gregersen. Manchester, United Kingdom and Aarhus, Denmark

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S u m a t r i p t a n , a 5HT 1 a g o n i s t , i n c r e a s e s g a s t r o e s o p h a g e a l reflux. (Abstract# G3107) JM Foster, LA Houghton and PJ WhorweU. Manchester, United Kingdom

Upper esophageal sphincter function during g a s t r o e s o p h a g e a l r e f l u x events. (Abstract# G3481) S Torrico, J Ren, Z Sui, C Hofmann and R Shaker. Milwaukee, WI

Alesotron, a n e w 5HT a a n t a g o n i s t h a s no a d v e r s e effects on e s o p h a g e a l m o t i l i t y o r l o w e r e s o p h a g e a l s p h i n c t e r p r e s s u r e . (Abstract# G3199) R Khoury, P Peghini, P Katz and D Castell. Philadelphia, PA

D e g l u t i t i v e LES r e l a x a t i o n c h a r a c t e r i s t i c s u s i n g a s t a n d a r d i z e d sleeve s e n s o r m e t h o d o l o g y a n d c o m p u t e r a s s i s t e d a n a l y s i s . (Abstract# G3093) GA Ergun, G Shi and PJ Kahrflas. Chicago, IL

E s o p h a g e a l m o t i l i t y d i s o r d e r s i n HIV p a t i e n t s . (Abstract# G3539) A Zalar, M Olmos, E Piskorz and F Magnanini. Buenos Aires, Argentina E x p a n d a b l e m e t a l s t e n t s i n a c h a l a s i a - is t h e r e a role? (Abstract# G3320) S Mukherjee, M Sipple and DS Kaplan. Syracuse, NY The effect of c l i n i c a l l y u s e d doses of g l u c a g o n on e s o p h a g e a l m o t i l i t y of n o r m a l subjects. (Abstract# G3040) V Colon, A Grade, G Pul]iam and R Fass. Tucson, AZ C o m p a r i s o n o f t w o t e c h n i q u e s for l o w e r e s o p h a g e a l sphincter manometry: dentsleeve and sphinctometer. (Abstract# G3461) JWA Straathof, M Lfichtenb0rg, CBHW Lamers and AAM Masclee. Leiden, The Netherlands M u l t i c e n t e r , d o s e - f i n d i n g s t u d y of b o t u l i n u m t o x i n for t h e t h e r a p y of e s o p h a g e a l a c h a l a s i a . (Abstract# G2949) V Annese, G Bassotti, G Coccia, M Dinelli, V D'On0fri0, G Gatto, P Repici and A Andriulli. San Giovanni Rotond0, Italy Secondary motor activity, mainly non-peristaltic, in the h e a l t h y e s o p h a g u s . (Abstract# G2947) A Anggiansah, REK Marshall and WJ Owen. London, United Kingdom The n u t c r a c k e r e s o p h a g u s : is t h i s a r e s p o n s e to e s o p h a g e a l o u t f l o w o b s t r u c t i o n ? (Abstract# G3504) LN Veligati, JM Gorny and BT Massey. Milwaukee, WI The effect of s l e e p o n p r o x i m a l e s o p h a g e a l m i g r a t i o n of i n f u s e d acid. (Abstract# G3348) WC Orr, MJ Harnish and S Elsenbruch. Oklahoma City, OK; Birmingham, AL P a r a m e t e r s of p r o x i m a l e s o p h a g e a l a c i d m i g r a t i o n . (Abstract# G3347) WC Orr, MJ Harnish and S Elsenbruch. Oklahoma City, OK; Birmingham, AL A n e w s t a n d a r d i z e d m e t h o d for m e a s u r e m e n t of t h e l o w e r e s o p h a g e a l s p h i n c t e r . . ( A b s t r a c t # G3016) GMR Campos, PF Crookes, S Oberg, OL Gastal, J Theisen, J Nigro, CG Bremner, JH Peters and TR DeMeester. Los Angeles, CA C h a r a c t e r i z a t i o n of e s o p h a g e a l s t r i a t e d m u s c l e i n p a t i e n t s w i t h a c h i a s i a . (Abstract# G3081) PM Dunaway, CL Maydonovitch and RKH Wong. Washington, DC The m o t o r f u n c t i o n s t h e h u m a n e s o p h a g e a l b o d y a n d lower esophageal sphincter are regulated by cervical a n d t h o r a c i c s y m p a t h e t i c g a n g l i a (SG): f u n c t i o n a l effects o f a c o m p u t e r t o m o g r a p h y - g u i d e d selective SG block. (Abstract# G3514) T yon Schrenck, U Matsui, S Kirchhof, C Bobrowski, H Beck, A Nierhaus, U Rust, H Ohnesorge, V Nicolas, J Schulte am Esch and H Greten. Hamburg, Germany

Effect of c i s a p r i d e on 1° a n d 2 ° e s o p h a g e a l c l e a r a n c e forces in s u b j e c t s w i t h a n d w i t h o u t GERD. ( A b s t r a c t # G3452) AE Spiess, M Manka and PJ Kahrilas. Chicago, IL I n c r e a s e d g a s t r o e s o p h a g e a l r e f l u x in d i a b e t e s m e l l i t u s . (Abstract# G3104) H Fischer, T Heidemann, K Hengst, W Domschke and JW Konturek. Muenster, Germany C h a r a c t e r i s t i c s of u p p e r e s o p h a g e a l s p h i n c t e r relaxation in healthy premature infants. (Abstract# G3344) T Omari, A Snel, C Barnett, G Davidson, R Haslam, M Bakewell and J Dent. Adelaide, Australia Effects of p o s i t i o n a n d m o d e of v e n t i l a t i o n o n esophageal acid exposure after abdominal surgery. (Abstract# G3507) E Verdier, JL Pandolfi, L Muller, JY Lefrant and P P0uderoux. Nimes, France IMMUNOLOGY, MICROBIOLOGY, A N D I N F L A M M A T O R Y D I S O R D E R S - - N I T R I C OXIDE AND I N F L A M M A T I O N

DDW Poster of Distinction: S y n t h e s i s o f n i t r i c oxide i n t h e p a r a v e n t r i c u l a r n u c l e u s of t h e h y p o t h a l a m u s a n d i n t h e d o r s a l m o t o r n u c l e u s of t h e vagus m e d i a t e s t h e a c i d i n h i b i t o r y effects o f c e n t r a l l y a d m i n i s t e r e d b o m b e s i n . (Abstract# G3808) B Beltr~n, S Calatayud, S Vald6s, MC Ramirez and JV Esplugues. Valencia, Spain The i n h i b i t i o n b y c e n t r a l b o m b e s i n of p e r i p h e r a l s t i m u l a t i o n of g a s t r i c s e c r e t i o n involves t h e r e l e a s e of n i t r i c oxide in t h e d o r s a l m o t o r n u c l e u s of t h e vagus. (Abstract# G0289) B Beltr~in, MD Barrachina, R Bello, S Calatayud and JV Esplugues. Valencia, Spain Nitric o x i d e p r o d u c t i o n is r e g u l a t e d b y t r a n s f o r m i n g g r o w t h factor-~ i n r a t s p l e n o c y t e s a f t e r b i l e d u c t ligation. (Abstract# G4179) M Leong, D Murasko, 0 Pankewycz and K Kahng. Philadelphia, PA P r e v e n t i o n of r a t d u o d e n a l e p i t h e l i a l cell i n j u r y p r o v o k e d b y p u r i f i e d Helicobaeterpylori l i p o p o l y s a c c h a r i d e b y t h e h i g h l y selective i n h i b i t o r of i n d u c i b l e n i t r i c oxide s y n t h a s e , 1400W. (Abstract# G4487) Z Szepes, D Lamarque, A Moran, JC Delchier and BJR Whittle. Creteil, France; Galway, Ireland and London, United Kingdom Histologically n o r m a l colonic b i o p s i e s f r o m p a t i e n t s w i t h colitis b e h a v e like i n f l a m e d colon n o t b o w e l f r o m h e a l t h y i n d i v i d u a l s : s t e r o i d s e n s i t i v i t y of IL-8 a n d n i t r i c o x i d e p r o d u c t i o n . (Abstract# G4189) JD Linehan, JB Leithead, DA Robertson and J Westwick. Bath, United Kingdom

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A G A P O S T E R S E S S I O N - - S U N D A Y , MAY 17, 1998 Are m o n o n u c l e a r cells t h e site of a c t i o n of steroids a n d " a n t i i n f l a m m a t o r y " cytokines i n colitis? (Abstract# G4187) JD Linehan, DA Robertson and J Westwick. Bath, United Kingdom C y t o k i n e i n d u c t i o n of i n d u c i b l e n i t r i c oxide s y n t h a s e is i n h i b i t e d b y m e s a l a m i n e i n r a t small i n t e s t i n a l e p i t h e l i a l cells. (Abstract# G4514) JF Valentine. Gainesville, FL S y n e r g i s t i c effects of m u l t i p l e cytokines on n i t r i c oxide p r o d u c t i o n a n d p e r m e a b i l i t y of c u l t u r e d CaCo-2Bb e (enterocytic) m o n o l a y e r s . (Abstract# G3895) AM Chavez, MJ Menc0ni, RA Hodin and MP Fink. Boston, MA Multiple c y t o k i n e s i n d u c e gut n i t r i c oxide p r o d u c t i o n b y two d i s t i n c t m e c h a n i s m s . (Abstract# G3894) AM Chavez, MJ Menconi, MP Fink and RA Hodin. Boston, MA The role of n i t r i c oxide i n the p a t h o g e n e s i s of d u o d e n a l u l c e r i n d u c e d b y c y s t e a m i n e i n rats. (Abstract# G4553) ZF Wen, CH Ch0, KC Lai and SK Lain. Hong K0ng, China E l e c t r o n p a r a m a g n e t i c r e s o n a n c e spectroscopic studies of i n t e s t i n a l h o m o g e n a t e s from NSAIDs-treated rats. (Abstract# G4451) S Somasundaram, S Raft, JK ShergiU, J Wrigglesworth and I Bjarnason. London, United Kingdom and Seattle, WA iNOS is expressed b y u n s t i m u l a t e d h u m a n d u o d e n a l e n t e r o c y t e s in witro w i t h i n c r e a s e d expression i n disease. (Abstract# G4280) IA Murray, K Coupland, ID Daniels, WP Goddard and RG Long. Nottingham, United Kingdom G e n e r a t i o n of n i t r i c oxide activity i n macrophagei n t e s t i n a l e p i t h e l i a l cell cocultures. (Abstract# G4231) CA Martin, M DeGaetano, Y M0sk0witz and R Burak0ff. Mineola and Stony Brook, NY E p i t h e l i a l n i t r i c oxide e x p r e s s i o n i n i n f l a m m a t o r y bowel disease: a n oxidative b a r r i e r of the i n f l a m e d m u c o s a ? (Abstract# G3957) G Dijkstra, HM van Dullemen, H Moshage, A de JagerKrikken, ATMG Tiebosch, PLM Jansen and H van G0or. Groningen, The Netherlands Effects of l u m i n a l NG-nitro-L-arginine o n mucosal n i t r i c oxide, ileal f u n c t i o n a n d s u r v i v a l after IV l i p o p o l y s a c c h a r i d e i n t h e a n e s t h e t i z e d rat. (Abstract# G4222) D Mailman. Houston, TX C y t o k i n e - s t i m u l a t e d n i t r i c oxide p r o d u c t i o n b y CaCo-2 h u m a n colonic e p i t h e l i a l cells is n o t i n h i b i t e d by the corticosteroid, d e x a m e t h a s o n e . (Abstract# G3892) M Cavicchi and BJR Whittle. London, United Kingdom Rectal m e a s u r e m e n t s of n i t r i c oxide i n i n f l a m m a t o r y bowel disease. (Abstract# G4071) M Herulf, T Ljung, PM Hellstr6m, E Weitzberg and J Lundberg. Stockholm, Sweden IMMUNOLOGY, MICROBIOLOGY, AND INFLAMMATORY DISORDERS - - IBD: INFLAMMATION AND N O N I M M U N E CELLS D D W Poster o f Distinction: IGF-I a n d I G F - b i n d i n g protein-5 i n Crohn's disease: (Abstract# G4184) L Li, PK Lund, J Pucilowska and EM Zimmermann. Ann Arbor, MI and Chapel Hill, NC

S L P I s u p p r e s s e s NF-~B a c t i v a t i o n a n d IL-8 e x p r e s s i o n i n h u m a n colonic e p i t h e l i a l cells. (Abstract# G4348) TT Pizarro, MS Le and F Cominelli. Charlottesville, VA

P r o s t a g l a n d i n H synthase-2 i n d u c t i o n b y h y d r o x y e i c o s a t e t r a e n o i c acids (HETES) i n a n i n t e s t i n a l s u b p i t h e l i a l m y o f i b r o b l a s t cell line. (Abstract# G4393) JI Saada, JD Valentich, RC Mifflin and DW Powell. Galveston, TX Does IL-6 c o n t r i b u t e to o s t e o p e n i a i n c h i l d r e n w i t h Crohn's disease? (Abstract# G4486) FA Sylvester, N Wyzga, JS Hyams and GA Gronowicz. Hartford and Farmington, CT Glucocorticoid r e c e p t o r c h a r a c t e r i s t i c s , n u c l e a r t r a n s l o c a t i o n a n d m o l e c u l a r effects i n h a m a n i n t e s t i n a l smooth m u s c l e cells. (Abstract# G4045) M Graham, A Willey, Y Zhu, J Schreher, R Witorsch and H Sugerman. Richmond, VA I n d u c e d e x p r e s s i o n of syndecan-1 i n r e p a r a t i v e e p i t h e l i u m i n v/fro. (Abstract# G3937) R Day and A Forbes. Harrow, United Kingdom Loss of h e p a r a n sulfate m e d i a t e d basic fibroblast growth factor b i n d i n g is r e s t o r e d b y h e p a r i n . (Abstract# G3938) R Day and A Forbes. Harrow, United Kingdom Expression of i n t e r l e u k i n - 1 5 b y h u m a n i n t e s t i n a l muscle cells a n d i n the m u s c u l a r l s exteraa d u r i n g disease states. (Abstract# G4210) P L0vato, BA Vallance and SM Collins. Hamilton, Canada Expression of MMP14 ( m e m b r a n e - t y p e - l - m a t r i x metalloproteinase) is i n c r e a s e d i n i n f l a m e d colon mucosa of p a t i e n t s w i t h i n f l a m m a t o r y bowel diseases. (Abstract# G4546) B v0n Lampe, B Barthel, EO Riecken and S Rosewicz. Berlin, Germany Q u a n t i t a t i v e analysis of MUC2 s e c r e t i o n i n u l c e r a t i v e colitis. (Abstract# G4525) BJW van Klinken, AWC Einerhand, JWG van der Wal, HA Biiller and J Dekker. Amsterdam and Rotterdam, The Netherlands Isolation a n d c h a r a c t e r i z a t i o n of i m m o r t a l i z e d enteroglial cell l i n e s from the m y e n t e r i c plexus of a d u l t rat. (Abstract# G4392) A R(ihl, B Denefleh and W Stremmel. Heidelberg, Germany P r o s t a n o i d p r o d u c t i o n i n h u m a n i n f l a m m a t o r y bowel disease is d e p e n d e n t u p o n cyclooxygenase 2: use of selective i n h i b i t o r s . (Abstract# G4242) SA McCartney, JA Mitchell, I Vojnovic, MJG Farthing and TD Warner. London, United Kingdom The selective cyclooxygenase-2 i n h i b i t o r DFU does n o t suppress p r o s t a g l a n d i n E2 f o r m a t i o n i n colonic mucosa of p a t i e n t s w i t h active C r o h n ' s disease. (Abstract# G4049) B Gretzer, T Griga, L Barbera and BM Peskar. Bochum, Germany Differential mucosal e x p r e s s i o n of s u p e r o x i d e d i s m u t a s e isoforms i n i n f l a m m a t o r y bowel disease. (Abstract# G4150) L Kruidenier, G Kuiper, SL Marklund, CBHW Lamers and HW Verspaget. Leiden, The Netherlands and Ume~, Sweden

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D o u b l e - s t r a n d e d RNA (poly I:C) u p r e g u l a t e s m u s c u l a r i s m u c o s a e cell a d h e s i v e n e s s for m o n o n u c l e a r l e u k o c y t e s through a favored hyaluronan/CD44 mechanism. (Abstract# G3941) CA de la Motte, A Calabro, VC Hascall and SA Strong. Cleveland, OH Is t h e a n t i i n f l a m m a t o r y a c t i o n of m e t h o t r e x a t e m e d i a t e d b y a d e n o s i n e ? (Abstract# G3981) LJ Egan, WJ Sandborn, DC Mays, WJ Tremaine and J J Lipsky. Rochester, MN

DDW Poster of Distinction: D i a l y s i s of t h e r e c t u m for s a m p l i n g a n exogenous molecule, m e t h o t r e x a t e a n d a n e n d o g e n o u s molecule, p o t a s s i u m : t e c h n i q u e a n d v a l i d a t i o n . (Abstract# G3979) LJ Egan, WJ Sandborn, DC Mays, WJ Tremaine and J J Lipsky. Rochester, MN I n c r e a s e d p r o d u c t i o n of s t r o m e l y s i n (MMP3) b y i n f l a m e d colonic m u c o s a i n i n f l a m m a t o r y b o w e l disease. (Abstract# G4205) E Louis, M Malaise and J Belaiche. Liege, Belgium N e u r o t r o p h i n e x p r e s s i o n i n t h e a d r e n a l g l a n d in e x p e r i m e n t a l colitis s u g g e s t s a n e u r o e n d o c r i n e r e g u l a t o r y p a t h w a y . (Abstract# G4002) G Fl~mig, H Rohm, I Geerling, G Adler and M Reinshagen. Ulm, Germany I M M U N O L O G Y , MICROBIOLOGY, A N D I N F L A M M A T O R Y D I S O R D E R S - - IBD: D I S E A S E ASSESSMENT I n t e s t i n a l p e r m e a b i l i t y a n d i n f l a m m a t i o n in Crohn's d i s e a s e a n d t h e i r f i r s t d e g r e e r e l a t i v e s . (Abstract# G4494) B Thjodleifsson, G Sigthorsson, A Gunnarsdottir, H Norland, E Oddsson, H Gudjonsson, S Einarsson, J Meddings, A Roseth, MK Fagerhol, R Crane, M Kjeld and I Bjarnason. Iceland; Calgary, Canada; Ulleval, Norway and London, United Kingdom A s s e s s m e n t of i n t e s t i n a l o x a l a t e a b s o r p t i o n in p a t i e n t s with Crohn's disease using a new stable isotope t e c h n i q u e . (Abstract# G4413) C Scheurlen, L Schneider, GE yon Unruh, MAW Langer, A Hesse and T Sauerbruch. Bonn, Germany V a s c u l a r i z a t i o n a n d v a s c u l a r r e s i s t a n c e in t h e i n t e s t i n a l w a l l i n i n f l a m m a t o r y b o w e l d i s e a s e as a sign for d i s e a s e activity. (Abstract# G4073) R Heyne, S Schreiber, S Wedel, H Lochs and W Wermke. Berlin, Germany E v i d e n c e of s y s t e m i c m a s t cell a c t i v a t i o n i n Crohn's disease. (Abstract# G4560) S Winterkamp, M Weidenhiller, POtte, J Stolper, D Schwab, M Raithel and EG Hahn. ErlangenNuremberg, Germany

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17, 1998

DDW Poster of Distinction: A n e w t e c h n i q u e of m a g n e t i c r e s o n a n c e i m a g i n g in t h e m a n a g e m e n t of p a t i e n t s w i t h C r o h n ' s disease. (Abstract# G4544) A Viscid0, M Marrollo, F Maccioni, L Broglia, P Torchio, P Rossi and R Caprilli. Rome and Milan, Italy

DDW Poster of Distinction: A c o m p a r i s o n of u l t r a s o u n d a n d d o u b l e X-ray b o n e d e n s i t o m e t r y i n i n f l a m m a t o r y b o w e l disease. (Abstract# G4230) A Martin, M Dinca, W Fries, G Luisetto, F Peccolo, F Bottega, A Rizzo and R Naccarato. Padua, Italy Doppler sonographic assessment of vessel density in t h e d i s e a s e d b o w e l in p e d i a t r i c C r o h n ' s disease. (Abstract# G4458) JH Spalinger, H Patriquin, D Herzog and EG Seidman. Montreal, Canada U l t r a s o n o g r a p h i c f i n d i n g s i n i n f l a m m a t o r y bowel diseases: a n a n a l y s i s of i n t e r - a n d i n t r a - o b s e r v e r v a r i a t i o n . (Abstract# G3782) V Arienti, L Arffili, L Boriani, C Califano, A Domanico, MG Covarelli and ME Summarro. Bologna, Italy Reliability of technetium-99m-hexamethyl propylene a m i n e oxime-labelled l e u k o c y t e s c i n t i g r a p h y i n c l i n i c a l e v a l u a t i o n of i n f l a m m a t o r y b o w e l disease. (Abstract# G4272) E Moreno-Osset, J Ballester, JM Paredes, R Puchades, L de la Cueva, M Urefia, R Sopena, A Cremades and T Ripoll~s. Valencia, Spain H y d r o c o l o n i c s o n o g r a p h y i n t h e e v a l u a t i o n of active i n f l a m m a t o r y b o w e l disease. (Abstract# G4405) M Sans, C Bru, J Pan6s, J Llach, D Fuster, R Gilabert, MM Defelitte, F Lomefia, JM Bordas and JM Pique. Barcelona, Spain Active Crohn's d i s e a s e a n d u l c e r a t i v e colitis e v a l u a t e d b y m a g n e t i c r e s o n a n c e imaging. (Abstract# G4218) SM Madsen, HS Thomsen, P Munkholm, S Dorph and P Schlichting. Copenhagen, Denmark C o m p a r i s o n of m a g n e t i c r e s o n a n c e i m a g i n g w i t h s u p e r p a r a m a g n e t i c o r a l c o n t r a s t a n d e n d o s c o p y in t h e e v a l u a t i o n of e x t e n t a n d a c t i v i t y of u l c e r a t i v e colitis. (Abstract# G3933) A D'Arienzo, G Belfiore, G Scaglione, G Vicinanza, M Imbriaco, F Manguso, R Bennato, M Romano, M Sanges and G Mazzaeca. Naples, Italy D e t e c t i o n of f u n c t i o n a l a n d m o r p h o l o g i c b r a i n a b n o r m a l i t i e s in i n f l a m m a t o r y b o w e l d i s o r d e r s u s i n g event-related evoked potential and magnetic resonance t o m o g r a p h y . (Abstract# G4085) S Hollerbach, F Kullmann, U Strauch, G Lock, M Wimmer, J Sch{ilmerich and T Andus. Regensburg, Germany

DDW Poster of Distinction: E v a l u a t i o n of fecal t u m o r n e c r o s i s factor-cL as a m a r k e r of C r o h u ' s d i s e a s e activity. (Abstract# G4457) JC Soul~, C Andant, N Kapel and JC Gobert. Paris, France E l e v a t e d t r a n s c o b a l a m i n I I i n p a t i e n t s w i t h Crohn's disease: i n t e s t i n a l m i c r o v a s c u l a r e x p r e s s i o n . (Abstract# G3823) DG Binion, S Seetharam and B Seetharam. Milwaukee, WI

Double-positive a n t i - s a c c h a r o m y c e s t e s t is 100% d i s e a s e specific for p e d i a t r i c Crohn's d i s e a s e . (Abstract# G4389) FM Ruemmele, SR Targan, J Braun and EG Seidman. Montreal, Canada and Los Angeles, CA S t r a t i f i c a t i o n of Crohn's d i s e a s e b y anti-Saccbaromyccs cereviMae m a n n a a n t i b o d i e s a n d a n t i n e u t r o p h i l c y t o p l a s m i c a n t i b o d i e s . (Abstract# G3893) G Charrier, B Sendid, JF Quinton, D Reumaux, B Grandbastien, A Cortot, D Poulain and JF Colornbel. Lille, France

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PROGRAM OF THE ANNUAL MEETING P43

A G A P O S T E R S E S S I O N - - S U N D A Y , M A Y 17, 1998

Serologic a n a l y s i s p e r m i t s d i f f e r e n t i a t i o n of Crohn's disease from u l c e r a t i v e colitis. (Abstract# G3763) J Aisenberg, G Zelman, C Bodian and D Sachar. New York, NY

The C r o h n ' s disease activity assessment. (Abstract# G4154) Z Krznari~, R Ostoji~, B Vuceli~ and M Opa~i~. Zagreb, Croatia

C o n f i r m a t i o n of the i m p o r t a n c e of anti-Saccharomyces cerevlsiae a n t i b o d i e s i n Crohn's disease. (Abstract# G4337) M Peeters, S Vermeire, R Dantonio, F Baert, G D'Haens, R Vlietinck, B Sendid, JF C010mbel and P Rutgeerts. Leuven, Belgium and Lille, France

I n t e s t i n a l p e r m e a b i l i t y test p r e d i c t s the clinical course i n Crohn's disease p a t i e n t s i n r e m i s s i o n : c o m p a r i s o n with i n f l a m m a t o r y indexes. (Abstract# G3960) R D'Inc~, V Di Leo, G Corrao, D Martines, A D'Od0ric0, C Mestriner, G Longo and GC Sturniolo. Padua, Milan and Messina, Italy

T u m o r n e c r o s i s factor microsatellite h a p l o t y p e a11b4cld3e3 is associated w i t h anti-sacch~eomyces cerevisiae a n t i b o d y across clinical forms of i n f l a m m a t o r y bowel disease. (Abstract# G4492) KD Taylor, Z Li, M Barry, N Fischel-Gh0dsian, SE Plevy, JI Rotter, SR Targan and H Yang. Los Angeles and San Diego, CA

IBD: d i a g n o s t i c changes a n d clinical f e a t u r e s over a four y e a r period. Results of t h e E u r o p e a n prospective s t u d y o n i n f l a m m a t o r y bowel disease. (Abstract# G4527) EHJ van Wijlick, J Lennard-Jones, S Shivananda, RW Stockbrfigger and MGVM Russel. Maastricht, The Netherlands

Serologic d i a g n o s i s of u l c e r a t i v e colitis i n P u e r t o Ricans: c o r r e l a t i o n of UC-Dx-1 a n d CD-DX-1 with clinical diagnosis. (Abstract# G4503) EA Torres and M Cruz. San Juan, PR

Risk factors for c a n c e r or d y s p l a s i a i n u l c e r a t i v e colitis with p r i m a r y sclerosing cholangitis. (Abstract# (]4170) BA Lashner, K Shetty, L Rybicki and A Brzezinski. Cleveland, OH

G e o g r a p h i c d i s t r i b u t i o n of microscopic colitis: i m p l i c a t i o n s for endoscopic diagnosis. (Abstract# G3766) O Alkhatib, JB Fisher, M Tinaw and PL Moses. Burlington, VT and Ann Arbor, MI

Diagnoses of e x t r a i n t e s t i n a l m a n i f e s t a t i o n s a n d cancers i n IBD i n large p o p u l a t i o n - b a s e d databases. (Abstract# G3814) CN Bernstein, E Kliewer, P Rawsthorne, W Doig and JF Blanchard. Winnipeg, Canada

Differential c h a n g e s of basic fibroblast growth factor a n d p l a t e l e t - d e r i v e d g r o w t h factor i n h u m a n s e r u m a n d b i o p s y s a m p l e s i n u l c e r a t i v e colitis a n d Crohn's disease. (Abstract# G4402) Z Sandor, S Szabo, M Szathmari, T Zagoni and Z Tulassay. Irvine and Long Beach, CA; Budapest, Hungary

The effects of s m o k i n g o n t h e d e v e l o p m e n t of i n f l a m m a t o r y bowel disease. (Abstract# G3863) S Bridget, C McGregor, IC Forgacs, I Bjarnason and AJS Macpherson. London, United Kingdom

S e r u m t r a n s g l u t a m i n a s e correlates w i t h endoscopical and histopathologieal grading in patients with u l c e r a t i v e colitis. (Abstract# G3932) G D'Argeni0, V Cosenza, N Della Valle, F De Ritis and G Mazzacca. Naples, Italy I n c r e m e n t of t h e n u m b e r of a b e r r a n t c r y p t loci i n u l c e r a t i v e colitis p a t i e n t s . (Abstract# G4398) S Sakamaki, S Katsuki, T Takayama, N Y0shizaki, M Ohi, J N0buoka, N Takayanagi and N Niitsu. Sapporo, Japan E v a l u a t i o n of a c t i v i t y i n u l c e r a t i v e colitis: who is r i g h t the c l i n i c i a n , endoscopist or pathologist? (Abstract# G4220) U Mahadevan, PH Rubin, NA Harpaz, E Goldstein and DH Present. New York, NY

Early i n f e c t i o n with measles v i r u s is associated w i t h a n i n c r e a s e d r i c k of u l c e r a t i v e colitis. (Abstract# G4330) DS Pardi, WJ Tremaine, WJ Sandborn, EV Loftus, Jr, GA Poland, AR Zinsmeister and LJ Melton. Rochester, MN Reliability of a Crohn's disease clinical classification scheme b a s e d o n disease b e h a v i o r . (Abstract# G4038) N Girgrah, RS McLeod and AH Steinhart. Toronto, Canada Are c o n c u r r e n t measles a n d m u m p s i n f e c t i o n s i n childhood a r i s k for i n f l a m m a t o r y bowel disease? (Abstract# G4268) SM Montgomery, DL Morris, RE Pounder and AJ Wakefield. London, United Kingdom

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E x ~ v o a u t o r a d i o g r a p h y a n d FACS-scan analysis d e m o n s t r a t i o n of a specific b i n d i n g b e t w e e n IL2r e c e p t o r positive cells i n Crohn's disease gut a n d 123Ii n t e r l e u k i n - 2 i n j e c t e d in vivo. (Abstract# G3818) L Biancone, A Signore, G Ronga, P PozziUi and F PaUone. Rome and Catanzaro, Spain Is c h i l d h o o d C r o h n ' s disease a r e a s o n a b l e i n d i c a t i o n for e s o p h a g o g a s t r o d u o d e n o s c o p y ? (Abstract# G3917) G C0remans, N Ectors, I Hoffman and G VeeremanWauters. Leuven, Belgium Focal g a s t r i t i s i n C r o h n ' s disease: prevalence, i m m u n o h i s t o c h e m i c a l characteristics, a n d c l i n i c o / a n a t o m i c a l d e t e r m i n a n t s . (Abstract# G4331) F Parente, S Bollani, C Cucin0, S Ardizzone, L Vag0, P Duca and GB Porto. Milan, Italy The effect of g e n d e r o n q u a l i t y of life i n s t r u m e n t s i n IBD. (Abstract# G3770) S A n a m and S Hanauer. Chicago, IL

C o n c u r r e n t measles a n d m u m p s epidemic i n I c e l a n d are a r i s k for later i n f l a m m a t o r y bowel diseas e. (Abstract# G4270) SM Montgomery, S BjSrnsson, JH JShannsson, B Thjodleifsson, RE Pounder and AJ Wakefield. London, United Kingdom and Reykjavik, Iceland A p p e n d e c t o m y a n d the r i s k of d e v e l o p i n g u l c e r a t i v e colitis: r e s u l t s after c o n t r o l of s m o k i n g factor. (Abstract# G4292) SW Nam, S-K Yang, H-Y Jung, SH Yang, SY Kim, HJ Kim, W-S Hong and YI Min. Seoul, Korea V a l i d a t i o n of a disease specific h e a l t h - r e l a t e d q u a l i t y of life i n s t r u m e n t for p e d i a t r i c i n f l a m m a t o r y bowel disease. (Abstract# G4006) S Forget, R Cawdron, RM Issenman, N Gold and EJ Irvine. Hamilton and Montreal, Canada Health-related q u a l i t y of life i n p e d i a t r i c i n f l a m m a t o r y bowel disease: a c o m p a r i s o n of p a r e n t a n d child reports. (Abstract# G4005) S Forget, G Norman, RM Issenman, N G01d and EJ Irvine. Montreal and Hamilton, Canada

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Cross-cultural variation in disease-related concerns a m o n g p a t i e n t s w i t h i n f l a m m a t o r y b o w e l disease. (Abstract# G4182) S Levenstein, Z Li and D Dr0ssman. Rome, Italy; Scottsdale, AZ and Chapel Hill, NC

Enteric viral infection in patients with the acquired i m m u n o d e f i c i e n c y s y n d r o m e - a c a u s e of d i a r r h e a ? (Abstract# G4352) RCG Pollok, P Thomas and BG Gazzard. London, United Kingdom

I n f o r m a t i o n n e e d s a n d s e e k i n g b e h a v i o r s of p a t i e n t s w i t h i n f l a m m a t o r y b o w e l disease. (Abstract# G4078) RJ Hilsden, C Dunn, S Patten, CM Scott and MJ Verhoef. Calgary, Canada

DDW Poster of Distinction:

A n i n t e r n a t i o n a l s u r v e y of t h e u s e a n d a t t i t u d e s regarding alternative medicine by patients with i n f l a m m a t o r y b o w e l d i s e a s e . (Abstract# G4368) P Rawsthorne, CC Cronin, F Shanahan, PA Anton, R L6fberg and CN Bernstein. Winnipeg, Canada; Cork, Ireland; Los Angeles, CA and Stockholm, Sweden

HIV does n o t affect o u t c o m e i n a c u t e u p p e r GI h e m o r r h a g e . (Abstract# G4069) EJ Hernandez, R Jain, JS Burdick, RH Seidel and WL Peterson. Dallas, TX

DDW Poster of Distinction: Effect of p r o t e a s e i n h i b i t o r s on t h e o u t c o m e of t h e r a p y for c h r o n i c H I V - r e l a t c d d i a r r h e a . (Abstract# G3822) EJ Bini and J Cohen. New York, NY

A c t i v a t e d p r o t e i n C r e s i s t a n c e d u e to f a c t o r V L e i d e n mutation among patients with inflammatory bowel disease: a c a s e - c o n t r o l s t u d y , (Abstract# G3780) S Ardizzone, S Bollani, P Molteni, U Russo, E Rossi and GB Porro. Milan, Italy

C o n d y l o m a t a a c u m i n a t a of t h e a n a l c a n a l t r e a t e d b y e n d o s c o p i c t o p i c a l a p p l i c a t i o n of p o d o p h y l l o t o x i n 0.5% solution. A 3-year follow-up s t u d y . (Abstract# G4509) C Tzathas, P Amperiadis, K Screpet0u and G Triantafyllou. Athens, Greece

I n v/vo m e t a b o l i s m of c o l o n i c a l l y a d m i n i s t e r e d 1-1sC. b u t y r a t e i n q u i e s c e n t h u m a n u l c e r a t i v e colitis. (Abstract# G4447) EJ Simpson, MAS Chapman, J Dawson, D Berry and AT Cole. Nottingham, United Kingdom

E r a d i c a t i o n of i n t r a c e l l u l a r i n t e s t i n a l p r o t o z o a in AIDS p a t i e n t s u s i n g h i g h dose a l b e n d a z o l e . (Abstract# G4125) P Kelly, I Zulu, S Sianongo and MJG Farthing. London, United Kingdom and Lusaka, Africa

An e p i d e m i o l o g i c a l s t u d y of u l c e r a t i v e colitis in t h e S o n g p a d i s t r i c t , Seoul, Korea. (Abstract# G4582) S-K Yang, YI Min, HY Kim, JY Yoo, PL Rhee, JC Rhee, DK Chang, IS Song, SA Jung, EB Park, HW Chung, DK Lee and YK Kim. Seoul, Korea pANCA a n d i n d e t e r m i n a t e colitis. (Abstract# G4374) J Retsky, D Matusewicz and S Hanauer. Chicago, IL IMMUNOLOGY, MICROBIOLOGY, AND INFLAMMATORY DISORDERS -- INTESTINAL INFECTIONS Phospholipid-rich buttermilk decreases the g a s t r o i n t e s t i n a l s u r v i v a l a n d t r a n s l o c a t i o n of l i s t e r i a i n r a t s . (Abstract# G4460) C Sprong, M Hulstein and R Van der Meer. Ede, The Netherlands C l o s t r i d i u m difficile p r e v a l e n c e i n AIDS p a t i e n t s w i t h d i a r r h e a i n L u s a k a , Z a m b i a c o m p a r e d w i t h p a t i e n t s in London. (Abstract# G4600) I Zulu, J Mwansa, P Kelly, A Veitch and MJG Farthing. Lusaka, Africa and London, United Kingdom Clinical t r i a l of 5 - a m i n o s a l i c y l i c a c i d i n a c u t e S h i g e l l a colitis. (Abstract# G3796) PK Bardhan, MR Islam, M Islam, D Saha, C Beglinger and N Gyr. Dhaka, Bangladesh and Basel, Switzerland E v a l u a t i o n of u l t r a s o n o g r a p h i c f i n d i n g i n t h e d i a g n o s i s of c l o n o r c h i a s i s . (Abstract# G4590) SJ Youn, NJ Kwak, SJ Kim and GS Eom. Che0ngju, Korea C o m p a r i s o n of e n z y m e l i n k e d i m m u n o s o r b e n t a s s a y a n d W e s t e r n b l o t t i n g i n t h e d e t e c t i o n of anticryptosporidial antibodies in the investigation of a w a t e r b o r n e o u t b r e a k of c r y p t o s p o r i d i o s i s . (Abstract# G4351) RCG PoUok, MM Aljenaibi, J McLauchlin, MP Kelly and MJG Farthing. London, United Kingdom

Effect of d i e t h y l h o m o s p e r m i n e u p o n n u t r i e n t a n d w a t e r b a l a n c e i n AIDS p a t i e n t s w i t h r e f r a c t o r y d i a r r h e a . (Abstract# G4559) SKG Winson and DP K0tler. New York, NY I n t e s t i n a l a b s o r p t i o n s of s a q u i n a v i r in t h e r a t : i n s i g h t s i n p o s s i b l e m e c h a n i s m s . (Abstract# G3926) CA Cuvelier, F Berlioz, SC Dautrey, C R0z~, C Carbon and R Farin0tti. Paris, France Clinical a n d r a d i o l o g i c a l f e a t u r e s s u g g e s t i v e of disseminated tuberculosis in patients with HIV-related a b d o m i n a l p a i n . (Abstract# G4317) EA O'Keefe, R Wood and A Van Zyl. Cape Town, South Africa B o d y c o m p o s i t i o n a n d m e c h a n i s m s of w e i g h t g a i n i n HIV-infected m a l n o u r i s h e d p a t i e n t s t r e a t e d w i t h i n d i n a v i r . (Abstract# G3879) F Carb0nnel, C Maslo, L Beaugerie, C Aussel, JG G0bert, PM Girard, JP Gendre, W R0zenbaum and J C0snes. Paris, France M y c o b a c t e r i u m a v i u m c o m p l e x of t h e d u o d e n u m i n t h e acquired immunodeficiency syndrome: endoscopic diagnosis in patients with and without indicative s y m p t o m s of t h e disease, (Abstract# G4531) C Varsky, D Weinstock, M B0nfanti, G Peluffo, A Zapata, A Dutack, M Merlin and M Ceresole. Buenos Aires, Argentina D e c r e a s e d p r e v a l e n c e of Helleobacterpjrlori i n f e c t i o n i n HIV p a t i e n t s is n o t a c o h o r t p h e n o m e n o n . (Abstract# G4051) M Gross, B Hangen, K Caca, JR Bogner and WG Zoller. Munich, Germany I n c o n t r a s t to HIV e n t e r o p a t h y i n h u m a n s e a r l y s m a l l i n t e s t i n a l d a m a g e i n SIV-infected r h e s u s m a c a q u e s is c h a r a c t e r i z e d b y c r y p t cell h y p e r p r o l i f e r a t i o n . (Abstract# G4083) K Hohloch, S Kewenig, T Schneider, K Lampe-Dreyer, C Stahl-Hennig, FJ Kaup, R Ullrich, A Stallmach and M Zeitz. Homburg/Saar, GSttingen and Berlin, Germany

April 1998

II

PROGRAMOF THEANNUALMEETINGP45

A G A P O S T E R S E S S I O N m S U N D A Y , M A Y 17, 1998

Role of special s t a i n s i n t h e pathologic e v a l u a t i o n of h u m a n immunodeficiencyvirus-related g a s t r o i n t e s t i n a l i n f e c t i o n s . (Abstract# G4265) KE MSnkemiiller, AH Bussian, A Lazenby and CM Wilcox. Birmingham, AL A new, r a p i d s t a i n i n g t e c h n i q u e for the detection of Microsporidia. (Abstract# G3813) OCW Berlin, C C0nteas, J Peter, C Gagne and LR Ash. Los Angeles and Santa Monica, CA AIDS a n d p a n c r e a s : a p r o s p e c t i v e clinicalm o r p h o l o g i c a l s t u d y of 109 consecutive a u t o p s i e s i n Sao Paulo, Brazil. (Abstract# G3896) EZ Chehter, MIS Duarte, MA L0ngo and AA Laudanna. S~o Paulo, Brazil HORMONES, TRANSMITTERS, GROWTH FACTORS AND T H E I R R E C E P T O R S - - PHYSIOLOGY AND CELL BIOLOGY I IL-17 r e g u l a t e s t h e a c t i v a t i o n of t h r e e d i s t i n c t MAPk i n a s e families i n i n t e s t i n a l epithelial cells. (Abstract# G4606) M Awane, RP MacDerm0tt, DK Podolsky and HC Reinecker. Boston and Burlington, MA

DDW Poster of Distinction: I n p u r i f i e d r a t p a r i e t a l cells NF-r,B is activated b y p r o i n f l a m m a t o r y c y t o k i n e s a n d H202. (Abstract# G4799) AJ Puschmann, K Dehne, S Page, M Classen and W Schepp. Munich, Germany C h a r a c t e r i z a t i o n of l a m i n a p r o p r i a lymphocytes, m a c r o p h a g e s a n d m y o f i b r o b l a s t s m i g r a t i n g out of h u m a n gastric m u c o s a d e n u d e d of epithelial cells. (Abstract# G4871) KC Wu, L Jackson, A Galvin, T Gray, CJ Hawkey and YR Mahida. Nottingham, United Kingdom M o b i l i z a t i o n of e p i t h e l i a l STAT-1 i n r e s p o n s e to m e d i a t o r s r e l e a s e d from b a c t e r i a l s u p e r a n t i g e n a c t i v a t e d i m m u n e cells. (Abstract# G4627) J Brokenshire, F Botelho, CD Richards and DM McKay. Hamilton, Canada A c t i v a t i o n of m i t o g e n - a c t i v a t e d p r o t e i n k i n a s e s u b g r o u p s a n d t r a n s c r i p t i o n factor i n gastric epithelial cells b y i n t e r l e u k i n . l ~ . (Abstract# G4604) T Arakawa, M Tsuno, K Tominaga, T Watanabe, Y Fujiwara, O Takaishi, T Fukuda, K Higuchi, SKim, K Yamasaki, H Iwa0, K Kobayashi and T Kuroki. Osaka, Japan Calmodulin-dependentprotein kinase and diacylglycerol-activated p r o t e i n k i n a s e C are i n v o l v e d i n c h o l e c y s t o k i n i n s e c r e t i o n b y p h e n y l a l a n i n e i n STC-1 cells. (Abstract# G4880) H Yoshida, M Iida, J Niikawa, S Tanaka and K Mitamura. Tokyo, Japan

E x p r e s s i o n a n d t r a n s l o c a t i o n of p r o t e i n k i n a s e C isoforms i n h u m a n a n t r a l G cells. (Abstract# G4770) E Moore and AMJ Buchan. Vancouver, Canada B o m b e s i n - i n d u c e d Ca 2+ oscillations do n o t m e d i a t e p e p t i d e secretion. (Abstract# G4714) KL Ives, V Udupi, GH Greeley, Jr, BN Christensen, CM Townsend, Jr and MR Hellmich. Galveston, TX TNFa i n d u c e d by H. pyloriphosphorylates JNK p a t h w a y w h i c h m a y i n d u c e apoptosis i n gastric mucosal cells. (Abstract# G4777) A Nagahara, H Miwa, M Hirose, H Misawa, M Kawabe, S Watanabe and N Sato. Tokyo, Japan Localization of Rab25 a n d R a b l l a i n e p i t h e l i a of the g a s t r o i n t e s t i n a l tract. (Abstract# G4787) K Nwokeji, J Smith and JR Goldenring. Augusta, GA Growth factors c o n t r o l apoptosis of r a t gastric enterochromaffin-like cells. (Abstract# G4752) S Mahr, N Neumayer, H Kolb, W Schepp and C Prinz. Munich, Germany Prostaglandins inhibit histamine and pancreastatin secretion from isolated r a t s t o m a c h ECL cells. (Abstract# G4747) E Lindstr6m and R H~kanson. Lund, Sweden ECL cell t r a n s p l a n t a t i o n i n rats. (Abstract# G4645) D Chen, C-M Zhao, E Lindstr6m, M Kitano, K Kimura and R H~ikanson. Lund, Sweden Vagally i n d u c e d gastric acid s e c r e t i o n d e p e n d s o n ECLcell h i s t a m i n e i n m a s t cell deficient b u t n o t i n wild-type mice. (Abstract# G4647) D Chen, K Andersson, C-M Zha0 and R H~kanson. Lund and M61ndal, Sweden SR146131: a new, p o t e n t , n o n - p e p t i d e o r a l l y active CCKA r e c e p t o r agonist. (Abstract# G4621) E Bign0n, R B0igegraln, M Cottineau, C Petereau, MP Rockstroh, E Seban, O Servant, M Pascal, JF Maffrand and G Le Fur. Toulouse, France Bioactivity a n d the m e c h a n i s m of i n h i b i t o r y action of C - t e r m i n a l l y e x t e n d e d forms of s e c r e t i n o n gastric acid secretion i n a n e s t h e t i z e d rats. (Abstract# G4828) YW Shin, TE Solomon and JH Walsh. Sunguam, Korea and Los Angeles, CA R e g u l a t i o n of a n t r a l a n d f u n d i c s o m a t o s t a t i n by g a s t r i n - r e l e a s i n g p e p t i d e a n d b e t h a n e c h o l . (Abstract# G4885) Y Zavros, WR Fleming, KJ Hardy and A Shulkes. Melbourne, Australia Effects of p r o t e i n o n gastric i n h i b i t o r y p o l y p e p t i d e e x p r e s s i o n i n the rat. (Abstract# G4688) KD Glazier, K-B Zha0, LA Jarboe, C-C Tseng and MM Wolfe. Boston, MA

I n h i b i t i o n of cell g r o w t h b y CCK r e q u i r e s a c t i v a t i o n of cyclic AMP s i g n a l i n g i n HEK-293 cells. (Abstract# G4872) SV Wu, M Yang, D Avedian and JH Walsh. Los Angeles, CA

Carboxypeptidease E deficiency i n mice w i t h the fat m u t a t i o n have r e d u c e d s t o m a c h f u n c t i o n . (Abstract# G4692) P Gomez, L Hallberg and GH Greeley, Jr. Galveston, TX

A c t i v a t i o n of the s m a l l GTP b i n d i n g p r o t e i n Rho A following CCK a n d c a r b a c h o l s t i m u l a t i o n of p a n c r e a t i c acini. (Abstract# G4784) F Nozu, Y Tsunoda and C Owyang. Ann Arbor, MI

Glucagon-like p e p t i d e II is t r o p h i c to the i n t e s t i n a l e p i t h e l i u m of i n t r a v e n o u s l y a n d orally fed rats. (Abstract# G4695) RA Goodlad, MA Ghatei, N Mandir, AE Brynes, M Jordinson, NA Wright and SR Bloom. London, United Kingdom

A c e t y l c h o l i n e - i n d u c e d c a l c i u m s i g n a l l i n g along t h e h u m a n colonic crypt-axis. (Abstract# G4746) SM Lindqvist, PA Sharp, IT Johnson, M Watson, M Rhodes and MR Williams. Norwich, United Kingdom

P46 PROGRAMOFTHEANNUALMEETING

GASTROENTEROLOGYVol.1141No.4

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II II

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POSTER

SESSION

M o d e l to s t u d y g a s t r i c a c i d s e c r e t i o n i n mice: effect of s e c r e t a g o g u e s a n d i n h i b i t o r s on b a s a l g a s t r i c a c i d s e c r e t i o n . (Abstract# G4845) B Torkian, V Mart~nez, JH Walsh and Y TachS. Los Angeles, CA H O R M O N E S , T R A N S M I T T E R S , G R O W T H FACTORS AND THEIR RECEPTORS -- RECEPTOR C H A R A C T E R I Z A T I O N AND R E G U L A T I O N

DDW Poster of Distinction: M o n i t o r p e p t i d e b i n d i n g s i t e s a r e e x p r e s s e d in l i v e r a n d s m a l l i n t e s t i n e . (Abstract# G4762) DC McVey, J Romac, W Clay, T Kost, RA Liddle and SR Vigna. Durham, NC E x p r e s s i o n of f u n c t i o n a l n a t r i u r e t i c p e p t i d e r e c e p t o r s i n r a t g a s t r i c m u c o s a l cells. (Abstract# G4631) JR Bundy, P Berry, Ae Shafii, KS Salhab, DL Vesely, PJ Fabri, H Matsui and WR Gower, Jr. Tampa, FL P u r i f i c a t i o n of t h e z o n u l a o c c l u d e n s t o x i n h u m a n r e c e p t o r . (Abstract# G4750) R Lu, R Vigorito, S Wisniewski, HR Zieike, W Wang and A Fasano. Baltimore, MD D e m o n s t r a t i o n of s e c r e t i n r e c e p t o r p h o s p h o r y l a t i o n u s i n g a s e n s i t i v e a n d specific r e c e p t o r a n t i s e r a . (Abstract# G4825) MA Shetzline, SR Vigna, MG Caron and RT Premont. Durham, NC Antisense oligonucleotide suppression of expression of VIP receptors in diverse intestinal cells. (Abstract# G4874) J Xue, F Christofi, CY Liu, EJ Goetzl, Y-Z Wang and HJ Cooke. Columbus, OH and San Francisco, CA The c a r b o x y l t e r m i n u s of t h e p i t u i t a r y a d e n y l a t e c y c l a s e a c t i v i t i n g p o l y p e p t i d e r e c e p t o r is c r i t i c a l for s i g n a l t r a n s d u c t i o n a n d i n t e r n a l i z a t i o n , (Abstract# G4751) RM Lyu and JR Pisegna. Los Angeles, CA S t r u c t u r e of t h e gene e n c o d i n g t h e r e c e p t o r for r a t g a s t r i c i n h i b i t o r y p o l y p e p t i d e . (Abstract# G4626) MO Boylan, LI Jepeal and MM Wolfe. Boston, MA I n t e r n a l i z a t i o n a n d r e c y c l i n g of galanin-1 r e c e p t o r s b y c l a t h r i n - m e d i a t e d p a t h w a y . (Abstract# G4870) H Wong, L Slice, N Zeng and JH Walsh. Los Angeles, CA The c y s t e i n e of t h e c y t o p l a s m i c t a i l of glucosedependent insulinotropic polypeptide receptor m e d i a t e s its c h r o n i c d e s e n s i t i z a t i o n a n d d o w n r e g u l a t i o n . (Abstract# G4846) C-C Tseng and X-Y Zhang. Boston, MA Gastric inhibitory polypeptide receptors are present a n d f u n c t i o n a l i n fat cells. (Abstract# G4877) RGC Yip and MM Wolfe. Boston, MA Role of t h e C - t e r m i n a l t r i p e p t i d e of xenin, WIL, i n t h e i n t e r a c t i o n of x e n i n w i t h t h e n e u r o t e n s i n r e c e p t o r c o n t r a c t i l i t y a n d b i n d i n g s t u d i e s . (Abstract# G4672) GE Feurle and G Hamscher. Hannover and Bonn, Germany The bombesin r e c e p t o r subtype 4 is coupled to phospholipase C a n d h a s a unique pharmacology. (Abstract# G4798) TK Pradhan, T Katsuno, RR Ryan, SA Mantey, MA Akeson, PJ Donohue, JF Battey, ER Spindel and RT Jensen. Bethesda, MD and Beaverton, OR

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MAY

17, 1998

II i[

Genomic c l o n i n g a n d c h a r a c t e r i z a t i o n of t h e h u m a n g a s t r i n - r e l e a s i n g p e p t i d e r e c e p t o r gene. (Abstract# G4867) HC Weber. Boston, MA Native human bombesin receptor subtype 3 has a u n i q u e p h a r m a c o l o g y . (Abstract# G4754) SA Mantey, RR Ryan, HC Weber, T Pradhan, DH Coy and RT Jensen. Bethesda, MD and New Orleans, LA S o m a t o s t a t i n r e c e p t o r s u b t y p e 5 m e d i a t e s i n h i b i t i o n of p e p t i d e YY s e c r e t i o n from i n t e s t i n a l c u l t u r e s . (Abstract# G4648) C Chisolm and GR Greenberg. Toronto, Canada Somatostatin r e c e p t o r type 2.mediated suppression of HeHcobacterpylorlproliferation in vltr~ (Abstract# G4875) K Yamashita, H Kaneko, T Konagaya, S Yamamoto, K Kusugami and T Mitsuma. Aichi and Nagoya, Japan Somatostatin receptor subtypes 1 and 2 couple d i f f e r e n t i a l l y to a d e n y l c y c l a s e s a n d to v o l t a g e - g a t e d c a l c i u m c h a n n e l s i n p a n c r e a t i c R I N 1046-38 cells. (Abstract# G4818) H Scherfibl, D Roosterman, G Glassmeier, H Baumeister, EO Riecken and W Meyerhof. Berlin and Potsdam, Germany GRK2 a n d GRK6 a r e i n v o l v e d i n h i s t a m i n e H2 r e c e p t o r d e s e n s i t i z a t i o n . (Abstract# G4678) Y Fukushima, T Saitoh, N Matsuhashi, Y Yazaki and K Sugano. Tokyo, Japan E x p r e s s i o n of f u n c t i o n a l GABAA r e c e p t o r s i n i s o l a t e d h u m a n i n s u l i n o m a cells. (Abstract# G4687) G Glassmeier, M H6pfner, H Buhr, S Niedrig, E-O Riecken, H Stein, H-J Quabbe, C Rancso, B Wiedenmann and H ScherObl. Berlin, Germany C o n s t a n t e x p r e s s i o n of IGF-I r e c e p t o r a n d v a r i a b l e effects of IGF-I d u r i n g c u l t u r e o f i n t e s t i n a l s m o o t h m u s c l e cells. (Abstract# G4733) JF Kuemmerle. Richmond, VA T e l e n z e p i n e defines t h e d i f f e r e n t i a l r o l e of p a r i e t a l a n d e n t e r o c h r o m a f f i n - l i k e cell m u s c a r i n i c r e c e p t o r s in g a s t r i c s e c r e t o r y functions. (Abstract# G4821) S Schmid, T Zhang, LH Tang and IM Modlin. New Haven, CT GRG/AGA Spring Symposium 2:00-5:00 p m Room 99 Ernest N. Morial Convention Center

Course Directors: Hannah Carey, Kim E. Barrett W A T E R AND SOLUTE T R A N S P O R T ACROSS INTESTINAL EPITHELIA: EMERGING M E C H A N I S M S AND C U R R E N T C O N T R O V E R S I E S 2:00

W a t e r t r a n s p o r t of Na+-coupled t r a n s p o r t e r s . Ernest M. Wright. Los Angeles, CA

2:45

A q u a p o r i n s in GI a n d o t h e r e p i t h e l i a ? Dennis Brown. Boston, MA

3:30

C o n t r i b u t i o n of t h e t r a n s c e l l u l a r p a t h w a y to glucose t r a n s p o r t i n i n t e s t i n a l e p i t h e l i a . Robert E. Kimura. Chicago, IL

4:15

T i g h t j u n c t i o n b a r r i e r f u n c t i o n in p h y s i o l o g i c a n d p a t h o l o g i c states. James L. Madara. Atlanta, GA

pri11998

PROGRAM OF T H E ANNUAL M E E T I N G P4'

SUNDAY, MAY 17, 1998 State of the Art Lecture

2:15-3:15 p m

3:15

A l t e r a t i o n s i n h i s t a m i n e s y n t h e s i s i n ECL cells from CCK-B/gastrin r e c e p t o r d e f i c i e n t mice are reflected both by enzymatic and m o r p h o l o g i c a b n o r m a l i t i e s . (Abstract# G4644) D Chen, C-M Zhao, W A1-Haider, R H~kanson and AS Kopin. Lund, Sweden and Boston, MA

3:30

Reg protein production by rat e n t e r o c h r o m a f f i n - l i k e cells is a p o s s i b l e l i n k between hypergastrinemia and gastric m u c o s a l p r o l i f e r a t i o n . (Abstract# G4677) H Fukui, Y Kinoshita, T Maekawa, A Okada, MS Hassan, S Waki, H Okamoto and T Chiba. Kyoto, Izumo and Sendal, Japan

Room 9 0 / 9 1 / 9 2 Ernest N. Morial Convention Center

Sponsored by Motility and Nerve-Gut Interactions I n t e s t i n a l gas r e v i s i t e d . Juan R. Malagelada. Barcelona, Spain AGA CHnical Symposium

2:15-3:45 p m

Room 58/59 / 60 Ernest N. Morial Convention Center

S p o n s o r e d b y Clinical P r a c t i c e Co-sponsored by Growth, Development, Nutrition and I m m u n o l o g y , Microbiology, a n d I n f l a m m a t o r y Disorders

Chair:

Craig J. McClain

CONTEMPORARY ISSUES IN NUTRITION T h e e x p a n d i n g r o l e of e n t e r a l feeding: p a t i e n t assessment and clinical applications. Craig J. McClain. Lexington, KY

AASLD Research Forum

2:15-3:45 p m

Chairs: Paul Martin, K. Rajender Reddy T R E A T M E N T O F VIRAL H E P A T I T I S 2:15

A m u l t i c e n t e r , r a n d o m i z e d t r i a l of daily, h i g h dose interferon-cL2b for t h e t r e a t m e n t of c h r o n i c h e p a t i t i s C: p r o s p e c t i v e s t r a t i f i c a t i o n b y v i r a l b u r d e n a n d g e n o t y p e . (Abstract# L0180) MW Fried, ML Shiffman, RK Sterling, J Weinstein, J Crippin, G Garcia, TL Wright, H Conjeevaram, RK Reddy, J Peter, G Cotsonis and FS Nolte. Richmond, VA; Cleveland, OH; Houston, TX; Atlanta, GA; San Francisco and Stanford, CA; Miami, FL and Chicago, IL.

2:30

Interleukin-12 therapy in patients with c h r o n i c h e p a t i t i s C. (Abstract# L0638) G Teuber, T Berg, S R~dig, WF Caspary, U Hopf and S Zeuzem. Frankfurt and Berlin, Germany

2:45

R e c o m b i n a n t i n t e r f e r o n t h e r a p y for c h r o n i c h e p a t i t i s C i n p a t i e n t s w i t h HIV infection. (Abstract# L0043) C Bartholomew, PJ Piliero, S Szebenyi, B McKenna, B Stellrecht and C Ramnes. Albany, NY

3:00

D e t r i m e n t a l i n f l u e n c e of HIV on t h e n a t u r a l history and the interferon response rate in p a t i e n t s w i t h c h r o n i c h e p a t i t i s B. (Abstract# L0640) T Thevenot, V Di Martino, J F Colin, F Degos, S Erlinger, JP Benhamou and P Marcellin. Clichy, France

3:15

Dual effects of h e p a t i t i s B i n f e c t i o n a n d hepatitis B immunoglobulin in reducing the i n c i d e n c e of a c u t e r e j e c t i o n p o s t t r a n s p l a n t a t i o n . (Abstract# L0507) MG Pessoa, E Kim, P Martin, J Crippin, E Keeffe, R Gish, N Ascher, TL Wright and NA Terrault. San Francisco, Los Angeles and Stanford, CA, Houston, TX

3:30

I n t e r f e r o n - a a n d r i b a v i r i n i n e s t a b l i s h e d postliver transplant recurrent hepatitis C infection. (Abstract# L0289) A Kapur, MJ Rodriguez, S Schecter, AG Tzakis and ER Schiff. Miami, FL

N u t r i t i o n s u p p o r t i n l i v e r disease. Arthur J. McCullogh. Cleveland, OH N u t r i t i o n i n i n f l a m m a t o r y b o w e l disease. Samuel T. Klein. St. Louis, MO S u p p l e m e n t a t i o n a n d s u p p o r t of t h e AIDS p a t i e n t . Donald P. Kottler. New York, NY Questions and Answers. AGA Topic Forum

2:15-3:45 p m

Room 80/81 Ernest N. Morial Convention Center

Chairs: George Sachs, Alan Kopin ECL CELLS: R E C E P T O R S AND F U N C T I O N 2:15

Different histamine pools in rat gastric e n t e r o c h r o m a f f i n - l i k e cells. (Abstract# G1076) C Prinz, R Zanner, A GaUer, M Classen, B H6hneZell and M Gratzl. Munich, Germany

2:30

E n t e r o c h r o m a f f i n - l i k e cell f u n c t i o n i n t r a n s g e n i c m i c e e x p r e s s i n g g a s t r i n in p a n c r e a t i c ~-cells. (Abstract# G46U) GW Bate, A Varro, R Dimaline, TC Wang, TJ Koh and GJ Dockray. Liverpool, United Kingdom and Boston, MA

2:45

Pituitary adenylate cyclase-activating peptide m o d u l a t e s g a s t r i c e n t e r o c h r o m a f f i n - l i k e cell p r o l i f e r a t i o n i n r a t s . (Abstract# G4738) JM L~iuffer, IM Modlin, M Kidd, T Zhang, SW Schmid and LH Tang. New Haven, CT

3:00

I d e n t i f i c a t i o i n o f g a s t r i c e n d o c r i n e cells as t h e t a r g e t sites of n e u r o p e p t i d e s in r e g u l a t i o n of g a s t r i c s e c r e t i o n b y s e m i - q u a n t i t a t i v e RT-PCR a n d v i d e o i m a g i n g . (Abstract# G4887) N Zeng, T Kang, C Athmann, Y Wen, JH Walsh and G Sachs. Los Angeles, CA

Ballroom C Ernest N. Morial Convention Center

P48 PROGRAMOFTHEANNUALMEETING

AASLD Research Forum

2:15-3:45 p m

GASTROENTEROLOGYVol.1141No. 4

2:45

Association of multispecific CD4+ r e s p o n s e to h e p a t i t i s C a n d severity of r e c u r r e n c e after liver t r a n s p l a n t a t i o n . (Abstract# L0536) HR Rosen, M Blake, M Houghton, DJ Hinrichs, S Chou, DR Gretch and HA Bouwer. Portland, OR; Emeryvlile, CA and Seattle, WA

3:00

I m p a i r e d ATP synthesis m a y e x p l a i n fatty liver s u s c e p t i b i l i t y to p r i m a r y n o n f u n c t i o n . (Abstract# L0103) K Chavin, J Chatham, VP Chako, SQ Yang, HZ Lin and AM Diehl. Baltimore, MD

3:15

I m m u n o m o d u l a t o r y effects of Kupffer cells o n antigen-stimulated T lymphocyte proliferation in vitro. (Abstract# L0615) ZL Sun, K Maemura, N Sakamoto, M Ozaki, GB Bulkley and AS Klein. Baltimore, MD

3:30

Novel b a c t e r i o c h l o r i n e for h i g h tissue p e n e t r a t i o n - p h o t o d y n a m i c effect o n b i l i a r y t r a c t c a n c e r cells. (Abstract# L0477) M Oertel, F Berr, J MSssner, R Hermann, AM Shulga and SI Schastak. Leipzig, Germany and Minsk, Russia

Room 93 / 94 Ernest N. Morial Convention Center

Chairs: Mark J. Czaja, Kyle Brown LIVER I N J U R Y AND F I B R O S I S 2:15

2:30

Cytoskeletal i n t e r m e d i a t e f i l a m e n t p r o t e i n phosphorylation provides a protective physiologic role a g a i n s t liver i n j u r y . (Abstract# L0339) N-O Ku, SA Michie, EZ Resurreccion and MB Omary. Palo Alto, CA Different roles of free hydroxl radicals, n i t r i c oxide a n d t u m o r n e c r o s i s factor-a i n t h i o a c e t a m i d e i n d u c e d liver cirrhosis i n rats. (Abstract# L0075) R Bruck, H Shirin, H Aeed, L Zaidel and Y Avni. Holon and Tel-Aviv, Israel

2:45

A c e t a m i n o p h e n hepatotoxicity: n e w insights. (Abstract# L0143) R Devalarja, S Barve, D Hill and C McClain. Lexington, KY

3:00

The e t h a n o l metabolites, f a t t y acid ethyl esters, a c t i v a t e r a t h e p a t i c stellate cells. (Abstract# L0373) JJ Li, R O'Neill, S Chen, PS Bora, RS Britton and BR Bacon. St Louis, MO

4:00-5:30 p m

a 5 a n d ~1 i n t e g r i n s u b u n i t expression i n h e p a t i c stellate cells is r e g u l a t e d b y e x t r a c e l l u l a r m a t r i x p r o t e i n s . (Abstract# L0020) MA Anbari, JE Poulos, MT MiUiano and BA Luxon. St Louis, MO

Chair: Kevin W. Olden

3:15

3:30

I n h i b i t i o n of p r o i n f l a m m a t o r y molecule e x p r e s s i o n b y a d e n o v i r u s - m e d i a t e d expression of a n NF~B s u p e r r e p r e s s o r i n activated h e p a t i c stellate cells. (Abstract# L0228) C Hellerbrand, C Jobin, Y Limuro, LL Licato, RB Sartor and DA Brenner. Regensburg, Germany and Chapel Hill, NC

AASLD Research Forum

2:15-3:45 p m

Room 95 / 96 Ernest N. Morial Convention Center

Chairs: John M. Vierling, Santiago Munoz

AGA CHnical Symposium

Room 58 / 59 / 60 Ernest N. Moria[ Convention Center

Sponsored b y Clinical P r a c t i c e Co-sponsored by Motility a n d Nerve-Gut I n t e r a c t i o n s

MULTIDISCIPLINARY APPROACH TO CHRONIC ABDOMINAL PAIN I n t r o d u c t i o n : Who m a y benefit? Kevin W. Olden. San Francisco, CA Why should psychotropies help GI p a i n : lessons from the c h r o n i c p a i n l i t e r a t u r e . Anthony J. Lembo. Boston, MA Do they work a n d how? Lessons for GI l i t e r a t u r e . Ray Clouse. St. Louis, MO Maximizing P a t i e n t Acceptance for P s y c h o t r o p i c Drugs. Martin D. Gelfand. Seattle, WA Cogltive a n d g r o u p t h e r a p y : What t e c h n i q u e s for w h a t p a t i e n t s , a n d for how long?. Kevin W. Olden. San Francisco, CA

LIVER T R A N S P L A N T A T I O N I Questions and Answers. 2:15

H e p a t o e y t e t r a n s p l a n t a t i o n r e p o p u l a t e s the liver a n d i n c r e a s e s s u r v i v a l after p a r t i a l h e p a t e c t o m y a n d whole liver i r r a d i a t i o n i n F344 rats. (Abstract# L0211) C Guha, B Vikram, S Gupta, A Sharma, A Alfieri, S Gagandeep, RP Sokhi, GR Gorla, KE Tanaka and JR Chowdhury. New York, NY

2:30

The role of T cell p h e n o t y p i n g d u r i n g i m m u n o s u p p r e s s i o n w i t h d r a w a l i n liver t r a n s p l a n t a t i o n . (Abstract# L0411) M McCarthy, P Norman, J Devlin, T Wong, R Vaughan, P Gibbs, P Donaldson and R Williams. London, United Kingdom

April 1998

PROGRAM OF THE ANNUAL MEETING P49

SUNDAY, MAY 17, 1998 AGA C l i n i c a l S y m p o s i u m 4:00-5:30 p m Room 97/98 Ernest N. Morial Convention Center

AGA R e s e a r c h S y m p o s i u m 4:00-5:30 p m Room 80 / 81 Ernest N. Morial Convention Center

Sponsored by Growth, Development, Nutrition C o - s p o n s o r e d b y N a t i o n a l I n s t i t u t e s of H e a l t h

Sponsored by Growth, Development, Nutrition Co-sponsored by Intestinal Disorders and Immunology, Microbiology, a n d I n f l a m m a t o r y D i s o r d e r s

Chairs: Henry Francis, Frank A. Hamilton

Chair: M E T A B O L I C , E N D O C R I N E A N D GASTROI N T E S T I N A L D I S O R D E R S I N D R U G U S E AND HIV/AIDS Overview: P r o g r a m of t h e NIDA. Jag H. Khalsa. Rockville, MD Nutrition and immunology. Ranjit Chandra. St. John's, Canada GI/metobolic/endocrine disorders in drug users with HIV/AIDS. Sherwood L. Gorbach. Boston, MA

Daniel K. Podolsky

W O U N D H E A L I N G / R E S T I T U T I O N AND R E P A I R Overview. Daniel K. P0dolsky. Boston, MA Regulatory peptides and healing. Axel U. Dignass. Essen, Germany Extracellular matrix and wound healing. M. Pignatelli. London, England M e c h a n i s m s of cell m i g r a t i o n i n h e a l i n g . Asma Nusrat. Boston, MA

Role o f n u t r i e n t s in HIV/AIDS d i s e a s e p r o g r e s s i o n a m o n g d r u g users. Marianna K. Baum. Miami, FL

AGA T o p i c F o r u m 4:00-5:30 p m

M o l e c u l a r b a s i s of n u t r i e n t s i n HIV d i s e a s e p r o g r e s s i o n a m o n g d r u g users. Ethan Will Taylor. Athens, GA

Chairs: William J. Sandborn, Geert D'Haens

AGA C l i n i c a l S y m p o s i u m 4:00-5:30 p m Room 90 / 91 / 92 Ernest N. Morial Convention Center

C L I N I C A L P H A R M A C O L O G Y O F IBD T H E R A P Y 4:00

A r a n d o m i z e d , single-blind, p h a r m a c o k i n e t i c a n d d o s e - r e s p o n s e s t u d y of s u b c u t a n e o u s m e t h o t r e x a t e , 15 a n d 25 mg/week, for r e f r a c t o r y u l c e r a t i v e colitis a n d Crohn's disease. (Abstract# G3978) LJ Egan, WJ Sandborn, WJ Tremaine, JA Leighton, DC Mays, MG Pike, AR Zinsmeister and J J Lipsky. Rochester, MN and Scottsdale, AZ

4:15

B u d e s o n i d e v e r s u s p r e d n i s o n e in t h e t r e a t m e n t of active C r o h n ' s disease: a doubleb l i n d c o n t r o l l e d trial. (Abstract# G3797) S Bar-Meir. Tel Hashomer, Israel

4:30

Dose r a i s i n g of a z a t h i o p r i n e b e y o n d 2.5 mg/kg/day i n Crohn's d i s e a s e p a t i e n t s w h o fail to i m p r o v e w i t h a s t a n d a r d dose. (Abstract# G3794) L Barbe, P Marteau, M L6mann, Y Bouhnik, M Allez, B Coffin, J Bonnet, B Messing, JC Rambaud and R Modigliani. Paris, France

4:45

R e l e a s e c h a r a c t e r i s t i c s of b u d e s o n i d e f r o m pHm o d i f i e d r e l e a s e c a p s u l e s a n d c o n t r o l l e d ileal r e l e a s e capsules. (Abstract# G4263) HW MSllmann, M Wagner, A Tromm, AC MSllmann, S Homrighausen, J Barth, M Krieg and G Hochhaus. Bochum, Germany and Gainesville, FL

5:00

Oleic a c i d i m p r o v e s d r u g a b s o r p t i o n i n p a t i e n t s w i t h i n f l a m m a t o r y bowel disease. (Abstract# G4521) G Van Citters and HC Lin. Los Angeles, CA

5:15

Oral l i p o s o m e s as a d r u g d e l i v e r y s y s t e m for t h e t r e a t m e n t of i n f l a m m a t o r y b o w e l disease. (Abstract# G4599) SY Zh0u, D Fleisher, N Weiner and EM Zimmermann. Ann Arbor, MI

Sponsored by Motility and Nerve-Gut Interactions Co-sponsored by Intestinal Disorders and Growth, Development, Nutrition and Hormones, Transmitters, Growth Factors, and their Receptors

Chairs: Chung Owyang, Michael Camilleri GI C O M P L I C A T I O N S O F D I A B E T E S M E L L I T U S 4:00

E p i d e m i o l o g y of g a s t r o i n t e s t i n a l c o m p l i c a t i o n s of d i a b e t e s in a U.S. C o m m u n i t y G: Richard Locke, III. Rochester, MN

4:15

D i a b e t i c d y s p e p s i a : m e c h a n i s m effect of hyperglycemia on motor function and management. William L. Hasler. Ann Arbor, MI

4:35

C o n s t i p a t i o n a n d a n o r e e t a l dysfunction. William Chey, Jr. Ann Arbor, M!

4:45

M a n a g e m e n t of d i a r r h e a in p a t i e n t s w i t h d i a b e t e s mellitus. Lawrence R. Schiller. Dallas, TX

5:00

P a t h o g e n e s i s of n e u r o p a t h y affecting t h e GI tract. John W. Wiley. Ann Arbor, MI

5:15

Room 64 / 65 / 66 Ernest N. Morial Convention Center

Discussion.

GASTROENTEROLOGY Vol. 114~No. 4

p50 PROGRAM OF THE ANNUAL MEETING

II

SUNDAY, MAY 17, 1998

AASLD Research Forum

4:00-5:30 p m

4:45

The t r a n s f o r m i n g g r o w t h f a c t o r - ~ l - r e g u l a t e d t r a n s c r i p t i o n factor, TIEG, c o n t r i b u t e s to TGF~l-induced a p o p t o s i s of H e p 3B cells. (Abstract# L0529) A Ribeiro, PJ Roberts, SF Bronk, R Urrutia and GJ Gores. Rochester, MN

5:00

D o n o r p r e t r e a t m e n t w i t h IL-10 d e c r e a s e s TNF, IFN-T r e l e a s e a n d l i v e r i n j u r y a f t e r c o l d i s c h e m i a - r e p e r f u s i o n i n mice. (Abstract# L0365) 0 Le Moine, H Louis, E Quertinmont, S Narula, M Goldman and J Devi~re. Brussels, Belgium and New Jersey

5:15

E x p r e s s i o n of m a t r i x m e t a l l o p r o t e i n a s e s a n d t h e i r i n h i b i t o r s i n t h e liver: c e l l u l a r localization, r e g u l a t i o n b y c y t o k i n e s a n d t i m e kinetics during hepatic tissue repair. (Abstract# L0325) T Knittel, M Mehde, K Kobold, B Saile and G Ramadori. Goettingen, Germany

Room 85/86 Ernest N. Morial Convention Center

Chairs: T. Jake Liang, Maria Sjogren PATHOGENESIS AND NATURAL HISTORY OF HEPATITIS C 4:00

E v i d e n c e for a c o o r d i n a t e d CD4 a n d C D 8 i m m u n e r e s p o n s e i n c h r o n i c HCV a n d its i m p l i c a t i o n s o n p a t h o g e n e s i s . (Abstract# L0461) DR Nelson, B Bhardwaj, RP Gonzalez-Peralta, AT Isaacson and JYN Lau. Gainesvine, FL

4:15

H e p a t i c e x p r e s s i o n of i n t e r l e u k i n - 1 2 a l t e r s o u t c o m e i n HCV-infected p a t i e n t s . (Abstract# L0521) R Rai, F Anania, J Boitnott, AM Diehl, C Spoler and D Thomas. Baltimore, MD

4:30

Effect of d i e t a r y i r o n l o a d i n g i n c h i m p a n z e e s w i t h c h r o n i c h e p a t i t i s C v i r u s infection. (Abstract# L0145) AM Di Bisceglie, SE Bassett, BR Bacon and. RE Lanford. St Louis, MO and San Antonio, TX

4:45

5:00

5:15

W o r r i s o m e d i s p o s i t i o n of h e p a t i t i s C a n t i b o d y p o s i t i v e p a t i e n t s . (Abstract# L0553) SA Sarbah, P Kim, GN Levinthal, AJ McCullough and KD Mullen. Cleveland, OH Liver fibrosis progression in patients with h e p a t i t i s C, w i t h a n d w i t h o u t HIV infection. (Abstract# L0518) M Puoti, M Bonacini, S Govindarajan, A Spinetti, V Putzolu, M Favret and F Callea. Brescia, Italy and Los Angeles, CA The l o n g t e r m c l i n i c a l o u t c o m e s of p a t i e n t s with HCV-related compensated cirrhosis and h i s t o r y of p a r e n t e r a l e x p o s u r e . (Abstract# L0249) K-Q Hu and MJ Tong. Pasadena, CA

AASLD Research Forum

4:00-5:30 p m

Chairs: J. Eileen Hay, Todd K. Howard LIVER T R A N S P L A N T A T I O N II 4:00

New onset cardiomyopathy in adult liver t r a n s p l a n t r e c i p i e n t s on t a c r o l i m u s . (Abstract# L0651) R Umashanker, C Koo, T Sato, S Chopra, R Jenkins, WD Lewis and F Gordon. Boston, MA

4:15

T h r o m b o c y t o p e n i a following l i v e r t r a n s p l a n t a t i o n . (Abstract# L0102) MA Chatzipetrou, D Weppler, A Tsaroucha, G Iaria, F Lupo, NS Kenyon, C Ricordi and AG Tzakis. Miami, FL

4:30

Q u a l i t y of life a f t e r l i v e r t r a n s p l a n t a t i o n i n p a t i e n t s w i t h h e p a t i t i s C. (Abstract# L0199) JS Goff, RF Hamman, FS Wamboldt, GT Everson, R Shrestha, I Kam, M Wachs, DC Lezotte, T Steinberg, M Talamantes and BM Bflir. Denver, CO

4:45

L i v e r t r a n s p l a n t a t i o n for n o n a l c o h o l i c s t e a t o h e p a t i t i s . (Abstract# L0681) S Westen, MR Charlton and KD Lindor. Rochester, MN

AASLD Research Forum

4:00-5:30 p m

Room 93/94 Ernest IV. Morial Convention Center

Chairs: Jacquelyn J. Maher, Craig J. McClain

Room 95/96 Ernest N. Morial Convention Center

CYTOKINES AND ALCOHOL 4:00

R e c o m b i n a n t r a t LBP a c c e l e r a t e s L P S - i n d u c e d K u p f f e r cell a c t i v a t i o n . (Abstract# L0610) GL Su, RD Klein, SM Eddy and SC Wang. Ann Arbor, MI

5:00

R e c u r r e n c e of p r i m a r y b i l i a r y c i r r h o s i s a f t e r living related donor liver transplantation. (Abstract# L0254) T Ichida and M Omata, Tokyo, Japan

4:15

D e c r e a s e d a c t i v i t y of g a s t r i c class III(;0 ADH c a n e x p l a i n i n c r e a s e d b i o a v a i l a b i l i t y of alcohol i n women. (Abstract# L0038) E Baraona, K Dohmen, G Pozzato and CS Lieber. New York, NY and Trieste, Italy

5:15

4:30

A c u t e a l c o h o l r e g u l a t i o n of i n f l a m m a t o r y c y t o k i n e p r o d u c t i o n i n h u m a n monocytes: a r o l e for NF-KB. (Abstract# L0621) G Szabo, P Mandrekar and D Catalano. Worcester. MA

The use of n e w u l t r a s o u n d c o n t r a s t m e d i u m a f t e r o r t h o t o p i c l i v e r t r a n s p l a n t . (Abstract# L0235) C Herold, D Becket, F K6ckerling, M Wehler, D Tauschek, D Strobel, HT Schneider and EG Hahn. Erlangen-Nuremberg, Germany

April 1998

tl

PROGRAM OF THE ANNUAL MEETING P51

SUNDAY, MAY 17, 1998

Motility and Nerve-Gut Interactions AGA Research Forum 4:00-5:30 p m Room 82/83 Ernest N. Morial Convention Center

Chairs: William G. Paterson, Kenton M. Sanders I N T E R S T I T I A L C E L L S AND S M O O T H M U S C L E TYPES 4:00

C a l c i u m c u r r e n t s i n i n t e r s t i t i a l cells f r o m h u m a n j e j u n u m . (Abstract# G3392) A Rich, G Farrugia, MG Sarr and JH Szurszewski. Rochester, MN

4:15

R e l a t i o n s h i p of i n t e r s t i t i a l cells of Cajal w i t h n e r v e s in t h e m o u s e s m a l l i n t e s t i n e . S t u d i e s of Kit expression and neurochemical coding by confocal a n d e l e c t r o n m i c r o s c o p y . (Abstract# G3497) J-M Vanderwinden, JJ Rumessen, F Bernex and JJ Panthier. BrusseUes, Belgium; Hvidovre Denmark and Maisons-Alfort, France

Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum 4:00-5:30 p m Room 89 Ernest N. Morial Convention Center

Chair:

Phillip D. Smith, Lars Eckmann

P A T H O G E N E S I S O F GI AND H E P A T I C I N F E C T I O N S 4:00

Crffptosporidtum p a r t i t a i n f e c t i o n of b i l i a r y e p i t h e l i a o c c u r s v i a specific g l y c o p r o t e i n s on the apical cholangiocyte plasma membrane. (Abstract# G3898) X-M Chen, P Tietz, EWA Krueger, MA McNiven and NF LaRuss0. Rochester, MN

4:15

I n c r e a s e d n e u r o t e n s i n r e c e p t o r mRNA i n t h e colonic m u c o s a d u r i n g Clostriudlum dfftlcile p s e u d o m e m b r a n o u s colitis in h u m a n s . (Abstract# G4333) A Pasha, C Wang, S Nikulasson, C Pothoulakis and I Castagiiuolo. Boston, MA

4:30

A d e f i c i e n c y of i n t e r s t i t i a l cells of Cajal i n C h a g a s i c megacolon. (Abstract# G3128) R Hagger, C Finlayson, F Kahn, R De Oliveira, L Chimelli and D Kumar. London, United Kingdom and S~0 Paul0, Brazil

4:30

AP-2 a n d NF-KB r e g u l a t e ENA-78 gene e x p r e s s i o n i n Salmonella dublin i n f e c t e d CaCo-2 i n t e s t i n a l e p i t h e l i a l cells. (Abstract# G4122) AC Keates, S Keates and CP Kelly. Boston, MA

4:45

N e u r o n a l a n d e n d o t h e l i a l n i t r i c oxide s y n t h a s e s w e r e n o t d e t e c t e d i n c-Kit-positive i n t e r s t i t i a l cells of C a j a l in a d u l t h u m a n s t o m a c h a n d i n t e s t i n e . (Abstract# G3144) C He, SM Miller, MG Sarr, JH Pembert0n, G Farrugia and JH Szurszewski. Rochester, MN

4:45

A s o l u b l e f a c t o r f r o m Helicobacterpylo~ i n d u c e s e x p r e s s i o n a n d a c t i v i t y of cyclooxygenase-2. (Abstract# G4528) RV Varanasi, KS Ramanujam and KT Wilson. Baltimore, MD

5:00 5:00

I n t e r s t i t i a l cells of Cajal a n d n e r v e s i n m o u s e colon. S t u d i e s of K i t e x p r e s s i o n a n d n e u r o c h e m i c a l c o d i n g b y confocal a n d e l e c t r o n m i c r o s c o p y . (Abstract# G3496) J-M Vanderwinden, J J Rumessen, F Bernex and JJ Panthier. Brusselles, Belgium; Hvidovre, Denmark and Maisons-Alfort, France

D i f f e r e n t i a l h e p a t i c i n f l a m m a t i o n i n AXB r e c o m b i n a n t i n b r e d m i c e in s t r a i n s i n o c u l a t e d w i t h Helicobacter hepaticus. (Abstract# G4098) M Ihrig, M Schrenzel and JG Fox. Cambridge, MA

5:15

Staphylococcal enterotoxin B induces different m e c h a n i s m s of l y t i c a c t i v i t y b y j e j u n a l i n t r a e p i t h e l i a l l y m p h o c y t e s . (Abstract# G4378) AI Roberts, R Blumberg and EC Ebert. New Brunswick, NJ and Boston, MA

5:15

Rho A regulates sustained smooth muscle contraction through cytoskeletal r e o r g a n i z a t i o n of t h e a c t i n b i n d i n g p r o t e i n Hsp27. (Abstract# G3520) P Wang and KN Bitar. Ann Arbor, MI

P52 PROGRAM O F T H E A N N U A L M E E T I N G

G A S T R O E N T E R O L O G Y Vol. 114~ No. 4

SUNDAY, MAY 17, 1998 AASLD Poster Discussion

5:30-6:30 p m

Room 58 / 59 / 60 Ernest N. Morial Convention Center

Moderator: Adrian Di Bisceglie Presenter: Robert G. Gish, M.D. T R E A T M E N T OF H E P A T I T I S C

ABSTRACTS TOBE DISCUSSED:

I n s u l i n - d e p e n d e n t d i a b e t e s m e l l i t u s d u e to i n t e r f e r o n a2a t h e r a p y for c h r o n i c v i r a l h e p a t i t i s C. (Abstract# L0192) M Gatzen, BJ Manfras, U Wiest, W Richter, C LSliger, P Kiihnl, P vanEndert, J Pausch and BO Boehm. Kassel, Ulm and Hamburg, Germany; Paris, France Quality of life i n p a t i e n t s w i t h c h r o n i c h e p a t i t i s C d u r i n g h i g h dose i n d u c t i o n i n t e r f e r o n t r e a t m e n t . (Abstract# L0093) JW Cha, TJ Layden and NP Lam. Chicago, IL

A m u l t i c e n t e r , r a n d o m i z e d t r i a l of daily, high dose interferon-~2b for the t r e a t m e n t of c h r o n i c h e p a t i t i s C: prospective stratification by viral b u r d e n and genotype. (Abstract# L0180) MW Fried. Atlanta, GA

High-dose i n d u c t i o n w i t h i n t e r f e r o n - a 2 b is safe a n d efficacious i n i n t e r f e r o n r e l a p s e r s a n d n o n - r e s p o n d e r s with c h r o n i c h e p a t i t i s C. (Abstract# L0188) D Ganger, H Conjeevaram, T Wiley, S Flamm and K O'Riordan. Chicago, IL

S u s t a i n e d r e s p o n s e r a t e s of c h r o n i c h e p a t i t i s C p a t i e n t s t r e a t e d w i t h i n t e r f e r o n a l p h a w i t h doses t a i l o r e d to p r e - t r e a t m e n t HCV RNA levels: a prospective r a n d o m i z e d pilot study. (Abstract# L0177) BL Freilich, JB Eisenach, J Raines, L Jackson, T VanOmmeren and K Cornish. Kansas City, MO

Effect of i n i t i a l i n t e r f e r o n d o s i n g a n d dose o n early r e s p o n s e to c o m b i n a t i o n t h e r a p y w i t h r i b a v i r i n i n c h r o n i c h e p a t i t i s C. (Abstract# L0169) P Ferenci, P Steindl, C Datz, W Lin and W Vogel. Vienna and Innsbruck, Austria

Daily high-dose i n t e r f e r o n s u p p r e s s e s v i r e m i a i n p a t i e n t s w i t h c h r o n i c h e p a t i t i s C w i t h o u t a previous s u s t a i n e d r e s p o n s e to s t a n d a r d t r e a t m e n t . (Abstract# L0206) JB Gross, DJ Brandhagen, JJ Poterucha, AA G0ssard, DD Douglas and the Midwest Hepatitis Study Group. Rochester, MN S e q u e n t i a l v e r s u s c o n c o m i t a n t a d m i n i s t r a t i o n of r i b a v i r i n a n d i n t e r f e r o n - a n 3 i n p a t i e n t s with c h r o n i c h e p a t i t i s C n o t r e s p o n d i n g to i n t e r f e r o n alone. Results of a r a n d o m i z e d c o n t r o l l e d trial. (Abstract# L0600) R Sostegni, V Ghisetti, F Pittaluga, G Marchiaro, G Rocca, E Borghesio, M Rizzetto and G Saracco. Turin, Italy

Sustained alanineaminotransferasenormalization r e g a r d l e s s of v i r u s e r a d i c a t i o n is associated w i t h longl a s t i n g histologic i m p r o v e m e n t i n c h r o n i c h e p a t i t i s C p a t i e n t s t r e a t e d w i t h interferon-a. (Abstract# L0076) S Bruno, A Manzin, G Bellati, A Crosignani, M Maggioni, L Solforosi, S Rossi, MO Pedicino, M Clementi, G Id~o and M Podda. Milan, Italy S u s t a i n e d virologic r e s p o n s e to i n t e r f e r o n - a i n c h r o n i c h e p a t i t i s C is associated w i t h long t e r m histologic i m p r o v e m e n t a n d lack of h e p a t i c HCV RNA. (Abstract# L0353) DT-Y Lau, DE Kleiner, MG Ghany, P Schmid and JH Hoofnagle. Bethesda, MD and Los Angeles, CA DDW

Trainee Symposium

High dose i n d u c t i o n t h e r a p y w i t h a l p h a i n t e r f e r o n is effective i n p a t i e n t s w i t h h i g h h e p a t i t i s C viral load. (Abstract# L0201) HJ Gonzalez, SB Ho, JB Gross, C Peine, D McKee, T Smith and the Midwest Hepatitis Study Group. Minneapolis, MN

5:30-7:00 p m

Biphasic v i r a l c l e a r a n c e of HCV genotype I d u r i n g h i g h dose IFN i n d u c t i o n t r e a t m e n t . (Abstract# L0346) NP Lam, AU Neumann, AS Perelson, DR Gretch, TE Wiley and TJ Layden. Chicago, IL; Israel; Los Alamos, NM and Seattle, WA

Chairs: Ann Ouyang, Partha Nandi

Differences i n v i r a l k i n e t i c s b e t w e e n HCV genotype 1 v e r s u s 2 or 3 m a y e x p l a i n differences i n t r e a t m e n t response. (Abstract# L0347) NP Lain, AU Neumann, AS Perelson, DR Gretch, TE Wiley and TJ Layden. Chicago, IL; Israel; Los Alamos, NM and Seattle, WA R e d u c e d s e n s i t i v i t y of HCV g e n o t y p e 3 to a i n t e r f e r o n 2b (INTRON A) w h e n co-infected w i t h genotype 1. (Abstract# L0471) DP Nunes, GD Offner and NH Afdhal. Boston, MA

Room Oak Alley New Orleans Hilton Riverside Hotel

Co-sponsored by M a n p o w e r a n d T r a i n i n g Committee, T r a i n e e Committee

HOW TO GET A JOB IN ACADEMIA OR CLINICAL PRACTICE Introduction. Phillip P. Toskes. Gainesville, FL How to get a job i n academia. Rodger A. Liddle. Durham, NC How to get a job i n clinical practice. Jerome D. Waye. New York, NY

April1998

PROGRAMOF THEANNUALMEETINGP53

S S A T P O S T E R S E S S I O N - - M O N D A Y , M A Y 18, 1998 S O C I E T Y F O R T H E S U R G E R Y OF T H E A L I M E N T A R Y T R A C T SSAT Poster Session

8:00-5:00 p m

Hall D Ernest N. Morial Convention Center

Authors are required to present during the Poster Session from 12:00-2:30 pm

Those posters identified as DDW Posters of Distinction have received review scores that place them within the top 10% of all posters. We encourage you to make them a priority as you visit the poster session. P r o g n o s t i c v a l u e of Fas r e c e p t o r a n d RB p r o t e i n e x p r e s s i o n i n p a t i e n t s w i t h esophageal a d e n o c a r c i n o m a a r i s i n g i n B a r r e t t ' s metaplasia. (Abstract# S0049) D Coppola, L M0ra, R Schreiber, W Dalton and RC Karl. Tampa, FL Clinical a n d f u n c t i o n a l r e s u l t s of p r i m a r y laparoscopic m y o t o m y a n d a n t e r i o r f u n d o p l i c a t i o n for esophageal achalasia. (Abstract# S0031) L B0navina, G Micheletto, M Pagani, L Antoniazzi, R R0sati, A Segalin, G Marotta and A Peracchia. Milan, Italy M i n i m a l l y i n v a s i v e s u r g e r y for diffuse esophageal s p a s m a n d n u t c r a c k e r esophagus. (Abstract# S0258) D Tyrrell, MG Patti, M Arcerito, C Feo, J Tong, W Gantert and LW Way. San Francisco, CA

DDW Poster of Distinction: Bile s a l t - i n d u c e d m u t a t i o n in vitro. (Abstract# $0253) J Theisen, JH Peters, M Hughes, N Baril, K Skinner, CH Bremner, GMR Camp0s, OL Gastal, M Hashemi, D Nhera, TR DeMeester and PW Laird. Los Angeles, CA

DDW Poster of Distinction: R e s p i r a t o r y a n d p h a r y n g e a l symptoms: a c o m m o n m a n i f e s t a t i o n i n p a t i e n t s w i t h gastroesophageal reflux disease. (Abstract# S0116) WKH Kauer, A Balint, HJ Stein, H FeuSner and JR Siewert. Munich, Germany The p21 c y c l i n - d e p e n d e n t k i n a s e protects esophageal c a r c i n o m a cells from r a d i a t i o n . (Abstract# S0209) DA Rigberg, FS Kim, TA Blinman, J S0 and DW McFadden. Los Angeles, CA

DDW Poster of Distinction: I m m u n o h i s t o c h e m i c a l a s s e s s m e n t of 17-1A a n d c o m p l e m e n t r e s i s t a n c e factors CD55 a n d CD59 i n esophageal cancer. (Abstract# 80093) SB Hosch, S Inndorf, S Bull, F Stern, K Pantel and JR Izbicki. Hamburg and Munich, Germany V i d e o s u r g e r y esophagectomy. (Abstract# 80198) HW Pinotti, CE Domene, MA Santo, P V01pe, P Onari and F Atui. Sa0 Paulo, Brazil

D D W Poster of Distinction: Intratracheal long term pH monitoring: a new method to e v a l u a t e episodes of silent a s p i r a t i o n i n p a t i e n t s after e s o p h a g e c t o m y a n d gastric p u l l up. (Abstract# S0US) WKH Kauer, HJ Stein, HJ Bartels and JR Siewert. Munich, Germany

Surgery of g a s t r o d u o d e n a l ulcer: e v o l u t i o n of surgical r e c r u i t m e n t (1972-1996). (Abstract# S0095) O Huber, JM Megevand, R Chautems, P Majno and P Morel. Geneva, Switzerland

DDW Poster of Distinction: Functional and symptomatic improvement in patients with d i a b e t i c g a s t r o p a r e s i s following pyloroplasty. (Abstract# S0003) ZE Abouezzi, WS Melvin, EC Ellison and WJ Schirmer. Columbus, OH

DDW Poster of Distinction: Survival of gastric c a n c e r p a t i e n t s is d e t e r m i n e d by the p r e s e n c e of l y m p h a n g i t i s c a r c i n o m a t o s i s . (Abstract# $0225) GP Schwab, A Klingler, G Wetscher, M Gadenst~itter, HG Schwelberger, A Kreczy and R Pointner. Innsbruck, Austria Body c o m p o s i t i o n a s s e s s m e n t i n p a t i e n t s following gastric b y p a s s s u r g e r y for m o r b i d obesity. (Abstract# S0229) JL Sebastian, I Yip, M Flechtner-Mars, S Uikema, D Heber and EH Livingston. Los Angeles, CA Roux-en-Y gastric by-pass after p r e v i o u s u n s u c c e s s f u l gastric b a r i a t r i c s u r g e r y - e a r l y results. (Abstract# 80272) A Westling, M Ljungdahl and S Gustavsson. Uppsala, Sweden Clinical outcome a n d q u a l i t y of life after gastric a n d distal esophagus r e p l a c e m e n t w i t h a n ileocolon i n t e r p o s i t i o n . (Abstract# 80161) J Metzger, M v0n Flfie, L Degen, C Beglinger and F Harder. Basel and Lucerne, Switzerland Differing effects of a c a l c i t o n i n gene r e l a t e d p e p t i d e (CGRP) r e c e p t o r a n t a g o n i s t a n d a n a-CGRP a n t i b o d y o n postop ileus. (Abstract# S0068) ME Freeman, G Cheng and MP Hocking. Gainesville, FL Assessment of colonic p e r f u s i o n d u r i n g colonic r e s e c t i o n u s i n g s c a n n i n g l a s e r Doppler flowmetry. (Abstract# G2326) NH Boyle, WJ Owen, AC Pearce and RC Mason. London, United Kingdom Basic electrical r h y t h m a c t i v i t y as a m e a s u r e of bowel viability d u r i n g m e s e n t e r i c i s c h e m i a a n d r e p e r f u s i o n . (Abstract# 80133) JK Ladipo, SA Seidel, LA Bradshaw, S Halter and WO Richards. Nashville, TN E n d o t h e l i n a n t a g o n i s m r e d u c e s the systemic i n f l a m m a t o r y r e s p o n s e i n a m u r i n e model of i n t e s t i n a l ischemia/reperfusion. (Abstract# S0134) JS Lane, KE Todd, DA Rigberg, B G10or, AD Kau, SW Ashley, DW McFadden, HA Reber and CF Chandler. Los Angeles, CA and Boston, MA N-acetylcysteine a b r o g a t e s t h e systemic r e s p o n s e to m u r i n e i n t e s t i n a l i s c h e m i a / r e p e r f u s i o n . (Abstract# $0208) DA Rigberg, TA Blinman, JS Lane, FS Kim, OJ Hines, DW McFadden and CF Chandler. Los Angeles, CA I n t e s t i n a l t r a n s p l a n t s show i m p a i r e d r e g u l a t i o n of t r a n s i t i n short gut s y n d r o m e . (Abstract# S0110) CP Johnson, SK Sarna, YR Zhu, G Telford, AM Roza and MB Adams. Milwaukee, WI

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POSTER

GASTROENTEROLOGYVol. 114r No.4 I! SESSION

-- MONDAY,

MAY

18, 1998

I| Small bowel t r a n s p l a n t a t i o n alters n o n - a d r e n e r g i c noncholinergic i n h i b i t i o n i n l o n g i t u d i n a l s m o o t h muscle of t h e r a t j e j u n u m . (Abstract# S0019) BM Balsiger, N Ohtani, C Shibata, MM Murr, WJ Anding, JA Duenes and MG Sarr. Rochester, MN Ileal a b s o r p t i v e a d a p t a t i o n to j e j u n a l r e s e c t i o n a n d extrinsic d e n e r v a t i o n : i m p l i c a t i o n s for l i v i n g r e l a t e d small bowel t r a n s p l a n t a t i o n . (Abstract# 80257) GG Tsiotos, K Bierens, J Duenes and MG Sarr. Rochester, MN

iS Clinical s u b t y p e s of C r o h n ' s disease a c c o r d i n g to surgical outcome. (Abstract# S0079) SE Greenway, MA Buckmire and RH RolandeUi. Philadelphia, PA S t r i c t u r e p l a s t i e s for colonic stenosis i n C r o h n ' s disease. (Abstract# S0074) Y Funayama, I Sasaki, H Naito, K Fukushima, C Shibata, T Masuko, K-i Takahashi, H Ogawa, S Sato, T Ueno, S Sato, T Ueno, A Hashimoto and S Matsuno. Sendal, Japan

The d i f f e r e n t i a l effect of h e p a t o c y t e g r o w t h factor o n i n t e s t i n a l a d a p t a t i o n d e p e n d s o n the t i m i n g of exposure. (Abstract# S0U4) Y Kato, K Alavi, D Yu and MZ Schwartz. Wilmington, DE and Philadelphia, PA

Renal transplant patients with autosomal dominant polycystic k i d n e y disease are at i n c r e a s e d r i s k for complicated d i v e r t i c u l a r disease of the colon. (Abstract# S0015) NN Armstrong, AM D'Alessandro, JS Odorico, M Kalayoglu, HW Sollinger and SJ Knechtle. Madison, WI

Differential e x p r e s s i o n of l u m i n a l Na+/H+ exchanger isoforms i n the i l e u m following massive i n t e s t i n a l resection. (Abstract# S0234) CE Shin, M Soleimani, H Amlal, RA Falcone, Jr and BW Warner. Cincinnati, OH

Desmoid t u m o r s i n familial a d e n o m a t o u s polyposis. (Abstract# S0242) C Soravia, T Berk, RS McLeod and Z Cohen. Toronto, Canada

I n t e s t i n a l cell d i f f e r e n t i a t i o n is associated with decreases i n Star p r o t e i n s . (Abstract# S0271) S Wang and BM Evers. Galveston, TX A b d o m i n a l s u r g e r y r e s u l t s i n early Star p r o t e i n activation within the rat intestinal muscularis. (Abstract# S0U2) JC Kalff, C Hierholzer, WH Schraut, TR Billiar, DJ Tweardy and AJ Bauer. Pittsburgh, PA Effects of b u r n a n d s t a r v a t i o n o n small bowel mucosal apoptosis i n rats. (Abstract# S0053) M DebRoy, SE Wolf, H Ikeda, S Matin, S Rajaraman, DN Herndon and JC Thompson. Galveston, TX The c o n t i n e n t ileostomy: long t e r m d u r a b i l i t y a n d p a t i e n t satisfaction. (Abstract# S0142) VR Litle, S Barbour, TR Schrock and ML Welton. San Francisco, CA The role of t r a n s f o r m i n g g r o w t h factor beta-1 i n p e r i t o n i t i s - i n d u c e d adhesions. (Abstract# S0076) AM Ghellai, N Chegini, Q Dou, JM Kaseta, JW Burns, KC Skinner, AF Stucchi and JM Becker. Boston and Cambridge, MA; Gainesville, FL The s o d i u m t r a n s p o r t - d e p e n d e n t a b s o r p t i v e r e s p o n s e of colonic e p i t h e l i u m to p e p t i d e YY is decreased i n a q u a p o r i n - 4 k n o c k o u t mice. (Abstract# S0270) KS Wang, T Ma, AR Komar, I Cross, AS Verkman and JA Bastidas. Stanford and San Francisco, CA

DDW Poster of Distinction: A t t e n u a t e d familial a d e n o m a t o u s polyposis: association of age a n d polyp c h a r a c t e r i s t i c s w i t h colorectal cancer. (Abstract# S0004) DR Adams, CA Ternent, KM Lin, P Watson, AG Thors0n, GJ Blatchford, MA Christensen and HT Lynch. Omaha, NE

DDW Poster of Distinction: Results of a 3-year s u r v e i l l a n c e p r o g r a m of m e m b e r s of families w i t h h e r e d i t a r y non-polyposis colorectal cancer. (Abstract# S0214) GB Rossi, M de Bellis, P Marone, PF Malone, L Panariello, F Petrulio, A Tempesta and P Izzo. Naples, Italy CEA is useful to d e t e r m i n e the n e e d for a p r e o p e r a t i v e CT s c a n i n p a t i e n t s with colorectal cancer. (Abstract# s0ug) S Kelly and MA Malangoni. Cleveland, OH

DDW Poster of Distinction: S u p p r e s s i o n of e n d o n u c l e a s e e x p r e s s i o n b y n o n s t e r o i d a l a n t i i n f l a m m a t o r y d r u g s (NSAIDs) i n sporadic colorectal cancer. (Abstract# S0111) MS Kahlenberg, C Volpe, DL Stoler, NJ Petrelli and GR Anderson. Buffalo, NY

In vitro g r o w t h of colon t u m o r s p r e d i c t s p o o r e r long t e r m survival. (Abstract# S0060) TM Farrell, OS Pettengill, DS Longnecker, K Sullivan and KH Cohn. Lebanon, NH

Effect of N e o s t i g m i n e o n p o s t o p e r a t i v e colonic motility. C o m b i n e d m a n o m e t r y / b a r o s t a t recordings. (Abstract# S0128) ME Kreis, A Huge, TT Zittel, M Kasparek, G Thiers, MJ Starlinger, HD Becker and EC Jehle. Tiibingen, Germany

DDW Poster of Distinction:

DDW Poster of Distinction:

Rectal cancer: the i m p a c t of h i g h dose p r e o p e r a t i v e i r r a d i a t i o n o n distal surgical m a r g i n s . (Abstract#

C o m p a r i s o n of m e a s u r e m e n t m e t h o d s c a l c u l a t i n g r e c o v e r y of g a s t r o i n t e s t i n a l m o t i l i t y following surgery. (Abstract# S0103) M Ishikawa, M Hotokezaka, MC Blair and BD Schirmer. Charlottesville, VA Ogilvie's s y n d r o m e i n t h e surgical p a t i e n t : a n e w t h e r a p e u t i c modality. (Abstract# S0224) CR Schermer, JJ Hanosh, M Davis and DE Pitcher. Albuquerque, NM

II

Laparoscopic total m e s o r e c t a l excision a n d a u t o n o m i c n e r v e p r e s e r v a t i o n i n a c a d a v e r model. (Abstract# S0107) BL Jerby, H Kessler, PW Marcell0, T Gramlich and JW Milsom. Cleveland, OH

S0153) J Marks, J Cotter, G Marks and M Mohiuddin. Philadelphia, PA and Lexington, KY

DDW Poster of Distinction: P r e o p e r a t i v e c h e m o r a d i o t h e r a p y p e r m i t s < l c m distal m a r g i n a n d s p h i n c t e r p r e s e r v a t i o n for d i s t a l rectal cancer. (Abstract# S0132) BW Kuvshin0ff, I Magfoor, B Miedema, J Wilkes, S Westgate and DM Ota. Columbia, MO

PROGRAMOF THEANNUALMEETINGP55

S S A T P O S T E R S E S S I O N - - M O N D A Y , MAY 18, 1998 The role of l a p a r o s c o p y i n the t r e a t m e n t of m i d a n d low r e c t a l c a n c e r lesions. Is it safe a n d feasible? (Abstract# S0067) ME Franklin, D Abrego, JE Balli, JP Dorman, JL Glass, H Martinez and C Pefina. San Antonio, TX F a s c i a l closure decreases p o r t site i m p l a n t a t i o n following l a p a r o s c o p y i n a r a t p e r i t o n e a l seeding model. (Abstract# S0109) AB Johnson, D Dfllehay, K Macken, GW Daneker and JG Hunter. Atlanta, GA C o n t i n e n c e f u n c t i o n i n p a t i e n t s w i t h rectal prolapse: pre- a n d p o s t o p e r a t i v e m a n o m e t r i c findings. (Abstract# S0168) SM Muehldorfer, KE Matzel, U Stadelmaier, T Schneider and EG Hahn. Erlangen, Germany A pudendal nerve innervated sartorius neoanal s p h i n c t e r . A c a n i n e model. (Abstract# S0181) DCNK Nyam. Singapore, Singapore T o w a r d s a b e t t e r d e f i n i t i o n of h e m a n g i o m a s of t h e r e c t u m . (Abstract# S0221) JM Sarmiento, S Nivatvongs and S Zaheer. Rochester, MN C a r b o x y p e p t i d a s e A activity i n p a n c r e a t i c c a n c e r a n d acute p a n c r e a t i t i s . (Abstract# S0232) P Shamamian, S Marcus, E Deutsch, T Maldonado, A Liu, J Stewart, K Eng and C Gilvarg. New York, NY and Princeton, NJ AGM-1470 r e d u c e s v a s c u l a r i z a t i o n of the ductal p a n c r e a t i c c a r c i n o m a . I n t r a v i t a l microscopic o b s e r v a t i o n s i n t h e dorsal skin-fold c h a m b e r of t h e r a t a n o v e l m o d e l for e v a l u a t i n g a n t i a n g i o g e n e t i c t h e r a p y . (Abstract# S0094) HG Hotz, T Foitzik, B H0tz, G Eibel, A Menrath, HA Reber and HJ Buhr. Berlin, Germany and Los Angeles, CA -

Severe h y p e r s t i m u l a t i o n ] o b s t r u c t i o n p a n c r e a t i t i s : a model c h a r a c t e r i z e d b y a c i n a r a t r o p h y a n d i n t e r s t i t i a l p a n c r e a t i c fibrosis. (Abstract# S0169) K Murayama, B Barent, A Brooks, M Gruber, S Eliason, E Brunt and G Smith. St Louis, MO and Omaha, NE I n f l u e n c e of c o n t r a s t m e d i u m a n d octreotide o n the d e v e l o p m e n t of p a n c r e a t i c necrosis. (Abstract# S0259) W Uhl, MW Biichler and the German Pancreatitis Study Group. Bern, Switzerland

DDW Poster of Distinction: Matrix m e t a l l o p r o t e i n a s e 2 a n d 9 activity i n e x p e r i m e n t a l a c u t e p a n c r e a t i t i s . (Abstract# S0188) S Patol, J Schwartz, N Chaung, SG Marcus, HL Pachter, E Deutsch, AC Galloway, K Eng, P Mignatti and P Shamamian. New York, NY Acute p a n c r e a t i t i s following c a r d i a c t r a n s p l a n t a t i o n is s i g n i f i c a n t l y i n c r e a s e d c o m p a r e d with other cardiac p r o c e d u r e s . (Abstract# S0085) AJ Herline, J Debelak, CW Pinson, D Harley, W Merrill, T Starkey, R Pierson and WC Chapman. Nashville, TN R e g u l a t i o n of p a n c r e a t i c d u c t cell growth b y t r a n s f o r m i n g g r o w t h factor b e t a i~ v/fro. (Abstract# S0008) C Alvarez and BL Bass. Baltimore, MD Apoptosis i n h i b i t i o n d e t e r i o r a t e s the prognosis i n p a n c r e a t i c cancer. (Abstract# S0070) H Friess, Z Lu, A Andren-Sandberg, A Zimmermann, G Adler, R Schmid and WW Btichler. Bern, Switzerland and Ulm, Germany

Magnetic r e s o n a n c e i m a g i n g w i t h m a g n e t i c r e s o n a n c e cholangiopancreatography predicts resectability and ductal abnormalities in benign and malignant p a n c r e a t i c disease, (Abstract# S0088) SN Hochwald, M Dobryansky, N Rofsky, P Shamamian and SG Marcus. New York, NY The role of p o s i t r o n emission t o m o g r a p h y i n the diagnosis a n d s t a g i n g of p a n c r e a t i c cancer. (Abstract# S0044) L Clark, RA Perez-Tamayo, H Hurwitz, S Branch, J Baillie, P Jowell, E Coleman, T Pappas, M Keogan and D Tyler. Durham, NC

DDW Poster of Distinction: I n t r a o p e r a t i v e u l t r a s o u n d i m p r o v e s diagnostic a n d t h e r a p e u t i c strategies d u r i n g p a n c r e a t i c surgery. (Abstract# S0084) RJ Hendrickson, CM Schmidt, CR Cappadona, LT Tio and JV Sitzmann. Washington, DC R e e x p l o r a t i o n for p e r i a m p u l l a r y c a r c i n o m a : resectability, p e r i o p e r a t i v e r e s u l t s , pathology a n d long t e r m outcome. (Abstract# S0241) TA S0hn, KD Lfllem0e, JL Cameron, HA Pitt, J Huang, RH Hruban and CJ Ye0. Baltimore, MD P r e s u m e d m a l i g n a n t b i l i a r y o b s t r u c t i o n despite a n o r m a l CT: d a t a to s u p p o r t p a n c r e a t i c o d u o d e n e c t o m y . (Abstract# S0033) M Bouvet, R B01d, J Lee, P Pisters, J Abbruzzese, I Raijman, C Charnsangavej and DB Evans. Houston, TX Delayed gastric e m p t y i n g occurs after b o t h classical a n d p y l o r u s - p r e s e r v i n g Whipple p r o c e d u r e . (Abstract# S0012) A Andr6n-Sandberg, M Wagner, HU Bauer, W Uhl, H Friess and MW Btichler. Bern, Switzerland

DDW Poster of Distinction: Quality of life d u r i n g the first y e a r after P P P D for p e r i a m p u l l a r y c a r c i n o m a . (Abstract# S0178) EJ Nieveen van Dijkum, CB Terwee, JH vd Meulen, HC de Haes, JJB van Lanschot and DJ Gouma. Amsterdam, The Netherlands

DDW Poster of Distinction: The i m p a c t of s p l e n e c t o m y o n o u t c o m e after r e s e c t i o n of p a n c r e a t i c a d e n o c a r c i n o m a . (Abstract# S0226) RE Schwarz, LE Harrison, DS Klimstra and MF Brennan. Duarte, CA and New York, NY The effect of a n e i c o s a p e n t a n o i c a c i d - e n r i c h e d n u t r i t i o n a l s u p p l e m e n t i n weight-losing p a t i e n t s w i t h a d v a n c e d p a n c r e a t i c cancer. (Abstract# S0020) MD Barber, JA Ross, KCH Fearon and AC Voss. Edinburgh, Scotland Cancer of the p a p i l l a (ampulla) of Vater: clinicopathological a n d m o l e c u l a r factors i n f l u e n c i n g survival a n d t r e a t m e n t . (Abstract# S0098) C Iacono, A Scarpa, G Zamboni, G Verlato, L Bortolasi, A Baron and G Serio. Verona, Italy The role of i n t r a o p e r a t i v e i n s u l i n m o n i t o r i n g i n surgical m a n a g e m e n t of i n s u l i n o m a . (Abstract# S0009) K Amikura, R Nakamura, K Arai, M Kobari and S Matsuno. Sendal, Japan

P56 PROGRAMOFTHEANNUALMEETING II

SSAT

POSTER

GASTROENTEROLOGYVol.1141No. 4 SESSION

DDW Poster of Distinction: Treatment with anti-interleukin-12monoclonal a n t i b o d y alleviates a c u t e r e j e c t i o n of m o u s e islet allografts. (Abstract# S0266) Y Wada, K Arai, M Sunamura, M Kobari and S Matsuno. Sendal, Japan

DDW Poster of Distinction: G e n e r a t i o n of a t i s s u e specific t r a n s g e n i c mouse model u s i n g CRE r e c o m b i n a s e l i n k e d to a n i n s u l i n promoter. (Abstract# S0202) MK Ray, FJ DeMayo and FC Brunicardi. Houston, TX Antithrombin III reduces leukocyte-endothelial i n t e r a c t i o n after w a r m h e p a t i c i s c h e m i a i n rats. (Abstract# S0152) S-M Maksan, MM Gebhard, M-O Maksan, C Herfarth and E Klar. Heidelberg and Bonn, Germany A r t e r i a l e m b o l i z a t i o n s i g n i f i c a n t l y i m p r o v e s the h y p e r t h e r m i c effect of l a s e r - i n d u c e d t h e r m o t h e r a p y i n liver m e t a s t a s i s i n rats. (Abstract# S0007) D Albrecht, C Germer, C Isbert, A Roggan, HP Ritz, D Schuppan and HJ Buhr. Berlin, Germany

DDW Poster of Distinction: Preconditioning protects against ischemia-reperfusion i n j u r y of the liver. (Abstract# S0179) B Nilsson, B Gustafsson, S Friman and D Delbro. GSteborg, Sweden Definitive t r e a t m e n t of g i a n t h e p a t i c h e m a n g i o m a s : e n u c l e a t i o n v e r s u s resection. (Abstract# 80037) JF Buell, LB Johnson, PC Kuo, JS Plotkin, R GedalyEidelman, WD Lewis and RL Jenkins. Baltimore, MD and Boston, MA Do h e p a t i c r e s e c t i o n s n e e d to be p e r f o r m e d at highv o l u m e r e f e r r a l centers? (Abstract# S0204) WP Reed, BA Halla and JL Garb. Springfield, MA P r o g n o s t i c factors after h e p a t e c t o m y for h e p a t o c e l l u l a r c a r c i n o m a . (Abstract# S0136) H Lau, ST Fan, I Ng and J Wong. Hong Kong, PR China Effect of a n i n i t i a l positive m a r g i n o n the prognosis of p a t i e n t s u n d e r g o i n g liver r e s e c t i o n for h e p a t o c e l l u l a r c a r c i n o m a . (Abstract# S0096) GR Huffman, A Uzar and MA Choti. Baltimore, MD Liver r e s e c t i o n for n o n c o l o r e c t a l n o n n e u r o e n d o c r i n e h e p a t i c metastases. (Abstract# S0238) TD Sielaff, B Langer, T Van der Meet, BR Tayl0r, PD Greig, S Gallinger and AW Hemming. Toronto, Canada A p p l i c a t i o n of l i v i n g - r e l a t e d a n d split-liver t r a n s p l a n t a t i o n to adults: a n a n a t o m i c study. (Abstract# 80205) PR Reichert, JF Renz, RC Lim, JP Roberts and NL Ascher. San Francisco, Ca B i l i a r y c y s t a d e n o m a : a n o n g o i n g d i a g n o s t i c challenge. (Abstract# S0260) TJ VanderMeer, TD Sielaff, A Blumenfeld, BR Taylor and B Langer. Toronto, Canada Effective t o x i n gene e x p r e s s i o n via a d e n o v i r a l infection of h u m a n c h o l a n g i o c a r c i n o m a cells i n the p r e s e n c e of h u m a n bile. (Abstract# S0190) LC Pederson, DJ Buchsbaum, MA Stackhouse, DT Curiel and SM Vickers. Birmingham, AL

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MAY

18, 1998

IL-I~ s t i m u l a t e s m u c u s s e c r e t i o n i n g a l l b l a d d e r epithelial cells. (Abstract# S0043) CH Cheung, JB Prytowsky, EW Moore and RV Rege. Chicago, IL and Richmond, VA A n i o n e x c h a n g e r AE-2 m e d i a t e s chloride t r a n s p o r t b y gallbladder epithelium. (Abstract# S0167) AJ Moser, K Graf, ZR Abedin, KE Morgenstern, PR Smith, JJ Roslyn and MZ Abedin. Philadelphia, PA I r o n deficiency i n h i b i t s g a l l b l a d d e r motility. (Abstract# S0171) KP Murray, JH Shin, MK Fox-Talbot, SM Johnston, PA Lipsett, KD Lillemoe and HA Pitt. Baltimore, MD and Milwaukee, WI M a n a g e m e n t of d u o d e n a l p e r f o r a t i o n after endoscopic r e t r o g r a d e c h o l a n g i o p a n c r e a t o g r a p h y . (Abstract# 80244) MV Stapler, R Yang, N Jabour, SC Stain, R Selby and D Garry. Los Angeles, CA ERCP-associated d u o d e n a l p e r f o r a t i o n u s u a l l y c a n be t r e a t e d non-operatively. (Abstract# S0045) RB Clayt0r, FJ Vittimberga, M Malik, J Saltzman, P Krims, MP Caller] and RS Swanson. Worcester, MA I n t r a o p e r a t i v e b i l i a r y m a n o m e t r y i n the e v a l u a t i o n of chronic acalculous cholecystitis. (Abstract# S0147) SW Lucas and ME Arregui. Indianapolis, IN What makes for a satisfied p a t i e n t t h r e e m o n t h s after cholecystectomy? A n outcomes a n a l y s i s of 1325 patients. (Abstract# S0255) LW Traverso, R Lonb0rg and LF Fenster. Seattle, WA Mini-laparoscopic cholecystectomy: e v a l u a t i n g a n e w approach. (Abstract# S0203) PR Reardon, JI Kamelgard, BA Applebaum and FC Brunicardi. Houston, TX P r e o p e r a t i v e ERCP is m o r e costly t h a n i n t r a o p e r a t i v e or p o s t o p e r a t i v e endoscopic a n d surgical t e c h n i q u e s i n the m a n a g e m e n t of choledocholithlasis. (Abstract# 80083) JW Hazey, LM Rock, JM Marks, D Asseff and JL Ponsky. Cleveland, OH C h o l a n g i o g r a p h y d u r i n g l a p a r o s c o p i c cholecystectomy c u m u l a t i v e s u m analysis of a n i n s t i t u t i o n a l l e a r n i n g curve. (Abstract# S0163) M Molloy, SB Archer, PO Hasselgren, BJ Dalton and RH Bower. Cincinnati, OH

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Declining r a t e of c o m m o n bile d u c t operations: a statewlde, five-year time-series analysis. (Abstract# S0097) T Huynh, R Rutledge, JS Guy and CC Baker. Chapel Hill, NC 84b+S5 r e s e c t i o n with total c a u d a t e lobectomy u s i n g Taj Mahal liver i n c i s i o n for c a r c i n o m a of the b i l i a r y tract. (Abstract# S0118) Y Kawarada, M Tabata, K Yamagiwa, H Taoka, S Isaji, H Yokoi, Y Ogura and T Noguchi. Mie, Japan C 3 a , e n d o t o x i n a n d e n d o t o x i n - n e u t r o l i z i n g c a p a c i t y as predictors of s u r v i v a l i n p e r i t o n i t i s . (Abstract# S0036) T Briickner, R Urbaschek, E Klar and C Herfarth. Heidelberg and Mannheim, Germany

The t h o r a c i c duct is n o t a m a j o r r o u t e of b a c t e r i a l t r a n s l o c a t i o n i n p a t i e n t s w i t h m u l t i p l e o r g a n failure. (Abstract# S0138) LCJM Lemaire, JJB van Lansch0t, CP Stoutenbeek, SJH van Deventer, J Dankert and DJ G0uma. Amsterdam, The Netherlands

April 1998

PROGRAMOF THE ANNUALMI~.~TINGP57

A r e s t a p l e d a n a s t o m o s e s i n GI s u r g e r y j u s t i f i e d ? (Abstract# S0075) KA Gawad, JR Izbicki, SB Hosch, S Quirrenbach, WT Knoefel, H-U Kfipper and CE Broelsch. Hamburg and Munich, Germany

SSAT Consensus 2:15-5:30 p m

Room 103 / 104 Ernest N. Morial Convention Center

INTRODUCTION: Prevalence/frequency. C r i t e r i a of u n r e s e c t a b i l i t y / % u n r e s e c t a b i l i t y . Multidisciplinary management. Natural history-brief. Speaker: David Nagorney. Rochester, MN

L a p a r o s c o p i c b o w e l r e s e c t i o n i n C r o h n ' s p a t i e n t s offers m a n y a d v a n t a g e s o v e r o p e n s u r g e r y . (Abstract# S0131) MF Kutka, MA Talamini, H Kaufman, BK Poulose and RC Moesinger. Baltimore, MD

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I n t e r v a l a p p e n d e c t o m y in t h e l a p a r o s c o p i c era. (Abstract# S0176) DB Nguyen, W Silen and RA Hodin. Boston, MA

PALIATION OF JAUNDICE: Speaker: James Becket. Boston, MA Radiologic guided intervention. Speaker: Robert Hawes. Charleston, SC Endoscopic intervention. Speaker: David Cart-Locke. Boston, MA O p e r a t i v e *** b y p a s s . Speaker: H. Beget. Ulna, Germany. Gastrointestinal obstruction. Speaker: Michael Sarr. Rochester, MN Q u e s t i o n s to a n s w e r : 1) efficacy 2) d u r a b i l i t y 3) q u a l i t y of life, s u r v i v a l

R e t r o p e r i t o n e a l a n d m e s e n t e r i c cyst: c h a r a c t e r i s t i c s a n d s u r g i c a l m a n a g e m e n t . (Abstract# S0199) BK Poulose, MF Kutka, MA Talamini, KD Lillemoe and JL Cameron. Baltimore, MD

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TPN affects h u n g e r b u t n o t s a t i e t y i n female r a t s . (Abstract# S0127) V Kotha, M Varma, Z-J Yang, C Chen and MM Meguid. Syracuse, NY

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DDW Poster of Distinction: A b d o m i n a l t u b e r c u l o s i s . (Abstract# 80006) (~ Alabaz and A Akino~lu. Adana, Turkey SSAT Scientific Presentations 2:15-3:45 p m Room 97/98 Ernest N. Morial Convention Center

PALLIATION O F PAIN: Speaker: Robin McLeod. Toronto, Canada Operation Speaker: Keith Lillemoe. Baltimore, MD Anesthesia Speaker: Gilbert Wong. Rochester, MN -

Chairs: Barbara Bass, Mark Talamini

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RESEARCH PAPERS I 2:15

2".28

Cyclin D3 is e s s e n t i a l for i n t e s t i n a l e p i t h e l i a l cell p r o l i f e r a t i o n . (Abstract# S0123) TC Ko, F Pan, DB Brown, EA Thompson and RD Beauchamp. Galveston, TX and Nashville, TN

2:41

Extracellular matrix modulates enterocyte g r o w t h v i a d o w n r e g u l a t i o n of c-jun b u t is i n d e p e n d e n t of p21 a n d p27 expression. (Abstract# S0274) SI Wolpert, KM Lally, J Li, J-Y Wang and BL Bass. Baltimore, MD

2:54

3:07

3:20

3:33

TREATMENT OF UNRESECTABLE PANCREATIC CARCINOMA: Speaker: Greg Bulkley. Baltimore, MD Irradiation: external beam irradiation/IORT Speaker: Christopher Willett. Boston, MA

T h e e n t e r o t r o p h i c effects of glucagon-like peptide 2 are enhanced by neurotensin. (Abstract# S0143) DA Litvak, MR Hellmich, BM Evers and CM Townsend, Jr. Galveston, TX

Loss of m a t r i x - d e p e n d e n t c y t o s k e l e t a l t y r o s i n e kinase signals may regulate intestinal epithelial differentiation during mucosal h e a l i n g . (Abstract# S0145) Y-W Liu, MA Sanders and MD Basson. New Haven and West Haven, CT A p o s s i b l e r o l e for p21 i n a l t e r a t i o n of t h e enterocyte differentiation associated with p r e m a t u r e cell cycle w i t h d r a w a l . (Abstract# S0013) S Archer, S Meng and RA Hodin. Boston, MA Effect of n u t r i t i o n a l r o u t e on colonic a n a s t o m o t i c h e a l i n g i n t h e r a t . (Abstract# S0121) T Kiyama, DT Efron, U Tantry and A Barbul. Baltimore, MD Calcium accentuates gastric injury induced by e t h a n o l . (Abstract# S0125) ER Kokoska, GS Smith and TA Miller. St Louis, MO

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I s s u e s to answer: 1) s u r v i v a l 2) q u a l i t y of life 3) p a l l i a t i o n , j a u n d i c e , p a i n , etc. 4) c o m p l i c a t i o n s Chemotherapy Speaker: Margaret Tempero. Omaha, NE

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Immunotherapy Speaker: Michael Lotze. Pittsburgh, PA

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CONSENSUS STATEMENT Conclusion: David Nagorney. Rochester, MN Combined Clinical Symposium 4:00-5:30 p m Ballroom C Ernest N. Morial Convention Center D

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S p o n s o r e d by: SSAT/AGA/ASGE

Chairs: James M. Becker, Mark A. Peppercorn CHRONIC U L C E R A T I V E C O L I T I S P a t h o p h y s i o l o g y of c h r o n i c u l c e r a t i v e colitis. R. Balfour Sartor. Chapel Hill, NC New m e d i c a l t h e r a p y for c h r o n i c u l c e r a t i v e colitis. Simon Lichtiger. New York, NY A d v a n c e s a n d c o n t r o v e r s i e s i n s u r g e r y for c h r o n i c u l c e r a t i v e colitis. Mark L. Welton. San Francisco, CA

P58 PROGRAMOF THEANNUALMEETING

GASTROENTEROLOGYVol. 114~No. 4 MONDAY~

SSAT Scientific Presentations

4:00-5:30 p m

~VL~kY 18~ 1 9 9 8 4:39

I n f l u e n c e of p53 s t a t u s o n the efficacy of HSVm e d i a t e d cancer gene t h e r a p y . ( A b s t r a c t # 80276) SS Yoon, NM Carroll, EA Chiocca and KK Tanabe. Boston, MA

4:52

T h e r a p y of m i c r o c i r c u l a t o r y d i s o r d e r s i n s e v e r e acute p a n c r e a t i t i s - w h a t is m o r e effective, platelet a c t i v a t i n g factor- or e n d o t h e l i n - r e c e p t o r blockade? (Abstract# S0065) T Foitzik, HG Hotz, B Hotz, G Eibl, M Kirchengast and HJ Buhr. Berlin and Ludwigshafen, Germany

5:05

C h a r a c t e r i s a t i o n a n d r e d u c t i o n of i s c h e m i a ] r e p e r f u s i o n - i n j u r y after e x p e r i m e n t a l p a n c r e a s - t r a n s p l a n t a t i o n . (Abstract# 80158) H Mayer, J Schmidt, J Thies, E Ryschich, MM Gebhard, C Herfarth and E Klar. Heidelberg, Germany

5:18

P r e v e n t i o n of e n d o t o x i n - i n d u c e d m o r t a l i t y is associated with blockade of b o t h PGE 2 s y n t h e s i s a n d c a l c i u m flux i n Kupffer cells. (Abstract# S02U) CR Roland, B Naziruddin, Y Nakafusa, T Mohanakumar and MW Flye. St Louis, MO

Room 97/98 Ernest N. Morial Convention Center

Chairs: Steven Raper, Jeffrey Peters RESEARCH PAPERS II 4:00

I n v o l v e m e n t of Fas i n t a m o x i f e n - i n d u c e d apoptosis of c h o l a n g i o c a r c i n o m a . (Abstract# S0192) A Pickens, G Pan, J McDonald and SM Vickers. Birmingham, AL

4:13

H u m a n p e r i a m p u l l a r y c a r c i n o m a s express c h o l e c y s t o k i n i n receptors. (Abstract# S0165) RA Moonka, W Zhou and RH Bell, Jr. Seattle, WA

4:26

G r o w t h factor r e c e p t o r a n t a g o n i s m results i n e n h a n c e d r e s p o n s e to c h e m o r a d i a t i o n t h e r a p y i n colon c a n c e r cells. (Abstract# S0237) A Shurin, E Perer, Y Pang, K Romaguera, E Zakris and DJ Beech. New Orleans, LA

II

April 1998

P R O G R A M O F T H E ANNUAL MEETING P59

II

MONDAY, MAY 18, 1998 AMERICAN SOCIETY FOR GASTROINTESTINAL ENDOSCOPY

ASGE Video Forum

DDW Combined Clinical Symposium

2:15-5.'30 p m

2:15-3:45 p m

Room 100 / 101 / 102 Ernest N. Morial Convention Center

Chairs: Stephen A. McClave, Blair S. Lewis Attendees will learn about new endoscopic advances in a video format. Endoscopic video highlighting endoscopic interventions in the GI tract and biliary tree will be shown.

Ballroom C Ernest N. Morial Convention Center

S p o n s o r e d by- AASLD/AGA/ASGE

Chairs: Nell Kaplowitz, Denis M. McCarthy I N T E R A C T I O N O F A C E T A M I N O P H E N AND N S A I D s W I T H ALCOHOL: N A M E Y O U R P O I S O N

C h o l e d o c h o s c o p i c s u r v e i l l a n c e for d y s p l a s i a in a patient with hepatolithiasis. Rayburn F. Rego, M.D. The University of Texas Medical Branch

2:15

A c e t a m i n o p h e n , a l c o h o l a n d l i v e r injury: Pathophysiological considerations. Neil Kaplowitz. Los Angeles, CA

C h a r a c t e r i s t i c c h o l a n g i o s c o p i c f i n d i n g s of b i l i a r y papillomatosis. Dong Wan Sea, M.D. Asan Medical Center

2:30

A c e t a m i n o p h e n , a l c o h o l a n d l i v e r injury: Clinical p r e s e n t a t i o n a n d extent of the

problem. William Lee. Dallas, TX

E n d o s c o p i c d e b r i d e m e n t of o r g a n i z e d p a n c r e a t i c necrosis. Todd H. Baron, M.D. Univ. of Alabama at Birmingham

2:50

E s o p h a g e a l i n v o l v e m e n t i n p e m p h i g u s vulgaris; r e p o r t of t h r e e cases. Miguel Munoz-Navas, M.D. University Hospital of Navarra

NSAIDs, alcohol a n d m u c o s a l i n j u r y : pathophysiological considerations. Andrzej Tarnawski. Long Beach, CA

3:05

NSAIDs, alcohol: c l i n i c a l i n t e r a c t i o n s . Denis M. McCarthy. Albuquerque, NM

E n d o s c o p i c r e s e c t i o n of a choledochocele. Mark Topazian, M.D. Yale University School of Medicine

3:25

Panel

Non-lifting s i g n for i n v a s i v e c o l o r e c t a l cancer. Yoshiharu Uno, M.D., Ph.D. Hirosaki University School of Medicine

4:00-5:30 p m

L a p a r o - e n d o s c o p i c e x c i s i o n of a d u o d e n a l mass. Keith S. Gersin, M.D. The Cleveland Clinic Foundation

S p o n s o r e d by: SSAT/AGA/ASGE

R e s o l u t i o n of s y m p t o m a t i c GERD a n d d e l a y e d g a s t r i c e m p t y i n g a f t e r e n d o s c o p i c a b l a t i o n of a n t r a l diaphragm. Martin E. Maldonado, M.D. Dig. Dis. & Nut., USF College of Medicine. Role of i n t r a d u c t a l u l t r a s o u n d i n s t a g i n g a n d e n d o s c o p i c m a n a g e m e n t of a m p u l l a r y a d e n o m a . Irving Waxman, M.D. University of Texas Medical Branch B l u e R u b b e r Bleb Nevus S y n d r o m e .

John C. Cozart, M.D. Washington University School of Medicine D i e u l a f o y ' s Lesion, t h e r a p e u t i c options. Vipul H. Shah, M.D. Columbia University College of Physicians & Surgeons E n d o s c o p i c m u c o s a l r e s e c t i o n for s h o r t - s e g m e n t B a r r e t t ' s e s o p h a g u s as a t o t a l b i o p s y a n d t r e a t m e n t . Haruhiro Inoue, M.D. Tokyo Medical & Dental University A case of c r e e p i n g t u m o r i n r e c t u m t r e a t e d b y e n d o s c o p i c m u c o s a l r e s e c t i o n (The EMRC P r o c e d u r e ) . Haruhiro Inoue, M.D. Tokyo Medical & Dental University E U S a n d I D U S ( i n t r a d u c t a l US) i n a s s e s s i n g t u m o r s of

the papilla. Lok T. Tio, M.D. Georgetown University Hospital Endoscopy in boric acid and mercuric cyanide ingestion. William Mayoral, M.D. Georgetown University Hospital E n d o - c l i p p i n g of a b l e e d i n g Mallory-Weiss tear. Stephen Goodman, M.D. Columbia-Presbyterian Medical Center The e n d o s c o p y of t h e screw. Blair S. Lewis. Mt. Sinai Medical Center

DDW Combined Clinical Symposium

Ballroom C Ernest N. Morial Convention Center

Chairs: James M. Becker, Mark A. Peppercorn CHRONIC U L C E R A T I V E C O L I T I S P a t h o p h y s i o l o g y of c h r o n i c u l c e r a t i v e colitis. R. Balfour Sartor. Chapel Hill, NC N e w m e d i c a l t h e r a p y for c h r o n i c u l c e r a t i v e colitis.

Simon Lichtiger. New York, NY A d v a n c e s a n d c o n t r o v e r s i e s i n s u r g e r y for c h r o n i c u l c e r a t i v e colitis. Mark L. Welten. San Francisco, CA

P60 PROGRAMOFTHEANNUALMEETING

GASTROENTEROLOGYVol. 114~No. 4

MONDAY, MAY 18, 1998 T H E A M E R I C A N GASTROENTEROLOGICAL A S S O C I A T I O N THE A M E R I C A N ASSOCIATION F O R THE STUDY OF LIVER D I S E A S E S 1998 Focused Clinical/Research Updates

TOPIC Endoscopic technoloBT Barrett's esophagus Enteral - parenteral nutrition Hepatitis C IBD - therapy Hemochromatosis H. pylori - therapy Non-variceal GI bleeding Metaplasia, dysplasia and pre-mali~nant disease Hepatic fibrosis Brain-gut axis IBD and cancer

AGA Plenary Session

8:00-12:00 p m

Hall C Ernest N. Morial Convention Center

Chairs: Phillip Toskes, Thomas Brasitus 8:00

Welcome. Thomas A. Brasitus. Chicago, IL

8:05

N e o s t i g m i n e for the t r e a t m e n t of acute colonic p s e u d o - o b s t r u c t i o n : a r a n d o m i z e d , doubleb l i n d , c o n t r o l l e d trial. (Abstract# G0140) RJ Ponec, MD Saunders and MB Kimmey. Seattle, WA

8:20

Effects of c u r i n g Helicobacter pyloriinfection on p r e c a n c e r o u s gastric lesions: one-year follow-up of a p r o s p e c t i v e r a n d o m i z e d s t u d y i n China. (Abstract# G1215) JY Sung, SR Lin, JYL Ching, LY Zhou, KF To, RT Wang, WK Leung, LX Wang, EKW Ng, YT Lee, JYW Lau, SCS Chung and W Chao. Hong Kong and Beijing, China

8:35

Title TBA. Jerome Kassirer, Boston, MA

8:55

D i s t i n g u i s h e d E d u c a t o r Award. Willis C. Maddrey. Dallas, TX

8:58

D i s t i n g u i s h e d C l i n i c i a n Awards. Edgar Aehkar. Cleveland, OH James L. Borland, Jr. Jacksonville, FL Horacio H, Jinich. San Diego, CA Burton I. Korelitz. New York, NY Robert H. Shapiro. Boston, MA

9:08

F r e i d e n w a l d Award/Video Eugene Jacobson. Denver, CO

9:20

Helieobacterpylori u r e a s e b i n d s to class II MHC molecules o n gastric epithelial cells to i n i t i a t e apoptosis. (Abstract# G0485) XJ Fan, H Gunasena, M Gonzales, R Almanza, Z Cheng, G Ye, C Barrera, SE Crowe, PB Ernst and VE Reyes. Galveston, TX

9:34

h P E P T l - m e d i a t e d epithelial t r a n s p o r t of b a c t e r i a - d e r i v e d chemotactic peptides enhances neutrophil-epithelial interactions. (Abstract# G1623) D Merlin, A Steel, AT Gewirtz, MA Hediger and JL Madara. Atlanta, GA and Boston, MA

SPEAKER David Carr-Locke~ M.D. Richard E. Sampliner, M.D. Alan L. Buchman~ M.D. Karen L. Lindsay~ M.D. Mark A. Peppercorn~ M.D. Bruce R. Bacon~ M.D. Walter Peterson~ M.D, Dennis M. Jensen, M.D. Cyrus Rubin, M.D. Jacquelyn J. Maher~ M.D. Yvett Tach~ M.D., Ph.D. Bret Lashner, M.D.

9:48

D i s t i n g u i s h e d A c h i e v e m e n t Award. John Walsh. Los Angeles, CA

10:08

AGA P r e s i d e n t ' s Address. Phillip P. Toskes. GainesviUe, FL

10:23

Lifetime A c h i e v e m e n t Award.

10:28

Significance of heterozygous cystic fibrosis gene (cystic fibrosis t r a n s m e m b r a n e conductance regulator mutations) in i d i o p a t h i c p a n c r e a t i t i s . (Abstract# G1819) CP Choudari, AC Yu, TF Imperiale, EL Fogel, S Sherman and GA Lehman. Indianapolis, I N

10:42

The basic helix loop helix t r a n s c r i p t i o n factor beta2 coordinates t e r m i n a l d i f f e r e n t i a t i o n of s e c r e t i n - p r o d u c i n g e n t e r o e n d o c r i n e cells. (Abstract# G3675) H Mutoh and AB Leiter. Boston, MA

10:56

Title TBA. Jorden Cohen. Washington, DC

11:16

A safety a n d efficacy s t u d y of r e c o m b i n a n t h u m a n i n t e r l e u k i n - 1 0 t r e a t m e n t i n 329 p a t i e n t s with c h r o n i c active C r o h n ' s disease. (Abstract# G4423) S Schreiber, RN Fedorak, OH Nielsen, G Wild, NC Williams, M Jacyna, BA Lashner, M Cohard, A Kilian, A Lebeaut, SB Hanauer and the Crohn's Disease IL-10 Cooperative Study Group. Berlin, Germany; Edmonton, Montreal and Halifax, Canada; Copenhagen, Denmark; Harrow, United Kingdom; Cleveland, OH; Kenilworth, NJ and Chicago, IL

11:30

U.K. MRC t r i a l of H. p34ori e r a d i c a t i o n t h e r a p y for n o n - u l c e r dyspepsia. (Abstract# G0908) KEL McColl, LS Murray, E E1-Omar, AW Kelman, A Dickson, A E1-Nujumi, A Wirz, R Knill-Jones, C Penney, K Cochrane, B Danesh, N Gaw and F Wilson. Glasgow, Scotland

11:44

A s t h m a a n d g a s t r o e s o p h a g e a l reflux: f u n d o p l i c a t i o n decreases n e e d for systemic corticosteroids. (Abstract# S0243) H Spivak, CD Smith, A Phichith, K Galloway, PJ Waring and JG Hunter. Atlanta, GA

April 1998

PROGRAM OF THE ANNUAL MEETING P61

MONDAY, MAY 18, 1998 MEET-THE-PROFESSOR/MEET-THE-INVESTIGATOR L U N C H E O N S 12:30 P M t o 1:45 P M

MEET-THE-INVESTIGATOR LUNCHEONS 1

Kim E. Barrett

2

Eugene B. Chang

3 4

Richard B, Lynn Juanita L. Merchant

Signal transductions mechanisms in epithelial transport function Intestinal epithelial pathobiology of inflamed mucosa Update on leptin: the new obesity gene hormone The molecular basis for Helicobacter pylori-related diseases MEET-THE-PROFESSOR

5

Paul Adams

6

Bruce R. Bacon

7 8 9

Peter A. Banks Thomas D, Boyer Lawrence J. Brandt

10

Michael Camilleri

11 12

Zane Cohen Adrian Di-Bisceglie

13

Joanne M. Donovan

14

Mark Feldman

15 16 17

18 19 20 21 22 23 24 25 26 27

John L. Gollan Fred S. Gorelick Renald A. Hinder Kenneth Devault William L. Hasler Anthony N. Kalloo Marshall M. Kaplan David A. Katzka Emmett B. Keeffe William M. Lee Bernard Levin Keith D. Lindor Karen L. Lindsay Alex G. Little

28

William C. Meyers

29 30 31 32 33

David M. Nagorney Theodore N. Pappas David A. Peura Henry A. Pitt Douglas K. Rex

34 35 36 37 38 39

Caroline A. Riely David B, Sachar Bruce D. Schirmer Douglas Simon Mitchell F. SorreU L. William Traverso

40

Theresa Wright

41 42 43 44

Suzanne Rose College Schmitt John F. Johanson Robert Chang Sanjiv Chopra

Crescent

Sheraton Sheraton

Edgewood Bonnie Burn

Sheraton

Ellendale

LUNCHEONS

Hemochromotosis: clinicalapplicationsof genetic testing Hemochromastosis gene and other news in hemochromatesis Advances in treatment of pancreatitis Cirrhotic ascites Diagnosis and management of ischemic bowel diseases Small bowel motility: what you really need to know Management of acute ulcerative colitis Pathogenesis and management of hepatecellular carcinoma The elusive gallstone: biliary pain and the negative ultrasound Acid base disorders in gastrointestinal disease: a simple approach Chronic hepatitis C: therapeutic approaches Cellular mechanisms of pancreatitis Selection and evaluation of patients for anti-reflux surgery The approach to the patient with nausea Sphincter of Oddi dysfunction Primary biliary cirrhosis Barrett's Esophagus Hepatitis C: who and how to treat Acute liver failure Update on pancreatic cancer Management of PBC and PSC Controversies in the treatment of hepatitis C Controversial role of surgery for Barrett's esophagus: is it dependent on the histologic appearance? Medical legal aspects of bile duct injury and other hepatobiliary procedures Metastatic cancer to the liver Management of biliary strictures H. pylori consensus or controversy Cholangiocarcinoma or benign biliary strictures Screening colonoscopy in average risk persons. Why? When? How often? Liver problems in pregnancy Common errors in the management of IBD Surgical treatment of obesity GI complicationsMarriott Care of the post-transplant liver patient Severe pancreatitis : when endo therapy? When surgery? New antivirals for hepatitis B AGA PROBLEM-BASED

Sheraton

LEARNING

Marriott

Bonaparte

Marriott Marriott Marriott

Regent Bacchus Audubon

Convention Center

Room 23

Convention Center Convention Center

Room 25 Room 27

Convention Center

Room 29

Convention Center

Room 31

Convention Center Marriott Convention Center

Room 26 Iberville Room 36

Convention Center Convention Center Sheraton Sheraton Sheraton Sheraton Sheraton Convention Center Sheraton Sheraton

Room 43 Room 44 St. Charles A St. Charles B Esterwood Evergreen Felicity Room 24 Oakley Resella

Sheraton

Southdown

Sheraton Sheraton Sheraton Sheraton Sheraton

Bayside A Suite 816 Suite 817 Suite 820 Suite 821

Sheraton Sheraton Sheraton Sheraton Marriott Marriott

Suite 824 Suite 825 Suite 828 Suite 829 Balcony I Balcony K

Marriott Marriott

Balcony N Balcony L

SESSIONS

Unusual case of Barrett's esophagus Marriott Measuring and managing outcomes in your practice Marriott

Bonaparte Regent

Financial aspects of practice management Hepatitis C: natural history and management

Bacchus Iberville

Marriott Marriott

P62 PROGRAMOFTHEANNUALMEETING [I

AGA

POSTER

GASTROENTEROLOGYVol. 1141No.4 SESSION

AGA Poster Session

8:00-5:00 p m

Hall D Ernest IV. Morial Convention Center

-- MONDAY,

MAY

18, 1998

Dyspepsia: prevalence, s u b g r o u p s a n d h e a l t h care seeking - a r a n d o m s u r v e y of 2300 households. (Abstract# G0197) JI Westbrook, NJ Talley and JH McIntosh. Sydney, Australia

Authors are required to present during the Poster Session from 12:00-2:30 pm

DDW Poster of Distinction:

Those posters identified as D D W Posters of Distinction have received review scores that place them within the top 10% of all posters. We encourage you to make them a priority as you visit the poster session.

N o n s t e r o i d a l a n t i i n f l a m m a t o r y d r u g use i n p a t i e n t s at high r i s k for adverse GI events: a m a n a g e d c a r e perspective. (Abstract# G0U4) MS Matusik, EM Pelletier and JL Goldstein. Deerfield and Chicago, IL; Waltham, MA

CLINICAL PRACTICE - I

DDW Poster of Distinction:

Medical or s u r g i c a l t h e r a p y for erosive reflux esophagitis: a cost-utility analysis. (Abstract# G0154) DC Sadowski, J Romagnuolo and M Meier. Edmonton, Canada

Utilization

I m p a c t of g a s t r o e s o p h a g e a l reflux s y m p t o m s on work a b s e n t e e i s m . (Abstract# G0190) C Valle, C Alvisi, F Broglia, E Strada, C Tinelli, A Pistorio and M Perego. Pavia, Italy G a s t r o e s o p h a g e a l reflux s y m p t o m s i n t h e c o m m u n i t y . (Abstract# G0088) T Kennedy and R Jones. London and Teeside, United Kingdom Overweight a n d o t h e r r i s k factors for h o s p i t a l i z a t i o n w i t h g a s t r o e s o p h a g e a l reflux disease. (Abstract# G0151) CE Ruhl and JE Everhart. Bethesda, MD

D D W Poster of Distinction: Outcome of reflux esophagitis i n p a t i e n t s w i t h a n d w i t h o u t f u n d o p l i c a t i o n . (Abstract# G0045) HB E1-Serag and A Sonnenberg. Albuquerque, NM

and

outcomes of office-based t e s t i n g for

Helicobacterpyloriin s y m p t o m a t i c p r i m a r y care patients. (Abstract# G0095) U Ladabaum, AM Fendrick and JM Scheiman. Ann Arbor, MI Does Helicobacter s t a t u s alone affect o u t c o m e of dyspeptic p a t i e n t s ? (Abstract# G0056) F Froehlich, C Schneider, JP Vader, B Burnand, V Wietlisbach, P Hildebrand, K Gyr, G Stalder, C Beglinger and JJ Gonvers. Lausanne and Basel, Switzerland

Hellcobacterpyloriinfection is a d e t e r m i n a n t of basal g a s t r i n levels i n p a t i e n t s w i t h c h r o n i c r e n a l failure. (Abstract# G0194) H Watanabe, H Hiraishi, M Ishida, A Terano and J Kazama. Tochigi and Niigata, Japan P e p s i n o g e n I/II r a t i o i n p a t i e n t s with c h r o n i c r e n a l failure: i n f l u e n c e of Helicobacter pylori infection. (Abstract# G0195) H Watanabe, H Hiraishi, K Kanke, O Suzuki, Y Suzuki, M Ishida, A Terano and J Kazama. Tochigi and Niigata, J a p a n

Successful t r e a t m e n t w i t h e r y t h r o m y c i n of n a u s e a , v o m i t i n g a n d a n o r e x i a following h e m a t o p o i e t i c stem cell t r a n s p l a n t a t i o n . (Abstract# G0018) RE Brand, JK DiBaise, SR Tarantolo, L Gobar, KS Harmon and EMM Quigley. Omaha, NE

A

Decrease i n i n t e r o b s e r v e r v a r i a b i l i t y w h e n a p p l y i n g the r e v i s e d S y d n e y Classification for gastritis after j o i n t r e v i e w of cases. (Abstract# GOO70) J Guarner, R Herrara, A Mohar, C Ley, L Sanchez, D Halperin and J Parsonnet. Atlanta, GA; Mexico City and San Cristobal de las Casas, Mexico; Stanford, CA

I m p l i c a t i o n s of the i n t r o d u c t i o n of the 13C-urea b r e a t h test to a r e m o t e area h e a l t h service. (Abstract# G0008) PA Bampt0n, R Fraser, R Butler, P Cmielewski and G Davidson. Broken Hill and Adelaide, Australia

Helicobacter test a n d t r e a t strategy: costs a n d outcomes i n a r a n d o m i s e d c o n t r o l l e d t r i a l i n p r i m a r y care. (Abstract# G008O) RH Jones, CL Tait, G Sladen and J Weston-Baker. London, United Kingdom

DDW Poster of Distinction:

" R e a s s u r a n c e cost" m a y affect estimates of r e s o u r c e u t i l i z a t i o n i n d y s p e p s i a if gastroscopy is i n s u f f i c i e n t to p r e v e n t f u r t h e r testing. (Abstract# G0155) AV Sahai, I Penman, D Williams, G Mishra, W Knapple, A vanVelse, RH Hawes and BJ Hoffman. Charleston, SC

A d h e r e n c e to guidelines for m a n a g i n g Helicobacter pyloriin p a t i e n t s h o s p i t a l i z e d with p e p t i c ulcers.

Does severe a t r o p h i c gastritis r e a l l y h a v e a high r i s k of gastric cancer? (Abstract# G0091) F Kitahara, K Kobayashi, T Sato, Y Kojima and MA Fujino. Yamanashi, Japan

DDW Poster of Distinction:

(Abstract# G0031) JA Culpepper-Morgan, ME Cohen and J Williams. Norwalk, New Haven and Middletown, CT

Outcomes d i s t r i b u t i o n s of peptic u l c e r disease from 1992 to 1996 i n the Medicare p o p u l a t i o n a n d the i m p a c t of processes of care. (Abstract# G0202) W Xu, H Hood, D Nicewander and C Wark. Birmingham, AL; Dallas, TX and Baltimore, MD

PROGRAM OF THE ANNUAL MEETING P63

April 1998

II

A G A P O S T E R S E S S I O N - - M O N D A Y , MAY 18, 1998

DDW Poster of Distinction: The q u a l i t y of care for Medicare beneficiaries with p e p t i c u l c e r disease - a m u l t i s t a t e q u a l i t y i m p r o v e m e n t project. (Abstract# G0129) J Ofman, W Alexander, C Cangielose, D Ballard and B Marshall. Los Angeles, CA; Aurora, CO; Atlanta, GA and Nedlands, Australia The economic i m p a c t of t h e diagnosis of dysplasia i n B a r r e t t ' s esophagus. (Abstract# G1007) J Ofman, K Lewin, A Ippoliti, D Lieberman and W Weinstein. Los Angeles, CA and Portland, OR Adverse e v e n t profile d u r i n g long t e r m t r e a t m e n t with omeprazole. (Abstract# G0193) A Walan, S Joelson and H Blom. G6teborg, Sweden Hospital u s e of p r o t o n p u m p i n h i b i t o r s : a complete a u d i t of t h e i n t r o d u c t i o n of a p r e s c r i b i n g protocol o n i n p a t i e n t p r e s c r i p t i o n s . (Abstract# G0124) M Newton, G Smith, WR Burnham, C Nicholls and B So. Romford, United Kingdom P a n t o p r a z o l e i n p a t i e n t s w i t h v a r y i n g degree of liver i m p a i r m e n t i n c o m p a r i s o n to h e a l t h y controls. (Abstract# G0019) HP Breuel, J Horak, M Horejsova, PR Heine, M Hartmann, R Huber, R LOhmann and W Wurst. Berlin and Constance, Germany; Prague, Czech Republic I n h i b i t i o n of p e n t a g a s t r i n - i n d u c e d gastric acid s e c r e t i o n b y i n t r a v e n o u s p a n t o p r a z o l e : a dose r a n g i n g study. (Abstract# G0138) JR Pisegua, CA Asvar, EA Lew, M Huang, P Martin, GV Ohning, T Kovacs, JH Walsh and J Paul. Los Angeles, CA and Philadelphia, PA A p h a r m a c o k i n e t i c s t u d y of the p o t e n t i a l d r u g i n t e r a c t i o n b e t w e e n oral p a n t o p r a z o l e a n d cisapride i n h e a l t h y adults. (Abstract# G0048) GM Ferron, J Paul, RJ Fruncillo, PT Martin, L Yacoub and PR Mayer. Radnor, PA P r e d i c t o r s of g a s t r o i n t e s t i n a l h e m o r r h a g e i n 893 p a t i e n t s w i t h b e n i g n - a p p e a r i n g gastric ulcers. (Abstract# GO015) EJ Bini, JS Unger and J Cohen. New York, NY P r e d i c t i v e v a l u e of h e m o r r h a g e for the diagnosis of occult m a l i g n a n c y i n p a t i e n t s with b e n i g n - a p p e a r i n g gastric ulcers. (Abstract# G0014) EJ Bini, JM Reiber and J Cohen. New York, NY Severe g a s t r o i n t e s t i n a l b l e e d i n g after m a r r o w t r a n s p l a n t a t i o n , 198%1997: incidence, causes a n d outcome. (Abstract# G0161) JM Schwartz, SI Strasser, S Otero Lopez-Cubero, CS Murakami, DM Hockenbery and GB McDonald. Seattle, WA P r o s p e c t i v e e v a l u a t i o n of o u t p a t i e n t m a n a g e m e n t of a c u t e g a s t r o i n t e s t i n a l h e m o r r h a g e . (Abstract# G0176) J Spears, R Fogel and T Ben-Menachem. Detroit, MI

DDW Poster of Distinction: Cost a n a l y s i s of a l t e r n a t i v e t h e r a p i e s for p r i m a r y a n d s e c o n d a r y p r o p h y l a x i s of variceal bleeding. (Abstract# G2415) GM Eisen, JM Inadomi and A Sonnenberg. Memphis, TN and Albuquerque, NM D e t e r m i n a n t s of case cost for n o n - v a r i c e a l u p p e r g a s t r o i n t e s t i n a l h e m o r r h a g e at a C a n a d i a n c o m m u n i t y hospital. (Abstract# G0112) JK Marshall, SM Collins and A Gafni. Hamilton, Canada

Case cost a n d r e s o u r c e u t i l i z a t i o n for b l e e d i n g peptic ulcers: t h e O n t a r i o GI b l e e d study. (Abstract# G01U) JK Marshall, SM Collins and A Gafni. Hamilton, Canada Study c o m p a r i n g Nd-YAG l a s e r a n d h e a t e r p r o b e efficacy o n c h r o n i c rectal b l e e d i n g of r a d i a t i o n colitis. (Abstract# G0U8) S Michopoulos, P Tsibouris, A Balta, M Economou, I Vougadiotis and N Kralios, Athens, Greece Risk of f r a c t u r e s i n celiac disease p a t i e n t s . A crosssectional, case-control study. (Abstract# G0191) H Vazquez, R Mazure, D F10res, S Pedreira, S Niveloni, E Smecuol, D Gonzalez, L Boerr, E Maurifio and JC Bai. Buenos Aires, Argentina Mortality i n celiac disease i n a M e d i t e r r a n e a n area. (Abstract# G0183) A Termini, M Cottone, L Oliva, A Magliocco, C Marrone, G Alabiso, F Pinzone and L Pagliaro. Palermo, Italy The i m p a c t of home p a r e n t e r a l n u t r i t i o n on q u a l i t y of life i n s h o r t bowel p a t i e n t s . (Abstract# GOO79) PB Jeppesen, E Langholz and PB Mortensen. Copenhagen, Denmark Late m o r b i d i t y a n d m o r t a l i t y i n 109 p a t i e n t s o p e r a t e d on for r a d i a t i o n enteritis. (Abstract# G0049) A Fingerhut, JL Gouzi, JM Hay and B Millat. Poissy, Toulouse, Colombes and Montpellier, France U n i n t e n t i o n a l weight loss is f r e q u e n t l y due to g a s t r o i n t e s t i n a l diseases. (Abstract# G0098) PG Lankisch, M Gerzmann and J-F Gerzmann. Lueneburg, Germany ESOPHAGEAL, GASTRIC, AND DUODENAL DISORDERS - - H E L I C O B A C T E R PYLORI: THERAPY

H. pylorl e r a d i c a t i o n t h e r a p y : a d i s c r e p a n c y b e t w e e n c u r r e n t g u i d e l i n e s a n d c l i n i c a l practice. (Abstract# G0812) JM Lee, D McNamara and CA O'Morain. Dublin, Ireland Factors affecting e r a d i c a t i o n of Helicobacterpyloriin p a t i e n t s from c o m m u n i t y g a s t r o e n t e r o l o g i c a l practice. (Abstract# G0664) BE Jones, M Weltman and C Liddle. Westmead, Australia

DDW Poster of Distinction: CYP2C19 g e n o t y p e s t a t u s a n d d u a l t h e r a p y w i t h omeprazole a n d amoxicillin for e r a d i c a t i o n of ttelicobacter pylori a n d p e p t i c u l c e r healing. (Abstract# G0520) T Furuta, K Ohashi, T Kamata, M Takashima, H Hanai, K Kosuge, T Kubota, T Ishizaki and E Kaneko. Hamamatsu and Tokyo, Japan E n h a n c e d effect for Helicobacterpylotd e r a d i c a t i o n was a c h i e v e d by u s i n g omeprazole, b u t n o t lansoprazole, i n cytochrome P450 2C19 poor metabolizers. (Abstract# G0233) N Aoyama, Tanigawara, T Kita, S Sakai, K Shirakawa, F Kodama, K Okumura and M Kasuga. Kobe, Japan

DDW Poster of Distinction: Susceptibility of a m o x i c i l l i n - r e s i s t a n t H. pylori to different ~-laetam antibiotics. (Abstract# G0448) MP Dote, MS Osato, SG Reddy, DY Graham and AR Selpuveda. Houston, TX

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A n t i b i o t i c r e s i s t a n t H. pylori are e x t r e m e l y c o m m o n i n S a r d i n i a . (Abstract# G0445) MP Dore, B Are, M Carta, I Mura, A Maida, G Realdi, AR Sepulveda and DY Graham. Sassari, Italy and Houston, TX A m e t a - a n a l y t i c a l a p p r o a c h to u n d e r s t a n d i n g the effect of m e t r o n i d a z o l e r e s i s t a n c e o n o u t c o m e of H. pylori t h e r a p y . (Abstract# G0444) MP Dote, G Realdi, DY Graham, AR Sepulveda and G Leandro. Sassari and Bari, Italy; Houston, TX A n i n c r e a s e i n a n t i b i o t i c - r e s i s t a n t Helicobacterpylori s t r a i n s after n e w t r i p l e t h e r a p y . (Abstract# G0778) T Kubota, R Sate, K Murakami, M Kimoto, T Fujioka and M Nasu. Oita, Japan

Helieobaeterpylori s u s c e p t i b i l i t y testing: c o m p a r i s o n of E-test a n d agar d i l u t i o n methods. (Abstract# G1025) MS Osato, RK Flamm and LJ Utrup. Houston, TX; Abbott Park, IL and Rockville, MD

DDW Poster of Distinction: C o m p a r a t i v e efficacies of a n t i m i c r o b i a l agents a g a i n s t c l a r i t h r o m y c i n - r e s i s t a n t Helieobaeter pylori. (Abstract# G1024) MS Osato, SG Reddy, DY Graham, AA Piergies, W Bochenek and R Testa. Houston, TX; Evanston, IL and Philadelphia, PA Different a n t i m i c r o b i a l p a t t e r n s of Itelicobaeterpylori isolated from the s t o m a c h corpus a n d a n t r u m . (Abstract# G0415) JM Devaster, A Burette, P Mandisodza, S Goutier, C Van den Borre, M Deltenre, S Cadranel and JP Butzler. Brussels, Belgium S u r v e y of the in vitro s u s c e p t i b i l i t y of Helicobaeter pyIori to a n t i b i o t i c s i n F r a n c e - p r e l i m i n a r y results. (Abstract# G0330) N Broutet, F Guillon, E Sauty, D Lethuaire and F M~graud. Bordeaux and Gentilly, France R a n d o m i z e d t r i a l of omeprazole a n d c l a r i t h r o m y c i n c o m b i n e d w i t h e i t h e r m e t r o n i d a z o l e or amoxicillin i n t h e t r e a t m e n t of Helieobaeterpyloriin m e t r o n i d a z o l e r e s i s t a n t or s e n s i t i v e p a t i e n t s . (Abstract# G0628) MHMG Houben, EF Hensen, BWM van 't Hoff, RWM van der Hulst, EAJ Rauws, A van der Ende, FJW ten Kate and GNJ Tytgat. Amsterdam, The Netherlands

DDW Poster of Distinction: Efficacy of colloidal b i s m u t h s u b c i t r a t e , m e t r o n i d a z o l e a n d t e t r a c y c l i n e HCl i n e r a d i c a t i o n of H. pylori. A r a n d o m i s e d , p l a c e b o - c o n t r o l l e d s t u d y . (Abstract# G1317) SV VanZanten, A Farley, N Marcon, R Lahaie, A Archambault, R Hunt, R Bailey, D Owen, J Sp~nard and P Colin. Halifax, Montreal, Toronto, Hamilton, Edmonton and Vancouver, Canada New s h o r t t e r m q u a d r u p l e t h e r a p i e s for e r a d i c a t i o n of Helleobaeterpylori- MACLOR study. (Abstract# G1277) G Treiber, J Wittig, S Amm0n, S Walker and U K10tz. Stuttgart, Germany One-week v e r s u s two-week b i s m u t h subsalicylate-based t r i p l e t h e r a p y for H. pylor~, r e s u l t s of a U.S. r a n d o m i z e d trial. (Abstract# G1388) R Yang, R Hamamot0 and L Laine. Los Angeles, CA

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Twice-daily 10-day t r i p l e t h e r a p y w i t h omeprazole, amoxicillin a n d c l a r i t h r o m y c i n for H. pylori e r a d i c a t i o n i n d u o d e n a l u l c e r disease: r e s u l t s of t h r e e m u l t i c e n t e r , double-blind, U.S. trials. (Abstract# G0794) L Laine, L Suchower, A Conners, J Frantz and G Neff. Los Angeles, CA and Wayne, PA Randomized controlled study comparing furazolidone versus metronidazole in quadruple therapy (ranitidine + b i s m u t h s u b c i t r a t e + amoxicillin) for Helicobacter pylori e r a d i c a t i o n i n DU p a t i e n t s . (Abstract# G0868) R Malekzadeh, R Ansari, H Vahedi, BZ Alizadeh and S Massarrat. Tehran, Iran R a n d o m i z e d c o n t r o l l e d t r i a l c o m p a r i n g two weeks modified q u a d r u p l e (Ome + Cbs + Tet + Cla) to two a n d t h r e e weeks r a n i t i d i n e + triple (Cbs + Tet + Met) t h e r a p y for H, pyIori e r a d i c a t i o n i n d u o d e n a l u l c e r patients. (Abstract# G0869) R Malekzadeh, R Sotudehmanesh, F Siavoshi, BZ Alizadeh, M Eshraghian and S Massarrat. Tehran, Iran Attempts to i m p r o v e c o m p l i a n c e w i t h Helicobacter pyloritriple t h e r a p y do n o t i m p r o v e outcome: the Help study. (Abstract# G0607) A Henry, R Batey, E Ianna, D Routley and D Vakil. Newcastle, Australia One week b i s m u t h + m e t r o n i d a z o l e + a m o x i c i l l i n (BMA) w i t h r a n i t i d i n e (Ran) versus two weeks BMA w i t h o u t R a n versus two weeks BMA ÷ R a n for HP e r a d i c a t i o n : a r a n d o m i z e d s i n g l e - b l i n dcontrolled study. (Abstract# G0698) MJ Kaviani, R Malekzadeh, H Vahedi, M Zare, M Kamalian, M Sotudeh and S Massarrat. Tehran, Iran cag negative s t a t u s of Helicobacterpylord is a r i s k factor for f a i l u r e of P P I - b a s e d t r i p l e t h e r a p i e s i n n o n u l c e r dyspepsia. (Abstract# G0878) A Marais, L Monteiro, H Lam0uliatte, R Sam0yeau and F M~graud. Bordeaux and La M~e sur Seine, France F a i l u r e of Bazzoli's r e g i m e n (omeprazolem e t r o n i d a z o l e - c l a r i t h r o m y c i n ) t h e r a p y for H. pylord infection i n S a r d i n i a . (Abstract# G1091) G Realdi, MP Dore, M Carta, A Atzei, A Manca, A Piana, M Idda, B Are, G Massarelli, ! Mura, A Maida, AR Sepulveda and DY Graham. Sassari, Italy and Houston, TX New t h e r a p y for H. pylori: omeprazole-metronidazolet e t r a c y c l i n e a n d the effect of t e t r a c y c l i n e r e s i s t a n c e . (Abstract# G1092) G Realdi, MP Dore, A Atzei, M Carta, A Piana, A Manca, L Cugia, B Are, G Massarelli, I Mura and A Maida. Sassari, Italy The efficacy of two dosage r e g i m e n s of omeprazole, amoxicillin a n d m e t r o n i d a z o l e for cure of Helieobacter pylori infection - the HERA study. (Abstract# G0277) E Bayerd6rffer, J Lonovics, P Dit~, U Diete, L D0mj~in, I Kisfalvi, F M6graud, A Pap, P Sipponen, C-F Burman and L Zeijlon. Dresden, Germany Effectiveness of omeprazole, amoxicillin, a n d c l a r i t h r o m y c i n i n e r a d i c a t i n g Hellcobacter pylori i n p a t i e n t s o n c h r o n i c acid s u p p r e s s i o n for p e p t i c u l c e r disease or ulcer-like symptoms. (Abstract# G0220) J Allison, R Hiatt, T Levin, T Lieu, L Ackerson, L Hurley and D Libran. Oakland, CA

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One-week t h e r a p y w i t h omeprazole or r a n i t i d i n e b i s m u t h c i t r a t e a n d two a n t i b i o t i c s for e r a d i c a t i o n of Helieobaeterpyloriin d u o d e n a l ulcer: a p r e l i m i n a r y r e p o r t . (Abstract# G1204) GC Spinzi, A Bortoli, A Corbellini, E Colombo, GL Lanzi and G Minoli. Como and Milan, Italy F a c t o r s affecting c o m m u n i t y Helleobacterpylori e r a d i c a t i o n for p e p t i c u l c e r a t i o n . (Abstract# G0504) EH Forrest, J Granger, S Ticcioni, L Murray, E Graham, JF MacKenzie, R Stuart and AJ Morris. Glasgow, Scotland G a l e n i c f o r m u l a t i o n s a n d Helieobacterpylori e r a d i c a t i o n . (Abstract# G0889) C Martin-de-Argila, D Boixeda, V Faro, JP Gisbert, L Moreno and AG Plaza. Madrid, Spain E r a d i c a t i o n r a t e of Helieobacterpyloriusing one week of omeprazole, c l a r i t h r o m y c i n a n d amoxicillin i n Chiapas, Mexico. (Abstract# G0831) C Ley, A Mohar, J Guarner, D Halperin, R Herrera, L Sanchez and J Parsonnet. Stanford, CA; Mexico City and San Cristobal de las Casas, Mexico Efficacy of l a n s o p r a z o l e i n a s s o c i a t i o n with c l a r i t h r o m i c y n a n d m e t r o n i d a z o l e or amoxycillin for H. pylori e r a d i c a t i o n . (Abstract# G0281) F Bazzoli, RM Zagari, P Pozzato, S Fossi, L Ricciardiello, G Nicolini, D Berretti, L de Luca, G Alampi and E Roda. Bologna, Italy Different l a n s o p r a z o l e dosages i n H. pylori e r a d i c a t i o n therapy: a prospective multicenter randomized study c o m p a r i n g 30 m g B.LD. v e r s u s 15 m g B.I.D. (Abstract# G0424) F Di Mario, A Buda, N Dal Bb, R De Bastiani, SA Grassi, B Crestani, G Battaglia, A Pflotto, M Franceschi, M De Bona and S Salandin. Padua, Bassano and Vicenza, Italy Short t e r m t r i p l e t h e r a p y w i t h l a n s o p r a z o l e 15 mg b.i.d. v e r s u s 30 m g b.i.d., a m o x i c i l l i n a n d c l a r i t h r o m y c i n for e r a d i c a t i o n of Helieobaeterpylori. (Abstract# Gl184) A Sieg, M Sellinger, D Schlauch and M HSrner. 0stringen, Ludwigshafen and Walldorf, Germany

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A single-blind m o n o c e n t r i c s t u d y of f o u r t r e a t m e n t s for H. pylori e r a d i c a t i o n : a n i n t e r i m r e p o r t . (Abstract# G1039) P Paoluzi, P Rossi, A Consolazio, OA Paoluzi, A Pietroiusti, F Maggio and M Iacucci. Rome, Italy E r a d i c a t i o n of H. pylori w i t h lansoprazole, r o x i t h r o m y c i n , a n d m e t r o n i d a z o l e - a n open pilot study. (Abstract# G1067) T Pohle, R Stall, T Kirchner, N Lehn, M Heep, H Bock and W Domschke. Munster, Erlangen, Regensburg and Frankfurt, Germany C o m p a r i s o n of t h r e e seven days p a n t o p r a z o l e - b a s e d Helicobacter pylori (Hp) e r a d i c a t i o n schemes i n a Mexican p o p u l a t i o n w i t h h i g h l y m e t r o n i d a z o l e r e s i s t a n t Hp s t r a i n s . (Abstract# G0405) M Dehesa, J Larisch, M Di Silvio, M Dibildox, I Almaguer, G Gonzalez, EJ Ramirez-Barba and J Tortes. Guamajuato and Naucalpan, Mexico P a n t o p r a z o l e - b a s e d t r i p l e t h e r a p y for H. pylori eradication: a c o m p a r i s o n of p a n t o p r a z o l e once versus twice daily. (Abstract# G0265) KD Bardhan, J Dillon, ATR Axon, BT Cooper, G Tildesley, A Truckel, K Culshaw and A Perkins. Rotherham, United Kingdom

H. pyIori e r a d i c a t i o n w i t h omeprazole, m c t r o n i d a z o l e a n d amoxicillin: the i m p a c t of d r u g d o s i n g a n d r e s i s t a n c e o n efficacy - the HOMER story. (Abstract# G0264) KD Bardhan, E Bayerd6rffer, J-P Delchier, M Hellblom, F M~graud, A Stubber6d, SJOV van Zanten, T Lind, CF Burman and P-O Gromark. Rotherham, United Kingdom; Canada, France, Germany and Sweden R a n i t i d i n e b i s m u t h c i t r a t e w i t h c l a r i t h r o m y c i n given alone or with m e t r o n i d a z o l e for 7 days effectively eradicates H. pylori. (Abstract# G0266) KD Bardhan, D Morton, MJ Perry, PJA Willemse, P Morris, A Rowland, M Thompson, TR Mitchell and PM Roberts. Rotherham and Greenford, United Kingdom

E v a l u a t i o n of two doses of c l a r i t h r o m y c i n w i t h m e t r o n i d a z o l e a n d l a n s o p r a z o l e for seven days i n e r a d i c a t i o n of H. pylori. (Abstract# G0357) C Charles, M Sue, T Wyatt, H Reid, E Morris, B Marshall and D Peura. Turkeyen, Guyana and Charlottesville, VA

Ranitidine bismuth citrate with metronidazole and t e t r a c y c l i n e is a n effective a n d i n e x p e n s i v e t r e a t m e n t for the e r a d i c a t i o n of H. pylori. (Abstract# G0267) KD Bardhan, D Morton, MJ Perry, PJA Willemse, P Morris, A Rowland, M Thompson and PM Roberts. Rotherham and Greenford, United Kingdom

C o m p a r i s o n of two one-week t r i p l e t h e r a p i e s with low dose of l a n s o p r a z o l e a n d two low dose antibiotics i n Helleobacterpylori e r a d i c a t i o n . A F r e n c h study. (Abstract# G0796) H Lamouliatte, the Aquitaine Gastro Association, F M6graud, S Forestier and M Laurence. Bordeaux and Puteaux, France

Efficacy of six days triple t h e r a p y w i t h p a n t o p r a z o l e plus c l a r i t h r o m y c i n a n d a m o x i c i l l i n v e r s u s omeprazole plus c l a r i t h r o m y c i n a n d a m o x i c i l l i n for H. pylord eradication. (Abstract# G0438) A Dominguez-Martin, A Dominguez-Mufioz, S Mufioz, JB Alonso and MD Gonzfilez. Malaga, Spain

HeIicobaeterpylori e r a d i c a t i o n w i t h a one-week triple t h e r a p y . Meta-analysis of F r e n c h studies. (Abstract# G0797) H Lamouliatte and R Cayla. Bordeaux, France Three-days a n d seven-days t r i p l e t h e r a p y w i t h c l a r i t h r o m y c i n or a z i t h r o m y c i n for cure of H. pylorl infection. (Abstract# G1063) O Pieramico, MV Zanetti and M Innerhofer. Merano, Italy High-dosage omeprazole-based t r i p l e t h e r a p y for the e r a d i c a t i o n of H. pylorl infection: a r a n d o m i z e d trial. (Abstract# G1062) O Pieramico, MV Zanetti and M Innerhofer. Merano, Italy

Efficacy a n d t o l e r a b i l i t y of a p a n t o p r a z o l e - b a s e d triple t h e r a p y for c u r e of Hclieohaeterpyloriinfection i n p a t i e n t s w i t h d u o d e n a l ulcer. (Abstract# G1048) P Pazzi, R Scagliarini, V Matarese, S Gamberini, C Rizzo and S Gullini. Ferrara, Italy P a n t o p r a z o l e , amoxycillin a n d m e t r o n i d a z o l e i n Helicobacterpylori-positive d u o d e n a l u l c e r p a t i e n t s : effects o n symptoms, u l c e r h e a l i n g a n d e r a d i c a t i o n rates. (Abstract# G1064) A Pilotto, M Franceschi, L Bierti, R Di Battista, G Leandro, A Notarbartolo, G Pisciotta, A Grassi, G Tafner, S Michelagnoli and F Garotta. Milan, Palermo, Bassano and Trent, Italy

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GASTROENTEROLOGYCol. 114~No. 4

A G A P O S T E R S E S S I O N u M O N D A Y , MAY 18, 1998

DDW Poster of Distinction: P r o s p e c t i v e r a n d o m i z e d c o m p a r i s o n of 1-week RBCt r i p l e t h e r a p y v e r s u s 1-week P P I - t r i p l e t h e r a p y for H. pylori-related d u o d e n a l ulcers. (Abstract# G1216) JY Sung, WK Leung, TKW Ling, MY Yung, KL Chan, YT Lee, SCS Chung and AFB Cheng. Hong Kong, China A m u l t i c e n t e r r a n d o m i z e d t r i a l w i t h twice daily ranitidine bismuth-citrate, metronidazole and t e t r a c y c l i n e for 7 or 10 days for e r a d i c a t i o n of H. pj~lori infection. (Abstract# G0736) K Knigge, C Kelly, MB Fennerty and WL Peterson. Portland, OR and Dallas, TX Ranitidine bismuth citrate with clarithromycin given for 7 days effectively e r a d i c a t e s / / , pylor/. (Abstract# G1267) B Thjodleifsson, JA Beker, F Costa Mira, A Farley, TR Mitchell and PM Roberts. Reykjavik, Iceland; Leidschendam, The Netherlands; Lisbon, Portugal; Montreal, Canada and Greenford, United Kingdom R a n i t i d i n e b i s m u t h citrate, tetracycline, c l a r i t h r o m y c i n : a twice-a-day t r i p l e therapy. (Abstract# G0567) DY Graham, J Hoffman, MS Osate and HMT E1-Zimaity. Houston, TX New t h e r a p y for m e t r o n i d a z o l e or c l a r i t h r o m y c i n r e s i s t a n t Hellcobacterpylo~. FOC or FOM. (Abstract# G0566) DY Graham, J Hoffman, MS Osato and HMT E1-Zimaity. Houston, TX B S S q u a d r u p l e "salvage" t h e r a p y for p a t i e n t s with c u l t u r e p r o v e n m e t r o n i d a z o l e - r e s i s t a n t Helicobacter pylori. (Abstract# G0563) DY Graham, J Hoffman, MS Osato and HMT El-Zimaity. Houston, TX

Large U.S. clinical t r i a l s r e p o r t a h i g h p r o p o r t i o n of H. pylori-negative d u o d e n a l ulcers at s t u d y e n t r y as well as a h i g h r e c u r r e n c e r a t e after cure of the infection: have we all b e e n w r o n g ? (Abstract# G0068) DY Graham. Houston, TX R a n i t i d i n e b i s m u t h c i t r a t e w i t h low dose c l a r i t h r o m y c i n a n d m e t r o n i d a z o l e for one week gives high r a t e s of H. pylori e r a d i c a t i o n . (Abstract# G1349) S Wetterhus, D Boixeda, I Altorjay, R Federico, S Vanweerts and AE Duggan. Kongsvinger, Norway; Madrid, Spain; Debrecen, Hungary; Rosanno Calabro Scalo, Italy; United Kingdom T e n day triple t h e r a p y w i t h r a n i t i d i n e b i s m u t h citrate, amoxicillin a n d c l a r i t h r o m y c i n i n the e r a d i c a t i o n of H. pylori. (Abstract# G1297) N Vakil and AF Cutler. Milwaukee, WI and Detroit, MI T w o open-label efficacy t r i a l s of r a n i t i d i n e b i s m u t h citrate in combination with clarithromycin and amoxicillin or m e t r o n i d a z o l e for ttelicobacterpylori eradication. (Abstract# G0388) JA Crawford, JM Meyer, R Herm-Barabasz and JL Goldstein. Chicago, IL

Ranitidine bismuth citrate plus clarithromycin and m e t r o n i d a z o l e i n a g e o g r a p h i c a l a r e a w i t h high p r i m a r y m e t r o n i d a z o l e r e s i s t a n c e . (Abstract# G1055) F Perri, V Festa, R Clemente, M Quitadamo, G Niro and A Andrinlli. San Giovanni Rotondo, Italy R a n d o m i z e d c o m p a r i s o n of amoxicillin]tetracyclinebased triple t h e r a p i e s for H. pylorl. (Abstract# GI054) F Perri, R Clemente, V Festa, M Quitadamo and A Andriulli. San Giovanni Rotondo, Italy

Effectiveness of a r a n i t i d i n e b i s m u t h c i t r a t e t r i p l e t h e r a p y for t r e a t i n g tlelicobacterpTlori. (Abstract# GU89) DT Smoot, T Hinds, H Ashktorab, J Jagtap and KS Kim. Washington, DC A c o m p a r i s o n of t h r e e 7-day t r i p l e r e g i m e n s i n the e r a d i c a t i o n of Helioobacterpyloriinfection. P r e l i m i n a r y results. (Abstract# Gl142) V Savarino, G Bisso, M Pivari, C Bilardi, MR Mele, A Costa, GS Mela, P Zentflin, C Mansi, P Borro, G Borgonovo, L De Salvo, S Vigneri and G Celle. Genoa and Palermo, Italy Triple t h e r a p y w i t h low versus h i g h dose a z i t h r o m y c i n to t r e a t H. pyloriinfection. (Abstract# G0370) WD Chey, L Fisher, J Barnett, J Delvalle, GH Elta, T Nostrant, J Palaniappan and J Scheiman. Ann Arbor, MI

Helicobacterpyzlori e r a d i c a t i o n t h e r a p y : t h r e e different one week r e g i m e n s comparison. (Abstract# G1089) M Ravizza, F Cappelletti, F Puglisi, U Giacobbe, E Gay, R Suriani, D Mazzucco and P Dusio. Turin, Italy

DDW Poster of Distinction: Metrouldazole r e s i s t a n c e does n o t i n f l u e n c e the efficacy of triple t h e r a p y w i t h r a n i t i d i n e b i s m u t h citrate, c l a r i t h r o m y c i n a n d m e t r o n i d a z o l e f o r / / , pylori infection. (Abstract# G1321) EJ vd Wouden, JC Thijs, AA van Zwet, A Kooy and JH Kleibeuker. Hoogeveen and Groningen, The Netherlands Towards m o n o t h e r a p y for HelicobacterpjTlori infection: first r e s u l t s with a single t r i p l e capsule. (Abstract# G0402) WA de Boer and TJ Borody. Oss, The Netherlands and Sydney, Australia C o m p a r i s o n of 2 t h r e e - d a y Helicobacterp~lori e r a d i c a t i o n r e g i m e n s with a s t a n d a r d one week r e g i m e n : a r a n d o m i z e d , i n v e s t i g a t o r - b l i n d study. (Abstract# G0573) CE Grimley, A Penny, M O'Sullivan, M Shebani, JR Lismore, R Cross, RC Illing, DE Loft and CU Nwokolo. Coventry, United Kingdom S t u d y o n the effect of a n e w a n t i - u l c e r agent, ecabet sodium, o n the d u a l t h e r a p y for e r a d i c a t i o n of tteHcobaeter pylorlin r a n d o m i z e d p a t i e n t s . (Abstract# G0672) H Kagaya, M Kato, T Kobayashi, J Ishizuka, K Nishikawa, Y Komatsu, M Sukegawa, H Takeda, T Sugiyama and M Asaka. Sapporo, Japan Polaprezinc, a m u c o s a l protective agent, i n c o m b i n a t i o n with lansoprazole, amoxicfllin a n d c l a r i t h r o m y c i n increases the e r a d i c a t i o n r a t e of Helicobacterpylor/infection. (Abstract# G0687) H Kashimura, K Suzuki, M Hassan, K Ikezawa, T Sawahata, T Watanabe, A Nakahara, H Mutoh and N Tanaka. Ibaraki, Japan A n e w q u a d r u p l e t h e r a p y w i t h omeprazole, amoxicillin, c l a r i t h r o m y c i n a n d ecabet s o d i u m for e r a d i c a t i o n of Hel/cobacterp~lori. (Abstract# G0519) T Furuta, T Kamata, M Takashima, H Hanai and E Kaneko. Hamamatsu, Japan

PROGRAMOF THEANNUALMEETINGP67

A G A P O S T E R S E S S I O N - - M O N D A Y , MAY 18, 1998 DDW Poster of Distinction: A z i t h r o m y c i n , f u r a z o l i d o n e a n d omeprazol: a p r o m i s i n g , low-dose, low-cost, short term, anti-//, pylori t r i p l e t h e r a p y . (Abstract# G0382) LGV Coelho, WLS Vieira, MCF Passos, Y Chausson, FJ Castro, JMM Franco, LD Moretzsohn, FR Yazaki, ACT Costa, JM Andrade and LP Castro. Belo Horizonte, Brazil Efficacy of s u c r a l f a t e s u s p e n s i o n s i n the e r a d i c a t i o n of Helleobacterpylo~. (Abstract# G1386) A Yanaka, H Suzuki, M Muto, T Shibahara, Y Murata, H Matsui, H Yokota, A Nakahara and H Muto. Ibaraki, Japan F a v o r a b l e effect of LC-1 y o g h u r t o n Hcllcobacter pylori gastritis i n m a n . (Abstract# G0491) CP Felley, JL Blanco Rivero, P Sipponen, D Kaufmann, P Bauerfeind, D Brassard, A Pfeifer, FE Maly, I Corth6syTheulaz, AL Blum and P Michetti. Lausanne and Zfirich, Switzerland; Jorvi, Finland P h o t o s e n s i t i v i t y of Helicobacter pylori a g a i n s t h a l o g e n light. (Abstract# G0623) S Honda, T Fujioka, H Mizoguchi, M Kimoto, K Arita and M Nasu. Oita, Japan Is t h e r e a role for h o n e y i n the t r e a t m e n t of Hclicobaeter pylorl i n f e c t i o n ? (Abstract# G1023) M Osato, S Reddy and DY Graham. Houston, TX Short t e r m t r i p l e r e g i m e for e r a d i c a t i o n of H. pylori with r o x i t h r o m y c i n . (Abstract# G0311) H Bock and H Mares. Frankfurt, Germany

In vitro a c t i v i t y of FR193879, a novel anti-Hellcobavter pylori c e p h a l o s p o r i n . (Abstract# G0903) Y Matsumoto, S Matsumoto, F Ikeda, A Ikemoto, C Morinaga, S Tawara, Y Yoshida, H Sasaki, K Matsuda, K Kawahata, H Takasugi and H Tanaka. Osaka, Japan T r e a t m e n t of Helleobaeterpyloriinfection i n r h e s u s m o n k e y s u s i n g a n o v e l a n t i a d h e s i o n compound. (Abstract# G0974) J Mysore, P Simon, D Zopf and A Dubois. Bethesda, MD and Horsham, PA Efficacy of two different dosages of n i z a t i d i n e i n c o m b i n a t i o n w i t h c l a r i t h r o m y c i n a n d amoxicillin i n H. pylorieradication. (Abstract# G0206) M Abdo, F Bernal, F Bosques, R Pifiero, A Altamirano, G Aristi, J Vaquez-Mellado and E Meofio. Mexico City, Mexico and Caracas, Venezuela A t h e r a p e u t i c s t r a t e g y after a first ineffective cure of H.

pylorlinfection. O n e - c e n t r e experience o n 74 c o n s e c u t i v e p a t i e n t s . (Abstract# G0274) G Battaglia, F Di Mario, ME Benvenuti, M Pasini, N Dal Bb, S Salandin, PM Dionisi, V Stracca-Pansa, M Pasquino and S Vigneri. Padua, Venice and Palermo, Italy A t h r e e y e a r follow-up s t u d y i n p a t i e n t s w i t h

endoscopically p r o v e n h e a l e d peptic u l c e r a n d e r a d i c a t e d H. pylor£ (Abstract# G0397) H-G Dammann, UR F61sch, T Kirchner, EG Hahn, DH v Kleist, H-U K16r and M Kist. Hamburg, Kiel, Erlangen, Berlin, Giessen and Freiburg, Germany Two-year follow-up of p a t i e n t s w i t h d u o d e n a l u l c e r after t r e a t m e n t w i t h omeprazole a n d amoxycillin]placebo. (Abstract# G0838) G Lindberg, R Befrits, B (~dman, S Sj6stedt, H S6rng~rd and the Stockholm United Study Group for Helicobacter Infection. Huddinge, Karolinska and Stockholm, Sweden

Long t e r m o u t c o m e of Hellcobaeterpyloriinfection after e r a d i c a t i o n i n F r a n c e . (Abstract# G0326) JF Bretagne, P Barth~l~my, A Caekaert and Hepysode. Rennes and Rueil-Malmaison, France The course of s y m p t o m s after e r a d i c a t i o n of Helicobaeterpj4or~. a one-year follow-up of a cohort of 258 p a t i e n t s w i t h d u o d e n a l u l c e r or n o n - u l c e r dyspepsia. (Abstract# G0327) JF Bretagne, A Caekaert, P Barth~l~my and Hepysode. Rennes and Rueil-Malmaison, France

DDW Poster of Distinction: Short t e r m a n d l o n g t e r m effect of n e w triple t h e r a p y i n Helicobacter-related u l c e r b l e e d i n g with m a j o r s t i g m a t a of r e c e n t h e m o r r h a g e . (Abstract# G0362) CY Chen, MZ Sheu and SC Lee. Chia-Yi, Taiwan I n t r a v e n o u s anti-Helicobacter t h e r a p y i n Helicobacterpositive b l e e d i n g p e p t i c u l c e r w i t h m a j o r s t i g m a t a of r e c e n t h e m o r r h a g e - a p r e l i m i n a r y report. (Abstract# G0361) CY Chen, MZ Sheu and SC Lee. Chia-Yi, Taiwan

DDW Poster of Distinction: R e c u r r e n c e of peptic u l c e r after successful e r a d i c a t i o n of Helicobaeterpyloriinfection i n J a p a n e s e p o p u l a t i o n : a prospective follow-up study. (Abstract# G0998) K Nishikawa, M Kato, T Kudo, Y Komatsu, F Sato, M Katagiri, T Kobayashi, M Sukegawa, H Kagaya, T Sugiyama and M Asaka. Sapporo, Japan

DDW Poster of Distinction: E r a d i c a t i o n of H. pylori or long t e r m acid s u p p r e s s i o n i n d u o d e n a l ulcer: a double-blind, r a n d o m i z e d t r i a l w i t h a two-year follow-up. (Abstract# G0336) P Bytzer. Odense, Glostrup, Holstebro, Sundby, Herning, Frederiksberg, Hj~rring, Kege, Bispebjerg, Hvidovre, Holb~ek, Scnderborg, Aalborg and Hillercd, Denmark The "second strike" concept of p r o t o n p u m p i n h i b i t i o n : closely spaced omeprazole a d m i n i s t r a t i o n i n H. pylori infection. (Abstract# G1038) D Pantoflickova, J Martinek, AL Blum, C Cederberg, M Stolte and P Wiesel. Lausanne, Switzerland; Hassle, Sweden and Bayreuth, Germany The effect of omeprazole o n i n t r a g a s t r i c pH a n d g a s t r i n levels is d e t e r m i n e d b y the CYP2C19 p o l y m o r p h i s m more t h a n b y H. pyloriinfection i n p a t i e n t s w i t h acidr e l a t e d disease. (Abstract# GU22) M Sagar, G Tybring, M-L Dahl, L Bertflsson and R Seensalu. Stockholm, Sweden The gastric t r a n s i t i o n a l zones a r e the areas w h e r e Helicobactcr t r e a t m e n t fails. R e s u l t s of a t r e a t m e n t t r i a l u s i n g t h e S y d n e y s t r a i n . (Abstract# G1323) S Veldhuyzen van Zanten, V Leung, J O'Rourke and A Lee. Halifax, Canada; Hong Kong, China and Sydney, Australia I m m u n i z a t i o n of mice w i t h Helicobactcrpylori urease, delivered m u c o s a l l y b y a n a t t e n u a t e d S. typhlmurium strain, r e s u l t s i n t h e u r e a s e specific i n d u c t i o n of b o t h a TH1 a n d a TH2 type i m m u n e response. (Abstract# G0385) IE C0rth~sy-Theulaz, S Hopkins, N Porta, D Bachmann, AL Blum and J-P Kraehenbuhl. Lausanne and Epalinges, Switzerland Mucosal i m m u n i z a t i o n with r e c o m b i n a n t homologous or heterologous u r e a s e p r e v e n t s H. h e i l m ~ i i infection i n mice. (Abstract# G0420) C Dieterich, H Bouzour~ne, AL Blum and IE Corth~syTheulaz. Lausanne, Switzerland

P68 PROGRAMOF THEANNUALMEETING

AGA

POSTER

GASTROENTEROLOGYVol.114~No. 4

,,

SESSION m MONDAY,

D D W Poster of Distinction: ~ Symptoms of g a s t r o e s o p h a g e a l reflux i n d u o d e n a l u l c e r p a t i e n t s after t r e a t m e n t for Helicobacterpylori d u r i n g a two-year follow-up. (Abstract# G1005) B Odman, G Lindberg, R Befrits, S Sj6stedt, H SSrng~rd and the Stockholm United Study Group for Helicobacter Infection. Huddinge, Karolinska and Stockholm, Sweden How c o m m o n is esophagitis after e r a d i c a t i o n of H.

pyloriinfection? (Abstract# G0876) GJ Mantzaris, E Archavlis, D Kourtessas, P Chistoforidis, K Petraki and G Triantafyllou. Athens, Greece Is t h e a c t i v i t y a n d s e v e r i t y of gastritis a n d Helicobactcr pyloriload r e l a t e d to t h e outcome of anti-H, pylori t r e a t m e n t ? (Abstract# G0877) GJ Mantzaris, E Archavlis, P Amberiadis, D Kourtessas, K Petraki and G Triantafyllou. Athens, Greece Is Helicobacter pylori e r a d i c a t i o n asssociated with the endoscopic d e v e l o p m e n t of esophagitis? (Abstract# G0509) G Friedman, CA Fallone, S Mayrand and AN Barkun. Montreal, Canada R e g r e s s i o n of a u t o i m m u n e t h r o m b o c y t o p e n i c p u r p u r a after HellcobacterpylorJ e r a d i c a t i o n . (Abstract# G0508) F Franceschi, A Gasbarrini, R Tartaglione, BM Ricerca, S Storti, V Ojetti, A De Luca, M Candelli, G Cammarota, R Landolfi, P Pola, G Leone and G Gasbarrini. Rome and Bologna, Italy

ttelicobacterpylori e r a d i c a t i o n a m e l i o r a t e s idiopathic

MAY

18, 1998

INTESTINAL DISORDERS - - CLINICAL

D D W Poster of Distinction: S e r u m a u t o a n t i b o d i e s to tissue t r a n s g l u t a m i n a s e for d e t e c t i o n of celiac disease. (Abstract# G1693) D Schuppan, W Dieterich, E Laag, H Sch6pper, U Volta, A Ferguson, H Gillet and EO Riecken. Erlangen and Berlin, Germany; Bologna, Italy and Edingburgh, United Kingdom R e d u c e d expression of E - c a d h e r i n i n t h e s m a l l i n t e s t i n a l mucosa of u n t r e a t e d celiac disease. (Abstract# G1651) I Perry, J Jankowski, BT Cooper and TH Iqbal. Birmingham, United Kingdom P e r m e a t i o n of i n t a c t sucrose i n h e a l t h y v o l u n t e e r s : dose response, time course i n s e r u m a n d recovery i n u r i n e . (Abstract# G1650) I Perry, KO Lewis, TH Iqbal and BT Cooper. Birmingham, United Kingdom B i s m u t h subsalicylate m a r k e d l y decreases h y d r o g e n sulfide release i n t h e h u m a n colon. (Abstract# G1712) FL Suarez, JK Furne, JR Springfield and MD Levitt. Minneapolis, MN P a n c r e a t i c s u p p l e m e n t s r e d u c e the s y m p t o m a t i c r e s p o n s e of h e a l t h y subjects to a h i g h fat meal. (Abstract# G1713) FL Suarez, MD Levitt, J Adshead and JS Barkin. Minneapolis, MN and Miami, FL

c h r o n i c u r t i c a r i a . (Abstract# G0529) A Gasbarrini, F Franceschi, C Di Campli, E Nucera, D Schiavino, V Ojetti, A De Luca, M Candelli, E Sanz Torre, M GabrieUi, I Massari, P Pola, G Patriarca and G Gasbarrini. Rome and Bologna, Italy

S o d i u m - h y d r o g e n e x c h a n g e r isoform 3 is n o t expressed i n the j e j u n a l m u c o s a of two p a t i e n t s w i t h m i c r o v i l l u s i n c l u s i o n disease. (Abstract# G1625) S Michail, JF Collins, H Xu, S Kaufman, J Vanderhoof and FK Ghishan. Tucson, AZ and Omaha, NE

Benefical effects of Helicobacterpylori e r a d i c a t i o n o n m i g r a i n e . (Abstract# G0528) A Gasbarrini, A De Luca, G Fiore, M Gabrielli, F Franceschi, V Ojetti, E Sanz Torte, M Candeili, I Massari, P Pola, M Giacovazzo and G Gasbarrini. Rome and Bologna, Italy

Are collagenous a n d lymphocytic colitis one disease? A histologic analysis of 178 cases. (Abstract# G1768) K Wouters, F Baert, C Sempoux, W Tanghe, M Marichal, C Cuvelier, P Rutgeerts, N Ectors, K Geboes and the Belgian IBD Group. Leuven, Belgium

HclJcobacterpylorJ i n f e c t i o n i n p a t i e n t s affected b y R a y n a u d p h e n o m e n o n : beneficial effects of eradication. (Abstract# G0530) A Gasbarrini, I Massari, M Serricchio, P Tondi, A De Luca, V Ojetti, F Franceschi, G Gasbarrini and P Pola. Rome and Bologna, Italy

P e r s i s t e n t measles v i r u s i n f e c t i o n a n d i m m u n o d e f i c i e n c y i n c h i l d r e n w i t h a u t i s m , ileo-colonic l y m p h o n o d u l a r h y p e r p l a s i a a n d non-specific colitis. (Abstract# G1755) AJ Wakefield, A Anthony, S Schepelmann, H Kawashima, R Sim, K Khan, SH Murch, AP Dhillon, AP Montgomery, MA Thomson, J Thomas and JA Walker-Smith. London, United Kingdom and Tokyo, Japan

I n s u l i n - d e p e n d e n t d i a b e t e s m e l l i t u s affects e r a d i c a t i o n r a t e of Hclicobacterpyloriinfection. (Abstract# G0532) A Gasbarrini, V Ojetti, F Franceschi, D Pitocco, E Sanz Torre, M Candelli, A=De Luca, R Nocente, G Ghirlanda and G Gasbarrini. Rome and Bologna, Italy Effect of H. pylori e r a d i c a t i o n o n t h e gross lesion a n d histology of v a r i o l i f o r m gastritis. (Abstract# G0814) KM Lee, DH Lee, KL Lee, MS Jang, HC Jung, IS Song and CY Kim. Seoul, Korea

Helicobacter pylori a n d c h r o n i c u r t i c a r i a : the role of e r a d i c a t i o n . (Abstract# G0343) P Carnevale, L Bierti, P Pigatto, P MaseUis and R de Franchis. Milan, Italy

Celiac disease i n t h e elderly: e x p e r i e n c e i n the U.S. (Abstract# G1705) SN Stavropoulos, PHR Green, SG Panagi and SL Goldstein. New York, NY S m a l l i n t e s t i n a l m a l i g n a n c y a n d celiac disease. (Abstract# G1706) SN Stavropoulos, PHR Green, SG Panagi, E Blanco, KA F0rde, SL Goldstein, H Ahsan and AI Neugut. New York, NY

Effect of e n t e r a l i n u l i n o n the p o u c h disease a c t i v i t y i n d e x a n d o n e p i t h e l i a l gene e x p r e s s i o n w i t h i n the i l e o a n a l pouch: a r a n d o m i z e d , placebo-controlled, crossover study. (Abstract# G1618) HP Meijer, CFM Welters, E Heineman, GS Salomons, HA Bfiller, J Dekker and AWC Einerhand. Amsterdam, Maastricht and Rotterdam, The Netherlands

April1998

PROGRAMOF TH]EANNUALMEETINGP69

A G A P O S T E R S E S S I O N m M O N D A Y , MAY 18, 1998 High p r e v a l e n c e of PCR p o s i v i t y for Tropheryma wbippelilin gastric j u i c e a n d d u o d e n a l mucosa of p a t i e n t s w i t h o u t Whipple's disease. (Abstract# G1489) HU Ehrbar, F Dutly, HR Koelz, M Fried, T Breitbach, M Spycher, M Altwegg and P Bauerfeind. Z~irich, Switzerland High p r e v a l e n c e of g a s t r o i n t e s t i n a l symptoms i n F a b r y ' s disease. (Abstract# G1506) L Fiedler, P Ashton-Prolla, C Eng and MW Babyatsky. New York, NY U p d a t e d r e s u l t s from a N o r t h A m e r i c a n c e n t e r o n n e o p l a s t i c d i s o r d e r s i n a d u l t celiac disease. (Abstract# G1507) HJ Freeman. Vancouver, Canada Beneficial effects of p e c t i n a n d r a w b a n a n a i n t h e d i e t a r y m a n a g e m e n t of p e r s i s t e n t d i a r r h e a i n children. (Abstract# G1660) GH Rabbani, GJ Fuchs, T Teka and B Zaman. Dhaka, Bangladesh Celiac disease, l y m p h o c y t i c gastritis a n d Helieobaeter pyloriinfection. A c o n t r o l l e d study. (Abstract# G1482) A Diamantti, C Maino, H Vazquez, S Pedreira, S Niveloni, E Smecuol, A Fiorini, A Cabanne, L Boerr, Z Kogan, E Maurin5 and JC Bai. Buenos Aires, Argentina D e t e c t i o n a n d s e q u e n c i n g of measles v i r u s i n p e r i p h e r a l blood m o n o n u c l e a r cells i n p a t i e n t s with i n f l a m m a t o r y bowel disease. (Abstract# G1570) H Kawashima, T Mori, Y Kashiwagi, K Takekuma, A Hoshika, S Schepelmann, RE Pounder, JA Walker-Smith and AJ Wakefield. Tokyo, Japan and London, United Kingdom Small bowel l y m p h o m a i n s i l e n t celiac disease: a cause for c o n c e r n ? (Abstract# G1562) SD Johnston and RGP Watson. Belfast, Northern Ireland C h a r a c t e r i z a t i o n of a c u t e colitis i n i m m u n o c o m p e t e n t adults: a p r o s p e c t i v e series of 93 cases. (Abstract# G1430) L Beaugerie, F Barbut, N Delas, S Fossati-Marchal, P Aygalenq, P Lahmek, G Bellaiche, K Vahedi, I Rosa, O Fourdan, M Levy, N Ganne-Carrie, M Gaudric, N Delphin and C Ciwyner. Paris, France Dynamic anorectal endoluminal ultrasonography detects enteroceles. (Abstract# G1566) M Karaus, P Neuhaus and B Wiedenmann. Berlin, Germany Suggestions t h a t g l u t e n s e n s i t i v i t y is n o t a c o m m o n f e a t u r e of u n c l a s s i f i e d n e u r o l o g i c a l disorders. (Abstract# G1484) P Doldo, R Marasco, A Aloi, U Aguglia, M Zappia, C Cosco, A Quattrone and F Pallone. Catanzaro, Italy

Celiac disease-like i n t e s t i n a l a n t i b o d y p a t t e r n i n p a t i e n t s with i r r i t a b l e bowel s y n d r o m e . (Abstract# G1753) U Wahnschaffe, JD Schulzke, EO Riecken and R Ullrich. Berlin, Germany Search for a cause i n c u l t u r e n e g a t i v e acute colitis i n J a p a n : r o t a v i r u s i n f e c t i o n i n adults. (Abstract# G1635) H Nakajima, K Muramoto, T Mikami, K Kawata and H Nara. Kuroishi City, Japan Assessment of i n t e s t i n a l p e r m e a b i l i t y with a t w o - h o u r u r i n e collection. (Abstract# G1416) S Akram, S Mourani, C-N Ou, C Rognerud, R Sadiq and R Goodgame. Houston, TX S c r e e n i n g of first degree r e l a t i v e s for celiac disease i n the U.S. (Abstract# G1493) S Eng, PHR Green, A Hammed, K Horvarth, SL Goldstein and A Fasano. New York, NY and Baltimore, MD Right colonic i n v o l v e m e n t a n d h e m o d i a l y s i s are associated with severe o u t c o m e i n p a t i e n t s with ischemic colitis. (Abstract# G1461) C Cellier, C Flobert, A Berger, A Ngo, E Cuillerier, B Landi, P Marteau, PH Cugnenc and JP Barbier. Paris, France Diagnositc yield of p u s h e n t e r o s c o p y i n p a t i e n t s w i t h m a l a b s o r p t i o n . (Abstract# G1459) C Cellier, E Cuillerier, N Patey, P Marteau, J Bri~re, N Brousse, J-P Barbier and B Landi. Paris, France

DDW Poster of Distinction: Refractory sprue: histological a n d p h e n o t y p i c a l features, a n d outcome. (Abstract# (]1460) C Cellier, C Helmer, N Patey, B Jabri, C Matuchansky, R Modigliani, E Lerebours, JF Colombel, JC Delchier, L Mauvieux, E Macintyre, N Cerf-Bensussan, N Brousse and JP Barbier. Paris and Cr~teil, France I d e n t i f i c a t i o n of food allergens i n g a s t r o i n t e s t i n a l allergy: a c c u r a c y of s e r u m PAST a n d endoscopicguided lavage. (Abstract# G1694) D Schwab, M Raithel, M Weidenhiller, S Winterkamp, J Hochberger and EG Hahn. ErlangenNuremberg, Germany I n h i b i t i o n of gastric s e c r e t i o n relieves p o s t p r a n d i a l urgency, d i a r r h e a a n d c r a m p s i n a v a r i e t y of GI disorders. (Abstract# G1676) W Rubin, C Maxson, R Koerner and D Bhavin. Philadelphia, PA; Palm Beach Gardens, FL and Dover, DE P e r m e a b i l i t y tests detect celiac disease i n first-degree relatives. P r e l i m i n a r y results. (Abstract# G1701) E Smecuol, S Pedreira, S Niveloni, H Vazquez, E Maurifio, JC Bai and J Meddings. Buenos Aires, Argentina and Calgary, Canada

R e f r a c t o r y celiac disease is d u e to celiac disease. (Abstract# G1653) JM Poneros, H Rotterdam and PHR Green. New York, NY

Celiac disease a n d epilepsy w i t h c e r e b r a l calcifications. (Abstract# G1577) P Kenny, R Benavente and J De Paula. Buenos Aires, Argentina

R e p o r t s of a b d o m i n a l c r a m p i n g p a i n a n d u r g e n c y are c o r r e l a t e d w i t h c h a n g e s i n stool viscosity. (Abstract# G1616) J McRorie, N Zorich and R Giannella. Cincinnati, OH

Bone m i n e r a l d e n s i t y i n p a t i e n t s w i t h celiac disease: a U.S. study. (Abstract# G1624) DF Meyer, B Diamond, E Blanco, E Shane and PHR Green. New York, NY

C a n c e r r i s k i n p a t i e n t s w i t h collagenous a n d l y m p h o c y t i c colitis. (Abstract# G1462) JL Chan, AC Tersmette, GJA Offerhaus, SB Gruber and FM GiardieUo. Baltimore, MD and Amsterdam, The Netherlands

Lack of association of sarcoidosis a n d i n t e s t i n a l l y m p h o m a w i t h T. wln'ppelii infection. (Abstract# G1413) MF Abdelmalek, GW Procop, PS Mitchell and DH Persing. Rochester, MN

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GASTROENTEROLOGY VoL 114~ No. 4

AGA POSTER SESSION - - MONDAY, MAY 18, 1998

DDW Poster of Distinction: I m p a i r e d Na÷-K+ p u m p a c t i v i t y i n the erythrocytes of c h i l d r e n w i t h t r e a t e d celiac disease. (Abstract# G1423) A Arat6, M Dobos, B V~s~rhelyi, H Bod~nszky and T Tulassay. Budapest, Hungary

DDW Poster of Distinction: L a t h o s t e r o l to cholesterol r a t i o s i n cystic fibrosis. (Abstract# G1480) JC Deutsch, M Cz0pek, J Bisping, D Rodman and JF Kolhouse. Denver, CO Low e x p r e s s i o n of i n t e s t i n a l trefoil factor i n celiac disease. (Abstract# G1469) C Ciacci, D Di Vizio, L Insabato, G Savino, G Mazzacca and DK Podolsky. Naples, Italy and Boston, MA Wheat s t a r c h c o n t a i n i n g gluten-free p r o d u c t s i n the t r e a t m e n t of g l u t e n i n t o l e r a n c e . (Abstract# G1569) K Kaukinen, P Collin, K Holm, I Rantala, N Vuolteenaho, T Reunala and M M~ki. Tampere, Finland P l a s m a c i t r u l l i n e : a b i o c h e m i c a l m a r k e r of e n t e r o c y t e mass i n villous atrophy. (Abstract# G1474) P Crenn, K Vahedi, C Coudray-Lucas, A Lavergne, L Cynober, C Matuchansky and B Messing. Paris, France

II

Tissue t r a n s g l u t a m i n a s e a u t o a n t i b o d y e n z y m e - l i n k e d i m m u n o s o r b e n t assay i n d e t e c t i n g celiac disease. (Abstract# G1715) S Sulkanen, T Halttunen, I Korponay-Szabo, K Laurila, P Collin and M M/iki. Tampere, Finland I N T E S T I N A L DISORDERS - - I N T E S T I N A L TRANSPORT I K-depletion regulates apical Na- a n d K - d e p e n d e n t H ÷e x t r u s i o n i n r a t distal colon. (Abstract# G1496) SI Escalera, AC Cimini, HJ Binder and SK Singh. New Haven, CT Ca 2÷- a n d cAMP-mediated CI" s e c r e t i o n i n r a t distal colon differ i n t h e i r o r i g i n as j u d g e d b y c o n d u c t a n c e s c a n n i n g . (Abstract# G1544) B Hoppe, I Grotjohann, AH Gitter, JD Schulzke and M Fromm. Berlin, Germany An u n u s u a l b a r r i e r to p e r m e a n t molecules is expressed i n c r y p t - n o t surface - epithelium. (Abstract# G1700) SK Singh and AC Cimini. New Haven, CT Effect of c h r o n i c i n f l a m m a t i o n o n ileal s h o r t c h a i n fatty a c i d : b i c a r b o n a t e exchange. (Abstract# G1610) T Manokas, JJ Fromkes and U Sundaram. Columbus, OH

Bile acid m a l a b s o r p t i o n as a cause of c h r o n i c d i a r r h e a : d i a g n o s t i c u s e f u l n e s s of 7c~-hydroxy-4-cholesten-3-one i n serum. (Abstract# G1689) G Sauter, C von Ritter and G Paumgartner. Munich, Germany

Electrophysiological c h a r a c t e r i z a t i o n of h u m a n sigmoid colon e p i t h e l i u m resected u s i n g a novel endoscopic technique. (Abstract# G1611) JA Marrero, DA Ostrovskiy, KA Matkowskyj, S Koutsouris, G Hecht and RV Benya. Chicago, IL

P l a t e l e t factor 4 a n d B-thromboglobulin i n p a t i e n t s w i t h i n f l a m m a t o r y bowel disease a n d i n p a t i e n t s w i t h g i a n t cell arteritis. (Abstract# G1752) AA Vrij, J Rijken, JWJ van Wersch and RW Stockbriigger. Maastricht and Heerlen, The Netherlands

Molecular c h a r a c t e r i z a t i o n a n d e x p r e s s i o n of the h u m a n Na+/H÷ e x c h a n g e r isoform NHE-2. (Abstract# G1609) J Malakooti, RY Dahdal, L Schmidt, TJ Layden, PK Dudeja and K Ramaswamy. Chicago, IL

S t u d y of orocecal t r a n s i t a n d i n t e s t i n a l a b s o r p t i o n of s t a r c h by Hz-CH4 b r e a t h test i n f u n c t i o n a l g a s t r o i n t e s t i n a l disorders. (Abstract# G1747) M Ventrucci, GM Ubalducci, A Cip011a, M Midd0nn0, MA Panella and E R0da. Bologna, Italy

S u b s t r a t e a n d i n h i b i t o r specificities of t h e SCFA'/HCO~" e x c h a n g e r i n apical m e m b r a n e vesicles of t h e r a t distal colon. (Abstract# G1646) J Opritz, O Schr6der, WF Caspary and J Stein. Frankfurt, Germany

The diagnostic v a l u e of a n t i - e n d o m y s i u m a n d a n t i g l i a d i n a n t i b o d i e s i n u n t r e a t e d celiacs: d i s a p p o i n t i n g i n clinical practice. (Abstract# G1674) K R0stami, J Kerckhaert, R Tiemessen, BME yon Blomberg, JWR Meijer and CJJ Mulder. Arnhem and Amsterdam, The Netherlands

The r o t a v i r a l e n t e r o t o x i n NSP4 elevates i n t e s t i n a l cell c a l c i u m a n d causes d i a r r h e a i n cystic fibrosis mice. (Abstract# G1633) AP Morris, JM Ball, CQ-Y Zeng, JK Scott, WK O'Neal and MK Estes. Houston, TX

S e n s i t i v i t y a n d specificity of tissue t r a n s g l u t a m i n a s e test, a n t i g l i a d i n a n d a n t i e n d o m y s i u m c o m p a r e d to the h i s t o p a t h o l o g i c a l f e a t u r e s of celiac disease. (Abstract# G1673) K Rostami, S Stapel, JWR Meijer and CJJ Mulder. Arnhem and Amsterdam, The Netherlands

DDW Poster of Distinction: Cellular SCFA c o n t e n t of colonic e p i t h e l i a l cells (HT29C1) is d e p e n d e n t on r e g u l a t i o n of i n t r a c e l l u l a r a n d e x t r a c e l l u l a r pH. (Abstract# G1468) S Chu, H Lee, U Pilatus and MH Montrose. Baltimore, MD

DDW Poster of Distinction:

H i n d gut c o n t r i b u t i o n to stool fat values i n p a n c r e a t i c exocrine i n s u f f i c i e n t m i n i p i g s ± e n z y m e s u p p l e m e n t a t i o n . (Abstract# G1720) R Tabeling, PC Gregory, J Meil and J Kamphues. Hanover, Germany

F u n c t i o n a l c h a r a c t e r i z a t i o n of apical a n d b a s o l a t e r a l anion transporters in rabbit proximal duodenum. (Abstract# G1555) P Jacob, G Lamprecht, H Rossmann, M Gregor and U Seidler. Tfibingen, Germany

R e p o r t s of d i a r r h e a : w h e n is stool w a t e r o u t p u t c l i n i c a l l y m e a n i n g f u l ? A r a n d o m i z e d , controlled t r i a l of olestra a n d sorbitol. (Abstract# G1520) R Giannella, N Zorich, K Riccardi, T Filloon and J McRorie. Cincinnati, OH

Tight j u n c t i o n s t r u c t u r e is i m p a i r e d i n u l c e r a t i v e colitis. (Abstract# G1692) JD Schulzke, CJ Bentzel, H Schmitz, C Barmeyer, M Fromm and EO Riecken. Berlin, Germany and Greenville, NC Active a m m o n i u m i o n secretion i n colon. (Abstract# G1541) K Holtug, E Skadhauge and G Laverty. Copenhagen and HeUerup, Denmark; Newark, DE

April 1998

II

PROGRAM OFTHEANNUALMEETINGP71

A G A P O S T E R S E S S I O N - - M O N D A Y , M A Y 18, 1998

CI-HCOs a n d CI-OH exchanges of b a s o l a t e r a l m e m b r a n e s r e g u l a t e i n t r a c e l l u l a r pH i n c r y p t cells of r a t d i s t a l colon. (Abstract# G1549) M Ikuma, J Geibel, HJ Binder and VM Rajendran. New Haven, CT

Role of e n t e r i c n e r v e s i n a d a p t a t i o n of the small i n t e s t i n e after i s c h e m i a - r e p e r f u s i o n i n j u r y i n t h e rat. (Abstract# G1470) WC Conner, CM Gallagher, H Tavaf-Motamen, T Miner and T Shea-Donohue. Washington, DC and Bethesda, MD

R i g h t c o n t a i n e r for Ussing-type m e a s u r e m e n t s o n small i n t e s t i n a l forceps b i o p s y specimens. (Abstract# G1709) M Stockmann, AH Gitter, JD Schulzke and M Fromm. Berlin, Germany

A c t i v a t i o n of t r a n s c r i p t i o n a l factor AP-1 a n d NF-~B occurs i n cells s u r v i v i n g i n t e s t i n a l ischemiar e p e r f u s i o n i n rats. (Abstract# G1771) KY Yeh, M Yeh, DN Granger and J Glass. Shreveport, LA

A n o v e l m u t a t i o n of the d o w n r e g u l a t e d i n a d e n o m a gene i n a J a p a n e s e case w i t h c o n g e n i t a l chloride d i a r r h e a . (Abstract# G1498) Y Etani, S Mushiake, H Tajiri, K Miki, K Kozaiwa, A Sawada, K Tada and K Ozono. Osaka, Japan

R e g u l a t i o n of t h e PepT1 p e p t i d e t r a n s p o r t e r i n the r a t small i n t e s t i n e i n r e s p o n s e to 5-fluorouracil-induced i n j u r y . (Abstract# G1723) H Tanaka, T Shiraga, K M0rita, K Miyamote, Y Taketani and E Takeda. T0kushima, Japan

A n i o n e x c h a n g e i n h u m a n d u o d e n a l enterocytes in vitro is i n s e n s i t i v e to s t i l b e n e derivatives. (Abstract# G1613) B M~rtensson, J Bernard, V Pratha, DL Hogan and JI Isenberg. San Diego, CA

D i f l u o r o m e t h y l o r n i t h i n e i n h i b i t s c r y p t fission. (Abstract# G1727) JS Thompson, SK Saxena and JG Sharp. Omaha, NE

Selective decreases i n levels of mRNA e n c o d i n g a w a t e r c h a n n e l (AQP3) i n ileal m u c o s a after ileostomy. (Abstract# S0201) J Purdy, RR Cima, MA Doble, MJ Zinner and DI Soybel. Boston, MA I N T E S T I N A L DISORDERS - - MUCOSAL REPAIR AND P R O T E C T I O N S e c r e t i o n of t h e i n t e s t i n a l trefoil factor from the i s o l a t e d v a s c u l a r l y p e r f u s e d r a t colon. (Abstract# G1632) F Moro, F Levenez, H Guignard, JA Chayvialle, AS Giraud and JC Cuber. Lyon and Jouy-en-Josas, France and Melbourne, Australia Glucocorticoid i n d u c t i o n of i n t e s t i n a l epithelial h e a t shock p r o t e i n 72 involves t r a n s c r i p t i o n a l gene a c t i v a t i o n . (Abstract# G1738) S Urayama, MW Musch, D Straus and EB Chang. Chicago, IL Loss of a n c h o r a g e leads to extensive apoptosis of h u m a n i n t e s t i n a l epithelial cells, i n d e p e n d e n t of t h e i r l o c a t i o n o n t h e crypt-villus axis or the mode of isolation. (Abstract# G1530) J Grossmann, G Latella, C Fiocchi and AD Levine. Cleveland, OH and L'Aquila, Italy

D D W Poster of Distinction: Heat shock p r o t e i n s p r o t e c t the b a r r i e r f u n c t i o n of e p i t h e l i a l cell lines. (Abstract# G1503) H Feldhaar, J Ries, WF Caspary and J Stein. Frankfurt, Germany A n o v e l m u c i n - l i k e goblet cell specific gene homologous to a h u m a n IgGFc b i n d i n g p r o t e i n gene is r e g u l a t e d d u r i n g i n t e s t i n a l a d a p t a t i o n . (Abstract# G1717) EA Swietlicki, AE Davis, DC Rubin and MS Levin. St Louis, MO Effects of m e t h o t r e x a t e o n the i n t e s t i n a l e p i t h e l i u m are i n f l u e n c e d b y e n v i r o n m e n t a l changes. (Abstract# G1748) M Verburg, IB Renes, JAJM Taminiau, HA Biiller, J Dekker and AWC Einerhand. Amsterdam and Rotterdam, The Netherlands

I n t e s t i n a l r e s e c t i o n i n c r e a s e s e n t e r o c y t e apoptosis. (Abstract# G1728) JS Thompson and B Barent. Omaha, NE PANCREATIC DISORDERS - - E X P E R I M E N T A L PANCREATITIS

D D W Poster of Distinction: Differential expression of m i t o c h o n d r i a l mRNA i n p a n c r e a s a n d c o n t r o l sites of EtOH-fed rats. (Abstract# G1951) HS Li, J Rao, BS Thompson, XY Deng, PG Wood, PK Eag0n and DC Whitcomb. Pittsburgh, PA

D D W Poster of Distinction: C C K i n c r e a s e s c h e m o k i n e gene e x p r e s s i o n a n d NF-KB a c t i v a t i o n i n r a t p a n c r e a t i c a c i n a r cells in vitro. (Abstract# G1899) B Han and CD Logsdon. Ann Arbor, MI

I n t r a p a n c r e a t i c e x p r e s s i o n of cytokines IL-6 a n d KC is i n c r e a s e d i n c e r u l e i n p a n c r e a t i t i s : r e g u l a t i o n b y NF-~B. (Abstract# G1803) TA Blinman, I Guk0vsky, A Guk0vskaya, V Zanin0vic, SJ Pandol and E Livingston. Los Angeles, CA The e x p r e s s i o n of cellular a d h e s i o n molecules is u p r e g u l a t e d a n d colocalized w i t h t h e oxidative stress i n t h e e a r l y course of e x p e r i m e n t a l a c u t e p a n c r e a t i t i s . (Abstract# G2053) G Telek, JY Sc0azec, J Chariot, G Feldmann and C Roz~. Paris, France E x p r e s s i o n of apoptosis-related genes d u r i n g a c u t e p a n c r e a t i t i s . (Abstract# G1883) G Gomez, E Englander, S Rajaraman, P Gomez, JC Thompson and GH Greeley, Jr. Galveston, TX Successful gene t r a n s f e r i n d u c e s local a n d systemic i n f l a m m a t i o n w o r s e n i n g p a n c r e a t i t i s severity. (Abstract# G1839) W Denham, D Denham, J Yang, S MacKay, LL Moldawer and J Norman. Tampa and Gainesville, FL I d e n t i f i c a t i o n , c u l t u r e a n d c h a r a c t e r i z a t i o n of fats t o r i n g stellate cells from mice, r a t s a n d h u m a n pancreas. (Abstract# G1788) MG Bachem, E Schneider, H Gross, H Weidenbach, A Menke, R Schmid, G Adler and A Grfinert. Ulm, Germany

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I n d u c t i o n of TFF-1 i n t h e p a n c r e a s o v e r - e x p r e s s i n g t r a n s f o r m i n g g r o w t h f a c t o r - a l p h a . (Abstract# G1852) M Ebert, J Hoffmann, C Hackel, K Rutkowski, RM Schmid, A Roessner, W Hoffmann, G Adler and P Malfertheiner. Magdeburg and Ulm, Germany

Myofibroblast proliferation, enhanced fibrogenesis and defective p a n c r e a t i c r e p a i r i n d u c e d b y c y c l o s p o r i n e . (Abstract# G2062) E Vaquero, X Molero, V Puig-Divi, X Tian, A Salas and JR Malagelada. Barcelona and Terrassa, Spain

D i f f e r e n t i a l r e g u l a t i o n of p a n c r e a t i c genes d u r i n g experimental pancreatitis, investigated by differential d i s p l a y a n a l y s i s . (Abstract# G2078) A Wilmen, M Strowski, T HSfken, P F~iller, H Printz, B GSke and ACC Wagner. Marburg, Germany

E x p r e s s i o n of c y t o k i n e mRNA i n a n e x p e r i m e n t a l m o d e l of c h r o n i c p a n c r e a t i t i s . (Abstract# G2039) G Sparmann, J Merkord, S Behrend, S Liebe and J Emmrich. Rostock, Germany

M o n o c l o n a l a n t i b o d i e s a g a i n s t ICAM-1 r e d u c e s e p t i c c o m p l i c a t i o n s i n a c u t e p a n c r e a t i t i s . (Abstract# G2074) J Werner, K Z'graggen, W Hartwig, E Schmidt, L Herzog, T KSppel, P Sinn, MM Gebhard, C Herfarth and E Klar. Heidelberg, Germany and Bern, Switzerland The p a t h o g e n e s i s of p a n c r e a t i c i n j u r y b y e t h a n o l a n d its n o n - o x i d a t i v e m e t a b o l i t e s . (Abstract# G2075) J Werner, K Z'graggen, C Fernandez del-Castfllo, K Lewandrowski, M Laposata, DW Rattner and AL Warshaw. Boston, MA P a n c r e a t i c a - s m o o t h m u s c l e a c t i n a n d collagen I e x p r e s s i o n i n a m u r i n e m o d e l of p r o g r e s s i v e p a n c r e a t i c fibrogenesis. (Abstract# G1979) BA Neuschwander-Tetri, LD Wells and JE P0ul0s. St Louis, MO P r e s e r v a t i o n of p h y s i o l o g i c p a r a m e t e r s d u r i n g experimental pancreatitis by macrophage pacification. (Abstract# G2080) J Yang, W Denham, KJ Tracey and J Norman. Tampa, FL P o l y u n s a t u r a t e d p h o s p h a t i d y l c h o l i n e effectively r e d u c e s c o l l a g e n d e p o s i t i o n in e x p e r i m e n t a l c h r o n i c p a n c r e a t i t i s . (Abstract# G2005) V Puig-Divf, X Molero, E Vaquero, A Salas, F Guarner, L Guarner and J-R Malagelada. Barcelona and Terrassa, Spain N u c l e a r factor-KB a c t i v a t i o n in c e r u l e i n p a n c r e a t i t i s . (Abstract# G2041) ALl Steinle, H Weidenbach, M Wagner, G Adler and RM Schmid. Ulm, Germany A l t e r a t i o n of m y o f i b r o b l a s t l o c a l i z a t i o n , b a s i c fibroblast growth factor and platelet-derived growth f a c t o r i m m u n o r e a c t i v i t y in o n s e t a n d r e s t o r a t i o n p r o c e s s of c a e r u l e i n - i n d u c e d a c u t e p a n c r e a t i t i s i n r a t . (Abstract# G1983) H Nishino, M Nakamura, H Tomita, A Niitu, M Kohno, H Ishii and N Tajima. Tokyo, Japan P a n c r e a t i c s t e l l a t e cells a r e a c t i v a t e d i n h u m a n a n d e x p e r i m e n t a l p a n c r e a t i c fibrosis. (Abstract# G1895) P Haber, G Keogh, M Apte, C Moran, R Pirola, G McCaughan, M Korsten and J Wilson. Sydney, Australia and New York, NY D i r e c t e v i d e n c e for p r e m a t u r e p r o t e a s e a c t i v a t i o n in l i v i n g p a n c r e a t i c a c i n a r cells. (Abstract# G1938) B Kriiger, W Tessenow and MM Lerch. Rostock and Muenster, Germany A c u t e p a n c r e a t i t i s a n d p a n c r e a t i c fibrosis i n r a t s a f t e r single t r e a t m e n t w i t h d i b u t y l t i n d i c h l o r i d e i n d e p e n d e n c e o n d o s e a n d time. (Abstract# G1966) J Merkord, H Weber, G Sparmann and G Henninghausen. Rostock, Germany Peroxynitrite-mediated tissue damage in necrohemorrhagie but not edematous pancreatitis. (Abstract# G2063) E Vaquero, X Molero, X Tian, A Salas, F Guarner and JR Malagelada. Barcelona and Terrassa, Spain

c-met p r o t o o n c o g e n e x p r e s s i o n a f t e r c e r u l e i n - i n d u c e d a c u t e p a n c r e a t i t i s a n d its r e g u l a t i o n b y c y t o k i n e s . (Abstract# G1992) JM Otte, K Kiehne, F Schmitz, UR F61sch and KH Herzig. Kiel, Germany E n d o t h e l i n r e c e p t o r b l o c k a d e in a c u t e p a n c r e a t i t i s f u r t h e r evidence for d e c r e a s e d c a p i l l a r y p e r m e a b i l i t y , a n d i m p r o v e d m i c r o c i r c u l a t i o n , a n d o r g a n function. (Abstract# G1864) T Foitzik, HG Hotz, B Hotz, G Eibl, J Faulhaber, M Kirchengast and HJ Buhr. Berlin and Ludwigshafen, Germany H e a t s h o c k p r o t e i n 70 e x p r e s s i o n r e d u c e s t h e s e v e r i t y of c a e r u l e i n - i n d u c e d a c u t e p a n c r e a t i t i s b y r e d u c i n g i n t r a p a n c r e a t i c a c t i v e t r y p s i n levels. (Abstract# G1869) JL Frossard, A Saluja, HS Lee, L Bhagat, M Bhatia and M Steer. Boston, MA

DDW Poster of Distinction: D e l e t i o n of ICAM-1 gene r e d u c e s t h e s e v e r i t y of caerulein-induced pancreatitis and lung injury by i n t e r f e r i n g w i t h n e u t r o p h i l s e q u e s t r a t i o n in t h e p a n c r e a s a n d lung. (Abstract# G1868) JL Frossard, A Saluja, B Hofbauer, HS Lee, M Bhatia, L Bhagat and ML Steer. Boston, MA Role of t i s s u e t r a n s f o r m i n g g r o w t h factor-~l i n p a n c r e a t i c fibrosis. (Abstract# G2030) M Shi0zaki, Y Takeda, H M0rikawa, Y Nakagawa and K Katsu. Takatsuki and Ky0t0, Japan Hydrogen clearance measurement of pancreatic blood flow i n r a t s : a m i n i m a l l y i n v a s i v e t e c h n i q u e . (Abstract# G1880) B Gloor, Y Lei, JO Hines and HA Reber. Los Angeles, CA H e p a t i c c o n t r i b u t i o n to c i r c u l a t i n g c y t o k i n e levels in s e v e r e a c u t e p a n c r e a t i t i s in r a t s . (Abstract# G1879) B Gloor, TA Blinman, DA Rigberg, KE Todd, JS Lane, JO Hines and HA Reber. Los Angeles, CA An a n i m a l m o d e l o f a u t o i m m u n e p a n c r e a t i t i s u s i n g n e o n a t a l t h y m e c t o m i z e d mice. (Abstract# G2057) K Uchida, K Okazaki and T Chiba. Kyoto, Japan T u m o r n e c r o s i s f a c t o r gene p o l y m o r p h i s m a n d d i s e a s e s e v e r i t y in a c u t e p a n c r e a t i t i s . (Abstract# G2004) JJ P0well, AK Siriwardena, KCH Fear0n and JA Ross. Edinburgh, Scotland I n t e r l e u k i n - 1 gene locus p o l y m o r p h i s m s a n d d i s e a s e s e v e r i t y in a c u t e p a n c r e a t i t i s . (Abstract# G2001) J J Powell, JA Ross, KCH Fearon and AK Siriwardena. Edinburgh, Scotland The r i s e in s e r u m p a n c r e a t i c e n z y m e s p r e c e d e s t h e onset of p a n c r e a t i t i s i n t h e s e c r e t a g o g u e - i n d u c e d m o d e l of p a n c r e a t i t i s . (Abstract# G1801) GT Blevins, Jr and SS McCullough. Little Rock, AR

kprl11998

PROGRAM OF THE ANNUAL MEETING P73

AGA

POSTER

SESSION

I n c r e a s e d e x p r e s s i o n of t r a n s f o r m i n g g r o w t h factor-~l and extracellular matrix in chronic pancreatitis in two e x p e r i m e n t a l r a t models. (Abstract# G2051) M Tashiro, Y Kihara, H Nakamura and M Otsuki. Kitakyushu, Japan G r o w t h f a c t o r s i n t h e r e g e n e r a t i o n of e x p e r i m e n t a l p a n c r e a t i t i s . (Abstract# G1965) A Menke, C Philippi, H Yamaguchi, H Wecklein and G Adler. Ulm, Germany Epidermal growth factor limits pancreatic damage and accelerates pancreatic recovery after cerulein-induced p a n c r e a t i t i s . (Abstract# G1836) A Dembifiski, Z Warzecha, PC Konturek, P Ceranowicz, J Stachura and SJ Konturek. Cracow, Poland and Erlangen, Germany I n c r e a s e d e x p r e s s i o n of s m o o t h m u s c l e a - a c t i n localizes to a r e a s o f p a n c r e a t i c f i b r o s i s i n a novel m o d e l of severe hyperstimulation/obstruction pancreatitis. (Abstract# G1976) KM Murayama, B Barent, A Brooks, SC Eliason, EM Brunt, GA Smith, FR Burton, RS Britton and BA NeuschwanderTetri. St Louis, MO and Omaha, NE P a n c r e a t i c p r o t e a s e s i n l y m p h a n d b l o o d of r a t s w i t h c e r u l e i n p a n c r e a t i t i s . (Abstract# G1904) W Hartwig, J Werner, EA Carter, RE Jimenez, S Kupa, AL Warshaw and C Fernandez-del Castillo. Boston, MA F a s a n d F a s l i g a n d s y s t e m as a m e d i a t o r of p a n c r e a t i c a c i n a r cell a p o p t o s i s a f t e r p a n c r e a t i c d u c t ligation. (Abstract# G2081) H Yasuda, K Kataoka, M Moriguchi, K Kashima, H Ichimura, T Iida and J Imanishi. Kyoto, Japan

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MOI~DAY~

MAY

18~ 1998

Hyperthermia-mediated protection against acute p a n c r e a t i t i s is a s s o c i a t e d w i t h a n a c t i v a t i o n of t h e p a n c r e a t i c a n t i o x i d a t i v e d e f e n s e system. (Abstract# G2072) H Weber, ACC Wagner, J Jonas and J Merkord. Rostock and Marburg, Germany The t o t a l a n t i o x i d a n t s t a t u s i n e d e m a t o u s a n d n e c r o t i z i n g p a n c r e a t i t i s . ( A b s t r a c t # G1929) CD Kim, KH Kim, HS Lee, SJ Lee, HJ Park, YT Jeen, HJ Chun, CW Song, SW Lee, SH Urn, JH Choi, HS Ryu and JH Hyun. Seoul, Korea T r y p s i n o g e n a c t i v a t i o n p e p t i d e a n d c a t h e p s i n B a r e colocalized within cytoplasmic vacuoles during the early stages o f c a e r u l e i n - i n d u c e d p a n c r e a t i t i s . (Abstract# G1793) L Bhagat, A Saluja, HS Lee, JL Fr0ssard, M Bhatia and ML Steer. Boston, MA A c i n a r cell c y t o p l a s m i c v a c u o l e g e n e r a t i o n i n v/vo a n d i n v/tro u n d e r s e c r e t a g o g u e h y p e r s t i m u l a t i o n (Abstract# G1991). T Otani, MM Lerch and FS Gorelick. West Haven, CT and M~nster, Germany. P r o t e c t i o n of t h e a c i n a r cells b y l i p o p o l y s a c c h a r i d e i n a c u t e c e r u l e i n - i n d u c e d p a n c r e a t i t i s . Role of e n d o g e n o u s n i t r i c o x i d e a n d p r o s t a g l a n d i n . (Abstract# G1918) J Jaw0rek, B Jachimczak, R Tomaszewska, J Stachura, R Sendur, WW Pawlik, A Dembiflski, Z Warzecha and SJ Konturek. Cracow, Poland BILIARY D I S O R D E R S - - D I A G N O S I S

DDW Poster of Distinction:

C a d h e r i n / c a t e n i n c o m p l e x e s do n o t m e d i a t e t h e CCKinduced actin filament breakdown in rat pancreatic acini. (Abstract# G1945) J Leser, OA Musa, G Adler and MP Lutz. Ulm, Germany

B i l a t e r a l m e t a l s t e n t s for h i l a r s t e n o s e s - o p t i m a l t e c h n i q u e identified. (Abstract# G2120) R Dumas, N Demuth, MJM Buckley, JF Demarquay and JP Delmont. Nice, France

Role of e n d o t h e l i a l a c t i v a t i o n i n a c u t e p a n c r e a t i t i s . (Abstract# G1964) A Masamune, T Shimosegawa, M Fujita, M K0izumi and T Toyota. Sendal, Japan

DDW Poster of Distinction:

I n f l u e n c e of g l u t a t h i o n e s y n t h e s i s on t h e c o u r s e of a c u t e e x p e r i m e n t a l p a n c r e a t i t i s i n t h e r a t . (Abstract# G1781) G Alsfasser, L Herzog, M Gock, J Weruer, E Ryschich, J Schmidt, MM Gebhard, C Herfarth and E Klar. Heidelberg, Germany W a t e r i m m e r s i o n s t r e s s a n d HSP60 e x p r e s s i o n p r o t e c t against caerulein-induced pancreatitis by preventing i n t r a - a c i n a r cell a c t i v a t i o n of t r y p s i n o g e n . (Abstract# G1943) HS Lee, A Saluja, JL Frossard, L Bhagat, M Bhatia and ML Steer. Boston, MA H y p e r t h e r m i a - i n d u c e d e x p r e s s i o n of h e a t s h o c k protein prevents death in necrotizing pancreatitis. (Abstract# G1888) K Grise, F Kim and D McFadden. Los Angeles and North Hills, CA Role of t h e k i n i n - m e d i a t e d e d e m a for t h e a c c u m u l a t i o n of k i n i n s i n t h e p a n c r e a s i n e x p e r i m e n t a l p a n c r e a t i t i s . (Abstract# G1887) T Griesbacher, F Lembeck, M Burchert and Ba Peskar. Graz, Austria and B0chum, Germany

M a l i g n a n t d i s t a l bile d u c t o b s t r u c t i o n - a p r o s p e c t i v e r a n d o m i z e d t r i a l w i t h t h r e e t y p e s of e n d o p r o s t h e s e s . (Abstract# G2100) C Benz, WR Martin, JC Arnold, D Schilling and JF Riemann. Ludwigshafen, Germany

DDW Poster of Distinction: M a n a g e m e n t of b i l i a r y a s c a r i a s i s b y e n d o s c o p i c r e t r o g r a d e c h o l a n g i o p a n c r e a t o g r a p h y . (Abstract# G2154) J Landaeta, PA Rivas-Vetencourt, M Rodriguez, G Veitia, I Hern~ndez, C Urdaneta, M Khassale, A Silva, P Valenzuela, MJ Zerpa and R Pifiero. Caracas, Venezuela

DDW Poster of Distinction: Effect of m a g n e t i c r e s o n a n c e c h o l a n g i o g r a p h y on p a t t e r n s of ERCP u s e i n p a t i e n t s u n d e r g o i n g cholecystectomy. (Abstract# G2260) Z Younes, F Regan, R Safdar, B Lacy and T Magnuson. Baltimore, MD

DDW Poster of Distinction: E x t r a h e p a t i c cholestasis: p r o s p e c t i v e c o m p a r i s o n of magnetic resonance cholangiography and endoscopic u l t r a s o n o g r a p h y . (Abstract# G2U6) PH Deprez, R Materne, J F Gig0t, A Geubel, J Pringot and BE Van Beers. Brussels, Belgium P r o s p e c t i v e t r i a l of c o m b i n e d e n d o s c o p i c u l t r a s o u n d a n d s t i m u l a t e d b i l i a r y d r a i n a g e for s u b t l e g a l l b l a d d e r d i s e a s e - p r e l i m i n a r y r e s u l t s . (Abstract# G2117) JE Dill. Roanoke, VA

II

P74 PROGRAMOFTHEANNUALMEETING

GASTROENTEROLOGYVol.114,No. 4

A G A P O S T E R S E S S I O N m MONDAY, MAY 18, 1998 L i n e a r e c h o e n d o s c o p y to e v a l u a t e for CBD stones; l e a r n i n g from a s u m m a r y of t h e first fifty cases. (Abstract# G2150) J Lachter, R Reshef, M ShiUer, A Lavy, A Suissa and K Yassin. Nahariya and Haifa, Israel T r a n s p a p i l l a r y b i o p s y of the g a l l b l a d d e r disease. (Abstract# G2246) Y Watanabe, H Goto, Y Hirooka, A Itoh, S Hayakawa, Y Ishiguro, S Kojima, S Hashimoto, T Hayakawa and Y Naitoh. Nagoya, Japan Magnetic r e s o n a n c e c h o l a n g i o g r a p h y versus endoscopic r e t r o g r a d e c h o l a n g i o p a n c r e a t i c o g r a p h y i n the diagnosis of bile d u c t o b s t r u c t i o n . (Abstract# G2134) G Hochwarter, K Rennet, C Sebesta, M Urban, N HSlbling, W Feil, S Stelzig and R Schiessel. Vienna, Austria

Is Alagille's a b e n i g n s y n d r o m e ? (Abstract# G2195) RE Quiros, ME Ament, MB Heyman, TR Hall, SV McDiarmid and JH Vargas. Los Angeles and San Francisco, CA Expression of v a s c u l a r e n d o t h e l i a l g r o w t h factor i n h u m a n g a l l b l a d d e r carcinomas. (Abstract# G2251) S Yamamoto, K Fujii, Y Kitadai, A Tsuchida, M Hirata, T Iwao, N Eguchi, T Sasaki, Y Kawasaki, K Morinaka and G Kajiyama. Hiroshima, Japan Bile infection precedes, n o t follows, the f o r m a t i o n of clogs o b s t r u c t i n g b i l i a r y e n d o p r o s t h e s e s a n d plays a basic role i n t h e clogging process. (Abstract# G2107) F Cetta, A Cariati, D Cetta, M Zuckermann, P Piro, C Baldi, M Gori and G Montalto. Siena and Genoa, Italy

Is aerobilia a d i a g n o s t i c sign for h e p a t o b i l i a r y s t e n t p a t e n c y ? (Abstract# G2142) G Jechart, J Barnett, T Rausch and M Wienbeck. Augsburg, Germany

The usefulness of m a g n e t i c r e s o n a n c e c h o l a n g i o p a n c r e a t o g r a p h y for the diagnosis of b i l i o p a n c r e a t i c disease. (Abstract# G2140) M Izumi, S Ohwada, I Takeyoshi, T Inoue, I Kurosawa, Y Kawashima, T Ogawa, T Ohya and Y Morishita. Takasaki and Maebashi, Japan

E v a l u a t i o n of t h e d e p t h of i n v a s i o n of bile duct c a n c e r b y i n t r a d u c t a l u l t r a s o n o g r a p h y . (Abstract# G2183) Y Noda, N Fujita, G Kobayashi, K Kimura, A Yago, A Matsunaga, T Yuki, M Nomura, T Sato and K Ishida. Sendal, Japan

Biliary f i b r o n e c t i n : s i g n i f i c a n t l i m i t a t i o n as a diagnostic tool i n m a l i g n a n t b i l i a r y o b s t r u c t i o n . (Abstract# G2111) MA Chowdhury, MJ Bourke, SJ Williams, D Abi-Hanna and EJ Favaloro. Westmead, Australia

The value of p e r o r a l cholangioscopy. (Abstract# G2188) M Ortner, D Graebe, J Weber, J Wirth and H Lochs. Berlin, Germany

Diagnosis of b i l i a r y c a n c e r i n n o n - i c t e r i c stage w i t h c h o l a n g i o p a n c r e a t o g r a p h y . (Abstract# G2200) J Sai, J Ariyama, M Suyama and Y Kub0kawa. Tokyo, Japan

Magnetic r e s o n a n c e c h o l a n g i o p a n c r e a t o g r a p h y for diagnosing anomalous pancreaticobiliaryjunction. (Abstract# G2222) M Sugiyama, Y Izumisato, M Tokuhara, M Nakashima, T Mori, Y Atomi and J Hachiya. Tokyo, Japan O p t i m i z i n g MR c h o l a n g i o p a n c r e a t o g r a p h y with singleshot fast spin-echo a n d r e s p i r a t o r y - t r i g g e r e d fast spinecho sequences. (Abstract# G2216) Y Shiratori, T Naiki, M Nagaki, N Murakami, T Kato, M Kanematsu, H Hoshi and H Moriwaki. Gifu, Japan Endoscopic r e s e c t i o n of e a r l y c a n c e r a n d a d e n o m a of the p a p i l l a of Vater. (Abstract# G2136) A Itoh, H Goto, Y Naitoh, Y Hirooka, S Hayakawa, Y Watanabe, S Kojima, S Hashimoto and T Hayakawa. Nagoya, Japan Images of b i l i a r y t r a c t m a l i g n a n c y b y autofluorescence endoscopic i m a g i n g system: a pilot study. (Abstract# G2139) K Izuishi, H Tajiri, J Furuse, M Ryu, Y Maru, S Abe, T Kinoshita, M Konishi, H Inoue and S Yoshida. Chiba, Japan Endoscopic m a n a g e m e n t of b i l i a r y complications after orthotopic liver t r a n s p l a n t a t i o n . (Abstract# G2198) AF Rossi, C Grosso, G Zanasi, P Gambitta, M Bini, Z Pirone and R Arcidiacono. Milan, Italy C o m p a r i s o n of ERCP a n d m a g n e t i c r e s o n a n c e c h o l a n g i o g r a p h y i n p r i m a r y sclerosing cholangitis. (Abstract# G2206) M Scheurlen, H MSrki S Prier, C-P Klein, D Hahn and A Trusen. W~irzburg and Bad Kissingen, Germany C o n t r a s t - e n h a n c e d endoscopic u l t r a s o n o g r a p h y i n g a l l b l a d d e r diseases. (Abstract# G2133) Y Hirooka, H Goto, A Itoh, S Hayakawa, Y Watanabe, Y Ishiguro, S Kojima, S Hashimoto, T Hayakawa and Y Naitoh. Nagoya, Japan

MR

Respective v a l u e of a l k a l i n e p h o s p h a t a s e , GGT a n d 5' n u c l e o t i d a s e s e r u m activity i n t h e diagnosis of cholestasis. A prospective s t u d y of 65 p a t i e n t s . (Abstract# G2203) T Sapey, MH Mendler, D Guyader, O Morio, S Corbinais, Y Deugnier and P Brissot. Rennes, France How should u n e x p l a i n e d c h r o n i c a n i c t e r i c cholestasis be investigated? (Abstract# G2202) T Sapey, MH Mendler, D Guyader, B Turlin, V CanvaDelcambre, O Mori0, Y Deugnier and P Briss0t. Rennes, France J u x t a p a p i l l a r y d u o d e n a l d i v e r t i c u l a are s t r o n g l y associated w i t h c o m m o n bile d u c t stones a n d show less m a l i g n a n c i e s i n the b i l i o p a n c r e a t i c system. (Abstract# G2264) T Zoepf, DS Zoepf and JF Riemann. Ludwigshafen, Germany Chronic acalculous cholecystitis: c o r r e l a t i o n of h e p a t o b i l i a r y scan, clinical assessment, l a b o r a t o r y d a t a a n d final histopathology. (Abstract# G2105) MF Catalano, P Pruessing, DJ Geenen, MJ Schmalz, JB Nelson, GK Johnson, E Alcocer, WJ Hogan and JE Geenen. Milwaukee, WI GASTROINTESTINAL ONCOLOGY - - EICOSINOIDS, CYCLOOXYGENASES AND NSAIDS Effect of olive oil u p o n colon c a r c i n o g e n e s i s i n rats: m o d u l a t i o n of the local s y n t h e s i s of eicosanoids. (Abstract# G2304) R Bartoll, F Fern~ndez:Bafiares, E Castell~, E Navarro, J Mafi~, M Alvarez, E Cabr~, C Pastor and MA GassuU. Badalona, Spain P r o s t a n o i d receptors on h u m a n gastric mucosa: localization a n d type. (Abstract# G2835) V Takafuji, D Lublin, K Lynch and JK Roche. Charlottesville, VA

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PROGRAM O F T H E ANNUAL MEETING P75

A G A P O S T E R S E S S I O N - - M O N D A Y , MAY 18, 1998

DDW Poster of Distinction: Transforming growth factor-~l induces cyclooxygenase-2 a n d p r o s t a g l a n d i n E2 s y n t h e s i s i n h u m a n colon a d e n o m a cells. (Abstract# G2765) D Saha, R Chinery, DM Rose, JD Morrow, RJ Coffey and RD Beauchamp. Nashville, TN A c t i v a t i o n of HER2 p a t h w a y i n d u c e s e x p r e s s i o n of cyclooxygenase-2, r e l e a s e of p r o s t a g l a n d i n E2 a n d m i t o g e n e s i s i n h u m a n c o l o r e c t a l c a n c e r cells. (Abstract# G2597) R Kumar, M Mandal, L Adam, D Bandyopadhyay, G Steinbach, J Mendelsohn and R Vadlamudi. Houston, TX Cyclooxygenase-2 is l o c a l i z e d to l a m i n a p r o p r i a cells i n M i n m o u s e i n t e s t i n e . (Abstract# G2523) MA Hull, JK Booth, N Scott, AF Markham and PL Coletta. Leeds, United Kingdom E x p r e s s i o n of cyclooxygenase-2 i n i n t e r s t i t i a l cells, b u t n o t i n t u m o r cells, of t h e h u m a n colonic a d e n o m a s . (Abstract# G2300) H Bamba, S Ota, A Kato, A Adachi, S Itoyama and F Matsuzaki. Saitama, Japan E x p r e s s i o n of c y c l o o x y g e n a s e 2 i n c o l o r e c t a l c a n c e r a n d i t s r e l a t i o n s h i p to survival. (Abstract# G2800) KM Sheehan, K Sheahan, DP O'Donoghue, D Fitzgerald and FE Murray. Dublin, Ireland N o n s t e r o i d a l d r u g - i n d u c e d fall i n HT-29 cell v i a b i l i t y c o r r e l a t e s w i t h p o t e n c y to i n h i b i t c y c l o o x y g e n a s e (COX) 1: u s e of COX-2 selective i n h i b i t o r s . (Abstract# G2642) SA McCartney, I Vojnovic, MJG Farthing and TD Warner. London, United Kingdom C e l l u l a r a n d m o l e c u l a r effects of a cyclooxygenase-2selective n o n s t e r o i d a l a n t i i n f l a m m a t o r y d r u g on c o l o r e c t a l a d e n o m a a n d c a r c i n o m a cell lines. (Abstract# G2416) DJE Elder, DE Halt0n and C Paraskeva. Bristol, United Kingdom

DDW Poster of Distinction: W i l d - t y p e p 5 3 - d e p e n d e n t u p r e g u l a t i o n of c-myc is associated with differential apoptotic response in i n d o m e t h a c i n - t r e a t e d h u m a n g a s t r i c c a n c e r cells. (Abstract# G1412) GH Zhu, BCY Wong, CK Ching, ST Yuen, EYT Chan, KC Lai and SK Lam. Hong Kong, China Downregulation of protein kinase C inhibits indomethacin-induced apoptosis in gastric epithelial cells b y d i f f e r e n t i a l r e g u l a t i o n of a p o p t o s i s - r e l a t e d genes. (Abstract# G2935) GH Zhu, BCY W0ng, CK Ching, KC Lai and SK Lain. H0ng Kong, China Effect of s u l i n d a c sulfone on p r o l i f e r a t i o n , apoptosis, and polyps in a clinical trial in familial adenomatous p o l y p o s i s w i t h r e c t a l polyps. (Abstract# G2881) R van Stalk, GT Budd, R Kresty, R Ganapathi, P Elson, J Church, G Piazza, B Fryer, K Pr0vencher, R Pamukcu, E Hawk, G KeUoff and G Stoner. Cleveland and Columbus, OH; Horsham, PA and Bethesda, MD C h a n g e i n a p o p t o s i s i n p a t i e n t s t r e a t e d w i t h sulindac. (Abstract# G2550) J J Keller, GJA Offerhaus, SN Goodman, M Zahurak, LM Hylind, SR Hamilton and FM Giardiello. Baltimore, MD and Amsterdam, The Netherlands

GASTROINTESTINAL ONCOLOGYP R O L I F E R A T I O N AND A P O P T O S I S C o r r e l a t i o n b e t w e e n i o d o d e o x y u r i d i n e a n d MIB-1 l a b e l l i n g i n d e x in g a s t r i c c a r c i n o m a s a n d a d j a c e n t n o r m a l g a s t r i c tissue. (Abstract# G2779) DL Schipper, MJM Wagenmans, WHM Peters, T Wobbes and DJT Wagener. Nijmegen, The Netherlands E a r l y , diffuse c a r c i n o m a s of t h e s t o m a c h e x h i b i t t h e differentiation sequence and proliferative architecture of g a s t r i c a n t r a l glands. (Abstract# G2701) M Noda M, R Poulsom, AM Hanby, T Hattori T and NA Wright. Ohtsu, Japan and London, United Kingdom The s t u d y of g a s t r i c e p i t h e l i a l cell p r o l i f e r a t i o n a n d a p o p t o s i s on mice model. (Abstract# G2921) T Yamaguchi, N Nakajima, H Kuwayama, Y Ito, A Iwasaki and Y Arakawa. Tokyo, Japan T h e r e l a t i o n s h i p of p r o l i f e r a t i o n a n d a p o p t o s i s in a t r o p h i c g a s t r i t i s i n f e c t e d w i t h Helicobactcrpylori. (Abstract# G2526) T Imai, N Nakajima, Y Ito, T Yamaguchi and Y Arakawa. Tokyo, Japan I n c r e a s e d e x p r e s s i o n of F a s in g a s t r i c e p i t h e l i a l cells i n f e c t e d b y Helicobactcrpylori. (Abstract# G2771) A Samanta, C Chang, T Chen, L Marquise and SM Smith. Newark, NJ G a s t r i c c e l l u l a r t u r n o v e r a n d t h e d e v e l o p m e n t of a t r o p h y a f t e r 31 y e a r s o f follow-up: a c a s e - c o n t r o l s t u d y . (Abstract# G2670) SF Moss, J Valle, AM Abdalla, M Siurala and P Sipponen. New York, N-Y;Madrid, Spain and Espoo, Finland G a s t r i c e n t e r o c h r o m a f f i n - l i k e t r a n s f o r m a t i o n is a s s o c i a t e d w i t h i n c r e a s e d e x p r e s s i o n of t h e G1 cell cycle r e g u l a t o r s c y c l i n D1 a n d CDK4. (Abstract# G2932) T Zhang, LH Tang, M Kidd, J L~uffer and IM Modlin. New Haven, CT Cell cycle a b n o r m a l i t i e s in s m a l l b o w e l t u m o r s . (Abstract# G2284) N Arber, H Hibshoosh, W Yasui, AI Neugut, A Hibshoosh, E Liberman, A Sgambato, IB Weinstein, E Tahara and PR Holt. Tel Aviv, Israel; New York, NY; San Jose, CA; Hiroshima, Japan and Rome, Italy Apoptosis and cytoproliferation in HCV-related liver d a m a g e . (Abstract# G2439) F Farinati, R Cardin, A D'Erric0, W Grigi0ni, M Fi0rentino and R Naccarato. Padua and Bologna, Italy M o r p h o l o g i c a l a n a l y s i s of t h e f a t e of e p i t h e l i a l cells i n h u m a n l a r g e i n t e s t i n e . (Abstract# G2302) DH Barlda and PR Gibson. Melbourne, Australia Cell p r o l i f e r a t i o n a n a l y s i s of fiat a n d p o l y p o i d a d e n o m a s of c o l o r e c t u m . (Abstract# G2715) S Orii, N Murata, S Nakamura, M Sugawara, H Takahasi, Y Fujino, C Aman0, M End0, S Suzuki, Y Takano and S Sato. Mori0ka, Japan S t u d y of t h e p a t h w a y of c o l o r e c t a l c a n c e r s development in serrated adenoma and adenocarcinoma d e r i v e d f r o m s e r r a t e d a d e n o m a . (Abstract# G2766) S Saito, M Ikegami, H Ikenebe, H Ichikawa and T Kodama. Tokyo and Kyoto, Japan A p o p t o s i s a n d cell p r o l i f e r a t i o n i n v a r i o u s m a c r o s c o p i c t y p e s of i n t r a m u c o s a l c o l o r e c t a l c a r c i n o m a . (Abstract# G2840) T Tanimoto, S Tanaka, K Haruma, Y Kitadai, M Yoshihara, K Sumii, G Kajiyama and F Shimamoto. Hiroshima, Japan

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D e v e l o p m e n t a n d p r o g r e s s i o n i n colorectal t u m o r . (Abstract# G2529) T Iwase, H Konishi, T Kodama, K Kashima and T Hattori. Kyoto and Shiga, Japan Red m e a t a n d colon cancer: t h e role of heine. (Abstract# G2795) A Sesink, D Termont, J Kleibeuker and R Van der Meer. Ede and Groningen, The Netherlands PKC isoforms i n i n t e s t i n a l m u c o s a a n d a d e n o m a s of APC MIN mice. (Abstract# G2576) IK Klein, SR Ritland, SC Ziesmer, LJ Burgart, PC Roche, SJ Gendler and WE Karnes, Jr. Rochester, MN; Scottsdale, AZ and Providence, RI

E x p r e s s i o n of Fas l i g a n d a n d p r o g r e s s i o n of the h u m a n esophageal s q u a m o u s cell carcinomas. (Abstract# G2574) Y Kitagawa, M Ueda, N Ando, S Ozawa and M Kitajima. Tokyo, Japan Fas a n d Fas l i g a n d e x p r e s s i o n i n esophageal s q u a m o u s cell c a r c i n o m a . (Abstract# G2754) DA Rigberg, J Centeno, FS Kim, MA C01e, K Swenson, M Maggard and DW McFadden. Los Angeles, CA E v i d e n c e for i m m u n e e v a s i o n by the "Fas c o u n t e r a t t a c k " in vlvo i n esophageal cancer. (Abstract# G2311) MW Bennett, J O'Connell, GC O'Sullivan, JK Collins and F Shanahan. Cork, Ireland C o r r e l a t i o n b e t w e e n t h e bcl-2, p53 a n d MDM2 p r o t e i n e x p r e s s i o n i n colorectal a d e n o c a r c i n o m a s . (Abstract# G2869) M Tzouvala, K Triantafyllou, N Kapranos, GV Papatheodoridis, A Zizi-Serbetzogl0u, I Elemenoglou, DG Karamanolis and SJ Hadziyannis. Athens, Greece GASTROINTESTINAL O N C O L O G Y G A S T R O I N T E S T I N A L CANCER SUSCEPTIBILITY: CLINICAL S T U D I E S

D D W Poster of Distinction: Genetic p o l y m o r p h i s m s of alcohol metabolic enzymes for liver cirrhosis a n d h e p a t o c e l l u l a r cancer. (Abstract# G2545) S Kato, M Onda, N Matsuda, H Yoshida, M Umehara, N Matsukura, A Tokunaga, T Tajiri and Z Naito. Tokyo, Japan

GASTROENTEROLOGYVol.114~No. 4

The i n c i d e n c e of i n v a s i v e colorectal c a n c e r s accompanied with adenomas in familial adenomatous polyposis. (Abstract# G2834) A Takada, T Akasu, Y Nakanishi, T Shimoda, S Fujita a n d Y Moriya. Tokyo, Japan F u n c t i o n a l outcome after colectomy a n d ileorectal a n a s t o m o s i s c o m p a r e d to proctocolectomy a n d ileop o u c h - a n a l a n a s t o m o s i s i n familial a d e n o m a t o u s polyposis. (Abstract# G2876) P van Duijvendijk, JFM Slors, CW Taat, P Oosterveld and HFA Vasen. Amsterdam, The Netherlands The significance of d u o d e n a l polyps - a five y e a r r e v i e w of histological f e a t u r e s a n d n a t u r a l history. (Abstract# G2490) RJH Hammett, TR Heap and R Eckstein. Sydney, Australia Size-dependent i n c r e a s e i n the levels of p r o t a g l a n d i n metabolites i n a d e n o m a s of p a t i e n t s w i t h familial a d e n o m a t o u s polyposis. (Abstract# (]2926) VW Yang, JM Shields, SR Hamilton, EW Spannhake, WC Hubbard, LM Hylind, CR Robinson and FM GiardieUo. Baltimore, MD E l e v a t i o n of i n t e s t i n a l p o l y a m i n e c o n t e n t precedes t u m o r d e v e l o p m e n t i n the rain mouse. (Abstract# G2424) SH Erdman, MB Powell, K Bohm, NA Ignatenko, S Willer, J Einspahr, CM Payne and EW Gerner. Tucson, AZ I n c r e a s e d e x p r e s s i o n of salivary g l a n d EGF i n the Min/+ mouse is r e v e r s e d b y / h f l u r b i p r o f e n . (Abstract# G2643) JD McCracken, Y Minyama, ED Murray, Jr, D Kant0ci, DD Quiggle, DD Leipold and WJ Wechter. L0ma Linda, CA Bile acid c o m p o s i t i o n i n bile from APC m u t a n t mice. (Abstract# G2843) S Tejpar, G De Pauw, D Claus, Y Ghoos and JJ Cassiman. Leuven, Belgium The f r e q u e n c y of high-risk familial colorectal cancer. (Abstract# G2553) S Khandekar, SK Kuwada, S Khullar, G Mineau, R Kerber and RW Butt. Salt Lake City, UT Does the r i s k of colorectal n e o p l a s i a i n c r e a s e i n p r o b a n d s w h e n a second p a r e n t is affected w i t h colorectal cancer? (Abstract# G2633) AJ Markowitz, TM Kuhn, A Hewlett, H Gerdes, AG Zauber and SJ Winawer. New York, NY

Variable p h e n o t y p e of familial a d e n o m a t o u s polyposis i n pedigrees w i t h 3' m u t a t i o n i n the APC gene. (Abstract# G2330) JD Brensinger, SJ Laken, MC Luce, SM P0well, GH Vance, DJ Ahnen, GM Petersen, SR Hamilton and FM GiardieU0. Baltimore, MD; Indianapolis, IN and Charlottesville, VA

Altered MLH1 a n d MSH2 e x p r e s s i o n i n colorectal c a n c e r is associated w i t h p r o x i m a l site b u t n o t r i s k of m e t a c h r o n i c i t y : r e s u l t s of a case-control study. (Abstract# G2289) HR Aslanian, D Ahlquist, L Burgart, P Roche, J Harrington, D Mahoney, A Zinsmeister and S Thibodeau. Rochester, MN

S c r e e n i n g for m u t a t i o n s of the a d e n o m a t o u s polyposis coli gene i n 67 I t a l i a n familial a d e n o m a t o u s polyposis: f u r t h e r evidence of complex g e n o t y p e - p h e n o t y p e correlations. (Abstract# G2315) L Bertario, M Giarola, L Stagi, S Presciuttini, P M0ndini, P Sala, M Eboli, MA Pierotti and P Radice. Milan and Pisa, Italy

I m m u n o h i s t o c h e m i c a l d e t e c t i o n of hMSH2 a n d hMLH1 as a s c r e e n i n g test i n the t u m o r cells of colon c a n c e r family syndromes. (Abstract# G2395) B Dieumegard, S Grandjouan, JC Sabourin, MC Le Bihan, P Lasser, P Duvillard, D Couturier and B Bressacde Paillerets. Paris and Villejuif, France

Genotype-phenotype correlations in patients with a t t e n u a t e d a d e n o m a t o u s polyposis c o i l (Abstract# G2819) C S0ravia, T Berk, L Madlensky, A Mitri, H Cheng, S Gallinger, Z Cohen and B Bapat. Toronto, Canada

Microsatellite i n s t a b i l i t y i n y o u n g p a t i e n t s w i t h sporadic colorectal cancer. (Abstract# G2380) I Claro, M Cravo, L G16ria, C Gaspar, P Lage, C Albuquerque, P Fidalgo and C Nobre Leit~o. Lisbon, Portugal H e r e d i t a r y m i x e d polyposis s y n d r o m e : loss of heterozygosity i n t u m o r s at t h e I-IMPS locus o n chromosome 6. (Abstract# G2815) M Smedley, CE Cole and RF Jacoby. Madison, WI

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A G A P O S T E R S E S S I O N - - M O N D A Y , MAY 18, 1998 H e r e d i t a r y m i x e d polyposis syndrome: exclusion of genetic l i n k a g e to t h e j u v e n i l e polyposis r e g i o n of c h r o m o s o m e 10. (Abstract# G2857) IPM Tomlinson, CE Cole, RF Jac0by and HJW Thomas. Harrow, United Kingdom and Madison, WI

DDW Poster of Distinction: The gene for f a m i l i a l j u v e n i l e polyposis m a p s to c h r o m o s o m e 18q21. (Abstract# G2520) JR Howe, JC Ringold, RW Summers, FA Mitr0s, DY Nishimura and EM Stone. Iowa City, IA G e r m l i n e PTEN/MMAClfrEP1 m u t a t i o n s a n d association with gastrointestinal manifestations in C o w d e n disease. (Abstract# G2902) HC Weber, D Marsh, I Lubensky, A Lin and C Eng. Boston, MA and Bethesda, MD Colonic a d e n o m a i n Cowden's disease w i t h a g e r m l i n e m u t a t i o n of t h e PTN/MMAC1 t u m o r s u p p r e s s o r gene. (Abstract# G2368) SG Chi, HJ Kim, YW Kim, SH Dong, BH Kim, JI Lee, YW Chang and R Chang. Seoul, Korea Lack of m u t a t i o n s of t h e P T E N t u m o r s u p p r e s s o r gene i n t h r e e B a n n a y a n - R i l e y - R u v a l e a b a s y n d r o m e patients. (Abstract# G2349) JM Carethers, FB Funari, AF Zigman, JE Lavine, MC Jones, GE Graham, AS Teebi, H-JS Huang, DP Chauhan, CL Chang, WK Cavenee and CR Boland. San Diego, CA and Montreal, Canada S t a i n i n g b y Adnab-9, a n a n t i - a d e n o m a antibody, m a y reflect t h e r i s k of n e o p l a s i a i n familial h a m a r t o m a t o n s polyposis s y n d r o m e s . (Abstract# G2852) M Tobi, J Hatfield, S Fligiel, T McGarrity, C Cole and R Jac0by. Detroit, MI; Hershey, PA and Madison, WI Studies i n f a m i l i a l gastric c a n c e r i n t e e n a g e d i d e n t i c a l t w i n s a n d m o t h e r . (Abstract# G2853) M Tobi, M Hamre, J Hass, J Hatfield, S Fligiel, M Alloju, D Begum, P Naylor, T Gallinger, F Berk, B Bapat, M Yuan and V Tolia. Detroit, MI; Toronto, Canada and Beijing, China G A S T R O I N T E S T I N A L ONCOLOGY - - CANCER IN CHRONIC ULCERATIVE COLITIS K-ras a n d p53 gene m u t a t i o n s i n colonic lavage a n d p53 antibodies in serum in long-standinginflammatory bowel disease. (Abstract# G2501) M Heinzlmann, DF Stratakis, SM Lang, C F01waczny, S Urban, S B0rgmann, H Fricke and K L0eschke. Munich, Germany P r o m o t e r h y p e r m e t h y l a t i o n of the t u m o r s u p p r e s s o r gene pl6/INK4A d u r i n g n e o p l a s t i c p r o g r e s s i o n i n u l c e r a t i v e colitis. (Abstract# G2521) CJ Hsieh, B Klump, K Holzmann, F B0rchard, M Gregor and R Porschen. Tuebingen, Germany I m m u n o r e a c t i v e cyclooxygenase-2 expression i n u l c e r a t i v e colitis-associated neoplasms. (Abstract# G2904) A Weiss, N Harpaz, A Chen, A Vergara, N Medalie and S Itzkowitz. New York, NY The s e r u m of digestive, h e p a t i c a n d p a n c r e a t i c c a n c e r p a t i e n t s p o w e r f u l l y activates c a r b o n i c a n h y d r a s e II. R a p i d d i a g n o s i s method. A m u l t i c e n t r i c study. (Abstract# G2743) I Pu~ca~, M Colt~iu, N Ghilezan, T Rfl~ni~l, L Lazfir, V P~lcurar, A Maghiar, O Micle, T Maghiar and I Pop. Simleu Silvaniei, Cluj, Oradea and Zalflu, Romania

Chromosomal i n s t a b i l i t y i n e a r l y u l c e r a t i v e colitis t u m o r i g e n e s i s . (Abstract# G2335) M Bronner, S Ranz, P Rabinovitch, D Crispin, R Haggitt and T BrentnaU. Seattle, WA I n c r e a s e d f o r m a t i o n of oxidative DNA damage i n h u m a n colonic m u c o s a with u l c e r a t i v e colitis. (Abstract# G2699) H Nishibayashi, S Kanayama, Y Shinomura, Y Higashim0t0, J Miyagawa, T Ariyoshi, Y Miyazaki, K Imanishi, M Nakajima, T Takeuchi, K Morimoti and Y Matsuzawa. Osaka, Japan C h a r a c t e r i z a t i o n of the d e x t r a n sulfate s o d i u m - i n d u c e d sequence a c u t e i n f l a m m a t i o n - c h r o n i c i n f l a m m a t i o n associated w i t h dysplasia i n mice. (Abstract# G2593) F Kullmann, T Bocker, H Messmann, V Gross, M Alt, J Rtischoff and J Sch61merich. Regensburg, Germany GASTROINTESTINAL ONCOLOGY - - COLON CANCER S C R E E N I N G UK r a n d o m i s e d c o n t r o l l e d t r i a l of "once only" flexible sigmoidoscopy screening: i n t e r i m results. (Abstract# G2290) WS Atkin, R Edwards, J Cuzick, J Wardle, JMA N0rthover and the MRC FlexiScope Trial Investigators. Harrow and London, United Kingdom I m p o r t a n c e of small a d e n o m a s i n the r e c t o s i g m o i d as p r e d i c t o r s of a d v a n c e d n e o p l a s i a i n the p r o x i m a l colon. (Abstract# G2695) P Netzer, S Schenk, R Neiger, F Halter and A Schmassmann. Bern, Switzerland Is h y p e r p l a s t i c rectal polyp u s e f u l as a m a r k e r for colorectal c a n c e r i n low r i s k p a t i e n t s ? (Abstract# G2294) ER Baba, T Fujii, K Nakamura, S Katoh, T Miyazaki, I Koba, K Hosokawa, SH Park, A Ohtsu, H Tajiri and S Yoshida. Chiba, Japan S e n t i n e l left colonic polyps a n d l y m p h n o d e m e t a s t a s i s i n p a t i e n t s w i t h p r o x i m a l colon c a n c e r are less c o m m o n with a d v a n c i n g age. (Abstract# G2871) A Ukleja, A Nadir and TK Desai. Royal Oak, MI P r e v a l e n c e a n d clinical s i g n i f i c a n c e of p r o x i m a l colorectal a d e n o m a s i n a s y m p t o m a t i c , average-risk subjects. (Abstract# G2307) F Bazzoli, S Fossi, L Ricciardiello, P Pozzato, RM Zagari, D Falli, G Nicolini and E Roda. Bologna and Florence, Italy Should t h e same r u l e s of colonic polyp s u r v e i l l a n c e apply to p a t i e n t s with colorectal c a n c e r after c u r a t i v e resection? (Abstract# G2627) AP Manocha and RE Weesner. Cincinnati, OH Sigmoidoscopy is sufficient for e v a l u a t i o n of "outlet" hematochezia: a t h r e e y e a r o u t c o m e study. (Abstract# G2833) J-L Szpak0wski. Richmond, CA The p r e v a l e n c e of a d e n o m a a n d c a n c e r at s c r e e n i n g colonoscopy c o m p a r e d w i t h colonoscopy d i r e c t e d by a positive Hemoccult ® i n a v e r a g e r i s k a s y m p t o m a t i c adults ages 60-75. (Abstract# G2316) I Bhattacharya and EM Sack. Chicago, IL Costs of s c r e e n i n g colonoscopy for colorectal c a n c e r i n Switzerland. (Abstract# G2306) P Bauerfeind and A Sonnenberg. Ziirich, Switzerland and Albuquerque, NM

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P a t i e n t - c o n t r o l l e d s e d a t i o n u s i n g propofol a n d a l f e n t a n i l d u r i n g colonoscopy: a p r o s p e c t i v e r a n d o m i s e d c o n t r o l l e d trial. (Abstract# G0148) C Roseveare, P Patel, C Seavell, J Criswell, J Kimble, C Jones and H Shepherd. Winchester, United Kingdom C o m p a r i s o n of n u r s e p r a c t i t i o n e r s / p h y s i c i a n a s s i s t a n t s to g a s t r o e n t e r o l o g i s t s i n p e r f o r m i n g flexible sigmoidoscopy. (Abstract# G2889) MB Wallace, KY Ho, Y Trnka, C Henderson, JA Kemp and FA Farraye. Boston, MA W h e n doctors are p a t i e n t s : are we c o m p l i a n t w i t h colorectal c a n c e r screening?. (Abstract# G2328) A Bravo, T Ben-Menachem, R Fogel and S Batra. Detroit, MI

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18, 1998

i[ Fecal c a l p r o t e c t i n levels i n colorectal n e o p l a s i a i n a h i g h risk group. (Abstract# G2588) O Kronborg, M Ugstad, P Fuglerud, J Hardcastle, JH Sch01efield, K Vellacott, V Moshakis and JR Reynolds. Odense, Denmark; Oslo, Norway; Nottingham, Newport, Nuneaton and Derby City, United Kingdom Fecal excretion of c a l p r o t e c t i n i n colorectal cancer. (Abstract# G2587) J Kristinsson, K Nygaard, C Armbruster, S Kriwanek, M Ugstad and P Fuglerud. Oslo and LillestrCm, Norway; Vienna, Austria MOTILITY AND NERVE-GUT I N T E R A C T I O N S - GASTRIC MOTILITY: BASIC S C I E N C E

c a n c e r s c r e e n i n g ? R e s u l t s of a n a t i o n a l survey. (Abstract# G2799) VK Sharma, R Vasudeva and CW Howden. Columbia, SC

Effect of i n t e r l e u k i n - l ~ on e h o l i n e r g i c a n d n i t r e r g i e n e u r o t r a n s m i s s i o n i n the r a t g a s t r i c f u n d u s . (Abstract# G3314) TG M0reels, JG De Man, BY De Winter, AG Herman and PA Pelckmans. Antwerp, Belgium

Psychosocial factors i n f l u e n c i n g the a c c e p t a n c e of colon c a n c e r s c r e e n i n g . (Abstract# G2732) IE Pladdet, S Kremers, W Hameeteman, I Mesters, HW vd Borne and RW Stockbriigger. Maastricht, The Netherlands

Chemical coding of vagal s e c r e t i n r e c e p t o r s to m e d i a t e gastric r e l a x a t i o n evoked by secretin. (Abstract# G3277) Y Lu, JX Zhu, Y Li, Y Tsunoda and C Owyang. Ann Arbor, MI

D o p r i m a r y care p h y s i c i a n s u n d e r s t a n d colorectal

P r o t e c t i v e effect of fecal occult blood test s c r e e n i n g for colorectal cancer: worse p r o g n o s i s for s c r e e n i n g refusers. (Abstract# G2700) Y Niv, M Lev-E1, G Fraser and A Tamir. Tel Aviv and Technion, Israel I m m u n o c h e m i c a l fecal occult blood test for d e t e c t i o n of r e c t o s i g m o i d c a n c e r i n a s y m p t o m a t i c adults. (Abstract# G2570) YH Kim, J Kim, HJ Son, PL Rhee, KC Koh, SW Paik, JC Rhee and KW Choi. Seoul, Korea D e t e c t i o n of K-ras/p53 m u t a t i o n s i n stool specimens of p a t i e n t s w i t h colorectal cancer. (Abstract# G2498) T Hatt0ri, N Kaminaga, Y Endo, H Takahashi and R Fujita. Kanagawa, Japan High f r e q u e n c y of d e t e c t i n g amplifiable DNA i n stools of a p p a r e n t l y n o r m a l i n d i v i d u a l s . (Abstract# G2813) JE Skoletsky and AP Shuber. Maynard, MA M o r p h o m e t r i c a n a l y s i s of the '~nucocellular layer" o v e r l y i n g colorectal c a n c e r a n d n o r m a l mucosa: r e l e v a n c e to exfoliated stool s c r e e n i n g m a r k e r s . (Abstract# G2269) DA Ahlquist, JJ Harrington, LJ Burgart and PC Roche. Rochester, MN I n t e r f e r e n c e of fecal colonocyte r e c o v e r y b y e n d o g e n o u s cytolysis. (Abstract# G2495) JJ Harrington, PJ Limburg, PC Roche, GG Klee, V Simko and DA Ahlquist. Rochester, MN and Brooklyn, NY G u i d e l i n e s for a n a l cytology - to m a k e cytological diagnosis a n d follow-up m u c h m o r e reliable. (Abstract# G2787) J Scholefield and J Johnson. Nottingham, United Kingdom E v a l u a t i o n of s e n s i t i v i t y a n d specificity of CD44 e x p r e s s i o n i n fecal colonocytes as a n o n i n v a s i v e m a r k e r for d e t e c t i n g colonic polyps a n d cancer. (Abstract# G2377) KY Chung, T Mullick, M Motevalli, S Vinayek, UK Tantry, PP Nair and SK Dutta. Baltimore and Beltsville, MD

II

I n c r e a s e d w o r m e x p u l s i o n a n d vagal r e s p o n s e to gastric d i s t e n t i o n following T. spiralis i n f e c t i o n i n a r a t model of cholinergic h y p e r - r e s p o n s i v e n e s s . (Abstract# G3519) L Wang, V Djuric, PA Blennerhassett, M Steiner, DH Overstreet, SM Collins and G Tougas. Hamilton, Canada and Chapel Hill, NC Are the i m p a i r e d c o n t r a c t i l e r e s p o n s e s of d i a b e t i c a n t r a l c i r c u l a r muscle due to a n a l t e r e d s m o o t h muscle contractile m e c h a n i s m ? (Abstract# G3530) HF Wrz0s, R P01avarapu and A Ouyang. Hershey, PA Effect of p r e g n a n c y on c o n t r a c t i o n of isolated s m o o t h muscle cells from g u i n e a pig p r o x i m a l stomach. (Abstract# G3179) A James, HP Parkman, S Driska and JP Ryan. Philadelphia, PA P o t e n t gastric m o t o r a n d c a r d i o v a s c u l a r r e s p o n s e s to i n t r a v e n o u s l y a d m i n i s t e r e d n o c i c e p t i n i n t h e rat. (Abstract# G3163) PJ H0rnby, DR Kapusta and ZK Krowicki. New Orleans, LA Influence of diabetes m e l l i t u s o n t h e c o n t r a c t i l e activity of g a l a n i n i n the r a t i s o l a t e d gastric f u n d u s strips. (Abstract# G3215) R Kor01kiewicz, Z Konstanskl, P Rekowski, A Szyk, S Kato, T Yasuhiro, M Kub0mi and K Takeuchi. Ky0to, Japan and Gdansk, Poland Effect of gastric electrical s t i m u l a t i o n o n g a s t r i c contractions, myoelectrical a c t i v i t y a n d e m p t y i n g d u r i n g p o s t o p e r a t i v e ileus i n dogs. (Abstract# G3211) KL Koch, L Xu, R Wilson, D Eggli and G Kauffman. Hershey, PA Effector site of giueagon i n r a t stomach: possible i n t e r a c t i o n w i t h i n t e r s t i t i a l cells of Cajal. (Abstract# G3207) H Kishikawa, M Nakamura, Y Akiba, S Miura, M Oda and H Ishii. Tokyo, Japan P e p t i d e YY i n c r e a s e s gastric e m p t y i n g i n rats. (Abstract# G2982) V Bicheler, C Cherbut, A Ropert, C Roz~ and JP Galmiche. Nantes, Rennes and Paris, France

April1998

PROGRAM OF THE ANNUALMEETINGP79

A G A P O S T E R S E S S I O N m M O N D A Y , M A Y 18, 1998 Area p o s t r e m a lesions block the r e g u l a t i o n of gastric e m p t y i n g b y a m y l i n . (Abstract# G3088) GL Edwards, BR Gedulin, C Jedka, RP Dilts, CC Miller and A Young. Athens, GA and San Diego, CA The h e r b a l m e d i c i n e , Dai-Kenchu-To, s t i m u l a t e s u p p e r GI m o t i l i t y i n conscious dogs via cholinergic a n d 5-HTs receptors. (Abstract# G3437) C Shibata, I Sasaki, H Naito, N Ohtani, T Uen0, Y Funayama, K Fukushima and S Matsuno. Sendal, Japan E n t e r i c n e u r a l r e g u l a t i o n of pyloric s p h i n c t e r function. (Abstract# G3364) HP Parkman, AP Pagano, RM Thomas and JP Ryan. Philadelphia, PA C o m p u t e r model for artificial a c c e l e r a t i o n of liquid gastric e m p t y i n g i n dogs. (Abstract# G3308) MP Mintchev, CP Sanmiguel and KL Bowes. Alberta and Calgary, Canada

DDW Poster of Distinction: Myoelectric a c t i v i t y i n the h u m a n f u n d u s . (Abstract# G3420) B Schirmer and R Neff. Charlottesville, VA

DDW Poster of Distinction: N o r m a l i z a t i o n of a t r o p i n e - i n d u c e d gastric myoelectrical d y s r h y t h m i a w i t h gastric pacing. (Abstract# G3381) LW Qian, XM Lin and JDZ Chen. Oklahoma City, OK Effects of e l e c t r o a c u p u n c t u r e o n gastric motility i n dogs. (Abstract# G3380) LW Qian, M Zhang, LJ Peters and JDZ Chen. Oklahoma City, OK

DDW Poster of Distinction: Effective p a c i n g p a r a m e t e r s for the e n t r a i n m e n t of g a s t r o i n t e s t i n a l slow waves i n dogs. (Abstract# G3257) XM Lin, M Zhang, JDZ Chen and LJ Peters. Oklahoma City, OK

Gastric e m p t y i n g of l i q u i d s a n d p o s t p r a n d i a l p a n c r e a t o b i l i a r y s e c r e t i o n are t e m p o r a r i l y i m p a i r e d d u r i n g endotoxemia. (Abstract# G3054) JJ Cullen, S Titler, KS Ephgrave and MM Hinkhouse. Iowa City, IA I n v e s t i g a t i o n s o n a 5-HT4 a g o n i s t ( S D Z H T F 9 1 9 ) a n d its m a i n m e t a b o l i t e i n conscious dogs: effects o n g a s t r o i n t e s t i n a l m o t i l i t y a n d i m p a i r e d gastric emptying. (Abstract# G3103) J Fioramonti, M Million and L Bueno. Toulouse, France I n f l u e n c e of fundic d i s t e n s i o n o n f a s t i n g a n t r o d u o d e n a l m a n o m e t r i c p a t t e r n s i n m a n . (Abstract# G3374) H Piessevaux, J Tack, A Geubel and J Janssens. Leuven and Brussels, Belgium Effect of b a c t e r i a l p e r i t o n i t i s i n the lower a b d o m i n a l cavity o n recovery of g a s t r o i n t e s t i n a l m o t i l i t y following laparoscopic surgery. (Abstract# G3178) M Ishikawa, MC Blair, RS Neff, M Ishikawa and BD Schirmer. Charlottesville, VA Relative c o n t r i b u t i o n of ' ~ r e s s u r e p u m p " a n d ' ~ e r i s t a l t i c p u m p " to gastric e m p t y i n g . (Abstract# G3173) K Indireshkumar, H Faas, JG Brasseur, GS Hebbard, P Kunz, J Dent, P Boesiger, C Feinle, M Fried, M Li and W Schwizer. University Park, PA; Z~irich, Switzerland and Adelaide, Australia Variables affecting t h e difference i n r a t e of gastric e m p t y i n g a m o n g subjects. (Abstract# G3174) K Indireshkumar, JG Brasseur, H Faas, GS Hebbard, P Kunz, J Dent, P Boesiger, C Feinle, M Fried and W Schwizer. University Park, PA; Z~irich, Switzerland and Adelaide, Australia Glucagon-like peptide-1 is a p o w e r f u l i n h i b i t o r of gastric e m p t y i n g i n m a n . (Abstract# G3329) E N~islund, S Skogar, P Gryb~ck, H Jacobsson, JJ Holst and PM Hellstr~m. Stockholm, Sweden and Copenhagen, Denmark

Effect of stress o n p o s t p r a n d i a l gastric myoelectrical activity a n d role of p a r a s y m p a t h e t i c activity. (Abstract# (33025) JDZ Chen, D Levanen, XP Zou, J Liang and WC Orr. Oklahoma City, OK

Does Helieobaeterpylori associated gastritis i n f l u e n c e m o t o r f u n c t i o n of t h e p r o x i m a l s t o m a c h i n dyspeptic p a t i e n t s ? (Abstract# G3495) PJ van der Schaar, MK Vu, AMC Witte, JWA Straathof, RA Veenendaal, CBHW Lamers and AAM Masclee. Leiden, The Netherlands

Effect of p a c i n g p u l s e w i d t h o n the e n t r a i n m e n t of gastric slow waves i n h u m a n s . (Abstract# G3260) ZY Lin, RW McCallum, BD Schirmer and JDZ Chen. Kansas City, KS; Charlottesville, VA and Oklahoma City, OK

Effect of h y p e r i n s u l i n e m i a a n d h y p e r g l y c e m i a on p r o x i m a l gastric m o t o r f u n c t i o n . (Abstract# G3502) AS van Petersen, MK Vu, WF Lam, CBHW Lamers, J Ringers and AAM Masclee. Leiden, The Netherlands

MOTILITY AND N E R V E - G U T INTERACTIONS - GASTRIC MOTILITY: CLINICAL SCIENCE

G a s t r o i n t e s t i n a l s y m p t o m s after t r a n s p l a n t a t i o n . (Abstract# G3321) K Mullins, M DeMeo, A Keshavarzian, T Murphy, S Fisher, E Garrity, M Mullen, R Lewis and M Bakhos. Maywood, IL

Effect of m e t o c l o p r a m i d e o n gastric myoelectrical activity i n p a t i e n t s w i t h gastroparesis. (Abstract# G3259) ZY Lin, RW McCallum, BD Schirmer and JDZ Chen. Kansas City, KS; Charlottesville, VA and Oklahoma City, OK

Gastroparesis a n d a u t o n o m i c d y s f u n c t i o n i n cirrhosis. (Abstract# G3509) GN Verne, C Soldevila-Pico, KM Spicer and A Reuben. Gainesville, FL and Charleston, SC

P r o x i m a l gastric m o t o r f u n c t i o n i n reflux disease a n d after l a p a r o s c o p i c f u n d o p l i c a t i o n . (Abstract# G3515) MK Vu, PJ van der Schaar, JWA Straath0f, CBHW Lamers and AAM Masclee. Leiden, The Netherlands Postprandial power change in electrogastrogram correlates w i t h g a s t r i c e m p t y i n g i n h u m a n s . (Abstract# G3261) ZY Lin, EY Eaker and RW McCallum. Kansas City, KS

The effect of m u l t i p l e doses of KC 11458, a n e w m o t i l i n agonist, o n gastric e m m p t y i n g of a solid test meal i n h e a l t h y male v o l u n t e e r s . (Abstract# G3456) H Steinbrede, S Aygen, G Eibes and C Steinb0rn. B0chum and Hannover, Germany

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POSTER

GASTROENTEROLOGYVol. 114rNo. 4 SESSION

Gastric e m p t y i n g i n p a t i e n t s w i t h n o n - i n s u l i n d e p e n d e n t d i a b e t e s before a n d after t h e r a p y r e a d j u s t m e n t : n o i n f l u e n c e of glycemic c o n t r o l a n d blood glucose level. (Abstract# G3162) A Holz~pfel, A Festa, G Stacher-Janotta, H Bergmann and G Stacher. Vienna, Austria Gastric e m p t y i n g i n n o r m a l weight, obese a n d severely obese children. (Abstract# G3027) M Chiloiro, M Caroli, S Cucchiara, V Guerra and G Riezzo. Bari, Brindisi and Naples, Italy Is t h e r e a r e l a t i o n s h i p b e t w e e n g a s t r i c electrical a b n o r m a l i t i e s a n d g a s t r o e s o p h a g e a l reflux? (Abstract# G3410) CP Sanmiguel, MP Mintchev and KL Bowes. Alberta and Calgary, Canada Does IV o n d a n s e t r o n affect gastric e m p t y i n g of a solid m e a l i n h e a l t h y v o l u n t e e r s ? (Abstract# G3U0) C Gaia, C Gaia, U Scheurer, S Lourens, P Reber, S Wildi, U Noelpp, E-P Ritter, H Ledermannm, D Li~scher, JA Kinser, W Uhl and MW B~ichler. Bern, Switzerland Active d u o d e n a l u l c e r is associated w i t h prolonged o p e n i n g of t h e pylorus, i n c r e a s e d r e t r o g r a d e t r a n s p y l o r i c flow a n d d e l a y e d g a s t r i c emptying. (Abstract# G3355) N Pallotta, M Cicala, C Frandina, G D'Ambra, M Paoletti, A Bertolotti and E Corazziari. Rome, Italy R e l a t i o n s h i p b e t w e e n a n t r a l a n d p y l o r i c m o t o r activity after i n g e s t i o n of a n u t r i e n t meal. (Abstract# G3357) N Pallotta, M Cicala, C Frandina and E Corazziari. Rome, Italy A n t r a l c o n t r a c t i l e p a t t e r n s after n u t r i e n t a n d nonn u t r i e n t l i q u i d meals. (Abstract# G3356) N Pallotta, M Cicala, C Frandina and E Corazziari. Rome, Italy Coffee h a s n o effect o n gastric e m p t y i n g or orocecal t r a n s i t time. (Abstract# G2989) PJ Boekema, B Lo, M Samsom, LMA Akkermans and AJPM Smout. Utrecht, The Netherlands D o m p e r i d o n e i m p r o v e s g a s t r o i n t e s t i n a l symptoms a n d glycemic c o n t r o l i n d i a b e t e s m e l l i t u s p a t i e n t s with s y m p t o m s of d i a b e t i c g a s t r o p a t h y . (Abstract# G2938) TL Abell, H Rashed and M Adl. Memphis, TN Long t e r m follow-up of obesity s u r g e r y - a u t o n o m i c a n d e n t e r i c n e r v o u s s y s t e m p r e d i c t o r s a t b a s e l i n e are i m p o r t a n t . (Abstract# G3544) TL Abell, M Tabbaa, H Rashed, S Cardoso, J Famfloni, C Burlington and G Cowan. Memphis, TN I n f l u e n c e of O r l i s t a t o n gastric e m p t y i n g r a t e s of fat a n d solids i n h e a l t h y subjects. (Abstract# G3057) L Degen, D Matzinger, H Maecke, H Lengsfeld and C Beglinger. Basel, Switzerland D o m p e r i d o n e is s u p e r i o r to c i s a p r i d e i n the t r e a t m e n t of gastric e m p t y i n g delay a n d g a s t r i c d y s r h y t h m i a s i n c h i l d r e n w i t h diabetes mellitus. (Abstract# G3051) S Cucchiara, A Franzese, MT Franco, G Salvia, O Borrelli, S Fecarotta and L Alfonsi. Naples, Italy Gastric e m p t y i n g a n d electrical a c t i v i t y i n p r e t e r m n e w b o r n s a s s u m i n g different m i l k formulas. (Abstract# G3393) G Riezzo, F Indrio, O Montagna, C Tripaldi, N Laforgia, L De Cosmo, M Chiloiro and A Mautone. Bari, Italy

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MAY

18, 1998

Gastric myoelectrical a c t i v i t y after cervical s p i n a l cord i n j u r y . (Abstract# G3273) CL Lu, P Montgomery, XP Zou and JDZ Chen. Oklahoma City, OK Exercise e n h a n c e s p o s t p r a n d i a l g a s t r i c m y o e l e c t r i c a l activity. (Abstract# G3272) CL Lu, N Shidler and JDZ Chen. Oklahoma City, OK Gastric a n d small bowel d y s f u n c t i o n i n p a t i e n t s w i t h a n t r a l hypomotility: r e s p o n s e to e r y t h r o m y c i n a n d octreotide. (Abstract# G3540) E Zayat, SY Yu, SB Von Miiller, VA Schettler-Duncan, MM Schuster and MD Crowell. Baltimore, MD Gastric e m p t y i n g i n c h i l d r e n w i t h e x t r e m e s h o r t gut syndrome. (Abstract# G3339) S Ohwada, T Ishii, J Bueno, L Sigurdsson, M Charr0n, S Kocoshis, G Mazariegos and J Reyes. Pittsburgh, PA Gastric emptying, pH a n d m o t i l i t y after s e g m e n t a l gastrectomy. (Abstract# G3413) Y Sato, S Ohwada, 0 Kawamura, N Oriuchi, T Ogawa and Y Morishita. Maebashi, Japan Effect of n i t r i c oxide d o n o r m o l s i d o m i n e o n gastric e m p t y i n g i n h u m a n s . (Abstract# G3462) C Strasser, J Barnett, M Nowakowski and M Wienbeck. Augsburg, Germany and Krakow, Poland The effect of r e d p e p p e r a n d c a p s a i c i n o n gastric e m p t y i n g i n h u m a n volunteers. (Abstract# G3361) HJ Park, SK Na, SI Lee, JK Kang and IS Park. Seoul, Korea The gastric m o t o r f u n c t i o n i n gastric c a n c e r a n d its c o r r e l a t i o n of c-kit d e n s i t y i n c i r c u l a r m u s c l e layer. (Abstract# G3362) HJ Park, JH Kim, SI Lee, JK Kang and IS Park. Seoul, Korea Effect of levosulpiride o n e l e c t r o g a s t r o g r a m i n p a t i e n t s w i t h f u n c t i o n a l dyspepsia. (Abstract# G2975) G Bazzocchi, C Diquattro, E Conti, M Balloni, SN Reddy, S Reggiani, D Ravaglia and PR Dal Monte. Bologna, Italy and Hyderabad, India Is gastric myoelectric activity associated w i t h s y m p t o m s i n p a t i e n t s w i t h f u n c t i o n a l dyspepsia? (Abstract# G2954) BM Attar, MV Demetria and J Chen. Chicago, IL and Oklahoma City, OK MOTILITY AND NERVE-GUT I N T E R A C T I O N S - GASTRIC MOTOR F U N C T I O N T E S T S

DDW Poster of Distinction: T h r e e - d i m e n s i o n a l m a g n e t i c r e s o n a n c e i m a g i n g of the i n t r a g a s t r i c d i s t r i b u t i o n of the fat c o m p o n e n t of a solid meal i n h u m a n s . (Abstract# G3102) C Feinle, P Kunz, H Faas, P B0esiger, M Fried and W Schwizer. Ziirich, Switzerland N o n i n v a s i v e echo-planar i m a g i n g m o n i t o r i n g of i n t r a g a s t r i c viscosity, d i l u t i o n a n d e m p t y i n g of viscous meals i n n o r m a l subjects. (Abstract# G3282) L Marciani, J Wright, P Manoj, RJ Moore, P Young, D Bush, S A1-Sahab, A Fillery-Travis, PA Gowland and RC Spiller. Nottingham and Norwich, United Kingdom

PROGRAMOFTHEANNUALMEETINGPS1

April1998

A G A P O S T E R S E S S I O N - - M O N D A Y , MAY 18, 1998 E r y t h r o m y c i n - i n d u c e d a l t e r a t i o n s to antro-pyloroduodenal motility studied by combined manometry and MRI. (Abstract# G3095) H Faas, GS Hebbard, P Kunz, JG Brasseur, C Feinle, K Indireshkumar, M Li, J Dent, P B0esiger, M Fried and W Schwizer. Ziirich, Switzerland; Philadelphia, PA and Adelaide, Australia

19C-octanoic acid b r e a t h test for g a s t r i c e m p t y i n g of solids: meal-to-meal v a r i a b i l i t y . (Abstract# G3152) P Hildebrand, J Drewe, LP Degen and C Beglinger. Basel, Switzerland

DDW Poster of Distinction:

F u r t h e r v a l i d a t i o n of t h e lSC-octanoic acid b r e a t h test for gastric e m p t y i n g of solids. (Abstract# G3075) J Drewe, P Hildebrand, L Descl0ux and C Beglinger. Basel, Switzerland

A n electric i m p e d a n c e system detects a n t r o p y l o r i c motility. (Abstract# G3234) H-R Lee, CM Prather, SF Phillip, L Heyl and CS Clark. Rochester, MN and Denver, CO

A n a l t e r n a t i v e model for the e s t i m a t i o n of gastric h a l f e m p t y i n g time (Tso) of a solid m e a l u s i n g the xscoctanoic acid b r e a t h test. (Abstract# G3390) A Raychaudhuri, V Shu and M Verlinden. Chicago, IL

DDW Poster of Distinction:

xaC-octanoic a n d -acetate b r e a t h tests m e a s u r e the gastric e m p t y i n g of solids a n d liquids: p r a c t i c a b i l i t y a n d e v a l u a t i o n of p a r a m e t e r s . (Abstract# G3001) B Braden, H-J Karich, CF Dietrich, WF Caspary and B Lembcke. Frankfurt, Germany

T w o - l u m e n t u b i n g is r e q u i r e d for a c c u r a t e b a r o s t a t studies. (Abstract# G3471) T Tam, H Mui, S Jundler, G Tougas and D Armstrong. Hamilton and Toronto, Canada Detection of slow wave p r o p a g a t i o n from c u t a n e o u s e l e c t r o g a s t r o g r a m . (Abstract# G3543) XP Zou, J Liang and JDZ Chen. Oklahoma City, OK N o n i n v a s i v e m e a s u r e m e n t of gastric p r o p a g a t i o n u s i n g a m u l t i c h a n n e l SQUID m a g n e t o m e t e r . (Abstract# G3003) LA Bradshaw, JK Ladipo, CD Haupt, SA Seidel, P Van Leeuwen, JP Wikswo, Jr and WO Richards. Nashville, TN; San Diego, CA and Bochum, Germany 24-hour a m b u l a t o r y m a n o m e t r y of t h e a n t r o - d u o d e n a l tract: p r e l i m i n a r y r e s u l t s of a l a r g e group of h e a l t h y subjects. (Abstract# G2994) M Bortolotti, V Annese and G Coccia. Bologna, Foggia and Genoa, Italy T r e a t m e n t of severe C r o h n ' s disease u s i n g r i f a b u t i n macrolide-clofazimine c o m b i n a t i o n : i n t e r i m report. (Abstract# G3842) TJ B0r0dy, L Pearce, PA Bampton and S Leis. Sydney, Australia Spatial a n d t e m p o r a l v a r i a t i o n s i n t h e m a g n e t i c fields p r o d u c e d b y h u m a n g a s t r o i n t e s t i n a l activity. (Abstract# G3486) GK Turnbull, G Stroink, SP Ritcey, B Brandts and P van Leeuwen. Halifax, Canada and B0chum, Germany E l e c t r o g a s t r o g r a p h y differentiates b e t w e e n g a s t r o s t o m y t u b e f e e d i n g - i n t o l e r a n t versus -tolerant c h i l d r e n . (Abstract# G3147) JB Heikenen, SL Werlin, CW Brown and SN Reddy. Milwaukee, WI and Long Beach, CA The effect of t h e r e s i n (amberlite) o n gastric e m p t y i n g s c i n t i g r a p h y . (Abstract# G3369) HC Park, CW Song, CD Kim, HS Ryu, JG Choi and JH Hyun. Inchon and Se0ul, Korea Vector m a g n e t o g a s t r o g r a p h y : t h e gastric slow wave vector. (Abstract# G3429) SA Seidel, LA Bradshaw, JK Ladipo, JP Wikswo, Jr and WO Richards. Nashville, TN E v a l u a t i o n of gastric e m p t y i n g b y m e a s u r e m e n t of p r o p o r t i o n of i n t r a - a b d o m i n a l r a d i o a c t i v i t y i n stomach. (Abstract# G3251) HC Lien, CS Chang, GH Chen, CH Kao, SC Tsai and SJ Wang. Talchung, Taiwan Diagnostic i m p a c t of e l i m i n a t i n g EGG m o t i o n artifacts u s i n g n e u r a l n e t w o r k s . (Abstract# G3250) HC Lien, JC Fu, CH Tsai and CA Troy. Taichung, Taiwan

N o n i n v a s i v e 13C-octanoic acid b r e a t h test shows d e l a y e d gastric e m p t y i n g i n p a t i e n t s w i t h a m y o t r o p h i c l a t e r a l sclerosis. (Abstract# G3478) M Toepfer, RL Riepl, W Miiller-Felber, S Endres and C Folwaczny. Munich, Germany H o w a c c u r a t e is the m e a s u r e m e n t of gastric e m p t y i n g of solids b y 13C-octanoic acid b r e a t h t e s t i n

s y m p t o m a t i c diabetic p a t i e n t s ? (Abstract# G3235) J-S Lee, M-G Choi, DD Burton, KS Nair, M Verlinden, CA Olson and M Camilleri. Rochester, MN and Abbott Park, IL Dose-dependent effect of cisapride o n orocecal t r a n s i t s t u d i e d b y the lactose 13C-ureide b r e a t h test. (Abstract# G3115) B Geypens, P Evenepoel, Y Gh00s and P Rutgeerts. Leuven, Belgium C o r r e l a t i o n of ileal e m p t y i n g a n d g a s t r i c e m p t y i n g c a l c u l a t e d from a s i m u l t a n e o u s a p p l i c a t i o n of two b r e a t h tests. (Abstract# G3U4) B Geypens, B Maes, Y Ghoos, A Luypaerts and P Rutgeerts. Leuven, Belgium Direct d e m o n s t r a t i o n of the effect of lactulose on colonic b a c t e r i a l m e t a b o l i s m b y a p p l i c a t i o n of lactose(15N)-ureide. (Abstract# L0196) B Geypens, P Evenep0el, M Peeters, A Luypaerts, P Rutgeerts and Y Ghoos. Leuven, Belgium The lactose 13C-ureid b r e a t h test: also applicable i n y o u n g children? (Abstract# G3494) M Van Den Driessche, N Van Malderen, B Geypens, Y Gh00s and G Veereman-Wauters. Leuven, Belgium MOTILITY AND N E R V E - G U T I N T E R A C T I O N S - SMALL I N T E S T I N E MOTILITY: BASIC SCIENCE

DDW Poster of Distinction: G-protein a c t i v a t e d c o n t r a c t i o n s i n n o r m a l a n d i n f l a m e d ileum. (Abstract# G3406) S Sakamoto, CP Johnson, MB Adams and SK Sarna. Milwaukee, WI I n h i b i t i o n of gastric m o t i l i t y b y ileal s h o r t c h a i n f a t t y acids is m e d i a t e d b y a n h u m o r a l p a t h w a y only. (Abstract# G3052) G Cuche and CH Malbert. St Gilles, France

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I n h i b i t i o n of m i g r a t i n g myoelectric complex by glucagon-like peptide-1 (7-36)amide, b u t n o t glucagon, is m e d i a t e d via t h e GLP-1 receptor, p a r t i a l l y d e p e n d e n t o n n i t r e r g i c m e c h a n i s m s . (Abstract# G3479) T Tolessa, M Gutniak, S Efendic and PM HeUstr6m. Stockholm, Sweden S e r o t o n i n i n d u c e s p h a s e III of the MMC, via 5-HT3r e c e p t o r s d e p e n d e n t o n cholinergic m e c h a n i s m s i n t h e small i n t e s t i n e . (Abstract# G3271) M L6rdal and PM Hellstr6m. Stockholm, Sweden T u m o r necrosis factor-a i n d u c t i o n precedes n i t r i c oxide s y n t h a s e II i n t h e s m a l l i n t e s t i n e of r a t s t r e a t e d w i t h lipopolysaccharide. (Abstract# G2952) R Arya, B Grossie, M Lai and NW Weisbr0dt. Houston, TX Effects of c h r o n i c t r e a t m e n t w i t h a n t i d e p r e s s a n t s o n i n v / t r o j e j u n a l c o n t r a c t i l i t y i n rats. (Abstract# G3111) R Garcia-Villar, C Picard, F Frenois, J Fi0ram0nti and L Bu~no. Toulouse, France Non-adrenergic non-cholinergic inhibition in l o n g i t u d i n a l s m o o t h m u s c l e of r a t j e j u n u m : m i n o r role of n i t r i c oxide. (Abstract# G2963) BM Balsiger, N Ohtani, C Shibata and MG Sarr. Rochester, MN

GROWTH, DEVELOPMENT, N U T R I T I O N - NUTRITION: BASIC SCIENCE

DDW Poster of Distinction: R e g u l a t o r y m e c h a n i s m of oligopeptide t r a n s p o r t e r expression b y e n t e r a l n u t r i t i o n a l deficiency a n d a d a p t a t i o n i n rats. (Abstract# G3624) T Ihara, T Tsujikawa, K Uda, Y Fujiyama and T Bamba. Shiga, Japan

DDW Poster of Distinction: Alterations i n s o d i u m glucose c o t r a n s p o r t e r gene expression i n g l u t e n e n t e r o p a t h y . (Abstract# G3748) GE Wild, J Hasan, MJ Ropeleski, J McCann and ABR Thomson. Edmonton, Canada Hyposecretion of b i l i a r y p h o s p h o l i p i d s s i g n i f i c a n t l y decreases the i n t e s t i n a l a b s o r p t i o n of cholesterol i n Mdr2 (-/-) a n d (+/-) mice. (Abstract# G3744) DQ-H Wang, F Lammert, B Paigen and MC Carey. Boston, MA and Bar Harbor, ME Isolation a n d c h a r a c t e r i z a t i o n of t h e i n t e s t i n a l triacylglycerol t r a n s p o r t vesicle. (Abstract# G3651) NS Kumar and CM Mansbach. Memphis, TN

Motor p a t t e r n s i n a n isolated a r t e r i a l l y p e r f u s e d small i n t e s t i n e of the mouse. (Abstract# G2998) L Bouley, P Duteit, UA Meyer and P Kucera. Lausanne and Basel, Switzerland

E x p r e s s i o n a n d d i s t r i b u t i o n of cytosolic ~-glucosidase i n the h u m a n i n t e s t i n a l tract. (Abstract# G3546) AN Awan, WS Hays, M Jamal, S Ar0ra, RH Glew and DE Johnston. Albuquerque, NM

Intestinal pacing increases intestinal contractility in dogs. (Abstract# G3249) J Liang and JDZ Chen. Oklahoma City, OK

A s t u d y of the u p t a k e a n d l y m p h a t i c t r a n s p o r t of l i p i d i n the mouse. (Abstract# G3756) S Zheng, LEe, L Yao, D Hui and P Ts0. Cincinnati, OH

Effects of d u o d e n a l d i s t e n s i o n o n gastric a n d i n t e s t i n a l myoelectrical activities. (Abstract# G3248) J Liang, LW Qian, XP Zou and JDZ Chen. Oklahoma City, OK

A s t u d y of the u p t a k e a n d l y m p h a t i c t r a n s p o r t of l i p i d i n the s u c k l i n g rat. (Abstract# G3596) LEe, S Zheng, L Yao, X Qin and P Ts0. Cincinnati, OH

I n v o l v e m e n t of 5-HTa/5-HT4 r e c e p t o r s i n t e r a c t i o n s i n t o t a l i n t e s t i n a l t r a n s i t of stressed rats. (Abstract# G3270) Y L0pez, P Pichat and I Angel. Ruefl-Malmaison, France TNBS-induced i n f l a m m a t i o n i m p a i r s organized myoelectric a c t i v i t y i n t h e r a t small i n t e s t i n e . (Abstract# G3062) I Demedts, J Tack, A Andri01i and J Janssens. Leuven, Belgium Effect of diabetes a n d a g i n g o n g a s t r o i n t e s t i n a l m o t i l i t y i n the rat. (Abstract# G3060) I Demedts, J Tack, A Andrioli and J Janssens. Leuven, Belgium I m p a i r m e n t of i n t e s t i n a l m o t i l i t y following b u r n i n j u r y i n rats: role of e n d o t h e l i n s . (Abstract# G3488) E ~Inliier, | Alican, B~ Yemen and C Yemen. Istanbul, Turkey Viscosity a n d p a r a m e t e r s of the p e r i s t a l t i c reflex i n the isolated g u i n e a p i g ileum. (Abstract# G3229) M Lars0n, T Wolf and K Schulze-Delrieu. Iowa City, IA P - t o l y m e t h y l c a r b i n o l - n i c o t i n a t ei n h i b i t s peristalsis i n g u i n e a pig ileum. (Abstract# G3372) T Petnehazy, S Scheidl, R Gasser, K Bliimlinger, GJ Krejs and HF Hammer. Graz, Austria N o r m a l b a s a l m o t i l i t y a n d e n h a n c e d cholinergic r e a c t i v i t y of t h e j e j u n u m i n n e m a t o d e - i n d u c e d h y p e r m a s t o c y t o s i s i n rats. (Abstract# G3U2) J Gay, J Fioram0nti, R Garcia-Villar and L Bu~no. Toulouse, France

DDW Poster of Distinction: H u m a n milk i n h i b i t s oxidative s t r e s s - i n d u c e d d i s r u p t i o n of the CaCo-2 epithelial b a r r i e r function. (Abstract# G3706) ILK Ra0, RD Baker, SS Baker, C Wagner and A Schlutor. Charleston, SC C y t o k i n e - i n d u c e d GRO/CINC-1 p r o d u c t i o n of i n t e s t i n a l epithelial cells is s i g n i f i c a n t l y e n h a n c e d b y f a t t y acid absorption. (Abstract# G3753) H Yoshida, S Miura, H Kishikawa, M Hirokawa, T Takeuchi, T Shigematsu, RC Nakatsumi, H Kimura, H Suzuki, H Saito and H Ishii. Tokyo, Japan Molecular c h a r a c t e r i z a t i o n of the h u m a n fecal flora u s i n g rRNA-targeted h y b r i d i z a t i o n probes. (Abstract# G3697) P Pochart, G Gramet, I G0derel and J D0r~. J0uy-en-Josas and Paris, France Coexistence of m e t h a n o g e n s a n d sulfate r e d u c i n g b a c t e r i a i n the colon of h u m a n m e t h a n e - e x c r e t o r . (Abstract# G1652) P Pochart, H Kroczynski and J Dord. Jouy en Josas, France

DDW Poster of Distinction: Evidence for r a p i d t r a n s l a t i o n a l u p r e g u l a t i o n of i n t e s t i n a l a p o l i p o p r o t e i n A-IV b y d i e t a r y fat. (Abstract# G3637) TJ Kalogeris, RG Painter and VR Holden. Shreveport, LA

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R e d u c e d e x p r e s s i o n of t h e i n t e s t i n a l t r a n s c r i p t i o n factors CDX2 a n d C/EBP~ i n r a t s fed b y total p a r e n t e r a l n u t r i t i o n . (Abstract# G3620) A Howard, N Barley, M J0rdinson, RA G00dlad and JRF Walters. London, United Kingdom

R e d u c e d gut c i t r u l l i n e p r o d u c t i o n does not lead to r e d u c e d r e n a l a r g i n i n e p r o d u c t i o n after e n d o t o x i n t r e a t m e n t i n t h e rat. (Abstract# G3616) MM HaUemeesch, DCP Cobben, NEP Deutz and PB Soeters. Maastricht, The Netherlands

DDW Poster of Distinction:

G e r m i n a t e d b a r l e y footstuff i n d u c e s b u t y r a t e production and enhances mucosal barrier function in the colon o f e x p e r i m e n t a l colitis. (Abstract# G3638) O Kanauchi, K Mitsuyama, T Saiki, K Tanikawa and T Iwanaga. Gunma, Kurume and Sapporo, Japan

B u t y r a t e r e g u l a t e s c h e m o k i n e secretion by i n t e s t i n a l e p i t h e l i a l cells t h r o u g h h i s t o n e acetylation. (Abstract# G3605) RD Fusunyan, JJ Quinn, M Fujimot0, RP MacDerm0tt and IR Sanderson. Boston and Burlington, MA G l u t a m a t e a n d a s p a r a g i n e p r o t e c t a g a i n s t the i n d u c t i o n of apoptosis i n g l u t a m i n e - d e p r i v e d i n t e s t i n a l e p i t h e l i a l cells. (Abstract# G3685) HT Papaconstantinou, SJ P0well, MR Hellmich, CM Townsend, Jr and TC Ko. Galveston, TX K e r a t i n o c y t e g r o w t h factor a n d n u t r i t i o n a l s t a t u s r e g u l a t e g l u t a t h i o n e redox state i n r a t j e j u n a l a n d ileal mucosa. (Abstract# G3632) CR Jonas, CF Estivariz, LH Gu, DP Jones and TR Ziegler. Atlanta, GA A novel zinc d e r i v a t i v e agent, polaprezinc, p r e v e n t e d the toxicity of bile acid a n d H202 on gastric epithelial cells i n a cell c u l t u r e model. (Abstract# G3747) S Watanabe, XE Wang, M Hirose, A Miyazaki and N Sate. Tokyo, Japan R e g u l a t i o n of i n t e s t i n a l d i a m i n e oxidase release. (Abstract# G3750) A W011in, D Sauder and P Tso. Saskat0on, Canada and Cincinnati, OH A n e w m e t h o d : gas c h r o m a t o g r a p h y mass spectroscopy to m e a s u r e b u t y r i c acid levels i n stool samples. (Abstract# G3573) C Compher, J Lawson, S McKinney, S Segall, J Park and J Rombeau. Philadelphia, PA The effects of c h r o n i c high-fat diet on g a s t r o i n t e s t i n a l t r a n s i t i n rat. (Abstract# G3724) A Shafat and RDE Rumsey. Sheffield, United Kingdom Effects of a p a n e l of l e c t i n s o n g a s t r o i n t e s t i n a l h o r m o n e r e l e a s e i n r a t s m a i n t a i n e d on total p a r e n t e r a l n u t r i t i o n . (Abstract# G3633) M Jordinson, RA Goodlad, A Brynes, Z Hussain, P Bliss, M Ghatei, SR Bloom, G Grant, A Pusztai and J Calam. London, United Kingdom and Aberdeen, Scotland

Colonic fate of m a l a b s o r b e d egg p r o t e i n . (Abstract# G3601) P Evenepoel, D Claus, B Geypens, P Rutgeerts and Y Ghoos. Leuven, Belgium Short c h a i n f a t t y acid m i x t u r e s m i m i c k i n g fiber digests i n d u c e CDK i n h i b i t o r s . (Abstract# G3745) J Wang and E Friedman. Syracuse, NY I n v/tro effects of lipid e m u l s i o n s u p o n i n f l a m m a t o r y cytokine p r o d u c t i o n b y p e r i p h e r a l blood m o n o n u c l e a r cells. (Abstract# G3713) JM Reimund, O Scheer, CD Muller, R Baumann and B Duclos. Strasbourg and Illkirch-Graffenstaden, France D i s a p p e a r a n c e of d i u r n a l r h y t h m of energy e x p e n d i t u r e i n genetically d i a b e t i c obese rats. (Abstract# G3622) M Ichikawa, K Miyasaka, M Ohta, Y Fujita and A Funakoshi. Tokyo and Fukuoka, Japan C o m p a r i s o n of t h e effects of olestra, b r a n a n d sorbitol o n stool viscosity i n a m b u l a t o r y mini-pigs. (Abstract# G3677) DE Neeley, KR Tyler, LJ Peters, JW McR0rie and B Greenwood-Van Meerveld. Oklahoma City, OK and Cincinnati, OH GROWTH, DEVELOPMENT, N U T R I T I O N - NUTRITION: CLINICAL AND A P P L I E D SCIENCE Which factors are associated to h y p e r m a n g a n e s e m i a i n patients with long term parenteral nutrition? (Abstract# G3714) JM Reimund, R Baumann and B Duclos. Strasbourg, France C o n t i n u o u s a n a l y s i s of the i n t e s t i n a l a b s o r p t i o n of elements i n m a n . (Abstract# G3711) DM Reffitt, JJ Powell and RPH Thompson. London, United Kingdom

P r o l i f e r a t i v e effects of a p a n e l of lectins i n r a t s m a i n t a i n e d o n t o t a l p a r e n t a l n u t r i t i o n . (Abstract# G3634) M Jordinson, RA Goodlad, G Grant, A Pusztai, M Pignatelli and J Calam. London, United Kingdom and Aberdeen, Scotland

Ferric t r i - m a l t o l gives effective i r o n delivery w i t h low side effect i n p a t i e n t s i n t o l e r a n t of ferrous p r e p a r a t i o n s . (Abstract# G3712) DM Poeffitt, RSJ Harvey, JJ Powell and RPH Thompson. London, United Kingdom

DDW Poster of Distinction:

Double b r e a t h c a r b o n stable isotope m e t h o d to m e a s u r e p a n c r e a t i c f u n c t i o n i n children. (Abstract# G3666) DI Mehta, EJ Reed, L Wang, S Shaffer and R Proujansky. Wilmington, DE

Acute colitis i n h i b i t s c e n t r a l n e u r o p e p t i d e Y-induced i n c r e a s e i n food i n t a k e a n d b o d y weight w i t h o u t affecting t h e h y p o t h a l a m i c NPY mRNA e x p r e s s i o n i n rats. (Abstract# G3669) M Million, A Kresse and Y TachS. Los Angeles, CA Effect of e l e m e n t a l diets +/- a d d i t i o n a l g l u t a m i n e o n small i n t e s t i n a l m o r p h o l o g y a n d r e s i s t a n c e to i n d o m e t h a c i n - i n d u c e d i n j u r y . (Abstract# G3698) T Podas, M Khatri; CE MacDonald, W Johnson, RA Goodlad and RJ Playford. Leicester, Liverpool and London, United Kingdom

H u m a n rectal a b s o r p t i o n of short- a n d m e d i u m - c h a i n C2-C10 fatty acids. (Abstract# G3635) J Jcrgensen, K Holtug, PB Jeppesen, K Haderslev and PB Mortensen. Copenhagen, Denmark Effect of a gluten-free diet o n m e t a b o l i c features i n a d u l t celiac p a t i e n t s . (Abstract# G3564) E Caprist0, G Addol0rato, G Mingrone, AV Grec0, GR Corazza and G Gasbarrini. Rome and L'Aquila, Italy

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DDW Poster of Distinction:

DDW Poster of Distinction:

MCT a c t i v a t e d i s t a l b u t n o t p r o x i m a l gut h o r m o n e s . (Abstract# G3743) MK Vu, M Verkijk, ESM Muller, I Biemond, CBHW Lamers and AAM Masclee. Leiden, The Netherlands

Effect of osmolality o n h u m a n small bowel m o t o r r e s p o n s e to d u o d e n a l e n t e r a l n u t r i t i o n . (Abstract# G3718) T Schmidt, P Rummel, H Kaess and A Pfeiffer. Munich, Germany

Sucrose p o l y e s t e r fails to i n d u c e g a l l b l a d d e r c o n t r a c t i o n a n d r e l e a s e of p l a s m a c h o l e c y s t o k i n i n i n h u m a n s . (Abstract# G3660) MIM Maas, WPM Hopman, MB Katan and JBMJ Jansen. Nijmegen, The Netherlands Gastrointestinal barrier in patients with chronic r e c u r r e n t u r t i c a r i a : effect of a l o w - p s e u d o a l l e r g e n diet. (Abstract# G3560) S Bfihner, I Ehlers, F Kfihl, T Zuberbier and H L0chs. Berlin, Germany GLP-1 r e l e a s e after l o w e r large bowel r e s e c t i o n or i n t r a r e c t a l glucose a d m i n i s t r a t i o n i n m a n . (Abstract# G3704) H Printz, S Reiter, N Samadi, A Wagner, R Arnold and B G6ke. Marburg, Germany I n f l u e n c e of w e a n i n g o n colonic b i f i d o b a c t e r i a a n d e n t e r o b a c t e r i a i n breast-fed i n f a n t s - a l o n g i t u d i n a l study. (Abstract# G3615) W Hachelaf, P Pochart, H BeUab~s, G Boudraa, JF Desjeux and M Touhami. Paris, France Beneficial effect of a bile acid r e s i n b i n d e r o n e n t e r a l f e e d i n g i n d u c e d d i a r r h e a . (Abstract# G3582) M DeMeo, S Kolli, A Keshavarzian and S Mobarhan. Maywood, IL V i t a m i n C, s m o k i n g a n d colorectal a d e n o m a s : is t h e r e a n i n t e r a c t i o n ? A case-control study. (Abstract# G3665) S M~ance, MC Boutron-Ruault, P Senesse and J Faivre. Paris and Dijon, France Gastric e m p t y i n g of a l i q u i d meal i n i n t e n s i v e care u n i t p a t i e n t s . (Abstract# G3549) J Barnett, D Dumitrascu, G Neeser, S Doesel and M Wienbeck. Augsburg, Germany and Cluj, Romania Efficacy, safety a n d t o l e r a n c e of g e r m i n a t e d b a r l e y foodsttLff f e e d i n g i n h u m a n s , (Abstract# G3671) K Mitsuyama, O Kanauchi, T Iwanaga, T Saiki, T Nakamura, K Agata, A Toy0naga and K Tanikawa. Kurume, Gunma and Sapporo, Japan P a t h o g e n e s i s of m a l n u t r i t i o n i n liver cirrhosis: role of pro- a n d a n t i i n f l a m m a t o r y cytokines. (Abstract# G3695) M Plauth, C Gerstner, T Schfitz, A-E R0ske, V v Baehr, HD Volk and H Lochs. Berlin, Germany 13C-mixed t r i g l y c e r i d e CO 2 e x h a l a t i o n test u s i n g a n isotope-selective n o n - d i s p e r s i v e i n f r a r e d spectrometer: n o r m a l values, i n f l u e n c e of age a n d g e n d e r a n d i n t r a i n d i v i d u a l r e p r o d u c i b i l i t y . (Abstract# G3692) B Pfaffenbach, C B6deker, C Szymanski, K Baumgarten and RJ Adamek. Bochum, Germany 13C-methacetin b r e a t h test as a q u a n t i t a t i v e f u n c t i o n test i n p a t i e n t s w i t h liver cirrhosis b y u s i n g a n isotopeselective n o n - d i s p e r s i v e i n f r a r e d spectrometer. (Abstract# L0509) B Pfaffenbach, O Goetze, C Szymanski, K Baumgarten and RJ Adamek. Bochum, Germany C o r r e l a t i o n b e t w e e n t h e o c c u r r e n c e of t h r o m b o s i s a n d s e r u m a u t o a n t i b o d y levels i n l u m i n a l gut f a i l u r e p a t i e n t s w i t h c e n t r a l lV access. (Abstract# G3623) A Idris, K Nash, Smalley, G Voeller, S Dietcher, M Dugdale and TL Abell. Memphis, TN

T r e a t m e n t of severe alcoholic h e p a t i t i s w i t h steroids or total e n t e r a l n u t r i t i o n . I n t e r i m r e s u l t s of a prospective, r a n d o m i z e d , m u l t i c e n t r i c trial. (Abstract# G3562) E Cabr~. Badalona, Barcelona, Tarragona, Oviedo, Cordoba and Gir0na, Spain Endoscopic p e r c u t a n e o u s j e j u n o s t o m y - d i r e c t p u n c t u r e of the small i n t e s t i n e for n u t r i t i o n . (Abstract# G3612) KE Grund, D Stueker and U Schrimpf. Tubingen, Germany Feasibility a n d safeness of u l t r a s o u n d - g u i d e d p e r c u t a n e o u s j e j u n o s t o m y . (Abstract# G3742) H van Overhagen, HW Tilanus, BC Halfhide, J Dees and JS Lam~ris. Rotterdam, The Netherlands I m m e d i a t e v e r s u s next day P E G feeding: a r a n d o m i z e d prospective s t u d y i n I C U / i n t e r m e d i a t e care p a t i e n t s . (Abstract# G3719) A Schulte-Bockholt, M Sabin, U Rosenstock, S Clemens, A Hofmann, U Brandt and M Keymling. Meiningen, Germany Audit of n u t r i t i o n a l m a n a g e m e n t of c h r o n i c i n t e s t i n a l p s e u d o - o b s t r u c t i o n with t u b e feedings. (Abstract# G3720) JS Scolapio, CR Fleming and M Camilleri. Jacksonville, FL and Rochester, MN Nutritional support in children undergoing bone m a r r o w t r a n s p l a n t a t i o n : e n t e r a l or p a r e n t e r a l ? (Abstract# G3619) E Hopman, E Pefia, W Broekh0f, Sle Cessie, A de Hullu, M van Weel, J Wit, J V0ssen and M Mearin. Leiden, The Netherlands A c o m p a r i s o n of the effect of e l e m e n t a l a n d i m m u n e e n h a n c i n g polymeric j e j u n a l f e e d i n g o n e x o c r i n e p a n c r e a t i c f u n c t i o n . (Abstract# G3589) DR Duerksen, S Bector, D Parry, C Yaffe, A Vajener and J Lipschitz. Winnipeg, Canada Benefit of t h e t r e a t m e n t b y ursodeoxycholic acid a n d t a u r i n e for c h r o n i c cholestasis associated w i t h long t e r m p a r e n t e r a l n u t r i t i o n . (Abstract# G3567) M Cavicchi, P Beau and B Messing. Paris and Poitiers, France IMMUNOLOGY, MICROBIOLOGY, AND INFLAMMATORY DISORDERS - - MUCOSAL IMMUNOLOGY

DDW Poster of Distinction: Mucosal i m m u n e responses to fed soluble p r o t e i n a n t i g e n i n T cell r e c e p t o r t r a n s g e n i c mice. (Abstract# G4229) T Marth, B Kelsall, W Strober and M Zeitz. Homburg/Saar, Germany and Bethesda, MD Fas l i g a n d - m e d i a t e d k i l l i n g b y i n t e s t i n a l i n t r a e p i t h e l i a l lymphocytes: p a r t i c i p a t i o n i n graft-versus-host disease. (Abstract# G4186) T Lin, J Madsen, M Reaves and D Green. San Diego, CA and New Haven, CT

A p r i l 1998

P R O G R A M O F T H E A N N U A L M E E T I N G P85

A G A P O S T E R S E S S I O N m M O N D A Y , M A Y 18, 1998 E n h a n c e d i n d u c t i o n of i m m u n o l o g i c tolerance after b r e a k i n g the colonic m u c o s a l b a r r i e r . (Abstract# G4431) F Seibold, C Weaver, M Scheurlen and CO Elson. Birmingham, AL and Wiirzburg, Germany I n t r a v i t a l o b s e r v a t i o n of h o m i n g of l a m i n a p r o p r i a l l y m p h o c y t e s i n m u r i n e i n t e s t i n a l mucosa. (Abstract# G4142) S Koseki, S Miura, H Fujimori, R Hokari, Y Tsuzuki, H Higuchi, H Serizawa, S Hachimura, S Kaminogawa and H Ishii. Tokyo, Japan The p r o d u c t i o n of i n t e r f e r o n . g a m m a i n h u m a n l a m i n a p r o p r i a T cells is r e g u l a t e d b y i n t e r l e u k i n (IL)-12, IL-7 a n d IL-15. (Abstract# G4267) G Monteleone, T Parrello, R Marasco, L Sebkova, S Tammaro, I Monteleone, F Luzza, P Doldo and F Pallone. Catanzaro, Italy H u m a n l a m i n a p r o p r i a T l y m p h o c y t e s do not p r o l i f e r a t e i n r e s p o n s e to i n t e r l e u k i n (IL)-12: r e l a t i o n to defective IL-12 r e c e p t o r ~1 s u b u n i t expression. (Abstract# G4266) G Monteleone, T Parrello, L Sebkova, S Tammaro, I Monteleone, F Luzza, P Doldo and F Pallone. Catanzaro, Italy S u b s t a n c e P r e g u l a t e s s o m a t o s t a t i n expression i n i n f l a m m a t i o n . (Abstract# G3832) A Blum, D Elliott, A Metwali, J Li, K Qadir and J Weinstock. Iowa City, IA A u n i q u e mode of CD28 a u g m e n t a t i o n of IL-2 e x p r e s s i o n i n l a m i n a p r o p r i a T cells: mRNA s t a b i l i z a t i o n w i t h o u t t r a n s a c t i v a t i o n of the CD28 r e s p o n s e element. (Abstract# G4172) DH Lee, R Gonsky, RL Deem and SR Targan. Los Angeles, CA Interferon-~ is a s u p p r e s s i v e c y t o k i n e i n d u c e d b y oral a n t i g e n . (Abstract# G4174) H Lee, LJ Tan, SD Hurst, SD Miller and TA Barrett. Chicago, IL Sialic acid r e s i d u e s o n the e p i t h e l i a l cell m e m b r a n e glycoprotein, gp180, p l a y a role i n the i n t e r a c t i o n s b e t w e e n i n t e s t i n a l e p i t h e l i a l cells a n d T cells. (Abstract# G4585) XY Yio, XT Wang, LS Toy, N Campbell and L Mayer. New York, NY Where do M cells go? I d e n t i f i c a t i o n of t h e i r d e s q u a m a t i o n sites i n r a b b i t Peyer's patches a n d a p p e n d i x b y i m m u n o h i s t o c h e m i c a l l a b e l i n g of M cell cytoplasmic v i m e n t i n . (Abstract# G4326) RL Owen and AJ Piazza. San Francisco, CA M a n n o s e b i n d i n g l e c t i n g e n o t y p e as a risk factor for i n t e s t i n a l protozoal i n f e c t i o n i n AIDS. (Abstract# G4126) P Kelly, D Jack, A Naeem, M Turner and MJG Farthing. London, United Kingdom I m m u n o l o g i c a l evidence for a n t i i n f l a m m a t o r y p r o p e r t i e s of bowel rest. (Abstract# G4418) A Schmit, A Van Gossum, M Carol and F Mascart-Lemone. Brussels, Belgium Localization a n d activity of n i t r i c oxide synthases i n t h e g a s t r o i n t e s t i n a l t r a c t of Trffp~mosoma cruzJinfected mice. (Abstract# G4309) L Ny, K Persson, LM Weiss, VL Braunstein, M Wittner and HB Tanowitz. Lund, Sweden and Bronx, NY

In Mtu d e m o n s t r a t i o n of a l t e r e d T l y m p h o c y t e m i g r a t i o n i n i n t e s t i n e by a c t i v a t i o n w i t h anti-CD3. (Abstract# G4017) H Fujimori, S Miura, S Koseki, R Hokari, Y Tsuzuki, H Higuchi, H Serizawa, S Hachimura, S Kaminogawa and H Ishii. Tokyo, Japan P r o l o n g e d e n g a g e m e n t of CD2 w i t h its n a t u r a l l i g a n d (CD58) p o t e n t i a t e s s u b s e q u e n t IFN-y p r o d u c t i o n : a m e c h a n i s m for i n d u c t i o n of a h y p e r r e s p o n s i v e CD2 p a t h w a y i n l a m i n a p r o p r i a T cells? (Abstract# G4543) A Vidrich, A Yuhasz and SR Targan. Los Angeles, CA B cell deficiency u p r e g u l a t e s t h e m u r i n e i n t r a e p i t h e l i a l lymphocyte c o m p a r t m e n t a n d d i s r u p t s genesis of Peyer's patches. (Abstract# G4524) N Van Houten, J Pappo, WB Gourley and M Epstein. Galveston, TX; Cambridge, MA and Vienna, Austria Molecular a n a l y s i s of the j u n c t i o n a l diversity of IgA h e a v y chains i n h u m a n i n t e s t i n e a n d p e r i p h e r a l blood: evidence for oligoclonal IgA B cell e x p a n s i o n s i n h e a l t h y subjects. (Abstract# G4086) W Holtmeier, A Hennemann and WF Caspary. Frankfurt, Germany The T cell r e c e p t o r ~ r e p e r t o i r e i n n o r m a l a n d i n f l a m e d h u m a n i n t e s t i n e . (Abstract# G4087) W Holtmeier, A Hennemann, E May, SR Carding, LD McVay, R Duchmann and WF Caspary. Frankfurt and Mainz, Germany; Philadelphia, PA Cytokine s e c r e t i o n b y p u r e p r e p a r a t i o n s of i n t e s t i n a l macrophages. (Abstract# G4381) G Rogler, M Hausmann, D Vogl, T Andus, W Falk, J Sch61merich and V Gross. Regensburg, Germany I m m u n o h i s t o c h e m i c a l a n d a n t i g e n u p t a k e studies i n r a b b i t p a l a t i n e tonsils a n d P e y e r ' s patches. (Abstract# G3868) W Brown, M Le, S-H Lee and E Boedeker. Denver, CO and Baltimore, MD Oral tolerance i n h u m a n s - e v i d e n c e for active s u p p r e s s i o n as a m e c h a n i s m for t o l e r a n c e p r o d u c t i o n to soluble p r o t e i n antigens. (Abstract# G3845) JR Boulton-Jones and A Ferguson. Edinburgh, Scotland T r i g g e r i n g of a c t i v a t e d CD2 m a k e s l a m i n a p r o p r i a lymphocytes r e f r a c t o r y to CD3frCR s t i m u l a t i o n . (Abstract# G3976) EC Ebert and AI Roberts. New Brunswick, NJ Loss of e n t e r a l n u t r i t i o n r e s u l t s i n a l t e r a t i o n s i n t h e i n t e s t i n a l i n t r a e p i t h e l i a l lymphocytes. (Abstract# G4135) I Kiristioglu, B Forbush, DH Teitelbaum, RL Mosley and KP Heidelberg. Ann Arbor, MI Soluble factors secreted b y IBD t i s s u e explants c a n i n d u c e B7-2 e x p r e s s i o n o n i n t e s t i n a l crypt e p i t h e l i a l cells: relevance w i t h u l c e r a t i v e colitis. (Abstract# G4329) A Panja, A Bogart and L Mayer. New York, NY Massive d e p l e t i o n of epithelial 75 T cells i n acute, b u t n o t chronic GVHD: a role for d o n o r FasL. (Abstract# G4369) M Reaves, T Lin, J Madsen and DR Green. San Diego, CA and New Haven, CT N e u r o n a l r e g u l a t i o n of i n t e r l e u k i n - 6 secretion b y s u b s t a n c e P i n the i n t e s t i n a l wall of Balb/C mice. (Abstract# G4467) RH Straub, M Kubitza, H Herfarth, W Falk and J Sch6lmerich. Regensburg, Germany

P86PROGRAMOFTHEANNUALMEETING II

AGA

POSTER

GASTROENTEROLOGYVol.1147No.4 SESSION

L o c a l i z a t i o n of t r a n s f o r m i n g g r o w t h factor-~ r e c e p t o r I, II a n d III i n the p o s t n a t a l r a t small i n t e s t i n e . (Abstract# G4595) MF Zhang, H Z01a, LC Read and IA Penttila. Adelaide, Australia I n t r a g a s t r i c p l a s m i d DNA i m m u n i z a t i o n i n d u c e s CD4+ s p l e n i c T cells p r o d u c i n g i n t e r f e r o n ~ / a n d i n t e r l e u k i n 10. (Abstract# G4396) A Saito, A Irisawa, Y Sato, K Obara, T Nishimaki and R Kasukawa. Fukushima, Japan H y p e r r e a c t i v i t y of B cells i n t h e a p p e n d i x l y m p h o i d follicle of T C R - a - m u t a n t mice. (Abstract# G4262) E Mizoguchi, A Miz0guchi, RN Smith, K Higaki and AK Bhan. Boston, MA

-- MONDAY,

MAY

18, 1998

DDW Poster of Distinction: Anti-CD3-induced T cell e n t e r o p a t h y is n o t d e p e n d e n t o n TNF-a m e d i a t e d pathways. (Abstract# G4250) M Merger, DA Clark, D Steele-Norwood, R Borojevic, RH Riddell and K Croitoru. Hamilton, Canada

DDW Poster of Distinction: Regional differences a n d m a g n i t u d e of e n d o t h e l i a l cell a d h e s i o n molecule e x p r e s s i o n i n SCID mice r e c o n s t i t u t e d with CD45RBmgh T lymphocytes. (Abstract# G3914) EM Conner, Z Morise, MJ Eppihimer, DN Granger and MB Grisham. Shreveport, LA

DDW Poster of Distinction:

Antigen.specific i n t e s t i n a l i n t e r l e u k i n - 1 0 expression is i n d e p e n d e n t of dose or r o u t e of a n t i g e n a d m i n i s t r a t i o n . (Abstract# G4300) RD Newberry and RG Lorenz. St Louis, MO

Loss of mucosal C D l a ÷ d e n d r i t i c ( a n t i g e n p r e s e n t i n g ) cells i n i n f l a m m a t o r y bowel disease. (Abstract# G4225) SD Mann, K Asaad, SC Knight, I Talbot and MA Kamm. Harrow, United Kingdom

Small i n t e s t i n a l c r y p t h y p e r p l a s i a a n d T cell a c t i v a t i o n i n A f r i c a n t r o p i c a l e n t e r o p a t h y . (Abstract# G4536) AM Veitch, P Kelly, N Luo, I Segal, SK Spies and MJG Farthing. London, United Kingdom; Lusaka, Zambia, Witwatersrand and Preteria, Africa

DDW Poster of Distinction:

L a c k of evidence for i n t e r f e r o n - g a m m a as a m e d i a t o r i n a graft-rejection m o d e l of e n t e r o p a t h y . (Abstract# G4535) AM Veitch, LM Higgins, TT MacDonald and MJG Farthing. London, United Kingdom

H u m a n colonic i n t r a e p i t h e l i a l l y m p h o c y t e s from p a t i e n t s w i t h colon c a n c e r d i s p l a y cytolytic activity a g a i n s t a d e n o c a r c i n o m a cells b u t n o t a g a i n s t none p i t h e l i a l d e r i v e d t u m o r s . (Abstract# G4308) NC Niissler, B Stange, AR MueUer, D Bergfeldt-Malinowski, R Neuhaus and P Neuhaus. Berlin, Germany Local e x p a n s i o n r a t h e r t h a n m i g r a t i o n d o m i n a t e s l a m i n a p r o p r i a CD4* T cell r e s p o n s e s to oral antigen. (Abstract# G3916) CJ Cooper, SM Sitterding, SD Hurst and TA Barrett. Chicago, IL I n t e r l e u k i n - 1 5 r e s p o n s i v e n e s s of i n t e r l e u k i n - 2 deficient mice. (Abstract# G4194) J Lodolce, D Boone, T Dassopoulos, S Chai, S Trettin and A Ma. Chicago, IL IMMUNOLOGY, MICROBIOLOGY, AND INFLAMMATORY DISORDERS - IBD: IMMUNOLOGY AND P A T H O G E N E S I S

DDW Poster of Distinction: P a t h o g e n i c role of IL-4, b u t n o t IFN-~ i n colitis of TCR-a k n o c k o u t mice. (Abstract# G4261) A Mizoguchi, E Mizoguchi, RN Smith, K Higaki and AK Bhan. Boston, MA

DDW Poster of Distinction: I n c r e a s e d e x p r e s s i o n of Fas l i g a n d o n CD45RO+ T lymphocytes i n colonic m u c o s a w i t h u l c e r a t i v e colitis. (Abstract# G4480) A Suzuki, K Sugimura, K Hasegawa, K Otsuka, K Suzuki, K Ishizuka, T Mochizuki, M Kobayashi, T Honma, R Narisawa and H Asakura. Niigata, Japan

Mucosal damage i n c h r o n i c DSS colitis i n mice is m e d i a t e d by IL-12 a n d p r e v e n t e d b y IL-10. (Abstract# G4311) F Obermeier, G Kojouharoff, J SchSlmerich, V Gross and W Falk. Regensburg, Germany

DDW Poster of Distinction: The p r e s e n c e a n d severity of n e u r a l i n f l a m m a t i o n p r e d i c t severe p o s t o p e r a t i v e r e c u r r e n c e of C r o h n ' s disease. (Abstract# G3950) G D'Haens, S Colpaert, M Peeters, F Baert, F Penninckx, P Rutgeerts and K Geboes. Leuven, Belgium

DDW Poster of Distinction: Evidence t h a t IL-1 r e c e p t o r isoforms c o n t r i b u t e to the IL-1 system i m b a l a n c e f o u n d i n IBD. (Abstract# G4565) J Woraratanadharm and TT Pizarro. Charlottesville, VA

DDW Poster of Distinction: I n t e r f e r o n r e g u l a t o r y factor-1 is i n c r e a s e d b u t p65/RelA is decreased i n l a m i n a p r o p r i a m o n o n u c l e a r cells i n Crohn's disease. (Abstract# G3903) M ClaveU, R Craver, A Delgado, MJS Miller, H Correa and E Mannick. New Orleans, LA

DDW Poster of Distinction: Effects of a n t i b i o t i c s o n the i n i t i a t i o n a n d p e r p e t u a t i o n of colitis i n the IL-10 KO mice. (Abstract# G3853) H Braat, LA Dieleman, RK Sellon, M Schultz and RB Sarter. Chapel Hill, NC and Seattle, WA E a r l y ileal lesions of Crohn's disease are associated w i t h the expression of IL-4 a n d IgE a n d n o t of i n f l a m m a t o r y cytokines. (Abstract# G3945) P Desreaumaux, K Geboes, L Gambiez, N Eeters, O Klein, A Cortot, M Capron and JF Colombel. Lille, France and Leuven, Belgium H u m a n i n t e s t i n a l m a s t cells p r o d u c e basic fibroblast growth factor i n fibrotic s t r i c t u r e s i n C r o h n ' s disease a n d i n n o r m a l i n t e s t i n e . (Abstract# G4251) S Mestermann, W Falk, V Gross, J Sch~lmerich and CM Gelbmann. Regensburg, Germany Local overexpression of IL-5 w i t h i n m u r i n e small bowel i n d u c e s local a n d m u c o s a l e o s i n o p h i l i a w i t h o u t a l t e r a t i o n s i n m u s c l e function. (Abstract# G4362) N Rad0jevic, BA Vallance, S San0vic and SM Collins. Hamilton, Canada

April 1998

PROGRAM OF THE ANNUAL MEETING P87

A G A P O S T E R S E S S I O N - - M O N D A Y , M A Y 18, 1 9 9 8 P e r s i s t e n t e n t e r i c muscle d y s f u n c t i o n a n d e x p u l s i o n of T. spiralis i n f e c t i o n s d e p e n d p a r t i a l l y u p o n IL-5 a n d eosinophils. (Abstract# G4516) BA Vallance, PA Blennerhassett, KI Matthaei, IG Young and SM Collins. Hamilton, Canada and Canberra, Australia

Antibodies a g a i n s t m o n o c y t e s i n i n f l a m m a t o r y bowel a n d a u t o i m m u n e l i v e r diseases. (Abstract# G4386) C Ro0zendaal, EJ Hummel, MA de Jong, JH Kleibeuker, AP Van den Berg, PC Limburg and CGM Kallenberg. Groningen, The Netherlands

P h e n o t y p i c c h a n g e s of i n t r a e p t i h e l i a l lymphocytes i n i n t e s t i n a l l e s i o n s of C r o h n ' s disease. (Abstract# G3969) S Dubucquoi, B Meresse, B Tourvieille-Philibert, D Koslowski, L Gambler, P Desreumaux, JF Col0mbel and JP Dessaint. Lille, France

H I ~ - D R 4 s u b t y p e s c a r r y i n g v a l i n e a t r e s i d u e 86 as a severity m a r k e r of u l c e r a t i v e colitis. (Abstract# G4198) G L6pez-Nava, M Fernfindez-Arquero, J Garcla-Paredes, F Vidal, P Vigil, JBA Crusius, AS Pefia, M Diaz-Rubio and EG de la Concha. Madrid and Barcelona, Spain; Amsterdam, The Netherlands

E x p r e s s i o n of i n t e r l e u k i n - 1 5 i n i n f l a m m a t o r y bowel disease. (Abstract# G4193) Z Liu, S Colpaert, C Van den Broeck, G D'Haens, J Ceuppens, K Geboes and P Rutgeerts. Leuven, Belgium E x p r e s s i o n of CD40 a n d CD40L i n i n f l a m m a t o r y bowel disease. (Abstract# G4192) Z Liu, S Colpaert, C Van den Br0eck, G D'Haens, J Ceuppens, K Geboes and P Rutgeerts. Leuven, Belgium A n t i - n e u t r o p h i l a n t i b o d i e s associated to u l c e r a t i v e colitis i n t e r a c t w i t h a n u c l e a r a n t i g e n d u r i n g t h e process of apoptosis. (Abstract# G4223) J Mallolas, M Esteve, E Riu8, E Cabr~ and MA Gassull. Badalona, Spain HLA-DR~71 r e s i d u e plays a critical role i n s u s c e p t i b i l i t y to u l c e r a t i v e colitis. (Abstract# G3996) M Fernandez-Arquero, G L6pez-Nava, J Garcia-Paredes, A Martinez, L C0nejer0, JBA Crusius, AS Pefia, M DiazRubi0 and EG de la Concha. Madrid and Barcelona, Spain; Amsterdam, The Netherlands Hellcobacter b e p a t i c u s does n o t p o t e n t i a t e colitis i n i n t e r l e u k i n - 1 0 - d e f i c i e n t mice. (Abstract# G3956) LA Dieleman, SL Tonkonogy, RK Sellon and RB Sartor. Chapel Hill and Raleigh, NC IL-12 r e c e p t o r 92 c h a i n u p r e g u l a t i o n i n m u c o s a l T cells i n e a r l y b u t n o t late C r o h n ' s disease: i m p l i c a t i o n s for v a r i a b l e IFN-y p r o d u c t i o n d u r i n g disease progression. (Abstract# G4157) S Kugathasan, J Itoh, D Kou, JT Boyle, AD Levine and C Fiocchi. Cleveland, OH H y p o r e s p o n s i v e to CD2-mediated a c t i v a t i o n b y u l c e r a t i v e colitis, b u t n o t Crohn's disease, m u c o s a l T cells. (Abstract# G4117) NE Joseph, C Fiocchi and AD Levine. Cleveland, OH Defective gp180 e x p r e s s i o n i n the buccal m u c o s a of p a t i e n t s w i t h u l c e r a t i v e colitis b u t n o t with C r o h n ' s disease. (Abstract# G4504) LS Toy, NA Campbell, AA Weiss, EJ Scherl and L Mayer. New York, NY I m p a i r m e n t of c e l l u l a r i m m u n e r e s p o n s i v e n e s s i n r e l a t i v e s of p a t i e n t s affected b y u l c e r a t i v e colitis. (Abstract# G3769) L Amati, L Caradonna, B Greco, G Leandro, D Caccavo and E Jirill0. Bari, Italy A c c u m u l a t i o n of m u l t i p l e T8 T cell clonotypes i n the i n t e s t i n a l m u c o s a from Crohn's d i s e a s e p a t i e n t s . (Abstract# G4120) H Kanazawa, Y Ishiguro and A Munakata. Hirosaki, Japan ICAM-1 a n d VCAM-1 expression i n e x p e r i m e n t a l colitis: r e l a t i o n w i t h n u c l e a r factor NF-r,B activation. (Abstract# G4406) M Sans, E Ardite, JI Elizalde, Y Arce, M Elena, JC Fern~ndez-Checa, J Pan~s and JM Pique. Barcelona, Spain

E n h a n c e m e n t of colonic m i c r o c i r c u l a t i o n stabilizes m u c o s a l p e r m e a b i l i t y i n e x p e r i m e n t a l colitis. (Abstract# G4149) AJ Kroesen, T Foitzik, H Hotz, M Kruschewski, M Fromm and HJ Buhr. Berlin, Germany I n t e s t i n a l m u c o s a l T cells u n d e r g o apoptosis i n h e a l t h b u t n o t i n C r o h n ' s disease (CD): a possible m e c h a n i s m for i m m u n e d y s r e g u l a t i o n i n CD. (Abstract# G3869) P Bu, A Keshavarzian, P Le and L Qiao. Maywood, IL CD4+ cells f o u n d i n t h e i n f l a m e d colon of SCID mice w i t h colitis are oligoclonal. (Abstract# G3778) R Aranda, FR Byrne, C Panwala, G Yakoub, BC Sydora, SR Targan and M Kronenberg. Los Angeles and San Diego, CA Molecular a n a l y s i s of HLA p o l y m o r p h i s m i n I t a l i a n p a t i e n t s affected b y Crohn's disease. (Abstract# G3891) F Castiglione, O Mercuro, G Pirozzi, V Lombari, G Del Vecchio Blanco, P Cannada Barteli, G Mazzacca, C Manzo and ML Lombardi. Naples, Italy I n n o r m a l a n d i n f l a m m a t o r y bowel disease mucosa, i n t e r l e u k i n - l ~ c o n v e r t i n g e n z y m e is expressed b y viable macrophages. (Abstract# G4240) ME McAlindon, A Galvin and YR Mahida. Nottingham, United Kingdom Analysis of anti-colonic a u t o a n t i b o d i e s i n p r i m a r y sclerosing cholangitis. (Abstract# G4313) JA Odin, L Casciola-Rosen and A Rosen. Baltimore, MD Anti-Gal a n t i b o d i e s i n p a t i e n t s w i t h i n f l a m m a t o r y bowel disease. (Abstract# G3928) M D'Alessandro, P Mariani, A Bachetoni, D L0manto, P Mazzocchi and V Speranza. Rome, Italy Role of g l u t a h i o n e i n the t r i n i t r o b e n z e s u l f o n i c acidi n d u c e d colitis i n t h e rat. (Abstract# G3779) E Ardite, M Sans, J Pan~s, JM Piqu~ and JC Fern~ndezCheca. Barcelona, Spain I n vivo fluorescence microscopy for a s s e s s m e n t of l e u k o c y t e - e n d o t h e l i a l - i n t e r a c t i o ni n t h e left colon i n d e x t r a n s u l p h a t e s o d i u m - i n d u c e d colitis. (Abstract# G3990) S Farkas, H Herfarth, M Steinbauer and M Anthuber. Regensburg, Germany Oral a d m i n i s t r a t i o n of i n t e s t i n a l flora sonicate r e d u c e s severity of DSS-induced acute colitis i n BALB/c mice. (Abstract# G4538) EF Verdd, P Michetti, MA FartS, P Bercik, E Saraga, AL Blum, H Tlaskalova-Hogenova and I Corth~sy-Theulaz. Prague, Czech Republic; Boston, MA and Lausanne, Switzerland Differential e x p r e s s i o n of n e u r o t r o p h i n s a n d t h e i r TRK t y r o s i n e k i n a s e r e c e p t o r s i n the i n f l a m e d colon of IL-2 k n o c k o u t mice. (Abstract# G4385) H R0hm, I Geerling, J Lakshmanan, G Adler and M Reinshagen. Ulm, Germany and Torrance, CA

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A G A P O S T E R S E S S I O N - - MONDAY, MAY 18, 1998 Antineutrophil cytoplasmic autoantibodies in amonozygotic t w i n s d i s c o r d a n t for i n f l a m m a t o r y bowel disease. (Abstract# G4472) J Subhani, RS Walmsley, AC Dunn, PC Chapman, A Br0wnlee, CM Lockwood, AJ Wakefield and RE Pounder. London and Cambridge, United Kingdom Absence of m e a s l e s v i r u s genome i n tissue a n d p e r i p h e r a l blood l y m p h o c y t e s from p a t i e n t s w i t h Crohn's disease. (Abstract# G3783) E Armitage, M Afzal, P Minor, S Ghosh and A Ferguson. Edinburgh, Scotland and Potters Bar, United Kingdom U p r e g u l a t i o n a n d coexpression of PACAP a n d PACAP type I r e c e p t o r s o n i n f i l t r a t i n g i m m u n e cells i n the TNB-colitis r a t model. (Abstract# G3807) A Belai, M Million, Y Tach~ and JR Pisegna. Los Angeles, CA L i m i t e d v a r i e t y of T cell clones c o m m o n l y e x p a n d e d both in involved mucosa and mesenteric lymph nodes of p a t i e n t s w i t h C r o h n ' s disease. (Abstract# G3761) K Adachi, T Matsumoto, N Shimizu, Y Sawa, S Nakamura, N Oshitani, A Kitano, T Arakawa, K Kobayashi, K Kuroki, Y Nishiguchi, K Maeda, M Sowa, T Fukushima, WR Brown and BL Kotzin. Osaka and Yokohama, Japan; Denver, CO

A n t i n e u t r o p h i l cytoplasmic a n t i b o d i e s i n A s i a n p a t i e n t s with i n f l a m m a t o r y bowel disease show n o c o r r e l a t i o n w i t h p r o t e i n a s e 3, l a c t o f e r r i n , myeloperoxidase, elastase, c a t h e p s i n G a n d lysozyme: a Singapore study. (Abstract# G4320) CJ Ooi, BL Lira, WK Cheong, AE Ling and HS Ng. Singapore, Singapore IMMUNOLOGY, MICROBIOLOGY, AND INFLAMMATORY DISORDERS - - IBD: CLINICAL FEATURES

DDW Poster of Distinction: Bile acid m a l a b s o r p t i o n i n collagenous colitis a n d lymphocytic colitis: a n o p e n label pilot t r i a l of c h o l e s t y r a m i n e to i n d u c e clinical r e m i s s i o n . (Abstract# G3997) F Fern~ndez-Bafiares, M Esteve, M Forn~, JC EspinSs, A Salas and JM Viver. Barcelona, Spain

DDW Poster of Distinction: Effects of s m o k i n g a n d oral c o n t r a c e p t i v e use o n t h e clinical course of C r o h n ' s disease. (Abstract# G3921) J Cosnes, F Carbonnel, F Carrat, L Beaugerie and JP Gendre. Paris, France

E x p r e s s i o n of i n t e g r i n a4~7 o n c i r c u l a t i n g a n d gut m u c o s a l l y m p h o c y t e s i n i n f l a m m a t o r y bowel disease. (Abstract# G3952) A Dhiman, A Ang, MJ Weld0n, JA Tooze, DJ Ringlet and JD Maxwell. London, United Kingdom and Cambridge, MA

Long t e r m e v o l u t i o n of oral l o c a l i z a t i o n of C r o h n ' s disease. (Abstract# G3920) A Cosnes, A Dupuy, J Revuz, JC Delchier, JF Contou, JP Gendre and J Cosnes. Cr~teil, France

E x p r e s s i o n of B7-1 a n d B7-2 c o s t i m u l a t o r y molecules i n c h r o n i c i n f l a m m a t o r y bowel disease. (Abstract# G3873) L Cam0glio, AA te Velde, NCJJ Ladiges and SHJ van Deventer. Amsterdam, The Netherlands

Symptomatic sacroileitis i n C r o h n ' s disease. (Abstract# G4116) HW Jones, P Gordon, J Hibbert, T Gibson and JD Sanderson. London, United Kingdom

E x p r e s s i o n of i n s u l i n - l i k e g r o w t h f a c t o r - b i n d i n g protein-5 a n d collagen i n e x p e r i m e n t a l colitis i n rats. (Abstract# G4593) JM Zeeh, NE Riley, M Reinshagen and H G0ebell. Ulm and Essen, Germany

DDW Poster of Distinction:

U p r e g u l a t i o n of E - c a d h e r i n a n d associated molecules (a-, ~-, a n d 7-catenins) i n i n f l a m e d bowel mucosa. (Abstract# G3943) P Demetter, E Cesmeli, M De Vos, G Bullock, N Van Damme, D Baeten, D Elewaut, H Mielants, G Verbruggen, F De Keyser, EM Veys and C Cuvelier. Ghent, Belgium

C o n c u r r e n t i n f l a m m a t o r y bowel disease a n d t h e leukemias. (Abstract# G4064) GC Harew00d, EV Loftus, Jr, WJ Sandborn and WJ Tremaine. Rochester, MN

The m o l e c u l a r specificity of t r o p o m y o s i n - r e a c t i v e a u t o a n t i b o d i e s i n u l c e r a t i v e colitis. (Abstract# G3934) A Dasgupta, X Geng, K Ramaswamy, K Kesari and KM Das. New Brunswick, NJ Activated p l a t e l e t s i n u l c e r a t i v e colitis e n h a n c e p r o d u c t i o n of r e a c t i v e oxygen metabolites by p o l y m o r p h o n u c l e a r cells. (Abstract# G4482) K Suzuki, K Sugimura, K Hasegawa, K Yoshida, T Honma, R Narisawa and H Asakura. Niigata, Japan A n t i - e n d o t h e l i a l cell a n t i b o d i e s i n Crohn's disease. (Abstract# G4008) FG Foschi, G Zoli, E Castelli, G Addol0rato, M Parazza, S Pagani, E Loggi, G Gasbarrini, GF Stefanini and M Bernardi. Bologna, Rome and Ravenna, Italy Analysis of p e r i p h e r a l blood T8 T cell levels i n i n f l a m m a t o r y bowel disease. (Abstract# G4132) G Him, T Wu, W Havran, R Boismenu and M Poleski. La Jolla, CA

P e r i a n a l Crohn's disease a n d p r e g n a n c y : role of the mode of delivery. (Abstract# G4101) A Ilnyckyj, JF Blanchard and CN Bernstein. Winnipeg, Canada

Segmental colitis l i m i t e d to the sigmoid colon: c a n we p r e d i c t the clinical course b a s e d u p o n endoscopic a n d histologic f i n d i n g s ? A long t e r m follow-up study. (Abstract# G4464) R Stein, J Hart and S Hanauer. Chicago, IL F r e q u e n c y a n d clinical e v o l u t i o n of i n d e t e r m i n a t e colitis: a r e t r o s p e c t i v e m u l t i c e n t e r s t u d y i n n o r t h e r n Italy. (Abstract# G4252) G Meucci, A Bortoli, F Albini, CM Girelli, F Radaelli, R Rivolta and M Tatarella. Rho, Como, Busto Arsizio, Monza and Milan, Italy Fecal ~ l - a n t i t r y p s i n as early i n d i c a t o r of clinical relapse i n Crohn's disease: r e s u l t s from a 4-year followup. (Abstract# G3819) L Biancone, M Silvestri and F PaUone. Rome and Catanzaro, Spain

April 1998

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A G A P O S T E R S E S S I O N - - M O N D A Y , M A Y 18, 1998 New i n s i g h t s i n t o t h e p a t h o g e n e s i s of a n e m i a of c h r o n i c diseases: i n d u c t i o n of f e r r i t i n synthesis a n d d e v e l o p m e n t of a n e m i a d u r i n g r e c o m b i n a n t h u m a n i n t e r l e u k i n - 1 0 t r e a t m e n t of c h r o n i c active Crohn's disease. (Abstract# G4499) H Tilg, A Kaser, S Schreiber, M Gregor, P Rutgeerts, S van Deventer, C Gasche, JC Koningsberger, L Abreu, B Duclos, RA van Hogezand, M Cohard, P Grint and G Weiss. Leuven, Belgium; Amsterdam, Utrecht and Leiden, the Netherlands; Vienna and Innsbruck, Austria; Berlin and Tuebingen, Germany; Madrid, Spain; Strasbourg, France and Kenilworth, NJ S u b c l i n i c a l signs i n o c u l a r a s y m p t o m a t i c i n f l a m m a t o r y bowel disease p a t i e n t s . (Abstract# G3767) C Alvisi, A Di Maria, M Perego, G Ruberto, R Frego, L Centenara and C Klersy. Pavia, Italy IL-I~ a n d g r a n u l o c y t e elastase i n whole gut lavage fluid p r e d i c t s r e l a p s e i n p a t i e n t s w i t h i n a c t i v e Crohn's disease. (Abstract# G3787) IDR Arnott, HE Drummond, S Ghosh and A Ferguson. Edinburgh, Scotland

I n c r e a s e of bone m i n e r a l d e n s i t y w i t h s o d i u m fluoride i n p a t i e n t s with C r o h n ' s disease. (Abstract# G4548) C yon Tirpitz, J Klaus, J Brfickel, A Rieber, BO B6hm, G Adler and M Reinshagen. Ulm, Germany Low b o n e m i n e r a l d e n s i t y i n C r o h n ' s disease occurs i n d e p e n d e n t of cortieosteroid use. (Abstract# G4444) MS Silverberg, S Mikolainis and AH Steinhart. Toronto, Canada P r e v a l e n c e of clinical a n d s u b c l i n i c a l spondyloarthropathy in patients with inflammatory bowel disease. (Abstract# G3947) M De Vos, K De Vlam, D Elewaut, H Mielants, E Cesmeli, F De Keyser, C Cuvelier and E Veys. Ghent, Belgium I n c r e a s e d s e r u m levels of b o n e s i a l o p r o t e i n i n p a t i e n t s w i t h i n f l a m m a t o r y bowel disease. Role of p r o i n f l a m m a t o r y cytokines. (Abstract# G4248) F Menge, M Karmatschek, WF Caspary and J Stein. Frankfurt, Germany

A b n o r m a l i n t e s t i n a l p e r m e a b i l i t y predicts relapse i n p a t i e n t s w i t h i n a c t i v e C r o h n ' s disease. (Abstract# G3785) IDR Arnott, S Ghosh and A Ferguson. Edinburgh, Scotland

Side-to-side stapled v e r s u s end-to-end s u t u r e d a n a s t o m o s i s following ileocolonic r e s e c t i o n for Crohn's disease: complications a n d early r e c u r r e n c e rates. (Abstract# G4578) T Yamamoto, IM Bain, RN Allan and MRB Keighley. Birmingham, United Kingdom

Drugs as r i s k factors for r e l a p s e of i n f l a m m a t o r y bowel disease: r e s u l t s of a case-control study. (Abstract# G3757) C Aalykke, JM Lauritsen, J Hallas, LS Laursen, J Kjeldsen and K Lauritsen. Odense, Denmark

Risk factors for a n a s t o m o t i c r e c u r r e n c e after ileocolonic r e s e c t i o n for Crohn's disease: the i m p o r t a n c e of smoking. (Abstract# G4577) T Yamamoto, IM Bain, RN Allan and MRB Keighley. Birmingham, United Kingdom

I n f l u e n c e of Helicobacterpylorl infection on the course of C r o h n ' s disease. (Abstract# G4359) A Pfisp6k, C Dejaco, T Waldh6r, G Oberhuber, H Vogelsang and C Gasche. Vienna, Austria

Ileoanal pull-through improves health-related quality of life i n p a t i e n t s w i t h a h i s t o r y of u l c e r a t i v e colitis. (Abstract# G4276) A Muir, B Phillips-Bute, M Eloubeidi, C Sears, RR Bollinger, M Koruda, L Hurd, D Bachwich, D Drossman and D Provenzale. Durham and Chapel Hill, NC; Philadelphia, PA

A r t h r o p a t h y i n ileal p o u c h p a t i e n t s is n o t r e l a t e d to the p r e s e n c e of pouchitis. (Abstract# G4496) PD Thomas, A Keat, A Forbes, PJ Ciclitira and RJ Nicholls. London, United Kingdom R e l a t i o n s b e t w e e n disease activity a n d tissue cytokine a n d d r u g levels i n p a t i e n t s w i t h u l c e r a t i v e colitis. (Abstract# G4094) F Hussain, R Ajjan, M Moustafa, R Bolton, M Grundman and S Riley. Sheffield, United Kingdom I d i o p a t h i c proctitis: a follow-up s t u d y o n predictive factors for diffusion. (Abstract# G4097) M Iacucci, MC Di Paolo, OA Paoluzi, F Ricci, F Maggio and P Paoluzi. Rome, Italy

Abscesses i n Crohn's disease - o u t c o m e of medical v e r s u s surgical t r e a t m e n t . (Abstract# G4025) JC Garcia, S Persky, PAL Bonis and M Topazian. New Haven, CT Prospective comparison between endosonography, magnetic resonance imaging and surgical exploration i n the a s s e s s m e n t of a n o r e c t a l fistulas a n d abscesses c o m p l i c a t i n g Crohn's disease. (Abstract# G3800) M Barthet, P Orsoni, M Panuel, P Mambrini, J Salducci, JC Grimaud and A Desjeux. Marseille, France

I m p a c t of depressive mood o n r e l a p s e of p a t i e n t s with i n f l a m m a t o r y bowel disease - a prospective one y e a r follow-up study. (Abstract# G4259) C Mittormaier, M Beier, W Tillinger, A Gangl and G Moser. Vienna, Austria

Laparoscopic r e s e c t i o n of i n f l a m m a t o r y bowel disease. (Abstract# G4591) T Young-Fadok, F Potenti, H Nelson, J Fleshman, S Wexner, M Anvari, S Stryker, A Tootla and A Fine. Ft Lauderdale, FL; Rochester, MN; St Louis, MO; Hamilton, Canada; Chicago, IL; Pontiac, MI and Pittsburgh, PA

P r e g n a n c y a n d i n f l a m m a t o r y bowel diseases: a p r o s p e c t i v e case-control study. (Abstract# G3843) A Bortoli, M Tatarella, A Prada, A CorberUini, P Politi, C Terraroli, G Mortara, R Rivolta, M Carnovali, F Redaelli, T Ranzi and the Gruppo Studio Malattie Infiammatorie Intestinali. Milan, Melegnano, Cremona, Brescia, Monza and Como, Italy

P a t i e n t preferences r e g a r d i n g p r o p h y l a x i s for the p r e v e n t i o n of p o s t o p e r a t i v e C r o h n ' s disease. (Abstract# G4129) ED Kennedy, BI O'Connor, M Varkul, A Detsky and RS McLeod. Toronto, Canada

Bone m i n e r a l d e n s i t y i n Crohn's disease p a t i e n t s r e c e i v i n g l o n g t e r m b u d e s o n i d e . (Abstract# G3902) M Cino and GR Greenberg. Toronto, Canada

Small bowel b a c t e r i a l o v e r g r o w t h i n p a t i e n t s after ileal p o u c h - a n a l anastomosis; a p r o s p e c t i v e analysis u s i n g b r e a t h h y d r o g e n testing. (Abstract# G4445) EJ Simchuk and RC Thirlby. Seattle, WA

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P90 PROGRAMOF THE ANNUALMEETING ]]

AGAPOSTER

SESSION--MONDAY,

H O R M O N E S , T R A N S M I T T E R S , G R O W T H FACTORS A N D T H E I R R E C E P T O R S - - P H Y S I O L O G Y AND C E L L B I O L O G Y II

D D W Poster of Distinction:

MAY

18, 1998

A d u l t h u m a n colonic s u b e p i t h e l i a l m y o f i b r o b l a s t s regulate epithelial secretory response and barrier f u n c t i o n v i a d i s t i n c t p a t h w a y s . (Abstract# G4616) J Beltinger, S Makh, WA Stack, CJ Hawkey and YR Mahida. Nottingham, United Kingdom

Pituitary adenylate cyclase activating peptide: a

D D W Poster of Distinction:

neuropeptide

E x p r e s s i o n in r a t G-cells of v e s i c u l a r m o n o a m i n e t r a n s p o r t e r t y p e 1 a n d i t s r o l e in m o d u l a t i n g c o n v e r s i o n of G34 to G17. (Abstract# G4612) GW Bate, I Hussein, P Djali, R Dimaline, A Varro and GJ Dockray. Liverpool, United Kingdom

that stimulates gastric acid secretion.

(Abstract# G4888) N Zeng, T Kang, RM Lyu, GA Ohning, YF Wang, JH Walsh, G Sachs and JR Pisegna. Los Angeles, CA PACAP s t i m u l a t e s g a s t r i c a c i d s e c r e t i o n d u r i n g s o m a t o s t a t i n i m m u n o n e u t r a l i z a t i o n i n r a t s . (Abstract# G4788) GV Ohning, A Curl, RM Lyu, N Zeng, HC Wong, G Sachs, JH Walsh and JR Pisegna. Los Angeles, CA

D D W Poster of Distinction: E n d o g e n o u s GLP-l(7-36)amide c o n t r o l s e n d o c r i n e pancreatic secretion and antroduodenal motility in h u m a n . (Abstract# G4819) J Schirra, R Roggel, P Leicht, U Wank, R Arnold, B G6ke and M Katschinski. Marburg, Germany Exendin(9-39)amide, b u t n o t exendin(3-39)amide, is a n a n t a g o n i s t of GLP-1(7-36)amide i n h u m a n . (Abstract# G4820) J Schirra, M Junck, G Kraft, H Schmidt, U Wank, P Leicht, B G6ke and M Katschinski. Marburg, Germany Effects of GLP-1 on p r o x i m a l g a s t r i c m o t o r a n d s e n s o r y f u n c t i o n i n h u m a n . (Abstract# G4864) U Wank, J Schirra, R Arnold, B G6ke and M Katschinski. Marburg, Germany [SerS]GLP-l(7-36)amide is a GLP-1 a n a l o g u e w i t h i m p r o v e d p l a s m a s t a b i l i t y . (Abstract# G4807) U Ritzel, U Le0nhardt, K Eckart, A Rfihmann, J Spiess and G Ramad0ri. Goettingen, Germany Effect of g l u c a g o n - l i k e ppeptide-1(7-36)amide on j e j u n a l m o t o r a n d e n d o c r i n e r e s p o n s e s to s o l i d meals. (Abstract# G4718) M Katschinski, A Minuth, U Wank, R Arnold, B G6ke and J Schirra. Marburg, Germany R e g u l a t i o n of c h o l e c y s t o k i u l n s e c r e t i o n i n STC-1 cells t h r o u g h p H - s e n s i t i v e p o t a s s i u m c h a n n e l s . (Abstract# G4862) Y Wang, V Prpic, JG Fitz and RA Liddle. Durham, NC and Denver, CO The c e l l u l a r m e c h a n i s m of s o d i u m o l e a t e - s t i m u l a t e d C C K r e l e a s e f r o m STC-1 cells. (Abstract# G4643) CHL Chang, WY Chey and TM Chang. Rochester, NY G a l a n i n i n h i b i t s s o d i u m o l e a t e - s t i m u l a t e d CCK r e l e a s e f r o m STC-1 cells. (Abstract# G4642) CHL Chang, WY Chey, DH Coy and T-M Chang. Rochester, NY and New Orleans, LA N e u r a l p a t h w a y s i n v o l v e d i n t h e colonic s e c r e t o r y r e s p o n s e to NK 3 a c t i v a t i o n . (Abstract# G4691) JM Goldhill and I Angel. Rueil-Malmaison, France A r g i n i n e i n d u c e s i n c r e t i n s e c r e t i o n i n r a t s . (Abstract# G4703) C Herrmann-Rinke, U Beyer, R Arnold and B G6ke. Marburg, Germany PYY r e l e a s e b y f a t i n t h e p r o x i m a l h u t n o t d i s t a l 1/2 of g u t d e p e n d s on a t r o p i n e - b l o c k a b l e c h o l i n e r g i c p a t h w a y . (Abstract# G4744) HC Lin, IL Taylor, LJ Wang and XT Zhao. Los Angeles, CA and Charleston, SC

Cyclic n u c l e o t i d e - g a t e d c a t i o n c h a n n e l s i n r a t intestine: distribution and functional regulation. (Abstract# G4860) X-T Wang, W Qiu, B Lee and S Guggino. Baltimore, MD T r y p s i n a c t i v a t e s i o n c h a n n e l s of d o g p a n c r e a t i c d u c t cells v i a p r o t e i n a s e - a c t i v a t e d receptors-2. (Abstract# G4782) TD Nguyen, MW Moody and CN Okol0. Seattle, WA and San Francisco, CA Secretin induces transepithelial ion transports and a l k a l y z a t i o n of m u c o s a l s o l u t i o n i n m o n o l a y e r c u l t u r e of i n t e s t i n a l (CaCo-2) cells. (Abstract# G4675) M Fukuda, A Ohara, T Bamba and Y Saeki. Ohtsu, Japan 5-hydroxytryptamine receptors mediate the release and a c t i o n of s e c r e t i n o n p a n c r e a t i c s e c r e t i o n i n d u c e d b y d u o d e n a l a c i d i f i c a t i o n in r a t s . (Abstract# G4740) P Li, TM Chang and WY Chey. Rochester, NY

D D W Poster of Distinction: E x p r e s s i o n of VAMP-2/synaptobrevin, SNAP-25 a n d syntaxin-1 in e n t e r o e n d o c r i n e cell lines: i n v o l v e m e n t of t e t a n u s toxin-sensitive protein(s) i n c h o l e c y s t o k i n i n r e l e a s e from STC-1 cells. (Abstract# G4780) E N6moz-Gaillard, A Bosshard, S Catsicas, C Bernard, JC Cuber, M Takahashi, JA Chayvialle and J Abello. Lyon, France; Lausanne, Switzerland and Tokyo, Japan I n t r a c e l l u l a r m e c h a n i s m of h y d r o g e n p e r o x i d e m e d i a t e d n e u t r o p h i l a d h e r e n c e to c u l t u r e d e n d o t h e l i a l cell m o n o l a y e r s w i t h r e s p e c t to a d h e s i o n molecule. (Abstract# G4790) N Okayama, L Coe and JS Alexander. Shreveport, LA I s o l a t i o n a n d f u n c t i o n a l c h a r a c t e r i z a t i o n of zonulin, a p h y s i o l o g i c m o d u l a t o r of t i g h t j u n c t i o n s . (Abstract# G4671) A Fasano, W Wang and W Nie. Baltimore, MD C e l l u l a r l o c a l i z a t i o n of CCK-B/gastrin r e c e p t o r i n t h e h u m a n s t o m a c h b y i m m u n o h i s t o c h e m i s t r y a n d b y in situ r e v e r s e t r a n s c r i p t a s e - p o l y m e r a s e c h a i n r e a c t i o n . (Abstract# G4734) H Kulaksiz, R Arnold, WG Forssmann, B G6ke and R Eissele. Hann0ver, Germany 1,25(OH) 2 v i t a m i n D s a n d TPA s t i m u l a t e p h o s p h a t i d y l c h o l i n e - p h o s p h o l i p a s e D i n CaCo-2 cells: r o l e of PKC, Rho, a n d c-Src in PLD s t i m u l a t i o n . (Abstract# G4724) S Khare, RK Wall, M Bissonnette, B Scaglione-Sewell, MD Sitrin and TA Brasitus. Chicago, IL P r o g a s t r i n p r o c e s s i n g in p r i m a r y a n t r a l G cells is m e d i a t e d b y p r o h o r m o n e c o n v e r t a s e 2. (Abstract# G4840) VM Stepan, J Del Valle and CJ Dickinson. Ann Arbor, MI

April 1998

PROGRAMOF THEANNUALMEETINGP91

AGA P O S T E R S E S S I O N m MONDAY, MAY 18, 1998 Secretin-Gly is a m a j o r p r o d u c t of p r e p r o s e c r e t i n p r o c e s s i n g i n r a t small i n t e s t i n e : i d e n t i f i c a t i o n a n d q u a n t i t a t i o n b y HPLC a n d r a d i o i m m u n o a s s a y . (Abstract# G4892) Y Zong, JR Reeve, Jr, JH Walsh, P Gong, FJ Ho and TE Solomon. Los Angeles, CA HORMONES, TRANSMITTERS, GROWTH FACTORS AND T H E I R R E C E P T O R S - - BRAIN-GUT AXIS New p o t e n t s o m a t o s t a t i n r e c e p t o r 2 a n t a g o n i s t i n h i b i t s S R I F a n d S R I F - m e d i a t e d effects o n p e n t a g a s t r i n s t i m u l a t e d gastric acid s e c r e t i o n i n conscious rats. (Abstract# G4808) WJ R0ss0wski, B-L Cheng and DH Coy. New Orleans, LA

DDW Poster of Distinction: A c t i v a t i o n of c e n t r a l s o m a t o s t a t i n receptor 5 s t i m u l a t e s g a s t r i c e m p t y i n g i n rats. (Abstract# G4756) V Martfnez, DH Coy and Y TachS. Los Angeles, CA and New Orleans, LA I n t r a c i s t e r n a l i n j e c t i o n of low-doses of s o m a t o s t a t i n analogue, ODTS-SS, i n c r e a s e s the gastric r e s i s t a n c e to e t h a n o l t h r o u g h vagal, n o n - m u s c a r i n i c p a t h w a y i n rats. (Abstract# G4722) K Kawakubo and Y TachS. Los Angeles, CA C e n t r a l s o m a t o s t a t i n a b o l i s h e d a n i n h i b i t o r y effect on p a n c r e a t i c b a s a l s e c r e t i o n p r o d u c e d by c e n t r a l l y a d m i n i s t e r e d CGRP i n conscious rats. (Abstract# G4768) K Miyasaka, S Kanai, M Masuda and A Funakoshi. Tokyo and Fukuoka, Japan

Cholecystokinin microinfused into the paraventricular n u c l e u s of the h y p o t h a l a m u s i n h i b i t s gastric e m p t y i n g a n d s t i m u l a t e s colonic m o t o r a c t i v i t y i n the conscious rat. (Abstract# G4843) J Tebbe, H M6nnikes, K Pluntke, C Bauer and R Arnold. Marburg, Germany T h y r o t r o p i n - r e l e a s i n g h o r m o n e i n t h e left dorsal vagal complex i n c r e a s e s the h e p a t i c blood flow i n rats. (Abstract# G4879) M Yoneda, K Tamori, Y Nakade, S Takam0to, S Yokohama, K Aso, Y Sato, M Aoshima, K Nakamura and I Makino. Asahikawa, Japan SR48692 p r e t r e a t m e n t blocks t h e p r o t e c t i v e a n d antiacid secretory effects of icy n e u r o t e n s i n i n rats. (Abstract# G4822) GL Schmidt, AM Karinch and GL Kauffman, Jr. Hershey, PA B r a i n s t e m n i t r i c oxide protects a g a i n s t s t r e s s - i n d u c e d gastric u l c e r f o r m a t i o n i n the rat. (Abstract# G4731) ZK Krowicki, DV Sivara0 and PJ Hornby. New Orleans, LA M e l a t o n i n a n d its s u b s t r a t e L - t r y p t o p h a n accelerate the h e a l i n g of c h r o n i c gastric ulcers. Role of p r o s t a g l a n d i n s , n i t r i c oxide a n d g a s t r i n . (Abstract# G4629) T Brzozowski, PC Konturek, S Kwiecie~, W Bielariski, R Pajdo, I Brzozowska, SJ Konturek and EG Hahn. Krakow, Poland and Erlangen, Germany

DDW Poster of Distinction:

H y p o t h y r o i d i s m increases the n u m b e r of Fos i m m u n o r e a c t i v e n e u r o n s i n the d o r s a l m o t o r n u c l e u s of t h e vagus, n u c l e u s t r a c t u s s o l i t a r i u s a n d area postrema. (Abstract# G4884) PQ Yuan, Y Tach~ and H Yang. Los Angeles, CA

S t r e s s - i n d u c e d i n h i b i t i o n of gastric a n d s t i m u l a t i o n of colonic m o t o r f u n c t i o n i n v o l v e d CRF i n t e r a c t i o n with different r e c e p t o r s u b t y p e s i n rats. (Abstract# G4786) T Nozu, GP Chrousos, EL Webster, KC Rice and Y TachS. Los Angeles, CA and Bethesda, MD

N - d e s m e t h y l t r i m e b u t i n e p r e v e n t s visceral paini n d u c e d c-fos e x p r e s s i o n i n the r a t s p i n a l cord. (Abstract# G4829) V Sinniger, B B0naz, M Ch0vet, C Lamy, J Fournet and C Feuerstein. Paris, Grenoble and Fresnes, France

I n t r a c i s t e r n a l or m i c r o i n j e c t i o n of TRH i n t o DMN does not activate non-adrenergic, non-cholinergic inhibitory n e u r o n s of the r a t stomach. (Abstract# G3337) T Nozu, HE Raybould, N Morrow, T Garrick and Y TachS. Los Angeles, CA

I n c r e a s e d activity of h y p o t h a l a m i c 5-HT i n a n o r e x i a i n d u c e d b y e x p e r i m e n t a l colitis. (Abstract# G4607) AB Ballinger, T Elhaj, J Turvill, G Williams and MJG Farthing. London and Liverpool, United Kingdom

DDW Poster of Distinction: P e r i p h e r a l u r o c o r t i n - a n d C R F - i n d u c e d gastric stasis: role of CRF 2 r e c e p t o r s u b t y p e i n rats. (Abstract# G3338) T Nozu, V Martfnez, J River and Y TachS. Los Angeles and La Jolla, CA C e n t r a l c o r t i c o t r o p i n - r e l e a s i n g factor decreases t h e h e p a t i c blood flow i n rats. (Abstract# G4778) Y Nakade, M Yoneda, S Takamot0, S Yokohama, K Tamori, K Aso, Y Sat0, M Aoshima, K Nakamura and I Makino. Asahikawa, Japan Glucagon-like-peptide-1 acts via dorsal vagal complex to i n h i b i t p a n c r e a t i c e n z y m e secretion. (Abstract# G4741) Y Li, JX Zhu, E Rillamas, F Nozu and C Owyang. Ann Arbor, MI I n t r a c e r e b r o v e n t r i c u l a r i n j e c t i o n of glucagon-like peptide-1 i n h i b i t s gastric acid secretion i n conscious rats. (Abstract# G4657) T Coskun, A Bozkurt, N Imeryiiz, BC Yegen and NB Ulusoy. Istanbul, Turkey

Differences i n a n t i n o c i c e p t i v e r e s p o n s e s to colorectal d i s t e n s i o n b e t w e e n different r a t s t r a i n s . (Abstract# G4697) JM Gschossmann, JC Miller, M Mulugeta, SH Cheng, V Martinez, Y Tach~ and EA Mayer. Los Angeles, CA Evidence for role of vagal i n n e r v a t i o n i n a c t i v a t i o n of opioidergic a n t i n o c i c e p t i v e s y s t e m s i n response to colorectal d i s t e n s i o n i n rats. (Abstract# G4698) JM Gschossmann, JC Miller and EA Mayer. Los Angeles, CA A c t i v a t i o n of h i s t a m i n e r g i c n e u r o n i n the h u m a n b r a i n b y b a l l o o n d i s t e n t i o n of the colon. (Abstract# G4676) S Fukudo, K Yanai, M Higuchi, M Kanazawa, T Nomura, M Satake, T Sugawara, T Shoji, K Karahashi, Y Endo, T Watanabe and M Hongo. Sendal, Japan N e u r a l correlates of visceral p a i n : a n fMRI study. (Abstract# G4625) B Bonaz, E Papillon, M Baciu-Raybaudi, R Bost, JF Le Bas, C Segebarth and J Fournet. Grenoble, France

P92 PROGRAM OF THE ANNUAL MEETING

S p i n a l a n d p e r i p h e r a l k a p p a a n d m u opioid r e c e p t o r agonists i n h i b i t the r e s p o n s e to n o x i o u s colorectal d i s t e n s i o n . (Abstract# G4639) N Castex, B Levine, T Vanderah, JL Junien, F Porreca and PJM Riviere. Tucson, AZ; San Diego, CA and Gentilly, France D e t e c t i o n of CCK-8-indueed c e r e b r a l n e u r o n a l activities b y f u n c t i o n a l m a g n e t i c r e s o n a n c e i m a g i n g i n h u m a n s . (Abstract# G4723) M Kern, K Saeian, R Arndorfer, L Eskowski, E Stein, A Bloom, J Hyde and R Shaker. Milwaukee, WI

DDW Poster of Distinction: C h o l e c y s t o k i n i n - r e s p o n s i v e gastric vagal afferents i n ~ ' t r o i n rats. (Abstract# G4863) YH Wang, Y Tach~ and JY Wei. Los Angeles, CA The a n o r e x i g e n i c p e p t i d e CCK s t i m u l a t e s p l a s m a l e p t i n i n t h e rat. (Abstract# G4605) S Attoub, S Levasseur, J-P Laigneau, L Moizo, H Go~ot, P Artru, MJM Lewin and A Bado. Paris, France

GASTROENTEROLOGY Vol. 114~ No. 4

P r a v a s t a t i n decreases b i l i a r y cholesterol s e c r e t i o n b y a m e c h a n i s m i n d e p e n d e n t of cholesterol s y n t h e s i s i n h i b i t i o n i n h e a l t h y h u m a n s . (Abstract# L0349) K Lange, G Kallien, EF Stange and J Scheibner. Luebeck, Germany Mechanism a n d r e g u l a t i o n of r i b o f l a v i n u p t a k e b y the h u m a n - d e r i v e d liver cells Hep G2. (Abstract# L0540) HM Said, A Ortiz and TY Ma. Long Beach and Irvine, CA The effects of c u r c u m i n o n i o n t r a n s p o r t a n d m u s c l e c o n t r a c t i o n i n r a t distal colon. (Abstract# L0487) M On0mura, H Tsukada, M Hosokawa, H Nakamura, K Fukuda, T Saitou, T K0dama and Y Seino. Ky0to, Japan

DDW Poster of Distinction: I n c r e a s e d s e n s i t i v i t y of h u m a n a p o l i p o p r o t e i n A-I to c a r b o x y t e r m i n a l proteolysis. (Abstract# L0571) H Schmidt, R Haas, J Genschel, S Wagner, C Strassburg, C Biittner and M Manns. Hannover, Germany AASLD - - G E N E T I C LIVER DISEASE AND G E N E THERAPY

AASLD Poster Session

8:00-5:00 p m

Hall D Ernest N. Morial Convention Center

Authors are required to present during the Poster Session from 12:00-2:30 pm

Those posters identified as DDW Posters of Distinction have received review scores that place them within the top 10% of all posters. We encourage you to make them a priority as you visit the poster session. AASLD - - LIPIDS AND VITAMINS Effect of the v a r i a n t a p o l i p o p r o t e i n allele A-IV-2 on p o s t p r a n d i a l p l a s m a l i p i d clearance. (Abstract# L0241) KJ Hockey, RA Anderson and RB Weinberg. WinstonSalem, NC I n d u c t i o n of fatty acid b i n d i n g p r o t e i n s t i m u l a t e s the cytoplasmic diffusion of h e p a t i c f a t t y acids. (Abstract# L0391) BA Luxon and MT Millian0. St Louis, MO D e l i n e a t i o n of a n o v e l h e p a t i c r o u t e for the selective t r a n s f e r of u n e s t e r i f i e d sterols from HDL to bile. (Abstract# L0532) SJ Robins and JM Fasulo. Boston, MA Oxidized low d e n s i t y l i p o p r o t e i n activates lipid s i g n a l i n g p a t h w a y s i n m a c r o p h a g e s . (Abstract# L0200) A Gomez-Mufioz, J Martens, N Reiner and UP Steinbrecher. Vancouver, Canada The feedback r e g u l a t i o n of cholesterol a n d bile acid synthesis b y d i e t a r y cholesterol is i n d e p e n d e n t l y expressed i n r a b b i t s . (Abstract# L0693) G Xu, G Salen, S Shefer, GS Tint and LB Nguyen. East Orange and Newark, NJ D i e t a r y c a m p e s t a n o l is p o o r l y a b s o r b e d a n d does n o t a c c u m u l a t e w h e n fed to r a b b i t s . (Abstract# L0692) G Xu, G Salen, AK Batta, GS Tint and S Shefer. East Orange and Newark, NJ E s s e n t i a l role of Mdr2P-glycoprotein i n r e g u l a t i o n of h e p a t i c activities of m a j o r cholesterol r e g u l a t o r y enzymes. (Abstract# L0348) F Lammert, MR Leonard, DQ-H Wang, B Paigen and MC Carey. Boston, MA and Bar Harbor, ME

C h a r a c t e r i z a t i o n of novel m u t a t i o n s i n f a m i l i a l hypercholesterolemia. (Abstract# L0570) H Schmidt, M Stuhrmann, T D~rk, R Haas, U Tietge, M Ebhard, J Schmidtke and M Manns. Hannover, Germany A novel stop codon m u t a t i o n of t h e f e r r o c h e l a t a s e gene i n bovine p r o t o p h o r p h y r i a , a n a t u r a l a n i m a l model of the h u m a n disease. (Abstract# L0277) MM Jenkins, RD LeBoeuf, GR Ruth and JR Bloomer. Birmingham, AL and Minnesota, MN M u t a t i o n a n a l y s i s i n J a p a n e s e p a t i e n t s w i t h Wilson's disease. (Abstract# L0592) Y Shiono, T Okada, Y Takeda, H Hayashi, H Hamano, A Suzuki, T Morise, H Mabuchi and M Yano. Ishikawa and Aichi, Japan Mechanisms of action of zinc s u l p h a t e i n t h e t r e a t m e n t of Wilson's disease. (Abstract# L0419) C Mestriner, R D'Inc~, P Irat0, V Albergoni, G L0ngo, V Di Leo and GC Sturniolo. Padua, Italy Incomplete p e n e t r a n c e for h e m o c h r o m a t o s i s : a gene i n search of a disease? (Abstract# L0004) PC Adams and S Chakrabarti. London, Canada Non-alcoholic s t e a t o h e p a t i t i s a n d h e r e d i t a r y hemochromatosis. (Abstract# L0274) Q Jawaid, P Leclair, K T0rt0relli, J Cobb, R Lambrecht and H B0nk0vsky. Worcester, MA Liver biopsy versus genetic t e s t i n g for t h e C282Y m u t a t i o n : a c o m p a r i s o n of d i a g n o s t i c s t r a t e g i e s for h e r e d i t a r y h e m o c h r o m a t o s i s u s i n g decision analysis. (Abstract# L0580) NJ Shaheen, MH Braun, IS Grimm, RS Sandler, SM Downs and BR Bacon. Chapel Hill, NC and St Louis, MO A novel association b e t w e e n m i c r o v e s i c u l a r s t e a t o h e p a t i t i s a n d a c o m m o n m u t a t i o n i n t h e ~oxidation cycle. (Abstract# L0252) JA Ibdah, MJ Bennett, P Rinaldo and AW Strauss. WinstonSalem, NC; Dallas, TX; New Haven, CT and St Louis, MO Development of a n efficient n o n v i r a l gene t r a n s f e r m e t h o d to hepatocytes u s i n g cationic liposome a n d ursodeoxycholic acid. (Abstract# L0625) K Tada, H Minami, Y Oka, H Iuchi, SMF Akbar, N Horiike, N Roy Chowdhury, J Roy Chowdhury and M Onji. Ehime, Japan and New York, NY

April 1998

11

PROGRAM O F T H E ANNUAL MEETING P93

A A S L D P O S T E R S E S S I O N m M O N D A Y , M A Y 18, 1998

R e t r o v i r a l p s e u d o t y p i n g w i t h S e n d a l v i r u s F protein: a n a s i a l o g l y c o p r o t e i n r e c e p t o r specific liver gene t r a n s f e r system. (Abstract# L0602) M Spiegel, M Bitzer, M Gregor and U Lauer. Tubingen, Germany Apoptosis is a m e c h a n i s m of Sendal v i r u s - i n d u c e d cell i n j u r y : i m p l i c a t i o n s for the g e n e r a t i o n of S e n d a l v i r u s vectors for l i v e r gene t h e r a p y . (Abstract# L0058) M Bitzer, F Prinz, M Spiegel, WJ Neubert, M Greg0r and U Lauer. Tubingen and Martinsried, Germany H e p a t o t r o p i c t r a n s d u c t i o n b y Sendai v i r u s vectors. (Abstract# L0059) M Bitzer, S Leyrer, R Sedlmeier, M Spiegel, M Gregor, WJ Neubert and U Lauer. Tubingen and Martinsried, Germany

Changes of p o r t a l blood flow w h i l e b r e a t h - h o l d i n g after i n s p i r a t i o n or e x p i r a t i o n c o m p a r e d with d u r i n g n o r m a l respiration using magnetic resonance imaging in controls a n d cirrhotics. (Abstract# L0612) S Sugan0, M Watanabe, S Sasao, N Takamura, K Ishii and K Yamamoto. Yokohama, Japan E v a l u a t i o n of r e g i o n a l l i v e r f u n c t i o n by g a d o l i n i u m EOB-DTPA e n h a n c e d MR i m a g i n g . (Abstract# L0590) J Shimizu, K D0n0, M G0toh, Y Hasuike, T Kim, T Murakami, M Sak0n, K Umeshita, H Nagano, S Nakam0ri, N Kato, T Miyazawa, H Nakamura and M M0nden. Osaka, Japan AASLD - - PORTAL H Y P E R T E N S I O N AND COMPLICATIONS OF CIRRHOSIS

A critical role of the liver i n i n d u c i n g oral t o l e r a n c e to a d e n o v i r a l vectors for l o n g t e r m gene therapy. (Abstract# L0260) Y Ilan, N Roy Chowdhury, BS Sauter, NR Thummala, A Davidson, MS Horwitz, J Nakamura, IJ Fox and J Roy Chowdhury. New York, NY and Omaha, NE

DDW Poster of Distinction:

A d e n o v i r u s - m e d i a t e d s y n t h e s i s of r e c o m b i n a n t bilirubin UDP-glucuronosyltransferasepermits a c o m p a r i s o n of i n t r a c e l l u l a r gene t h e r a p y a n d e x t r a c e l l u l a r p r o t e i n r e p l a c e m e n t therapy. (Abstract# L0371) H Li and FK Askari. Ann Arbor, MI

Does endoscopic t r e a t m e n t of esophageal varices, with s c l e r o t h e r a p y or ligation, i n f l u e n c e the e v o l u t i o n of portal hypertensive gastropathy in cirrhotic patients? (Abstract# L0517) M Primignani, M Materia, P Preatoni, A Carta, T Morbin, G Battaglia and R de Franchis. Milan and Padua, Italy

AASLD m H E P A T I C BLOOD FLOW

Variceal inflow vessels a n d t h e d e v e l o p m e n t of p o r t a l h y p e r t e n s i v e g a s t r o p a t h y after endoscopic l i g a t i o n t h e r a p y for esophageal varices. (Abstract# L0214) A Hachiya, T Yoneya, S Nakano, M Katagiri, E Kanda, T Kurita, E Kondo, S Yamada, H Matsuzaki and S Otsuka. Tokyo, Japan

DDW Poster of Distinction: E x p r e s s i o n s of e n d o t h e l i n r e c e p t o r s u b t y p e p r o t e i n s a n d mRNA i n h u m a n liver. (Abstract# L0699) H Yokomori, M Oda, Y Yasogawa, Y Kamegaya, H Yokono, M Ogi, M Nakamura, N Tsukada and H Ishii. Saitama and Tokyo, Japan New i n s i g h t s i n t o t h e p a t h o g e n e s i s of ischemic h e p a t i t i s . (Abstract# L0575) RK Seeto, B Fenn and DC Rockey. San Francisco, CA and Durham, NC Role of r e a c t i v e oxygen i n t e r m e d i a t e s i n t h e m y o c a r d i a l i n j u r y of l i v e r cirrhosis. (Abstract# L0639) G Therapondos, JN Plevris, R Dawkes, MM Dollinger, AD Flapan and PC Hayes. Edinburgh, Scotland

Risk factors associated w i t h r e b l e e d i n g a n d r e c u r r e n c e following endoscopic v a r i c e a l ligation. (Abstract# L0360) JH Lee, SY Oh, KC Koh, PL Rhee, J Kim, JC Rhee and KW Choi. Seoul, Korea

A n e w c o m b i n e d t h e r a p e u t i c m e t h o d for esophageal varices; endoscopic variceal l i g a t i o n followed b y mucosa-fibrosing with microwave. (Abstract# L0242) K Hokari, M Kato, M Katagiri, Y Komatsu, F Sato, M Sukegawa, H Kagaya, K Nishikawa, H Takeda, T Sugiyama and M Asaka. Sapporo, Japan Long t e r m r e s u l t s of elective t h e r a p e u t i c p o r t a c a v a l s h u n t for b l e e d i n g esophagogastric varices i n 1000 p a t i e n t s w i t h cirrhosis. (Abstract# L0490) MJ Orloff, MS Orloff, SL Orloff and B Girard. San Diego, CA; Rochester, NY and Portland, OR

5,10-methylenetetrahydrofolate r e d u c t a s e 677 C->T m u t a t i o n m a y be a g e n e t i c r i s k factor i n Budd-Chiari s y n d r o m e . (Abstract# L0556) H Satoh, T Okada, Y Takeda, H Aoyagi, Y Nishida, T Kawashiri, K Kaginami and H Mabuchi. Ishikawa, Japan

DDW Poster of Distinction:

Perioperative bactericidal/permeability-increasing p r o t e i n (rBP123) i m p r o v e s the decrease i n total h e p a t i c flow after p a r t i a l h e p a t e c t o m y . (Abstract# L0061) MA Boermeester, APJ Houdijk, S Meyer and PAM van Leeuwen. Amsterdam, The Netherlands

Relationship between esophageal variceal bleeding and p o r t a l s h u n t i n d e x e v a l u a t e d b y p e r rectal p o r t a l s c i n t i g r a p h y i n cirrhotic p a t i e n t s . (Abstract# L0U0) T Chitapanarux, K Phornphutkul, O-A Praisontarangkul, S Boonyaprapa and S Thongsawat. Chiang Mai, Thailand

R e l a t i o n s h i p b e t w e e n p o r t a l v e i n blood flow m e a s u r e d by image-directed Doppler ultrasonography and h e p a t i c blood flow m e a s u r e d b y sorbitol clearance. (Abstract# L0634) D Tauschek, D Becket, C Her01d, D Strobel, M Wehler, T Schneider and EG Hahn. Erlangen-Nuremberg, Germany

Meta-analysis of endoscopic a n d m e d i c a l t r e a t m e n t r e g i m e n s i n active variceal bleeding. (Abstract# L0207) M Gross, A Miihlh6fer and WG Zoller. Munich, Germany

P r o p h y l a c t i c endoscopic v a r i c e a l l i g a t i o n with m u l t i p l e b a n d ligator for esophageal varices. (Abstract# L0104) CY Chen, MZ Sheu and SY Su. Chia-Yi, Taiwan

C o m p a r i s o n of endoscopic v a r i c e a l s c l e r o t h e r a p y with s e q u e n t i a l b a n d ligation a n d low dose s c l e r o t h e r a p y for s e c o n d a r y p r o p h y l a x i s of v a r i c e a l h e m o r r h a g e : a prospective r a n d o m i z e d trial. (Abstract# L0190) PK Garg, YK J0shi and RK Tandon. New Delhi, India

GASTROENTEROLOGYVol.114r No. 4

P94 PROGRAM OF THE ANNUAL MEETING II

AASLD

POSTEI~

SESSION

-- MONDAY)

MAY

18, 1998

T I P S c o m p a r e d w i t h e n d o s c o p i c t r e a t m e n t for t h e p r e v e n t i o n of r e c u r r e n t v a r i c e a l b l e e d i n g . A metaa n a l y s i s of r a n d o m i z e d c o n t r o l l e d t r i a l s . (Abstract# L0500) TM Pasha and PS Kamath. Scottsdale, AZ and Rochester, MN

Proton magnetic resonance spectroscopy findings in cirrhotic patients without hepatic encephalopathy: does t h e m y o i n o s i t o l / c r e a t i n e r a t i o r e f l e c t h e p a t i c f u n c t i o n a l r e s e r v e ? (Abstract# L0576) DW Seo, Y-S Lee, GC Lee, NH Park, JH Lee, T-H Lira, DJ Suh and YI Min. Seoul, Korea

E s t i m a t i o n of T I P S b l o o d flow b y i n t r a v a s c u l a r a n d p e r c u t a n e o u s u l t r a s o u n d . (Abstract# L0690) U Wruck, P Romaniuk, B Sha'ath, B GaSmann, A-E Roske, T Schiitz, W Wermke, H Lochs and M Plauth. Berlin, Germany

Acute a n d c h r o n i c h e m o d y n a m i c a n d r e n a l effects of c a r v e d i l o l in c i r r h o s i s . (Abstract# L0603) AJ Stanley, G Therapondos, A Salem and PC Hayes. Edinburgh, Scotland

S c h e d u l e d follow-up to d e t e c t s t e n o s i s r e s u l t s in improved outcome of transjugular intrahepatic portal s h u n t . (Abstract# L0176) S Fredstrom, H Bjarnas0n, DW Hunter, GK Nazarian, C Anderson, GJ DeMuth and J Rank. Minneapolis, MN D e t e r m i n a n t s of s u r v i v a l f o l l o w i n g i n t r a h e p a t i c p o r t a s y s t e m i c s h u n t : a m u l t i v a r i a t e analysis. (Abstract# L0095) N Chalasani, J Kamean, LG Martin, WS Clark and TD Boyer. Atlanta, GA

N o n i n v a s i v e h e m o d y n a m i c m e a s u r e m e n t s of s u p e r i o r m e s e n t e r i c a r t e r y i n t h e p r e d i c t i o n of p o r t a l p r e s s u r e r e s p o n s e to p r o p r a n o l o l . (Abstract# L0645) A T0yonaga, T Iwa0, K Oh0, T Sakai, M Sato, R Nakan0, M Yamawaki and K Tanikawa. Kurume, Japan R e l a t i o n b e t w e e n p o r t a l p r e s s u r e a n d b l o o d flow d e p e n d e n t on t h e d e g r e e of p o r t a l h y p e r t e n s i o n in p a t i e n t s w i t h l i v e r c i r r h o s i s a n d TIPS. (Abstract# L0563) P Schiedermaier, K-A Brensing and T Sauerbruch. Bonn, Germany

A p r e d i c t i v e i n d e x for d e t e r m i n i n g t h e r i s k for p r e s e n c e of l a r g e e s o p h a g e a l v a r i c e s i n p a t i e n t s w i t h c i r r h o s i s . (Abstract# L0094) N Chalasani, T Imperiale, A Ismail, G So0d, CM Wilcox, P Kwo, L Lumeng, H Madichetty, M Carey and TD Boyer. Indianapolis, IN and Birmingham, AL

DDW Poster of Distinction:

DDW Poster of Distinction:

R i s k f a c t o r s of h e p a t i c v e n o o c c l u s i v e d i s e a s e i n b o n e m a r r o w t r a n s p l a n t p a t i e n t s as d i a g n o s e d b y B a l t i m o r e Clinical Diagnostic C r i t e r i a . (Abstract# L0055) A Bilici, H Bolukoglu, TK ConneU, J Galati, C Ahn, R Champlin, G Glober and V Ankoma-Sey. Houston, TX

Somatostatin plus isosorbide-5-mononitrate versus s o m a t o s t a t i n i n t h e c o n t r o l of a c u t e g a s t r o e s o p h a g e a l v a r i c e a l b l e e d i n g : a r a n d o m i z e d c o n t r o l l e d trial. (Abstract# L0282) F Junquera, JC L6pez-Talavera, F Mearin, E Saperas, JR Armengol, R Esteban and J-R Malagelada. Barcelona, Spain L o n g t e r m h e m o d y n a m i c a n d e n d o c r i n e effects of o c t r e o t i d e on p o s t p r a n d i a l h y p e r e m i a in c o n t r o l s a n d c i r r h o t i c p a t i e n t s : r a n d o m i z e d , double-blind, placeboc o n t r o l l e d e c h o - D o p p l e r s t u d y . (Abstract# L0390) D Ludwig, A Briining, S Terai, S Schaedel, A Feddersen and EF Stange. Liibeck, Germany S p l a n c h n i c a n d s y s t e m i c h e m o d y n a m i c effects of l a u r e o t i d e i n p a t i e n t s w i t h a l c o h o l i c cirrhosis. (Abstract# L0037) K Barange, JM Peron, F Oberti, JM Combis, J Sanchez, JL Payen, P Cales, JP Pascal and JP Vinel. d'Angers, France A s s e s s m e n t of s u b c l i n i c a l h e p a t i c e n c e p h a l o p a t h y a f t e r transjugular portosystemic stenting in patients with liver cirrhosis using cognitive evoked brain potentials (P300) a n d 1H-MRI s p e c t r o s c o p y . (Abstract# L0244) S Hollerbach, F Kullmann, A Geissler, R Friind, M Wimmer, E Busch, J SchSlmerich and G Lock. Regensburg, Germany A m m o n i a a n d 1,4-benzodiazepines i n e n c e p h a l o p a t h i c p a t i e n t s w i t h f u l m i n a n t h e p a t i c failure. (Abstract# L0710) ML Zeneroli, I Venturini, L C0rsi, R Avallone, F Farina, G Ardizzone, M Centanaro, A Arrig0, L Migli01i, P Schreier, M Kleinschnitz and M Baraldi. Modena and Genoa, Italy; Wuerzburg, Germany F o o d a n d b a c t e r i a l f l o r a a r e s o u r c e s of b e n z o d i a z e p i n e l i k e c o m p o u n d s . (Abstract# G3754) ML Zener01i, I Venturini, S Stefanelli, F Farina, A Ferrieri, L Corsi, R Avallone, R Cosenza and M Baraldi. Modena and Bologna, Italy

)l

C e n t r a l s p l a n c h n i c v e i n t h r o m b o s i s is m o s t often r e l a t e d to a n t i - c a r d i o l i p i n a n t i b o d y s y n d r o m e o r h i g h p l a s m a h o m o c y s t e i n e levels. (Abstract# L0140) TK Desai, J Hendrick, B Gelzayd, F Wilner and P DeRidder. Royal Oak, MI

P r e d i c t o r s of h e p a t i c v e n o o c c l u s i v e d i s e a s e a f t e r b o n e m a r r o w t r a n s p l a n t a t i o n - case d e f i n i t i o n b a s e d on S e a t t l e Criteria. (Abstract# L0054) A Bilci, H Bolukoglu, TK Connell, J Galati, C Ahn, R Champlin, G Glober and V Ankoma-Sey. Houston, TX L a r g e volume p a r a c e n t e s i s m a y b e safely p e r f o r m e d i n s u b j e c t s w i t h s u g g e s t e d c o n t r a i n d i c a t i o n s to t h e p r o c e d u r e . (Abstract# L0154) DJ D0wling, A Grant and J Neuberger. Birmingham, United Kingdom R o u t i n e a n a l y s i s of a s c i t i c f l u i d a t t h e t i m e of l a r g e volume p a r a c e n t e s i s i n a s y m p t o m a t i c o u t p a t i e n t s is u n n e c e s s a r y . (Abstract# L0276) MA Jeffries, MA Stern, NT Gunaratnum and RJ Fontana, Ann Arbor, MI The u s e of r e c o m b i n a n t f a c t o r VIIa i n l a p a r o s c o p i c liver biopsy: a p i l o t t r i a l . (Abstract# L0275) LJ Jeffers, DE Bernstein, E Erhardsten, W Acebo, KR Reddy, RM Bech and ER Schiff. Miami, FL; Mineola, NY and Copenhagen, Denmark P r o g n o s t i c v a l u e of w e d g e d h e p a t i c v e i n p r e s s u r e g r a d i e n t following a n i n d e x v a r i c e a l h e m o r r h a g e . (Abstract# L0307) S Khan, A Owen, F Williamson, N Roberts, SA Jenkins and R Sutton. Liverpool, United Kingdom R o u t i n e m e a s u r e s to d e t e r m i n e p r o g n o s i s a f t e r a n i n d e x b l e e d in c i r r h o t i c p o r t a l h y p e r t e n s i o n . (Abstract# L0308) S Khan, A Owen, P Williamson, N Roberts, SA Jenkins and R Sutton. Liverpool, United Kingdom

April 1998

II

P R O G R A M OF THE ANNUAL MEETING P 9 5

A A S L D P O S T E R S E S S I O N - - M O N D A Y , MAY 18, 1998

L o n g t e r m p r o g n o s t i c s i g n i f i c a n c e of t e s t s of encephalopathy in cirrhotic portal hypertension. (Abstract# L0306) S Khan, A Owen, P Williamson, N Roberts, SA Jenkins and R Sutton. Liverpool, United Kingdom Portal venous pressure and portal venous pressure gradient are similar in patients with refractory ascites a n d r e c u r r e n t v a r i c e a l bleeding. (Abstract# L0667) K Wadwa, SW Paik, A Venbrux, F Osterman, S Mitchell, S Savader, G Lund and PJ Thuluvath. Baltimore, MD C h a n g e s i n v a r i c e a l p r e s s u r e d e t e r m i n e d noni n v a s i v e l y b y e n d o s c o p i c b a l l o o n m a n o m e t r y p r i o r to a n d a f t e r p o r t a l d e c o m p r e s s i o n b y TIPS-insertion. (Abstract# L0070) KA Brensing, C Scheurlen, M Neubrand, P Sehiedermaier, P Raab and T Sauerbruch. Bonn, Germany E n d o s c o p i c u l t r a s o u n d in c i r r h o s i s : p r e v a l e n c e of f i n d i n g s i n c o m p a r i s o n w i t h h e a l t h y controls. (Abstract# L0165) DO Faigel, HR Rosen, AW Sasaki, K Flora and K Benner. Portland, OR I m p l i c a t i o n of p e r i e s o p h a g e a l - a n d p a r a e s o p h a g e a l collateral veins observed by endoscopic u l t a s o n o g r a p h y in p o r t a l h y p e r t e n s i o n . (Abstract# L0263) A Irisawa, K Obara, H Sakamoto, F Takiguchi, A Saito, H Shishido, M Ito, Y Sato and R Kasukawa. Fukushima, Japan

DDW Poster of Distinction: E s t i m a t i o n of b o d y cell m a s s i n l i v e r c i r r h o s i s : c o m p a r i s o n of m u l t i f r e q u e n c y b i o e l e c t r i c i m p e d a n c e a n a l y s i s a n d t o t a l b o d y p o t a s s i u m counting. (Abstract# L0512) M Pirlich, X Ertel, T Spachos, T Schlitz, A-E Roske, ML WeiB, H Lochs and M Plauth. Berlin, Germany S e r u m t h r o m b o p o i e t i n level r e g u l a t e d b y p o r t a l h e m o d y n a m i c s i n l i v e r c i r r h o s i s . (Abstract# L0240) K Hisatomi, S Sezai, A Ishikawa, M Ito, Y Sakurai and K Kamisaka. Tokyo, Japan

DDW Poster of Distinction:

S c l e r o t h e r a p y of b l e e d i n g g a s t r i c v a r i c e s w i t h c y a n o a c r y l a t e in c h i l d r e n . (Abstract# L0186) S Fuster, A Costaguta and O Tabacco. Rosario, Argentina E n d o s c o p i c s c l e r o t h e r a p y of e s o p h a g e a l v a r i c e s in c h i l d r e n : t e n y e a r s follow-up a f t e r e r a d i c a t i o n . (Abstract# L0057) M Bini, A Rossi, C Grosso, P Gambitta, G Zanasi, Z Pirone and R Arcidiacono. Milan, Italy AASLD - - VIRAL H E P A T I T I S C: P A T H O G E N E S I S AND I M M U N O L O G Y

DDW Poster of Distinction: Genetic immunization generates broad based cellular and humoral immune responses against the n o n s t r u c t u r a l p r o t e i n s of h e p a t i t i s C virus. (Abstract# L0162) J Encke, J zu Putlitz, M Geissler and JR Wands. Charlestown, MA

DDW Poster of Distinction: D i s t r i b u t i o n a n d h e t e r o g e n e i t y of l i v e r - i n f i l t r a t i n g CD56-positive T l y m p h o c y t e s in c h r o n i c h e p a t i t i s r e l a t e d to h e p a t i t i s C v i r a l infection. (Abstract# L0253) T Ichida, K Sato, K Yonekura, S Yamagiwa, S Sugahara, M Uchida, T Abo and H Asakura. Niigata, Japan CD8+ l y m p h o c y t e r e s p o n s e s i n a c u t e a n d c h r o n i c h e p a t i t i s C v i r u s infection. (Abstract# L0115) JML Christie, K Fleming, RW Chapman and WMC Rosenberg. Oxford and Southampton, United Kingdom Effects of HCV c o r e - d e r i v e d T h e l p e r l i p o p e p t i d e s on HCV specific l y m p h o c y t e p r o l i f e r a t i o n . (Abstract# L0350) B Langhans, I Braunschweiger, S Schweitzer, W GraB, G Jung, T Sauerbruch and U Spengler. Bonn and TObingen, Germany D i f f e r e n t i a l T cell s u b s e t a c t i v a t i o n in p a t i e n t s w i t h d i f f e r e n t outcomes of h e p a t i t i s C. (Abstract# L0687) RP Woitas, M Sippel, HH Brackmann, T Sauerbruch and U Spengler. Bonn, Germany

Does a d r e n o m e d u l l i n p l a y a r o l e in p o r t a l h y p e r t e n s i v e g a s t r i c m u c o s a ? (Abstract# L0642) M T0mikawa, H Wang, MK Jones, K Sugimachi, IJ Sarfeh, R Itani and AS Tarnawski. Long Beach and Irvine, CA; Fukuoka, Japan

RIBA-3 HCV-positive/PCR-negative p a t i e n t s h a v e T cell i m m u n i t y i n d i c a t i n g p r i o r infection. (Abstract# L0713) IM Zitron, M Laurinaitis, A Nicolopoulos, AL Sflverman, M De Medina and SC Gordon. Royal Oak, MI and Miami, FL

Gene t r a n s f e r of ceNOS i n d u c e s l o n g t e r m c o n t r o l of p o r t a l h y p e r t e n s i o n i n CCI 4 c i r r h o t i c r a t s . (Abstract# L0485) AK Omasta, SP Janssens, T Roskams, M Van De Castelle, G Van Roey, F Nevens and J Fevery. Leuven, Belgium

D e c r e a s e d efficacy of h e p a t i t i s B v a c c i n e in p a t i e n t s w i t h c h r o n i c h e p a t i t i s C. (Abstract# L0053) F Berr, UG Liebert, U Oesen, H Porst, M Wiese, M Wiedmann, H Krieger and J MSssner. Chemnitz, Dresden and Leipzig, Germany

Transmesenteric transfemoral intrahepatic p o r t o s y s t e m i c s h u n t : p r e d i c t o r s of i n - h o s p i t a l outcome. (Abstract# L0338) R Krishan, U Raghuraman, B Ouseph, E Ch0u, D Rea, E Lebovics, G Rosenblit, M P0plausky, J Rundback, LRM DelGuercio, B Dw0rkin, W Rosenthal and DC Wolf. Valhalla, NY

Immunoglobulin allotypes and hepatitis C virus infection. (Abstract# L0525) C Rat, O Goria, M Doffoel, JP Vinel, M Daveau, JM Dugoujon and E Lerebours. Rouen, Strasbourg and Toulouse, France

DDW Poster of Distinction:

What predicts survival in cirrhotics undergoing transjugular intrahepatic portosystemic shunt? I n d i a n a U n i v e r s i t y e x p e r i e n c e . (Abstract# L0304) A Khan, T Imperiale, P Kwo, L Born, N Chalasani, N Patel and L Lumeng. Indianapolis, IN

Genetic c h a n g e s of i n t e r f e r o n s e n s i t i v i t y d e t e r m i n i n g r e g i o n of HCV d u r i n g t h e n a t u r a l c o u r s e of c h r o n i c h e p a t i t i s C. (Abstract# L0394) S Maekawa, N En0moto, M Kur0saki, N Sakam0t0, T Fukuma, I Sakuma, K Nagayama, F Maruno and C Sat0. Tokyo, Japan

P96 P R O G R A M OF T H E A N N U A L M E E T I N G

G A S T R O E N T E R O L O G Y Vol. 114~ No. 4 fl

h

II I!

AASLD POSTER SESSION - - MONDAY, MAY 18, 1998

The e x p r e s s i o n of i n t e r f e r o n - a l p h a r e c e p t o r mRNA i n liver biopsies of p a t i e n t s w i t h c h r o n i c h e p a t i t i s C. (Abstract# L0402) J Mathai, K Shimoda and GF Barnard. Worcester, MA

Hepatitis C v i r u s is r e s p o n s i b l e for h y p e r m e t a b o l i s m i n p a t i e n t s w i t h c h r o n i c h e p a t i t i s C. (Abstract# L0511) T Piche, S Schneider, S H~buterne, G Dreyfus, A Tran, S Dantin and P Rampal. Nice and Neuilly-sur-Seine, France

Different IL-12 p40 r e s p o n s e i n p a t i e n t s w i t h h e p a t i t i s C v i r u s - i n d u c e d c i r r h o s i s a n d alcoholic cirrhosis. (Abstract# L0219) C Hanck, MV Singer and S Rossol. Mannheira, Germany

The C282Y m u t a t i o n is n o t a s i g n i f i c a n t cofactor for more severe l i v e r disease i n a cohort of I r i s h h e p a t i t i s C patients. (Abstract# L0042) S Barrett, G Callagy, E Ryan, JC O'Keane, P MacMathuna and J Crowe. Dublin, Ireland

Class I a n d II e x p r e s s i o n a n d c y t o k i n e release after a n t i g e n challenge is a b n o r m a l i n p a t i e n t s w i t h c h r o n i c h e p a t i t i s C. (Abstract# L0585) ML Shiffman, C Rhodes and P Kimball. Richmond, VA I d e n t i f i c a t i o n of c e l l u l a r p r o t e i n s t h a t b i n d selectively to t h e c o n s e r v e d 3' t e r m i n u s of the h e p a t i t i s C virus genome. (Abstract# L0117) RT Chung and LM Kaplan. Boston, MA Hepatitis C v i r u s core p r o t e i n does n o t i n h i b i t fasi n d u c e d apoptosis i n h u m a n HepG2 cells. (Abstract# L0156) FL Dumoulin, A yon dem Bussche, J S6hne, T Sauerbruch and U Spengler. Bonn, Germany I n t e r f e r o n a l p h a u p r e g u l a t e s Fas a n d Fas l i g a n d e x p r e s s i o n a n d causes apoptosis i n leukocytes from h e a l t h y v o l u n t e e r s a n d p a t i e n t s w i t h c h r o n i c HCV infection. (Abstract# L0291) A Kaser, W Vogel and H Tilg. Innsbruck, Austria C o n t i n u o u s h u m a n h e p a t o m a cell lines stably e x p r e s s i n g the h e p a t i t i s C v i r u s s t r u c t u r a l genes effect on cell g r o w t h a n d apoptosis. (Abstract# L0527) M Reiser, I Neumann, G Lauer and W Schmiegel. Bochum, Germany

DDW Poster of Distinction: I n c r e a s e d f r e q u e n c y of the HLA-DR1 allele i n a n I r i s h anti-D p o p u l a t i o n w i t h self-limited h e p a t i t i s C v i r u s infection. (Abstract# L0041) S Barrett, E Ryan and J Crowe. Dublin, Ireland The -308 p o l y m o r p h i s m i n the p r o m o t e r r e g i o n of the TNF-a gene m a y p r e d i c t r e s p o n s e to i n t e r f e r o n - a for h e p a t i t i s C. (Abstract# G3097) JC Fang, K Redlitz and F C0minelli. Charlottesville, VA N a t u r a l course a n d liver histology of c h i l d r e n w i t h vertically t r a n s m i t t e d h e p a t i t i s C v i r u s infection. (Abstract# L0429) Y Miy0shi, Y Etani, H Tajiri, A Sawada, K Kozaiwa, K Tada, K Miki and S Okada. Osaka, Japan An e x p l o r a t i o n of the psychosocial i m p a c t of a n iatrogenic i n f e c t i o n of h e p a t i t i s C o n a p r e v i o u s l y h e a l t h y female p o p u l a t i o n . (Abstract# L0120) B Coughlan, J Sheehan, A Hickey, A Cart and J Crowe, Dublin, Ireland AASLD - - VIRAL H E P A T I T I S C: DIAGNOSIS AND MARKERS

DDW Poster of Distinction:

DDW Poster of Distinction:

Hepatitis C is associated w i t h n o n - i n s u l i n - d e p e n d e n t diabetes mellitus. (Abstract# L0495) S Pandey, AJ Sanyal, VA Luketic, RK Sterling and ML Shiffman. Richmond, VA

B a s e m e n t m e m b r a n e p e p t i d e s as m a r k e r s of l i v e r disease i n c h r o n i c h e p a t i t i s C. (Abstract# L0668) KM Walsh, A Fletcher, RNM MacSween and AJ Morris. Glasgow, United Kingdom

DDW Poster of Distinction:

DDW Poster of Distinction:

Mode of t r a n s m i s s i o n p r e d i c t s clinical outcome i n c h r o n i c h e p a t i t i s C: a n age m a t c h e d s t u d y c o m p a r i n g i n j e c t i o n d r u g u s e r s a n d t r a n s f u s i o n recipients. (Abstract# L0047) N Bayati, AL Silverman and SC Gordon. Royal Oak, MI

Risk factors associated w i t h fibrosis p r o g r e s s i o n i n chronic h e p a t i t i s C: role of alcohol c o n s u m p t i o n a n d age at infection. (Abstract# L0467) JB Nousbaum, M Richecoeur, C Vidal-Lambolais, N Lagarde, JP Leroy, M Robaszkiewicz and H Gouerou. Brest, France

Is t h e r e a difference i n l i v e r histology b e t w e e n h e p a t i t i s C a c q u i r e d t h o r u g h i n t r a v e n o u s d r u g use v e r s u s blood t r a n s f u s i o n ? (Abstract# L0152) ME Donat, MM Guindi and LJ Scully. Ottawa, Canada Effect of HIV i n f e c t i o n o n h e p a t i t i s C v i r u s a n d h e p a t i t i s G i n f e c t i o n i n h e m o p h i l i a c s a n d IV d r u g users. (Abstract# L0533) JK R0ckstr0h, R Kaiser, O L0ch, B Helm, K Schliefer, O Degen, NH Brockmeyer, R Baumgarten and the German AIDS Study Group. Bonn, Germany HCV RNA quasispecies i n p a t i e n t s w i t h n o r m a l s e r u m a l a n i n e a m i n i o t r a n s f e r a s e levels. (Abstract# L0028) J Aranda-Michel, SD Rouster and KE Sherman. Cincinnati, OH Host- a n d disease-specific factors affecting steatosis i n c h r o n i c h e p a t i t i s C. (Abstract# L0127) AJ Czaja, HA Carpenter, PJ Santrach and SB Moore. Rochester, MN

Diagnostic laparoscopy c o m p a r e d to histological, clinical a n d biochemical d a t a i n c h r o n i c HCV infection. (Abstract# L0573) P Schott, A Fayyazi, P Wietzke and G Ramadori. Goettingen, Germany

DDW Poster of Distinction: Hepatic histological changes i n p a t i e n t s p o s i t i v e for anti-HCV b u t negative by p o l y m e r a s e c h a i n r e a c t i o n for HCV-RNA: c o m p a r i s o n w i t h n o r m a l controls. (Abstract# L0011) SS Albloushi, CA Goulding, E Kay, A Grace, M Leader, MG Courtney and FE Murray. Dublin, Ireland Characteristics of p a t i e n t s positive for a n t i - h e p a t i t i s C v i r u s a n t i b o d i e s a n d n e g a t i v e for HCV-RNA b y RT-PCR. (Abstract# L0223) E Hashimoto, S Noguchi, M Taniai and N Hayashi. Tokyo, Japan

II f[

April 1998

PROGRAM OF THE ANNUAL MEETING P97

AASLD POSTER SESSION - - M O N D A Y , MAY 18, 1998 S i x m o n t h follow-up of anti-HCV a n t i b o d y positive p a t i e n t s with n o r m a l a m i n o t r a n s f e r a s e s . (Abstract# L0067) OS Brann and PJ Pockros. San Diego and La Jolla, CA

Seroprevalence of v i r a l h e p a t i t i s B a n d C: a s t u d y b a s e d o n b l o o d b o r n e p a t h o g e n exposure accidents. (Abstract# L0109) RC Cheung. Palo Alto and Stanford, CA

T a r g e t e d s c r e e n i n g of h e p a t i t i s C i n f e c t i o n by g e n e r a l p r a c t i t i o n e r s i n F r a n c e . (Abstract# L0129) P Czernichow, O Goria, JP Torre, A Libert, JP Boiteux, C Gray and R Colin. Rouen and Normandy, France

P r e v a l e n c e a n d c h a r a c t e r i s t i c s of h e p a t i t i s C i n f e c t i o n i n a n i n n e r city s u b s t a n c e abuse p o p u l a t i o n . (Abstract# L0397) DR Mallipeddi, WP Berry, MA Cerulli and L-c Liang. Brooklyn, NY

H o u s e h o l d c o n t a c t s e n h a n c e the c o m m u n i t y r i s k factors of HCV t r a n s m i s s i o n : a seroepidemiological s t u d y i n t h e same o p e n p o p u l a t i o n . (Abstract# L0389) U L0renzoni, M Rapicetta, F Chi0nne, S Lobell0, AVian and M Chiaramonte. Padua and Rome, Italy S e r u m v i r a l load a n d clincopathologic p r o g r e s s i o n of h e p a t i t i s C (lb): a s t u d y i n a h o m o g e n o u s p a t i e n t p o p u l a t i o n . (Abstract# L0166) L Fanning, E Kenny, JK Collins, M Sheehan and F Shanahan. Cork, Ireland P r e v a l e n c e of h e p a t i t i s A a n d h e p a t i t i s B i m m u n i t y i n p a t i e n t s w i t h P C R - c o n f i r m e d h e p a t i t i s C. (Abstract# L0597) F Siddiqui, M Nathani, A Kumar, M Mutchnick, R Peleman, J Kinzie and M Ehrinpreis. Detroit, MI S e q u e n t i a l s e r u m h e p a t i t i s C viral RNA levels l o n g i t u d i n a l l y assessed by b r a n c h e d DNA signal amplification. (Abstract# L0202) SC Gordon, P Dailey, AL Silverman, BA Khan, VP Kodali and JC Wilber. Royal Oak, MI and Emeryville, CA I n f l u e n c e of p r e g n a n c y o n c h r o n i c h e p a t i t i s C: p r o s p e c t i v e study. (Abstract# L0187) JA Galeras, S Coll, R Sol~, A Mur, M Vifiolas, MT Rovira, MC Vila, E Vazquez, S Delgado and M Andreu. Barcelona, Spain H e p t a t i t i s C i n f e c t i o n i n e n d stage r e n a l disease c h i l d r e n . (Abstract# L0431) Z M011e, S Rabin0witz, N Baqi, S Piecuch and D Gretch. Brooklyn, NY and Seattle, WA Biological d y n a m i c s of v i r a l load i n hemodialysis p a t i e n t s w i t h h e p a t i t i s C virus. (Abstract# L0400) P Martin, F Fabrizi, V Dixit, M Brezina, MJ Cole, S Gerosa, S Vins0n, M M0usa and G Gitnick. Los Angeles, CA Q u a n t i t a t i v e a s s e s s m e n t of HCV load i n c h r o n i c dialysis p a t i e n t s : a cross sectional survey. (Abstract# L0401) P Martin, F Fabrizi, V Dixit, M Brezina, MJ Cole, S Gerosa, S Vinson, M M0usa and G Gitnick. Los Angeles, CA A s s e s s m e n t of f a t i g u e i n c h r o n i c liver disease. (Abstract# L0473) JS Obhrai and BS Anand. Houston, TX S k i n is n o t a site of HCV r e p l i c a t i o n i n lichen p l a n u s . (Abstract# L0398) A Mangia, P Zenarola, I Cascavilla, MR Villani, V Annese, R Gentile, M Lomuto and A Andriulli. San Giovanni Rotondo, Italy Association of h e p a t i t i s C v i r u s i n c e r e b r o s p i n a l fluid w i t h c r y o g l o b u l i n e m i a a n d a s y n d r o m e of cerebritis. (Abstract# L0504) RG Perez, J Duffy, GW Petty, JJ Germer, P Rys, JB Gross, Jr and DH Persing. Rochester, MN Molecular e v i d e n c e for a nosocomial t r a n s m i s s i o n of h e a p t i t i s C virus: a case report. (Abstract# L0366) S Le Pogam, Y Bacq, R Christen, F Dubois, F Barin and A Goudeau. Tours and Villefranche-sur-mer, France

Hepatitis C: h e a l t h - r e l a t e d q u a l i t y of life, rheumatologic, v i r o l o g i c a n d histologic outcomes. (Abstract# L0704) ZM Younossi, M O'Neil, ML Kiwi, R Rosian, B Larive and L Calabrese. Cleveland, OH AASLD - - CYTOKINES AND F I B R O S I S

DDW Poster of Distinction: A c t i v a t i o n of NF-KB b y TNF-~ or IL-1 fails to s u p p r e s s F a s - m e d i a t e d apoptosis i n h u m a n h e p a t o b l a s t o m a (HepG2) cells. (Abstract# L0702) M Yoshikawa, M Toyohara, H Kawamoto, Y Matsui, J Yamao, S Kuriyama and H Fukui. Nara, Japan C o n t r i b u t i o n of proteasome-NF-KB a c t i v a t i o n p a t h w a y to i n d u c t i o n of h e p a t o c y t e d e a t h i n t h e mouse liver subjected to c o n c a n a v a l i n A. (Abstract# L0236) H Higuchi, M Adachi, S Miura and H Ishii. Tokyo, Japan Hepatic c r y o a b l a t i o n i n d u c e s NF-KB activation, c y t o k i n e p r o d u c t i o n , a n d l u n g i n j u r y i n a r a t model. (Abstract# L0137) JP Debelak, DJ Schot, TS Blackwell, JW Christman, CW Pinson, P Williams, K Washington and WC Chapman. Nashville, TN M e c h a n i s m s of s u p p r e s s i v e effect of ursodeoxycholic acid on i n t e r l e u k i n - 6 - i n d u c e d g r o u p II p h o s p h o l i p a s e A2 expression i n Hep G2 cells. (Abstract# L0258) T Ikegami, Y Matsuzaki, S Itoh, J Shoda and N Tanaka. Ibaraki, Japan The a n t i - t u m o r effect of FLT3-1igand a d m i n i s t r a t i o n o n m u r i n e liver m e t a s t a s e s is m e d i a t e d i n p a r t b y NK cells. (Abstract# L0506) JM P~ron, V Subbotin, C Haluszczak, MT Lotze and MR Shurin. Pittsburgh, PA P l a s m a a n d l y m p h of p a t i e n t s w i t h a n d w i t h o u t multiple organ failure inhibit endotoxin-induced cytokine release. (Abstract# L0364) LCJM Lemaire, T van der Poll, JJB van Lanschot, WA Buurman, SJH van Deventer and DJ G0uma. Amsterdam and Maastricht, The Netherlands C o m p l e m e n t a c t i v a t i o n i n d u c e d b y ischemiareperfusion in humans: a study in patients undergoing p a r t i a l hepatectomy. (Abstract# L0608) IH Straatsburg, MA Boermeester, GJ Wolbink, TM van Gulik, DJ Gouma, WM Frederiks and CE Hack. Amsterdam, The Netherlands E x p r e s s i o n a n d r e g u l a t i o n of CD40 o n h u m a n h e p a t o m a cell lines. (Abstract# L0245) M Holub, SM Zakeri, MF Wolschek, M Willheim and W Reinisch. Vienna, Austria S e r u m levels of soluble CD30 i n c h r o n i c viral h e p a t i t i s a n d alcoholic liver disease. (Abstract# L0526) P Ravagnan, U Lorenzoni, EA Galliani, ML Tenderini, A Popovic', A F10reani, MA Vicari0tto, C Donadel and F De Lazzari. Padua, Italy

P98 PROGRAM OF THE ANNUAL MEETING

GASTROENTEROLOGY Vol. 114~ No. 4

II

MONDAY, MAY 18, 1998 F u n g u s t h i e l a v i a m i n o r b l o c k s h e p a t i c s t e l l a t e cell p r o l i f e r a t i o n a n d i n h i b i t s e x p e r i m e n t a l h e p a t i c fibrosis in r a t s . (Abstract# L0613) H Sugawara, T Ueno, S Tamaki, M Sakamot0, T Torimura, M Kim, S Inuzuka, M Sara and K Tanikawa. Kurume, Japan S u p p r e s s i v e effects of r e t i n o i d on o x i d a t i v e s t r e s s in r a t l i v e r m i t o e h o n d r i a a n d Ito cells. (Abstract# L0486) T Omoya, I Shimizu, Y Mizobuchi, H Honda, S I t o and H Hori. Tokushima, Japan The a n t i f i b r o t i c effect of p e n t o x i f y l l i n e i n r a t s e c o n d a r y b i l i a r y f i b r o s i s is p a r a l l e l e d b y a n i n c r e a s e of h e p a t i c r e t i n y l esters. (Abstract# L0062) G Boigk, F Heinrich, HK Biesalski, JD Jia, H Herbst, EO Riecken and D Schuppan. Berlin, Hohenheim, Hamburg and Erlangen, Germany E n d o t h e l i n - 1 a c c e l e r a t e s h e p a t i c s t e l l a t e cell proliferation through the endothelin b receptor. (Abstract# L0673) XE Wang, S Watanabe, H Oide, M Hirose, T Itazu, A Miyazaki and N Sato. Tokyo, Japan S u b s t a n c e P i n d u c e d m i g r a t i o n a n d p r o l i f e r e a t i o n of c u l t u r e d r a t s t e l l a t e (Ito) cell. (Abstract# L0674) XE Wang, S Watanabe, H Oide, M Hirose, A Miyazaki and N Sato. Tokyo, Japan OK-432 e n h a n c e s t h e e x p r e s s i o n a n d a c t i v i t y of m a t r i x m e t a l l o p r o t e i n a s e - 9 i n r a t K u p f f e r cells a n d s u p p r e s s e s r a t e x p e r i m e n t a l h e p a t i c fibrosis. (Abstract# L0648) T Uen0, K Sujaku, S Tamaki, R Tsuji, M Kim, H Sugawara, M Sakam0to, T T0rimura, S Inuzuka, M Sata and K Tanikawa. Kurume, Japan Tissue i n h i b i t o r of m e t a l l o p r o t e i n a s e s - 1 , p r o c o l l a g e n I I I p e p t i d e a n d l a m i n i n as n o n - i n v a s i v e m a r k e r s of l i v e r fibrosis. (Abstract# L0599) AD Smith, PM Timms, KA Oien, PR Maxwell, RNM MacSween and BJ Danesh. Glasgow, United Kingdom The effect of a l c o h o l w i t h d r a w a l o n l i v e r t r a n s a m i n a s e s a n d t i s s u e i n h i b i t o r of m e t a l l o p r o t e i n a s e - 1 . (Abstract# L0082) S Campbell, PM Timms, PR Maxwell and BJ Danesh. Glasgow, Scotland H e p a t i c m a c r o p h a g e s a r e a s s o c i a t e d w i t h fibrosis i n h e r e d i t a r y h e m o c h r o m a t o s i s . (Abstract# L0363) KL Leicester, JK Olynyk, EM Brunt, RS Britton and BR Bacon. Nedlands, Australia and St Louis, MO I n t r a v e n o u s 13C-methacetin b r e a t h t e s t for e v a l u a t i o n of l i v e r f u n c t i o n i n c i r r h o t i c p a t i e n t s a n d h e a l t h y controls. (Abstract# L0383) T Lingenfelser, HG Wahl, W Renn, D Overkamp, J Schmidt, S Dette, W Lauchert and V Gross. Amberg and Tuebingen, Germany S i l y m a r i n d e c r e a s e s t y p e I p r o c o l l a g e n mRNA levels in r a t s w i t h s e c o n d a r y b i l i a r y c i r r h o s i s . (Abstract# L0278) JD Jia, G Boigk, M Bauer, T Strefeld, M Riihl, EO Riecken and D Schuppan. Berlin and Erlangen, Germany H e p a t i c a n t i f i b r o t i c effect of s u p e r o x i d e d i s m u t a s e i n m u r i n e s c h i s t o s o m i a s i s . (Abstract# L0210) S Guerret, S Ricard-Blum, B Dugas, E Postaire, D Hartmann, M Chevallier and P Chossegros. Lyon and Paris, France

AGA Clinical Symposium

1:00-2:30 p m

Room 41/42 Ernest N. Morial Convention Center

Sponsored by Computer and Technology Subcommittee of t h e AGA E d u c a t i o n C o m m i t t e e

Course Director: Ingram Roberts C O M P U T E R S AND T H E G A S T R O E N T E R O L O G I S T - 1998 C o m p u t i n g in t h e g a s t r o e n t e r o l o g i s t ' s office Philip Grossman. Miami, FL U p d a t e on i m a g i n g a n d p r e s e n t a t i o n t e c h n o l o g y . Benjamin Krevsky. Philadelphia, PA U p d a t e on r e s e a r c h tools for g a s t r o e n t e r o l o g y . Ingrain M. Roberts. Bridgeport, CT AGA State of the Art Lecture

2:15-3:15 p m

Ballroom A / B Ernest N. Morial Convention Center

S p o n s o r e d b y G a s t r o i n t e s t i n a l Oncology C o - s p o n s o r e d b y Clinical P r a c t i c e

Chair:

Dennis J. Ahnen

Lessons from t h e Colonic A d e n o m a . Sidney J. Winawer. New York, NY DDW

Combined Clinical Symposium

2:15-3:45 p m

Ballroom C Ernest N. Morial Convention Center

S p o n s o r e d by: AASLD/AGA/ASGE

Chairs: Neil Kaplowitz, Denis M. McCarthy INTERACTION OF ACETAMINOPHEN AND NSAIDs W I T H ALCOHOL: N A M E YOUR P O I S O N 2:15

A c e t a m i n o p h e n , alcohol a n d l i v e r i n j u r y : Pathophysiological considerations. Neil Kapl0witz. Los Angeles, CA

2:30

A c e t a m i n o p h e n , alcohol a n d l i v e r i n j u r y : Clinical p r e s e n t a t i o n a n d e x t e n t of t h e problem. William Lee. Dallas, TX

2:50

NSAIDs, a l c o h o l a n d m u c o s a l i n j u r y : pathophysiological considerations. Andrzej Tarnawski. Long Beach, CA

3:05

NSAIDs, alcohol: c l i n i c a l i n t e r a c t i o n s . Denis M. McCarthy. Albuquerque, NM

3:25

P a n e l Discussion.

April 1998

PROGRAM OF M

I

ANNUAL ME.ETING P99

MONDAY, MAY 18, 1998

AGA Clinical Symposium 2:15-3:45pm Room 61162163 Ernest N. Morial Convention Center

AGA Clinical Symposium 2:15-3:45 p m Room 99 Ernest N. Morial Convention Center

Sponsored by Intestinal Disorders Co-sponsored by Immunology, Microbiology, and Inflammatory Disorders and Growth, Development, Nutrition

Sponsored by Growth, Development, Nutrition Co-sponsored by Women in Gastroenterology Committee

Chair:

ADVANCES IN OBESITY

Stefano Guandalini

CELIAC DISEASE Introduction. Stephano Guadalini. Chicago, IL Identifying the genetic basis for celiac disease. Francoise Clerget-Darpoux. Bordeaux, France Autoantibodies, autoantigens and autoimmunity in celiac disease. Are we there yet? Markku Maki. Tampere, Finland The clinical h e t e r o g e n e i t y of celiac disease. Anne Ferguson. Edinburgh, Scotland

Chair:

Samuel Klein

Regulation of food intake: molecular mechanisms. L. Arthur Campfield. Nutley, NJ Epidemiology of obesity. Katherin M. Flegal. Baltimore, MD Pathophysiology a n d clinical m a n a g e m e n t of obesity. Samuel Klein. St. Louis, MO AGA Clinical Symposium 2:15-3:45 p m Hall C Ernest N. Morial Convention Center

Sponsored by Pancreatic Disorders Co-sponsored by Biliary Disorders

AGA Clinical Symposum 2:15-3:45 p m Room 85/86 Ernest N. Morial Convention Center

Chairs: Eugene P. DiMagno, Peter A. Banks

Sponsored by Growth, Development, Nutrition

NEW PANCREATIC IMAGING MODALITIES

Chair:

Rosemarie L. Fisher

CURRENT ISSUES IN TPN Use of t r a c e elements in p a r e n t e r a l nutrition. William D. Heizer. Chapel Hill, NC A p p r o p r i a t e use of lipid solutions in TPN. Stephen D. Phinney. Davis, CA

Endoscopic u l t r a s o n o g r a p h y of the pancreas. Michael V. Sivak, Jr. Cleveland, OH MR cholangiopancreatography. Joseph Ferrucci. Boston, MA Pancreatoscopy. Richard A. Kozarek. Seattle, Washington

TPN-related liver disease. Rosemarie L. Fisher. New Haven, CT

AGA Research Symposium 2:15-3:45 p m Room 80/81 Ernest N. Morial Convention Center

A critical look at growth factors a n d i m m u n o m o d u l a t o r s in p a r e n t e r a l nutrition. Timothy O. Lipman. Washington, DC

Sponsored by Immunology, Microbiology, and Inflammatory Disorders Co-Sponsored by PhD, MD/PhD, DVM Task Force Chairs: Colin Burrows, Robert Washabau CURRENT TOPICS IN COMPARATIVE GASTROENTEROLOGY: VIRAL HEPATITIS AND HEPATIC CARCINOGENESIS

2:15

Animal models of h e p a t i t i s B virus infection. John M. Cullen. Raleigh, NC

2:50

Woodchuck h e p a t i t i s virus infection: role in hepato-carcinogenesis. Bud C. Tennent. Ithaca, NY

3:25

Panel discussion

P 1 0 0 P R O G R A M OF THE ANNUAL M E E T I N G

I1

G A S T R O E N T E R O L O G Y Vol, 114~ No. 4

MONDAY, MAY 18, 1998

AGA Topic Forum

2:15-3:45 p m

3:00

Does m o r e B a r r e t t ' s r e a l l y m e a n m o r e c a n c e r ? C o m p a r i s o n of i n c i d e n c e r a t e s of a d e n o c a r c i n o m a i n p r o s p e c t i v e l y followed p a t i e n t cohorts w i t h s h o r t a n d l o n g s e g m e n t s of B a r r e t t ' s esophagus. (Abstract# G2783) T Schnell, SJ Sontag, G Chejfec, C Kurucar, S O'Connell, G Levine, J Karpf, L Brand and A Ulasevich. Hines and Maywood, IL

3:15

A d e t a i l e d analysis of t h e p a t t e r n of n e o s q u a m o u s e p i t h e l i u m following endoscopic a r g o n b e a m p l a s m a c o a g u l a t i o n of B a r r e t t ' s esophagus. (Abstract# G0245) SEA Attwood, JP Byrne and GR Armstrong. Manchester, United Kingdom

3:30

"Squamous islands" i n B a r r e t t ' s esophagus: b i o m a r k e r studies suggest c o n t i n u e d i n c r e a s e d c a n c e r risk. (Abstract# G0527) H Garewal, L Ramsey, P Sharma, R Fass, T Morales and R Sampliner. Tucson, AZ

Room 13 / 15 / 17 Ernest N. Morial Convention Center

Chairs: Daniel H. Present, Herbert Lochs INNOVATIONS IN MEDICAL THERAPY FOR IBD 2:15

P o s t o p e r a t i v e p r o p h y l a x i s w i t h 6-MP, 5-ASA or placebo i n C r o h n ' s disease: a two year m u l t i c e n t e r trial. (Abstract# G4141) B Korelitz, S Hanauer, P Rutgeerts, D Present and M Peppercorn. Chicago, IL

2:30

6 - m e r c a p t o p u r i n e + p r e d n i s o n e t h e r a p y for n e w l y d i a g n o s e d p e d i a t r i c C r o h n ' s disease: a prospective, m u l t i c e n t e r , placebo-controlled clinical trial. (Abstract# G4227) J Markowitz, K Grancher, F Mandel, F Daum and the 6MP Collaborative Group. Manhasset, NY

2:45

B i s m u t h s u b s a l i c y l a t e t a b l e t s for c h r o n i c a n t i b i o t i c - r e s i s t a n t pouchitis. (Abstract# G4506) W J Tremaine, WJ Sandborn and ML Kenan. Rochester, MN

3:00

3:15

3:30

I n t r a v e n o u s c y c l o s p o r i n e m o n o t h e r a p y versus intravenous methylprednisolone monotherapy i n severe u l c e r a t i v e colitis: a r a n d o m i z e d , d o u b l e - b l i n d c o n t r o l l e d trial. (Abstract# G3948) G D'Haens, L Lemmens, M Hiele, L Vandeputte, F Nevens, M Peeters, S Vermeire, F Baert, K Geboes and P Rutgeerts. Leuven, Belgium

AGA Topic Forum

2:15-3:45 p m

Chairs: Ira S. Goldman, Alan F. Cutler COMMON CLINICAL DILEMMAS - - AN EVIDENCEBASED APPROACH 2:15

R a n d o m i s e d t r i a l of m y c o p h e n o l a t e mofetil versus a z a t h i o p r i n e for t r e a t m e n t of c h r o n i c active C r o h n ' s disease. (Abstract# G4298) MF Neurath, R Wanitschke, M Peters, F Krummenauer, K-H Meyer zum Biischenfelde and JF Schlaak. Mainz, Germany

Bile acid m a l a b s o r p t i o n - r e l a t e d d i a r r h e a : common, easily d i a g n o s e d a n d t r e a t a b l e . (Abstract# G0170) M Smith, P Cherian, GS Raju, S Mah0n and KD Bardhan. Rotherham, United Kingdom

2:30

M a i n t e n a n c e t r e a t m e n t of c h r o n i c pouchitis: a r a n d o m i s e d placebo-controlled, double-blind trial with a new probiotic preparation. (Abstract# G4037) P Gi0nchetti, F Rizzello, A Venturi, D Matteuzzi, M R0ssi, S Peruzzo, G P0ggi01i, G Bazzocchi and M Campieri. Bologna, Italy

A six-week r a n d o m i z e d c o n t r o l l e d t r i a l of olestra or r e g u l a r s n a c k foods: c o m p a r i s o n of g a s t r o i n t e s t i n a l s y m p t o m s i n a large p o p u l a t i o n . (Abstract# G0158) RS Sandler, NL Zorich, TG Filloon, HB Wiseman, DJ Lietz, MH Brock and RK Miday. Chapel Hill, NC and Cincinnati, OH

2:45

The i m p a c t of o v e r - t h e - c o u n t e r h i s t a m i n e - 2 a n t a g o n i s t s : great e x p e c t a t i o n s unfulfilled. (Abstract# G0166) MJ Shaw, RL Kane, AM Fendrick, SA Adlis and NJ Talley. Minneapolis, MN; Ann Arbor, MI and Penrith, Australia

3:00

A p p r o p r i a t e n e s s of u p p e r g a s t r o i n t e s t i n a l endoscopy: r a n d o m i z e d t r i a l of a l g o r i t h m b a s e d versus free clinical decision. (Abstract# G0055) F Froehlich, JP Vader, B Burnand, C Schneider, V Wietlisbach, S Realini, K Gyr, G Stalder, I Pache, C Beglinger and JJ Gonvers. Lausanne and Basel, Switzerland Do explicit a p p r o p r i a t e n e s s c r i t e r i a e n h a n c e t h e diagnostic yield of colonoscopy? A prospective m u l t i c e n t e r study. (Abstract# G0066) JJ Gonvers, C Schneider, B Miilhaupt, C Repond, JP Rey, J Thorens, B Burnand, JP Vader, I Pache, M Fried and F Froehlich. Lausanne and Ziirich, Switzerland

AGA Topic Forum

2:15-3:45 p m

Room 82/83 Ernest N. Morial Convention Center

Chairs: Richard E. Sampliner, Brian J. Reid BARRETT'S E S O P H A G U S 2:15

2:30

2:45

Room 90 / 91 / 92 Ernest N. Morial Convention Center

The role of pl6INK4A p r o m o t e r hypermethylation during neoplastic progression i n B a r r e t t ' s esophagus. (Abstract# G2577) B Klump, CJ Hsieh, K Holzmann, M Gregor and R P0rschen. Tuebingen, Germany

cagA ÷H. pylori c o l o n i z a t i o n m a y p r e v e n t B a r r e t t ' s esophagus. (Abstract# G1293) MF Vaezi, JJ Vicari, GW Falk, RM Peek, JR Goldblum, TW Rice, GI Perez-Perex, JB O'Connor, MJ Blaser and JE Richter. Cleveland, OH and Nashville, TN Prospective evaluation of the assecition of gastric H. pyloriinfection with Barrett's dysplasia and Barrett's adenocarcinoma. (Abstract# G2908) AP Westen, AS Badr, PT Krmp0tich, M Topalovski, R Cherian and A Dixon. Kansas City, MO and Kansas City, KS

3:15

3:30

History a n d p h y s i c a l e x a m i n a t i o n identifies p a t i e n t s at low r i s k of r e c u r r e n t h e m o r r h a g e from either u p p e r or lower g a s t r o i n t e s t i n a l causes. I n t e r i m a n a l y s i s of a p r o s p e c t i v e v a l i d a t i o n study. (Abstract# G0175) J Spears, R Fogel and T Ben-Menachem. Detroit, MI

A p r i l 1998

P R O G R A M O F T H E A N N U A L M E E T I N G P101

tl

MONDAY, MAY 18, 1998

AASLD Research Forum

2:15-3:45 p m

3:00

E s t r o g e n r e c e p t o r s are e x p r e s s e d i n r a t cholangiocytes a n d u p r e g u l a t e d after bile d u c t ligation. T h e i r i n h i b i t i o n w i t h chronic tamoxifen t r e a t m e n t m a r k e d l y decreases s e c r e t i n - i n d u c e d d u c t a l bile secretion. (Abstract# L0018) D Alvaro, G Alpini, S Glaser, E Papa, P Onori, A Franchitto, A Gigliozzi, A Caligiuri, G LeSage and E Gaudio. Rome and L'Aquila, Italy; Temple, TX

3:15

Glutathione depletion in h u m a n cholangiocytes is associated w i t h i n c r e a s e d Bcl-2 d e g r a d a t i o n a n d e n h a n c e d apoptosis. (Abstract# L0086) A Celli, FG Que, GJ Gores and NF LaRuss0. Rochester, MN

3:30

P r o i n f l a m m a t o r y cytokines i n d u c e i n j u r y to a bile duct cell l i n e in vitro. (Abstract# L0670) JY Wang and HL Sharp. Minneapolis, MN

Room 93/94 Ernest N. Morial Convention Center

Chairs: Norman D. Grace, Norah A. Terrault CLINICAL H E P A T O L O G Y 2:15

2:30

2:45

3:00

3:15

3:30

Clinical f e a t u r e s a n d i n d i c a t o r s of prognosis of h e r p e s simplex a n d varicella zoster h e p a t i t i s i n n o n - p r e g n a n t p a t i e n t s . (Abstract# L0030) AS Arora and PC de Gr0en. Rochester, MN H u m a n h e r p e s v i r u s 6 from p a t i e n t s with NANBNC f u l m i n a n t h e p a t i t i s i n J a p a n . (Abstract# L0268) K Ishikawa, K Hasegawa, S Noguchi, A Iizuka, T Shizuma, N Torii, T Naritomi, E Hashimoto, K Yamauchi, Y Kato, N Sakayori, M Kobayashi and N Hayashi. Tokyo, Japan Effect of t e r l i p r e s s i n e (Glypressine®) o n h e p a t o r e n a l s y n d r o m e i n cirrhotic patients: r e s u l t s of a pilot study. (Abstract# L0063) P B0nnard, B Bernard, C Halhni, P Mathurin, R Demontis, V di Martino, E Henry-Biabaud, A Mofredj, T Poynard and JF Cadranel. Crefl and Paris, France C h a r a c t e r i z a t i o n of gastric mucosal damage i n d u c e d b y a s p i r i n i n p o r t a l h y p e r t e n s i v e rats. (Abstract# L0080) S Calatayud, MC Ramirez, MJ Sanz, JM Piqu6, J Bosch and JV Esplugues. Valencia, Spain I n c r e a s e of a n d r o s t e n e d i o n e a n d estradiol i n c i r r h o t i c m e n t r e a t e d by t r a n s j u g u l a r intrahepatic portosystemic stent-shunt. (Abstract# L0466) W N01te, C SchincUer, W Wuttke, H Hartmann, M Hiifner and G Ramadori. Goettingen, Germany I m p a i r e d n i t r i c oxide release i n cirrhotic r a t liver. (Abstract# L0215) F Haddad, M Toruner, V Shah, TK Gupta and RJ Groszmann. New Haven, CT

Biliary Disorders AGA Research Forum

2:15-3:45 p m

Chairs: Jose Behar, Gerald P. van Berge-Henegouwen GALLBLADDER AND S P H I N C T E R OF ODDI MOTILITY 2:15

Mechanisms of p r e g n a n c y - i n d u c e d g a l l b l a d d e r hypomotflity i n g u i n e a pigs. (Abstract# G2248) ZL Xiao, Q Chen, P Biancani and J Behar. Providence, RI

2:30

Effect of e x p e r i m e n t a l a c a l c u l o u s cholecystitis o n g a l l b l a d d e r smooth m u s c l e contractility. (Abstract# G2192) HP Parkman, L Bogar, L Bartula, AP Pagano, RM Thomas and SI Myers. Philadelphia, PA

2:45

Effect of i n s u l i n on c h o l e c y s t o k i n i n - s t i m u l a t e d g a l l b l a d d e r m o t i l i t y i n h u m a n s . (Abstract# G2125) HAJ Gielkens, WF Lain, JA van O0stayen, M Fr61ich, M Coenraad, CBHW lamers and AAM Masclee. Leiden, The Netherlands

3:00

I n d u c i b l e n i t r i c oxide s y n t h a s e is the p r i n c i p a l isoform expressed i n h u m a n gallbladder. (Abstract# G2145) AP Keaveny, GD Offner and NH Afdhal. Boston, MA

3:15

M o r p h o - f u n c t i o n a l e v i d e n c e for t a c h y k i n i n s as major non-cholinergic excitatory transmitters i n the g u i n e a p i g c o m m o n bile duct. (Abstract# G2U5) R DeGiorgio, R Patacchini, L Barthb, G Barbara, V ViUani, V StangheUini, CA Maggi and R C0rinaldesi. Florence and Bologna, Italy; Pecs, Hungary

3:30

Effect of s e c r e t i n o n s p h i n c t e r of Oddi m o t i l i t y i n h u m a n s . (Abstract# G2258) BM Yoo, JH Kim, JM Kim, YJ Shin, KB Hahm and SW Cho. Suwon, Korea

AASLD Research Forum

2:15-3:45 p m

Room 95/96 Ernest N. Morial Convention Center

Chairs: Gene D. LeSage, Steven A. Weinman HEPATOCYTE AND CHOLANGIOCYTE BIOLOGY 2:15

2:30

2:45

H e p a t o c y t e cytoskeletal k e r a t i n b i n d i n g to 143-3 p r o t e i n s a n d 14-3-3 r e g u l a t i o n of p h o s p h o k e r a t i n o r g a n i z a t i o n d u r i n g mitosis. (Abstract# L0340) N-O Ku, J Liao and MB Omary. Palo Alto, CA R e g u l a t i o n of the gene for a m p h o t r o p i c r e t r o v i r u s r e c e p t o r i n r a t liver cells b y h e p a t o c y t e g r o w t h factor a n d t r i i o d o t h y r o n i n e . (Abstract# L0424) H Minami, K Tada, Y Oka, H Iuchi, N H0riike and M Onji. Ehime, Japan A c t i v a t i o n of different i o n c h a n n e l s i n cholangiocytes a n d hepatocytes: a possible e x p l a n a t i o n for different susceptibility to oxidative stress? (Abstract# L0567) T Schlenker, L Schwake, S Lauterbach, V Ehemann, JG Fitz and W Stremmel. Heidelberg, Germany and Denver, CO

Room 20 Ernest N. Morial Convention Center

P 1 0 2 P R O G R A M OF T H E A N N U A L M E E T I N G

II

G A S T R O E N T E R O L O G Y Vol. 114~ No. 4

MONDAY, MAY 18, 1998 2:45

C h a r a c t e r i z a t i o n of t h e pANCA core epitope i n the h i s t o n e H1 C t e r m i n u s . (Abstract# G3905) O Cohavy, AB Tayebali, PK Phu, MP Eggena, MH Parseghian, BA Hamkalo, S Targan and J Braun. Los Angeles and Irvine, CA

3:00

P l a t e l e t - d e r i v e d g r o w t h factor i n d u c e s t y r o s i n e p h o s p h o r y l a t i o n of L-type Ca 2÷ c h a n n e l s via pp60 c'src i n r a b b i t colonic m u s c u l a r i s mucosae. (Abstract# G3166) X-Q Hu, N Singh and HI Akbarali. Boston, MA

C D l d expression o n i n t e s t i n a l e p i t h e l i a l cells is decreased i n i n f l a m m a t o r y b o w e l disease. (Abstract# G4452) K Somnay-Wadgaonkar, A Nusrat, W Canchis, SP Colgan andRS Blumberg. Boston, MA and Atlanta, GA

3:15

C u r r e n t levels a n d ~ - s u b u n i t e x p r e s s i o n of Ca2+-activated K ÷ c h a n n e l s i n colonic c i r c u l a r s m o o t h m u s c l e cells from p a t i e n t s with u l c e r a t i v e colitis. (Abstract# G3275) G Lu, Y Liu, MG Berger, NJ Rusch, H-G Knaus, GL Telford and SK Sarna. Milwaukee, WI and Innsbruck, Austria

ICAM-1 a n t i s e n s e d i s r u p t s i n t e s t i n a l fibroblast-T cell i n t e r a c t i o n : i m p l i c a t i o n s for m o d u l a t i o n of i n t e s t i n a l i n f l a m m a t i o n . (Abstract# G4284) A Musso, TF C0ndon, CF Bennett, AD Levine and C Fiocchi. Cleveland, OH and Carlsbad, CA

3:30

Altered expression of Fas l i g a n d b y colonic e p i t h e l i u m i n C r o h n ' s disease a n d u l c e r a t i v e colitis. (Abstract# G3809) MW Bennett, J O'C0nnell, GC O'Sullivan, JK Collins and F Shanahan. Cork, Ireland

D o s e - d e p e n d e n t effects of interleukin-11 on c o n t r a c t i l e p a r a m e t e r s i n r a b b i t TNBS colitis. (Abstract# G3063) I Depoortere, G Van Assche, JC Keith and TL Peeters. Leuven, Belgium and Andover, MA

Motility and Nerve-Gut Interactions AGA Research Forum

Motility and Nerve-Gut Interactions AGA Research Forum

2:15-3:45 p m

Room 22 Ernest N. Morial Convention Center

Chairs: Stephen M. Collins, Yvette Tachd ACUTE E F F E C T S OF INFLAMMATORY MEDIATORS AND GROWTH FACTORS 2:15

2:30

2:45

3:00

3:15

3:30

2:15-3:45 p m

I n t e r l e u k i n - l ~ a n d i n t e r l e u k i n - 6 excite n e u r o n s a n d s u p p r e s s e x c i t a t o r y cholinergic n e u r o t r a n s m i s s i o n i n the m y e n t e r i c plexus of g u i n e a p i g small i n t e s t i n e . (Abstract# G3197) A Kelles, I Demerits, P Vanden Berghe, J Tack and J Janssens. Leuven, Belgium

2:15

Prior infection with an entericpathogenic nematode induces long-lasting alterations in e n t e r i c n e u r o m u s c u l a r f u n c t i o n i n ferrets. (Abstract# G3506) K Venk0va, JM Palmer and B GreenwoodVan Meerveld. Oklahoma, OK and Omaha, NE

Swallow-induced a b n o r m a l l y p r o l o n g e d lower esophageal s p h i n c t e r relaxations. (Abstract# G3442) D Sifrim, RH Holloway, T Missotten, A Zelter and J Janssens. Leuven, Belgium and Adelaide, Australia

2:30

I n v o l v e m e n t of n i t r i c oxide i n t r a n s i e n t lower esophageal s p h i n c t e r r e l a x a t i o n s a n d esophageal p r i m a r y peristalsis i n h e a l t h y volunteers. (Abstract# G3155) DP Hirsch, RH H011oway, GNJ Tytgat and GE Boeckxstaens. Amsterdam, The Netherlands and Adelaide, Australia

2:45

P h a r m a c o l o g i c a l effects of i n t r a s p h i n c t e r i c b o t u l i n u m t o x i n o n the lower esophageal s p h i n c t e r r e s p o n s e to CCK, a t r o p i n e a n d e d r o p h o n i u m i n achalasia. (Abstract# G3009) R Bulat, Y Chen, B Fachnie, G Tougas, MD Crowell, AN Kalloo and PJ Pasricha. Hamilton, Canada; Baltimore, MD and Galveston, TX

3:00

Delayed liquid a n d solid gastric e m p t y i n g i n gene k n o c k o u t mice l a c k i n g n e u r o n a l n i t r i c oxide synthase. (Abstract# G3285) H Mashimo, AP Kjellin, EJ Ashegh and RK Goyal. West Roxbury and Boston, MA

3:15

Effect of p y l o r o m y o t o m y o n p y l o r i c activity a n d gastric e m p t y i n g of n u t r i e n t liquid. (Abstract# G3466) WM Sun, S Doran, KL Jones, G Davidson, M Horowitz and J Dent. Adelaide, Australia

3:30

I n t r i n s i c s e r o t o n e r g i c n e u r o n s of t h e g u i n e a p i g s p h i n c t e r of Oddi. (Abstract# G3154) K Hillsley and GM Mawe. Burlington, VT

Chairs: John Dent, Raj K. Goyal SPHINCTERS

Differential a c t i v a t i o n of p h o s p h o i n o s i t i d e 3k i n a s e b y e n d o t h e l i n a n d c e r a m i d e i n colonic s m o o t h m u s c l e cells. (Abstract# G3463) X Su, U Aronsson and KN Bitar. Ann Arbor, MI

Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum

2:15-3:45 p m

Room 24 Ernest N. Morial Convention Center

Chairs: James K. Roche, Fergus Shanahan H U M A N IBD P A T H O G E N E S I S 2:15

2:30

Room 28 Ernest N. Morial Convention Center

Catalase a n d alpha-enolase: two novel granulocyte autoantigens in inflammatory bowel diseases. (Abstract# G4387) C R0ozendaal, MH Zhao, G H0rst, CM Lockwood, JH Kleibeuker, PC Limburg, GF Nelis and CGM Kallenberg. Gr0ningen and Zw011e, The Netherlands and Cambridge, United Kingdom Co-expression of h u m a n tropomyosin isoform 5 a n d a novel colon epithelial protein i n the colon epithelium a n d extracolonic organs commonly involved i n ulcerative colitis. (Abstract# G4228) M Marks, S Borra, K Nandiwada and KM Das. New Brunswick, NJ

A p r i l 1998

P R O G R A M O F T H E A N N U A L M E E T I N G P103

MONDAY, MAY 18, 1998 Pancreatic Disorders AGA Research Forum

2:15-3:45 p m

3:00

Does '~near p a t i e n t " H. pyloritesting i n p r i m a r y care r e d u c e r e f e r r a l for endoscopy? Results from a r a n d o m i z e d trial. (Abstract# G0451) A Duggan, C Elli0tt, RPH Logan, C Hawkey and RFA Logan. Nottingham, United Kingdom

3:15

A p r o s p e c t i v e r a n d o m i s e d t r a i l of a "test a n d treat" policy versus g a s t r o s c o p y i n y o u n g H. pylori-positive dyspeptic p a t i e n t s . (Abstract# G0604) A Heaney, JSA Collins, RGP Watson, RJ McFarland, KB Bamford and TCK Tham. Belfast and Dindonald, Northern Ireland

3:30

Long t e r m follow-up of p a t i e n t s with n o n - u l c e r d y s p e p s i a after Helivobacterpylori eradication. A randomized double-blind placebo-controlled trial. (Abstract# G1249) NJ TaUey, J Janssens, K Lauritsen, I R~cz, E B011ing-Sternevald, N Havu, O Junghard and G Sj6gren. Penrith, Australia

Room 33/35 Ernest N. Morial Convention Center

Chairs: David C. Whitcomb, Stephen Pandol E T H A N O L AND T H E PANCREAS 2:15

Ethanol a n d fatty acid ethyl esters induce activation of transcription factors NF-r~Ba n d API i n pancreatic acinar cells. (Abstract# G1888) AS Gukovskaya, I Guk0vsky, DT Kira, H Lain, S Gukovsky and SJ Pandol. Los Angeles, CA

2:30

F a s t i n g p l a s m a level of islet amyloid p o l y p e p t i d e is i n c r e a s e d i n c h r o n i c alcoholic p a n c r e a t i t i s . (Abstract# G1959) E Malecka-Panas, A Gasiorowska, A Kozlowska, D Orszulak-Michalak and J Drzewoski. Lodz, Poland

2:45

Effect of e t h a n o l o n gene expression of MP/PSTI i n r a t p a n c r e a s . (Abstract# G1951) HS Li, J Ra0, BS Thompson, XY Dang, PG Wood, PK Eagon and DC Whitc0mb. Pittsburgh, PA

3:00

Risk factors for d e v e l o p i n g c h r o n i c p a n c r e a t i t i s after a first a t t a c k of acute alcoholic p a n c r e a t i t i s . (Abstract# G1939) PG Lankisch, C Assmus, D Pflichthofer, P Maisonneuve and AB Lowenfels. Lueneburg, Germany; Milan, Italy and Valhalla, NY

3:15

Yield of genetic t e s t i n g i n p a n c r e a t i c disease as we k n o w it i n 1997. (Abstract# G1819) CP Choudari, T Stewart, D Crabb, EL Fogel, S Sherman and GL Lehman. Indianapolis, IN

3:30

D u o d e n a l e t h a n o l i n f u s i o n i n conscious r a t s alters exocrine p a n c r e a t i c r e s p o n s e to n e u r o h o r m o n a l stimuli. (Abstract# G1836) X Dang, PG Wood, MRA Pedr0s0, PK Eagon and DC Whitcomb. Pittsburgh, PA

Hormones, Transmitters, Growth Factors and Their Receptors AGA Research Forum

2:15-3:45 p m

Chairs: Timothy C. Wang, Joseph R. Pisegna MOLECULAR BIOLOGY 2:15

A c t i v a t i o n of h u m a n h i s t i d i n e decarboxylase gene t r a n s c r i p t i o n b y g a s t r i n is m e d i a t e d b y two d i s t i n c t n u c l e a r factors. (Abstract# G4800) R Raychowdhury, Z Zhang and TC Wang. Boston, MA

2:30

The r ~ E r k k i n a s e signal t r a n s d u c t i o n p a t h w a y s t i m u l a t e s the g a s t r i n p r o m o t e r t h r o u g h t h e GC-rich gERE element. (Abstract# G4763) JL Merchant, SA Tarld, M Du, M Ford and A Todisco. Ann Arbor, MI Cell-specific expression of t h e gastric i n h i b i t o r y polypeptide gene f u n c t i o n s t h r o u g h a GATA m o t i f i n a m o u s e n e u r o e n d o c r i n e t u m o r cell line. (Abstract# G4715) LI Jepeal, MO Boylan and MM Wolfe. Boston, MA

2:45 Esophageal, Gastric, and Duodenal Disorders AGA Research Forum

2:15-3:45 p m

Room 5 8 / 5 9 / 6 0 Ernest N. Morial Convention Center 3:00

Chairs: Philip S. Schoenfeld, Sander Van Zanten DYSPEPSIA AND HELICOBACTER PYLORI 2:15

2:30

2:45

What p r o p o r t i o n of dyspepsia i n the g e n e r a l p o p u l a t i o n is a t t r i b u t a b l e to Helicobacter pylorfi. (Abstract# G0946) P Moayyedi, D Braunh01tz, S Duffet, S Mason, IDG Richards, AC Dowell and ATR Ax0n. Leeds, United Kingdom The p a t h o g e n i c role of Helicobaeterpylori i n f e c t i o n i n n o n u l c e r dyspepsia - a crosss e c t i o n a l e v a l u a t i o n of 6143 active employees i n a large company. (Abstract# Gl147) D Schilling, P Schauwecker, F Eberle, J Ott, A Zober and JF Riemann. Ludwigshafen, Germany

H. p y l o ~ ' ~ s t and treat" or prompt endoscopy for dyspeptic patients i n p r i m a r y care. A randomized controlled trial of two management strategies one-year follow-up. (Abstract# G0803) AT Lassen, FM Pedersen, P Bytzer and OB Schaffalitzky de Muckadell. Odense, Denmark

Room 88 Ernest N. Morial Convention Center

3:15

3:30

The t r a n s c r i p t i o n a l c o a c t i v a t o r p300 f u n c t i o n a l l y associates w i t h the basic helix loop helix p r o t e i n , beta2 in vivo to activate t r a n s c r i p t i o n of the s e c r e t i n gene. (Abstract# G4776) H Mutoh and AB Leiter. Boston, MA S p l a n d CREB m e d i a t e g a s t r i n - d e p e n d e n t r e g u l a t i o n of c h r o m o g r a n i n A p r o m o t e r activity. (Abstract# G4706) M H6cker, R Raych0whury, H Wu, DT O'Connor, EO Riecken, S Rosewicz and TC Wang. Berlin, Germany and Boston, MA Co-ordinated expression of h i s t i d i n e decarboxylase a n d v e s i c u l a r m o n o a m i n e t r a n s p o r t e r type 2 i n d u c e d b y r a i s e d i n t r a c e l l u l a r calcium. (Abstract# G4865) F Watson, DG Deavall, JA Macro and R Dimaline. Liverpool, United Kingdom

P104 P R O G R A M O F T H E A N N U A L M E E T I N G

G A S T R O E N T E R O L O G Y Vol. 114~ No. 4

MONDAY, MAY 18, 1998 Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum

2:15-3:45 p m

Room 89 Ernest N. Morial Convention Center

Chairs: Richard S. Blumberg, Ellen C: Ebert MUCOSAL IMMUNOLOGY I 2:15

2:30

2:45

3:00

3:15

3:30

Efficient h o m i n g of i n t r a e p i t h e l i a l - d e r i v e d l y m p h o c y t e s b a c k to t h e i n t e r c e l l u l a r spaces of m o d e l p o l a r i z e d i n t e s t i n a l epithelia. (Abstract# G4436) T Shibahara, SK Shaw, A Herman0wski-V0satka, A Gewirtz, BA McCormick, A Nusrat, CA Park0s and JL Madara. Boston, MA and Atlanta, GA B i l i a r y g l y c o p r o t e i n (CD66a) f u n c t i o n s as a n i n h i b i t o r y coreceptor for a c t i v a t i o n of h u m a n i n t e s t i n a l i n t r a e p i t h e l i a l lymphocytes. (Abstract# G4271) V Morales, A Christ, S Watt, G Russell, AK Bahn, A Mizoguchi, G Freeman and RS Blumberg. Boston, MA and Oxford, United Kingdom Mucosal i m m u n e d e p e n d e n c y o n CD28 c o s t i m u l a t i o n . (Abstract# G3841) D Boone, T Dassop0ul0s, J Lodolce, S Chai, S Trettin and A Ma. Chicago, IL The f o r m a t i o n of a novel class Ib:gpl80 comples o n the surface of i n t e s t i n a l epithelial cells t r i g g e r s a s i g n a l i n g cascade r e s u l t i n g i n the a c t i v a t i o n of CD8+ s u p p r e s s o r T cells. (Abstract# G3875) NA Campbell, S Balk, R Blumberg and L Mayer. New York, NY and Boston, MA Antigen-specific a n d n o t bystander m e c h a n i s m s i n d u c e T cell a c t i v a t i o n i n the i n t e s t i n e . (Abstract# G4448) SM Sitterding, H Lee, S Biafora, SD Hurst and TA Barrett. Chicago, IL Fas m e d i a t e d p r o g r a m m e d cell d e a t h of m u r i n e l a m i n a p r o p r i a lymphocytes. (Abstract# G3935) T Dassopoulos, D Boone, J Lod01ce, S Chai, S Trettin and A Ma. Chicago, IL

AGA Clinical Symposium

3:00-5:00 p m

Room 41/42 Ernest N. Morial Convention Center

AGA State of the Art Lecture

4:00-5:00 p m

Room 22 Ernest N. Morial Convention Center

Sponsored by Hormones, Transmitters, Growth Factors and their Receptors -- Co-sponsored by Pancreatic Disorders and Motility and Nerve-Gut Interactions Chair:

John H. Walsh

P e p t i d e r e c e p t o r signaling. Enrique Rozengurt. Los Angeles, CA AGA State of the Art Lecture

4:00-5:00 p m

Room 64 / 65 / 66 Ernest N. Morial Convention Center

Sponsored by Immunology, Microbiology, and Inflammatory Disorders Co-sponsored by Esophageal, Gastric, and Duodenal Disorders Chair:

Mae F. Go

Antibiotic r e s i s t a n c e i n Helicobacterp.vlori. Francois Megraud. Bordeaux, France. AGA State of the Art Lecture

4:00-5:00 p m

Room 99 Ernest N. Morial Convention Center

Sponsored by Intestinal Disorders Co-sponsored by Gastrointestinal Oncology Cell adhesion, m i g r a t i o n , a n d signalling: crosstalk i n v o l v i n g c a d h e r i n , catenins, a n d APC p r o t e i n . W. James Nelson. Stanford, CA AGA State of the Art Lecture

4:00-5:00 p m

Hall C Ernest N. Morial Convention Center

Sponsored b y Clinical P r a c t i c e

• Chair:

Ira M. Jacobson

New t r e a t m e n t s of viral h e p a t i t i s . Eugene Schiff. Miami, FL

Co-sponsored b y E d u c a t i o n Committee, Manpower and T r a i n i n g Committee, T r a i n e e Committee

DDW C o m b i n e d C l i n i c a l S y m p o s i u m 4:00-5:30 p m Room 58 /59 / 60 Ernest N. Morial Convention Center

Chair: Andrea Reid Speaker: Albert J. Zdenek, Jr. Flemington, N J

Sponsored b y AASLD/AGA

S E C U R I N G YOUR FINANCIAL F U T U R E • •

The Basic Rules of Finance. An example of the "pile of money" (wealth) one needs in life to be independent. • How income taxes determine how much gets to be added to one's "pile of money" or taken from it. • Structuring student debt correctly to enable a physician to get independence faster and to have the choice to work fewer years in life. • Understanding and negotiating a financially sound employment contract. • A sample of an employment contract will enable the attendees to design a more financially advantageous employment agreement of their own. • How the attendees can calculate their own numbers to restructure debt.

Chairs: T. Jake Liang, Lee M. Kaplan MOLECULAR P A T H O G E N E S I S OF VIRAL HEPATITIS 4:00

Molecular virology of H e p a t i t i s C virus. Stanley Lemon. Galveston, TX

4:25

I m m u n o p a t h o g e n e s i s of h e p a t i t i s B and C: clinical a n d t h e r a p e u t i c i m p l i c a t i o n s . Barbara Rehermann. Bethesda, MD

4:50

5:15

A n t i v i r a l s for h e p a t i t i s C virus: challenges and prospects. Berwyn Clarke. Beckenham, England Questions a n d answers.

April 1998

PROGRAM OF THE ANNUAL MEETING P105

MONDAY, MAY 18, 1998 DDW C o m b i n e d C l i n i c a l S y m p o s i u m 4:00-5:30 p m Ballroom C Ernest N. Morial Convention Center

AGA Research Symposium

S p o n s o r e d by: SSAT/AGA/ASGE

Chairs: James M. Becker, Mark A. Peppercorn

Sponsored by Immunology, Microbiology, and Inflammatory Disorders Co-sponsored by Biliary Disorders

CHRONIC U L C E R A T I V E COLITIS

Chairs: Stephen P. James, Claudio Fiocchi

P a t h o p h y s i o l o g y of c h r o n i c u l c e r a t i v e colitis. R. Balfour Sartor. Chapel Hill, NC

New m e d i c a l t h e r a p y for c h r o n i c u l c e r a t i v e colitis. Simon Lichtiger. New York, NY Advances a n d c o n t r o v e r s i e s i n s u r g e r y for c h r o n i c u l c e r a t i v e colitis. Mark L. Welton. San Francisco, CA AGA Clinical Symposium

4:00-5:30pm

Room 9 0 / 9 1 / 9 2 Ernest N. Morial Convention Center

Sponsored by Clinical Practice Co-sponsored by Esophageal, Gastric, and Duodenal Disorders Chair:

Denis McCarthey

4:00-5:30 p m

Room 85/86 Ernest N. Morial Convention Center

IMMUNE-NON-IMMUNE INTERACTIONS IN INTESTINAL INFLAMMATION Tissue m i c r o e n v i r o n m e n t s c o n t r o l a c t i v a t e d T cell apoptosis. AN Akbar. London, England T Cell i n t e r a c t i o n s w i t h the e x t r a c e l l u l a r m a t r i x : The ins a n d outs of i n t e g r i n signaling. Yoji Shimizu. Minneapolis, MN Matrix m e t a l l o p r o t e i n a s e s i n g u t i n j u r y . Thomas J. MacDonald. London, England Altered f i b r o b l a s t a n d ECM f u n c t i o n i n i n f l a m m a t o r y bowel disease. Claudio Fi0cchi. Cleveland, OH AGA Topic Forum

4:00-5:30 p m

Room 33/35 Ernest N. Morial Convention Center

O U T C O M E S IN GASTROESOPHAGEAL REFLUX

Chairs: Claus Niederau, Richard V. Benya Lessons from the n a t u r a l h i s t o r y of reflux disease. Amnon Sonnenberg. Albuquerque, NM Outcomes of e n d o s c o p y i n GERD. David A. Lieberman. Portland, OR Costs of t r e a t m e n t a l t e r n a t i v e s . Nimish B. Vakil. Milwaukee, Wi Q u a l i t y of life as a n o u t c o m e i n GERD. Michael J. Shaw. Golden Valley, MN Q u e s t i o n s a n d Answers.

RECEPTOR B I N D I N G DOMAINS 4:00

I n t r i n s i c p h o t o a f f i n i t y l a b e l i n g of the cholecystokinin receptor provided dual c o n s t r a i n t s for m o d e l i n g the l i g a n d - b i n d i n g site. (Abstract# G1896) EM Hadac, DI Pin0n, Z Ji, EL H01icky, T Lybrand and LJ Miller. Rochester, MN and Seattle, WA

4:15

Direct identification of a l i g a n d - b i n d i n g d o m a i n w i t h i n the r a t secretin receptor by i n t r i n s i c photoaffinity labeling. (Abstract# G1846) M Dong, EM Hadac, DI Pinon and LJ Miller. Rochester, MN

4:30

Vasoactive i n t e s t i n a l p e p t i d e s t r u c t u r a l r e q u i r e m e n t s for h i g h affinity i n t e r a c t i o n with the VIP r e c e p t o r i n p a n c r e a t i c acini. (Abstract# G1914) T Ite, SA Mantey, D Coy, N-Y Jiang, J Fuselier and RT Jensen. Bethesda, MD and New Orleans, LA

4:45

The o r p h a n receptor, BRS-2, causes t y r o s i n e p h o s p h o r y l a t i o n of focal a d h e s i o n k i n a s e (p125FAK). (Abstract# G4707) W Hou, RR Ryan, DH Coy and RT Jensen. Bethesda, MD and New Orleans, LA

5:00

The s o m a t o s t a t i n r e c e p t o r s u b t y p e 3 acts as a n acceptor of vasoactive i n t e s t i n a l peptide. (Abstract# G4793) M Peck-Rad0savljevic, Q Yang, M Leimer, C Bischof, D Gludavacz, T Pengerl, M Wichlas, J Himpf, J Pidlich, P Valent and I Virgolini. Vienna, Austria

5:15

L i t h o c h o l y l t a u r i n e , a c o n j u g a t e d 3a-mono (hydroxy) bile acid, b i n d s to M S s u b t y p e m u s c a r i n i c cholinergic receptors. (Abstract# G4610) A Bartoszko-Malik, P Zimniak and J-P Raufman. Little Rock, AR

AGA Research Symposium

4:00-5:30 p m

Room 28 Ernest N. Morial Convention Center

Sponsored by Motility and Nerve-Gut Interactions Co-sponsored by Biliary Disorders and Pancreatic Disorders Chair:

Gary Mawe

THE E N T E R I C N E R V O U S SYSTEM AND ITS FRIENDS: LINKS W I T H ACCESSORY ORGANS AND P R E V E R T E B R A L GANGLIA I n t r i n s i c s e n s o r y neurons. Michael D. Gershon. New York, NY G a l l b l a d d e r a n d s p h i n c t e r of Oddi. Gary M. Mawe. Burlington, VA Pancreas Annette Kirchgessner. New York, NY P r e v e r t e b r a l s y m p a t h e t i c ganglia. Keith A. Sharkey. Calgary, Canada

G A S T R O E N T E R O L O G Y Vol. 114 r No. 4

P106 P R O G R A M OF THE ANNUAL M E E T I N G

MONDAY, MAY 18, 1998 AASLD Research Forum

4:00-5:30 p m

4:45

Alkaline phosphatase regulates secretory p r o c e s s e s in r a t i n t r a h e p a t i c b i l i a r y e p i t h e l i u m . (Abstract# L0017) D Alvaro, A Benedetti, S Glaser, A Caligiuri, L Marucci, E Papa, A Gigliozzi, F Fraioli, J Phinizy, G LeSage and G Alpini. Rome and Ancona, Italy; Temple, TX

5:00

U r s o d e o x y c h o l i c a c i d f e e d i n g j n h l b i t s secretini n d u c e d c h o l a n g i o c y t e s e c r e t o r y p r o c e s s e s in bile d u c t l i g a t e d r a t s . (Abstract# L0016) G Alpini, S Glaser, A Caligiuri, J Phinizy, R Rodgers, H Francis, W Robertson, E Papa, J Lasater and G LeSage. Temple, TX

5:15

Effect of c h o l e s t a s i s on i l e a l a b s o r p t i o n of bile a c i d s a n d on i l e a l b i l e a c i d t r a n s p o r t e r i n r a t . (Abstract# L0557) P Sauer, A Stiehl, P Kloeters-Plachky, BA Fitscher, HD Riedel, C Benz, S Stengelin, W Stremmel and W Kramer. Heidelberg and Frankfurt, Germany

Room 93/94 Ernest N. Morial Convention Center

Chairs: W. Scott Helton, William C. Meyers HEPATOBILIARY SURGERY 4:00

L i v e r adenomatosiso (Abstract# L0132) T Dao, L Chiche, MP Galais, P Rousselot, E Salame and P Segol. Caen, France

4:15

M a n a g e m e n t of l i v e r a d e n o m a t o s i s : p a r t i a l r e s e c t i o n o r l i v e r t r a n s p l a n t a t i o n ? (Abstract# L0528) A Ribeiro, LJ Burgart, DM Nagorney and GJ Gores. Rochester, MN

4:30

4:45

5:00

5:15

H e p a t i c a d e n o m a o r focal n o d u l a r h y p e r p l a s i a . A d i f f e r e n t i a l d i a g n o s t i c p r o b l e m . (Abstract# L0231) PMEM Hendriks, FM vd Zant, TM van Gulik and DJ Gouma. Amsterdam, The Netherlands Hepatocyte proliferative index correlates with t h e r i s k of d e v e l o p i n g HCC i n c i r r h o t i c s . (Abstract# L0550) A Sangiovanni, E Colombo, F Radaelli, N Terreni, GC Spinzi, A Casiraghi, R Ceriani, A Prada, E Tavani and G Minoli. Como and Milan, Italy Two-stage h e p a t e c t o m y for m e t a s t a s e s of d i g e s t i v e e n d o c i n e t u m o r s . (Abstract# L0167) O Farges, AR Kianmanesh, I Madeira, P Bernades, P Ruszniewski and J Belghiti. Clichy, France P r o m i s i n g l o n g t e r m efficacy of p a l l i a t i v e TIPS t r e a t m e n t for h e p a t o r e n a l s y n d r o m e in nont r a n s p l a n t a b l e c i r r h o t i c s . (Abstract# L0072) KA Brensing, J Textor, J Perz, P Schiedermaier, P Raab, H Strunk, HU Klehr, HJ Kramer, U Spengler, H Schild and T Sauerbruch. Bonn, Germany

Growth, Development, Nutrition AGA Research Forum

4:00=5.'30 p m

Chairs: Hannah V. Carey, M. James Lopez MUCOSAL GROWTH FACTORS 4:00

E G F r e c e p t o r - a n d MAP k i n a s e - d e p e n d e n t inter-regulation within the immediate-early t r e f o i l gene family. (Abstract# G3731) D Taupin, W-K Jeon, TC Wang and DK Podolsky. Boston, MA

4:15

Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal e p i t h e l i a l cell line. (Abstract# G3699) DB P01k and W Tong. Nashville, TN

4:30

R e g u l a t i o n of t i g h t j u n c t i o n f o r m a t i o n in i n t e s t i n a l e p i t h e l i a l cells b y t h e IL-15 ligandr e c e p t o r system. (Abstract# G3680) R Nishiyama, DK Pod01sky and HC Reinecker. Boston, MA

4:45

R a s - m e d i a t e d s u p p r e s s i o n of T G F ~ R I I occurs b y a R a f - i n d e p e n d e n t p a t h w a y . (Abstract# G3561) N Bulus, N Sizemore, M Peterson, RD Beauchamp and JA Barnard. Nashville, TN

5:00

E n t e r a l IGF-I i n c r e a s e s NaC1 fluxes a n d e n t e r o c y t e Ha÷,K÷-ATPase a c t i v i t y i n n o e n a t a l p i g j e j u n u m . (Abstract# G3545) AN Alexander and HV Carey. Madison, WI

5:15

The t u m o r n e c r o s i s f a c t o r - a a n t i p r o l i f e r a t i v e effect, t h e a c t i v a t i o n of MAP k i n a s e a n d t h e n u c l e a r t r a n s l o c a t i o n of NF-KB a r e i n h i b i t e d b y 5-aminosalicylic acid. (Abstract# G3636) GC Kaiser and DB Polk. Nashville, TN

AASLD Research Forum

4:00-5:30 p m

Room 95/96 Ernest N. Morial Convention Center

Chairs: Frederick J. Suchy, M. Sawkat Anwer BILE FORMATION AND CHOLESTASIS 4:00

I d e n t i f i c a t i o n of a novel n e g a t i v e - a c t i n g cytokine response element in the rat liver soditun-dependent bile acid cotransporter gene p r o m o t e r . (Abstract# L0138) LA Denson, MH McClure and SJ Karpen. New Haven, CT

4:15

Mouse Ntcp (Na+-taurocholate c o t r a n s p o r t i n g p o l y p e p t i d e ) gene: e x o n / i n t r o n o r g a n i z a t i o n , promoter stucture and chromosomal l o c a l i z a t i o n . (Abstract# L0019) M Ananthanarayanan, T P0tseleuva, RM Green and F J Suchy. New York, NY and Boston, MA

4:30

P r e f e r e n t i a l l o c a l i z a t i o n of phosphatidylcholine in micellar and sphingomyelin in vesicular phases: implications for canalicular bile formation. (Abstract# L0159) ERM Eckhardt, SS G0erdayal, W Ren00ij, GP van Berge Heneg0uwen and KJ van Erpecum. Utrecht, The Netherlands

Room 20 Ernest N. Morial Convention Center

April 1998

PROGRAM OF THE ANNUAL MEETING P107

MONDAY, MAY 18, 1998 Gastrointestinal Oncology AGA Research Forum

4:00-5:30 p m

4:45

Effects of diclofenac a n d L-745,337, a selective cyclooxygenase-2 i n h i b i t o r , o n p r o s t a g l a n d i n E 2 f o r m a t i o n i n t i s s u e from h u m a n colonic m u c o s a a n d c h r o n i c b u r s i t i s . (Abstract# G0570) B Gretzer, H Kn0rth, M Chantrain, L Barbera, RE Willburger, RH Wittenberg and BM Peskar. Bochum, Germany

5:00

P r e v e n t i o n of gastric d a m a g e b y NO-releasing a s p i r i n (NCX-4016) is m e d i a t e d b y i n h i b i t i o n of ICE-like proteases i n g a s t r i c m u c o s a a n d e n d o t h e l i a l cells. (Abstract# G0500) S Fi0rucci, E Antonelli, O M0relli, B Federici and A Morelli. Perugia, Italy

5:15

Effects of NO-releasing a s p i r i n o n f u n c t i o n a l a n d mucosal u l c e r o g e n i c r e s p o n s e s i n t h e r a t stomach: c o m p a r i s o n w i t h a s p i r i n . (Abstract# G1287) H Ukawa, A Tanaka, H Yamamoto, M Nishijima and K Takeuchi. Kyoto, Japan

Room 13 / 15 / 17 Ernest N. Morial Convention Center

Chairs: David F. Ransohoff, Douglas K. Rex COLONIC A D E N O M A D E T E C T I O N AND SURVEILLANCE 4:00

4:15

4:30

4:45

5:00

5:15

Distal t u b u l a r a d e n o m a s f o u n d on s c r e e n i n g sigmoidoscopy are n o t m a r k e r s for p r o x i m a l a d v a n c e d neoplasia. (Abstract# G2614) T Levin, J Selby, S Grossman, C C0nell, L Finkler, M Lawson and A Palitz. Oakland and San Francisco, CA I n c i d e n c e of colorectal c a n c e r d u r i n g colonoscopic s u r v e i l l a n c e i n a four-year polyp p r e v e n t i o n trial. (Abstract# G2883) RU van Stolk, M Beach, JA Baron and ER Greenberg. Cleveland, OH and Lebanon, NH The a s s o c i a t i o n of colonic h y p e r p l a s t i c polyps w i t h t h e r e c u r r e n c e r a t e of colonic a d e n o m a s a n d h y p e r p l a s t i c polyps. (Abstract# G2312) S Bensen, B Cole, L M0tt and J Baron. White River Junction, VT and Lebanon, NH R i s k - r e l a t e d s u r v e i l l a n c e of p a t i e n t s with colorectal a d e n o m a s . (Abstract# G2704) G Nusko, U Mansmann, U Partzsch, T Kirchner and EG Hahn. Erlangen and Berlin, Germany Small colon a d e n o m a s : m o r e t h a n meets the eye. (Abstract# G2363) MP Chase, GS Fiarman and LF Butterly. Burlington, MA C o r r e l a t i o n of i m m u n o s t a i n i n g (Ki-67, p53, Adnab-9) a n d ploidy w i t h morphology, multiplicity, invasiveness and recurrence in d y s p l a s t i c colo-rectal polyps. (Abstract# G2801) R Sheikh, B Min, R Teplitz, H Teslok, M Tobi, B Ruebner and M Lawson. Davis and Sacramento, CA; Detroit, MI

Esophageal, Gastric, and Duodenal Disorders

Esophageal, Gastric, and Duodenal Disorders AGA Research Forum

4:00-5:30 p m

Chairs: Mitchell L. Schubert, Andrea Todisco CELL BIOLOGY OF ACID S E C R E T I O N 4:00

cDNA t r a n s f e c t i o n a n d p r o t e i n e x p r e s s i o n i n p r i m a r y c u l t u r e s of gastric p a r i e t a l cells. (Abstract# G1040) JA Parente, Jr, S Bernatz, X Chen and CS Chew. Augusta, GA

4:15

S t r u c t u r a l - f u n c t i o n a l r e l a t i o n s h i p s for the ~s u b u n i t of the H,K-ATPase. (Abstract# G0484) CJ Fan, DC Chow and JG Forte. Berkeley, CA

4:30

I d e n t i f i c a t i o n of the loop r e g i o n b e t w e e n TM5 a n d TM6 of the H,K ATPase u s i n g cysteine m u t a g e n e s i s . (Abstract# G0795) N Lambrecht, Z C0rbett, D Bayle, SJD Karlish and G Sachs. Los Angeles, CA

4:45

I d e n t i f i c a t i o n of the ROMK c h a n n e l i n m a m m a l i a n p a r i e t a l cells. (Abstract# Gl103) EB Rodas, GR Ortega, AM Qureshi, GG MacGregor, JZ Xu, SC Hebert and JP Geibel. New Haven, CT and Nashville, TN

5:00

Different r e c e p t o r s u b t y p e s m e d i a t e PYYi n d u c e d i n h i b i t i o n of gastric acid a n d p e p s i n secretion. (Abstract# Gl193) TE Solomon, JR Reeve, Jr, D Grandt, L Bussjaeger, G Varga and JH Walsh. Los Angeles, CA

5:15

Corpus h i s t i d i n e decarboxylase activity is i n c r e a s e d i n h y p o t h y r o i d i s m . (Abstract# G1401) PQ Yuan, Y Tach6, G Ohning and H Yang. Los Angeles, CA

AGA Research Forum

4:00-5:30 p m

Room 21 Ernest N. Morial Convention Center

Chairs: John L. Wallace, Lenard M. Lichtenberger BASIC M E C H A N I S M S OF NSAID-INDUCED INJURY 4:00

Indomethacin-inducedgastropathy in a d h e s i o n molecule-deficient mice. (Abstract# G0956) Z Morise, DN Granger, DC Anderson and MB Grisham. Shreveport, LA and Kalamazoo, MI

4:15

I n d o m e t h a c i n (Indo) a n d bile salts compete for the biliary phosphatidycholine: an explanation of I n d o - i n d u c e d i n t e s t i n a l i n j u r y . (Abstract# G0271) J-M Barrios and LM Lichtenberger. Houston, TX

4:30

A n i m p o r t a n t c o n t r i b u t i o n of cyclooxygenase-1 to i n f l a m m a t o r y r e s p o n s e s i n rats a n d mice: i m p l i c a t i o n s for GI toxicity. (Abstract# G1336) JL Wallace, A Bak, W McKnight, S Asfaha, KA Sharkey and WK MacNaughton. Calgary, Canada

Room 24 Ernest N. Morial Convention Center

G A S T R O E N T E R O L O G Y Vol. 114, No. 4

P I 0 8 P R O G R A M OF T H E A N N U A L M E E T I N G

MONDAY, MAY 18, 1998 Intestinal Disorders AGA Research Forum

4:00-5:30 p m

4:30

K-ras m u t a t i o n , p53 a n d c-ErbB-2 overexpression i n the n e o p l a s t i c p r o g r e s s i o n of i n t r a d u c t a l p a p i l l a r y - m u c i n o u s t u m o r s of the p a n c r e a s . (Abstract# G2842) S Taylor, A Gown, LW Traverso, R Kozarek, T Brentnall and MP Bronner. Seattle, WA

4:45

Multiple p a t h w a y s for n e o p l a s t i c e v o l u t i o n i n colorectal neoplasia: K-Ras m u t a t i o n s are associated w i t h exophytic n e o p l a s t i c lesions. (Abstract# G2929) M Yashiro, L Laghi, K Saito, JM Carethers, A Randolph, C Chang, DP Chauhan, L Ricciardiello, P Slezak, E Jaramill 0, C Rubio, K Koizumi and CR Boland. San Diego, CA and Stockholm, Sweden

5:00

H y p o m e t h y l a t i o n of the MUC2 gene p r o m o t e r is the c o m m o n genetic p r o p e r t y of the m u c i n o u s c a r c i n o m a cells of the colon a n d m a m m a . (Abstract# G2475) A Gratchev, C B6hm, EO Riecken and C Hanski. Berlin, Germany The role of c-/dt m u t a t i o n s i n h u m a n gastroi n t e s t i n a l s t r o m a l t u m o r s . (Abstract# G2839) M Taniguchi, T Nishida, T Ite, T Nomura, S Hirota, Y Kitamura and H Matsuda. Osaka, Japan

Room 61 / 62 / 63 Ernest N. Morial Convention Center

Chairs: Stefano Guandalini, Kenneth D. Fine CLINICAL ADVANCES IN INTESTINAL DISORDERS I 4:00

Celiac disease a u t o a n t i b o d i e s a n d tissue transglutaminase antibodies interfere s i m i l a r l y f i b r o b l a s t - i n d u c e d epithelial cell (T84) d i f f e r e n t i a t i o n . (Abstract# G1538) T Halttunen and M M~ki. Tampere, Finland

4:15

Molecular a n a l y s i s of c l o n a l i t y of muscosal T cells i n celiac disease. (Abstract# G1455) F Carbonnel, L Bioul, JC Brouet, J Cosnes, H d'Almagne, MF Teilhac, M Deschaseaux, JP Gendre and F Sigaux. Paris, France

4:30

Cholylsarcosine i m p r o v e s fat a b s o r p t i o n i n s h o r t bowel s y n d r o m e . (Abstract# G1531) C Gruy-Kapral, KH Little, JS Fordtran, LR Hagey and AF Hofmann. Dallas, TX and San Diego, CA

5:15

Long t e r m efficacy of i n t e s t i n a l t r a n s p l a n t a t i o n i n p a t i e n t s with end-stage g a s t r o i n t e s t i n a l failure. (Abstract# G1414) K Abu-Elmagd, J Reyes, S Todo, K Lee, J Demetris, N Murase, J Rakela, J Fung and T Starzl. Pittsburgh, PA

Growth, Development, Nutrition AGA Research Forum

4:45

5:00

5:15

P r e l i m i n a r y e v a l u a t i o n of 13C-sorbitol b r e a t h test i n d i a g n o s i s of small bowel b a c t e r i a l overgrowth. (Abstract# G1702) L Somogyi, S Amann, DA Wagner and PP Toskes. Gainesville, FL and Merrimack, NH Altered g l i a d i n p e p t i d e b i n d i n g to small i n t e s t i n a l b r u s h b o r d e r m e m b r a n e s i n celiac disease is i n d e p e n d e n t of disease activity. (Abstract# G1441) G Bolte, K Beuermann and M Stern. Tiibingen, Germany

4:00-5:30 p m

Chairs: Charles H. Halsted, Alan L. Buchman NUTRITION: CLINICAL 4:00

Can lactose m a l d i g e s t e r s t o l e r a t e t h e i n g e s t i o n of a d a i r y - r i c h diet c o n t a i n i n g a p p r o x i m a t e l y 1500 m g calcium/day? (Abstract# G3727) FL Suarez, J Adshead, JK F u m e and MD Levitt. Minneapolis, MN

4:15

Nutritional assessment parameters in patients a w a i t i n g liver t r a n s p l a n t a t i o n - c o r r e l a t i o n with b o d y cell mass. (Abstract# G3569) MR Charlton, D Higgins, P Pasha, S DiCecco, N Francisco-Ziller and ER Dickson. Rochester, MN

4:30

Is d i a r r h e a c o m p l i c a t i n g b o l u s n a s o g a s t r i c t u b e f e e d i n g caused b y a n a b n o r m a l PYY response? (Abstract# G3594) H Duncan, S Cole, T Bowling, M Ghatei, S Bloom and D Silk, London, United Kingdom

4:45

T r e a t m e n t of severe s h o r t bowel s y n d r o m e w i t h h i g h dose growth h o r m o n e a n d g l u t a m i n e . (Abstract# G3730) J Szkudlarek, PB Jeppesen and PB Mortensen. Copenhagen, Denmark

5:00

Does a n a s o g a s t r i c t u b e a d v e r s e l y affect distal colonic m o t i l i t y a n d c o n t r i b u t e to pathogenesis of e n t e r a l feeding-related d i a r r h e a ? (Abstract# G3593) H Duncan, S Cole, T Bowling and D Silk. London, United Kingdom

5:15

Clinical outcome of home p a r e n t e r a l n u t r i t i o n : the Mayo Clinic's t w e n t y - y e a r experience. (Abstract# G3721) JS Scolapi0, CR Fleming, DG Kelly, D Wick and AR Zinsmeister. Jacksonville, FL and Rochester, MN

Gastrointestinal Oncology AGA Research Forum

4:00-5:30 p m

Room 80/81 Ernest N. Morial Convention Center

Chairs: Teresa A. BrentnaU, Russell F. Jacoby MOLECULAR P A T H O G E N E S I S OF G A S T R O I N T E S T I N A L CANCER 4:00

4:15

I1307K adenomatouspolyposis coil gene m u t a t i o n i n colorectal c a n c e r p a t i e n t s with a family h i s t o r y or e a r l y o n s e t of colorectal c a n c e r a t t e n d i n g a family c a n c e r clinic i n L o n d o n . (Abstract# G2400) I Dove-Edwin, I Frayling and HJW Thomas. Harrow, United Kingdom C o o p e r a t i o n b e t w e e n the cyclin D1 oncogene a n d t h e chemical c a r c i n o g e n Nn i t r o s o m e t h y l b e n z y l a m i n e i n the i n d u c t i o n of esophageal d y s p l a s i a i n t r a n s g e n i c mice. (Abstract# G2534) TD Jenkins, A MueUer, R Odze, A Shahsafaei, L Zukerberg, G Stoner and AK Rustgi. Boston, MA and Columbus, OH

Room 82/83 Ernest N. Morial Convention Center

April1998

PROGRAMOFTHEANNUALMEETINGP109

LI

MONDAY, MAY 18, 1998

Pancreatic Disorders AGA Research Forum

4:00-5:30 p m

IBD Forum Symposium

6:30-8:00 p m

Room 88 Ernest N. Morial Convention Center

Moderators:

Chairs: John A. Williams, Herbert Y. Gaisano

4:15

4:30

4:45

William J. Sandborn. Rochester, M N Robin S. McLeod. Toronto, Canada

M A N A G E M E N T OF COMPLEX PERIANAL CROHN'S DISEASE IN T H E N E W M I L L E N N I U M

I N T E G R A T E D PANCREATIC PHYSIOLOGY 4:00

Grand Salon D N e w Orleans Hilton Riverside Hotel

SNARE p r o t e i n s (Munc 18c/syntaxin-4/SNAP23/VAMP-2) m e d i a t e b a s o l a t e r a l p l a s m a m e m b r a n e exocytosis d u r i n g e x p e r i m e n t a l a c u t e p a n c r e a t i t i s . (Abstract# G1873) HY Gaisano, J Leser, L Sheu, Y Tamori, WS Trimble and MP Lutz. Toronto, Canada; Ulm, Germany and Kobe, Japan

CASE STUDIESTO BE PRESENTED: 6:30

P e r i a n a l f i s s u r e a n d s k i n tags. Moderator: Dr. Sandborn

6:45

Anal stenosis. Moderator: Dr. McLeod

E n d o c y t o s i s at t h e apical p l a s m a m e m b r a n e of the p a n c r e a t i c a c i n a r cell is r e g u l a t e d b y a complex of GP2 a n d SRC kinases. (Abstract# G1865) SD Freedman, EM Parker and MH Katz. Boston, MA

7:00

Simple fistula. Moderator: Dr. McLeod

7:15

Complex p e r i a n a l disease i n c l u d i n g abscesses a n d m u l t i p l e fistulae. Moderator: Dr. Sandborn

C h a r a c t e r i z a t i o n of the i n t r a c e l l u l a r p r o c e s s i n g of t h e p a n c r e a t i c zymogen g r a n u l e m e m b r a n e p r o t e i n , GP-2. (Abstract# G1866) BA Fritz and AW L0we. Stanford, CA

7:30

R e e t o v a g i n a l fistula. Moderator: Dr. Sandborn

7:45

U n h e a l e d p e r i a n a l w o u n d following proctocolectomy. Moderator: Dr. McLeod

E l u c i d a t i o n of the c e l l u l a r d i s t r i b u t i o n of secretin receptor expression in rat pancreas via in sltu r e c e p t o r a u t o r a d i o g r a p h y . (Abstract# G2076) D Whitc0mb, P Wood, LJ Miller and C Ulrich. Pittsburgh, PA; Rochester, MN and Cincinnati, OH

5:00

Intraduodenal soybean lectin stimulates l u m i n a l CCK-releasing p e p t i d e (diazepamb i n d i n g i n h i b i t o r ) s e c r e t i o n via a cholinergic p a t h w a y i n rats. (Abstract# G1814) CC Chen, YB Hao, Y Li and C Owyang. Taipei, Taiwan and Ann Arbor, MI

5:15

Role of s e r o t o n i n p a t h w a y i n the m e d i a t i o n of p o s t p r a n d i a l p a n c r e a c t i c enzyme secretion i n h u m a n s . (Abstract# G1932) TN Kim and C Owyang. Ann Arbor, MI

AGA Section Business Meetings

5:30-6:30 p m

Ernest N. Morial Convention Center Members only

Hormones, T r a n s m i t t e r s , G r o w t h Factors, a n d t h e i r R e c e p t o r s M o t i l i t y a n d Nerve-Gut Interactions E s o p h a g e a l , Gastric, a n d Duodenal Disorders Intestinal Disorders

R o o m 22 R o o m 28 R o o m 88 R o o m 99

Panelists: Zane Cohen. Toronto, Canada Victor Fazio. Cleveland, OH Brian Feagan. London, Canada Derek P. Jewell. Oxford, England Keith A. Kelly. Scottsdale, A Z Fabrizio Michelassi. Chicago, IL Daniel H. Present. New York, N Y Ernest Seidman. Montreal, Canada

G A S T R O E N T E R O L O G Y V o l . 113 t N o . 4

P l l 0 PROGRAM OF THE AN-NIJALM E E T I N G

It

U

TUESDAY, MAY 19, 1998 AMERICAN SOCIETY FOR GASTROINTESTINAL ENDOSCOPY

ASGE Topic Forum

ASGE Clinical Symposium

8:00-9:30 am

8:30-10:00 am

Ballroom C Ernest N. Morial Convention Center

Room 6 4 / 6 5 / 6 6 Ernest N. Morial Convention Center

Chairs: Ian Gralnek, S.C. Sydney Chung

Chairs: Firas H. Al-Kawas, Christopher J. Gostout

GI B L E E D I N G

ENDOSCOPIC MUCOSAL RESECTION/ABLATION

Attendees will learn new information about the endoscopic management of esophageal varices and peptic ulcer disease. Attendees will learn new information about triage of patients with non-variceal UGI bleeding based on endoscopic findings.

Attendees will learn about new methods for resection of mucosal lesions. Perspectives from surgeons and gastrointestinal specialists will be presented to provide attendees knowledge about which lesions are best treated with mucosal resection.

8:00

8:13

8:26

8:39

8:52

9:05

F i n a l r e s u l t s of a r a n d o m i z e d prospective s t u d y of c o m b i n a t i o n b a n d i n g a n d sclerot h e r a p y v e r s u s s c l e r o t h e r a p y alone for h e m o s t a s i s of b l e e d i n g esophageal varices. (Abstract# 184) DM Jensen, R Jutabha, TOG Kovacs, GA Machicado, I Gralnek, S Chung, ME Jensen and J Gornbein. Los Angeles, CA B a n d i n g is s u p e r i o r to c y a n o a c r y l a t e for the t r e a t m e n t of esophageal variceal bleeding: a p r o s p e c t i v e r a n d o m i z e d study. (Abstract# 210) JY Sung, YT Lee, R Suen and SCS Chung. Hong Kong, China S c h e d u l e d endoscopic r e t r e a t m e n t versus single i n j e c t i o n t h e r a p y i n b l e e d i n g gastrod u o d e n a l ulcers: r e s u l t s of a m u l t i c e n t e r study. (Abstract# 235) C Ell and the German Ulcer Bleeding study group. Wiesbaden, Germany P r e v a l e n c e a n d p r o g n o s t i c significance of s t i g m a t a of b l e e d i n g i n p a t i e n t s w i t h gastric ulcers w i t h o u t overt h e m o r r h a g e o n p r e s e n t a t i o n . (Abstract# 225) EJ Bini, JM Rieber and J Cohen. New York, NY Safety of o u t p a t i e n t m a n a g e m e n t of non• v a r i c e a l u p p e r g a s t r o i n t e s t i n a l bleeding. P r e l i m i n a r y r e s u l t s of a r a n d o m i z e d study. (Abstract# 228) R Campo, E Brullet, X Calvet, L Catot, J Cabrol, E Laporte and CHP Tauli. Sabadell, Spain STATE OF THE A R T LECTURE:

C o n t r o v e r s i e s i n u p p e r GI bleeding. SC Sydney Chung. Hong K0ng, China

8:30

What are the issues i n 1998. Firas H. A1-Kawas. Washington, DC

8:35

Review of e x p e r i m e n t a l e n d o s c o p i c techniques. Christopher J. Gostout. Rochester, MN

8:40

How c a n we i d e n t i f y the lesion r e q u i r i n g mucosal r e s e c t i o n ? Gregory G. Ginsberg. Philadelphia, PA

8:55

The pathologist perspective: w h a t are t h e lesions a n d h o w m u c h s h o u l d be r e m o v e d ? Theresa Em0ry. Washington, DC

9:10

Is endoscopic m u c o s a l r e s e c t i o n realistic? A surgeon's perspective. David W. McFadden. Los Angeles, CA

9:25

Endoscopic t e c h n i q u e s : r e s u l t s a n d limitations. Kenneth F. Binmoeller. Hamburg, Germany

9:40

P a n e l d i s c u s s i o n a n d questions.

DDW Combined Clinical Symposium

8:30-10:00 am

Ballroom A / B Ernest N. Morial Convention Center

Sponsored by: AGA/ASGE

Chairs: Michael Camilleri, Kenneth McQuaid G A S T R I C DYSPEPSIA 8:30

Cost-effective a p p r o a c h to d y s p e p s i a a n d the p o t e n t i a l i m p a c t of small scopes. Josh Ofman. Beverly Hills, CA

8:45

C u r r e n t a n d f u t u r e role of e n d o s c o p y i n dyspepsia. Peter Bytzer. Glostrap, Denmark

9:00

Critical a p p r a i s a l of c u r r e n t t h e r a p i e s . Kenneth McQuaid. San Francisco, CA

9:20

Sensation, a c c o m m o d a t i o n , a n d n e w approaches to therapy. Michael Camilleri. Rochester, MN

April 1998

PROGRAMOF THEANNUALMR,WrINGPUl

TUESDAY, MAY 19, 1998 ASGE Topic Forum

DDW Combined Clinical Symposium

9:30-11:00 am

10:30 am-12:00 p m

Ballroom C Ernest N. Morial Convention Center

Room 9 0 / 9 1 / 9 2 Ernest N. Morial Convention Center

Chairs: John J. Brandabur, James T. Frakes

S p o n s o r e d by: ASGE/AGA/SSAT

ERCP

Chairs: Blair S. Lewis, Donald C. Rockey

Attendees will learn about new advances in the management of malignant obstruction, biliary tract stones and sphincter of Oddi dysfunction. Attendees will learn new information regarding management of sphincter of Oddi dysfunction.

OCCULT GI B L E E D I N G

9:30

' ~ r a n n e n b a u m " teflon s t e n t s versus t r a d i t i o n a l p o l y e t h y l e n e s t e n t s for t r e a t m e n t of m a l i g n a n t b i l i a r y s t r i c t u r e s : a m u l t i c e n t e r , prospective r a n d o m i z e d trial. (Abstract# 394) SM Meyerson, JE Geenen, MF Catalano, MJ Schmalz, DJ Geenen, J Seigel, L Jacob, MH McKinley, I Raijman, P Meier, I Jacobson, R Kozarek, G Lehman, F A1-Kawas, S Lo, KS Dua, J Baillie, D Carr-Locke, G Ginsberg, W Parsons, S Cohen, D Nelson and JD McHattie. Milwaukee, WI

9:43

P e r o r a l endoscopic f r a g m e n t a t i o n of bile d u c t s t o n e s w i t h e l e c t r o h y d r a u l i c lithotripsy. (Abstract# 401) SE Nelles, GB Haver, YI Kim and PK Kortan. Toronto, Canada

9:56

E n d o s c o p i c i n j e c t i o n of b o t u l i n u m t o x i n for b i l i a r y s p h i n c t e r of Oddi dysfunction. A p r o s p e c t i v e study. (Abstract# 429) T Wehrmann, H Seifert, M Seipp, B Lembcke and WF Caspary. Frankfurt, Germany

10:09

10:22

10:35

10:48

S p h i n c t e r of Oddi d y s f u n c t i o n : c o m b i n e d p a n c r e a t o b i l i a r y t h e r a p y has a lower postp r o c e d u r e p a n c r e a t i t i s r a t e t h a n pull-type b i l i a r y s p h i n c t e r o t o m y . (Abstract# 358) D Eversman, E Fogel, K Gottlieb, S Sherman and G Lehman. Indianapolis, IN B a c t e r e m i a after endoscopic r e t r o g r a d e c h o l a n g i o p a n c r e a t o g r a p h y : a prospective s t u d y u s i n g a h i g h blood volume c o n t i n u o u s m o n i t o r i n g c u l t u r e system. (Abstract# 344) GMR Campos, B Herani Filho, CAP Pereira, AMO Machado and MCC Baretta. Sao Paulo, Brazil Selection of a p p r o a c h r o u t e for diagnosis a n d n o n - s u r g i c a l m a n a g e m e n t of m a l i g n a n t h i l a r b i l i a r y o b s t r u c t i o n : ERC or PTC? (Abstract# 434) BM Yoo, JH Kim, YJ Shin, KB Hahm and SW Cho. Suwon, Korea STATEOF TI-~ ART LECTURE: Title TBA Kenneth F. Binmoeller. San Diego, CA

Attendees will learn about appropriate diagnostic tests to evaluate patients with occult GI bleeding and iron deficiency. New information about medical hormonal therapies, endoscopic therapy and the role of surgery will be discussed. 10:30

I n t r o d u c t i o n a n d overview. Donald C. Rockey. Durham, NC

10:40

Diagnostic a p p r o a c h to t h e p a t i e n t with occult GI bleeding. John Morris. Glasgow, Scotland

10:55

E v a l u a t i o n of i r o n deficiency a n e m i a a n d fecal occult blood. Donald C. Rockey. Durham, NC

11:10

H o r m o n a l a n d o t h e r t h e r a p i e s i n p a t i e n t s with occult GI bleeding. Blair S. Lewis. New York, NY

11:25

To o p e r a t e or n o t i n p a t i e n t s w i t h occult GI bleeding. Brian Katz. New York, NY

11:40

Discussion

DDW Combined Clinical Symposium

10:30 am-12:00 p m

Ballroom A / B Ernest N. Morial Convention Center

S p o n s o r e d by: AGA/ASGE

Chairs: Walter Peterson, M. Brian Fennerty H. PYLORI: C O N S E N S U S AND CONTROVERSY 10:30

H.p.lvlori, NSAIDs, a n d b l e e d i n g . Neville Yeomans. Footschray, Australia

10:50

A t r o p h y a n d a t r o p h i c gastritis: a n a g r e e m e n t at last? Robert Genta. Houston, TX

11:10

H. pylori a n d gastric cancer. Julie Parsonnet. Stanford, CA

11:30

H. pylori:, c u r r e n t d i a g n o s i s a n d t r e a t m e n t . Loren Laine. Los Angeles, CA

11:50

Discussion

P l 1 2 PROGRAM OF THE ANNUAL MEETING

GASTROENTEROLOGY Vol. 114~ No. 4

TUESDAY, MAY 19, 1998 ASGE Topic Forum 11:00 am-12:15 p m Ballroom C Ernest N. Morial Convention Center

Chairs: Norman E. Marcon, H. Juergen Nord

8:05

Pyloric balloon dilation. David M. Israel. Vancouver, BC, Canada

8:20

P e d i a t r i c ERCP. Moises B. Guelrud. Miami, FL

8:35

M a n a g e m e n t o f t h e difficult p o l y p , w h a t ' s new. Jerome D. Waye. New York, NY

8:50

P a n e l D i s c u s s i o n a n d Questions.

ESOPHAGUS Attendees will learn about eradication therapies for Barrett's esophagus, and treatment of therapy-induced strictures. Attendees will learn new information about management o f malignant esophageal obstruction with expandable stents. U:00

11:13

11:26

11:39

11:52

12:05

The efficacy a n d s a f e t y of a r g o n p l a s m a coagulation therapy in Barrett's esophagus. (Abstract# 21) AJ Grade, IA Shah, SM Medlin and FC Ramirez. Phoenix, AZ One y e a r follow-up a f t e r c o m p l e t e e r a d i c a t i o n of B a r r e t t ' s e s o p h a g u s u s i n g a r g o n p l a s m a c o a g u l a t i o n . (Abstract# 214) J-L Van Laethem, J Devi~re, MO Peny and M Cremer. Brussels, Belgium E x p a n d i n g m e t a l s t e n t s a r e m o r e cost effective t h a n l a s e r p h o t o a b l a t i o n t h e r a p y for p a l l i a t i o n of i n o p e r a b l e e s o p h a g e a l c a r c i n o m a . ( A b s t r a c t # 190) M Larson, E Van Os, R Balm, D Ahlquist, C Gostout, A Geller, T Viggian0, K Wang and A Zinsmeister. Rochester, MN Prospective, controlled, randomized, m u l t i c e n t e r c o m p a r i s o n of c o v e r e d a n d u n c o v e r e d e x p a n d a b l e m e t a l s t e n t s in m a l i g n a n t GE j u n c t i o n o b s t r u c t i o n . (Abstract# 212) N Vakil, A Morris, A Segalin, A Perrachia, N Marcon, G Zuccaro, J Bosco, W Jones and N Bethge. Milwaukee, WI; Liverpool, United Kingdom; Milan, Italy; Toronto, Canada; Cleveland, OH; Burlington, MA; Louisville, KY and Berlin, Germany Clinical c o u r s e of p h o t o d y n a m i c t h e r a p y i n d u c e d e s o p h a g e a l s t r i c t u r e s . (Abstract# 215) KK Wang, P Nijhawan, A Nourbakhsh, M Anderson and R Balm. Rochester, MN

ENDOSCOPIC EVALUATION FOR DYSPLASIA 9:05

I n f l a m m a t o r y b o w e l disease. Robert WyUie. Novelty, OH

9:20

Familial polyposis syndromes. Jon A. Vanderhoof. Omaha, NE

9:35

Barrett's esophagus. Robert E. Petras. Cleveland, OH

9:55

P a n e l D i s c u s s i o n a n d Questions.

ASGE Topic Forum 10:30 am-12:00 p m Room 61/62 / 63 Ernest N. Morial Convention Center

Chairs: Vasundhara Tolia, Neal LeLeiko PEDIATRIC ENDOSCOPY 10:30

Percutaneous endoscopic gastrostomy placement in medically complex infants w e i g h i n g less t h a n 3.5 k i l o g r a m s . (Abstract# 159) L Wilson and M Oliva-Hemker. Baltimore, MD

10:42

Is e s o p h a g o g a s t r o d u o d e n o s c o p y i n d i c a t e d i n e v a l u a t i o n of all cases of c a u s t i c i n g e s t i o n ? (Abstract# 153) SK Gupta, SKF Chong, JM Croffie and JF Fitzgerald. Indianapolis, IN

10:54

Acute recurrent pancreatitis in children: e v a l u a t i o n a n d t r e a t m e n t . (Abstract# 150) MF Catalano, FN Khan, E Alcocer, S Lahoti, WJ Hogan and JE Geenen. Milwaukee, WI

11:06

Clinical, m o r p h o l o g i c a l c h a r a c t e r i s t i c s , and outcome in patients with chronic pancreatitis d u e to h e r e d i t a r y p a n c r e a t i t i s a n d cystic fibrosis. (Abstract# 442) CP Choudari, GA Lehman, S Sherman, TF Imperiale, EL Fogel, NJ Nickl, WB Silverman, MF Catalano, JE Geenen, MJ Schmalz and K Block. Indianapolis, IN

11:18

Variations in assessing results of extended pH m o n i t o r i n g : is t h e r e a single b e s t m e t h o d ? (Abstract# 157) V Tolia, A Wuerth and R Thomas. Detroit, MI

11:30

Outcomes of a n t r o d u o d e n a l m a n o m e t r y catheter placement by fluoroscopy or endoscopy. (Abstract# 151) J Cocjin, C DiLorenzo, E McCloud, L Schwankovsky, J Griffiths, R Kaye and PE Hyman. Orange CA and Pittsburgh, PA

STATE OF THE ART LECTURE:

E n d o s c o p i c t h e r a p y of p r e m a l i g n a n t and m a l i g n a n t e s o p h a g e a l diseases: w h a t to do now?

Gary W. Falk. Cleveland, OH ASGE Pediatric Symposium 8:00-10:15 am Room 61/62 / 63 Ernest N. Morial Convention Center

Chairs: Marsha H. Kay, Mark Gilger THERAPEUTIC ENDOSCOPY IN CHILDREN Attendees will learn about endoscopic therapy in children including pyloric balloon dilation, ERCP and management of polyps. Attendees will learn about the management of inflammatory bowel disease, Barrett's esophagus and familial polyposis in the pediatric age group. 8:00

Introduction. Marsha H. Kay. Cleveland, OH

II

April 1998

PROGRAM OF M

ANNUAL MEETING Pl13

TUESDAY, MAY 19, 1998 2:40

Laparoscopic choledochotomy. Lawrence W. Way. San Francisco, CA

3:05

I n t e g r a t i o n o f l a p a r o s c o p i c a n d ERCP f o r c o m m o n b i l e d u c t stones. Jeffrey L. Ponsky. Cleveland, OH

ENDOSCOPIC ULTRASOUND

3:30

Discussion.

Attendees will learn new information about the role of ultrasound guided fine needle aspiration in the evaluation of lymph nodes and pancreatic cystic lesions. Attendees will learn about technologic advances in endoscopic ultrasound.

2:15-3:45 p m

ASGE Topic Forum

2:15-3:45 p m Chair:

2:15

2:28

Room 61 / 62 / 63 Ernest N. Morial Convention Center

Kenjiro Yasuda, Jacques Van Dam

E n d o s c o p i c u l t r a s o u n d - g u i d e d fine n e e d l e a s p i r a t i o n i n m e d i a s t i n a l l y m p h a d e n o p a t h y of u n k n o w n cause. (Abstract# 12) MF Catalano, F Gress, W Wassef, J Scheiman, M K0chman, E Alcocer and JE Geenen. Milwaukee, WI; Long Island, NY; Charlottesville, VA; Ann Arbor, MI and Philadelphia, PA Is t h e l i n e a r - o r i e n t e d r a d i a l s c a n n i n g e c h o e n d o s c o p e (GF-UM30-P) a d e q u a t e for p e r f o r m i n g e n d o s c o p i c u l t r a s o u n d - g u i d e d fine n e e d l e a s p i r a t i o n ? (Abstract# 60) RM Soetikno, P Nguyen and KJ Chang. Orange, CA

2:41

E U S - g u i d e d FNA w i t h cyst fluid a n a l y s i s i n p a n c r e a t i c c y s t i c lesions. (Abstract# 504) S Mallery, D Quirk, K Lewandr0wski, B Centen0, A Warshaw and WR Brugge. Boston, MA

2:54

The u s e of c o l o r D o p p l e r EUS in m o n i t o r i n g effects of v a s o a c t i v e a g e n t s on azygos b l o o d flow i n p o r t a l h y p e r t e n s i o n . (Abstract# 527) JY Sung, YT Lee and SCS Chung. H0ng Kong, China

3:07

3:20

DDW

P r o s p e c t i v e e v a l u a t i o n of e n d o s c o p i c ultrasonography, endoscopic retrograde pancreatography and secretin testing in the d i a g n o s i s of c h r o n i c p a n c r e a t i t i s . (Abstract# 477) MF Catalano, E Alcocer, S Lahoti, JE Geenen and WJ Hogan. Milwaukee, WI STATEOF THE ART LECTURE: Interventional endosonography. Kenneth J. Chang. Orange, CA Combined Clinical Symposium

2:15-3:45 p m

Ballroom A / B Ernest N. Morial Convention Center

S p o n s o r e d by: ASGE/SSAT/AASLD/AGA

Chairs: Jeffrey L. Ponsky, Lawrence W. Way MINIMALLY INVASIVE MANAGEMENT OF COMMON BILE DUCT STONES

DDW

Combined Clinical Symposium

S p o n s o r e d by: SSAT/AGA/ASGE

Chairs: Andrew L. Warshaw, Peter A. Banks SEVERE A C U T E P A N C R E A T I T I S 2:15

Medical strategy - inhibition of inflammatory mediators. James Norman. Tampa, FL

2:25

Radiologic strategy. Eric van Sonnenberg. Galveston, TX

2:35

E n d o s c o p i c s t r a t e g y - ERCP, s t e n t i n g drainage. Richard A. Kozarek. Seattle, WA

2:45

Surgical strategy - early surgery, late surgery, or no surgery. Carlos Fernandez-del Castillo. Boston, MA

2:55

Case P r e s e n t a t i o n s .

ASGE Clinical Symposium

2:15-3:45pm Chair:

2:15

Laparoscopic transcystic stone extraction. Joseph Petelin. Kansas City, KS

Ballroom C Ernest N. Morial Convention Center

David L. Carr-Locke

VIRTUAL ENDOSCOPY Attendees will learn about new information regarding the use of helical CT and magnetic resonance imaging in the evaluation of gastrointestinal tract disorders. Introduction. David L. Carr-Locke. Boston, MA U p d a t e o n t e c h n o l o g y of v i r t u a l e n d o s c o p y . Clive Kay. Charleston, SC Regulatory policy and computer-assisted imaging technologies: 1 9 9 8 F D A u p d a t e . Brian Harvey. Rockville, MD Clinical r e s u l t s . Douglas K. Rex. Indianapolis, IN Prediction for the future. Chris Beauliau. Stanford, CA Panel Discussion.

Attendees will learn about laparoscopic approaches to managing common bile duct stones, and the integration of ERCP and laparoscopic techniques.

Room 100 / 101 / 102 Ernest N. Morial Convention Center

Pn4 PROGRAM OF THE ANNUAL MEETING

G A S T R O E N T E R O L O G Y Vol. I14~ No. 4

A S G E P O S T E R S E S S I O N - - T U E S D A Y , M A Y 19, 1998 ASGE Clinical Symposium

DDW Combined Clinical Symposium

4:00-5:30 p m

4:00-5:30 p m

Chair:

Ballroom C Ernest N. Morial Convention Center

Gregory Zuccaro, Jr.

Room 100/101/102 Ernest N. Morial Convention Center

S p o n s o r e d by: SSAT/AGA/AASLD/ASGE

DEVICE R E P R O C E S S I N G

Chairs: Jon S. Thompson, Jon A. Vanderhoof

Attendees will learn important new information regarding the cleansing and reuse of endoscopic equipment and accessories.

R E C E N T ADVANCES IN THE T R E A T M E N T OF INTESTINAL F A I L U R E

4:00

R e p r o c e s s i n g of GI e q u i p m e n t : c u r r e n t a n d future techniques. Carla Aivarado. Madison, WI

4:00

Introduction.

4:10

C u r r e n t s t a t u s of medical t h e r a p y . Michael Farthing. London, England

4:20

P r o b l e m s a n d pitfalls of endoscopic reprocessing. Gregory Zuccaro, Jr. Cleveland, OH

4:30

Strategies for l e n g t h e n i n g the i n t e s t i n e i n c h i l d r e n w i t h the s h o r t bowel s y n d r o m e . Keith Georgeson. Birmingham, AL

4:40

C o m p a r i s o n of disposable vs. r e u s a b l e endoscopic accessories. Bret T. Petersen. Rochester, MN

4:50

C u r r e n t role of i n t e s t i n a l t r a n s p l a n t a t i o n . Alan Langnas. Omaha, NE

4:55

The ' r e p o s a b l e ' d o c u m e n t i n g sterility, assessing performance. Richard A. Kozarek. Seattle, WA

5:10

Discussion.

5:10

P a n e l d i s c u s s i o n a n d questions.

DDW Combined Clinical Symposium

4:00-5:30 p m

Room 9 0 / 9 1 / 9 2 Ernest N. Morial Convention Center

Sponsored by: ASGE/AGA/AASLD

Chairs: Lawrence J. Brandt, C. Melvin Wilcox HIV: GI M A N I F E S T A T I O N S Attendees will learn about the role of endoscopic procedures in the evaluation of upper and lower GI symptoms in patients with HIV infection. In addition, attendees will learn about liver disease in AIDS, and the appropriate role of liver biopsy. Finally, attendees will be exposed to new information about nutritional issues in AIDS. 4:00 4:15

When is u p p e r e n d o s c o p y i n d i c a t e d ? Loren A. Laine. Los Angeles, CA Colorectal disease i n AIDS: How to find it. H o w to f i n d it. C. Melvin Wilcox. Birmingham, AL What will be found. Lawrence J. Brandt. Bronx, NY

4:30

Liver b i o p s y i n AIDS. Do it! Douglas T. Dieterich. Garden City, NJ Don't do it! Scott L. Friedman. New York, NY

4:45

N u t r i t i o n i n AIDS. PEG, PEJ, or n o t h i n g . Mark H. Delegge. Charlotte, NC

5:00

Discussion.

ASGE Poster Session

8:00 am-5:00 p m

Hall D Ernest N. Morial Convention Center

Authors are required to present during the Poster Session from 12:00-2:30 pm

Those posters identified as DDW Posters of Distinction have received review scores that place them within the top 10% of all posters. We encourage you to make them a priority as you visit the poster session. ENDOSCOPIC TECHNOLOGY: S P E C I A L IMAGING, RESECTION AND MUCOSECTOMY A r g o n p l a s m a c o a g u l a t i o n i n the t r e a t m e n t of r e s i d u a l a d e n o m a t o u s tissue after polypectomy. (Abstract# E0048) J Regula, E Wroriska, A Nasierowska, M Polkowski, J Pachlewski and E Butruk. Warsaw, Poland "Suck-and-cut" m u c o s e c t o m y of e a r l y esophageal a n d gastric cancer. (Abstract# E0040) A May, L Gossner, E Gfinter, G Mayer, R Henrich, M Stolte and C Ell. Wiesbaden and Bayreuth, Germany Endoscopic resection of l a t e r a l l y s p r e a d i n g t u m o r s of the large i n t e s t i n e u s i n g distal a t t a c h m e n t . (Abstract# E0073) H Yoshikane, H Hidan0, A Sakakibara, T Ayakawa, N Taki, S M0ri, Y Takahashi, Y Niwa and H Goto. Aichi, Japan Endoscopic mucosal r e s e c t i o n u s i n g n e e d l e knife. (Abstract# E0029) H-Y Jung, GH Kang, S-K Yang, W-S Hong and YI Min. Seoul, Korea E v a l u a t i o n of colonic p o l y p e c t o m y of large elevated lesion u s i n g d e t a c h a b l e s n a r e p r o c e d u r e . (Abstract# E0041) H Miki, N Yoshikawa, Y Akita, K Kaneko and K Mitamura. Tokyo, Japan High r e s o l u t i o n e n d o s o n o g r a p h y p r i o r to endoscopic m u c o s a l resection i n p a t i e n t s w i t h s u p e r f i c i a l c a r c i n o m a s of the esophagus a n d stomach. (Abstract# E0022) E G~inter, L Gossner, A May, G Mayer, R Henrich and C Ell. Wiesbaden, Germany

A p r i l 1998

P R O G R A M OF T H E ANNUAL M E E T I N G P I I 5

A S G E P O S T E R S E S S I O N n T U E S D A Y , M A Y 19, 1998 E n d o s c o p i c m i n i a t u r e u l t r a s o u n d - a s s i s t e d endoscopic a s p i r a t i o n mucosectomy: a n e w t e c h n i q u e for r e s e c t i o n of gastric m u c o s a l lesions a n d s u b m u c o s a l tumors. (Abstract# E0013) JY Cho, SJ Hong, JH Moon, YD Cho, JH Kim, JS Lee, YS Kim, MS Lee, SG Hwang and CS Shim. Seoul, Korea

DDW Poster of Distinction:

Clinical o u t c o m e of endoscopic m u c o s a l r e s e c t i o n for superficial g a s t r o i n t e s t i n a l lesions a n d the role of high f r e q u e n c y u l t r a s o u n d p r o b e sonography. (Abstract# E0069) I Waxman. Boston, MA

T e m p o r a r y p l a c e m e n t of m e t a l l i c s t e n t s for b e n i g n g a s t r o i n t e s t i n a l s t r i c t u r e s a n d fistulae. (Abstract# E0036) SK L0. Torrance, CA

C o m p a r i s o n of f l u o r e s c e n t s p e c t r a b e t w e e n n o r m a l m u c o s a a n d gastric a d e n o c a r c i n o m a s u n d e r a real t i m e d a u t o f l u o r e s c e n c e endoscopy. (Abstract# E0045) A NamLhisa, H Watanabe, T Ogihara, 0 K0bayashi, R Iwazaki, R Ohkura, H Miwa and N Sato. Tokyo, Japan Real-time diagnosis of superficial type early colorectal c a n c e r s u s i n g a n a u t o f l u o r e s c e n c e endoscopic system. (Abstract# E0068) H Watanabe, T Ogihara, A Namihisa, Y Ono, O Kobayashi, T Terai, H Miwa and N Sato. Tokyo, Japan Use of endoscopic a u t o f l u o r e s c e n c e i m a g i n g i n d i a g n o s i s of disease of the esophagus a n d stomach. (Abstract# E0070) AA Weiss, H Zeng, RW Kline, C MacAuley and N Mackinnon. Vancouver and Richmond, Canada H o w c a n we avoid the r i s k of p e r f o r a t i o n ? Our

Endoscopic t r e a t m e n t of gastric v a r i c e s with N-butyl-2cyanoacrylate: a l o n g t e r m follow-up. (Abstract# E0007) P Billi, GL Milandri, D Borioni, C Fabbri, D Baroncini, V Cennamo, A Piemontese and N D'Imperio. Bologna, Italy

Long t e r m o u t c o m e of s t e n t i n s e r t i o n for i n t e s t i n a l s t r i c t u r e s i n C r o h n ' s disease. (Abstract# E0039) N Matsuhashi, A Nakajima, A Suzuki and Y Yazaki. Tokyo, Japan Endoscopic plastic s t e n t r e m o v a l u s i n g a n angled snare. (Abstract# E0026) KY Ho, H M0ntes, MJ Sossenheimer, F Ruymann, J Van Dam and DL Cart-Locke. Boston, MA N e w p a n c r e a t o s c o p y for the n e x t g e n e r a t i o n -

d e v e l o p m e n t of p e r o r a l electronic p a n c r e a t o s c o p e system. (Abstract# E0054) H Sato, T K0dama, Y Tatsumi, Y H0rii, H Uehira, Y Imamura, K Kato, T K0shitani, Y Yamane and K Kashima. Kyoto, Japan Use of a double c h a n n e l d u o d e n o s c o p e for diagnostic a n d t h e r a p e u t i c ERCP. (Abstract# E0034) RA Kozarek and SL Raltz. Seattle, WA

e x p e r i e n c e of 275 cases of m u c o s e c t o m y for e n t i r e GI t r a c t lesions. (Abstract# E0180) H Inoue, M Tani, M Tada, K Nagai, T Kawano and K Takeshita. Tokyo, Japan

U l t r a - t h i n p a n c r e a t o s c o p y : is it r e a l l y useful for the diagnosis of p a n c r e a t i c diseases? (Abstract# E0043) YS Moon, JH Kim, BM Yoo and SW Cho. Suwon and Seoul, Korea

DDW Poster of Distinction:

Endoscopic n a s o - g a l l b l a d d e r d r a i n a g e b y p r e s h a p e d cystic duct c a n n u l a t i o n c a t h e t e r i n g a l l b l a d d e r diseases. (Abstract# E0042) YS Moon, JH Kim, BM Yoo and SW Cho. Suwon and Seoul, Korea

F u l l t h i c k n e s s excision biopsy at flexible endoscopy w i t h s t i t c h e d w o u n d closure: a n e x p e r i m e n t a l study. (Abstract# E0262) S Okuwaki, H Suzuki, F Gong and P Swain. Tokyo, Japan and London, United Kingdom Gastric endoscopic m u c o s e c t o m y - a n e x p e r i m e n t a l c o m p a r a t i v e s t u d y of five different techniques. (Abstract# E0233) MA D'Assun~o, K Hashiba, AM Wada, WR Freitas, D Moribe, S Armellini and KRM Leite. Sao Paulo, Brazil E N D O S C O P I C TECHNOLOGY: STENTS, U L T R A T H I N AND OTHER ENDOSCOPIC TECHNOLOGY New '~nultiple g n i d e w i r e m e t h o d " for endoscopic p l a c e m e n t of m u l t i p l e b i l i a r y stents. (Abstract# E0032) JH Kim, BM Yoo, YJ Shin, KB Hahm and SW Cho. Suwon, Korea A n e l e c t r o n microscopic s t u d y o n b i l i a r y s t e n t m a t e r i a l s . (Abstract# E0067) AM van Berkel, J van Marle, H van Veen, AK Gr0en and K Huibregtse. Amsterdam, The Netherlands Non-fluoroscopic p l a c e m e n t of m e t a l stents i n m a l i g n a n t esophageal o b s t r u c t i o n . (Abstract# E0005) N Bethge and N Vakil. Berlin, Germany and Milwaukee, WI Self-expanding m e t a l s t e n t s for endoscopic t r e a t m e n t of the esophageal achalasia. (Abstract# E0015) GD De Palma, L Sivero, G Galloro, S Sicilano and C Catanzano. Naples, Italy

T r a n s n a s a l endoscopy for f e e d i n g t u b e p l a c e m e n t i n critically ill p a t i e n t s . (Abstract# E0017) J Dranoff, P Angood and M Topazian. New Haven, CT Small caliber e s o p h a g o g a s t r o d u o d e n o s c o p y w i t h o u t sedation: a prospective s t u d y of h e a l t h y volunteers. (Abstract# E0062) D Sorbi, CJ Gostout, T Pasha and KD Lindor. Rochester, MN Endoscopic c l o s u r e of small g a s t r o i n t e s t i n a l p e r f o r a t i o n s u s i n g endoclips. (Abstract# E0027) JH Hyun, HJ Chun, YT Jeen, SJ Lee, KH Kim, HJ Park, SH Urn, SW Lee, JH Choi, CD Kim and HS Ryu. Seoul, Korea Depth of colon biopsies u s i n g a n e w biopsy forceps. (Abstract# E0038) MH Mantel, RD Odze, J Vandervoort, J Wolf, MJ Sossenheimer, H Montes, KY Ho and DL Carr-Locke. Boston, MA U l t r a s o n i c tactile sensor: the p o t e n t i a l for e v a l u a t i n g d e p t h of i n v a s i o n i n s q u a m o u s cell carcinoma. (Abstract# E0072) T Yoshida and H Inoue. Tokyo, Japan P h o t o d y n a m i c t h e r a p y t a r g e t e d to t h e p r o x i m a l d u o d e n u m i n familial a d e n o m a t o u s polyposis. (Abstract# E0055) JC Saurin, T Ponchon, F Descos, C Partensky and R Lambert. Lyon, France

Pl16 PROGRAMOF THE ANNUAL:MEETING

T e s t i n g of t h e m i n i m u m s t a n d a r d t e r m i n o l o g y in t h e U n i t e d States. (Abstract# E00U) OW Cass, LY Korman, W Brugge, W Harford, I Robertsand the MST Testing Project. Minneapolis, MN and Washington, DC Quantitative endoscopy using a novel computerized i m a g e p r o c e s s i n g s y s t e m . (Abstract# E0035) R Ligresti, CJ Lightdale, PD Stevens, RJ GarciaCarrasquillo and J Finegold. New York, NY The p o t e n t i a l r o l e of t e l e m e d i c i n e i n t h e r a p e u t i c e n d o s c o p y . (Abstract# E0003) A Ahmed, P Prasad, E Slosberg and J Imperial. Stanford, CA

GASTROENTEROLOGYVol. 114~No. 4

Does p r e - t r e a t m e n t w i t h s u b l i n g u a l h y o s c y a m i n e m a k e ERCP q u i c k e r a n d c h e a p e r ? (Abstract# E0355) AT Duong, L J Stone and DL Diehl. Sylmar, CA Clinical o u t c o m e s a n d p r e d i c t o r s of r e s p o n s e a f t e r e n d o s c o p i c t r e a t m e n t for s p h i n c t e r of O d d i dysfunction. (Abstract# E0427) H Tang, PR Tarnasky, KG Yeoh, JT Cunningham, DA Devonshire, AV Sahai, WL Knapple, E Rawls, PB Cotton and RH Hawes. Charleston, SC

DDW Poster of Distinction:

Outcomes of e n d o s c o p i c t h e r a p y f o r choledochol i t h i a s i s (CBDS) i n a t e r t i a r y c a r e c e n t e r . (Abstract# E0397) H Montes, KY Ho, MJ Sossenheimer, J Vandervoort, R Soetikno, J Van Dam, F Ruymann and DL Carr-Locke. Boston, MA

E n d o s c o p i c l i g a t i o n of b l e e d i n g i n t e r n a l h e m o r r h o i d s u s i n g m u l t i b a n d H g a t i o n device. (Abstract# E0057) AK Sethi, WH S0bin and M Garretto. Kenosha, WI

P r o s p e c t i v e c o m p a r i s o n of c o m p l i c a t i o n s of d i a g n o s t i c a n d t h e r a p e u t i c E R C P in a s i n g l e center. (Abstract#

Efficacy a n d s a f e t y of e n d o s c o p i c r e t r o g r a d e l i g a t i o n of b l e e d i n g i n t e r n a l h e m o r r h o i d s . (Abstract# E0066) EA Tr0wers, U Ganga, R Rizk, E Ojo and D H0dges. Lubbock, TX PEDIATRIC ENDOSCOPY H e p a t o b i l i a r y a n d p a n c r e a t i c d i s e a s e i n cystic fibrosis: ERCP f i n d i n g s a n d o u t c o m e of t h e r a p y . (Abstract# E0443) CP Choudari, GA Lehman, S Sherman, EL F0gel, WB Silverman, MF Catalano, JE Geenen, K Block and MJ Schmalz. Indianapolis, IN H e r e d i t a r y p a n c r e a t i t i s : c l i n i c a l c h a r a c t e r i s t i c s , ERCP f i n d i n g s a n d o u t c o m e of e n d o s c o p i c t h e r a p y a n d s u r g e r y . (Abstract# E0444) CP Choudari, NJ Nickl, EL Fogel, S Sherman and GA Lehman. Indianapolis, IN and Lexington, KY R e s u l t s a n d c o m p l i c a t i o n s of e n d o s c o p y i n p e d i a t r i c b o n e m a r r o w t r a n s p l a n t r e c i p i e n t s . (Abstract# E0156) MT Rivera, SL Werlin, CW Brown and JP Balint. Milwaukee, WI D i r e c t a n d i n d i r e c t costs of e n d o s c o p y v a r y b y site of service: h o s p i t a l - b a s e d e n d o s c o p y suite, o p e r a t i n g r o o m , a n d a m b u l a t o r y s u r g e r y center. (Abstract# E0154) LA Heitlinger, D Rehm, M Justice and G Roberts. Columbus, OH E R C P - - BILIARY: T R A I N I N G , S A F E T Y AND OUTCOMES L e a r n i n g c u r v e for p r e c u t b i l i a r y s p h i n c t e r o t o m y . (Abstract# E0337) TH Baron, WJ Geels and G Heudebert. Birmingham, AL

E0398) H Montes, MJ Sossenheimer, KY Ho, J Vandervoort, R Soetikno, J Van Dam, F Ruymann and DL Carr-Locke. Boston, MA Do d u o d e n a l d i v e r t i c u l a m a k e E R C P a m o r e difficult a n d c o m p l i c a t e d p r o c e d u r e ? (Abstract# E0396) H Montes, KY Ho, MJ Sossenheimer, J Vandervoort, J Van Dam, F Ruymann and D Carr-Locke. Boston, MA Outcome of p a t i e n t s w i t h i n t a c t g a l l b l a d d e r a f t e r e n d o s c o p i c t r e a t m e n t of c o m m o n b i l e d u c t stones. (Abstract# E0335) E Alcocer, MF Catalano and S Meyerson. Milwaukee, WI R i s k factors for b l e e d i n g a f t e r e n d o s c o p i c s p h i n c t e r o t o m y . (Abstract# E0413) T Rabenstein, C Ell, HT Schneider and EG Hahn. Erlangen and Wiesbaden, Germany Clinical s i g n i f i c a n c e of r i s k f a c t o r a n a l y s i s f o r c o m p l i c a t i o n s of e n d o s c o p i c s p h i n c t e r o t o m y . (Abstract# E04U) T Rabenstein, C Ell, HT Schneider and EG Hahn. Erlangen and Wiesbaden, Germany Cost effective m a n a g e m e n t of p a t i e n t s w i t h s u s p e c t e d b i l i a r y o b s t r u c t i o n . (Abstract# E0353) KZ Darwish, AP Manocha and BL Bleau. Cincinnati, OH Clinical s i g n i f i c a n c e of bile b a c t e r i a a n d b a c t e r e m i a r e l a t e d to ERCP. (Abstract# E0340) JM Bordas, J Mensa, Almela, J Llach, A Gin,s, F Mondelo, JM Pique and J Ter~s. Barcelona, Spain The effect of p r o p o f o l a n d n a r c o t i c on t h e c o m m o n b i l e duct, s p h i n c t e r of Oddi a n d t h e p a n c r e a t i c duct. (Abstract# E0435) MS Zua, TL Abell, R Werkman and W Bagous. Memphis, TN

Endoscopic retrograde cholangiopancreatography w i t h o u t g l u c a g o n c a n b e successful a n d cost effective. (Abstract# E0388) P Malik, RD Brown, B Pastika, B Kirsh, G D0dda and RP Venu. Chicago, IL

Does t h e o b s e r v a t i o n of " p s e u d o m i c r o l i t h i a s i s " i n ERCP c o n t r a s t a g e n t s affect t h e f i n a l o u t c o m e of b i l e a n a l y s i s in p a t i e n t s w i t h s u s p e c t e d m i c r o l i t h i a s i s ? (Abstract# E0404) VK Parasher, K Romain and R Sukumar. Lewes, DE

C o m p l i c a t i o n s of E R C P i n p a t i e n t s w i t h p r i m a r y s c l e r o s i n g c h o l a n g i t i s . (Abstract# E0357) R Enns, M Eloubeidi, K Mergener, MS Branch, PS Jowell and J Baillie. Durham, NC

E n d o s c o p i c t r e a t m e n t of p a t i e n t s w i t h p r i m a r y sclerosing cholangitis may improve survival: a long-term follow-up. (Abstract# E0374) GK Johnson, I Beblawi, JE Geenen, WJ Hogan, M Schmalzl M Catalan0, D Geenen and J Nelson. Milwaukee, WI

S a f e t y a n d efficacy of E R C P i n p r e g n a n c y . (Abstract# E0417) RH Seidel, JS Burdick, E Hernandez, M Goldschmiedt and DJ Magee. Dallas, TX

A m p u l l a r y a d e n o m a s : long t e r m r e s u l t s o f t h e e n d o s c o p i c t r e a t m e n t . (Abstract# E0346) A Chavaillon, T Ponchon, F Berger, JC Saurin, F Descos, C Partensky and R Lambert. Lyon, France

April1998

PROGRAMOF THEANNUALMEETINGPl17

A S G E P O S T E R S E S S I O N - - T U E S D A Y , M A Y 19, 1998 I n i t i a l c a t h e t e r choice for selective bile duct c a n n u l a t i o n d u r i n g ERCP: a prospective r a n d o m i z e d s t u d y w i t h e m p h a s i s o n outcome. (Abstract# E0342) RD Brown, G Dodda, B Pastika, R Bedford and RP Venu. Chicago, IL and Los Angeles, CA

P r e v e n t i o n of gallstone p a n c r e a t i t i s i n p a t i e n t s w i t h n o r m a l bile d u c t s u t i l i z i n g e n d o s c o p i c s p h i n c t e r o t o m y w i t h o u t cholecystectomy. (Abstract# E0362) MJ Gibbons, JSA Collins, RGP Watson and TCK Tham. Belfast, Northern Ireland

Is MRCP w o r t h w h i l e w h e n ERCP is p l a n n e d ? A p r o s p e c t i v e t r i a l i n a r e f e r r a l center. (Abstract# E0016) DA Devonshire, AV Sahai, KG Yeoh, C Kay, D Feldman, H Tang, P Tarnasky, J Cunningham, RH Hawes and PB Cotton. Charleston, SC

Gabexate i n the p r e v e n t i o n of post-ERCP p a n c r e a t i t i s : s h o u l d we be i n h i b i t e d b y the cost? (Abstract# E0336) KA Atkinson, SM Shulman, TP Ponich and JC Gregor. London, Canada

Post-sphincterotomy hemorrhage: management and outcome. (Abstract# E0260) ID Norton, BT Petersen, A Geller, RW Hughes, RK Balm, CJ Gostout and the GI Bleeding Team. Rochester, MN ERCP - - BILIARY: PANCREATITIS AND OTHER COMPLICATIONS F r e q u e n c y of a b n o r m a l s p h i n c t e r of Oddi m a n o m e t r y i n alcoholic p a n c r e a t i t i s . (Abstract# E0350) CP Choudari, EL Fogel, S Sherman and GA Lehman. Indianapolis, IN C o m m o n bile d u c t m i c r o l i t h i a s i s i n p a t i e n t s w i t h acute i d i o p a t h i c p a n c r e a t i t i s . (Abstract# E0383) M Kohut, A Nowak, TA Marek, E Nowakowska-Dulawa and R Kaczor. Katowice, Poland Changes i n p r e s e n c e a n d d e n s i t y of c o m m o n bile d u c t m i c r o l i t h i a s i s i n a c u t e b i l i a r y p a n c r e a t i t i s . (Abstract# E0402) A Nowak, M Kohut, E Nowakowska-Dulawa, R Kaczor and TA Marek. Katowice, Poland

D D W Poster of Distinction: P r o s p e c t i v e l o n g t e r m follow-up after acute b i l i a r y p a n c r e a t i t i s i n p a t i e n t s w i t h g a l l b l a d d e r stones left in situ. (Abstract# E0403) A Nowak, M Blaszczyflska, TA Marek, E NowakowskaDulawa and R Kaczor. Katowice, Poland E n d o s c o p i c p a n c r e a t i c s p h i n c t e r o t o m y for r e c u r r e n t a c u t e p a n c r e a t i t i s i n p a t i e n t s with s p h i n c t e r of Oddi d y s f u n c t i o n . (Abstract# E0361) D Gabbaizadeh, ES Siqueira, W Sflverman and A Slivka. Pittsburgh, PA Meta-analysis of r a n d o m i z e d , controlled trials of endoscopic r e t r o g r a d e c h o l a n g i o g r a p h y a n d endoscopic s p h i n c t e r o t o m y i n a c u t e p a n c r e a t i t i s due to gallstones. (Abstract# E0420) VK Sharma and CW Howden. Columbia, SC Risk factors of p a n c r e a t i t i s after endoscopic m a n o m e t r y for s u s p e c t e d s p h i n c t e r of Oddi d y s f u n c t i o n . A m u l t i v a r i a t e analysis. (Abstract# E0430) T Wehrmann, OG Wendler and WF Caspary. Frankfurt, Germany Risk factors for p a n c r e a t i t i s following s p h i n c t e r of Oddi m a n o m e t r y . (Abstract# E0369) KY Ho, H Montes, MJ Sossenheimer, F Ruymann, J Van Dam and DL Carr-Locke. Boston, MA Endoscopic p a p i l l a r y b a l l o o n d i l a t i o n for m u l t i p l e or large c o m m o n bile d u c t stones. ESWL m a y r e d u c e the r i s k of p a n c r e a t i t i s . (Abstract# E0433) I Yasuda, E Tomita and H Moriwaki. Gifu, Japan

Endoscopic m a n a g e m e n t of b i l i a r y c o m p l i c a t i o n s following o r t h o t o p i c liver t r a n s p l a n t a t i o n . (Abstract# E0375) WF Jones, R Kaikaus, L Deeb, M Coffey, C Tamburro, R Bentley, J Jones, S Mizrahi and M Heck. Louisville, KY ERCP - - BILIARY: S P H I N C T E R OF ODDI DISORDERS, STRICTURE AND S T E N T S

D D W Poster of Distinction: In vitro s t u d y of b a c t e r i a l a t t a c h m e n t to b i l i a r y s t e n t materials. (Abstract# E0390) M Matzen, Y Tian, P DeFazio, W Knapple, P Tarnasky and P Cotton. Clemson and Charleston, SC Long t e r m outcomes i n p a t i e n t s w i t h b e n i g n b i l i a r y s t r i c t u r e t r e a t e d endoscopically w i t h m u l t i p l e stents. (Abstract# E0351) JT Cunningham, PV Draganov, E Rawls, BJ Hoffman, WH Marsh and PB Cotton. Charleston, SC Q u a n t i t a t i v e c h o l e s c i n t i g r a p h i c e v a l u a t i o n o n the f u n c t i o n of s p h i n c t e r of Oddi after p a p i l l a r y b a l l o o n dilation. (Abstract# E0373) H Isayama, Y Komatsu, K Tateishi, M Yamagata, M Tada, H Yoshida, Y Shiratori, T Kawabe and M Omata. Tokyo, Japan Endoscopic t h e r a p y of type II s p h i n c t e r of Oddi d y s f u n c t i o n w i t h o u t m a n o m e t r y . (Abstract# E0372) DA Howell, BL Hanson, PM Ku and E Elton. Portland, ME S p h i n c t e r of Oddi d y s f u n c t i o n : m a n a g e m e n t of nonr e s p o n d e r s to endoscopic s p h i n c t e r o t o m y . (Abstract# E0410) W Qureshi. Little Rock, AR I n c i d e n c e of s p h i n c t e r of Oddi d y s f u n c t i o n i n p a t i e n t s w i t h p a n c r e a s divistun. (Abstract# E0359) E Fogel, CP Choudari, LG Bucksot, J Flueckiger, S Sherman and GA Lehman. Indianapolis, IN HIV-related c h o l a n g i o p a t h y : is endoscopic b i l i a r y s p h i n c t e r o t o m y a n effective t h e r a p y ? (Abstract# E0431) AR Wettstein, G Dore, C Murphy and PD Edwards. Sydney, Australia The s p h i n c t e r of Oddi is n o t m a n o m e t r i c a l l y symmetrical. (Abstract# E0407) RS Patel, JT Cunningham, PB Cotton and RH Hawes. Charleston, SC Endoscopic t h e r a p y for stenosis of t h e b i l i a r y a n d p a n c r e a t i c d u c t orifices. (Abstract# E0380) S Khandekar, JA DiSario and DJ Bjorkman. Salt Lake City, UT Clinical s t u d y c o m p a r i n g outcomes of different NKS techniques. (Abstract# E0406) JJ Park, SS Kim, HS Yoon, YK Kim, DH Kang, DJ Choi, HC Park and JH Kim. Inchon, Korea

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A S G E P O S T E R S E S S I O N - - T U E S D A Y , M A Y 19, 1 9 9 8 C a n b i l i a r y s t e n t i n g be a n a l t e r n a t i v e to endoscopic n a s o b i l i a r y d r a i n a g e i n p a t i e n t s w i t h acute s u p p u r a t i v e c h o l a n g i t i s ? (Abstract# E0405) JJ Park, SS Kim, YK Kim, DH Kang, DJ Ch0i, HC Park and JH Kim. Inch0n, Korea

Endoscopic treatment of common bile duct stones improves the clinical course in primary sclerosing

Short t e r m e n d o b i l i a r y s t e n t i n g r e s u l t s i n c h r o n i c i n f l a m m a t i o n of the p o r c i n e e x t r a h e p a t i c b i l i a r y system. (Abstract# E0354) BJ Dunkin, JM Marks, J Singh, RH Lash and JL Ponsky. Cleveland, OH

P r e o p e r a t i v e EUS versus i n t r a o p e r a t i v e c h o l a n g i o g r a m i n p a t i e n t s w i t h suspected c o m m o n bile d u c t stones: a prospective r a n d o m i z e d trial. (Abstract# E0416) V Sarabanchong, PD Stevens, J Finegold, PHR Green, M Bessler, J Chab0t and CJ Lightdale. New York, NY

Do p a t i e n t s w i t h s p h i n c t e r of Oddi d y s f u n c t i o n h a v e g r e a t e r analgesic r e q u i r e m e n t following s p h i n c t e r of Oddi m a n o m e t r y ? (Abstract# E0367) KY Ho, H Montes, MJ Sossenheimer, F Ruymann, J Van Dam and DL Carr-Locke. Boston, MA

C o m p a r i s o n of endoscopic s p h i n c t e r o t o m y a n d p e r c u t a n e o u s t r a n s h e p a t i c cholangioscopy for the t r e a t m e n t of c o m m o n bile d u c t stones. (Abstract#

ERCP - - BILIARY: C H O L E L I T H I A S I S AND OTHER STONE DISEASES F i r s t clinical d a t a o n laser l i t h o t r i p s y of c o m m o n bile d u c t stones w i t h a n e w F r e q u e n c y - D o u b l e d DoubleP u l s e Nd:YAG l a s e r (FREDDY). (Abstract# E0371) J Hochberger, J Bayer, J Maiss, S Tex, R Stein, J Tschepe and EG Hahn. Erlangen and Germany, Germany Prospective r a n d o m i z e d t r i a l of endoscopic b a l l o o n d i l a t i o n v e r s u s s p h i n c t e r o t o m y for e x t r a c t i o n of bile d u c t stones. (Abstract# E0347) YK Chen, L Deguzman, A Godil, KJ Chang, RA Erickson and MH Walter. Loma Linda, San Bernardino and Irvine, CA; Temple, TX Endoscopic p a p i l l a r y b a l l o o n d i l a t a t i o n v e r s u s endoscopic s p h i n c t e r o t o m y for r e m o v a l of c o m m o n bile duct stones. (Abstract# E0349) YD Cho, SJ Hong, JH Moon, JO Kim, JY Cho, YS Kim, JS Lee, MS Lee, SG Hwang and CS Shim. Seoul, Korea Clinical u s e f u l n e s s of i n t r a d u c t a l u l t r a s o n o g r a p h y o n d e t e c t i o n of small r e m n a n t stones after endoscopic p a p i l l a r y b a l l o o n d i l a t a t i o n . (Abstract# E0348) YD Cho, SJ Hong, JH Moon, JO Kim, JY Cho, YS Kim, JS Lee, MS Lee, SG Hwang and CS Shim. Seoul, Korea Needle knife f i s t u l o t o m y v e r s u s needle knife p r e c u t p a p i l l o t o m y for t h e t r e a t m e n t of c o m m o n bile duct stones. (Abstract# E0391) C Mavrogiannis, C Liatsos, A Romanos, C Petoumenos, A Nakos and G Karvountzis. Athens, Greece P r e o p e r a t i v e ERCP t e s t e d b y i n t r a o p e r a t i v e cholangiography: the case for one-stage laparoscopic c o m m o n bile d u c t clearance. (Abstract# E0356) MB Edye, J Endres, F Gattorn0 and B Salky. New York, NY Endoscopic p a p i l l a r y b a l l o o n d i l a t i o n u s i n g a long tip balloon catheter for the management

of common bile

d u c t stone. (Abstract# E0384) Y Komatsu, T Kawabe, T Ijichi, H Isayama, M Yamagata, M Tada, Y Shiratori and M Omata. Tokyo, Japan Successful e x t r a c t i o n of l a r g e c o m m o n bile duct stones i n the s e t t i n g of Billroth-II g a s t r o e n t e r o s t o m y . (Abstract# E0345) MF Catalano, E Alcocer, S Lahoti, GK Johnson, DJ Geenen, JB Nelson, JE Geenen and WJ Hogan. Milwaukee, WI Discrimination between primary and secondary choledocholithiasis b y endoscopic u l t r a s o n o g r a p h y . : (Abstract# E0432) M Yamagata, Y Komatsu, K Tateishi, H Isayama, M Ohashi, N Toda, M Tada, H Yoshida, T Kawabe, Y Shiratori and M Omata. Tokyo, Japan

cholangitis p a t i e n t s . (Abstract# E0339) IE Beblawi, SM Meyerson, JE Geenen, MF Catalano, MJ Schmalz, D Geenen and WJ Hogan. Milwaukee, WI

E0395)

L-R Mo, M-H Huang and S-K Yuh. Tainan, Taiwan Is the cholangioscopic complete r e m o v a l of i n t r a hepatic duct stones affected b y the sites of b i l i a r y strictures? (Abstract# E0400) JH Moon, YD Cho, SJ Hong, JO Kim, JY Cho, YS Kim, JS Lee, MS Lee, SG Hwang and CS Shim. Seoul, Korea P e r c u t a n e o u s t r a n s h e p a t i c cholangioscopic t r e a t m e n t for hepatolithiasis: long t e r m results. (Abstract# E0386) SK Lee, MH Kim, DW Seo, SJ Myung, HJ Kim, SW Nam, YS Kim, SJ Bang, YR Park, SY Kim, SY Yang, KN Shin, YI Min, KB Sung and SG Lee. Seoul, Korea I n t r a h e p a t i c lithiasis: s h o r t a n d long t e r m r e s u l t s of p e r c u t a n e o u s t r e a t m e n t . (Abstract# E0409) T Ponchon, PJ Valette, R Bory, L Henry, B Napoleon, F Hedelius and C Partensky. Lyon, France ERCP - - MALIGNANT STRICTURE, CANCER, AND OTHER BILIARY ERCP

DDW Poster of Distinction: Diagnosing c h o l a n g i o c a r c i n o m a i n p r i m a r y sclerosing cholangitis: t h e role of b r u s h cytology a n d s e r u m t u m o r markers. (Abstract# E0423) ES Siqueira, RE Schoen, V Balan, WB Silverman, M Rabinovitz, JA Martin, K Abu-E1Magd, J Madariaga, J Rakela and A Slivka. Pittsburgh, PA The usefulness of p r e o p e r a t i v e cholangioscopy i n p a t i e n t s w i t h Klatskin's t u m o r . (Abstract# E 0 4 1 9 ) DW Seo, YS Kim, HJ Kim, SJ Myung, JS Kim, SK Lee, MH Kim, KM Park, YJ Lee, SG Lee and YI Min. Seoul, Korea The usefulness of cholangioscopy i n the d i a g n o s i s of early bile d u c t c a n c e r i n p a t i e n t s w i t h focal s t r i c t u r e of i n t r a h e p a t i c duct. (Abstract# E0418) DW Seo, YS Kim, HJ Kim, SJ Myung, JS Kim, SK Lee, MH KIm and YI Min. Seoul, Korea Clinical e v a l u a t i o n of covered metallic s t e n t s for p a l l i a t i n g m a l i g n a n t b i l i a r y strictures. (Abstract# E0378) Y Kawase, N Ikehara, H Sumi, T Suzuki, Y Yamashiro, T Yamasaki, H Kitamura, M Fukuda and Y Kojima. Hyogo, Japan Does the r e s p o n s e to plastic s t e n t s p r e d i c t t h a t of Wallstent i n the t r e a t m e n t of m a l i g n a n t b i l i a r y o b s t r u c t i o n ? (Abstract# E0414) I Raijman, V Amin, I Siddique, J Linder and P Lynch. Houston, TX

April 1998

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E v a l u a t i o n of n e w p l a s t i c s t e n t (double-layer stent) for i n o p e r a b l e m a l i g n a n t b i l i a r y o b s t r u c t i o n . (Abstract# E0428) K Uno, M Nakajima, K Yasuda, H Mukai and T Hayakumo. Kyoto and Osaka, Japan

Clinical e v a l u a t i o n o f e n d o s c o p i c b i l i a r y s t e n t i n g in patients with benign distal common bile duct stricture d u e to c h r o n i c p a n c r e a t i t i s . ( A b s t r a c t # E0440) YD Cho, SJ Hong, JH Moon, JO Kim, JY Cho, YS Kim, JS Lee, MS Lee, SG Hwang and CS Shim. Seoul, Korea

O u t p a t i e n t t h e r a p e u t i c ERCP w i t h e n d o b i l i a r y s t e n t p l a c e m e n t for m a l i g n a n t c o m m o n b i l e d u c t o b s t r u c t i o n . (Abstract# E0352) B Cvetkovski, H Gerdes and RC Kurtz. New York, NY

DDW Poster of Distinction:

High dose rate intraluminal brachytherapy in m a l i g n a n t b i l i a r y o b s t r u c t i o n . A s e r i e s of t e n cases. (Abstract# E0343) J Buhac, S Chow, RCM Lo, FW Heiss, JA Shea and J J Bosco. Burlington, MA The r o l e of e h o l e d o c h o s c o p y i n t h e d i a g n o s i s a n d m a n a g e m e n t of b i l i a r y disease: e x p e r i e n c e i n 55 p a t i e n t s . (Abstract# E0422) I Siddique, J Galati, V Ankoma-Sey, R Ghalib, RP Wood, C Ozaki and I Raijman. Houston, TX C h o l a n g i o s c o p y w i t h m e t h y l e n e b l u e s t a i n a n d p53 i m m u n o h i s t o c h e m i c a l s t a i n i n b i l i a r y disease. ( A b s t r a c t # E0421) CS Shim, SJ Hong, JH Moon, YD Cho, JH Kim, JY Cho, JS Lee, YS Kim, MS Lee, SG Hwang and CS Shim. Seoul, Korea

A l p h a - l - a n t i t r y p s i n a n d p o s t - E R C P p a n c r e a t i t i s : final r e s u l t s . (Abstract# E0450) K Gottlieb, S Sherman, E Fogel, C Choudari and G Lehman. Indianapolis, IN P r e - p r o c e d u r e a c u t e p h a s e p r o t e i n r e s p o n s e to t e t a n u s t o x o i d v a c c i n a t i o n : p o t e n t i a l r o l e f o r r e d u c t i o n of postERCP p a n c r e a t i t i s - a final a n a l y s i s . (Abstract# E0447) E Fogel, K Gottlieb, J Flueckiger, S Sherman and G Lehman. Indianapolis, IN S p o n t a n e o u s d i s l o d g e m e n t of u n f l a n g e d p a n c r e a t i c d u c t stents: a f i n a l a n a l y s i s . ( A b s t r a c t # E0448) E Fogel, S Sherman, K Gottlieb, M Olssen and G Lehman. Indianapolis, IN A c c e s s o r y p a n c r e a t i c d u c t d r a i n a g e does n o t p r o t e c t a g a i n s t E R C P - i n d u c e d p a n c r e a t i t i s . (Abstract# E0439) YK Chen, A Godil, MH Walter, SA Khan, RC Schilling and RL Foliente. Loma Linda, CA

N e e d l e k n i f e s p h i n c t e r o t o m y . A safe a n d effective p r o c e d u r e for b i l i a r y access. (Abstract# E0333) D Abi-Hanna, I Valiozis, M Bourke and SJ Williams. Sydney, Australia

Twenty-four-hour serum amylase predicting pancreatic reaction after endoscopic biliary sphincterotomy. (Abstract# E0467) PA Testoni, S Caporuscio, F Lella, F Bagnolo, E Colombo and U Bonassi. Milan and Zingonia, Italy

Endoscopic retrograde cholangiopancreatography and p y o g e n i c l i v e r abscesses. (Abstract# E0385) YH Lain, JYW Lau, KH Wong, ACW Chan, JJY Sung and SCS Chung. Shatin, Hong Kong

M u l t i p l e p a n c r e a t i c i n j e c t i o n is a r i s k f a c t o r for postE R C P p a n c r e a t i t i s . (Abstract# E0461) H Montes, KY Ho, M Sossenheimer, J Vandervoort, J Van Dam, F Ruymann and DL Carr-Locke. Boston, MA

Clinical features and endoscopic appearance may p r e d i c t e a s e of d e e p bile d u c t c a n n u l a t i o n a t ERCP. (Abstract# E0341) RD Brown, AG Halline, G Dodda, B Kirsh and RP Venu. Chicago, IL

The use of a l l o p u r i n o l as a n a n t i o x i d a n t in t h e p r e v e n t i o n of p o s t - E R C P p a n c r e a t i t i s . (Abstract# E0457) A Kulkarni, D Kossoff, N Khan, RM Agrawal and GJ Brodmerkel. Pittsburgh, PA

M u l t i p l e b i l i a r y p a p i l l o m a t o s i s : i t s clinical, ERCP a n d c h o l a n g i o s c o p i c findings. (Abstract# E0382) MH Kim, SJ Myung, SY Kim, HJ Kim, DW Seo, SK Lee, MH Kim and YI Min. Seoul, Korea

E n d o s c o p i c m a n a g e m e n t of p a n c r e a t i c p s e u d o c y s t b y EUS l o c a l i z a t i o n o f p u n c t u r e s i t e a n d b a l l o o n d i l a t a t i o n of fistulae. (Abstract# E0462) ID Norton, JE Clain, EP DiMagno, K Wang, BT Petersen and CJ Gostout. Rochester, MN

Endoscopic retrograde pancreatography after p a n c r e a t i c o j e j u n o s t o m y . (Abstract# E0392) K Mergener, KS Freed, EK Paulson, R Enns, PS Jowell, MS Branch, TN Pappas and J Baillie. Durham, NC E n d o s c o p i c b i l i a r y W a l l s t e n t for h i l a r lesions. Is o u t c o m e t h e s a m e as for e x t r a - h i l a r o b s t r u c t i o n ? (Abstract# E0368) KY Ho, MJ Sossenheimer, H Montes, F Ruymann, J Van Dam and DL Carr-Locke. Boston, MA ERCP -- PANCREAS B i o c h e m i c a l a n d m i c r o b i o l o g i c a l e v a l u a t i o n of p a n c r e a t i c f l u i d collections d u r i n g e n d o t h e r a p y . (Abstract# E0460) KE M6nkemiiller and TH Baron. Birmingham, AL A b s e n c e of a c c e s s o r y p a n c r e a t i c d u c t e m p t y i n g t h r o u g h t h e m i n o r a m p u l l a is a m a j o r r i s k f a c t o r for g a l l s t o n e p a n c r e a t i t i s . (Abstract# E0459) AS McIntosh, MD Snow, A Chinichian and FC Ramirez. Phoenix, AZ

E n d o s c o p i c d r a i n a g e of i n f e c t e d p a n c r e a t i t i s p s e u d o c y s t s in t h e a b s e n c e of n e c r o s i s . (Abstract# E0437) MF Catalano, E Alcocer, I Raijman, S Lahoti and JE Geenen. Milwaukee, WI and Houston, TX Palliative endoscopic therapy in patients with pancreatic cancer and obstruction of the pancreatic d u c t u s i n g p a n c r e a t i c stenting. ( A b s t r a c t # E0438) MF Catalano, E Alcocer, I Raijman, S Lahoti, WJ Hogan and JE Geenen. Milwaukee, WI and Houston, TX Pseudocyst issued from heterotopic duodenal pancreas: e n d o s c o p i c t r e a t m e n t . (Abstract# E0463) T Ponchon, B Napol6on, F H~delius and R Bory. Lyon, France Experience with accessory pancreatic duct endoscopic t h e r a p y in p a t i e n t s w i t h o u t p a n c r e a s divisum. (Abstract# E0466) H Tang, PR Tarnasky, JT Cunningham, RH Hawes and PB Cotton. Charleston, SC

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Endoscopic pancreatic duct sphincterotomy: indications, complications and long term response to t h e r a p y . (Abstract# E0445) JC C0zart, C Prakash, MJ Bernstein, DT Walden and G Aliperti. St Louis, MO

Endoscopic u l t r a s o u n d a n d fine n e e d l e a s p i r a t i o n of u n e x p l a i n e d m e d i a s t i n a l l y m p h a d e n o p a t h y or masses. (Abstract# E0514) ID Penman, DB Williams, WL Knapple, G Mishra, AV Sahai, RH Hawes and BJ Hoffman. Charleston, SC

R o u t i n e b i l i a r y s p h i n c t e r o t o m y m a y n o t be i n d i s p e n s i b l e for endoscopic p a n c r e a t i c s p h i n c t e r o t o m y . (Abstract# E0455) MH Kim, SK Lee, SJ Myung, DW Seo, SY Kim, KN Shim, YS Kim, HJ Kim, JS Kim and YI Min. Seoul, Korea

Are t h e r e endoscopic u l t r a s o u n d c r i t e r i a t h a t r e l i a b l y i d e n t i f y m a l i g n a n t a d e n o p a t h y ? (Abstract# E0489) DO Faigel, GG Ginsberg, S Fanning and ML K0chman. Portland, OR and Philadelphia, PA

O b s t r u c t i n g p a n c r e a t i c d u c t stones: success a n d d e l a y e d c o m p l i c a t i o n s of endoscopic m a n a g e m e n t . (Abstract# E0451) BL Hanson, DA Howell, E Elt0n, T Qaseem, WG Parsons, JJ Bosco and S Broaddus. Portland, ME Balloon d i l a t i o n of p a n c r e a t i c s t r i c t u r e s for stone r e m o v a l is safe a n d i m p r o v e s successful endoscopic clearance. (Abstract# E0456) PM Ku, BL Hanson, E Elton and DA Howell. Portland, ME The modified Siegel s t e n t v e r s u s t h e modified G e e n e n stent; a s t u d y of s t e n t m i g r a t i o n a n d p a n c r e a t i c d u c t a l c h a n g e s with flapless p a n c r e a t i c stents. (Abstract# E0454) FE Kasmin, SA Cohen and JH Siegel. New York, NY E N D O S C O P I C ULTRASOUND: M E T H O D S AND U P P E R GI TRACT

E v a l u a t i o n of m e t a s t a t i c celiac axis l y m p h n o d e s i n p a t i e n t s w i t h esophageal c a r c i n o m a : a c c u r a c y of endoscopic u l t r a s o u n d . (Abstract# E0476) MF Catalano, E Alcocer, CC Nguyen, I Raijman, A Chak, JE Geenen, S Lahoti and MV Sivak. Milwaukee, WI; Atlanta, GA; Houston, TX and Cleveland, OH I m p a c t of EUS-gnided fine n e e d l e a s p i r a t i o n o n e v a l u a t i n g l y m p h nodes i n g a s t r o i n t e s t i n a l a n d l u n g cancer. (Abstract# E0529) W Wassef, N Fahmy, J Beets, J Stastny, K Willis and A Zfass. Richmond, VA

DDW Poster of Distinction: Endoscopic u l t r a s o u n d - d i r e c t e d t h e r a p y i m p r o v e s s u r v i v a l of p a t i e n t s with locoregionally a d v a n c e d esophageal cancer. (Abstract# E0534) G Zuccar0, TW Rice, JJ Vargo, JP Ciezki, JR Goldblum, LA Rybicki and DJ Adelstein. Cleveland, OH

E n d o s o n o g r a p h y - g n i d e d histologic n e e d l e biopsy. (Abstract# E0494) N Harada, M Arima and T Kouzu. Chiba, Japan

Does endoscopic u l t r a s o u n d - g u i d e d fine n e e d l e a s p i r a t i o n c h a n g e outcome i n p a t i e n t s w i t h esophageal cancer? (Abstract# E0523) RM Soetikno, P Nguyen, D Bastas and KJ Chang. Orange, CA

A r a n d o m i z e d d o u b l e - b l i n d placebo-controlled t r i a l e v a l u a t i n g t h e use of d r o p e r i d o l as a r o u t i n e p r e m e d i c a t i o n for endoscopic u l t r a s o u n d . (Abstract# E0517) J Rizzo, G Coyle, L Spitz, D Bernstein, J Tripodi and F Gress. Long Island, NY

P r e t r e a t m e n t EUS stage does n o t p r e d i c t complete response to n e o a d j u v a n t c h e m o r a d i a t i o n i n esophageal carcinoma. (Abstract# E0506) S Mallery, M DeCamp, R Bueno, S Mentzer, D Sugarbaker, S Swanson and J Van Dam. Boston, MA

EUS as a n aid to clinical decision m a k i n g i n suspected or p r o v e n cancers: a p r o s p e c t i v e s t u d y of its value to r e f e r r i n g p h y s i c i a n s . (Abstract# E0522) AV Sahai, I Penman, D Williams, G Mishra, W Knapple, A vanVelse, RH Hawes and BJ Hoffman. Charleston, SC

DDW Poster of Distinction: Endoscopic u l t r a s o u n d ( i n s t e a d of gastroscopy) m a y r e d u c e costs i n p a t i e n t s w i t h d y s p e p s i a and/or u n e x p l a i n e d u p p e r a b d o m i n a l p a i n . (Abstract# E0520) AV Sahai, I Penman, D Williams, W Knapple, G Mishra, A vanVelse, RH Hawes and BJ Hoffman. Charleston, SC A m u l t i c e n t e r U.S. e x p e r i e n c e w i t h EUS-guided fine n e e d l e a s p i r a t i o n u s i n g t h e O l y m p u s GF-UM30P echoendoscope a n d the O l y m p u s MAJ363 FNA needle system: safety a n d effectiveness. (Abstract# E0051) AV Sahai, D Schembre, P Stevens, G Isenberg, A Chak, CJ Lightdale, RH Hawes, MV Sivak and BJ Hoffman. Charleston, SC; Columbia, NY and Cleveland, OH

Clinical outcomes of T1 esophageal c a r c i n o m a as staged b y EUS: a m u l t i c e n t e r e v a l u a t i o n . (Abstract# E0502) S Mallery, G Zuccaro, D Ciaccia, WR Brugge, M Catalano, I Penman, B Hoffman, R Hawes, F Gress, G Isenberg, A Chak, T Rice and J Van Dam. Boston, MA; Cleveland, OH; Indianapolis, IN; Milwaukee, WI; Charleston, SC and Stony Brook, NY High-resolution endoscopic u l t r a s o n o g r a p h y w i t h m i n i a t u r e p r o b e i n achalasia. (Abstract# E0497) JO Kim, SJ Hong, JH Moon, YD Cho, JY Cho, YS Kim, JS Lee, MS Lee, SG Hwang and CS Shim. Seoul, Korea Endoscopic u l t r a s o n o g r a p h y i n achalasia: e c h o g r a p h i c a p p e a r a n c e a n d i n t e r e s t i n clinical practice. (Abstract# E0518) G Roseau, M Gaudric, I Dumontier, M Medrano, S Chaussade and D Couturier. Paris, France

Endoscopic u l t r a s o n o g r a p h y : n e e d for effort-based r e i m b u r s e m e n t . (Abstract# E0482) U Choudhry, M Acosta and HW Boyce. Tampa, FL

Simultaneous manometry and high resolution e n d o l u m i n a l s o n o g r a p h y of t h e lower esophageal s p h i n c t e r a n d the body of the esophagus i n n o r m a l volunteers. (Abstract# E0483) CY Chung, J-B Liu and LS Miller. Philadelphia, PA

Long t e r m follow-up of esophageal a n d p a n c r e a t i c c a n c e r staged b y EUS. (Abstract# E0525) BR Stotland, JD Lewis, GG Ginsberg, DB Smith and ML Kochman. Philadelphia, PA

Does EUS help i n the m a n a g e m e n t of u p p e r g a s t r o i n t e s t i n a l nodules? (Abstract# E0507) W Mayoral, X Cusso, JA Salcedo, PK Roy, D Bandres and TL Tio. Washington, DC

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3-D e n d o s c o p i c u l t r a s o n o g r a p h y i n lesions of t h e u p p e r GI t r a c t s . (Abstract# E0509) Y Murata, S Suzuki, Y Iizuka, A Mitunaga, H T0ki, M Uchiyama, H I d e and H Suzuki. Tokyo, Japan E n d o s o n o g r a p h i c f e a t u r e s p r e d i c t i v e of b e n i g n a n d malignant gastrointestinal smooth muscle tumors. (Abstract# E0513) L Palazzo, B Landi, C Cellier, E Cuillerier, I Dumontier, G Roseau and JP Barbier. Paris, France A c c u r a t e d i a g n o s i s of m y o g e n i c t u m o r s of t h e s t o m a c h b y e n d o s c o p i c u l t r a s o n o g r a p h y . (Abstract# E0532) J Y0shikawa, J Matsumote, K Suekawa, F Arimura, T Yamamoto and T Arima. Kag0shima, Japan E n d o s c o p i c u l t r a s o u n d - g u i d e d fine n e e d l e a s p i r a t i o n b i o p s y : a l a r g e single c e n t e r e x p e r i e n c e . (Abstract# E0071) DB Williams, AV Sahai, L Aabakken, I Penman, A vanVelse, RH Hawes and BJ Hoffman. Charleston, SC P r o s p e c t i v e e v a l u a t i o n of b a l l o o n s h e a t h for u l t r a s o u n d c a t h e t e r system. (Abstract# E0056) D Schembre, A Chak, P Stevensl C Lightdale, M Sivak, R Ligresti and G Eisenberg. New York, NY and Cleveland, OH

I n t e r o b s e r v e r a g r e e m e n t for c h r o n i c p a n c r e a t i t i s w i t h endoscopic ultrasonography. Preliminary results. (Abstract# E0473) P Burtin, M Barthet, L Buscail, L Palazzo, B Napoleon, D Heresbach, P L~vy, C Pilette, J Sahel, P Bernades, M Gosselin, V Vilgrain and J Boyer. Angers, Marseille, Toulouse, Paris, Lyon, Rennes and Clichy, France Can t h e p r e s e n c e of c h r o n i c p a n e r e a t i t i s d e t e c t e d b y e n d o s c o p i c u l t r a s o u n d p r e d i c t o u t c o m e in p a t i e n t s h a v i n g e n d o s c o p i c t h e r a p y f o r s p h i n c t e r of O d d i d y s f u n c t i o n ? (Abstract# E0498) WL Knapple, H Tang, KG Yeoh, AV Sahai, PR Tarnasky, BJ H0ffman and RH Hawes. Charleston, SC Role of e n d o s c o p i c u l t r a s o n o g r a p h y i n non-alcoholic p a n c r e a t i t i s . (Abstract# E0479) A Chak, RH Hawes, G Cooper, B Hoffman, MF Catalano, RCK Wong and MV Sivak, Jr. Cleveland, OH; Charleston, SC and Milwaukee, WI D i a g n o s t i c e v a l u a t i o n of p a t i e n t s w i t h i d i o p a t h i c r e c u r r e n t p a n c r e a t i t i s : r o l e of e n d o s c o p i c u l t r a s o n o g r a p h y . (Abstract# E0475) MF Catalano, E Alcocer, JE Geenen, S Lahoti and WJ Hogan. Milwaukee, WI

Is t h e r e a r o l e for e n d o s c o p i c u l t r a s o u n d in t h e s t a g i n g of CT-negative n o n - s m a l l cell l u n g c a r c i n o m a ? (Abstract# E0531) DB Williams, ID Penman, WL Knapple, C Reed, AV Sahai, RH Hawes and BJ Hoffman. Charleston, SC

P r o s p e c t i v e e v a l u a t i o n of e n d o s c o p i c u l t r a s o u n d g u i d e d fine n e e d l e a s p i r a t i o n f o r p a n c r e a t i c lesions. (Abstract# E0472) S Bourgeois, F Van de Mierop, M Hiele, P Schurmans, A Gevers, W Van Steenbergen and P Rutgeerts. Leuven, Belgium

A p p l i c a t i o n of i m a g e c o m p r e s s i o n to d i g i t i z e d g a s t r o i n t e s t i n a l e n d o s o n o g r a p h i c images: a p i l o t study. (Abstract# E0031) CY Kim, AV Sahai, WL Knapple, G Mishra, RH Hawes and BJ Hoffman. Charleston, SC

Clinical u t i l i t y of EUS a n d E U S - g u i d e d FNA i n s u b g r o u p s of p a t i e n t w i t h s u s p e c t e d p a n c r e a t i c m a l i g n a n c y . (Abstract# E0487) RA Erickson, B Perkins and A Avots-Avotins. Temple, TX

M i n i p r o b e e n d o s o n o g r a p h y c o m p a r e d to c o n v e n t i o n a l e n d o s o n o g r a p h y in p a t i e n t s w i t h s u p e r f i c i a l c a n c e r of t h e u p p e r GI t r a c t . (Abstract# E0023) E Giinter, L Gossner, A May, G Mayer, R Henrich and C Ell. Wiesbaden, Germany E N D O S C O P I C U L T R A S O U N D : BILIARY, PANCREAS, INTESTINE AND ABDOMEN I m p a c t of e n d o s c o p i c u l t r a s o u n d on t h e n e e d for ERCP in a r e f e r r a l c e n t e r p o p u l a t i o n . (Abstract# E0508) K Mergener, PS Jowell, R Enns, RC Nelson, CB Nardi, MS Branch and J Baillie. Durham, NC H e l i c a l CT c h o l a n g i o g r a p h y v e r s u s e n d o s o n o g r a p h y for s u s p e c t e d b i l e d u c t stones: a p r o s p e c t i v e , b l i n d e d s t u d y i n n o n - j a u n d i c e d p a t i e n t s . (Abstract# E0516) M Polkowski, J Palucki, J Regula, A Tilszer, J Dziukowa and E Butruk. Warsaw, Poland E n d o s o n o g r a p h y of l a r g e r e c t o s i g m o i d a d e n o m a s is n o t u s e f u l for p r e d i c t i n g p o s t p o l y p e c t o m y bleeding. (Abstract# E0515) M Polkowski, J Regula, E Wro~ska, J Pachlewski, M Rupifiski, A Nasierowska and E Butruk. Warsaw, Poland E n d o s c o p i c u l t r a s o n o g r a p h y is beneficial for t h e d e t e r m i n a t i o n of e x p a n s i o n of c a n c e r of t h e p a p i l l a of Vater. (Abstract# E0469) F Arimura, J Matumoto, J Yoshikawa, K Suekawa, T Yamamoto and T Arima. Kagoshima, Japan

D e t e r m i n a n t s of n u m b e r of fine n e e d l e a s p i r a t i o n p a s s e s in E U S - g u i d e d FNA for p a n c r e a t i c m a l i g n a n c i e s . (Abstract# E0488) RA Erickson, L Sayage-Rabie and RS Beissner. Temple, TX Endoscopic ultrasound staging in patients with pancreatic carcinoma versus patients with pancreatic c a r c i n o m a i n t h e b a c k g r o u n d of c h r o n i c p a n c r e a t i t i s . (Abstract# E0484) D Ciaccia, T Imperiale, M A1-Assi, J Kiel and S Sherman. Indianapolis, IN D i f f e r e n t i a l d i a g n o s i s of n e o p l a s t i c cysts of t h e p a n c r e a s b y e n d o s c o p i c u l t r a s o n o g r a p h y . (Abstract# E0490) T Fujii, T Obara, S Tanno, O Izawa, N Nishino, H Ura and Y Kohgo. Asahikawa, Japan E v a l u a t i o n of i n t e r o b s e r v e r a g r e e m e n t for a s s e s s i n g l y m p h n o d e s t a g i n g in p a n c r e a t i c c a n c e r u s i n g c u r r e n t e n d o s c o p i c u l t r a s o u n d c r i t e r i a . (Abstract# E0493) F Gress, C Schmitt, M Catalano, J Affronti, K Binmoeller, P Stevens, T Savides, M Bhutani, D Ciaccia, N Nickl, D Faigel, J Birk, L Roubein and C Lightdale. Stony Brook, NY; Chattanooga, TN; Tampa, FL; San Diego, CA; Dayton, OH; Indianapolis, IN and Portland, OR C o m p a r i s o n of CA19-9 t u m o r m a r k e r w i t h c o m p u t e d t o m o g r a p h y a n d e n d o s c o p i c u l t r a s o u n d - g u i d e d fine n e e d l e a s p i r a t i o n i n t h e d i a g n o s i s a n d s t a g i n g of p a n c r e a t i c cancer. (Abstract# E0495) K Hata, P Nguyen and KJ Chang. Orange, CA

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The n e g a t i v e p r e d i c t i v e v a l u e of endoscopic u l t r a s o u n d i n p a t i e n t s w i t h s u s p e c t e d p a n c r e a t i c cancer. (Abstract# E0511) P Nguyen, NS Ghazourian, K Hata and KJ Chang. Orange, CA

The role of endoscopic u l t r a s o n o g r a p h y i n r e c t a l carcinoid t u m o r . (Abstract# E0499) SJ Lee, HJ Chun, YT Jeen, KH Kim, HJ Park, SH Urn, SW Lee, JH Choi, CD Kim, HS Ryu and JH Hyun. Seoul, Korea

DDW Poster of Distinction:

Elevated CA19.9 levels a n d e n d o s c o p i c u l t r a s o n o g r a p h y . (Abstract# E0485) PH Deprez, V Gfllard, D Sch0onbroodt, P H0ang, Y H0rsmans, H Piessevaux and A Geubel. St Lue, Brussels and Liege, Belgium

A large series of p a t i e n t s w i t h ascites o n endoscopic ultrasounet: (Abstract# E0510) P Nguyen, J Le and KJ Chang. Orange, CA

DDW Poster of Distinction: Is e x t r a l u m i n a l f l u i d at endoscopic u l t r a s o n o g r a p h y a n a c c u r a t e m a r k e r of p e r i t o n e a l carcinomatosis? A prospective study. (Abstract# E0474) M Canto and G Gislas0n. Baltimore, MD Usefulness of endoscopic u l t r a s o n o g r a p h y i n p a t i e n t s w i t h deep pelvic e n d o m e t r i o s i s . (Abstract# E0519) G Roseau, I Dumontier, L Palazzo, C Chapron, B D0usset, S Chaussade, JB Dubuisson and D Couturier. Paris, France A prospective c o n t r o l l e d s t u d y of c a t h e t e r probe assisted e n d o l u m i n a l u l t r a s o n o g r a p h y i n i n f l a m m a t o r y bowel disease. (Abstract# E0524) AM Soweid, A Chak, J Katz and MV Sivak, Jr. Cleveland, OH Endoscopic u l t r a s o n o g r a p h y i n the diagnosis of d e p t h of colorectal s u b m u c o s a l c a n c e r i n v a s i o n . (Abstract# E0481) ECho, N Mochizuki, T Ashihara, K Yasuda and M Nakajima. Kyoto, Japan E n d o s o n o p r o b e e x a m i n a t i o n of colorectal t u m o r s u s i n g t w o - c h a n n e l e l e c t r o n i c videocolonoscope. (Abstract# E0512) Y Niwa, H Goto, T Arisawa, T Watanabe, K Tachi, H Kameyama, M Matsui, N Nomura, T Hosoi, M Shinkai and T Hayakawa. Nagoya, Japan

II

Endoscopic u l t r a s o u n d - g u i d e d h e p a t i c o g a s t r o s t o m y to palliate o b s t r u c t i v e j a u n d i c e : p r e l i m i n a r y r e s u l t s i n pigs. (Abstract# E0052) AV Sahai, BJ Hoffman and RH Hawes. Charleston, SC EUS-guided r a d i o f r e q u e n c y a b l a t i o n i n the p a n c r e a s : p r e l i m i n a r y r e s u l t s i n a p o r c i n e model. (Abstract# E0037) S Mallery, SN Goldberg and WR Brugge. Boston, MA C o m p a r i s o n of EUS-guided, CT-guided a n d i n t r a o p e r a t i v e needle biopsy of p a n c r e a t i c masses. (Abstract# E0503) S Mallery, B Centeno, P Hahn, A Warshaw and WR Brugge. Boston, MA Poster Grand Rounds

5:30-6:30 p m

Room 80/81 Ernest N. Morial Convention Center'

5:30 Esophagus.

Kenneth K. Wang. Rochester, MN 5:50 Stomach a n d D u o d e n u m ] G I Bleeding. Christopher J. Gostout. Rochester, MN 6:10 Colon a n d Rectum.

John H. Bond. Minneapolis, MN

April 1998

PROGRAM OF THE ANNUAL MEETING P123

TUESDAY, MAY 19, 1998

I

SOCIETY FOR THE SURGERY OF THE ALIMENTARY TRACT DDW Combined Clinical Symposium 8:30-10:00 am Room 100 / 101/102 Ernest N. Morial Convention Center

DDW Combined Clinical Symposium 10:30 am-12:00 p m Room 9 0 / 9 1 / 9 2 Ernest N. Morial Convention Center

S p o n s o r e d b y AGA/SSAT/AASLD

S p o n s o r e d by: ASGE/AGA/SSAT

Chairs: Byers Shaw, Michael R. Lucey

Chairs: Blair S. Lewis, Donald C. Rockey

ETHICS IN LIVER TRANSPLANTATION: PURSUING E X C E L L E N C E I N T H E M A N A G E D CARE E R A

OCCULT GI B L E E D I N G

8:30

A patient's perspective. Donald Rager. Las Vegas, NV

Attendees will learn about appropriate diagnostic tests to evaluate patients with occult GI bleeding and iron deficiency. New information about medical hormonal therapies, endoscopic therapy and the role of surgery will be discussed.

8:45

A provider's prospective. John Fung. Pittsburgh, PA

10:30

I n t r o d u c t i o n a n d overview. Donald C. Rockey. Durham, NC

9:00

A payor's perspective. Courtney Jennings. Chicago, IL

10:40

9:15

An ethieist's perspective. Ruth Pertilo. Omaha, NE

D i a g n o s t i c a p p r o a c h to t h e p a t i e n t w i t h occult GI bleeding. John F. Morris. Scotland, UK

10:55

E v a l u a t i o n of i r o n d e f i c i e n c y a n e m i a a n d fecal occult blood. Donald C. R0ckey, Durham, NC

11:10

H o r m o n a l a n d o t h e r t h e r a p i e s in p a t i e n t s w i t h occult GI b l e e d i n g . Blair S. Lewis. New York, NY

11:25

To o p e r a t e o r n o t i n p a t i e n t s w i t h occult GI bleeding. Brian Katz. New York, NY

11:40

Discussion

9:30

Discussion.

SSAT Scientific Presentations

8:30-10:00 am

Room 103/104 Ernest N. Morial Convention Center

Chairs: Andrew Warshaw, David Fromm CLINICAL PAPERS I 8:30

8:45

9:00

9:15

9:30

9:45

M o l e c u l a r g e n e t i c s of p a n c r e a t i c cancer. (Abstract# S0029) RJ Bold, DB Evans, KR Hess, AM Grau, F Sinicrope, KR Cleary, PJ Chiao and JL Abbruzzese. Houston, TX S t a g i n g l a p a r o s c o p y for p a n c r e a t i c c a n c e r s h o u l d b e u s e d to select t h e b e s t p a l l i a t i o n , n o t to i n c r e a s e r e s e c t i o n r a t e . (Abstract# S0149) E Luque-de LeSn, GG Tsiotes, BM Balsiger, J Barnwell, L Burgart and MG Sarr. Rochester, MN M a j o r v a s c u l a r r e s e c t i o n as p a r t of p a n c r e a t i c o d u o d e n e c t o m y for cancer: clinical, r a d i o l o g i c a n d p a t h o l o g i c analysis. (Abstract# S0028) RJ Bold, C Charnsangavej, KR Cleary, JE Lee, PWT Pisters and DB Evans. Houston, TX E a r l y f a i l u r e of i n t e s t i n a l b a r r i e r f u n c t i o n a n d endotoxemia in severe acute pancreatitis. ( A b s t r a c t # S0010) BJ Ammori, PG Leeder, RFG King, GR Barclay, IG Martin, M Larvin and MJ McMahon. Leeds, United Kingdom and Edinburgh, Scotland L a p a r o s c o p i c Roux-en-Y g a s t r i c b y p a s s : i n i t i a l r e s u l t s . (Abstract# S0223) PR Schauer, S Ikramuddin and W Gourash. Pittsburgh, PA M a l a b s o r p t i v e p r o c e d u r e s for s e v e r e obesity: c o m p a r i s o n of p a n c r e a t i c o b i l i a r y b y p a s s a n d very, v e r y l o n g Roux-en-Y g a s t r i c b y p a s s . ( A b s t r a c t # S0170) MM Murr, BM Balsiger, FP Kennedy and MG Sarr. Rochester, MN

SSAT Scientific Presentations

10:30 am-12:00 p m

Room 103/104 Ernest N. Morial Convention Center

Chairs: David Fromm, Joel Roslyn C L I N I C A L P A P E R S II 10:30

L a p a r o s c o p i c c h o l e c y s t e c t o m y as a ' t r u e ' o u t p a t i e n t p r o c e d u r e : i n i t i a l e x p e r i e n c e in 100 c o n s e c u t i v e p a t i e n t s . (Abstract# S0141) KD Lillemoe, JM Hardacre, MA Talamini, CJ Yeo, DS Snyder and SD Parker. Baltimore, MD

10:45

E v a l u a t i o n of l a p a r o s c o p i c c h o l e c y s t e c t o m y i n p a t i e n t s w i t h h e p a t i c c i r r h o s i s : a five y e a r experience. (Abstract# S0069) C Friel, J Stack, RA Forse and T Babineau. Boston, MA

11:00

Diagnosis a n d m a n a g e m e n t of cholangiocarcinoma in primary sclerosing cholangitis. (Abstract# S0005) SA Ahrendt, HA Pitt, A Nakeeb, AS Klein, KD Lillemoe, AN Kall00 and JL Cameron. Baltimore, MD and Milwaukee, WI

11:15

Presidential Address Andrew Warshaw. Boston, MA

P124 PROGRAM OF THE ANNUAL MEETING

G A S T R O E N T E R O L O G Y Vol. 1141 No. 4

II

TUESDAY, MAY 19, 1998 DDW Combined Clinical Symposium

DDW Combined Clinical Symposium

2:15-3:45 p m

2:15-3:45 p m

Ballroom A / B Ernest N. Morial Convention Center

Room 90/91 / 92 Ernest N. Morial Convention Center

S p o n s o r e d by: ASGE/SSAT/AASLD

S p o n s o r e d b y AASLD/SSAT/AGA

Chairs: Jeffrey L. Ponsky, Lawrence W. Way

Chairs: Douglas R. Labrecque, David M. Nagorney

MINIMALLY INVASIVE MANAGEMENT OF COMMON BILE DUCT STONES

HEPATOCELLULAR CANCER

Attendees will learn about laparoscopic approaches to managing common bile duct stones, and the integration of ERCP and laparoscopic techniques. 2:15

Laparoscopic transcystic stone extraction. Joseph Petelin. Kansas City, KS

2:40

Laparoscopic choledochotomy. Lawrence W. Way. San Francisco, CA

3:05

I n t e g r a t i o n of l a p a r o s c o p i c a n d E R C P for c o m m o n b i l e d u c t stones. Jeffrey L. P0nsky. Cleveland, OH

3:30

Discussion.

DDW Combined Clinical Symposium

2:15-3:45 p m

Room 100 / 101/102 Ernest N. Morial Convention Center

S p o n s o r e d by: SSAT/AGA/ASGE

2:15

Introduction. Douglas R. Labrecque. Iowa City, IA

2:30

Hepatocarcinogenesis

- therapeutic

implications. Snorri Thorgeissen. Bethesda, MD 2:45

N o n - s u r g i c a l a b l a t i o n - chemical, t h e r m a l , o r embolic? Massimo Colombo. Milan, Italy

3:00

Partial hepatectomy - the gold standard? Yuman Fong. New York, NY

3:15

Total h e p a t e c t o m y / t r a n s p l a n t a t i o n - t h e n e w gold s t a n d a r d ? Roger Jenkins. Boston, MA

3:30

P a n e l Discussion. David M. Nagorney. Rochester, MN

SSAT Scientific Presentations

2:15-3:45pm

Chairs: Andrew L. Warshaw, Peter A. Banks

Room 103/104 Ernest N. Morial Convention Center

SEVERE ACUTE PANCREATITIS

Chairs: John Hunter, Carlos Pelligrini

2:15

CLINICAL PAPERS III

M e d i c a l s t r a t e g y - i n h i b i t i o n of i n f l a m m a t o r y mediators. James Norman. Tampa, FL

2:25

Radiologic strategy. Eric van Sonnenberg. Galveston, TX

2:35

E n d o s c o p i c s t r a t e g y - ERCP, s t e n t i n g drainage. Richard A. Kozarek. Seattle, WA

2:45

Surgical strategy - early surgery, late surgery, or no surgery. Carlos Fernandez-del Castill0. Boston, MA

2:55

Case P r e s e n t a t i o n s .

2:15

Improved functional outcome after laparoscopic fundoplication by complete g a s t r i c f u n d u s m o b i l i z a t i o n . (Abstract# S0050) J Dalenb~ck, H L~nroth, A Blomqvist and L LundeU. Gothenburg, Sweden

2:30

M u l t i v a r i a t e a n a l y s i s of t h e f a c t o r s p r e d i c t i n g outcome after laparoscopic Nissen

f u n d o p l i c a t i o n . (Abstract# S0038) GMR Campos, JH Peters, TR DeMeester, S Oberg, M DeV0s-Shoop, J Theisen, M Hashemi, P Crookes, J Hagen and CG Bremner. Los Angeles, CA 2:45

L a p a r o s c o p i c T o u p e t is a n i n a d e q u a t e p r o c e d u r e for p a t i e n t s w i t h s e v e r e r e f l u x disease. (Abstract# S0091) KD Horvath, BA Jobe and LL Swanstrom. Portland, OR

3:00

B a r r e t t ' s e s o p h a g u s : a s u r g i c a l disease. ( A b s t r a c t # S0189)

MG Patti, CV Feo, M Arcerit0, S Worth, M De Pinto, J Tong, VC Gibbs, M Ahmadi, W Gantert, D Tyrrell, LD Ferrell and LW Way. San Francisco, CA 3:15

E n d o s c o p i c l a s e r a b l a t i o n of B a r r e t t ' s m u c o s a f o l l o w e d b y Nissen f u n d o p l i c a t i o n : r e s u l t s of a p i l o t s t u d y . (Abstract# S0039) A Carazzone, L Bonavina, A Segalin, L Ant0niazzi, C Ceriani and A Peracchia. Milan, Italy

3:30

Variability in the composition of physiologic d u o d e n o g a s t r i c reflux. (Abstract# S0071) K-H Fuchs, J Maroske, M Fein, H Tigges, MP Ritter, J Heimbucher and A Thiede. Wtirzburg, Germany

PROGRAMOF THEANNUALMEETINGP125

April 1998

II

TUESDAY, MAY 19, 1998

SSAT Scientific Presentations

4:00-5:30 p m

4:30

Heal p o u c h salvage following failed ileal p o u c h - a n a l anastomosis. (Abstract# S0218) S Saltzberg, C DiEdwardo, T Scott, W LaMorte and JM Becker. Boston, MA

4:45

Hospital p r o c e d u r e v o l u m e a n d hospital t e a c h i n g s t a t u s do n o t i n f l u e n c e operative m o r t a l i t y or long t e r m s u r v i v a l for rectal c a n c e r i n a large g e n e r a l p o p u l a t i o n : a n outcomes study. (Abstract# S0239) M Simunovic, E Sigurdson, T To, N Baxter, A Balshem, Z Cohen, R McLeod and E Ross. Toronto, Canada and Philadelphia, PA

5:00

B2 r e c t a l cancer: is r a d i a t i o n t h e r a p y for local control n e c e s s a r y ? (Abstract# 80160) NB Merchant, JG Guillem, PB PaW, WE Enker and AM Cohen. New York, NY

5:15

Efficacy of c o m b i n e d c h e m o - r a d i a t i o n t h e r a p y for e p i d e r m o i d c a r c i n o m a of the a n a l c a n a l for t u m o r s l a r g e r t h a n 5 c e n t i m e t e r s . (Abstract#

Room 103/104 Ernest N. Morial Convention Center

Chairs: Robert Beart, James Becker CLINICAL P A P E R S IV 4:00

4:15

I m p l e m e n t a t i o n of a clinical p a t h w a y decreases l e n g t h of stay a n d cost for bowel resection. (Abstract# S0200) TA Pritts, MS Nussbaum, LV Flesch, EJ Fegelman, AJ Parikh and JE Fischer. Cincinnati, OH The c u m u l a t i v e r i s k of developing polyps or m a l i g n a n c y at the fleo-pouch-anal a n a s t o m o s i s i n p a t i e n t s with familial a d e n o m a t o u s polyposis. (Abstract# S0261) P van Duijvendijk, JFM Slors, CW Taat, S Biil0w, L Bertario, JHC Kuijpers, WR Sch0uten, JG Guillem and HFA Vasen. Amsterdam, Nijmegen and Rotterdam, The Netherlands; Denmark; Italy and New York, NY

S0187)

PS Paik, L Leichman, O Streeter, Jr and RW Beart, Jr. Los Angeles, CA

P126 PROGRAM OF THE ANNUAL MEETING

GASTROENTEROLOGYVol. 114~No. 4

THE A M E R I C A N ASSOCIATION FOR THE S T U D Y OF LIVER D I S E A S E S THE A M E R I C A N GASTROENTEROLOGICAL A S S O C I A T I O N 1998 F o c u s e d C l i n i c a l / R e s e a r c h U p d a t e s TOPIC Gastr0paresis: new m0dalities Pancreatitis Functional bowel disease H. pylori and cancer IBD - new therapies Variceal bleeding - portal hypertension Visceral sensitivity NSAIDs - clinical GERD and dysphagia Outcomes research Colon cancer screening Pancreatic secretion

SPEAKER Richard McCallum, M.D. James H. Grendel4 M.D. Kevin W. Olden, M.D. Amnon Sonnenberg, M.D. William J. Sandborn~ M.D. Thomas D. Boyer, M.D. Michael Camilleri, M.D. James Schieman~ M.D. Peter J. Kahrilas~ M.D. Dawn Provenzale, M.D, M.S. Steven Itzkowitz~ M.D. Chung Owyang, M.D.

Co-sponsored by Manpower and Training Committee

DDW C o m b i n e d Clinical S y m p o s i u m 8:30-10:00 am Ballroom A / B Ernest N. Morial Convention Center Sponsored by: AGA/ASGE

Chair:

Chairs: Michael Camilleri, Kenneth McQuaid

AGA Research Symposium 6:45-8:00 am Room 37 Ernest N. Morial Convention Center

David A. Brenner. Chapel Hill, NC

F U N D I N G O P P O R T U N I T E S I N GI R E S E A R C H

NIH funding opportunities. Jay H. H0ofnagle. Bethesda, MD Grant writing. Frederick J. Suchy. New York, IVY

GASTRIC D Y S P E P S I A

8:30

Cost-effective approach to dyspepsia and the potential impact of small scopes. Josh Ofman. Beverly Hills, CA

8:45

Current and future role of endoscopy in dyspepsia. Peter Bytzer. G10strap, Denmark

9:00

Critical appraisal of current therapies. Kenneth McQuaid. San Francisco, CA

9:20

Sensation, accommodation, and new approaches to therapy. Michael Camilleri. Rochester, MN

9:30

Discussion.

Funding opportunities from foundations. C. Richard Boland. La Jolla, CA AGA Business Meeting 7:30-8:30 am Room 99 Ernest N. Morial Convention Center AGA State of the Art Lecture 8:30-9:30 am Room 85/86 Ernest N. Morial Convention Center

Sponsored by Biliary Disorders Chairs: S u m P. Lee, Frieder Berr F U N C T I O N AND D Y S F U N C T I O N O F T H E BILIARY EPITHELIUM: CLINICAL IMPLICATIONS

Function. J. Gregory Fitz. Denver, CO Dysfunction. Nicholas LaRusso. Rochester, MN

DDW C o m b i n e d Clinical S y m p o s i u m 8:30-10:00 am Room 100 / 101 / 102 Ernest N. Morial Convention Center Sponsored b y AGA/SSAT/AASLD Chairs: Byers Shaw, Michael R. Lucey E T H I C S I N LIVER T R A N S P L A N T A T I O N : P U R S U I N G E X C E L L E N C E IN T H E M A N A G E D CARE E R A

8:30

A patient's perspective. Donald Rager. Las Vegas, NV

8:45

A provider's prospective. John Fung. Pittsburgh, PA

9:00

A payor's perspective. C0urtney Jennings. Chicago, IL

9:15

An ethicist's perspective. Ruth Pertfl0. Omaha, NE

9:30

Discussion.

Panel Discussion. AGA S t a t e o f t h e A r t L e c t u r e 8:30-9:30 am Room 90/91/92 Ernest N. Morial Convention Center Sponsored by Clinical P r a c t i c e Co-sponsored by Esophageal, Gastric, and Duodenal Disorders and Gastrointestinal Oncology Chair:

Richard Sampliner

Common diagnostic errors in GI pathology: when to ask for an expert opinion. Rodger C. Haggitt. Seattle, WA

A p r i l 1998

P R O G R A M O F T H E A N N U A L M E E T I N G P127

TUESDAY, MAY 19, 1998 AGA Clinical Symposium 8:30-10:00 am Room 4 1 / 4 2 / 4 3 Ernest N. Morial Convention Center S p o n s o r e d b y G a s t r o i n t e s t i n a l Oncology Co-sponsored b y I m m u n o l o g y , Microbiology, a n d I n f l a m m a t o r y D i s o r d e r s a n d Clinical Practice

Chair:

Bernard Levin

COLON CANCER S C R E E N I N G AND SURVEILLANCE

AGA Topic Forum 8:30-10:00 am

Chairs: Jan Tack, William L. Hasler FUNDIC RELAXATION: P E R C E P T I O N , DYSPEPSIA, AND PAIN 8:30

H e a l t h care s e e k i n g for d y s p e p s i a i n a c o m m u n i t y sample: role of the p a i n experience, c o m o r b i d illness a n d h e a l t h - r e a l t e d q u a l i t y of life. (Abstract# G0164) MJ Shaw, TJ Beebe and SA Adlis. Minneapolis, MN and Penrith, Australia

8:45

Are f u n d i c receptors s e n s i t i v e to c i r c u m f e r e n t i a l wall t e n s i o n i n vivo? (Abstract# G3241) L Lepionka and CH Malbert. St Gilles, France

9:00

P e r c e p t i o n of p h a s i c t e n s i o n changes i n the p r o x i m a l s t o m a c h i n m a n . (Abstract# G3375) H Piessevaux, J Tack, B Coulie, A Geubel and J Janssens. Leuven and Brussels, Belgium

9:15

Rectogastric r e f l e x - i n d u c e d gastric h y p e r s e n s i t i v i t y to m e c h a n i c a l d i s t e n t i o n a n d meal ingestion: a possible model for dyspepsia w i t h f u n c t i o n a l lower g u t disorders. (Abstract# G3363) S Park, F Hooper, J Palaniappan, C Owyang and W Hasler. Ann Arbor, MI

9:30

Postcibal gastric s e n s o r y a n d m o t o r d y s f u n c t i o n s i n n o n - u l c e r dyspepsia: w h a t are the role of Helicobacterpylori i n f e c t i o n a n d vagal f u n c t i o n ? (Abstract# G3477) M Thumshirn, SB Saslow, M Camilleri, D Burton, R Hanson and DE Williams. Rochester, MN

9:45

S e n s i t i v i t y to i n t r a d u o d e n a l lipid i n f u s i o n i n p a t i e n t s with dysmotility-like versus ulcer-like f u n c t i o n a l dyspepsia. (Abstract# G0352) A Castro, F Mearin and J-R Malagelada. Barcelona, Spain

Average r i s k p o p u l a t i o n . Bernard Levin. Houston, TX Genetically high risk population. Francis M. Giardiello. Baltimore, MD S u r v e i l l a n c e i n IBD. John E. Lennard-Jones. London, England AGA Research Symposium 8:30-10:00 am Room 93/94 Ernest N. Morial Convention Center S p o n s o r e d b y P a n c r e a t i c Disorders Co-sponsored b y Growth, Development, N u t r i t i o n

Chairs: Laurence J. Miller, Fred S. Gorelick ANIMAL MODELS RELEVANT TO PANCREATIC DISEASE The cystic fibrosis m o u s e model i n p a n c r e a t i c physiology. Steven D. Freedman. Boston, MA A m o u s e model of the h e r e d i t a r y p a n c r e a t i t i s gene defect. Charles D. Ulrich. Cincinnati, OH Cytokine k n o c k o u t mice i n p a n c r e a t i c disease. Michael L. Steer. Boston, MA AGA Research Symposium 8:30-10:00 am Room 97/98 Ernest N. Morial Convention Center S p o n s o r e d b y I n t e s t i n a l Disorders

Chair:

Jeffrey Matthews

THE E P I T H E L I A L R E S P O N S E TO STRESS E p i t h e l i a l r e s p o n s e to metabolic stress: role of a d e n o s i n e a n d ATP. Jeffrey B. Matthews. Boston, MA R e g u l a t i o n of s u p e r o x i d e d i s m u t a s e by p r o i n f l a m m a t o r y m e d i a t o r s : a cytoprotective mechanism. John F. Valentine. Gainesville, FL I n t e s t i n a l e p i t h e l i a l h e a t shock p r o t e i n s - g u a r d i a n s a g a i n s t i n f l a m m a t i o n - i n d u c e d stress. Eugene B. Chang. Chicago, IL

Room 40 Ernest N. Morial Convention Center

P128PROGRAMOFTHEANNUALMEETING

El

GASTROENTEROLOGYVol.114~No. 4

TUESDAY, MAY 19, 1998

AASLD Research Forum

8:30-10:00 am

9:00

P r e n a t a l t o l e r i z a t i o n to r e c o m b i n a n t a d e n o v i r u s p e r m i t s l o n g t e r m c o r r e c t i o n of b i l i r u b i n g l u c u r o n i d a t i o n defect i n G u n n r a t s b y r e p e a t e d a d e n o v i r u s - m e d i a t e d gene therapy. (Abstract# L0261) Y Ilan, BS Sauter, N Roy Chowhury, NR Thummala, A Davidson, MS Horwitz and J Roy Chowdhury. New York, NY

9:15

The m a j o r gallstone gene (Lithl) is r e s p o n s i b l e for b i l i a r y cholesterol (Ch) h y p e r s e c r e t i o n a n d Ch gallstone f o r m a t i o n i n c o n g e n i c mice (AKR.L-LithlS). (Abstract# L0669) DQ-H Wang, F Lammert, B Paigen and MC Carey. Boston, MA and Bar Harbor, ME

9:30

Specific c o m p o n e n t s of t h e u b i q u i t i n system are r e q u i r e d for i n t r a c e l l u l a r d e g r a d a t i o n of m u t a n t a l - a n t i t r y p s i n Z. (Abstract# L0635) JH Teckman, N Marcus and DH Perlmutter. St Louis, MO

9:45

P o p u l a t i o n s c r e e n i n g for h e m o c h r o m a t o s i s with t h e u n b o u n d i r o n b i n d i n g capacity. (Abstract# L0005) PC Adams, AE Kertesz, R Barr, A Bamford and S Chakrabarti. London, Canada

Room 80/81 Ernest N. Morial Convention Center

Chairs: Dwayne Thiele, Keith D. Lindor A U T O I M M U N E LIVER D I S E A S E S 8:30

G e n o m i c a s s o c i a t i o n s i n AMA-positive a n d AMA-negative p r i m a r y b i l i a r y cirrhosis. (Abstract# L0607) J Stone, JA Wade, K Cauch-Dudek, C Ng, KD Lindor and EJL Heathcote. Toronto, Canada and Rochester, MN

8:45

F r e q u e n c y a n d s i g n i f i c a n c e of the v a r i a n t s y n d r o m e s of a u t o i m m u n e hepatitis. (Abstract# L0126) AJ Czaja. Rochester, MN

9:00

A randomized controlled trial evaluating t h e r a p y w i t h ursodeoxycholic acid i n daily doses of 10 mg/kg v e r s u s 20 mg/kg i n p r i m a r y b i l i a r y cirrhosis. (Abstract# L0656) HJF van Hoogstraten, MBM de Smet, W Ren00ij, WCJ Hop, HR van Buuren, GP vanBergeHenegouwen and SW Schalm. Rotterdam, The Netherlands

9:15

9:30

9:45

A b e r r a n t co-expressions of c y t o k e r a t i n subclass a n d ICAM-1 i n d e s t r u c t i v e bile ducts a n d s e r u m levels of a n t i - c y t o k e r a t i n subclass a n t i b o d y a n d soluble ICAM-1 - a c o m p a r i s o n b e t w e e n a u t o i m m u n e cholangitis a n d p r i m a r y b i l i a r y cirrhosis. (Abstract# L0285) Y Kamegaya, M Oda, H Yokomori, S Miyaguchi, H K0matsu, N Tsukada, K Yonei and H Ishii. Tokyo, Japan I n c i d e n c e of c a n c e r i n p r i m a r y b i l i a r y cirrhosis: the Mayo experience. (Abstract# L0464) PK Nijhawan, TM Therneau, ER Dicks0n and KD Lindor. Rochester, MN

Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum

8:30-10:00 am

Chairs: Terrence A. Barrett, Martin F. Kagnoff MUCOSAL IMMUNOLOGY II 8:30

Altered epithelial b a r r i e r f u n c t i o n i n a sensitized host is p r e s e n t i n the a b s e n c e of inflammation/. (Abstract# G3812) MC Berin, LA Ciok, P-C Yang and MH Perdue. Hamilton, Canada

8:45

Bone m a r r o w r e c o n s t i t u t i o n of MHC II deficient mice: d e f i n i n g t h e role of class II a n t i g e n p r e s e n t a t i o n a n d CD4+ve T cells i n intestinal inflammation and enteric muscle dysfunction. (Abstract# G4515) BA Vallance, DP Snider and SM Collins. Hamilton, Canada

9:00

Oral t o l e r a n c e i n h u m a n s - d u r a t i o n of f e e d i n g alters t h e m e c h a n i s m s of t o l e r a n c e p r o d u c t i o n to soluble p r o t e i n a n t i g e n s . (Abstract# G3844) JR Boulton-Jones and A Ferguson. Edinburgh, Scotland

9:15

T cells from the small i n t e s t i n a l m u c o s a of celiac disease p a t i e n t s recognize a u n i q u e p e p t i d e sequence of gliadin. (Abstract# G4523) Y van de Wal, Y Kooy, P van Veelen, S Pefia. 0 Molberg, K Lundin, L Sollid, T Mutis, W Benckhuijsen, JW Drijfhout and F Koning. Leiden and Amsterdam, The Netherlands; Oslo, Norway

9:30

C h e m o k i n e r e c e p t o r e x p r e s s i o n is i n c r e a s e d o n m u c o s a l versus blood CD4+ T Cells. (Abstract# G3983) J Elliott, J Giorgi, L Hultin, CR MacKay, M Poles and PA Anton. Los Angeles, CA and Cambridge, MA Differential cell surface e x p r e s s i o n of t h e p r i n c i p a l coreceptor for m a c r o p h a g e - t r o p i c HIV-1 (CCR5) o n i n t e s t i n a l m a c r o p h a g e s a n d blood monocytes. (Abstract# G4247) G Meng, Y Jiang and PD Smith. Birmingham, AL

The Mayo r i s k score i n c r e a s e s r a p i d l y i n the t e r m i n a l p h a s e of p r i m a r y sclerosing cholangitis. (Abstract# L0315) WR Kim, KD Lindor, JJ Poterucha, JT Benson, TM Therneau and ER Dickson. Rochester, MN

AASLD Research Forum

8:30-10:00 am

Room 82/83 Ernest N. Morial Convention Center

Chairs: Jayanta Roy Chowdhury, Paul A d a m s G E N E T I C LIVER D I S E A S E S 8:30

8:45

Molecular a n a l y s i s of Jagged1 i n 26 Alagille s y n d r o m e families d e m o n s t r a t e s t h a t n e a r l y all m u t a t i o n s are p r i v a t e a n d r e s u l t i n p r e m a t u r e p r o t e i n t e r m i n a t i o n a n d loss of the t r a n s m e m b r a n e d o m a i n . (Abstract# G3649) I Krantz, NB Spinner, R CoUiton, A Genin and DA Piccoli. Philadelphia, PA Effect of b i l i r u b i n UDPg l u c u r o n o s y l t r a n s f e r a s e 1 gene TATA box o n serum bilirubin concentrations in chronic liver i n j u r y . (Abstract# L0155) H Doyama, T Okada, T K0bayashi, Y Takeda and H Mabuchi. Ishikawa, Japan

Room 11 Ernest N. Morial Convention Center

9:45

April 1998

PROGRAM OF THE ANNUAL MEETING P129

TUESDAY, MAY 19, 1998 Pancreatic Disorders AGA Research Forum 8:30-10:00 am Room 1 3 / 1 5 / 1 7 Ernest N. Morial Convention Center

Chairs: Lawrence K. Gates, Jonathan E. Clain

9:00

The o n s e t a n d c h r o n i c i t y of e x p e r i m e n t a l colitis is m o d u l a t e d b y p r o i n f l a m m a t o r y peptides. (Abstract# G4469) S Sturiale, G Barbara, BS Qiu, E Grady, N Bunnett and SM Collins. Hamilton, Canada and San Francisco, CA

9:15

Selective i n h i b i t i o n of TNF-a-mediated COX-2 b u t n o t c o n s t i t u t i v e COX-1 gene e x p r e s s i o n i n HT-29 cells u s i n g a specific NF-KB i n h i b i t o r . (Abstract# G4U4) C Jobin, O Morteau, DS Han and RB Sartor. Chapel Hill, NC

9:30

Susceptibility of mice w i t h specific NOS gene deletions to e x p e r i m e n t a l colitis. (Abstract# G4360) BS Qiu, H Mashimo, BA Vallance, PA Blennerhassett and SM Collins. Hamilton, Canada and Boston, MA

9:45

R e g u l a t e d a n d p o l a r i z e d n i t r i c oxide release b y h u m a n colon e p i t h e l i a l cells. (Abstract# G4563) T Witth6ft, L Eckmann and MF Kagnoff. La JoUa, CA

CLINICAL P A N C R E A T I T I S 8:30

8:45

9:00

9:15

9:30

9:45

D r a i n a g e v e r s u s r e s e c t i o n i n surgical t r e a t m e n t of c h r o n i c p a n c r e a t i t i s - prospective r a n d o m i z e d t r i a l c o m p a r i n g the F r e y procedure with pylorus-preserving p a n c r e a t o d u o d e n e c t o m y . (Abstract# G1916) JR Izbicki, C Bloechle, DC Br0ering, WT Kn0efel, T Kuechler and CE Br0elsch. Hamburg, Germany Extracellular phospholipases A2 i n severe acute p a n c r e a t i t i s associated systemic i n f l a m m a t o r y response syndrome, (Abstract# G1907) A Hietaranta, E Kemppainen, P Pu01akkainen, V Sainio, R Haapiainen, E Kivilaaks0 and T Nevalainen. Helsinki and Turku, Finland C a n EUS detect e a r l y or severe c h r o n i c p a n c r e a t i t i s ? C o m p a r i s o n of endoscopic u l t r a s o n o g r a p h y w i t h p a n c r e a t i c function. (Abstract# G2007) M Raimondo, JE Clain, KK Wang and EP DiMagno. Rochester, MN Risk factors for postoERCP p a n c r e a t i t i s : a p r o s p e c t i v e m u l t i c e n t e r study. (Abstract# G2026) S Sherman, G Lehman, M Freeman, J Watkins, J Barnett, E Fogel, J Johanson, J Geenen, M Ryan, H Parker, E Lazaridis, J Flueckiger, W Sflverman, K Dua, G Aliperti, P Yakshe, M Uzer, W Jones and J Goff. Indianapolis, IN lsC-labelled h i o l e i n b r e a t h test a s a n o n i n v a s i v e m e a s u r e m e n t of p a n c r e a t i c exocrine f u n c t i o n . (Abstract# G1782) ST Amann, JG Herrera, L S0m0gyi, M Cintr0n, D Wagner and PP Toskes. Gainesvflle, FL and Merrimack, NH C o m p a r i s o n of endoscopic u l t r a s o u n d a n d s e c r e t i n t e s t i n g for the diagnosis of m i n i m a l c h a n g e c h r o n i c p a n c r e a t i t i s . (Abstract# G1938) LR Lambiase, B Pollack, S Amann and CE Forsmark. New Orleans, LA and Gainesville, FL

Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum 8:30-10:00 am Room 19 Ernest N. Morial Convention Center

Chairs: Keith T. Wilson, William F. Stenson

Gastrointestinal Oncology AGA Research Forum 8:30-10:00 am Room 33/35 Ernest N. Morial Convention Center

Chairs: Raymond N. Dubois, Barbara C. Pence CYCLOOXYGENASES, EICOSANOIDS, AND CARCINOGENESIS 8:30

cancer

8:45

I n d u c i b l e - n i t r i c oxide s y n t h a s e activity s u p p r e s s e s l i p o p o l y s a c c h a r i d e i n d u c t i o n of toxic cytokines. (Abstract# G4173) FY Lee, HZ Lin, SQ Yang and AM Diehl. Baltimore, MD The role of p r o i n f l a m m a t o r y peptides i n the o n s e t of i n t e s t i n a l i n f l a m m a t i o n . (Abstract# G3793) G Barbara, R DeGi0rgio, P Blennerhassett, S Sturiale, E Grady, N Bunnett and SM Collins. Hamilton, Canada; Bologna, Italy and San Francisco, CA

cells results in constitutive

expression

of cyclooxygenase-2 p r o t e i n . (Abstract# G2398) DA Dixon, KJ Murphy and SM Prescott. Salt Lake City, UT 8:45

R e d u c e d COX-2 p r o t e i n e x p r e s s i o n i n h u m a n colorectal c a n c e r e x h i b i t i n g defective m i s m a t c h repair. (Abstract# G2541) WE Karnes, Jr, RN DuBois, Jr, R ShattuckBrandt, IM Burgart, DJ Tester and SN Thibodeau. Rochester, MN and Nashville, TN

9:00

Effect of cyclooxygenase-2 expression i n colon c a n c e r cells o n c h e m o t a x i s of n e u t r o p h i l s a n d macrophages. (Abstract# G2867) M Tsujii, S Kawano, S Tsuji, Y Takei, H Nagai, H Sawaoka, H Murata, N Kawai, M Hori and RN DuBois. Osaka, Japan and Nashville, TN

9:15

Enhanced lymphatic invasion and metastasis with cyclooxygenase-2 o v e r e x p r e s s i o n i n h u m a n gastric c a r c i n o m a . (Abstract# G2679) H Murata, S Kawano, S Tsuji, M Tsujii, H Sawa0ka, Y Kimura, H Shiozaki and M Hori. Osaka, Japan

9:30

Colon c a n c e r cell g r o w t h i n h i b i t i o n by t r e a t m e n t with a selective COX-2 i n h i b i t o r . (Abstract# G2471) AP Goldman, CS Williams, VP Williams and RN DuBois. Nashville, TN

9:45

Assessment of P P A R a a c t i v i t y i n the i n t e s t i n e . (Abstract# G2485) RA Gupta, JA Brockman and RN DuBois. Nashville, TN

MUCOSAL I N F L A M M A T I O N 8:30

Defective control of p r o t e i n synthesis i n colon

GASTROENTEROLOGY Vol. 114~No. 4

P130 PROGRAM OF THE ANNUAL MEETING

II

TUESDAY, MAY 19, 1998

E s o p h a g e a l , Gastric, a n d D u o d e n a l D i s o r d e r s AGA Research Forum 8:30-10:00 am Room 38 Ernest N. Morial Convention Center

Chairs: David R. Cave, Duane T. Smoot

9:00

G a s t r i n i n d u c e s C-los gene t r a n s c r i p t i o n v i a m u l t i p l e s i g n a l i n g p a t h w a y s . ( A b s t r a c t # G4839) V Stepan, M Tatewaki, M Matsushima, CJ Dickinson, J Del Valle and A Todisco. Ann Arbor, MI

9:15

The p e p t i d e Y Y Y1 r e c e p t o r s u b t y p e couples to MAP k i n a s e a c t i v a t i o n a n d cell p r o l i f e r a t i o n . (Abstract# G4753) PJ Mannon. Durham, NC

9:30

Proton pump inhibitors enhance progression through the adenoma carcinoma sequence and d e c r e a s e s s u r v i v a l i n t h e M/n m o u s e m o d e l of f a m i l i a l a d e n o m a t o u s p o l y p o s i s . (Abstract# G4832) AM Smith and SA Watson. Nottingham, United Kingdom

9:45

Calcium o s c i l l a t i o n p l a y s a n i m p o r t a n t r o l e i n t h e s i g n a l i n g p a t h w a y r e g u l a t i n g cell p r o l i f e r a t i o n v i a CCKB/gastrin r e c e p t o r . (Abstract# G4851) T Urushidani, K Akagi and T Nagao. Tokyo, Japan

HELIOCOBACTER P Y L O R I P A T H O G E N E S I S : E F F E C T S AT T H E GASTRIC M U C O S A L S U R F A C E 8:30

C h a r a c t e r i z a t i o n o f a pH-sensitive, IP 3independent c a l c i u m s t o r e i n g a s t r i c t u m o r (AGS) cells as a p o s s i b l e l i n k b e t w e e n H. p y l o ~ i n f e c t i o n a n d f u n c t i o n a l a l t e r a t i o n of t h e g a s t r i c e p i t h e l i u m . (Abstract# G1409) N Zeng, C Athmann, HT Yang, T Kang, D Scott, P Voland, H Helander, JH Walsh and G Sachs. Los Angeles, CA

8:45

C a l c i u m s i g n a l i n g in g a s t r i c cells e x p o s e d to cagA-positive a n d cagA-negative H. pylori s t r a i n s . (Abstract# G0463) K Elliget, MW Smith, H Ashktorab, CR Allen and DT Smoot. Baltimore, MD and Washington, DC

9:00

Helicobacterpylori a n d its f a t t y a c i d s d i f f e r e n t i a l l y i n c r e a s e i n t r a c e l l u l a r Ca2+ in g a s t r i c e p i t h e l i a l cells. (Abstract# G1332) S Wagner, T Feske, W Bell, MP Manns and C Sch6fl. Hannover, Germany

9:15

H e l i c o b a c t e r p y l o r i a n d Signal T r a n s d u c t i o n Stephen Pand01. Los Angeles, CA

9:30

Helieobavter p y l o ~ i n d u c e s m o l e c u l a r d i s r u p t i o n of g a s t r i c m u c o s a l t i g h t j u n c t i o n s . (Abstract# G0452) BE Dunn, AD LaBeaud, M Macias, MH Parlow, P Krishnamurthy, FA Pintar, NB Vakil and SH Phadnis. Milwaukee, WI

9:45

M o l e c u l a r c l o n i n g of h u m a n g a s t r i c m u c i n a n d b i n d i n g to Helieobaeterpylori. (Abstract# G1300) JHB van de B0venkamp, CM Hau, AWC Einerhand, P Roorda, A van der Ende, GJ Strous, HA Bfiller and J Dekker. Amsterdam, Utrecht and Rotterdam, The Netherlands

Hormones, Transmitters, Their Receptors AGA Research Forum

8:30-10:00 am

E s o p h a g e a l , Gastric, a n d D u o d e n a l D i s o r d e r s AGA Research Forum 8:30-10:00 am Room 5 8 / 5 9 / 6 0 Ernest N. Morial Convention Center

Chairs: Thomas Breuer, Gary W. Falk HELICOBACTER P Y L O R I AND GASTROESOPHAGEAL REFLUX DISEASE 8:30

The i m p a c t of H. pylori on h e a l i n g of r e f l u x esophagitis during treatment with p a n t o p r a z o l e . (Abstract# G0620) G Holtmann, CR Cain and P Malfertheiner. Essen, Constance and Magdeburg, Germany

8:45

Does c u r e of Helicobacterpyloriinfection i n d u c e h e a r t b u r n ? (Abstract# G0870) P Ma]fertheiner, SV van Zanten, J Dent, E Bayerd6rffer, T Lind, C O'Morain, RC Spiller, P Unge and L Zeijlon. Magdeburg, Germany

9:00

No i n c r e a s e of r e f l u x s y m p t o m s o r e s o p h a g i t i s i n p a t i e n t s w i t h n o n - u l c e r d y s p e p s i a 12 m o n t h s a f t e r Helicobacterpylori e r a d i c a t i o n . A randomized double-blind placebo-controlled trial. (Abstract# G1250) NJ Talley, J Janssens, K Lauritsen, I Ra~z, E Bolling-Sternevald, N Havu, 0 Junghard and G Sj6gren. Penrith, Australia

Growth Factors and

Room 44 Ernest N. Morial Convention Center

Chairs: John Del Valle, M. Michael Wolfe

9:15

8:30

8:45

R e v e r s i b l e i n d u c t i o n of m u c o u s cell h y p e r p l a s i a a n d p a r i e t a l cell loss i n r a t s d o s e d w i t h DMP-777. (Abstract# G4690) JR Goldenring, GS Ray, RJ C0ffey, Jr, PC Meunier, WE Evering, TB Barnes, SI Carter and BD Car. Augusta, GA; Nashville, TN and Newark, DE Transforming growth factor-a-mediated epithelial-mesenchymal interaction promotes f e t a l g a s t r i c e p i t h e l i a l cell growth. (Abstract# G4686) RE Glasgow, BC Visser and SJ Mulvihill. San Francisco, CA

I n c r e a s e of g a s t r i c a c i d s e c r e t i o n a f t e r H.

p y l o ~ eradication caused the development of

M E D I A T O R S O F E P I T H E L I A L C E L L G R O W T H AND PROLIFERATION

r e f l u x e s o p h a g i t i s . (Abstract# G0749) T K0ike, S Ohara, H Sekine, K IIjima, Y Kub0ta, K Katoh, S Asaki and T Toyota. Sendal, Japan 9:30

P r e v a l e n c e a n d d i s t r i b u t i o n of H. p y l o ~ i n g a s t r o e s o p h a g e a l r e f l u x disease: a s t u d y in China. (Abstract# G1364) JCY Wu, MYY Go, WB Chan, CL Choi, FKL Chan and JY Sung. Hong Kong, China

9:45

Is H e l i c o b a c t e r p y l o r i i n f e c t i o n p r o t e c t i v e a g a i n s t GERD? John Dent. Adelaide, Australia

A p r i l 1998

PROGRAM OF THE ANNUAL MEETING P13I

ii

TUESDAY, MAY 19, 1998

Intestinal Disorders AGA Research Forum 8:30-10:00 am Room 88 Ernest N. Morial Convention Center

9:15

Anally projecting neurons from the myenteric p l e x u s p r o v i d e e x c i t a t o r y s y n a p t i c i n p u t s to St y p e s u b m u c o s a l n e u r o n s . (Abstract# G3312) BA Moore and S Vanner. Kingston, Canada

9:30

I n i t i a t i o n of t h e b a l l o o n d i s t e n t i o n - i n d u c e d descending peristaltic reflex in the opossum e s o p h a g u s : r o l e of m u s c l e c o n t r a c t i l i t y . (Abstract# G3319) A Muinuddin and WG Paterson. Kingston, Canada

9:45

Effect of e n d o m o r p h i n - 1 a n d e n d o m o r p h i n - 2 on t h e a s c e n d i n g a n d d e s c e n d i n g reflex p a t h w a y i n r a t i n t e s t i n e . (Abstract# G3131) A Hahn and HD Allescher. Munich, Germany

Chairs: Mrinalini C. Rao, Richard A. Hodin C E L L U L A R A N D M O L E C U L A R BIOLOGY O F T H E ENTEROCYTE 8:45

Na÷/H * e x c h a n g e r NHE3 i n t e r a c t s w i t h PDZ d o m a i n s of t h e r e g u l a t o r y p r o t e i n s , E3KARP a n d NHERF. (Abstract# G1775) CHC Yun, G Lamprecht, EJ Weinman and M Donowitz. Baltimore, MD

9:00

cAMP s t i m u l a t e s p r o t e i n t y r o s i n e p h o s p h o r y l a t i o n i n Ts4 e p i t h e l i a l cells: i m p l i c a t i o n s for c A M P - d e p e n d e n t c h l o r i d e s e c r e t i o n . (Abstract# G1431) LS Bertelsen, SJ Keely and KE Barrett. San Diego, CA

8:30

E G F s t i m u l a t i o n of i l e a l NaCI a b s o r p t i o n r e q u i r e s SRC f a m i l y k i n a s e a c t i v a t i o n of b r u s h b o r d e r P I 3-kinase. (Abstract# G1486) M Donowitz, R Patterson, C Shih and S Khurana. Baltimore, MD

Growth, Development, Nutrition AGA Research Forum 8:30-10:00 am Room 95/96 Ernest N. Morial Convention Center

Chairs: Patrick Tso, Neil LeLeiko NUTRITION: BASIC S C I E N C E 8:30

Cloning a n d f u n c t i o n a l e x p r e s s i o n of t h e h u m a n NRAMP2 i r o n t r a n s p o r t e r . (Abstract# G3751) MT Worthington, E Battle and RQ Lu0. Charlottesville, VA

8:45

P o l y a m i n e s r e g u l a t e SGLT-1 expression. (Abstract# G3650) KI Kr0eker, BM Chung, JA Hardin and DG Gall. Calgary, Canada

9:00

E G F a c u t e l y u p r e g u l a t e s glucose t r a n s p o r t i n t h e j e j u n u m b y i n c r e a s i n g i n s e r t i o n of SGLT-1 into t h e b r u s h - b o r d e r . (Abstract# G3571) BM Chung, JA Hardin and DG Gall. Calgary, Canada

9:15

R e g u l a t i o n of e x p r e s s i o n of t r a n s c o b a l a m i n IIr e c e p t o r i n t h e b a s o l a t e r a l m e m b r a n e s of i n t e s t i n a l e p i t h e l i a l CaCo-2 cells. (Abstract# G3723) B Seetharam, S Seetharam and S Bose. Milwaukee, WI

Motility and Nerve-Gut Interactions AGA Research Forum 8:30-10:00 am Room 89 Ernest N. Morial Convention Center

9:30

L e p t i n r e g u l a t e s t h e i m m u n e system. (Abstract# G3653) FY Lee, SQ Yang, HZ Lin and AM Diehl. Baltimore, MD

Chairs: Gabriel M. Makhlouf, Satish C. Rattan

9:45

F i s h oil d i e t a r y s u p p l e m e n t a t i o n r a p i d l y i n c r e a s e s t h e r e l e a s e of p r o i n f l a m m a t o r y m e d i a t o r s b y h u m a n l e u k o c y t e s . (Abstract# G3583) A Demols, 0 Le M0ine, I Dupont, E Quertinmont, YA Carpentier and J Devi~re. Brussels, Belgium

9:15

I n h i b i t i o n of m y o s i n - b a s e d c y t o s k e l e t a l i n t e r a c t i o n s d i m i n i s h e s i n t e s t i n a l e p i t h e l i a l CI" s e c r e t i o n b y a t t e n u a t i n g Na+/K÷/2C1" c o t r a n s p o r t e r activity. (Abstract# G1588) A Kouts0uris, R Yuhan and G Hecht. Chicago, IL

9:30

P h y s i c a l i n t e r a c t i o n b e t w e e n colon-specific a a n d ~ s u b u n i t s of H,K-ATPase in colonic a p i c a l m e m b r a n e . (Abstract# G1683) P Sangan, VM Rajendran, M Kashgarian and HJ Binder. New Haven, CT

9:45

Cyclic A M P - d e p e n d e n t r e g u l a t i o n of h a p t o g l o b i n b y c o o r d i n a t e i n d u c t i o n of CCAAT/enhancer b i n d i n g p r o t e i n isoforms in i n t e s t i n a l e p i t h e l i a l cells. (Abstract# G1649) N Pelletier, F Boudreau, S Zann0ni, V B0ulanger and C Asselin. Sherbro0ke, Canada

INTRINSIC REFLEXES 8:30

8:45

9:00

P o l a r i z e d reflexes f r o m t h e m y e n t e r i c p l e x u s innervate submucosal vasodilator neurons in g u i n e a p i g ileum. (Abstract# G3501) S Vanner. Kingston, Canada P a r t i c i p a t i o n of g l u t a m a t e r e c e p t o r s i n t h e p e r i s t a l t i c r e f l e x o f t h e g u i n e a p i g d i s t a l colon. (Abstract# G3266) M-T Liu and A Kirchgessner. New York, NY I n h i b i t o r y r e g u l a t i o n of t h e a s c e n d i n g p h a s e of the peristaltic reflex by neuropeptide Y n e u r o n s . (Abstract# G3122) JR Grider. Richmond, VA

AGA State of the Art Lecture 10:30-11:30 am Room 6 4 / 6 5 / 6 6 Ernest N. Morial Convention Center Sponsored by Motility and Nerve-Gut Interactions Co-sponsored b y Growth, D e v e l o p m e n t , N u t r i t i o n The c e l l u l a r a n d m o l e c u l a r b a s i s of H i r s c h p r u n g ' s disease. Michael D. Gershon. New York, NY

P132 PROGRAM OF THE ANNUAL MEETING

GASTROENTEROLOGY Vol. 114~No. 4

TUESDAY, MAY 19, 1998 AGA State of the Art Lecture

I0:30-11:30 am

Room 85/86 Ernest N. Morial Convention Center

Sponsored by Pancreatic Disorders Co-sponsored by Gastrointestinal Oncology

AGA C l i n i c a l S y m p o s i u m 10:30-12:00 p m Room 58 / 59 / 60 Ernest N. Morial Convention Center Sponsored by Immunology,, Microbiology, and Inflammatory Disorders Co-sponsored by Clinical Practice

Chairs: Murray Korc, Paul Urrtia The m o l e c u l a r g e n e t i c s of p a n c r e a t i c c a r c i n o m a . Scott Kern. Baltimore, MD

DDW C o m b i n e d C l i n i c a l S y m p o s i u m 10:30 am-12:00 p m Ballroom A / B Ernest N. Morial Convention Center

Chair:

David B. Sachar

E X T R A I N T E S T I N A L M A N I F E S T A T I O N S O F IBD: DIAGNOSIS, M A N A G E M E N T A N D I N D I C A T I O N S F O R R E F E R R A L O F OCULAR D E R M A T O L O G I C AND R H E U M A T O L O G I C C O M P L I C A T I O N S

S p o n s o r e d by: AGA/ASGE

Eyes. Saras Ramanathan. Chicago, IL

Chairs: Walter Peterson, M. Brian Fennerty

Skin. Jeff P. Callen. Louisville, KY

H. PYLORI: C O N S E N S U S AND CONTROVERSY 10:30

H. pylori, NSAIDs, a n d b l e e d i n g . Neville Yeomans. Footschray, Australia

10:50

Atrophy and atrophic gastritis: an agreement at last? Robert Genta. Houston, TX

11:10

H.p.vlori a n d g a s t r i c cancer.

Joints. Michael H. Ellman. Chicago, IL

AGA C l i n i c a l S y m p o s i u m lO:30-12:00 p m Room 100/101/102 Ernest N. Morial Convention Center Sponsored by Clinical Practice Co-sponsored by Motility and Nerve-Gut Interactions

Julie Parsonnet. Stanford, CA 11:30

H. pylori:, c u r r e n t d i a g n o s i s a n d t r e a t m e n t . Loren Laine. Los Angeles, CA

11:50

Discussion

DDW C o m b i n e d C l i n i c a l S y m p o s i u m 10:30 am-12:00 p m Room 9 0 / 9 1 / 9 2 Ernest N. Morial Convention Center S p o n s o r e d by: ASGE/AGA/SSAT

Chairs: Blair S. Lewis, Donald C. Rockey OCCULT GI B L E E D I N G Attendees will learn about appropriate diagnostic tests to evaluate patients with occult GI bleeding and iron deficiency. New information about medical hormonal therapies, endoscopic therapy and the role of surgery will be discussed. 10:30

I n t r o d u c t i o n a n d overview. Donald C. Rockey. Durham, NC

10:40

D i a g n o s t i c a p p r o a c h to t h e p a t i e n t w i t h occult GI b l e e d i n g . John Morris. Glasgow, Scotland

10:55

E v a l u a t i o n of i r o n d e f i c i e n c y a n e m i a a n d fecal o c c u l t blood. Donald C. Rockey. Durham, NC

11:10

H o r m o n a l a n d o t h e r t h e r a p i e s in p a t i e n t s w i t h o c c u l t GI b l e e d i n g . Blair S. Lewis. New York, NY

11:25

To o p e r a t e o r n o t i n p a t i e n t s w i t h o c c u l t GI bleeding. Brian Katz. New York, NY

11:40

Discussion

Chair:

John F. Johanson

A N O R E C T A L D I S E A S E IN C L I N I C A L P R A C T I C E Overview i n c l u d i n g c l i n i c a l f e a t u r e s . John F. Johanson. Rockford, IL Diagnostic approaches. Michael A. Kamm. Middlesex, England Hemorrhoidal disease - diagnosis, nonoperative t r e a t m e n t , a n d i n d i c a t i o n s for s u r g e r y . Richard L. Nelson. Chicago, IL Fecal incontinence - clinical presentation, diagnostic e v a l u a t i o n , t r e a t m e n t options. James W. Fleshman. St. Louis, MO Questions a n d Answers.

AGA R e s e a r c h S y m p o s i u m 10:30-12:00 p m Room 97/98 Ernest N. Morial Convention Center Sponsored by Intestinal Disorders

Co-sponsored by Immunology, Microbiology, and Inflammatory Disorders TIGHT J U N C T I O N S : M O L E C U L A R R E G U L A T I O N AND I N V O L V E M E N T I N I N T E S T I N A L P A T H O L O G Y

Molecular b a s i s for r e g u l a t i o n o f t h e t i g h t j u n c t i o n . James M. Anderson Modulation of intestinal tight junction by enteric bacterial pathogens. Gaff A. Hecht. Chicago, IL I n vivo p e r m e a b i l i t y m e a s u r e m e n t s a n d i n t e s t i n a l disease. Jonathan B. Meddings. Calgary, Canada

PROGRAM OF THE ANNUAL MEETING P133

April 1998

II

TUESDAY, MAY 19, 1998

AGA Research Symposium

AASLD Research Forum

10:30-12:00 p m

10:30-12:00 p m

Room 99 Ernest N. Morial Convention Center

Sponsored by Esophageal, Gastric and Duodenal Disorders Co-sponsored by Immunology, Microbiology, and Inflammatory Disorders

Chairs: Snorri Thorgeisson, Gregory J. Gores GROWTH AND APOPTOSIS 10:30

The m i t o c h o n d r i a l p e r m e a b i l i t y t r a n s i t i o n is d o w n s t r e a m from FADD a n d caspase l-like proteases, a n d u p s t r e a m from caspase 3-like proteases d u r i n g TNF-a-mediated apoptosis i n hepatocytes. (Abstract# L0065) CA Bradham, T Qian, K Streetz, JJ Lemasters and DA Brenner. Chapel Hill, NC

10:45

Ectopic e x p r e s s i o n of bcl-xL i n liver cell lines p a r a d o x i c a l l y e n h a n c e s apoptosis i n d u c e d by m i t o c h o n d r i a l complex III i n h i b i t o r s . (Abstract# L0647) S Tzung and DM H0ckenbery. Seattle, WA

11:00

Inhibition of cathepsin B by cystatin A reduces bile salt- b u t not staurosporine-induced apoptosis i n a r a t hepatoma cell line. (Abstract# L0280) BA Jones, PJ Roberts, SF Br0nk, E Kominami, LB Agell0n and GJ Gores. Tokyo, Japan; Edmonton, Canada and Rochester, MN

11:15

Alterations i n Fas a n d Fas l i g a n d expression i n c h o l a n g i o c a r c i n o m a : a m e c h a n i s m of escape from i m m u n o s u r v e i l l a n c e . (Abstract# L0519) FG Que, VA Phan, VH Phan, NF LaRusso and GJ Gores. Rochester, MN

11:30

C a l c i n e u r i n is a k e y enzyme i n the d i f f e r e n t i a t i o n of h u m a n h e p a t o m a cells i n d u c e d by s o d i u m b u t y r a t e . (Abstract# L0158) H Ebinuma, H Saito, K Wakabayashi, M Takahashi, F Kaneko, M Nakamura, I Satoh and H Ishii. Tokyo and Tochigi, Japan

11:45

Differential e x p r e s s i o n of m e t h i o n i n e a d e n o s y l t r a n s f e r a s e genes affects the r a t e of growth of h u m a n liver c a n c e r cells: possible m e c h a n i s m s . (Abstract# L0399) Z Ma0, J Cai and SC Lu. Los Angeles, CA

Chair: Byron L. Cryer T H E ROLE OF COXo2 AND NITRIC OXIDE IN MUCOSAL PATHOPHYSIOLOGY The role of n i t r i c oxide i n g a s t r o i n t e s t i n a l mucosal pathophysiology. Brendan Whittle, Jr. London, England P o t e n t i a l t h e r a p e u t i c roles for n i t r i c oxide-releasing NSAIDs. John Wallace. Calgary, Canada Role of COX-2 i n g a s t r o i n t e s t i n a l m u c o s a l pathophysiology. Denis McCarthy. Albuquerque, NM AASLD Research Forum

10:30-12:00 p m

Room 80/81 Ernest N. Morial Convention Center

Chairs: Guadalupe Garcia-Tsao, Andrew Klein PORTAL H Y P E R T E N S I O N : CLINICAL RESEARCH 10:30

De novo d e v e l o p m e n t of esophageal varices i n p a t i e n t s w i t h a r e c e n t histologic diagnosis of l i v e r cirrhosis. (Abstract# L0516) M Primignani, R Alb~, P Preatoni, P Carnevale, MB Bianchi, ML Parravicini, E Del Ninno and R de Franchis. Milan, Italy

10:45

T r a n s j u g u l a r i n t r a h e p a t i c portosystemic s t e n t s h u n t v e r s u s endoscopic b a n d i n g i n the p r e v e n t i o n of v a r i c e a l rebleeding: final r e s u l t s of a r a n d o m i z e d study. (Abstract# L0558) P Sauer, C Benz, L Theilmann, G Richter, W Stremmel and A Stiehl. Heidelberg, Germany

11:00

E n d o s c o p i c f i n d i n g s p r e d i c t b l e e d i n g from p o r t a l h y p e r t e n s i v e gastropathy: v a l i d a t i o n of a PHG s c o r i n g system. (Abstract# L0606) CA Stewart and AJ Sanyal. Richmond, VA

11:15

G a s t r i c v a s c u l a r ectasia do n o t improve w i t h r e d u c t i o n of p o r t a l p r e s s u r e b y t r a n s j u g u l a r i n t r a h e p a t i c p o r t o s y s t e m i c s h u n t s . (Abstract# L0284) PS Kamath, MA Lacerda, DA Ahlquist, JC Andrews, MA McKusick and DM Nagorney. Rochester, MN

11:30

E v a l u a t i o n of m u l t i o r g a n failure as risk factor for e a r l y m o r t a l i t y after TIPS: bedside s c o r i n g v e r s u s APACHE-II score i n more t h a n 100 p a t i e n t s . (Abstract# L0071) KA Brensing, P Raab, J Texter, P Schiedermaier, WD Paar, H Strunk, H Schild and T Sauerbruch. Bonn, Germany

11:45

F u r o s e m i d e - i n d u c e d n a t r i u r e s i s as a test to identify cirrhotic patients with refractory ascites. (Abstract# L0601) L Spahr, HK Tran, JP Villeneuve and G P0mierLayrargues. Montreal, Canada and Geneva, Switzerland

Room 82/83 Ernest N. Morial Convention Center

G A S T R O E N T E R O L O G Y Vol. 114~No. 4

P134 P R O G R A M OF THE ANNUAL M E E T I N G

II

TUESDAY, MAY 19, 1998 Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum

10:30-12:00 p m

11:00

Intravenous trimebutine shortens the duration of c a t h e t e r i z a t i o n of the d u o d e n a l papilla. Results of a c o n t r o l l e d d o u b l e - b l i n d study. (Abstract# G2152) H Lamouliatte, A Roche and C Pecout. Bordeaux and Fresnes, France

11:15

S u p p r e s s i o n of d u o d e n a l m o t i l i t y d u r i n g ERCP b y L-hyoscyamine v e r s u s glucagon: a r a n d o m i z e d , prospective, d o u b l e - b l i n d e d trial. (Abstract# G2177) PL Moses, 0 Alkhatib, R Mitty, N Ferrentino, R Rothstein, PW Callas and JA Vecchio. Burlington, VT; Boston, MA and Lebanon, NH

11:30

A prospective controlled evaluation of MI~ cholangiopancreatography i n patients with suspected bile duct obstruction. (Abstract# G2094) HE Adamek, M Weitz, H Breer, J Albert, R Jakobs and JF Riemann. Ludwigshafen, Germany

11:45

More t h a n 10-year long t e r m r e s u l t s of endoscopic s p h i n c t e r o t o m y for c o m m o n bile duct stones i n 446 patients. (Abstract# G2164) H Matsunaga, T Nabae, H Niiyama, S Takahata, N Utsunomiya, K Yokohata and M Tanaka. Fukuoka, Japan

Room 11 Ernest N. Morial Convention Center

Chairs: Richard P. MacDermott, Matthew B. Grisham M E C H A N I S M S OF MUCOSAL I M M U N I T Y AND INFLAMMATION 10:30

I d e n t i f i c a t i o n of b o t h CD2 e n h a n c e r a n d r e p r e s s o r e l e m e n t s w i t h i n the interferon-T p r o m o t e r w h i c h r e g u l a t e c y t o k i n e secretion i n l a m i n a p r o p r i a T cells. (Abstract# G4043) R G0nsky, RL Deem, HA Young and SR Targan. Los Angeles, CA and Frederick, MD

10:45

D i s t i n c t m o l e c u l a r m e c h a n i s m s r e g u l a t e the d i f f e r e n t i a l e x p r e s s i o n of the c h e m o k i n e s ENA78 & IL-8 i n CaCo-2 cells. (Abstract# G4123) AC Keates, S Keates, K O'Dell and CP Kelly. Boston, MA

11:00

V i t a m i n E p r e t r e a t m e n t of h u m a n i n t e s t i n a l m i c r o v a s c u l a r e n d o t h e l i a l cells i n h i b i t s leukocyte adhesion: a t h e r a p e u t i c role for antioxidants in intestinal inflammation? (Abstract# G3824) DG Binion, YC Chai, JA Drazba, JG Wade and KT Wilson. Milwaukee, WI; Cleveland, OH and Baltimore, MD

11:15

Mucosal i n f l a m m a t i o n i n a genetic model of type I diabetes. (Abstract# G3965) L Donegan, JA Hardin and DG Gall. Calgary, Canada

11:30

IL-17 synergizes w i t h IL-I~ i n the i n d u c t i o n of c h e m o k i n e e x p r e s s i o n i n i n t e s t i n a l epithelial cells. (Abstract# G3789) M Awane, PG Andres, RP MacDerm0tt, DK Podolsky and HC Reinecker. Boston, MA and Burlington, MA

11:45

LPS i n d u c e s u p r e g u l a t i o n of CD14 expression a n d t y r o s i n e p h o s p h o r y l a t i o n of a 40 kDa p r o t e i n i n a n i n t e s t i n a l e p i t h e l i a l cell line. (Abstract# G3855) "SL Brandwein, HC Reinecker and DK Pod01sky. Boston, MA

Biliary Disorders AGA Research Forum

10:30-12:00 p m

Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum

10:30-12:00 p m

Chairs: Lloyd F. Mayer, Martin Zeitz P A T H O G E N E S I S OF CROHN'S DISEASE 10:30

Mice c a r r y i n g a n e n d o g e n o u s d e l e t i o n of the 3'AU-rich r e g i o n of the TNFa gene develop a Crohn's disease-like p h e n o t y p e : a k e y role of the TNF-a i n the p a t h o g e n e s i s of c h r o n i c i n t e s t i n a l i n f l a m m a t i o n . (Abstract# G3911) F C0minelli, D K0ntoyiannis, TT Pizarro and G Kollias. Charlottesville, VA and Athens, Greece

10:45

The role of TNF-~ i n Crohn's disease: TNF-am e d i a t e d a u g m e n t a t i o n of LPMC IFN-y p r o d u c t i o n is IL-12 a n d IL-18 i n d e p e n d e n t . (Abstract# G4355) J Prehn, SE Plevy, CJ Landers and SR Targan. Los Angeles, CA

lh00

IL-18, a novel i m m u n o r e g u l a t o r y cytokine, is u p r e g u l a t e d i n Crohn's disease: e x p r e s s i o n a n d localization i n i n t e s t i n a l m u c o s a l cells. (Abstract# G4347) TT Pizarro, M Huybrechts, M Bentz, E Foley, CA Moskaluk, SJ Bickston and F Cominelli. Charlottesville, VA

11:15

T cells e x p a n d e d i n v/tro b y a n t i g e n s from the i n t e s t i n a l flora are p r e s e n t i n i n v o l v e d Crohn's disease mucosa. (Abstract# G4238) E May, W Holtmeier, A Hennemann, KH Meyer zum Bfischenfelde and r Duchmann. Mainz and Frankfurt, Germany

11:30

Fas- a n d CD45RO-negative T cells c o n t r i b u t e to mucosal T cell r e s i s t a n c e to apoptosis i n Crohn's disease. (Abstract# G4U0) J Itoh, AD Levine and C Fi0cchi. Cleveland, OH

11:45

Esophageal e p i t h e l i u m i n C r o h n ' s disease: HLA-DR e x p r e s s i o n - a d i a g n o s t i c s i g n of microscopic disease? (Abstract# G4310) G Oberhuber, A Piisp0k, M Peck-Radosavlevic, M Kutilek, A Lamprecht, A Chott, H Vogelsang and M Stolte. Vienna, Austria and Bayreuth, Germany

Room 13 / 15 / 17 Ernest N. Morial Convention Center

Chairs: Richard I. Rothstein, Franco Bazzoli D I A G N O S I S AND T R E A T M E N T OF BILIARY DISEASE 10:30

P h o t o d y n a m i c t h e r a p y of non-resectable cholangiocellular carcinoma. (Abstract# G2187) M Ortner, J Liebetruth, A Giesse, M Hanft, J Weber, J Wirth and H Lochs. Berlin, Germany

10:45

A c o m p a r i s o n of formal b i l i a r y drainage a n d endoscopic b i l i a r y d r a i n a g e i n the diagnosis of microcalculous gallbladder disease. (Abstract# G2149) D Kossoff, A Thomas, D Brodmerkel, R Agrawal and G Brodmerkel, Jr. Pittsburgh, PA

Room 19 Ernest N. Morial Convention Center

April 1998

P R O G R A M OF T H E A N N U A L M E E T I N G P135

TUESDAY, MAY 19, 1998 Gastrointestinal Oncology AGA Research Forum

10:30-12:00 p m

10:50

t i g h t j u n c t i o n i n j u r y i n c a n i n e gastric m u c o s a monolayers. (Abstract# G0364) MC Chen, HT Yang, JH Walsh and AH Soll. Los Angeles, CA

Room 33/35 Ernest N. Morial Convention Center

Chairs: Peter R. Holt, Gary A. Piazza

11:00

Discussion

11:05

M a t r i x - d e p e n d e n t t y r o s i n e p h o s p h o r y l a t i o n of focal a d h e s i o n p r o t e i n s m a y r e g u l a t e h u m a n (CaCo-2) e n t e r o c y t e s p r e a d i n g a n d motility. (Abstract# GU30) MA Sanders and MD Basson. New Haven, CT Discussion

M E C H A N I S M S OF APOPTOSIS 10:30

10:45

11:00

Apoptosis a n d morphological changes i n d u c e d b y l o v a s t a t i n i n IEC-18 cells are i n h i b i t e d by cycloheximide. (Abstract# G2486) B Halmos, B Agarwal, WG Ramey, SF Moss and PR Holt. New York, NY Heterologous e x p r e s s i o n of the pro-apoptotic gene b~de i n ras t r a n s f o r m e d enterocytes r e s u l t s i n p a r t i a l r e v e r s i o n of t h e i r t r a n s f o r m e d p h e n o t y p e . (Abstract# G2497) : N Harris, D Kaznov, M Moshkowitz, M Shaked, N Paweletz, D Schroeter, J Ratan, J Reed, P Holt, B Weinstein and N Arber, Tel Aviv, Israel; Heidelberg, Germany; La Jolla, CA and New York, NY C-K-ras transformed rat enterocytes are more sensitive t h a n n o r m a l enterocytes (IEC18) to growth inhibition a n d apoptosis induced by sulindac sulfone a n d nimesulid. (Abstract# G2496) N Harris, D Kaznov, M Pick, V Deutsch, N Paweletz, GA Piazza, D Ahnen, R Pamukcu, P Holt, IB Weinstein and N Arber. Tel Aviv, Israel; Heidelberg, Germany; Philadelphia, PA and New York, NY

11:15

NSAIDs may reactivate the adenomatous polyposis coli p a t h w a y to apoptosis. (Abstract# G2552) J Kelloff, T Maltzman, G Piazza and D Ahnen. Denver, CO and Philadelphia, PA

11:30

P y r r o l i d i n e d i t h i o c a r b a m a t e r e d u c e s the cytotoxic a c t i o n of 5-fluorouracil i n n o r m a l m u r i n e small i n t e s t i n e : the roles of p53, p32 a n d C/EPB[L (Abstract# G2371) R Chinery, RJ Coffey, RD Beauchamp, CS Potten and AJM Watson: Nashville, TN and Manchesterl United Kingdom

11:45

A n t i o x i d a n t - i n d u c e d association of C C A A T / e n h a n c e r - b i n d i n gp r o t e i n [~(C/EBP~) w i t h a n A-kinase a n c h o r i n g p r o t e i n m u l t i e n z y m e complex facilitates type II Akinase-mediated phosphorylation and nuclear t r a n s l o c a t i o n of C/EBP~. (Abstract# G2370) R Chinery, RJ Coffey and DT Dransfield. Nashville, TN and Augusta, GA

11:15 11:20

M e c h a n i s m s of a d a p t a t i v e p r o t e c t i o n a n d t o l e r a n c e to i n j u r y . Thomas A. Miller. St. Louis, MI

11:30

Adaptive c y t o p r o t e c t i o n i n d u c e d b y deoxycholate i n h u m a n gastric cells is c a l c i u m (Ca2*)-mediated. (Abstract# G0751) ER Kokoska, GS Smith, AB Wolff, Y Deshpande and TA Miller. St Louis, MO Gastric m u c o s a r e p e a t e d l y exposed to Helicobacter pylori l i p o p o l y s a c c h a r i d e shows i n c r e a s e d t o l e r a n c e to i n j u r y via iNOS, COX-2 a n d HSP 70 m e c h a n i s m s . (Abstract# G0765) PC Konturek, T Brzozowski, SJ Konturek, A Taut, P Pierzchalski and EG Hahn. Erlangen, Germany and Krakow, Poland Discussion

11:40

11:50

Gastrointestinal Oncology AGA Research Forum

10"30:12:00 p m

Room 38 Ernest.N. Morial Convention Center

COLON CANCER S C R E E N I N G 10:30

10:45

11:00

11:15

Chairs: Thomas A. Miller, Marc D. Basson M E C H A N I S M S OF MUCOSAL INJURY AND ADAPTATION 10:30

10:40

Extrocellate matrix, cytoskeleton, a n d growth factors i n m u c o s a l i n j u r y a n d r e p a i r . Marc D. Basson. New Haven, C T E t h a n o l m o d u l a t i o n of t i g h t j u n c t i o n b a r r i e r . (Abstract# G0855) TY Ma, D Nguyen, N Hoa, H Nguyen and V Bui. Long Beach and Irvine, CA

Room 4 1 / 4 2 / 4 3 Ernest N. Morial Convention Center

Chairs: David A. Ahlquist, Yaron Niv

Esophageal, Gastric, and Duodenal Disorders AGA Research Forum

10:30-12:00 p m

Helieobaeterpj~lori u r e a s e a c t i v i t y i n d u c e s

11:30

11:45

On-site flexible sigmoidoscopy positively influences colorectal cancer s c r e e n i n g practices b y p r i m a r y care providers. (Abstract# G2790) PC Schroy, M Prout, CM Bliss, CM Bliss, Jr, J Pincus, S Wilson and T Herren. Boston, MA A p r i m a r y care s u r v e y of beliefs a n d practices p a t t e r n s r e l a t e d to colorectal c a n c e r screening. (Abstract# G2789) PC Schroy, A Geller, L Sutherland, R Palombo, D Brooks, S Holm, S Supran, M Page and MC Woods. Boston, MA A f u r t h e r e v a l u a t i o n of the n e w i m m u n o chemical fecal occult blood test FlexSure~OBT. (Abstract# G2826) DJB St John, MA Sinatra, GP Young, J Tilkeridis and ]VIAAlexeyeff. Victoria, Australia Accuracy of polyp d e t e c t i o n d u r i n g s c r e e n i n g flexible sigmoidoscopy b y gastroenterologists a n d n u r s e endoscopists: a r a n d o m i z e d c o n t r o l l e d trial. (Abstract# G2786) P Schoenfeld, S Lipscomb, J Dominguez, J Crook, L Holmes, M Piorkowski, J Allaire, M Johnston, J Butler, A Hammond, D Cruess and D Rex. Bethesda, MD and Indianapolis, IN P a t i e n t satisfaction w i t h s c r e e n i n g flexible sigmoidoscopy. (Abstract# G2785) RE Schoen, JL Weissfeld, NJ Bowen and A Baum. Pittsburgh, PA R e d u c i n g the cost of bowel c a n c e r screening. (Abstract# G2457) DJ Frommer and A Woodger. Darlinghurst, Australia

G A S T R O E N T E R O L O G Y Vol. 114 r No. 4

P 1 3 6 P R O G R A M O F T H E A N N U A L MEETING

TUESDAY, MAY 19, 1998 Hormones, Transmitters, Their Receptors AGA Research Forum

10:30-12:00 p m

Growth Factors and

11:00

P h o s p h o t y r o s i n e s i g n a l i n g is r e q u i r e d for a d h e r e n c e of H. pylorl to c u l t u r e d g a s t r i c cells: H. pylorJinteraction w i t h g a s t r i c cells u s i n g Y e r s i n i a as a tool. (Abstract# G4471) B Su, M Patarroyo, M Granstr6m and S N0rmark. Stockholm and Ume~, Sweden

11:15

Use of a n i n f e c t i o u s clone to s t u d y m o l e c u l a r p a t h o g e n e s i s o f h u m a n a s t r o v i r u s . (Abstract# G4034) U Geigenmfiller, NH Ginzton and SM Matsui. Palo Alto and Stanford, CA

11:30

Clostrleb'um vb'fflcile t o x i n - i n d u c e d IL-8 r e l e a s e b y m o n o c y t e s follows t y r o s i n e k i n a s e , NF-KB a n d NF-IL6 a c t i v a t i o n . (Abstract# G4551) M Warny, AC Keates, S Keates, C P0thoulakis and CP Kelly. Boston, MA

11:45

R e d u c t i o n in n e t i o n t r a n s p o r t i n d u c e d b y e n t e r o p a t h o g e n i e E. eoli i n f e c t i o n of i n t e s t i n a l e p i t h e l i a l cells is a t t r i b u t a b l e to b i c a r b o n a t e t r a n s p o r t . (Abstract# G4148) A Kouts0uris and G Hecht. Chicago, IL

Room 44 Ernest N. Morial Convention Center

Chairs: K.C. Kent Lloyd, R a j K. Goyal K N O C K O U T M I C E : L E S S O N S F O R GUT MESSENGER SYSTEMS 10:30

ECL cells a n d g a s t r i c a c i d s e c r e t i o n i n g a s t r i n d e f i c i e n t mice. (Abstract# G4646) D Chen, T Koh, C-M Zhao, R H~kanson and TC Wang. Lund, Sweden and Boston, MA

10:45

Gastric hypersecretion in somatostatin r e c e p t o r s u b t y p e 2 k n o c k o u t mice. (Abstract# G4757) V Martinez, B Torkian, JM Schaeffer, HA Wilkinson, JH Walsh and Y Tachd. Los Angeles, CA and Rahway, NJ

11:00

11:15

11:30

11:45

M e a s u r e m e n t of c o l o r e c t a l m o t i l i t y in a w a k e C57BL/6 m i c e d e f i c i e n t i n t h e C-kit gene: c o m p l e t e s u p p r e s s i o n of colonic a c t i v i t y w i t h n i f e d i p i n e . (Abstract# G3373) MA Pezzone, MO Fraser and WC de Groat. Pittsburgh, PA N o r m a l b r e a s t m i l k l i m i t s t h e d e v e l o p m e n t of colitis i n IL-10 g e n e - d e f i c i e n t mice. (Abstract# G4217) KL Madsen, JS Doyle, MM Tavernini, LD Jeweil, D Gray and RN Fedorak. Edmonton, Canada T a r g e t t e d t r a n s g e n i c a b l a t i o n of goblet cells; p a r a d o x i c a l r e d u c t i o n in s u s c e p t i b i l i t y to d e x t r a n s o d i u m sulfate- a n d a c e t i c acidi n d u c e d e x p e r i m e n t a l colitis. (Abstract# G3625) H Itoh, PL Beck, IM Rosenberg and DK Podolsky. Boston, MA D i m i n i s h e d i n t e s t i n a l i n f l a m m a t o r y and secretory responses in substance P receptor (NK-1R) d e f i c i e n t mice. (Abstract# G4637) I Castagliuolo, A Pasha, C Wang, AC Keates, S Nikulasson, B Lu, NP Gerard, G Gerard and C Pothoulakis. Boston, MA

Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum

10:30-12:00 p m

Esophageal, Gastric, and Duodenal Disorders AGA Research Forum

10:30-12:00 p m

Chairs: James M. Scheiman, Michael J. Langman GI TOXICITY OF NSAIDS: M A G N I T U D E , CAUSE, AND P R E V E N T I O N 10:30

P u b l i c m i s u n d e r s t a n d i n g of n o n s t e r o i d a l antiinflammatory drug-mediated gastrointestinal toxicity: a serious potential h e a l t h t h r e a t . (Abstract# G0555) JL G01dstein and JB Lefk0with. Chicago and Sk0kie, IL

10:45

T h e b u r d e n of u l c e r c o m p l i c a t i o n s a n d d e a t h s a s s o c i a t e d w i t h t h e u s e o f i n d i v i d u a l nons t e r o i d a l a n t i i n f l a m m a t o r y d r u g s . (Abstract# G0801) MJS Langraan. Birmingham, United Kingdom

11:00

I m p a c t of NSAID choice a n d p a t i e n t s y m p t o m s on t h e cost-effectiveness of s t r a t e g i e s to p r e v e n t NSAID g a s t r o p a t h y . (Abstract# G0492) AM Fendrick, R Bandekar, ME Chernew and JM Scheiman. Ann Arbor, MI

11:15

Clinical t r i a l of b o v i n e c o l o s t r u m f o r protection against NSAID-induced e n t e r o p a t h y . (Abstract# G0856) CE Macdonald, DP Calnan, T Podas, W Johnson and RJ Playford. Leicester and Liverpool, United Kingdom

11:30

R e d u c e d p e r f o r a t i o n s , ulcers, b l e e d s a n d h o s p i t a l i z a t i o n for GI a d v e r s e e v e n t s w i t h m e l o x i c a m c o m p a r e d to d i c l o f e n a c a n d p i r o x i c a m . (Abstract# G0597) CJ Hawkey. Nottingham, United Kingdom

11:45

H e a t shock p r o t e i n 70 i n g a s t r i c m u c o s a l d a m a g e a n d a d a p t a t i o n ; effects of Helicobacter pyloriinfection. (Abstract# G0501) H Fischer, PC Konturek, V Huber, J Neumann, EG Hahn, W Schmitz, W Domschke and JW Konturek. Muenster and Erlangen, Germany

Room 89 Ernest N. Morial Convention Center

Chairs: Charalabos Pothoulakis, Ellen Li MICROBIAL PATHOGENESIS 10:30

Giardla lm~blia i n f e c t i o n of h u m a n i n t e s t i n a l e p i t h e l i a l cell c u l t u r e s i n h i b i t s e p i t h e l i a l n i t r i c oxide p r o d u c t i o n . (Abstract# G3977) L Eckmann, F Laurent, FD GiUin and MF Kagnoff. La Jolla, CA

10:45

H I V - i n d u c e d c y t o k i n e s of h u m a n i m m u n e cells i m p a i r i n t e s t i n a l e p i t h e l i a l b a r r i e r function. (Abstract# (34420) H Schmitz, K Rokos, H Bode, M Fromm, P Scholz, EO Riecken, G Pauli and JD Schulzke. Berlin, Germany

Room 93/94 Ernest N. Morial Convention Center

A p r i l 1998

P R O G R A M O F T H E A N N U A L M E E T I N G P137

TUESDAY, MAY 19, 1998 Intestinal Disorders AGA Research Forum

10:30-12:00 p m

11:00

P r e v e n t i o n of a n t i b i o t i c - a s s o c i a t e d d i a r r h e a u t i l i z i n g Laetobacillus GG. (Abstract# G1773) RJ Young, DB Whitney, TL Hanner, DL Antonson, JV Lupo and JA Vanderhoof. Omaha, NE

11:15

S p l a n c h n i c i s c h e m i a is a s s o c i a t e d with increased intestinal permeability, endotoxemia and bacteremia in general i n t e n s i v e care p a t i e n t s b u t n o t i n acute liver failure, (Abstract# G1514) SM Gabe, M Patel, GK Grimble, GR Barclay, R Williams, I Bjarnason and DBA Silk. London, United Kingdom

11:30

Reduced mesenteric arterial norepinephrine r e p o n s i v e n e s s i n p o r t a l h y p e r t e n s i v e r a t s is e n d o t h e l i a l i n d e p e n d e n t . (Abstract# G1558) Z Jiao and JN Benoit. Mobile, AL

11:45

Two h i t model of i n t e s t i n a l ischemiar e p e r f u s i o n : t i m i n g n o t s e v e r i t y of the second h i t causes gut a n d l u n g i n j u r y . (Abstract# G1515) CM Gallagher, WC Conner, H Tavaf-Motamen, T Miner and T Shea-Donohue. Washington, DC and Bethesda, MD

Room 95/96 Ernest N. Morial Convention Center

Chairs: Robert M. Craig, Gary R. Lichtenstein CLINICAL ADVANCES IN INTESTINAL DISORDERS II 10:30

10:45

I n c r e a s e d n e u r o t e n s i n r e c e p t o r mRNA i n colonic m u c o s a of p a t i e n t s with i r r i t a b l e bowel disease. (Abstract# G1456) I Castagliuolo, A Lembo, A Pasha and C Pothoulakis. Boston, MA Heo-colonic l y m p h o n o d u l a r hyperplasia, n o n specific colitis a n d a u t i s t i c s p e c t r u m d i s o r d e r i n c h i l d r e n : a n e w s y n d r o m e ? (Abstract# G1753) AJ Wakefield, SH Murch, A Anthony, J Linnell, DM Casson, M Malik, M Berelowitz, AP Dhillon, MA Thomson, P Harvey, A Valentine, SE Davies and JA Walker-Smith. London, United Kingdom

P138 PROGRAM OF THE ANNUAL MEETING

GASTROENTEROLOGYVoL 114~No. 4

MEET-THE-PROFESSOR/MEET-THE-INVESTIGATORLUNCHEONS 12:30 P M t o 1:45 P M

MEET-THE-INVESTIGATOR LUNCHEONS 45 46

Anna Mae Diehl Jackie D. Wood

47

David H. Alpers

48

Henry J. Binder

Regulation ofhepatocyte proliferation How the immune system communicates with the enteric nervous system The relevance of intestinal cell models to study the intact organ Short chain fatty acids: bench to bedside MEET-THE-PROFESSOR

49 50 51 52 53 54 55 56 57 58 59 60 61 62 62A 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86

87 88 89

Prevention of colorectal cancer: scopes and hopes Evaluation of idiopathic pancreatitis Liver transplantation in alcoholics Pediatric liver disease IBD subtypes: therapeutic implications GERD: managing the resistant patient Management of complex esophageal strictures Managed care for the gastroenterologist ERCP: how to be dual selective A survival guide to private practice Extraintestinal manifestations in inflammatory bowel disease Eugene P. DiMaguo Treatment of chronic pancreatitis Steven A. Edmundowicz Endoscopic ultrasonography: the basics for beginners Outcomes research for practicing physicians James T. Frakes John F. Johanson NIH funding: the successful grant application Kenneth Forde Challenging cases Lawrence S. Friedman Guadalupe Garcia-Tsao Infectious complications of cirrhosis Prevention and treatment ofvariceal hemorrhage Norman D. Grace Ascites: spontaneous bacterial peritonitis J. Eileen Hay Inflammatory bowel disease management Stephen B. Hanauer New insights into therapy for hepatitis C Jay H. Hoofnagle Outcomes research for practicing physicians John F. Johanson New options for obesity: drugs versus operations John G. Kral Practical computer applications for the Benjamin Krevsky gastroenterologist's office Photodynamic therapy Charles J. Lightdale Dyspepsia: treat or investigate first? Juan R. Malagelada Selection and timing for liver transplantation Santiago J. Munoz Management of esophageal strictures H. Juergen Nord New directions in antiviral treatment of Robert P. Perrillo chronic viral hepatitis Current controversies in colon cancer screening David F. Ransohoff A practical approach to Barrett's James C. Reynolds Extraesophageal presentations of Joel E. Richter gastroesophageal reflux disease Laparoscopic management of CBD stones Nathaniel J. Soper Barrett's esophagus Stuart Spechler Endoscopic treatment of varices Gregory V. Stiegmann IBD: the next millennium Stephen R. Targan Hemochromatosis Anthony S. Tavill The role of minimally invasive surgery in the Lawrence Way treatment of esophageal diseases Management of GERD: can surgeons and John G. Hunter gastroenterologists agree? J. Patrick Waring

Raj Goyal David Lichtenstein Michael Weinstein

Crescent

Sheraton

Edgewood

Sheraton Sheraton

Bonnie Burn Ellendale

LUNCHEONS

Dennis J. Ahnen John Baillie John A. Balint William F. Balistreri Theodore A. Bayless Stanley B. Benjamin H. Worth Boyce Martin Brotman John P. Cello Sarkis J. Chobanian Kiron M. Das

AGA PROBLEM-BASED

Sheraton

Convention Center Convention Center Convention Center Marriott Convention Center Convention Center Convention Center Convention Center Convention Center Marriott

Room 20 Room 22 Room 24 Jackson Room 23 Room 25 Room 27 Room 29 Room 31 Chartras

Convention Center Convention Center

Room 26 Room 36

Convention Center Sheraton

Room 39 St Charles B

Marriott Marriott Marriott Marriott Sheraton Sheraton Sheraton Sheraton Sheraton

Balcony I/J Balcony L Balcony N Balcony M Esterwood Evergreen Felicity Gallier House Oakley

Sheraton Sheraton Sheraton Sheraton Sheraton

Rosella Southdown Bayside A Suite 816 Suite 5

Sheraton Sheraton Sheraton

Suite 820 Suite 821 Suite 824

Sheraton Sheraton Sheraton Marriott Marriott Marriott

Suite 825 Suite 828 Suite 829 Bonaparte Regent Bacchus

Marriott Marriott

Iberville Balcony K

LEARNING SESSIONS

Scleroderma esophagus Gallstone pancreatitis with massive necrosis Evaluating speciality capitation rates

Marriott Marriott Marriott

Audubon Beauregard Galvez

April 1998

PROGRAM OF THE ANNUAL MEETING P139

A G A P O S T E R S E S S I O N - - T U E S D A Y , M A Y 19, 1998 AGA Poster Session

8:00-5:00 p m

Hall D Ernest N. Morial Convention Center

Authors are required to present during the Poster Session from 12:00-2:30 pm

DDW Poster of Distinction: Clostridium eb'fflcilc t o x i n s A a n d B i n s y m p t o m a t i c p a t i e n t s at a t e r t i a r y p e d i a t r i c hospital. (Abstract# G0085) HA Kader, DA Piccoli, AF Jawad, KL McGowan and ES MaUer. PhiladelPhia, PA

Those posters identified as DDW Posters of Distinction have received review scores that place them within the top 10% of all posters. We encourage you to make them a priority as you visit the poster session.

U n e x p l a i n e d leukocytosis as a h a r b i n g e r a n d s u r r o g a t e m a r k e r of ClostrleHum difflcile i n f e c t i o n i n hospitalized p a t i e n t s w i t h diarrhea. (Abstract# G0022) M Bulusu and G Triadafilopoulos. Palo Alto and Stanford, CA

CLINICAL PRACTICE - - II

Late o n s e t u l c e r a t i v e colitis: a n a l y s i s of clinical outcome a n d t h e r a p e u t i c response. (Abstract# G0182) AS Taha and AY Taha. Eastbourne, United Kingdom

Is it possible to simplify the d e f i n i t i o n of the i r r i t a b l e bowel s y n d r o m e i n p o p u l a t i o n - b a s e d studies a n d clinical p r a c t i c e ? (Abstract# G0003) L Agreus, NJ Talley, K Sv~rdsudd, 0 Nyr~n, G Tibblin and MP Jones. Uppsala and Stockholm, Sweden; Sydney, Australia C h r o n i c a b d o m i n a l p a i n : t h e d i a g n o s t i c value of a c o m b i n e d c l i n i c a l a n d p a i n m a n a g e m e n t approach. (Abstract# G0171) EE Softer, GY Kunze, D Conwell, E Yap and N Mekhail. Cleveland, OH

A c o m p u t e r d a t a s t r u c t u r e for i n f l a m m a t o r y bowel disease h i s t o p a t h o l o g y reports. (Abstract# G0200) K Wilkinson, C Price, A Solomonides and A Forbes. Bristol and Harrow, United Kingdom Long t e r m outcome of p a t i e n t s after IPAA for u l c e r a t i v e colitis. (Abstract# G0094) J Kuisma, H Nuutinen, H J~rvinen, P Luukkonen, A Kahri and M F~irkkil~L Helsinki, Finland

I n t e r n a t i o n a l economic i m p a c t of f u n c t i o n a l g a s t r o i n t e s t i n a l disorders. (Abstract# G0058) S Fullerton and EA Mayer. Los Angeles, CA

Results of t r a n s c u t a n e o u s u l t r a s o u n d s c a n i n i n f l a m m a t o r y a n d infectious diseases of t h e sigmoid colon. (Abstract# G0101) JC Letard, F Cessot, D Rousseau, JM Nivet, M Mendler, D Sautereau and B Pillegand. Poitiers and Limoges, France

P r e v a l e n c e of e x t r a i n t e s t i n a l s y m p t o m s i n p a t i e n t s w i t h i r r i t a b l e bowel s y n d r o m e a n d i n f l a m m a t o r y bowel disease. (Abstract# G0059) S Fullerton, P Anton, L Chang, B Naliboff, CN Bernstein and EA Mayer. Los Angeles, CA and Manitoba, Canada

Histogenesis of p s e u d o c a r c i n o m a t o u s i n v a s i o n i n p e d u n c u l a t e d colon polyps. (Abstract# G0178) C Subramony, W May, R Joseph and A Mihas. Jackson, MS

G e n d e r specific p r e d i c t o r s of h e a l t h care u t i l i z a t i o n for p a t i e n t s w i t h i r r i t a b l e bowel syndrome. (Abstract# G0057) S Fullerton, B Naliboff and EA Mayer. Los Angeles, CA D e v e l o p m e n t a n d v a l i d a t i o n of a q u a l i t y o f life tool for i r r i t a b l e bowel syndrome. (Abstract# G0039) W Depew, S Vanner, W Paterson, N Roblin, D Groll, T MacKenzie, L Da Costa, A Groll and J Simon. Kingston, Canada M e a s u r i n g quality-of-life i n c h r o n i c constipation. (Abstract# G0042) DJ Dubois, KI Johnson, C de la Loge and P Marquis. Belgium, United Kingdom and France S e r u m m a g n e s i u m levels a n d u r i n a r y m a g n e s i u m e x c r e t i o n i n p a t i e n t s w i t h c h r o n i c constipation, (Abstract# G0028) JA Clark, M Robinson and PB Miner, Jr. Oklahoma City, OK A large US n a t i o n a l epidemiological s t u d y of c o n s t i p a t i o n . (Abstract# G0177) WF Stewart, JN Liberman, RS Sandler, MS Woods, A Stemhagen and CE Farup. Chapel Hill, NC and Titusville, NJ T r e a t m e n t of c h r o n i c a b d o m i n a l p a i n of obscure etiology: effectiveness of c h r o n i c p a i n m a n a g e m e n t c e n t e r referral. (Abstract# G0137) D Peters, C Thompson, S McGarrity and T McGarrity. Hershey, PA Digestive disease q u a l i t y of life i n s t r u m e n t (DDQ-15): a v a l i d a t i o n study. (Abstract# G0133) YY Palesch, RL Hebert, LK McDaniel, PR Tarnasky, PD Mauldin and PB Cotton. Charleston, SC

The effect of s m o k i n g a n d d r i n k i n g alcohol on the i n c i d e n c e of a d e n o m a t o u s polyps of t h e left colon. (Abstract# G0107) CP Macklin, T Cecil, M Watson, J Martin, PJ Finan and DT Bishop. Manchester and London, United Kingdom C h a n g i n g d e m o g r a p h i c s of colorectal cancer: a 15-year experience. (Abstract# G0162) VK Sharma, R Vasudeva and CW Howden. Columbia, SC Strategy a n d p r o b l e m s i n t r e a t m e n t of g a s t r o i n t e s t i n a l obstruction in patients with unresected/uncured a d v a n c e d cancer. (Abstract# G0180) Y Suzuki, N Hanyu, N Takahashi, K Sate and T Aoki. Tokyo, Japan S e r u m a n t i o x i d a n t s a n d t h e r i s k of colorectal adenomas. (Abstract# G0021) B Breuer-Katschinski, K Nemes, B Rump, B Leiendecker, A Marr, N Breuer, H Goebell and the Colorectal Polyp Study Group. Essen, Germany Glyceryl t r i n i t r a t e heals a n a l fissures; h i g h doses do it q u i c k e r b u t there is a h i g h r e c u r r e n c e rate. (Abstract# G0026) EA Carapeti, MA Kamm and RKS Phillips. Harrow, United Kingdom Diltiazem lowers r e s t i n g a n a l s p h i n c t e r p r e s s u r e - a p o t e n t i a l low side-effect a l t e r n a t i v e to glyceryl t r i n i t r a t e for fissures. (Abstract# G0025) EA Carapeti, MA Kamm, BK Evans and RKS Phillips. Harrow, United Kingdom Topical p h e n y l e p h r i n e i n c r e a s e s a n a l s p h i n c t e r r e s t i n g p r e s s u r e - a possible t r e a t m e n t for fecal i n c o n t i n e n c e . (Abstract# G3020) EA Carapeti, MA Kamm, B Evans and RKS Phillips. Harrow, United Kingdom

P140PROGRAMOFTHEANNUALMEETING [I

AGA POSTER

GASTROENTEROLOGY VoL114~No.4 SESSION

-- TUESDAY,

M A Y 19, 1 9 9 8

Safety a n d efficacy of d i g i t a l r e c t a l e x a m i n a t i o n i n p a t i e n t s w i t h a c u t e m y o c a r d i a l i n f a r c t i o n . (Abstract# G0005) AJ Akhtar, D Moran, K Ganesan, J Akanno, T Tran, R Wu, M Alamy and VS Kaushik. Los Angeles, CA

Acceptance b y the AGA is t h e single best i n d i c a t o r of s u b s e q u e n t full p u b l i c a t i o n of research. (Abstract# G0185) A Timmer, JH Cole, C Macarthur, P Brasher, D Harley and LR Sutherland. Calgary, Canada

S o n o g r a p h i c p r e v a l e n c e of l i v e r lesions i n a n o n s e l e c t e d r u r a l p o p u l a t i o n . (Abstract# G0093) W Kratzer, A Callsen, RA Mason, K Beckh, P Kern, G Adler and the R6merstein Study Group. Ulm, Germany

ESOPHAGEAL, GASTRIC, AND DUODENAL DISORDERS - - HELICOBACTER PYLORI: PATHOGENESIS

The causes of the b i o c h e m i c a l p i c t u r e of hepatitis. (Abstract# G0198) MW Whitehead, ND Hawkes, I Hainsworth and JGC Kingham. Swansea, Wales

Lack of association b e t w e e n gastric p h e n o t y p i e expression of blood group a n t i g e n s with H. pylori infection a n d f u n d i c g l a n d polyps. (Abstract# G0373) C Ch0, RT Trappasso and K-J Carney. Stratford, CT

A n t i b i o t i c p r o p h y l a x i s for s p o n t a n e o u s b a c t e r i a l p e r i t o n i t i s i n cirrhosis - a s t r a t e g y of r i s k s t r a t i f i c a t i o n i m p r o v e s cost-effectiveness. (Abstract# G0033) A Das. Cleveland, OH

Hellcohacterpylord i n f e c t i o n a n d the m e t a b o l i c c o n t r o l

Grip s t r e n g t h - its role i n c h r o n i c liver disease. (Abstract# G0173) S Soo, S Hyder Hussaini, B Oldroyd, SP Stewart, M Smith and MS Losowsky. Leeds, United Kingdom P e r c u t a n e o u s liver b i o p s y - do gastroenterologist/hepatologists h a v e a different a p p r o a c h c o m p a r e d to radiologists? (Abstract# G0115) W Mayoral, P Roy, J Salced0 and JH Lewis. Washington, DC P e r c u t a n e o u s liver b i o p s y w i t h d e t e r m i n a t i o n of the s k i n to liver distance: a n o u t c o m e analysis. (Abstract# G0013) DE Bernstein, F Gress, J Rizzo, J Tripodi and R Burakoff. Mineola and Stony Brook, NY

of p a t i e n t s w i t h diabetes type I a n d II. (Abstract# G0286) RE Begue, A Mirza, T Compton and A Vargas. New Orleans, LA Changes i n c a l c i t o n i n g e n e - r e l a t e d p e p t i d e a n d substance P/tachykinin immunoreactivity in sensory nerves of r a t s c h r o n i c a l l y i n f e c t e d w i t h H. pylori. (Abstract# G0403) R DeGiorgio, G Barbara, P Blennerhassett, L Cogliandro, V StangheUini, H Li, H Larsson, R Corinaldesi and SM Collins. Bologna, Italy; Hamilton, Canada and Sweden Chronic effects of IIelicobacterpylori extracts o n r a t gastric m u c o s a l m i c r o c i r c u l a t i o n in vivo. (Abstract# G0675) N Kalia, KD Bardhan, MWR Reed, D Morton, S Jacob and NJ Brown. Sheffield and Rotherham, United Kingdom

High p r e v a l e n c e a n d profile of t u b e r c u l o s i s i n chronic l i v e r disease p a t i e n t s . (Abstract# G0156) S Saigal, HP Nandeesh, SR Agarwal, A Misra, SK Jain and SK Sarin. New Delhi, India

Different effects of eagA÷/vacA[sla/ml] tt. pylori o n r a t gastric m u c o s a l m i c r o c i r c u l a t i o n in vivo. (Abstract# G0676) N Kalia, KD Bardhan, MWR Reed, D Morton, JC Atherton, S Jacob and NJ Brown. Sheffield, Rotherham and Nottingham, United Kingdom

Use of novel World Wide Web t e c h n o l o g y to find a n d s t u d y p a t i e n t s w i t h c h o l a n g i o c a r c i n o m a . (Abstract# G0037) PC de Groen, JA Barry and WJ Schaller. Rochester, MN

I m p a c t of Helieobacterpylordinfection o n gastroesophageal reflux. (Abstract# G0820) A Leodolter, JE Dominguez-Mufioz, C Gerards, A Hackelsberger and P Malfetheiner. Magdeburg, Germany

I n c r e a s i n g use of t h e World Wide Web i n academic gastroenterology: a s t a t u s r e p o r t one year later. (Abstract# G0089) CY Kim. Charleston, SC

Helicobaeterpylori.induced gastritis m a y c o n t r i b u t e to

P r e v a l e n c e of u n e x p l a i n e d left h e a r t m a n i f e s t a t i o n s i n c a r c i n o i d h e a r t disease. (Abstract# G0060) RC Funck, S Freudenberg, A Misic, W Cassel, M Sassen, M Frank, M Wied, B Maisch and R Arnold. Marburg, Germany Gastrointestinal complications in heart transplant recipients. (Abstract# G0120) F Minniti, S Pevere, A Graziotte, P Burra, A Buda, M Chiaramonte, U Livi, R Naccarato and S Fagiuoli. Padua, Italy What the g a s t o e n t e r o l o g i s t does all day: a d e c a d e later. (Abstract# G0152) MW Russ0, BN Gaynes and DA Drossman. Chapel Hill, NC Is t h e r e bias i n t h e selection of a b s t r a c t s for p r e s e n t a t i o n at the DDW? (Abstract# G0186) A Timmer, C Macarthur, RJ Hilsden, P Brasher, JH Cole, D Harley and LR Sutherland. Calgary, Canada

the o c c u r r e n c e of p o s t p r a n d i a l s y m p t o m a t i c h~poglycemia. (Abstract# G0210) O A~bay, P Kadioglu, A Celik and S Giindogdu. Istanbul, Turkey Twenty-four h o u r esophageal p H - m e t r y i n p a t i e n t s with n o n - u l c e r dyspepsia is u n c h a n g e d after H. pylori eradication. (Abstract# G0342) F Carbone, M Neri, F Laterza, M Ricciuti, Z Sajterova and F Cuccurullo. Chieti, Italy Esophagitis post-Helieobaeterpylori e r a d i c a t i o n is associated w i t h p e r s i s t e n t l y low a n t r a l D-cell density. (Abstract# G0972) UK Murthy, N Narayana, WG Linscheer, J Nandi and A Oler. Syracuse, NY S i m u l t a n e o u s analysis of t h e vaeA, eagA a n d iceA status of ltelieobacterpyloriby m u l t i p l e x P C R a n d reverse h y b r i d i z a t i o n . (Abstract# G13U) LJ van Doom, C Figueiredo, R Sanna and W Quint. Delft, The Netherlands and Porto, Portugal Genetic o r g a n i z a t i o n a n d m o l e c u l a r t y p i n g of the Helieobacter pylori ieeA gene. (Abstract# G 1309) LJ van Doom, C Figueiredo, R Sanna and WGV Quint. Delft, The Netherlands

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A G A P O S T E R S E S S I O N - - T U E S D A Y , MAY 19, 1998 IceA1 is a n i n d e p e n d e n t Helivobavterpylori s t r a i n m a r k e r for p e p t i c u l c e r disease. (Abstract# G0499) D Figueiredo, W Quint, P Schneeberger, W de Boer and LJ van Doom. Den Bosch and Oss, The Netherlands P r e v a l e n c e of HeHcobacterpylori cagA gene a n d r e l a t i o n s h i p b e t w e e n cagA gene a n d the severity of gastritis i n K o r e a n p a t i e n t s . (Abstract# G0716) DY Kim and IH Moon. Seoul, Korea Is t h e r e a c o r r e l a t i o n b e t w e e n vacA genotype a n d peptic u l c e r diseases i n K o r e a n p a t i e n t s ? (Abstract# G1041) SM Park, JG Kim, JW Park, JH Cho and GK Yoo. Seoul, Korea Lack of a s s o c i a t i o n b e t w e e n vacA s u b t y p e s a n d disease i n Helicobacterpyloriinfected p a t i e n t s from the N e t h e r l a n d s . (Abstract# G1301) A van der Ende, Z-J Pan, RWM van der Hulst, P Roorda, M Feller, GNJ Tytgat and J Dankert. Amsterdam, The Netherlands Test of the h y p o t h e s i s t h a t vacA genotypes of Helicobacterpylori correlate with CagA status, cytotoxin p r o d u c t i o n , or clinical outcome. (Abstract# G1380) Y Yamaoka, T Kodama, M Kita, J Imanishi, K Kashima and DY Graham. Kyoto, Japan and Houston, TX A low m o l e c u l a r weight a n t i g e n (33/35K antigen) a n d its

r e l a t i o n to p e p t i c u l c e r disease i n J a p a n . (Abstract# G1377) Y Yamaoka, T Kodama, K Kashima and DY Graham. Kyoto, Japan and Houston, TX H o w good are the serological tests t h a t have b e e n used to m a k e / / , pylori disease associations with CagA or VacA? (Abstract# G1379) Y Yamaoka, T Kodama, K Kashima and DY Graham. Kyoto, Japan and Houston, TX

Helicobacterpyloriinduces gastric mucosal i n j u r y i n d e p e n d e n t l y of v a c u o l a t i n g cytotoxin. (Abstract# G1234) A Takagi, S Watanabe, M Igarashi, K Kohda, AMA Kabir, U Aiba, T Shirai, Y Koga and T Miwa. Kanagawa, Japan Risk for d e v e l o p i n g gastric c a r c i n o m a i n p a t i e n t s colonized b y cagA positive Hclicobactcrpylorl strains. (Abstract# G1082) DMM Queiroz, EN Mendes, GA Rocha, AMR Oliveira, CA Oliveira, PP Magalhaes, SB Moura, MMMDA Cabral and AMMF Nogueira. Belo Horizonte, Brazil P h e n o t y p i c a n d g e n e t i c d i v e r s i t y of u r e a s e from clinical isolated s t r a i n s of Helicobacterpylori. (Abstract# G1253) T Tanahashi, M Kita, K Sakai, N Sawai, Y Yamaoka, T Kodama, K Kashima and J Imanishi. Kyoto, Japan

cagA s u b t y p e disease associations v a r y i n different c o n t i n e n t s . (Abstract# G0545) MF Go, L Cissell, DY Graham, JG Kim and O Gutierrez. Houston, TX; Seoul, Korea and Bogota, Colombia C o r r e l a t i o n of H. pylori-related Cag A with severity of f u n d i c gastritis a n d gastric secretion. (Abstract# G1059) W Peterson, M Feldman, B Cryer, E Lee, G Perez and M Blaser. Dallas, TX and Nashville, TN S u l f o m u c i n s d e t e r m i n e a d h e s i o n of Helicobacterpylori to m e t a p l a s t i c gastric mucosa. (Abstract# G0323) JC Bravo and P Correa. New Orleans, LA

M e c h a n i s m of c o l o n i z a t i o n of H. pylori i n the s t o m a c h of M o n g o l i a n gerbils, a n a n i m a l model for c h r o n i c gastritis a n d ulcer: analysis of glycolipids a d h e s i o n receptors. (Abstract# G1026) H Osawa, M Kawakami, T Nakao, M Tada, K Sugano and M Iwamori. Omiya, Osaka and Tokyo, Japan

DDW Poster of Distinction: Competitive exclusion of H. pylori from the r o d e n t a n t r u m b y H. fells. I n s i g h t s i n t o gastric colonisation. (Abstract# G0825) V Leung, S Veldhuyzen van Zanten, J O'Rourke and A Lee. Hong Kong, PR China; Dalhousie, Canada and Sydney, Australia S i m u l t a n e o u s gastric c o l o n i z a t i o n b y m u l t i p l e s t r a i n s of Helieobacterpylor~. direct d e t e c t i o n from gastric biopsies a n d gastric a s p i r a t e s . (Abstract# G0268) PK Bardhan, P Bauerfeind, L Wolfram and M Fried. Ztirich, Switzerland

DDW Poster of Distinction: Lipid profiles of Helieobacterpylo~ p h a s e v a r i a n t s . (Abstract# G1256) T Tann~es, HJ Grav, I Guldvog and G Bukholm. Oslo, Norway Q u a n t i f y i n g the cellular d a m a g e p r o d u c e d b y H. pylori toxins. (Abstract# G0963) D Morton, C Potter and KD Bardhan. Rotherham and Sheffield, United Kingdom A t t e n u a t e d fluorescence i n Helicobacterpylori u p o n coccoid t r a n s f o r m a t i o n - shuffling off the m o r t a l D N A coil? (Abstract# G0961) D Morton, C Potter and KD Bardhan. Sheffield, United Kingdom Changes i n t h e e v o l u t i o n of t h e a n t i g e n i c profiles a n d u l t r a s t r u c t u r e d u r i n g coccoid c o n v e r s i o n of Hellcobacterpylori. (Abstract# G1106) IH Roe, YJ Jin, CY Chang, IH Song, JW Kim, JH Shin and JH Lee. Chun-an, Korea

DDW Poster of Distinction: Allelic v a r i a t i o n i n the cagA gene of Helicobacterpylori i n gastric c a n c e r a n d its role i n carcinogenesis. (Abstract# G2758) IH Roe, YJ Jin, CY Lira, IH Song, JW Kim, JH Shin and JH Lee. Chun-an, Korea Catalase a n d g l u t a t h i o n e p e r o x i d a s e a c t i v i t y i n AGS cells is a l t e r e d by exposure to cagA-negative a n d cagApositive H. pylori strains. (Abstract# Gl188) DT Smoot, D Jones, T Elliott, CR Allen and H Ashtorab. Washington, DC

Helicobactcrpyloriinfection to p o l a r i z e d CaCo-2 h u m a n colon cell monolayers. (Abstract# G0718) JG Kim, HC Jung, BC Yoo, IS Song, SM Park and CY Kim. Seoul, Korea DDW Poster of Distinction: S t r u c t u r e of c a g p a t h o g e n i c i t y i s l a n d i n J a p a n e s e a n d w e s t e r n Helicobacterpylori isolates. (Abstract# G0861) S Maeda, T Ikenoue, K Ogura, H Yoshida, F Kanai, N Kato, Y Shiratori and M Omata. Tokyo, Japan IL-8 r e s p o n s e b y J a p a n e s e Hclicobacterpylori s t r a i n s with different c a g p a t h o g e n i c i t y i s l a n d s t r u c t u r e s . (Abstract# G0860) S Maeda, T Ikenoue, K Ogura, H Yoshida, F Kanai, N Kato, Y Shiratori and M Omata. Tokyo, Japan

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I s o l a t i o n a n d e x p r e s s i o n of a n i s o c i t r a t e d e h y d r o g e n a s e g e n e f r o m Hcllcobacterpylori. (Abstract# G0635) LL Huang, DR Cave and A Wright. Boston, MA S i m p l e a n d p r a c t i c a l m e t h o d s to s t u d y cag p a t h o g e n i c i t y i s l a n d ; u s e a g e of cage a n d c a g T g e n e a m p l i f i c a t i o n . (Abstract# G0641) T Ikenoue, S Maeda, K Ogura, H Yoshida, F Kanai, Y Shiratori and M Omata. Tokyo, Japan G a s t r i t i s i n d u c e d b y Hclicobacter pylorlin M o n g o l i a n gerbils w i t h g a s t r i c ulcer. (Abstract# G1331) R Wada, T Arakawa, T Watanabe, N Hamasaki, Y Fujiwara, K Higuchi, T Fukuda, O Takalshi, K Yamasaki, K Kobayashi and T Kuroki. Osaka, Japan H e a t s h o c k p r o t e i n s as a s o u r c e of d i - m e t h y l a t e d a r g i n i n e i n Helicobacterpylori. (Abstract# G1060) A Pettersson, I B6hlin, C yon Bottmer, B Johansson, M Holm and L F~ndriks. G6teborg, Sweden

DDW Poster of Distinction: P e p s i n b i n d s to ttelicobactcrpylori a n d i n h i b i t s its g r o w t h i n v/tro. (Abstract# G0551) GS Goetz, T Hudson, DH Alpers and SN Abraham. Little Rock, AR; St Louis, MO and Durham, NC

E. coIi e x p r e s s i n g Heh'cobactcr pylori u r e a s e is s u s c e p t i b l e to acid. (Abstract# G0774) P Krishnamurthy, M Parlow, NB Vakil, HLT Mobley, M Levy, SH Phadnis and BE Dunn. Milwaukee, WI; Baltimore, MD and St Louis, MO P e n i c i l l i n b i n d i n g p r o t e i n 4 is d i f f e r e n t i a l l y r e g u l a t e d b e t w e e n e a r l y a n d l a t e log p h a s e H. pylor£ (Abstract# G0776) P Krishnamurthy, M Parlow, N Vakil, SH Phadnis and BE Dunn. Milwaukee, WI

tt. pylorl urease c a n b e e x c l u s i v e l y c y t o p l a s m i c in vivo. (Abstract# G0775) P Krishnamurthy, M Parlow, N Vakil, SH Phadnis and BE Dunn. Milwaukee, WI Protein kinase C inhibitors and antioxidants attenuate i n t e r l e u k i n - 8 p r o d u c t i o n f r o m g a s t r i c e p i t h e l i a l cells i n d u c e d b y Hch'cobactcrpylori w a t e r e x t r a c t . (Abstract# G0689) K Kassai, N Yoshida, Y Naito, Y Morita, T Yoshikawa and M Kondo. Kyoto, Japan

Helicobactcrpylori a t t e n u a t e s s u l f h y d r y l levels i n t h e g a s t r i c cell l i n e HM02. (Abstract# G0287) W Beil, S Wagner, B Obst, G Kirchner and K-F Sewing. Hannover, Germany Signal transduction pathways involving interleukin-8 p r o d u c t i o n i n g a s t r i c e p i t h e l i a l cells s t i m u l a t e d b y ttelicobacterpylori. (Abstract# G0818) YC Lee, HY Lee, WH Kim, JK Kang, YM Moon and IS Park. Seoul, Korea

Hellcobactcr pylorl l i p o p o l y s a c c h a r i d e - s t i m u l a t e d e n t e r o c h r o m a f f i n - l i k e cell m i t o g e n e s i s is m o d u l a t e d i n p a r t b y a n o v e l CD14 r e c e p t o r - m e d i a t e d p o l y a m i n e p a t h w a y . (Abstract# G0714) M Kidd, LH Tang, J L~iuffer, T Zhang and IM Modlin. New Haven, CT

Helicobactcrpylori a s s o c i a t e d a n t r a l i z a t i o n of p r o x i m a l g a s t r i c m u c o s a is l i n k e d to a n i n c r e a s e d r i s k of d e v e l o p m e n t of i n t e s t i n a l m e t a p l a s i a . ( A b s t r a c t # G1369) HH-X Xia, J Kalantar, JM Wyatt, S Adams, K Cheung and NJ Talley. Sydney, Australia

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Difference i n e x p r e s s i o n of H. pylorl a n d g a s t r i t i s i n a n t r u m a n d c o r p u s a n d t h e effect of e r a d i c a t i o n u p o n c h r o n i c g a s t r i t i s a n d i n t e s t i n a l m e t a p l a s i a . (Abstract# G0722) N Kim, J J Ko, SH Lim and KH Lee. Seoul, Korea Reversibility of intestinal metaplasia in the stomach a f t e r H. pylori e r a d i c a t i o n . (Abstract# G0901) N Matsukura, M Onda, S Kato, H Hasegawa, T ¥oshiyuki, T Shirakawa, M Takita, Y Akiya, K Ikeda, K Okawa, A Tokunaga, J Yamahatsu, M Wen and N Yamada. Tokyo, Japan Low i n c i d e n c e of H. pylorlinfection in p a t i e n t s w i t h d u o d e n a l u l c e r a n d c h r o n i c l i v e r disease. (Abstract# Gl163)

W Shahin, MZ Abdel-Baset, AK Nassar, MM Atta and SM Kabil. Iowa City, IA C h a r a c t e r i s t i c s of g a s t r i c u l c e r s t h a t r e c u r i n s p i t e of Helicobactcrpyloriinfection b e i n g cured. (Abstract# G0986) H Nebiki, T Arakawa, K Kioka, O Kurai, K Okawa, H Oka, S Harihara, K Ando, T Uchida, H Ito, K Higuchi, T Kuroki and K Kobayashi. Osaka, Japan

DDW Poster of Distinction: H i s t o p a t h o l o g i c a l differences b e t w e e n Itelicobacter pylori g a s t r i t i s of c h i l d r e n a n d a d u l t s . (Abstract# G1351) AE Whitney, J Guarner, L Hutwagner and BD Gold. Atlanta, GA C o r r e l a t e s of g a s t r i c b o d y i n f l a m m a t i o n b a s e d on h u m o r a l r e s p o n s e s to H. pyIorl a n d CagA a n t i g e n s . (Abstract# G1053) GI Perez-Perez, J Gaensbauer, N Bhat, KT Tham, RM Peek and MJ Blaser. Nashville, TN A n t r a l g a s t r i t i s a n d g a s t r i c MALT i n d u c e d b y e x p e r i m e n t a l Hellcobacterpyloriinfection i n g u i n e a pigs. (Abstract# Gl183) NH Shomer, CA Dangler, MT Whary and JG Fox. Cambridge, M A Clonal evolution in H. py]ori-associated chronic gastritis. (Abstract# G0846) N Liigering,M Kraft, T Kucharzik, W D0mschke, R Stoll, P Parwaresch and M Tiemann. Muenster and Kiel, Germany

Effects of a c h r o n i c HelicobactcrpyIori i n f e c t i o n on t h e g a s t r i c m u c u s gel in vivo. (Abstract# G0247) C Atuma, M Johansson, L Engstrand, H Li and L Holm. Stockholm and Gothenburg, Sweden Effect of v i t a m i n E on Hclicobactcrpylori-induced g a s t r i c m u c o s a l i n j u r y . (Abstract# G1214) N Sugimoto, N Yoshida, K Kassai, H Ichikawa and T Yoshikawa. Kyoto, Japan HLA DQBI*0401 is a s s o c i a t e d w i t h t h e d e v e l o p m e n t of a t r o p h i c g a s t r i t i s in H. pylorl-infected p a t i e n t s . (Abstract# GU25) T Sakai, N Aoyama, K Satonaka, S Shigeta, H Yoshida, K Shirakawa, T Iida, Y Shinoda, T Ikemura, M Sakashita, D Shirasaka, M Miyamoto and M Kasuga. Kobe, Japan CagA+ ttelicobacterpylorl s t r a i n d e l a y s g a s t r i c u l c e r h e a l i n g in m o u s e t h r o u g h i n d u c t i o n of a p o p t o s i s . (Abstract# G0764) PC Konturek, P Pierzchalski, T Brzezowski, EG Hahn and SJ Konturek. Erlangen-Nuremberg, Germany and Krakow, Poland

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I m p a c t of Helieobacterpylorlinfection on h e a t shock p r o t e i n r e s p o n s e i n gastric mucosa. (Abstract# G0766) PC Konturek, H Fischer, EG Hahn, W Domschke, J Neumann, W Schmitz and JW Konturek. ErlangenNuremberg and Muenster, Germany A u g m e n t a t i o n of w a t e r i m m e r s i o n stress-induced gastric m u c o s a l lesions i n BALB/c mice infected with Helieobaeter fells. (Abstract# G0904) Y Matsushima, Y Kinoshita, M Watanabe, S Hassan: H Fukui, T Maekawa, A Okada, C Kawanami, K Kishi, M Naka0 and T Chiba. Kobe, Osaka and Ky0to, Japan Effect of Helieobaeterpylorlinfection on NSAIDi n d u c e d g a s t r i c m u c o s a l i n j u r y . (Abstract# G1400) N Yoshida, N Sugimoto, Y Nakamura, H Ichikawa, Y Naito and T Yoshikawa. Kyoto, Japan D i s t r i b u t i o n of s m o o t h muscle cell b u n d l e s i n the gastric m u c o s a w i t h or w i t h o u t Helleobaeterpylorl i n f e c t i o n a n d t h e i r r e l a t i o n s h i p with mast cells. (Abstract# G0979) S Nakajima, T Hattori, B Krishnan, H Ota, DY Graham and RM Genta. Shiga, Japan and Houston, TX Significance of H. pylori CagA a n d VacA genotypes on apoptosis of gastric e p i t h e l i a l cells. (Abstract# G1333) S Wagner, D Wingbermfihle, W Befl, B Obst, I Sobek-Kl0cke, H Schmidt, J Bleck and MP Manns. Hannover, Germany

HeHeobacterpylori vacA s l a s t r a i n s a t t e n u a t e apopsosis i n vitro a n d in vivo t h r o u g h a toxini n d e p e n d e n t m e c h a n i s m . (Abstract# G1051) RM Peek, SF Moss, TL Cover, HP Wirth, KT Tham, JC Atherton, PR Holt and MJ Blaser. Nashville, TN and New York, NY Seropositivity to CagA, HspA, a n d IgA identifies HeHcobacterpylori s t r a i n s t h a t i n d u c e p r e m a l i g n a n t c h a n g e s i n the gastric c a r d i a b u t n o t i n the esophagus. (Abstract# G2727) RM Peek, MF Vaezi, JR G01dblum, GW Falk, JJ Vicari, GI Perez-Perez, TW Rice, P Sechopoulos, JE Richter and MJ Blaser. Nashville, TN and Cleveland, OH

H. pylori e x t r a c t i n h i b i t s apoptosis of h u m a n n e u t r o p h i l s . (Abstract# G0669) HC Jung, JS Kim, JM Kim, IS Song and CY Kim. Seoul, Korea

Hellcobaeterpylorlinfection, a g i n g a n d gastric cell p r o l i f e r a t i o n . (Abstract# G0256) L Baldini, F Bonvicini, S Pretolani, G Epifanio, N Figura and G Gasbarrini. Bologna, Siena and Rome, Italy E x p r e s s i o n of TGF-a, EGF a n d apoptosis i n t h e gastric m u c o s a of p a t i e n t s w i t h Helieobacterpyloriinfection. (Abstract# G0305) C Blandizzi, G Gherardi, C Marveggi0, F Costa, S Marchi, M Bellini, G Maltinti and M Del Tacca. Pisa and Sondrio, Italy

Helleobaeterpylorlinduces apoptosis i n h u m a n gastric KATO III cells. M e d i a t i o n b y stress-activated p r o t e i n k i n a s e ? (Abstract# G0436) MJ Domek, B Prins, NT Nguyen, D Liang, FA Wyle, A Tarnawski, R Pal and A Warner. Long Beach and Irvine, CA R e g u l a t i o n of t u m o r necrosis factor (TNF) activity by soluble TNF r e c e p t o r s i n p a t i e n t s with Helicobaeter pyloriinfection. (Abstract# Gl169) J Shibata, H Goto, T Arisawa, Y Niwa, T Watanahe, K Tachi, M Tsukamura, Y Hisanaga, K Kamiya, T Od0ri and T Hayakawa. Nagoya, Japan

R e l a t i o n s h i p b e t w e e n i n t e r l e u k i n - l [ b e t a } mRNA level i n gastric f u n d i c m u c o s a a n d g a s t r i c j u i c e pH i n p a t i e n t s infected w i t h Helicobaeterpylori. (Abstract# G0923) W Mengchun, T Furuta, M Takashima, H Futami, H Hanai and E Kaneko. Sheng yang, China and Hamamatsu, Japan Cloning a n d f u n c t i o n a l c h a r a c t e r i z a t i o n of a membrane-boundproinflammatory protein in Hellcobaeterpylori. (Abstract# G1397) M Yoshida, Y Kobayashi, T Itoh, K Murakami, A Mizoguchi, T Usui, T Chiba, T Kita and Y Wakatsuki. Kyoto and Osaka, Japan C-X-C c h e m o k i n e mRNA e x p r e s s i o n i n d u c e d by H.

pyloriinfection correlates w i t h b a c t e r i a l d e n s i t y i n gastric mucosa. (Abstract# Gl176) T Shimoyama, SR Everett, MF Dixon, ATR Ax0n, A Munakata and JE Crabtree. Leeds, United Kingdom and Hir0saki, Japan The gastric m u c o s a l i m m u n e r e s p o n s e of p a t i e n t s with H. pylori infection. (Abstract# G1135) S Saraff, C Neace, S Jackman and Y Elitsur. Huntington, WV Specific role of i n t e r l e u k i n - 1 2 a n d i n t e r l e u k i n - 1 0 i n the pathophysiology of HeIicobaeterpylori-induced gastritis. (Abstract# G0276) J Bauditz, M Ortner, M Bierbaum, M Niedobitek, H Lochs and S Schreiber. Berlin, Germany I n t e r l e u k i n - 8 p r o d u c t i o n i n p r i m a r y c u l t u r e s of h u m a n gastric e p i t h e l i a l cells i n d u c e d b y Helieobaeterpylor£ (Abstract# G1008) K Ogura, M Takahashi, S Maeda, T Iken0ue, F Kanai, H Y0shida, Y Shiratori, K Mori, K-i Mafune and M Omata. Tokyo, Japan I n t e r i e u k i n - 8 e x p r e s s i o n of h u m a n n e u t r o p h i l s activated b y H. pylori soluble p r o t e i n s . (Abstract# G0720) JS Kim, HC Jung, JM Kim, IS Song and CY Kim. Seoul, Korea Single exposure of w o u n d e d cell m o n o l a y e r to extracts of Hellcobaeterpyloribut n o t of c o c u l t u r e with living Helieobaeterpylorl decreases cell m i g r a t i o n via a r e d u c e d expression of TGF~I. (Abstract# G0473) H Ernst, S Winkler, A Foryst, K Vogt and H Lochs. Berlin, Germany Effects of H. pylori a n d i n t e r l e u k i n - 8 o n h i s t a m i n e release from isolated h u m a n g a s t r i c m u c o s a l m a s t cells. (Abstract# G0771) M Koyanagi, K Yakabi, T Arimura, Y Uehigashi, N Wada and T Nakamura. Chiba, Japan /L-lp gene allele 2 involves t h e d e c r e a s e d p r o d u c t i o n of gastric m u c o s a l IL-I~ i n r e s p o n s e to Helicobaeterpylori of c o m m o n genetic s t r a i n i n J a p a n a n d relates to the p a t h o g e n e s i s of d u o d e n a l ulcer. (Abstract# G0947) T Mochizuki, K Sugimura, Y Sato, K Ishizuka, T Honma, H Enomoto, J Matsuzawa, M Kobayashi, Y Baba, A Suriki, K Suzuki, R Narisawa and H Asakura. Niigata, Japan

DDW Poster of Distinction: H. pyloriproduces a soluble factor w h i c h i n h i b i t s ENA78 c h e m o k i n e p r o d u c t i o n b y AGS gastric epithelial cells. (Abstract# G0707) S Keates, A Fatimi, AC Keates, M Warny, P Michetti and CP Kelly. Boston, MA

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Effects of e r a d i c a t i o n of Helicobaeterpylori o n mueosal e x p r e s s i o n a n d i n t r a g a s t r i c r e l e a s e of p r o i n f l a m m a t o r y cytokines i n h u m a n s . (Abstract# G0760) JW Konturek, PC Konturek, E Karezewska, J Stachura, EG Hahn, SJ Konturek and W Domschke. Muenster, Germany and Cracow, Poland Decreased mRNA e x p r e s s i o n of E G F r e c e p t o r ligands i n Helicobaeterpylorl-infected gastric mucosa. (Abstract# G1145) U Schiemann, JW Konturek, M Osterhoff, R Assert, SJ Konturek, H Schatz, W Domschke and A Pfeiffer. Muenster and Bochum, Germany; Cracow, Poland I n h i b i t i o n b y r e b a m i p i d e of p r o i n f l a m m a t o r y cytokine p r o d u c t i o n b y h u m a n m o n o c y t e s s t i m u l a t e d with Helieobaeterpylori w i t h o u t p r o s t a g l a n d i n . (Abstract# G0514) T Fukuda, T Arakawa, T Watanabe, K Tominaga, O Takaishi, Y Fujiwara, K Higuchi, K Kobayashi and T Kuroki. Osaka, Japan The effect of e r a d i c a t i o n o n t h e levels of CXC c h e m o k i n e s a n d h e p a t o c y t e g r o w t h factor i n H. pyloriassociated g a s t r o d u o d e n a l disease. (Abstract# G0954) M Mori, H Suzuki, AA Sakaguchi, K Seto, T Kawagnchi, M Suzuki, S Miura and H Ishii. Tokyo, Japan Differential effects of cytokines o n m u c u s secretion by r a b b i t gastric e p i t h e l i a l cells i n the a b s e n c e a n d p r e s e n c e of Helicobaeterpylori c o m p o n e n t . (Abstract# G1239) S Takahashi, E Nakamura, N Suzuki and S Okabe. Kyoto, Japan Acid-activated v a c u o l a t i n g cytotoxins of Helieobacter pyloriinhibit b o t h the p r o s t a g l a n d i n - d e p e n d e n t a n d the g u a n y l i n - d e p e n d e n t b i c a r b o n a t e secretions i n isolated r a t d u o d e n a l m u c o s a in vitro. (Abstract# G1385) A Yanaka, H Suzuki, H Matsui, A Nakahara, S Takahashi, T Ito and H Muto. Ibaraki and Tokyo, Japan

DDW Poster of Distinction: Effect of H. pylori i n f e c t i o n o n H÷/K÷-ATPase mRNA e x p r e s s i o n i n gastric f u n d i c g l a n d m u c o s a i n p a t i e n t s w i t h c h r o n i c active gastritis a n d H. pylorlinfection. (Abstract# G0522) T Furuta, S Baba, M Takashima, H Hanai and E Kaneko. Hamamatsu, Japan Effect of H. pyloriinfection o n t h e expression of COX-2 i n gastric mucosa. (Abstract# Gl160) AA Shah, L CuUen, A O'Neill, A All, T Keane, DJ Fitzgerald and FE Murray. Dublin, Ireland

DDW Poster of Distinction: I n c r e a s e d e x p r e s s i o n of a n i n d u c i b l e isoform of n i t r i c oxide s y n t h a s e a n d t h e f o r m a t i o n of p e r o x y n i t r i t e i n gastric m u c o s a of H. pylorigastric ulcer. (Abstract# G0938) S Miura, AA Sakagnchi, T Takeuchi, R Hokari, M Mizumori, H Yoshida, H Higuchi, M Mori, H Kimura, H Suzuki and H Ishii. Tokyo, Japan Small m o l e c u l a r f r a c t i o n of d e g r a d e d Helicobaeter pylorlinhibits NO p r o d u c t i o n b y s t i m u l a t e d m u r i n e macrophages. (Abstract# G1330) C yon Bothmer, A Pettersson, I B61in, M Holm and L F~ndriks. G6teborg, Sweden

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DDW Poster of Distinction: P r e s e n c e of NO-synthase i n h i b i t o r ADMA i n H. pyloriinfected a n t r a l mucosa. (Abstract# G0486) L F~ndriks, C von Bothmer, H L6nroth, L Olbe and A Pettersson. G6teborg, Sweden

HelJcobacter pylori i n d u c e s m o r e cytotoxic inflammatory responses in the gastric mucosa in gastric u l c e r t h a n d u o d e n a l u l c e r via i n d u c i b l e n i t r i c oxide s y n t h a s e a n d p o l y m o r p h o n e u t r o p h i l i n f i l t r a t e . (Abstract# G0673) M Kaise, N Suzuki, J Miwa, K Iihara, M Hijikata, Y Ohta and K Kanai. Tokyo, Japan DNA analysis of H. pylorivirulence factors a n d s e m i q u a n t i t a t i v e mRNA m e a s u r e m e n t of p r o i n f l a m m a t o r y cytokines a n d iNOS i n the H.p.infected, c h r o n i c a l l y i n f l a m e d h u m a n gastric mucosa. (Abstract# G1077) C Prinz, R Lang, N Neumayer, M Sch6niger, M Classen, W Schepp, K Heeg, H Wagner, G H6fler and M Gerhard. Munich, Germany I n d u c i b l e n i t r i c oxide s y n t h e t a s e i n g a s t r o d u o d e n a l disease infected with CagA b e a r i n g Helicobacterpylori infection i n Korea. (Abstract# Gl194) HJ Son, J Kirn, PL Rhee, KC Koh, SW Paik, JC Rhee and KW Choi. Seoul, Korea

Hellcobaeterpylori-induced g a s t r i c m u c o s a l cell i n j u r y is m e d i a t e d b y i n d u c i b l e n i t r i c oxide syntase. (Abstract# G1340) S Watanabe, A Takagi, K Kohda, R Deguchi, JO Koike, T Shirai, Y Koga and T Miwa. Kanagawa, Japan Duodenal m u c o s a l i n j u r y by l u m i n a l a d m i n i s t r a t i o n of Hellcobacterpylori-related cytotoxic factor i n the rat, a n d its detoxification by sucralfate. (Abstract# G1339) K Watanabe, T Joh, K Seno, K Tsuchida, N Takahashi, Y Yokoyama, K Tochikubo and M Itoh. Nagoya, Japan Effects of p r o s t a g l a n d i n o n p r o d u c t i o n of p r o i n f l a m m a t o r y cytokines b y h u m a n m o n o c y t e s w h e n s t i m u l a t e d b y Helivobacterpylori. (Abstract# G1244) 0 Takaishi, Y Fujiwara, T Fukuda, K Otani, K Tominaga, T Watanabe, K Higuchi, K Yamasaki, T Arakawa, K Kobayashi and T Kuroki. Osaka, Japan The effect of Helleobaeterpyloriinfection o n gastric acid secretion a n d s e r u m g a s t r i n levels i n M o n g o l i a n gerbils. (Abstract# G1245) M Takashima, T Furuta, H Futami, H Hanai and E Kanek0. Hamamatsu, Japan 24-hour gastric pH a n d d u o d e n a l gastric m e t a p l a s i a one year after e r a d i c a t i o n of ttelieobaeterpylori infection i n d u o d e n a l u l c e r p a t i e n t s . (Abstract# Gl141) V Savarino, GS Mela, P Zentilin, MR Male, G Bisso, M Fivari, C Mansi, G Lapertosa, P Ceppa, S Vigneri and G Celle. Genoa and Palermo, Italy E r a d i c a t i o n of Itelieobaeterpylori increases g a s t r i c acidity i n p a t i e n t s with a t r o p h i c gastritis of c o r p u s e v a l u a t i o n of 24-hour pH m o n i t o r i n g . (Abstract# G0587) K Haruma, M Mihara, E Okamoto, H Kusunoki, M Hananoki, H Hamada, S Tanaka, M Yoshihara, K Sumii and G Kajiyama. Hiroshima, Japan Severity of a n t r u m gastritis p r e d i c t s the r e s p o n s e to GRP s t i m u l a t i o n of g a s t r i n a n d acid s e c r e t i o n i n H.p.associated gastritis a n d DU p a t i e n t s . (Abstract# G0312) JB BSjko, R Nustede, M Stolte, UR F61sch and WE Schmidt. Goettingen and Bayreuth, Germany

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DDW Poster of Distinction: Hellcobactcrpj,lori, a c t i n g via n e u r a l pathways, stimulates somatostatin and thus inhibits histamine a n d acid s e c r e t i o n i n the f u n d u s of r a t stomach. (Abstract# G1404) M Zaki, PE Ceudron, R McCuen, L Harrington and ML Schubert. Richmond, VA I n f l u e n c e of a m m o n i a a n d H. pylori lipopolysaccharide o n gastric s e c r e t i o n i n conscious dogs a n d rats. (Abstract# G0301) J Bilski, T Brzoz0wski, D Drozd0wicz, R Paid0, M Cieszkowski, W Bielanski and SJ Konturek. Cracow, Poland

H. pylori e r a d i c a t i o n r e d u c e s the effect of lansoprazole b u t n o t t h a t of r a n i t i d i n e o n i n t r a g a s t r i c pH. (Abstract# G1312) MA van Herwaarden, M Samsom, CHM van Nispen and AJPM Smout. Utrecht, The Netherlands P a r i e t a l cell a c t i v i t y is n o t r e l a t e d to a n t r a l D cells n u m b e r i n p a t i e n t s with d u o d e n a l ulcer. (Abstract# G1298) M Valenzuela, JL Martin, A LSpez-Andrade, A Caballero and F Nogales. Granada, Spain Effects of i n f l a m m a t o r y cytokines i n d u c e d b y Helicobacterpylori i n f e c t i o n o n a m i n o p y r i n e a c c u m u l a t i o n i n isolated p a r i e t a l cells of g u i n e a pig. (Abstract# G1255) N Tani, Y Watanabe, T Suzuki, S Muramatsu, M Miyazawa, N Kimura and T Miwa. Isehara, Japan Acid s e c r e t i o n was n o t r e d u c e d b y H. pylori e r a d i c a t i o n i n h y p e r s e c r e t o r y d u o d e n a l u l c e r a n d a n t r a l G cell h y p e r p l a s i a p a t i e n t s . (Abstract# G0231) B Annibale, G D'Ambra, M Marignani, G Ferraro, MR Aprile, G Martino, S Angeletti, C Bordi, VD Corleto, R Caprilli and G Delle Fave. Rome and Parma, Italy Na-methylhistamine, a Helicobacterpylori metabolite, is more p o t e n t H2 r e c e p t o r a g o n i s t t h a n h i s t a m i n e . (Abstract# G1251) M Tamai, T Saitoh, J Hirakawa, K Chishima, H M0ri, Y Fukushima, K Sugan0 and S Ohkawa. Tokyo, Japan Depth of Hclicobactcrpyloriin the oxyntic m u c o s a i n patients treated with proton pump inhibitors. (Abstract# G0534) RM Genta and DY Graham. Houston, TX

DDW Poster of Distinction: Effect of Hclicobacterpylorl acid i n h i b i t o r y factor-1 on t h e m o r p h o l o g y of p a r i e t a l cells i n isolated r a b b i t gastric glands. (Abstract# G0550) PJ Goddard, N Masubuchi, AV Kane, S Ito, GS Smith and DR Cave. Boston, MA and St Louis, MO Changes i n Helicobacterpylori-induced gastritis i n the a n t r u m a n d corpus u n d e r 12 m o n t h s of t r e a t m e n t with ranitidine and lansoprazole in patients with duodenal u l c e r disease. (Abstract# G0917) A Meining, G Kiel and M Stolte. Bayreuth and Aachen, Germany Does omeprazole t r e a t m e n t p r o m o t e the h y p e r p r o l i f e r a t i v e effects of a m m o n i a i n r o d e n t models of H e l i c o b a c t e r infection? (Abstract# G1328) X Villa, E Williams, EJ Dial, JJ Romero and LM Lichtenberger. Houston, TX

Hclicobacterpylori does n o t i m p a i r r e c e p t o r - m e d i a t e d h u m a n d u o d e n a l m u c o s a l a n i o n t r a n s p o r t i~ vitro. (Abstract# G1072) V Pratha, DL Hogan, SM Thompson, P Paulus, M Repishti and JI Isenberg. San Diego, CA

DDW Poster of Distinction: I n Helicobacter pylori-infected DU p a t i e n t s , i m p a i r e d p r o x i m a l d u o d e n a l b i c a r b o n a t e s e c r e t i o n is i n d e p e n d e n t of cyclic AMP a n d c e l l u l a r acid/base t r a n s p o r t e r s . (Abstract# G1073) V Pratha, DL Hogan, B Martensson, P Paulus and JI Isenberg. San Diego, CA The sialic acid b i n d i n g l e c t i n of Maackia amurensis s t i m u l a t e s g a s t r i n release from r a b b i t G cells: i m p l i c a t i o n s for Helicobacter pylori adhesins. (Abstract# G0309) PW Bliss, ZV Healey, N Arebi, M Jordinson and J Calam. London, United Kingdom G a s t r i n release m e d i a t e d b y H 2 receptors. (Abstract# G0307) PW Bliss, ZV Healey, N Arebi and J Calam. London, United Kingdom

DDW Poster of Distinction: The sialic acid b i n d i n g l e c t i n from Maackia amurcnsis i n h i b i t s z4C-aminopyrine a c c u m u l a t i o n by r a b b i t p a r i e t a l cells: i m p l i c a t i o n s for Hellcobacterpylori adhesins. (Abstract# G0603) ZV Healey, PW Bliss, N Arebi and J Calam. London, United Kingdom I N T E S T I N A L DISORDERS - - ENTEROCYTE MOLECULAR BIOLOGY

DDW Poster of Distinction: P r o t e i n k i n a s e C-mediated p h o s p h o r y l a t i o n of m y o s i n light c h a i n k i n a s e i n h i b i t s m y o s i n light c h a i n phosphorylation and results in increased t r a n s e p i t h e l i a l resistance. (Abstract# G1421) JM Angle, JL Joyal, ED Black, H Alli, DB Sacks, JL Madara and JR Turner. Detroit, MI; Boston, MA and Atlanta, GA

DDW Poster of Distinction: S t r u c t u r e - f u n c t i o n studies of m e m b r a n e d o m a i n cytoplasmic d o m a i n a n d m e m b r a n e d o m a i n - m e m b r a n e d o m a i n c h i m e r a s of Na÷/H÷ e x c h a n g e r isoforms NHE1 a n d NHE3. (Abstract# G1457) M Caret, CM Tse, S Akhter, C Yun and M D0n0witz. Baltimore, MD

DDW Poster of Distinction: The MUC2 gene 5'-flanking s e q u e n c e directs goblet cellspecific e x p r e s s i o n i n the s m a l l i n t e s t i n e of t r a n s g e n i c mice. (Abstract# G1532) JR Gum, Jr, JW Hicks, S Karnik, JC Hong and YS Kim. San Francisco, CA

DDW Poster of Distinction: MUC2 is the p r e d o m i n a n t secretory m u c i n i n the mouse colon. (Abstract# G1739) BJW Van Klinken, LA Duits, M Verburg, MK Makkink, KMAJ Tytgat, IB Renes, HA Biiller, AWC Einerhand and J Dekker. Amsterdam and Rotterdam, The Netherlands

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Hepatocyte n u c l e a r factor 3/fork h e a d homolog 11 is e x p r e s s e d d u r i n g h u m a n i n t e s t i n a l d e v e l o p m e n t a n d is overexpressed i n colonic a n d h e p a t i c t u m o r s . (Abstract# G1595) RM Lee, H Ye, RH Costa, D Baun0ch and NO Davidson. Chicago, IL I n v/tro glycoconjugate s e c r e t i o n b y i n t e s t i n a l tissue is u p r e g u l a t e d i n CFTR (-/-) mice. (Abstract# G1433) KR Bhaskar, SD Freedman, BS Turner and JT LaMont. Boston, MA P o l y a m i n e s n e g a t i v e l y r e g u l a t e p o s t t r a n s c r i p t i o n of the p53 gene i n s m a l l i n t e s t i n a l c r y p t cells. (Abstract# G1755) J-Y Wang, J Li, AR Patel, L Li and JN Rao. Baltimore, MD Association of t i g h t j u n c t i o n p r o t e i n s with a d i s t i n c t m e m b r a n e c o m p a r t m e n t . (Abstract# G1643) A Nusrat, CA Park0s, G Strohmeier, CS Foley, T Liang and JL Madara. Atlanta, GA Prolonged versus transient histone hyperacetylation: differential effects o n e n t e r o c y t e growth a n d differentiation. (Abstract# G1424) S Archer, J Johnson, S Meng, P Grable, JB Matthews and RA Hodin. Boston, MA Molecular c l o n i n g a n d t r a n s i e n t expression of r a b b i t N a - d e p e n d e n t n u c l e o s i d e t r a n s p o r t e r s . (Abstract# G1731) CM Tse, S Akhter, ZP Mo, M Cavet and J Ward. Baltimore, MD P o t e n t i a t i o n of c y t o k i n e - i n d u c e d n i t r i c oxide s y n t h a s e activity b y cyclic AMP d e r i v a t i v e s i n DLD-1 h u m a n i n t e s t i n a l e p i t h e l i a l ceils. (Abstract# G1458) M Cavicchi and BJR Whittle. London, United Kingdom Z o n u l a occludens t o x i n r e p r e s e n t s a n e w m e m b e r of the m i c r o t u b u l e - a s s o c i a t e d p r o t e i n s family. (Abstract# G1756) W Wang, R Lu, Y Pang and A Fasano. Baltimore, MD L o a d i n g of m e c h a n i c a l p r e s s u r e activates early i m m e d i a t e gene a n d c y t o k i n e s y n t h e s i s i n i n t e s t i n a l epithelial cells. (Abstract# G1582) H Kishikawa, S Miura, H Y0shida, M Hir0kawa, H Higuchi, S Zeki, M Adachi, RC Nakatsumi, H Suzuki, H Saito and H Ishii. Tokyo, Japan Tissue specific e x p r e s s i o n of b a s o l a t e r a l a n i o n exchange-2 isoform i n r a t colon. (Abstract# G1663) VM Rajendran, P Sangan, AS Mann, M Kashgarian, SL Alper, J Black and HJ Binder. Boston, MA and New Haven, CT Synergistic effect of r e t i n o i c acid a n d IL-I~ o n expression of t h e b o n e - t y p e a l k a l i n e p h o s p h a t a s e a n d r e t i n o i d r e c e p t o r s i n s m a l l i n t e s t i n a l epithelial cells. (Abstract# G1641) T Nikawa, K R0kutan, K Nanba, M Ikemot0, S Teshima, DH Alpers and K Kishi. Tokushima, Japan and St Louis, MO AE2a a n d AE2b e x p r e s s i o n s have d i s t i n c t tissue-related a n d d e v e l o p m e n t a l r e g u l a t i o n s . (Abstract# G1466) A Chow, R Zhang and T Peng. Atlanta, GA AE2a t r a n s c r i p t i o n is s t i m u l a t e d b y p h o r b o l ester. (Abstract# G1467) A Chow, R Zhang and T Peng. Atlanta, GA

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L . a r g i n i n e s t i m u l a t e s i n t e s t i n a l call m i g r a t i o n t h r o u g h a n i t r i c oxide- a n d p o l y a m i n e - d e p e n d e n t m e c h a n i s m . (Abstract# G1665) M Rhoads, R Argenzio, W Chen, F Sheth and L Romer. Chapel Hill and Raleigh, NC I d e n t i f i c a t i o n of the n u c l e o s i d e t r a n s p o r t e r s i n h u m a n small i n t e s t i n e a n d colonic epithelial cell lines. (Abstract# G1757) JL Ward and CM Tse. Baltimore, MD Stress i n d u c e s loss of e p i t h e l i a l t i g h t j u n c t i o n p e r m s e l e c t i v i t y i n t h e r a t i n t e s t i n e . (Abstract# G1508) W Fries, E Mazz0n and G Long0. Messina, Italy TNF-a activates ERK, JNK a n d p38 MAP-kinases i n IEC6 cells. (Abstract# G1483) S Dionne, FM Ruemmele, D Levesque and EG Seidman. Montreal, Canada A m e r i c a n a n d I r i s h w h e a t gliadins h a v e s i m i l a r a n t i g e n i c a n d tissue t r a n s g l u t a m i n a s e s u b s t r a t e specificities. (Abstract# G1571) AP Keaveny, GD Offner, E Bootie and DP Nunes. Boston, MA P o l y a m i n e levels i n colonic epithelial cells d u r i n g i n f l a m m a t o r y bowel disease. (Abstract# G1761) T Weiss, M Cetto, H Zirngibl, J Sch01merich, KW Jauch and G Rogler. Regensburg, Germany Localization of p r o s t a n o i d G-protein c o u p l e d r e c e p t o r s i n h u m a n colonic mucosa. (Abstract# G1766) K W0rledge, V Takafuji, D Lublin, K Lynch and JK Roche. Charlottesville, VA I n t e r a c t i o n s of t r a n s c r i p t i o n factors w i t h the p r o m o t e r of h u m a n calbindin-D9k. (Abstract# G1429) N Barley, A Howard, S Legon and JRF Walters. London, United Kingdom INTESTINAL DISORDERS - - E P I T H E L I A L PATHOBIOLOGY AND MUCOSAL I N F L A M M A T I O N

DDW Poster of Distinction: F u n c t i o n a l m a p p i n g of CDllb/CD18 epitopes i m p o r t a n t i n n e u t r o p h i l - e p i t h e l i a l i n t e r a c t i o n s : a c e n t r a l role of the I-domain. (Abstract# G1427) LB Balsam, TW Liang and CA Parkos. Boston, MA and Atlanta, GA Role of p r o t e i n k i n a s e C i n interferon-y d o w n r e g u l a t i o n of i o n t r a n s p o r t i n c u l t u r e d m u r i n e s m a l l i n t e s t i n e . (Abstract# G1599) W Lo, D Yoo, CE Semrad and M Field. New York, NY C r y p t cell apoptosis a n d i n c r e a s e d m u c o s a l p e r m e a b i l i t y i n d u c e d b y activated T cells. (Abstract# G1419) Z Alnadjim, R Koehler, Z Kayali, P Efthimiou, S Hurst, S Mandrea, E Chang, D Green, T Lin and TA Barrett. Chicago, IL and San Diego, CA C y t o k i n e - i n d u c e d e x p r e s s i o n of s u b s t a n c e P (NK-1) receptors i n h u m a n colonic e p i t h e l i a l cells. (Abstract# G1523) T Go0de, J O'Connell, GC O'Sullivan, JK Collins and F Shanahan. Cork, Ireland I d e n t i f i c a t i o n a n d cytokine r e g u l a t i o n of gap j u n c t i o n p r o t e i n s i n m a c r o p h a g e s a n d i n t e s t i n a l e p i t h e l i a l cell lines. (Abstract# G1614) CA Martin, S Sharma, M DeGaetano and R Burakoff. Mineola and Stony Brook, NY

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The i n h i b i t i o n of the OX40-OX40L i n t e r a c t i o n i n the r o u t i n e a c u t e graft-versus-host disease leads to a n o r m a l i z a t i o n of t h e i n t e s t i n a l morphology. (Abstract# G1710) E Sttiber, A yon Freier and UR F61sch. Kiel, Germany

N e u t r a l i z a t i o n of v a s c u l a r e n d o t h e l i a l growth factor prolongs i n t e s t i n a l i n f l a m m a t i o n i n h a p t e n - i n d u c e d colitis. (Abstract# G1627) K Mitsuyama, T Nishiyama, H Tateishi, T Saiki, M Ide, A Shirachi, N Tomiyasu, A Toyonaga, K Matsuo and K Tanikawa. Kurume and Ibaraki, Japan

D i a r r h e a a n d r e c t a l p r o l a p s e i n d u c e d by a n t i g e n specific T cell a c t i v a t i o n : a n e w model for s t u d y i n g m e c h a n i s m s i n i n f l a m m a t o r y d i a r r h e a . (Abstract# G1488) P Efthimiou, Z Alnadjim and TA Barrett. Chicago, IL

E n h a n c e d expression of MCP-3 i n c h r o n i c i n f l a m m a t o r y bowel disease. (Abstract# G1759) J Wedemeyer, A Lorentz, M G6ke, P Flemming, MP Manns and SC Bisch0ff. Hann0ver, Germany

DDW Poster of Distinction: M a g n e s i u m (Mg2÷) deficiency i n d u c e s i n f l a m m a t i o n a n d a l t e r e d e p i t h e l i a l f u n c t i o n i n r a t small i n t e s t i n e . (Abstract# G1622) E Mendez, A Dieringer, S Tao, M Haigney, V PifieiroCarrer0 and T Shea-Don0hue. Bethesda, MD

DDW Poster of Distinction: R e s i s t a n c e of C r o h n ' s disease m u c o s a l T cells to cell d e a t h is i n d e p e n d e n t of trigger: decreased anti-Fas a n d n i t r i c o x i d e - i n d u c e d apoptosis. (Abstract# G1553) J Itoh, S Kugathasan, T McCormick, EG Lapetina, AD Levine and C Fiocchi. Cleveland, OH

DDW Poster of Distinction: Acute a n d c h r o n i c effects of o x i d a n t exposure o n i n t e s t i n a l e p i t h e l i a l cell t r a n s p o r t a n d b a r r i e r function. (Abstract# G1713) K Sugi, MW Musch and EB Chang. Chicago, IL Actions of b r a d y k i n i n o n electrical a n d s y n a p t i c b e h a v i o r i n t h e m y e n t e r i c a n d s u b m u c o n s plexuses of g u i n e a p i g s m a l l i n t e s t i n e . (Abstract# G1547) H-Z Hu, S-M Liu, Y Xia, R Mostafa, DH Zafir0v and JD Wood. Columbus, OH Mast c e l l - d e p e n d e n t TNF-a mRNA expression is associated w i t h e a r l y n e u t r o p h i l r e c r u i t m e n t i n C5Ai n d u c e d g a s t r i c i n f l a m m a t i o n i n mice. (Abstract# G15U) RI Furlano and BK Wershil. Boston, MA P h o s p h o d i e s t e r a s e i n h i b i t o r s p r e v e n t NSAID-induced small i n t e s t i n a l i n j u r y : lack of a role for t u m o r necrosis factor-a. (Abstract# G1664) BK Reuter and JL Wallace. Calgary, Canada The role of c a l c i t o n i n gene-related p e p t i d e i n colonic i n f l a m m a t i o n a n d s e c r e t i o n i n the rat. (Abstract# G1497) T Esfandyari, WK MacNaughton, R Quiri0n, S St Pierre and KA Sharkey. Calgary and Montreal, Canada L i p o p o l y s a c c h a r i d e is r a d i o p r o t e c t i v e i n t h e mouse small i n t e s t i n e . (Abstract# G1667) TE Riehl, SR Schl0emann, TG Tessner and WF Stenson. St Louis, MO I n d u c t i o n of h u m a n colonic i n t e s t i n a l epithelial cell d e a t h b y interferon-T. (Abstract# G1732) N Tsuji, D Frederick and H Takahashi. Boston, MA

E n d o t h e l i a l changes p r e c e d e e p i t h e l i a l d i s r u p t i o n i n early NSAID damage: a n u l t r a s t r u c t u r a l s t u d y i n r a t j e j u n a l villi. (Abstract# G1574) D Kelly, C Piasecki, A Anthony, J Lewin, AP Dhillon, RE Pounder and AJ Wakefield. London, United Kingdom HSP27 i n d u c t i o n after h e a t shock a n d free r a d i c a l exposure i n IEC-6 cells. (Abstract# G1668) J Ries, K Sttirke, WF Caspary and J Stein. Frankfurt, Germany H u m a n fecal dialysate bioactivity: i n a c t i v a t i o n b y CaCo-2 epithelial m o n o l a y e r s a n d b y cyclosporin H. (Abstract# G1518) NM Garlick, RA Robins, A Galvin, CJ Hawkey and AT Cole. Nottingham, United Kingdom The t u m o r p r o m o t e r deoxycholic acid i n d u c e s apoptosis while the c h e m o p r e v e n t i v e a g e n t ursodeoxycholic acid i n h i b i t s cell proliferation. (Abstract# G1615) JD Martinez, ED Stratagoules, CM Payne, AK Batta, MT Craven, M Reid, DS Alberts, AA Powell, MB Powell and D Earnest. Tucson, AZ and Newark, NJ Calcium s t i m u l a t e d e n t e r o c y t e p r o s t a n o i d release is m e d i a t e d b y a cyclooxygenase-2 m e c h a n i s m . (Abstract# G1600) W Longo, Y Deshpande, C Reichenberg, G Smith, J Mazuski and D Kaminski. St Louis, MO P r o t e i n k i n a s e C m e d i a t e s e x p e r i m e n t a l colitis i n the rat. (Abstract# G1449) JF Brown, C Qing and BL Tepperman. London, Canada Role of r a t m a s t cell protease-2 i n i n t e s t i n a l t r a n s p o r t a n d b a r r i e r function. (Abstract# G1749) N Vergnolle, B Renaux, MD Hollenberg, AD Befus, WK MacNaughton and JL Wallace. Calgary and Alberta, Canada A n n e x i n 1: a n e w m a r k e r of s e v e r i t y i n u l c e r a t i v e colitis? (Abstract# G1748) N Vergnolle, P Pages, D Louvel, J Escourron, L Budno and C Comdra. Toulouse, France The levels a n d the s t r u c t u r e of fecal a l - a n t i t r y p s i n i n p a t i e n t s w i t h i n f l a m m a t o r y bowel disease. (Abstract# G1584) K Kojima, O Saitoh, K Sugi, S Tanaka, R Matsuse, K Tabata, K Uchida, K Nakagawa, T Teranishi, M Kayazawa, K Maemura, I Hirata and K Katsu. Osaka and Kyoto, Japan

E n d o t h e l i a l cell a d h e s i o n molecule expression i n i n t e r l e u k i n - 1 0 - d e f i c i e n t mice. (Abstract# G1630) Z Morise, E Conner, M Eppihimer, DN Granger, DC Anderson and MB Grisham. Shreveport, LA and Kalamazoo, MI

IL-8 s e c r e t i o n b y enterocytes i n r e s p o n s e to TNF-~ r e q u i r e s MAPK a n d is i n d e p e n d e n t of PKC. (Abstract# G1559) HB Jij6n and HG Parsons. Calgary, Canada

E v i d e n c e for n o v e l m e c h a n i s m s t h a t silence IL-8 gene t r a n s c r i p t i o n . (Abstract# G1762) XM Wen and GD Wu. Philadelphia, PA

L u m i n a l l i p o p o l y s a c c h a r i d e s t i m u l a t e s the i n t e s t i n a l m u c i n release via LPS-responsive m a c r o p h a g e s . (Abstract# G1494) M-L Enss, U Urlaub, R Eisenbl~itter, S Wagner, W Bell and HJ Hedrich. Hannover, Germany

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H y d r o l y z e d c a r r a g e e n a n i n j u r y of IEC-18 i n t e s t i n a l e p i t h e l i a l cells is m e d i a t e d b y oxygen free radicals. (Abstract# G1604) DT Luu and TY Ma. Long Beach and Irvine, CA M e c h a n i s m s of e n d o t h e l i n - l - i n d u c e d m u c o s a l d y s f u n c t i o n i n t h e r a t small i n t e s t i n e : role of leukocytes. (Abstract# G1565) B Karakoyun, T Coskun, A Bozkurt, B~ Yegen, M Yiiksel, G Haklar, DN Granger and H Kurtel. Istanbul, Turkey and Shreveport, LA Effects of w-3 f a t t y acids o n PAF s y n t h e s i s i n t r i n i t r o b e n z e n e sulfonic a c i d - i n d u c e d colitis i n rats. (Abstract# G1524) . A Gousseinov, AO Ozfitemiz, I Coker, H Yficeyar, M Alkanat and Y Batur. Izmir, Turkey G l u t a m i n e p r e v e n t s L P S - i n d u c e d NF-KB a c t i v a t i o n in h u m a n i n t e s t i n a l e p i t h e l i a l cells. (Abstract# S0164) MR Moon, TA Pritts, AL Salzman, JE Fischer and PO Hasselgren. Cincinnati, OH PANCREATIC DISORDERS - - PANCREATITIS: CLINICAL S T U D I E S

DDW Poster of Distinction: D e t e r m i n a n t s of o r g a n f a i l u r e i n p a t i e n t s with n e c r o t i z i n g p a n c r e a t i t i s . (Abstract# G1913) R Isenmann, B Rau, MH Schoenberg and HG Beget. Ulm, Germany Site of necrosis p r e d i c t s outcome i n p a t i e n t s with acute p a n c r e a t i t i s . (Abstract# G2003) JJ Powell, GWJ Hill, S-M Yong, D Redhead and AK Siriwardena. Edinburgh, Scotland P r o g n o s t i c v a l u e of e a r l y i n t r a v e n o u s c o n t r a s t enhanced computed tomography in acute pancreatitis. (Abstract# G2002) JJ Powell, GWJ Hill, S-M Yong, D Redhead and AK Siriwardena. Edinburgh, Scotland Day of a d m i s s i o n p r e d i c t o r s of m o r b i d i t y , m o r t a l i t y a n d l e n g t h of stay i n a c u t e p a n c r e a t i t i s . (Abstract# G1952) R Ligresti, PD Stevens, J Finegold, J Chabot, L Osborne and CJ Lightdale. New York, NY E a r l y r e c o g n i t i o n of p o s t - E R P - p a n c r e a t i t i s b y Serum a m y l a s e a n d its velocity of increase. (Abstract# G1966) H Messmann, W Vogt, A v F(irstenberg, S Griine, A Holstege and J Sch61merich. Regensburg, Germany E v a l u a t i o n of R a n s o n ' s a n d Glasgow scores i n p e d i a t r i c a c u t e p a n c r e a t i t i s . (Abstract# G1834) JR DeBanto, PS Goday, C Ulrich, Y A1-Tawil and LK Gates. Lexington, KY and Cincinnati, OH P r o g n o s t i c v a l u e of e n d o s c o p i c u l t r a s o u n d in acute p a n c r e a t i t i s . (Abstract# G2019) M Schoefer, A Rathgeber, J Lang, W Nagell and H Dancygier. Offenbach/Main, Germany Which is the critical B a l t h a z a r score v a l u e for i n d i c a t i n g o r g a n f a i l u r e i n acute p a n c r e a t i t i s ? (Abstract# G1941) PG Lankisch, D Pflichthofer, C Assmus and D Lehnick. Lueneburg and Goettingen, Germany Which etiology causes the most severe a c u t e p a n c r e a t i t i s ? (Abstract# G1940) PG Lankisch, C Assmus, D Pflichthofer, K Struckmann and D Lehnick. Lueneburg and Goettingen, Germany

Bactericidal/permeability-increasing p r o t e i n and group I a n d II p h o s p h o l i p a s e A 2 d u r i n g the i n d u c t i o n p h a s e of h u m a n acute p a n c r e a t i t i s . (Abstract# G1926) E Kemppainen, A Hietaranta, P Puolakkainen, V Sainio, J Halttunen, R Haapiainen, E Kivilaakso and T Nevalainen. Helsinki and Turku, Finland Does low-dose a n t i c o a g u l a t i o n r e d u c e t h e r i s k of p a n c r e a t i t i s after endoscopic s p h i n c t e r o t o m y ? (Abstract# G2006) T Rabenstein, C Ell, HT Schneider, B Framke and EG Hahn. Erlangen-Nuremberg and Wiesbaden, Germany Acute h y p e r l i p e m i c p a n c r e a t i t i s : a d i f f e r e n t c l i n i c a l entity. (Abstract# G1996) A Pefia, I Paxcual, D Bautista, V Sanchiz, J Sempere, JMG Willatt, M Minguez, F Mora, L Aparisi and A Benages. Valencia, Spain P a n c r e a t i c duct s t e n t i n g decreases t h e i n c i d e n c e of post-ERCP p a n c r e a t i t i s : a prospective r a n d o m i z e d study. (Abstract# G1967) SM Meyerson, JE Geenen, GK Johnson, MF Catalano, DJ Geenen, MJ Schmalz and WJ Hogan, Milwaukee, WI P r e d i c t i n g l e n g t h of stay i n acute p a n c r e a t i t i s with a n e u r a l network. (Abstract# G2000) WE Pofahl, SM Walczak and E Rhone. Mobile, AL I m p a i r e d exocrine p a n c r e a t i c f u n c t i o n i n p a t i e n t s with septic shock. (Abstract# G2054) B Tribl, C Madl, P Mazal, K Ratheiser, H Vogelsang and A Gangl. Vienna, Austria Severity p r e d i c t i o n by i n d i v i d u a l p r o b a b i l i t y i n d e x of complications i n acute p a n c r e a t i t i s . (Abstract# G1922) CD Johnson, S Phillips, SKC Toh and M MuUee. Southampton, United Kingdom E v a l u a t i o n of r e c u r r e n t i d i o p a t h i c p a n c r e a t i t i s i n elderly p a t i e n t s f r e q u e n t l y detects specific etiologies. (Abstract# G2066) RP Venu, RD Brown, P Malik, P Oshin and D Silas. Chicago, IL Cytokines a n d p r o c a l c i t o n i n i n E R C P - i n d u c e d p a n c r e a t i c damage. (Abstract# G1902) P Hardt, O Kress, T Fadgyas, M Oezcueruemez, D Kunz, S Westphal, C Luley and HU Kloer. Giessen and Magdeburg, Germany Admission p l a s m a c h o l e c y s t o k i n i n levels are low b o t h i n acute: alcoholic a n d b i l i a r y p a n c r e a t i t i s . (Abstract# G2008) S R~ity, J Sand, E Kemppainen, S Laine and I Nordback. Tampere, Finland Significant cost r e d u c t i o n due to c l i n i c a l g u i d e l i n e s i n mild a c u t e p a n c r e a t i t i s . (Abstract# G2071) W Wassef, S Choi, J Fitch, A Zfass and M Nettleman. Richmond, VA A l t e r a t i o n of fibroblast growth factor e x p r e s s i o n following acute p a n c r e a t i t i s . (Abstract# G1849) M Ebert, M Yokoyama, T Ishiwata, H Friess, M Bfichler, P Malfertheiner and M Korc. Magdeburg, Germany; Irvine, CA and Bern, Switzerland Severe acute p a n c r e a t i t i s is associated w i t h a rise i n s e r u m endothelin-l,2. (Abstract# G1949) MPN Lewis, M Watson, WSL Stebbings, CTM Speakman and M Rhodes. Norwich, United Kingdom

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A G A P O S T E R S E S S I O N - - T U E S D A Y , MAY 19, 1998 Acute b i l i a r y p a n c r e a t i t i s : the significance of m o r p h o l o g i c a l c h a r a c t e r i s t i c s i n b i l i a r y lithiasis. (Abstract# G1995) I Pascual, A Pefia, I Ortega, M Minguez, F Mora, J Sempere, V Sanchiz, D Bautista, JMG Wfllatt, L Aparisi and A Benages. Valencia, Spain P y r i d i u m cross links, IL-6 a n d IL-8 levels i n acute p a n c r e a t i t i s . (Abstract# G1968) A Miah, S Nandi, B Bailey and S Bank. New Hyde Park, NY P r e d i c t i o n of c o m m o n bile d u c t stones a n d c o m p l i c a t i o n s i n gallstone p a n c r e a t i t i s u s i n g early l a b o r a t o r y t r e n d s . (Abstract# G1825) ME Cohen, CK Wells and M Topazian. New Haven, CT The r i s k of p a n c r e a t i c a d e n o c a r c i n o m a i n p a t i e n t s with c h r o n i c p a n c r e a t i t i s : m y t h or reality? (Abstract# G1958) I Madeira, F Pessione, D Malka, P Hammel, P Ruszniewski and P Bernades. Clichy, France Is t h e a s s o c i a t i o n of s e r u m lipase w i t h [~2-microglobulin

or w i t h C-reactive p r o t e i n useful i n s i m u l t a n e o u s l y e s t a b l i s h i n g the d i a g n o s i s a n d prognosis of p a t i e n t s w i t h a c u t e p a n c r e a t i t i s ? (Abstract# G1998) R Pezzilli, AM Morselli Labate, B Barakat, M Fiocchi, O Cappelletti and F Miglio. Bologna, Italy

DDW Poster of Distinction: Is c o n t r a s t - e n h a n c e d c o m p u t e d t o m o g r a p h y useful for t h e e a r l y r e c o g n i t i o n of severe acute p a n c r e a t i t i s ? (Abstract# G1997) R Pezzflli, P Innocenti, F Miglio, M Miglioli and the GISPAC (Italian Group for the Study of Acute Pancreatitis). Bologna, Italy CD8+CD103+ T cells a n a l o g o u s to i n t e s t i n a l i n t r a e p i t h e l i a l l y m p h o c y t e s i n f i l t r a t e the p a n c r e a s i n c h r o n i c p a n c r e a t i t i s . (Abstract# G1850) M Ebert, K Ademmer, F Miiller, H Friess, M Btichler, W Schubert and P Malfertheiner. Magdeburg, Germany and Bern, Switzerland I n t r a l u m i n a l gastric a n d d u o d e n a l pH i n c h r o n i c p a n c r e a t i t i s . (Abstract# G1876) WP Geus, EH Eddes, HAJ Gielkens, CBHW Lamers and AAM Masclee. Leiden and The Hague, The Netherlands N i t r o g l y c e r i n r e s i s t a n c e of the gallbladder: feeble b i o c o n v e r s i o n to n i t r i c oxide. (Abstract# G2046) Z Szilv~ssy, I Nagy, P Ferdinandy and J Lonovics. Szeged, Hungary E n d o s c o p i c t h e r a p y i n c h i l d r e n with p a n c r e a s d i v i s u m p r e s e n t i n g w i t h a c u t e p a n c r e a t i t i s or c h r o n i c a b d o m i n a l p a i n . (Abstract# G1812) MF Catalano, FN Khan, WJ Hogan and JE Geenen. Milwaukee, WI Does a p a n c r e a t i c c o m p a r t m e n t s y n d r o m e cause p a i n i n c h r o n i c p a n c r e a t i t i s ? Analysis of the m i c r o c i r c u l a t i o n i n v/vo. (Abstract# G1933) WT Knoefel, JC Limmer, JR Izbicki, C Bloechle, M Gundlach and CE Broelsch. Hamburg, Germany Does i d i o p a t h i c a c u t e p a n c r e a t i t i s really exist? Results of a long t e r m follow-up after ERCP/EST. (Abstract# G1810) S Caporuscio, F Lella, F Bagnolo, E Colombo, U Bonassi and PA Testoni. Zingonia and Milan, Italy G r o w t h factors F G F a n d P D G F expression is n o t c o r r e l a t e d to t h e g e n e r a t i o n of a n i n f l a m m a t o r y mass i n c h r o n i c p a n c r e a t i t i s . (Abstract# G2016) I Scheurlen, C Bloechle, M Stabenow, H Sauer, WT Knoefel and JR Izbicki. Hamburg, Germany

DDW Poster of Distinction: A clinical s t u d y of a u t o i m m u n e - r e l a t e d c h r o n i c p a n c r e a t i t i s . (Abstract# G1989) K Okazaki, K Uchida and T Chiba. Kyoto, Japan

DDW Poster of Distinction: P a n c r e a t i c zinc o u t p u t as a simple m a r k e r for e v a l u a t i n g exocrine p a n c r e a t i c f u n c t i o n . (Abstract# G1845) JE Dominguez-Mufioz, A Leodolter, S Martinez, G Manes and P Malfertheiner. Magdeburg, Germany I n c r e a s e d chromosome i n s t a b i l i t y i n p a t i e n t s with c h r o n i c p a n c r e a t i t i s . (Abstract# G1829) A Cottliar, C Morfin, J Gomez, S Martinez, N Chopita, P Geldern, N Landoni, E Sosa, A Fundia, A Berredo, L Boerr and I Slavutsky. Burnos Aires and La Plata, Argentina Effect of clinical doses of p o r c i n e or b a c t e r i a l lipase with a h i g h fat diet o n fat a b s o r p t i o n a n d b i o a v a i l a b i l i t y of lipolytic a c t i v i t y i n c a n i n e p a n c r e a t i c insufficiency. (Abstract# G1823) JP Chung, A Metzger, N Asakura, MG Sarr and EP DiMagno. Rochester, MN I n t r a g a s t r i c a n d d u o d e n a l lipolysis is i m p o r t a n t for fat a b s o r p t i o n i n u n t r e a t e d a n d t r e a t e d c a n i n e exocrine insufficiency. (Abstract# G1784) N Asakura, JP Chung and EP DiMagno. Rochester, MN Lack of R l l 7 H m u t a t i o n i n t h e c a t i o n i c t r y p s i n o g e n gene i n p a t i e n t s with t r o p i c a l p a n c r e a t i t i s from Bangladesh. (Abstract# G20U) L Rossi, DC Whitc0mb, GD Ehrlich, S Parvin, AK Azad Khan and K Gyr. Basel, Switzerland; Dhaka, Bangladesh and Pittsburgh, PA High s e r u m levels of s e c r e t o r y i m m u n o g l o b u l i n A i n a d v a n c e d c h r o n i c p a n c r e a t i t i s . (Abstract# G1869) L Frulloni, M Negri, M Zanini, P Bovo, S Brunelli, V DiFrancesco, B Vaona, M Filippini, MP Brunori, PC Farris, B Calore and G Cavallini, Verona, Italy Changes i n cytokine b u t n o t t a c h y k i n i n gene expression i n p a t i e n t s w i t h c h r o n i c p a n c r e a t i t i s . (Abstract# G1842) P Di Sebastiano, C Di Febbo, FF di Mola, G Baccante, E Porreca, P Innocenti, H Friess and MW Biichler. Chieti, Italy and Bern, Switzerland BILIARY DISORDERS - - GALLSTONES AND OTHER BILIARY DISEASE

DDW Poster of Distinction: A c o m p a r i s o n of cholesterol c r y s t a l l i z a t i o n c o n t r o l l i n g factors i n gallbladder biles from C h i l e a n a n d D u t c h gallstone p a t i e n t s . (Abstract# G2171) J-F Miguel, F Nervi, Y Keulemans, KS Mok and AK Groen. Santiago, Chile and Amsterdam The Netherlands

DDW Poster of Distinction: I m m u n o f l u o r e s c e n c e s t u d i e s of b i l i a r y "sludge" i n p a t i e n t s w i t h gallstones. (Abstract# G2156) P Lech~ne de la Porte, H Lafont, N Domingo, G Meyer, I Mfiller and D Jiingst. Marseille, France and Munich, Germany

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D D W Poster of Distinction: A c c u r a t e q u a n t i f i c a t i o n of cholesterol-solubilizing particles in h u m a n gallbladder and h e p a t i c biles: p o t e n t i a l i m p l i c a t i o n s for g a l l s t o n e formation. (Abstract# G2121) ERM Eckhardt, W Renooij, MBM de Smet, PMNYH Go, KJ van Erpecum and GP van Berge Henegouwen. Utrecht and Nieuwegein, The Netherlands I n c r e a s e d r i s k of cholesterol gallstone f o r m a t i o n i n subjects with a p o l i p o p r o t e i n E4 genotype: its r e l a t i o n to bile c o m p o s i t i o n a n d crystallization. (Abstract# G2239) KJ van Erpecum, P Portincasa, ERM Eckhardt, BJM van de Heijning, AK Groen and GP van Berge Henegouwen. Utrecht and Amsterdam, The Netherlands; Bari, Italy The effects of p h o s p h o l i p a s e A2, free fatty acids a n d l y s o p h o s p h a t i d y l c h o l i n e o n the c r y s t a l l i z a t i o n of cholesterol i n g a l l b l a d d e r bile. (Abstract# G2208) A Sch6ne, D J~ingst, T Hernandez-Richter and S Fischer. Munich, Germany I n c r e a s e s i n l u m i n a l p H p r o m o t e the a b s o r p t i o n of deoxycholic acid from the colon of p a t i e n t s w i t h cholesterol g a l l b l a d d e r stones. (Abstract# G2231) LA Thomas, T Bathgate, MJ Veysey, A King, GL French, GM Murphy and RH Dowling. London, United Kingdom Roles of colonic t r a n s i t , bacteriology, bile acid m e t a b o l i s i n g e n z y m e s a n d deoxycholic acid i n the p a t h o g e n e s i s of gallstones a n d colorectal cancer, i n acromegalic p a t i e n t s before a n d d u r i n g octreotide t r e a t m e n t . (Abstract# G2233) LA Thomas, T Bathgate, MJ Veysey, J Powrie, D RussellJones, JA Wass, A King, GL French, GM Murphy and RH Dowling. London and Oxford, United Kingdom

-- TUESDAY,

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19, 1998

T r a n s i t i o n m e t a l s are p r e f e r e n t i a l l y p r e c i p i t a t e d i n the cores of solitary cholesterol gallstones. (Abstract# G2144) HS Kaufman, KP Murray, JH Shin, P Frasca, P Laraia, PA Lipsett, KD Lillemoe and HA Pitt. Baltimore, MD; Milwaukee, WI and Westmont, NJ The effect of c o m b i n e d t r e a t m e n t w i t h ursodeoxycholic acid a n d p r a v a s t a t i n on h e p a t i c cholesterol m e t a b o l i s m a n d b i l i a r y lipids i n gallstone p a t i e n t s . (Abstract# G2132) C-G Hillebrant, I BjSrkhem, C Eiarsson, M Rudling and B Nyberg. Stockholm, Sweden Does d i e t a r y fish oil p r e v e n t cholesterol gallstone f o r m a t i o n i n i n b r e d mice? (Abstract# G2169) N M~ndez-Sfinchez, G Ponciano-Rodriguez, I Gracia and M Uribe. Mexico City, Mexico R e g u l a r food diet (1200 KcaYd) p r e v e n t s cholesterol gallstone f o r m a t i o n i n obese p a t i e n t s d u r i n g weight loss a n d this effect is i m p r o v e d b y s u p p l e m e n t a t i o n of N-3 p o l y n s a t u r a t e d fatty acids. (Abstract# G2170) N M~ndez-S~nchez, V G0nzfilez, P Aguayo, JM Sfinchez, MA Tanimoto, J Elizondo and M Uribe. Mexico City, Mexico I n f l u e n c e of t h e m a i n c o m p o n e n t s i n bile o n the p r e c i p i t a t i o n p a t t e r n i n a n a g a r gel system: t h e c o n c e n t r a t i o n of metal ions a n d the a d d i t i o n of b i l i r u b i n , cholesterol, a n d lecithin. (Abstract# G2253) Z-L Yang, RD Soloway, GJ Somjen, J Tao, Y Sun, L-Y Zheng, S0F Weng and J-G Wu. Beijing, PR China; Tel Aviv, Israel and Galveston, TX A p o l i p o p r o t e i n E4 genotype is associated w i t h i n c r e a s e d lithogenic factors i n g a l l b l a d d e r bile of p a t i e n t s with gallstones. (Abstract# G2118) MH Dolu, ERM Eckhardt, GM Dallinga-Thie, E Frimberger and D Jiingst. Munich, Germany and Utrecht, The Netherlands

Is c h o l e l i t h i a s i s an i n t e s t i n a l disease? Multivariate a n a l y s e s of five p a t h o g e n e t i c factors. (Abstract# G2232) LA Thomas, T Bathgate, MJ Veysey, N Smeeton, GL French, GM Murphy and RH Dowling. London, United Kingdom

A novel p r o n u c l e a t i n g g l y c o p r o t e i n i n h u m a n gallbladder bile. (Abstract# G2226) RK Tandon, AK Basak and VS Thakur. New Delhi, India

H u m a n biliary glycoprotein and calcium bilirubinate b o t h change m o l e c u l a r c o n f i g u r a t i o n following b i n d i n g i n s o l u t i o n in vitro.. (Abstract# G2213) G-R Shen, RD Sol0way, Y-H Shen, S-F Weng, W-H Li and JG Wu. Beijing, PR China and Galveston, TX

H u m a n spasmolytic p o l y p e p t i d e s i g n i f i c a n t l y e n h a n c e s the cholesterol crystal n u c l e a t i n g p r o p e r t i e s of m u c i n . (Abstract# L0470) DP Nunes, L Thim, N Nui, NH Afdhal and GD Offner. Boston, MA

C o m p l e m e n t a r y i m p o r t a n c e of bile salts a n d p h o s p h a t i d y l c h o l i n e i n b i n d i n g m a g n e s i u m to micelles a n d bilayers. (Abstract# G2119) JM D0novan and AA Jackson. Boston, MA

P i g m e n t a n d cholesterol gallstones differ i n t h e i r biometal content. (Abstract# G2179) KP Murray, HS Kaufman, JH Shin, P Laraia, P Frasca, PA Lipsett, KD Lillemoe and HA Pitt. Baltimore, MD; Milwaukee, WI and Westmont, NJ

The growth of p e r i o d i c c a l c i u m b i l i r u b i n a t e r i n g s following a n d s u p e r i m p o s e d u p o n the fractal (chaotic) p r e c i p i t a t i o n of c a l c i u m deoxycholate i n a n agar gel system. (Abstract# G2252) Z Yang, RD Soloway, S Weng, X Zhang, DR Taylor and JG Wu. Beijing, PR China and Galveston, TX

II II

The effects of octreotide o n the k i n e t i c s of deoxycholic a n d cholic acid. (Abstract# G2243) MJ Veysey, A Mallet, P Jenkins, GM Besser, GM Murphy and RH Dowling. London, United Kingdom

Does a n h y d r o u s cholesterol exist i n m a t u r e gallstones? (Abstract# G2229) DR Taylor, JW Wen, RD Soloway, WH Nealon, WK Gourley, Y-Z Xu and J-G Wu. Galveston, TX and Beijing, PR China

I n f r a r e d spectral a n d s t r u c t u r a l differences b e t w e e n urso- a n d chenodeoxycholic acids. (Abstract# L0694) Y-Z Xu, RD Soloway, LA Nafie, S-F Weng, Z-L Yang, G Ma and J-G Wu. Beijing, PR China; Galveston, TX and Syracuse, NY

Cholesterol p r e c i p i t a t i o n : a n h y d r o u s versus m o n o h y d r a t e : effects of i n c r e a s i n g solute c o n c e n t r a t i o n a n d w a t e r v a p o r access i n a s a t u r a t e d cholesterol: i s o p r o p a n o l system. (Abstract# G2228) DR Taylor, Y-Z Xu, JW Wen, J-G wu and RD Soloway. Galveston, TX and Beijing, PR China

I n f l u e n c e of fructose a n d a l b u m i n o n the p a t t e r n of cobalt deoxycholate p r e c i p i t a t i o n i n agar gel. (Abstract# G2263) Y Zhao, RD S01oway, Y-Y Song, L-M Yang, J-G Wu and GX Xu. Beijing, PR China and Galveston, TX

April 1998

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Modification of p e r i o d i c a n d fractal p r e c i p i t a t i o n i n a bile salt: m e t a l chloride p r e c i p i t a t i o n system. (Abstract# G2249) D-T Xie, RD S01oway, J-G Wu, GJ S0mjen, Q Peng and GX Xu. Beijing, PR China; Tel Aviv, Israel and Galveston, TX

Loss of FHITgene e x p r e s s i o n i n p a n c r e a t i c c a r c i n o m a cells. (Abstract# G2809) B Simon, D Bartsch, P Barth, N Prasnika, R Arnold and B G6ke. Marburg, Germany

Risk of gallstone disease is associated to s e r u m level of a l p h a - l - a c i d glycoprotein. (Abstract# G2230) CT Thijs, M Hovens and AK Groen. Maastricht and Amsterdam, The Netherlands

tpr~metrearrangement i n gastric a d e n o c a r c i n o m a s . (Abstract# G2463) J Garay, P Collins, J Torrado, B Ruiz, G Wogan and P Correa. New Orleans, LA, Cambridge, MA and San Sebastian, Spain

I d e n t i f i c a t i o n of 3~-hydroxy-5-cholesten-26,27dicarboxylic acid, a novel p r o d u c t formed w h e n cholesterol is i n c u b a t e d w i t h h u m a n m o n o n u c l e a r leukocytes. (Abstract# G2099) AK Batta, LB Nguyen, S Shefer and G Salen. Newark and East Orange, NJ

DDW Poster of Distinction:

S-adenosyl-L-methionine protects a n d reverses t u a r o l i t h o c h o l a t e - i n d u c e d cholestasis: a s t u d y i n isolated r a t h e p a t o c y t e couplets. (Abstract# L0422) P Milkiewicz, J Ahmed-Choudhury, CO Mills, E Elias and R Coleman. Birmingham, United Kingdom

A role for the t y r o s i n e k i n a s e s cSrc a n d eyes i n the p r o g r e s s i o n of p r i m a r y colonic a d e n o c a r c i n o m a s . (Abstract# G2309) C B6nistant, J-F Bourgaux, C Pignodel, J-L Balm~s, J-P Bali and S Roche. Nimes, France

D e t e c t i o n of Helicobacter DNA i n t h e bile from the o b s t r u c t e d bile duct. (Abstract# G2146) JT Kim, IH Roe, YJ Jin, JH Shin and JH Lee. Chunan, Korea

The o n c o p r o t e i n p185Her-2 activates the isozyme II of c a r b o n i c a n h y d r a s e . (Abstract# G2624) A Maghiar, T Maghiar, G Mermeze, O Micle and I Pu~ca@. Simleu Silvaniei, Romania

DDW Poster of Distinction:

T r a n s c r i p t i o n a l a n d t r a n s l a t i o n a l r e g u l a t i o n of apobec1, a novel p r o t o o n c o g e n e expressed i n h u m a n a n d r a t i n t e s t i n e . (Abstract# G2277) S Anant, K Hirano, SF Skarosi, TA Brasitus and NO Davidson. Chicago, IL

C o m m o n bile d u c t l i g a t i o n u p r e g u l a t e s g u i n e a pig g a l l b l a d d e r e i c o s a n o i d release a n d synthesis. (Abstract# G2101) L Bogar, L Bartula, HP Parkman and SI Myers. Philadelphia, PA Are the c o m m o n bile d u c t d i a m e t e r a n d wall thickness r e l a t e d to the d e v e l o p m e n t of septic cholangitis i n p a t i e n t s w i t h c o m m o n bile d u c t stones? (Abstract# G2211) DW Seo, JS Kim, HJ Kim, SJ Myung, KH Yoon, YK Jung, YS Kim, SK Lee, MH Kim and YI Min. Seoul, Korea Bacteriological s t u d y of bile i n p a t i e n t s with c h o l a n g i t i s due to b i l i a r y t r a c t o b s t r u c t i o n . (Abstract# G2224) IK Sung, KT Lee, JK Lee, HJ Son, JH Lee, PL Rhee, J Kim, KC Koh, SW Paik, JC Rhee and KW Ch0i. Se0ul, Korea

c-kit gene i n g a s t r o i n t e s t i n a l s t r o m a l t u m o r . (Abstract# G2686) M Nakahara, K Isozaki, S Hirota, Y Shinomura and Y Matsuzawa. Osaka, Japan

A novel gain-of-function m u t a t i o n of

CDX1 is d o w n r e g u l a t e d i n colon c a n c e r cells a n d e x p r e s s i o n i n h i b i t s growth. (Abstract# G2925) D Yang, J Lynch, D Silberg, E-R Suh and PG Traber. Philadelphia, PA

DDW Poster of Distinction: Amplification of 17q12-21 i n s p o r a d i c gastric c a r c i n o m a s b u t n o t i n gastric c a r c i n o m a from p a t i e n t s with h e r e d i t a r y n o n p o l y p o s i s colorectal cancer. (Abstract# G2265) M Aarni0, A K0kkola, P Puolakkainen, ML Larramendy, W E1-Rifail, O Monni, E Kivilaakso and S Knuutila. Helsinki, Finland

The t i m e course of histological p r o g r e s s i o n i n p r i m a r y s c l e r o s i n g cholangitis. (Abstract# L0023) P Angulo, TM Therneau, DR Larson, KP Batts, NF LaRusso and KD Lindor. Rochester, MN

Microsatellite i n s t a b i l i t y i n gastric c a r c i n o m a : r e l a t i o n to t u m o r type, stage a n d site i n the stomach. (Abstract# G2595) F Kullmann, VD Mohr, S Mehringer, K-W Jauch, J Sch~lmerich and J Rfischoff. Regensburg, Germany

G A S T R O I N T E S T I N A L ONCOLOGY - - MOLECULAR G E N E T I C S OF GASTROINTESTINAL CANCER II

The r e l a t i o n s h i p a m o n g HBV genome i n t e g r a t i o n , p53 gene m u t a t i o n , t e l o m e r a s e activity a n d genetic i n s t a b i l i t y i n HBsAg-negative a n d anti-HCV positive h e p a t o c e l l u l a r c a r c i n o m a i n J a p a n . (Abstract# L0406) Y Matsuzaki, T Chiba, Y Saito, M Doy, S Itoh, H Asaoka, J Shoda and N Tanaka. Ibaraki and Tokushima, Japan

Deletions of pl6/MTS-1 gene is a f r e q u e n t event i n p a n c r e a t i c j u i c e from p a t i e n t s w i t h p a n c r e a t i c c a n c e r a n d c h r o n i c p a n c r e a t i t i s . (Abstract# G2322) M Bouisson, P Pages, L Buscail, O Croizet, C Bureau, P Berth61emy, J Fourcade, N Vaysse, J Escourrou and L Pradayrol. Toulouse, France E l e v a t e d p R b is associated w i t h elevated E2F-1 b u t n o t cyclin D1 or c y c l i n - d e p e n d e n t k i n a s e 4 i n the colorectal c a r c i n o m a cell cycle. (Abstract# G2612) H Lemass, E Ryan, P MacMathuna, J Crowe and JC O'Keane. Dublin, Ireland Q18E m u t a t i o n of Op18 detected i n a gastric cardia t u m o r i n h i b i t s cell differentiation. (Abstract# G2359) CL Chang, RF Melhem, DG Beer, R Kuick, R Hinderer and SM Hanash. San Diego, CA and Ann Arbor, MI

DNA m i s m a t c h r e p a i r e n z y m e (MLH1) s t a t u s of a b e r r a n t crypt loci a n d small polyps associated w i t h MLHl-negative colon a d e n o c a r c i n o m a . (Abstract# G2339) LJ Burgart, L Wang, PC Roche, DJ Tester and SN Thibodeau. Rochester, MN ' ~ l e p l i c a t i o n error" p h e n o t y p e a n d " m i s m a t c h r e p a i r " gene defects i n s p o r a d i c colorectal c a n c e r at early onset. (Abstract# G2448) M Fornasarig, A Viel, E Cap0zzi, R Sigon, A De Paoli, M Boiocchi and M Valentini. Aviano, Italy

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A G A P O S T E R S E S S I O N - - T U E S D A Y , MAY 19, 1998 p27 Kwl e x p r e s s i o n i n v e r s e l y correlates w i t h m i c r o s a t e l l i t e i n s t a b i l i t y a n d TGF-~ r e c e p t o r type II m u t a t i o n s i n s p o r a d i c colon cancer. (Abstract# G2619) DF Liu, WM Grady, A Rajput, S Markowitz and J Willis. Cleveland, OH

Effect of interferonoy o n g r o w t h a n d cell cycle p r o g r e s s i o n of stomach c a n c e r cells. (Abstract# G2610) SJ Lee, HJ Chun, YT Jeen, KH Kim, HJ Park, SH Urn, SW Lee, JH Choi, CD Kim, HS Ryu, JH Hyun and JW Sohn. Seoul, Korea

The wild type APC allele is n o t lost i n FAP-associated t h y r o i d t u m o r s , s h o w i n g a c t i v a t i o n of t h e chimeric oncogene ret-PTC. (Abstract# L0092) F Cetta, G Montalto, M Petracci, M Gori, C Baldi, MC Curia, P Battista, A Cama and RM Constantini. Siena and Chieti, Italy

G r o w t h d e p e n d e n c y of a n o v e l h u m a n p a n c r e a t i c c a n c e r cell line, YAPC, o n a u t o c r i n e i n t e r l e u k i n - l a s t i m u l a t i o n . (Abstract# G2920) T Yamada, S Ohwada, I Takeyoshi, Y Kawashima, T Ogawa, T Ohya, K Kawashima, S Kawate, Y Nakasone, K Arai, M Aiba, Y Morishita, F Okajima and Y Kondo. Maebashi, Japan

H e p a t o b l a s t o m a a n d t h y r o i d c a r c i n o m a co-segregate w i t h c o n g e n i t a l h y p e r t r o p h y of t h e r e t i n a l p i g m e n t e p i t h e l i u m i n p a t i e n t s w i t h familial a d e n o m a t o u s polyposis. (Abstract# G2355) F Cetta, G Morgese, M Petracci, S Olschwang, P Battista, A Acquaviva, M Zuckermann, C Baldi, D Cetta and G Montalto. Siena, Paris and Chieti, Italy

I n d u c t i o n of i n t e r l e u k i n - 6 from h u m a n gastric epithelial cell line MKN-28 a n d the s i g n a l p a t h w a y is mediated by protein tyrosine kinase and d e x a m e t h a s o n e - s e n s i t i v e m e c h a n i s m . (Abstract# G2396) SZ Ding, CH Cho and SK Lam. H0ng Kong, China

GASTROINTESTINAL ONCOLOGY - - REGULATION OF PROLIFERATION, D I F F E R E N T I A T I O N AND APOPTOSIS Ttunor-derived m y o f i b r o b l a s t s are able to increase LoVo h u m a n colon c a r c i n o m a cells p r o l i f e r a t i o n before t r a n s f o r m a t i o n : i m p o r t a n c e of m e s e n c h y m a l cells p h e n o t y p e . (Abstract# G24U) J Dumortier, C Ratineau, C Roche, MF Jacquier, L Remy and JA Chayvialle. Lyon, France

DDW Poster of Distinction: P r i m a r y a d u l t h u m a n colonic s u b e p i t h e l i a l myofibroblasts i n d u c e m o r p h o l o g i c a l a n d cytological d i f f e r e n t i a t i o n i n T84 colonic epithelial cells. (Abstract# G2393) R Del Buono, J Beltinger, L Jackson, CJ Hawkey and YR Mahida. Nottingham, United Kingdom The b i n d i n g c h a r a c t e r i s t i c s a n d effects o n n u c l e a r p r o t e i n i m p o r t i n HT29 colon c a n c e r cells of four d i e t a r y T F - b i n d i n g l e c t i n s w i t h c o n t r a s t i n g effects o n epithelial proliferation. (Abstract# G2652) JD Milton, L-G Yu, DG Fernig and JM Rhodes. Liverpool, United Kingdom A f l u o r i n a t e d s y n t h e t i c a n a l o g of v i t a m i n D 3 i n d u c e s G0/G1 a r r e s t i n CaCo-2 cells a n d i n c r e a s e s expression of p21 wafl a n d p27Kip 1. (Abstract# G2777) BA Scaglione-Sewell, S Skarosi, M Bissonnette, M Sitrin and TA Brasitus. Chicago, IL 8-Cl-adenosine i n d u c e s G1 cell cycle a r r e s t i n colorectal carcinomas through p53-dependent and -independent elevations i n p21WAF1/CIP1.(Abstract# G2401) DT Dransfield, LL Burnham, SL Simonton and R Chinery. Augusta, GA and Nashville, TN

TNF-a a n d IL-I~ i n d u c e i n t e r l e u k i n - 8 r e s p o n s e i n h u m a n gastric e p i t h e l i a l cells a n d the s i g n a l p a t h w a y is m e d i a t e d by p r o t e i n t y r o s i n e k i n a s e a n d d e x a m e t h a s o n e - s e n s i t i v e m e c h a n i s m . (Abstract# G2397) SZ Ding, CH Cho, BCY Wong, KC Lai, GKK Lau, WM Hui and SK Lain. Hong Kong, China

H. pylori toxin, TNF-a or LPS i n d u c e IL-8 r e s p o n s e i n e n d o t h e l i a l cells a n d the signal p a t h w a y is m e d i a t e d b y p r o t e i n t y r o s i n e kinase. (Abstract# G0430) SZ Ding, CH Ch0 and SK Lain. H0ng Kong, China TRAIL r e c e p t o r e x p r e s s i o n a n d TRAIL-mediated apoptosis i n h u m a n colon c a r c i n o m a cell lines. (Abstract# G2470) B Gliniak, T Le, M Kubin, C Smith, R G0odwin, D Lynch, M Degli-Esposti and T Griffith. Seattle, WA P h e n y l a r s i n e oxide is a p o t e n t i n h i b i t o r of h e a t shock p r o t e i n i n d u c t i o n i n g a s t r i c epithelial cells. (Abstract# G2656) M Miyoshi, K Rokutan, S Teshima, T Nikawa, K Kishi and K Nakamura. Tokushima and Kyoto, Japan PKC agonists s t i m u l a t e mitogenesis of SNU-C4 colon c a n c e r cells by a u g m e n t i n g a u t o c r i n e s t i m u l a t i o n of e p i d e r m a l growth factor receptor. (Abstract# G2906) SG Weller, IK Klein, R Graves-Deal, G Bogatcheva, R Coffey, Jr and WE Karnes, Jr. Rochester, MS; Nashville, TN and Providence, RI Distinct PKC isoforms m e d i a t e p r o l i f e r a t i v e a n d apoptotic effect o f p h o r b o l esters i n h u m a n colon c a n c e r cell lines. (Abstract# G2905) SG Weller, IK Klein and WE Karnes, Jr. Rochester, MN and Providence, RI

D o w n r e g u l a t i o n of g u t - e n r i c h e d Kriippel-like factor i n colonic neoplasm. (Abstract# G2863) C-C Tseng, J-L Shie, S-F Yet and M-E Lee. Boston, MA

P r o t e i n k i n a s e C 5 d o w n r e g u l a t i o n m e d i a t e s apoptosis i n the a d e n o c a r c i n o m a cell line COLO 205. (Abstract# G2617) AE Lewis, MJS Langman, BCY Wong, D Watters and MC Eggo. Birmingham, United Kingdom and Brisbane, Australia

Fas/Apo 1 a n d interferon-T cooperate to i n d u c e apoptosis i n h u m a n p a n c r e a t i c c a r c i n o m a cell lines. (Abstract# G2394) KM Detjen, EO Riecken and S Rosewicz. Berlin, Germany

Lipid p e r o x i d e - i n d u c e d m i l d oxidative stress e n h a n c e s proliferative activity i n h u m a n colonic CaCo-2 cells. (Abstract# G2474) Y Goto, TG Wang and TY Aw. Shreveport, LA

P r o t e i n k i n a s e C-a i n h i b i t s g r o w t h of h u m a n p a n c r e a t i c c a r c i n o m a cells via p21WAF-mediated i n h i b i t i o n of CDK2 activity. (Abstract# G4659) KM Detjen, FH Brembeck, A Kaiser, EO Riecken and S Rosewicz. Berlin, Germany

Cellular redox i m b a l a n c e , m i t o c h o n d r i a l f u n c t i o n a n d NF-KB a c t i v a t i o n are associated w i t h apoptosis i n d u c e d b y l i p i d peroxides i n h u m a n colonic CaCo-2 cells. (Abstract# G2896) TG Wang, Y Goto and TY Aw. Shreveport, LA

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A G A P O S T E R S E S S I O N - - T U E S D A Y , M A Y 19, 1998 Lipid p e r o x i d e i n d u c e s r e d o x i m b a l a n c e a n d oxidative DNA d a m a g e i n h u m a n colonic CaCo-2 cells. (Abstract# G2751) CA Rhoads, N Sieber and TY Aw. Shreveport, LA

D D W Poster of Distinction:

Effect of p53 overexpression a n d K-ras gene m u t a t i o n s on survival in patients with primary sclerosing cholangitis-associated c h o l a n g i o c a r c i n o m a . (Abstract# G2271) SA Ahrendt, A Rashid, JT Chow, HA Pitt, KF Eisenberger and D Sidransky. Baltimore, MD and Milwaukee, WI

Bcl-2 p r e v e n t s a c t i v a t i o n of Caspase-3 t h a t cleaves DNA-dependent protein kinase in the nucleus during s h o r t - c h a i n f a t t y a c i d - i n d u c e d apoptosis. (Abstract# G2598) R Kumar and M Mandal. Houston, TX

S i m u l t a n e o u s d e t e c t i o n of a n e u p l o i d y a n d p53 gene p r o d u c t i n g a s t r o i n t e s t i n a l m a l i g n a n c y . (Abstract# G2346) K Caca, M Gross and WG Zoller. Munich, Germany

R e s i s t a n c e to b u t y r a t e - i n d u c e d apoptosis a n d d i f f e r e n t i a t i o n d u r i n g s p o n t a n e i o u s CaCo-2 cell d i f f e r e n t i a t i o n . (Abstract# G2630) JM Mariadas0n, KL Rickard and PR Gibson. Victoria, Australia

I m m u n o h i s t o c h e m i c a l a s s e s s m e n t of 17-1A a n d c o m p l e m e n t r e s i s t a n c e factors CD55 a n d CD59 i n liver m e t a s t a s e s of colon cancer. (Abstract# G2528) S Inndorf, SB Hosch, M Lueth, P Scheunemann, K Pantel, WT Knoefel and JR Izbicki. Hamburg and Munich, Germany

S i g n i f i c a n t decrease i n t e l o m e r a s e activity d u r i n g d i f f e r e n t i a t i o n of h u m a n h e p a t o m a cell lines. (Abstract# L0454) M Nakamura, H Saito, H Ebinuma, M Takahashi, F Kanek0, K Wakabayashi, Y Saito and H Ishii. Tokyo, Japan

I n c r e a s e d p e r c e n t a g e of CD16 + n a t u r a l k i l l e r cells i n the p e r i p h e r a l blood of p a t i e n t s w i t h n o n - m e t a s t a t i c colon cancer. (Abstract# G2824) B Stange, NC N~issler, D Bergfeldt-Malinowski, C Wex and P Neuhaus. Berlin, Germany

D i f f e r e n t i a t i o n effect of acyclic r e t i n o i d persists i n the f u t u r e g e n e r a t i o n of h u m a n h e p a t o m a - d e r i v e d cell lines. (Abstract# L0594) Y Shiratori, I Yasuda, M Okuno, M Takemura, M Seishima and H M0riwaki. Gifu, Japan

The e x p r e s s i o n of t o p o i s o m e r a s e IIa a n d Ki-67 i n gastric carcinoma. (Abstract# G2750) JS Rew, C Koo, HS Kim, SK Choi, CS Park and SJ Kim. Kwangju, Korea

C o m p a r a t i v e effects of a n t i o x i d a n t v i t a m i n s C, E a n d ~-carotene o n cell p r o l i f e r a t i o n a n d apoptosis i n a gastric e p i t h e l i a l cell line. (Abstract# G2933) ZW Zhang, S Wilks, D Davis, S Carnaby, P Allen, JF P0schet, SE Patchett and MJG Farthing. London, United Kingdom Resveratrol: a potential chemopreventive agent in h u m a n g a s t r i c cancer. (Abstract# G2291) MJ Atten, BM Attar and 0 Holian. Chicago, IL G A S T R O I N T E S T I N A L ONCOLOGY - - PROGNOSIS AND METASTASIS: CLINICAL STUDIES

D D W Poster of Distinction: T h y m i d y l a t e s y n t h a s e a n d p53 expression p r e d i c t e v e n t free s u r v i v a l b u t n o t the r e s p o n s e to a d j u v a n t c h e m o t h e r a p y of p a t i e n t s w i t h colonic carcinoma. (Abstract# G2661) G Monges, C Milan, A Cr0ue, MD Diebold, JF Flejoa, F Piard, S Prevot, P R0ignot, JC Sab0urin, MH Gi0vannini, D Parriaux and JF Seitz. Marseilles and Dijon, France E x p r e s s i o n of p27/Kipl p r o t e i n at the deepest i n v a s i v e p o r t i o n c o r r e l a t e s w i t h colorectal c a n c e r prognosis. (Abstract# G2837) S Tanaka, K Haruma, Y Hirota, T Tanimoto, T Kimura, M Kunihiro, Y Kitadai, M Yoshihara, K Sumii, G Kajiyama and F Shimamoto. Hiroshima, Japan p53, Wafl, MIB1, bcl-2 as p r o g n o s t i c d e t e r m i n a n t s i n c o m p a r i s o n to first g e n e r a t i o n prognostic factors i n gastric c a r c i n o m a . (Abstract# G2746) K Radebold, R Roberts, PV Kaye, S Isaacs and DM Dent. New Haven, CT The i n c i d e n c e of K-ras c o d o n 12 m u t a t i o n s i n resected distal bile d u c t c a r c i n o m a . What is its diagnostic a n d p r o g n o s t i c value? (Abstract# G2755) AM Rijken, TM van Gulik, MM P01ak, PDJ Sturm, DJ G0uma and GJA Offerhaus. Amsterdam, The Netherlands

E - c a d h e r i n a n d Ki-67 e x p r e s s i o n at t h e deepest invasive p o r t i o n correlates w i t h colorectal c a n c e r prognosis. (Abstract# G2572) T Kimura, S Tanaka, K Haruma, T Tanimoto, M Kunihiro, T Shimizu, Y Kitadai, M Yoshihara, K Sumii, G Kajiyama and F Shimamote. Hiroshima, Japan Cysteine a n d serine p r o t e a s e s i n colorectal cancer. (Abstract# G2508) L Hersz~nyi, M Plebani, P Carraro, M De Paoli, G Roveroni, R Cardin, Z Tulassay, R Naccarato and F Farinati. Budapest, Hungary and Padua, Italy The a c t i v i t y of MMP-2 is i n c r e a s e d i n h u m a n colorectal cancer. (Abstract# G2548) C Keh, T Ismafl, P DeTakats, A Martin, MJO Wakelam and DJ Kerr. Birmingham, United Kingdom P r o t e a s e a c t i v a t i o n does n o t facilitate t u m o r s p r e a d i n esophageal cancer. (Abstract# G2454) H Friess, WH Tang, HU Graber, A Andren-Sandberg, S Franz, A Fukuda, A Zimmermann and MW Biichler. Bern, Switzerland D i s t u r b a n c e i n apoptosis i n f l u e n c e s t h e outcome of p a t i e n t s w i t h p a n c r e a t i c cancer. (Abstract# G2453) H Friess, Z Lu, HU Graber, A Zimmermann, A AndrenSandberg, G Adler, M Korc, RM Schmid and MW Biichler. Bern, Switzerland; Ulm, Germany and Irvine, CA E p i d e r m a l growth factor i m m u n o s t a i n i n g as a p r o g n o s t i c i n d i c a t o r for colon cancer. (Abstract# G2730) S Periskic, S Seiwerth, D Yamini, A Guglietta and M Stamos. Torrance, CA; Zagreb, Croatia and Ann Arbor, MI

D D W Poster of Distinction: CEA specific n e s t e d RT-PCR detects c i r c u l a t i n g c a r c i n o m a cells d u r i n g o p e r a t i o n for gastric a n d b i l i a r y - p a n c r e a t i c c a r c i n o m a s . (Abstract# G2655) F Miyazono, S Taka0, S Hokita, S Natsug0e, M Baba and T Aikou. Kag0shima, Japan

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GASTROENTEROLOGYVol.114~No.4 SESSION

CEA, sialyl Le x, MUC1 expressions at the deepest i n v a s i v e p o r t i o n a n d t h e l i v e r m e t a s t a t i c p o t e n t i a l of colorectal c a r c i n o m a . (Abstract# G2512) Y Hiraga, S Tanaka, K Haruma, M Yoshihara, K Sumii, G Kajiyama, F Shimamoto and N Kohno. Hireshima and Ehime, Japan Clinical a n d p a t h o l o g i c a l p r o g n o s t i c i n d i c a t o r s i n colorectal m u c i n o u s c a r c i n o m a . (Abstract# G2591) K Kubota, T Akasu, S Fujita, Y Moriya and T Shimoda. Tokyo, Japan M u c i n gene e x p r e s s i o n a n d l y m p h n o d e m e t a s t a s i s i n early gastric cancer. (Abstract# G2562) HR Kim, SJ Pang, HY Jung, WS Hong, YI Min, HJ Lee, ES Yu and YS Kim. Seoul, Korea and San Francisco, CA

D D W Poster of Distinction: L y m p h n o d e m e t a s t a s i s i n e a r l y gastric c a n c e r l i m i t e d to m u c o s a l layer. (Abstract# G2561) HR Kim, SJ Pang, HY Chung, SK Yang, WS Hong, YI Min and ES Yu. Seoul, Korea Clinicopathological s t u d y of m u c i n o u s gastric c a r c i n o m a : a m u l t i v a r i a t e analysis. (Abstract# G2917) CY Wu, HZ Yeh, TP Shih and GH Chen. Taichung, Taiwan I m m u n o h i s t o c h e m i c a l s t u d y of sialosyl-Tn a n t i g e n i n gastric c a r c i n o m a . (Abstract# G2374) SR Choi, MH Roh, SY Han and WW Shin. Pusan, Korea P r o g n o s t i c s i g n i f i c a n c e of n u m b e r a n d s t a t i o n of m e t a s t a t i c l y m p h n o d e s i n gastric cancer: n e w TNM classification a n d J a p a n e s e rules. (Abstract# G2272) T Aik0u, S Takao, S Kokita, S Natsugoe, M Baba, F Miyazono and K Droste. Kageshima, Japan and Cologne, Germany

D D W Poster of Distinction: P r o g n o s t i c r e l e v a n c e of s u p e r o x i d e d i s m u t a s e s i n gastric cancer. (Abstract# G2533) AML Janssen, CB Bosman, FJGM Kubben, W van Duijn, MM Oostendorp-van de Ruit, G Griffioen, CBHW Lamers and HW Verspaget. Leiden, The Netherlands A m u r i n e m o d e l for h u m a n p a n c r e a t i c c a n c e r orthotopic i n j e c t i o n of s y n g e n e i c p a n c r e a t i c t u m o r cells. (Abstract# G2667) K Morikane, RM Tempero and MA Hollingsworth. Omaha, NE T h y m i d i n e p h o s p h o r y l a s e plays a n i m p o r t a n t role i n p r o g r e s s i o n of d u c t a l a d e n o c a r c i n o m a of the pancreas. (Abstract# G2836) S Takao, Y Takebayashi, K Sha, M Kitazono, S Natsugoe, S Akiyama and T Aikou. Kagoshima, J a p a n P r o g n o s t i c v a l u e of L a u r ~ n classification a n d c-erbB-2 oncogene o v e r e x p r e s s i o n i n a d e n o c a r c i n o m a of the esophagus a n d g a s t r o e s o p h a g e a l j u n c t i o n . (Abstract# G2736) W Polkowski, JW van Sandick, GJA Offerhaus, FJW Ten Kate, H Obertop and JJB van Lanschot, Amsterdam, The Netherlands R e d u c e d e x p r e s s i o n of p l a k o g l o b i n i n d i c a t e s a n u n f a v o r a b l e p r o g n o s i s i n p a t i e n t s w i t h esophageal cancer. (Abstract# G2519) SB Hosch, NH Stoecklein, JR Izbicki, U Pichlmeier and K Pantel. Hamburg and Munich, Germany

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DDW Poster of Distinction: P r o g n o s t i c significance of microvessel d e n s i t y (angiogenesis) i n esophageal c a r c i n o m a . (Abstract# G2858) C Torres, M Mantel, J Turner, H Wang, A Shahsafaei and RD Odze. Boston, MA Angiogenesis as a m a r k e r of r e c u r r e n c e i n r e c t a l carcinoma. (Abstract# G2502) AG Heriot, S Edwards, C Finlayson and D Kumar. London, United Kingdom The i n f l u e n c e of p r i m a r y colorectal c a n c e r o n i m m u n e function. (Abstract# G2505) AG Heriot, JB Marriott, AG Dalgleish and D Kumar. London, United Kingdom The value of laparoscopic u l t r a s o u n d e v a l u a t i o n for m e t a s t a t i c colorectal cancer. (Abstract# G2292) Y Avni, A Rosen, S Birkenfeld, V Sorin and A Czerniak. Holon, Israel Contrast e c h o l y m p h o g r a p h y u s i n g EUS-guided p u n c t u r e . (Abstract# G2583) S K0jima, H G0te, Y Hirooka, A Itoh, S Hayakawa, Y Watanabe, Y Ishiguro, S Hashimoto, T Hayakawa and Y Naitoh. Nagoya, Japan M u l t i m o d a l t h e r a p e u t i c a l a p p r o a c h for r e c u r r e n t colorectal cancer: analysis of survival. (Abstract# G2353) A Cassano, C Pozzo, DC Corsi, M Mancini, P Tarantini, C Signorelli and C Barone. Rome, Italy GASTROINTESTINAL O N C O L O G Y - -

HELICOBACTER PYLORI: G A S T R O I N T E S T I N A L CANCER

D D W Poster of Distinction: N-methyl-N'-nitro-N-nitro s o g u a n i d i n e - i n d u c e d gastric c a r c i n o m a i n Mongolian gerbils infected w i t h Helicobacterpylori. (Abstract# G2854) M Tokieda, S Honda, T Fujioka, A Moriuchi and M Nasu. Oita, Japan High d i e t a r y salt increases severity of g a s t r i t i s a n d gastric epithelial cell p r o l i f e r a t i o n i n the Helieobaeter mustelae~infected ferret. (Abstract# G2632) RP Marini, CA Dangler, JG Fox, NS Taylor, S Kirchain, XD Wang and RM Russell. Cambridge and Boston, MA

HelJcobacter £eli~infected C57BL/6 mice develop a n altered m u c i n p h e n o t y p e c o n s i s t e n t w i t h i n t e s t i n a l metaplasia. (Abstract# G2390) CA Dangler, JG Fox and TC Wang. Cambridge and Boston, MA

DDW Poster of Distinction: Effects of Helicobacterpylori o n cell cycle, p r o l i f e r a t i o n a n d DNA c o n t e n t of gastric e p i t h e l i a l cells in vitro. (Abstract# G2706) B Obst, S Wagner, I Sobek-Klocke and W Befl. Hannover, Germany I n c r e a s e d cell p r o l i f e r a t i o n i n c h r o n i c Helicobacter pylori-positive gastritis a n d g a s t r i c c a r c i n o m a . (Abstract# G2741) L PrSnai, E Szaleczky, B Molmtr, L Berczi and Z Tulassay. Budapest, Hungary

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A G A P O S T E R S E S S I O N - - T U E S D A Y , M A Y 19, 1998 R e d u c e d apoptosis i n H. pylori-associated gastric i n t e s t i n a l m e t a p l a s i a : a factor i n gastric c a r c i n o g e n e s i s ? (Abstract# G2792) IA Scotiniotis, T Rokkas, EE Furth, JW Plotkin, B Rigas and SJ Shift. Philadelphia, PA; Athens, Greece and New York, NY

DDW Poster of Distinction: Analysis of p53 gene m u t a t i o n s of h u m a n gastric m u c o s a i n f e c t e d w i t h HelJcobacterpylorl. (Abstract# G2678) K Murakami, T Fujioka, T Okimoto, Y Mitsuishi, T Oda, A Nishizono and M Nasu. Los Angeles, CA and Oita, Japan C h r o m o s o m a l a b e r r a t i o n s i n H. pylorl-associated gastric c a n c e r a n a l y z e d b y c o m p a r a t i v e genomic h y b r i d i z a t i o n . (Abstract# G2877) NCT van Grieken, MAJA Hermsen, GA Meyer, EJ Kuipers, ME Craanen, MM Weiss, E Bloemena, JPA Baak and SGM Meuwissen. Amsterdam, The Netherlands

Helicobacterpylori-positive gastric cancer tissues showed i n c r e a s e d m a n g a n e s e superoxide d i s m u t a s e activity a n d mRNA expression. (Abstract# G2362) YW Chang, YI-I Rah, YG YAm, SH Dong, HJ YAm, BH YAm, JI Lee and R Chang. Seoul, Korea

HellcobacterpylorJ i n f e c t i o n a n d gastric carcinoma: a meta-analysis. (Abstract# G2428) GD Eslick and NJ Talley. Newcastle and Sydney, Australia

H. pylorl i n f e c t i o n predisposes to gastric colonization b y o t h e r b a c t e r i a d u r i n g omeprazole t r e a t m e n t . (Abstract# G2910) C Williams, D Gillen, M Hossack, D Gilmore and KEL McColl. Glasgow, Scotland The association of lifestyle a n d d i e t a r y factors with the d e v e l o p m e n t of p r e c a n c e r o u s lesions i n H. pylorlinfected subjects i n China. (Abstract# G2618) SR Lin, JY Sung, ALM Yu, JYL Ching, LY Zhou, CCH Lam, RT Wang, WK Leung, JWY Lau, EKW Ng, W Chao and SCS Chung. Beijing and Hong Kong, PR China S c r e e n i n g for g a s t r i c c a r c i n o m a u s i n g H. pylorl serology. (Abstract# G2433) S Everett, J Davies, M Wilcox, H Sue-Ling, D Johnston and A Axon. Leeds, United Kingdom The effect of H. pylori e r a d i c a t i o n a n d a n t i o x i d a n t v i t a m i n s u p p l e m e n t a t i o n o n gastric mucosal reactive oxygen species d a m a g e a n d gastric j u i c e ascorbic acid. (Abstract# G0481) S Everett, I Drake, K White, D Chalmers, C Schorah and A Axon. Leeds, United Kingdom DNA single s t r a n d b r e a k s are more c o m m o n l y f o u n d i n superficial g a s t r i c e p i t h e l i a l cells. (Abstract# G2432) S Everett, K White, C Schorah and ATR Axon. Leeds, United Kingdom CagA s t a t u s is a s t r o n g p r e d i c t o r as risk factor for gastric a d e n o c a r c i n o m a i n Mexico. (Abstract# G2859) J Torres, G P~rez-P~rez, Y Leal-Herrera and O Mufioz. Mexico City, Mexico and Nashville, TN CagA-positive s t r a i n s i n c r e a s e the risk of gastric c a n c e r i n Hong Kong w i t h m o d e r a t e p r e v a l e n c e of Hellcobaeterpyloriinfection a n d gastric c a n c e r mortality. (Abstract# G2914) BCY Wong, KM Chu, SK Lam, E Kwok, KC Lai, WHC Hu, CK Ching and A Covacci. Hong Kong, China and Siena, Italy

Role of the CagA s t a t u s i n a t r o p h i c gastritis a n d i n t e s t i n a l m e t a p l a s i a i n a high g a s t r i c c a n c e r r i s k r e g i o n i n China. (Abstract# G1360) BCY Wong, SK Lava, CK Ching, J Ho, ST Yuen, E Kwok, WHC Hu, KC Lai, LY Ong, Z Gao, JS Chen, BW Chen, XW Jiang, XH Hou, JY Lu, WH Wang and A Covacci. Hong Kong and Fujian, China; Siena, Italy Age is a p r e d i c t i n g factor for the a s s o c i a t i o n b e t w e e n CaKA-positive Hellcobacterpj~lorl i n f e c t i o n a n d s e r u m p e p s i n o g e n I:II r a t i o i n a high gastric c a n c e r r i s k r e g i o n i n China. (Abstract# G1359) BCY Wong, SK Lain, CK Ching, J Ho, ST Yuen, E Kwok, WHC Hu, KC Lai, LY Ong, Z Gao, JS Chen, BW Chen, XW Jiang, XH Hou, JY Lu, WH Wang, K Miki and A Covacci. Hong Kong and Fujian, China; Tokyo, Japan and Siena, Italy

Helieobacterpylori a l o n e c a n n o t a c c o u n t for d e v e l o p m e n t of a t r o p h i c gastritis a n d i n t e s t i n a l m e t a p l a s i a i n a h i g h gastric c a n c e r r i s k r e g i o n i n China. (Abstract# G2915) BCY Wong, SK Lain, WM Wong, J Ho, ST Yuen, CK Ching, E Kw0k, WHC Hu, KC Lai, LY Ong, Z Gao, JS Chen, BW Chen, XW Jiang, XH Hou, JY Lu and WH Wang. Hong Kong and Fujian, China

Helieobacterpylorlinfection a n d r i s k of gastric c a n c e r i n Korea; c o r r e l a t i o n w i t h a t r o p h i c gastritis a n d i n t e s t i n a l metaplasia. (Abstract# G2567) TH YAm,DK Chang, CH Lee, HC Jung, IS Song and CY YAm. Seoul, Korea

The Helieobacter pylori vacA s l / m l genotype is associated w i t h g a s t r i c c a n c e r i n G e r m a n y . (Abstract# G2649) S Miehlke, A Hackelsberger, C YArsch, N Negraczus, N Lehn, P Malfertheiner and E Bayerd6rffer. Dresden, Magdeburg and Regensburg, Germany P r e v a l e n c e of Helicobaeterpylori infection, i n t e s t i n a l m e t a p l a s i a a n d a t r o p h y i n gastric c a n c e r of different clinical stages. (Abstract# G2648) S Miehlke, A Meining, A Hackelsberger, R Hatz, P Malfertheiner, M Stolte and E Bayerd6rffer. Magdeburg, Munich and Bayreuth, Germany Seroprevalence of Helicobacterpyloriinfection a n d the i n c i d e n c e of gastric c a n c e r i n a m u l t i - e t h n i c p o p u l a t i o n . (Abstract# G2447) KM Fock, CJL Khor, KT Goh, YL Teoh, A Seow, KS Chia, B Ho and HC Ng. Singapore, Singapore Prospective 5 y e a r follow-up of g a s t r i c i n t e s t i n a l m e t a p l a s i a following cure of H. pylori u s i n g a n extensive gastric m u c o s a l bioptic m a p p i n g protocol. (Abstract# G2907) AP Weston, AS Badr, M Topalovski, R Cherian and A Dixon. Kansas City, MO and Kansas City, KS Does e r a d i c a t i o n of H. pylorireverse gastric i n t e s t i n a l m e t a p l a s i a ? Long t e r m follow-up u t i l i z i n g m e t h y l e n e b l u e staining. (Abstract# G2663) TG Morales, RE Sampliner, HS Garewal, E Camarg0 and MB Fennerty. Tucson, AZ and Portland, OR Seroprevalence of HelieobacterpylorJ i n p a t i e n t s w i t h n o n - H o d g k i n s l y m p h o m a : c o m p a r i s o n with other hematological disorders. (Abstract# G2387) J Cuttner, S Itzkowitz, P McGlynn, A Chen, C Bodian, S Ogata and JL Werther. New York, NY

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II D i f f e r e n t i a t i o n of a t y p i c a l gastric l y m p h o i d infiltrates from MALT l y m p h o m a : role of p a r a f f i n section i m m u n o p h e n o t y p i n g . (Abstract# G2420) HMT E1-Zimaity, FAK E1-Zaatari, SM Oweiss, MP Dote, I Shahab, RM Genta, DY Graham and O Gutierrez. Houston, TX and Bogota, Colombia I m m u n o g l o b u l i n h e a v y c h a i n gene sequences a n d t r e a t m e n t o u t c o m e for Helieobaeter py'loriin gastric MALT l y m p h o m a s . (Abstract# G2653) H Miyabayashi, K Fujimori, S Shim0daira, T Akamatsu, K Furihata, K Kiyosawa and T Katsuyama. Matsumoto, Japan C o m p a r t m e n t a n a l y s i s of i m m u n o g i o b u l i n VH r e a r r a n g e m e n t s b y m i c r o d i s s e c t i o n i n p a t i e n t s with MALT l y m p h o m a a n d c h r o n i c gastritis w i t h l y m p h a t i c h y p e r p l a s i a . (Abstract# G2586) M Kraft, N L~igering, H Gockel, W Domschke, P Parwaresch and M Tiemann. Muenster and Kiel, Germany O v e r e x p r e s s i o n of cyclin-B1 a n d p34 k i n a s e cdc2 p r o t e i n s i n H. pylori associated gastric low-grade B cell MALT l y m p h o m a : r e l a t i o n s h i p to cell death, p r o l i f e r a t i o n a n d t r a n s f o r m a t i o n . (Abstract# G2301) SK Banerjee, AP Weston, MN Zoubine and DR Campbell. Kansas City, MO and Kansas City, KS R e g r e s s i o n of g a s t r i c MALT l y m p h o m a after e r a d i c a t i o n of Helicobaeterpylori. A t h r e e year followu p report. (Abstract# G2351) A Caroli, R Follador, F Nic01i, G Vicari0, A Borsato, R D'Este, A Caminiti, P Manente and A Puglisi. Montebelluna, Italy E n d o s o n o g r a p h i c follow-up i n c o n s e r v a t i v e l y t r e a t e d NHL of the s t o m a c h (MALT). (Abstract# G2514) N Hoepffner, T Lahme, J Gilly, P Koch, W Domschke and EC Foerster. Muenster, Germany

Helicobaeterpylorl a n d gastric MALT lymphoma: role of the CagA p r o t e i n . (Abstract# G2851) EM Tkoub, L Deforges, M Levy, D Lamarque, A Lepieard, C Hai0un and JC Delchier. Creteil, France MOTILITY AND N E R V E - G U T INTERACTIONS - E X P E R I M E N T A L MODELS OF SMALL I N T E S T I N E : MOTILITY

DDW Poster of Distinction: Selective c o i n d u c t i o n of cyclooxygenase-2 a n d i n d u c i b l e n i t r i c oxide s y n t h a s e i n h u m a n i n t e s t i n a l smooth m u s c l e d u r i n g a b d o m i n a l surgery. (Abstract# G3188) JC Kalff, MK Eskandari, C Hierholzer, TR Billiar, WH Schraut and AJ Bauer. Pittsburgh, PA

DDW Poster of Distinction:

I Role of VIPz/PACAP receptors i n e x p e r i m e n t a l ileus i n rats. (Abstract# G3066) BY De Winter, P Robberecht, JG De Man, TG M0reels, GE Boeckxstaens, AG Herman and PA Pelckmans. Antwerp and Brussels, Belgium; Amsterdam, The Netherlands Nitric oxide has a k e y role i n g a s t r o i n t e s t i n a l t r a n s i t delay of type I a n d type II diabetic e x p e r i m e n t a l models. (Abstract# G3523) S Weksler-Zangen, J Lysy, M Sestieri and E Goldin: Jerusalem, Israel Role of m a s t cells i n s u r g i c a l l y i n d u c e d g a s t r o i n t e s t i n a l ileus i n mice. (Abstract# G3013) SA Caan, NW Bunnett and HE Raybould. Los Angeles and San Francisco, CA MOTILITY AND N E R V E - G U T I N T E R A C T I O N S - SMALL I N T E S T I N E MOTILITY: CLINICAL SCIENCE

DDW Poster of Distinction: I n t e s t i n a l motility i n c h i l d r e n a n d a d u l t s after small bowel t r a n s p l a n t a t i o n . (Abstract# G3068) C Di Lorenzo, H Mousa, K Abu-Elmgad, J Bueno, J Griffiths, S Kocoshis and J Reyes. Pittsburgh, PA Small bowel m o t i l i t y a n d n a t u r a l h i s t o r y of c h r o n i c i n t e s t i n a l pseudo-obstruction. (Abstract# G3035) R Cogliandro, V Stanghellini, L Cogliandro, R DeGiergi0, G Barbara, B Salvioli and R Corinaldesi. Bologna, Italy Spatio-temporal m a p s of i n t e s t i n a l m o t o r p a t t e r n s . (Abstract# G3150) G Hennig, M Costa, G D'Antona and S Brookes. Adelaide, Australia T h r e e - d i m e n s i o n a l high r e s o l u t i o n m o n i t o r i n g of gastroduodenal transit using magnetic markers. (Abstract# G3190) M Karaus, W Weitschies, D Cordini, L Trahms, W Semmler and B Wiedenmann. Berlin, Germany I n t e s t i n a l t r a n s i t r e s p o n s e to fat i n the p r o x i m a l gut d e p e n d s o n 5 - h y d r o x y t r y p t a m i n e . (Abstract# G3254) HC Lin, XT Zhao and LJ Wang. Los Angeles, CA Nitric oxide p r e v e n t s d u o d e n a l c o n t r a c t i o n s i n d u c e d b y v a r i o u s p o t e n t i a l l y noxious agents. (Abstract# G3149) S Hel!gren, G Flemstr6m and O Nylander. Uppsala, Sweden Can non-histologic t e c h n i q u e s p r e d i c t visceral m y o p a t h i e s or n e u r o p a t h i e s ? (Abstract# G3064) SL Deshmukh, K Nash, J Familoni, D Smalley, G V0eller, P Dean and TL Abell. Memphis, TN Effect of the opioid a n t a g o n i s t LY 246736 o n g a s t r o i n t e s t i n a l t r a n s i t i n h u m a n subjects: (Abstract# G3015) JT Callaghan, B Cerimele, TV Nowak, A DeLong, E Nyhart and S Oldham. Indianapolis, IN

The effects of ABT-229 a n d octreotide o n i n t e r d i g e s t i v e small bowel motility, b a c t e r i a l o v e r g r o w t h a n d b a c t e r i a l t r a n s l o c a t i o n i n rats. (Abstract# G3333) VB Nieuwenhuijs, H van Duijvenbode-Beumer, A Verheem, MR Visser, J Verhoef, HG Gooszen and LMA Akkermans. Utrecht, The Netherlands

Efficacy of i n t e s t i n a l p a c i n g u s i n g a n i n t e s t i n a l feeding tube w i t h r i n g electrodes. (Abstract# G3258) XM Lin, M Zhang, LJ Peters, J Hayes and JDZ Chen. Oklahoma City, OK and Columbus, OH

Nitric oxide s y n t h a s e - I I u p r e g n l a t i o n a n d i n t e s t i n a l p r o p u l s i o n i n a g u i n e a pig model of endotoxic shock. (Abstract# G3089) BR Elliott, D Mailman, WA Weems, NW Weisbr0dt and FG Moody. Houston, TX

I n v o l v e m e n t of 5 - h y d r o x y t r y p t a m i n e i n t h e control of interdigestive gastrointestinal motility in man. (Abstract# G3469) J Tack, B Coulie, R Vos, B Fischler and J Janssens. Leuven, Belgium A n t r o d u o d e n a l m o t i l i t y after d u o d e n u m p r e s e r v i n g r e s e c t i o n of the h e a d of t h e p a n c r e a s . (Abstract# G3087) EH Eddes, J Vecht, MK Vu, CBHW Lamers and AAM Masclee. Leiden, The Netherlands

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A G A P O S T E R S E S S I O N m T U E S D A Y , M A Y 19, 1 9 9 8 I n s u l i n p e r SE modifies g a s t r o i n t e s t i n a l m o t o r reflexes. (Abstract# G3262) T Lingenfelser, R Kadow, WM Sun, T Hinrichs, J Dent and V Gross. Amberg, Germany and Adelaide, Australia R a d i a t i o n - i n d u c e d c h a n g e s i n small i n t e s t i n a l motility: a role for t h e NMDA receptor. (Abstract# G3353) MF Otterson, S Leming, X Liu and J Moulder. Milwaukee, WI The a2-adrenergic r e c e p t o r a g o n i s t clonidine i n d u c e s a p r e m a t u r e i n t e s t i n a l a c t i v i t y f r o n t i n man. (Abstract# G3061) I Demedts, J Tack, R V0s and J Janssens. Leuven, Belgium R a p i d i n t e s t i n a l t r a n s i t i n c h r o n i c p a n c r e a t i t i s is associated w i t h vagal a n d s y m p a t h e t i c d e n e r v a t i o n . (Abstract# G3396) L R0sa-e-Silva, LEA Tr0ncon, RB Oliveira, FJHN Braga, L Gallo, Jr and MC Foss. S~o Paulo, Brazil

Cholesterol m o d u l a t e s g u i n e a p i g g a l l b l a d d e r s m o o t h muscle action p o t e n t i a l c h a r a c t e r i s t i c s . (Abstract# G3181) LJ Jennings, Q-W Xu, MT Nelson and GM Mawe. Burlington, VT Cyclic GMP-mediated a c t i v a t i o n of a glibenclamidesensitive m e c h a n i s m i n the r a b b i t s p h i n c t e r of Oddi. (Abstract# G3269) J Lonovics, Z Szilvassy, I Jakab and I Nagy. Szeged, Hungary Subtypes of m u s c a r i n i c r e c e p t o r s r e g u l a t i n g gallbladder cholinergic c o n t r a c t i o n s . (Abstract# G3366) HP Parkman, AP Pagano and JP Ryan. Philadelphia, PA Regional differences i n m y o g e n i c a n d n e u r o g e n i c p r o p e r t i e s of r a b b i t s p h i n c t e r of Oddi smooth muscle. (Abstract# G3365) HP Parkman, AP Pagano, RM Thomas and JP Ryan. Philadelphia, PA

The small i n t e s t i n a l m o t o r r e s p o n s e to food: v a r i a b i l i t y a n d r e p r o d u c i b i l i t y i n a m b u l a t o r y m a n o m e t r y studies. (Abstract# G3421) T Schmidt, A Pfeiffer, U Exner, R Widmer, C Pehl and H Kaess. Munich, Germany

Latency of the c a n i n e g a l l b l a d d e r p r e s s u r e r e s p o n s e to i n t e s t i n a l s t i m u l a n t s - first results. (Abstract# G3332) E Niebergall-Roth, S Teyssen, K Rippel, A Korn and MV Singer. Mannheim, Germany

X e n i n - a p r o k i n e t i c a g e n t i n the h u m a n j e j u n u m . (Abstract# G3422) T Schmidt, GE Feuerle, P Rummel, H Kaess and A Pfeiffer. Munich and Neuwied, Germany

An e v a l u a t i o n of t h r e e - d i m e n s i o n a l u l t r a s o n o g r a p h y for the s t u d y of g a l l b l a d d e r motility. (Abstract# G3140) S Hashimoto, H Goto, Y Hirooka, A Itoh, S Hayakawa, Y Watanabe, Y Ishiguro, S Kojima, T Hayakawa and Y Naitoh. Nagoya, Japan

The t e m p o r a l r e l a t i o n s h i p b e t w e e n p h a s e III of the m i g r a t i n g m o t o r complex a n d REM sleep. (Abstract# G3168) E Husebye, R Wackerbauer, J Bondi and M Skard Heier. Oslo, Norway and Dresden, Germany T h e p a t t e r n of p r o p a g a t i o n of slow waves affects the

size of spike p a t c h e s i n the isolated d u o d e n u m . (Abstract# G3226) WJEP Lammers, B Stephen and O Pozzan. A1/kin, United Arab Emirates A b n o r m a l i t i e s of a n t r o d u o d e n a l m o t i l i t y i n p a t i e n t s w i t h slow t r a n s i t c o n s t i p a t i o n . (Abstract# G33U) R Mollen, W Hopman, H Kuijpers and J Jansen. Nijmegen, The Netherlands Small bowel m o t i l i t y i n c h r o n i c i d i o p a t h i c c o n s t i p a t i o n . (Abstract# G3368) C Penning, HAJ Gielkens, JBMV Delemarre, WA Bemelman, CBHW Lamers and AAM Masclee. Leiden, The Netherlands A b n o r m a l a n t r o d u o d e n a l m o t i l i t y i n p a t i e n t s with u l c e r a t i v e colitis. (Abstract# G2948) V Annese, F Perri, N Caruso, P Con0scit0re, G Lombardi and A Andriulli. San Giovanni Rotondo, Italy MOTILITY AND N E R V E - G U T INTERACTIONS - GALLBLADDER MOTILITY Excess m e m b r a n e cholesterol alters CCK- a n d VIPi n d u c e d G p r o t e i n a c t i v a t i o n i n h u m a n gallbladders w i t h cholesterol stones. (Abstract# G3532) ZL Xiao, Q Chen, J Amaral, P Biancani and J Behar. Providence, RI Excess m e m b r a n e cholesterol alters CCK r e c e p t o r b i n d i n g affinity a n d c a p a c i t y of h u m a n gallbladder muscle. (Abstract# G3531) ZL Xiao, Q Chen, J Amaral, P Biancani, RT Jensen and J Behar. Providence, RI and Bethesda, MD

Diaspirin crosslinked h u m a n hemoglobin stimulates duodenal and biliary motility with a reduction in transs p h i n c t e r i c flow i n the A u s t r a l i a n B r u s h - t a i l e d possum. (Abstract# G3177) CM Irvine, ACB Meedeniya, H Konomi, AC Schloithe, J Toouli and GTP Saccone. Adelaide, Australia Effect of r e c t a l d i s t e n s i o n o n m e a l - s t i m u l a t e d gallbladder m o t i l i t y a n d p e p t i d e YY release i n h u m a n s . (Abstract# G3500) F van Hoek, RMGH Mollen, WPM Hopman, JHC Kuijpers and JBMJ Jansen. Nijmegen, The Netherlands MOTILITY AND NERVE-GUT INTERACTIONS - COLONIC MOTILITY: BASIC S C I E N C E

D D W Poster of Distinction: Impaired contractile G protein function in a n t r u m and colon c i r c u l a r muscle from p r e g n a n t g u i n e a pigs. (Abstract# G3026) Q Chen, ZL Xiao, P Biancani and J Behar. Providence, RI

D D W Poster of Distinction: C e r a m i d e - i n d u c e d p h o s p h o r y l a t i o n of Hsp27 a n d m o d u l a t i o n of its d i s t r i b u t i o n w i t h i n smooth muscle cells. (Abstract# G3170) AI Ibitayo, G Groblewski and KN Bitar. Ann Arbor, MI C o r t i c o t r o p i n - r e l e a s i n g factor s t i m u l a t e s cecal a n d colonic p r o p u l s i o n a n d m o t i l i t y i n t h e rat. (Abstract# G30U) TF Burks, CC Bihm and CL Williams. Houston, TX Types of a d r e n o r e c e p t o r s m e d i a t i n g r e l a x a t i o n of r a t colonic m u s c u l a r i s m u c o s a e i n v/tro. (Abstract# G3369) WH Percy and RE Burgers. Vermillion, SD Acetic a c i d - i n d u c e d distal colitis i n r a t s decreases colon l o n g i t u d i n a l smooth m u s c l e contractility. (Abstract# G3325) BS Myers, JS Martin, HP Parkman, DT Dempsey and JP Ryan. Philadelphia, PA

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Effects of n o c i c e p t i n / o r p h a n i n FQ o n m o u s e GI t r a n s i t a n d colonic p r o p u l s i v e activity. (Abstract# G3349) MA Osinski, P Bass and EA Gaumnitz. Madison, WI Effect a n d m e c h a n i s m of g l i b e n c l a m i d e on l o n g i t u d i n a l smooth muscle c o n t r a c t i l i t y i n r a t colon. (Abstract# G3028) M-G Choi, M Camilleri, BM Balsiger and G Farrugia. Rochester, MN A l t e r a t i o n of m e m b r a n e p r o p e r t i e s a n d n e u r o m u s c u l a r t r a n s m i s s i o n i n colonic s m o o t h muscle of t h e s p o n t a n e o u s d i a b e t i c rats. (Abstract# G3172) K Imaeda, Y Yokoyama, T Joh, M Itoh and H Suzuki. Nagoya, Japan Motilin- a n d e r y t h r o m y c i n - i n d u c e d Ca2÷-signalling i n myocytes from h u m a n colon. (Abstract# G3492) G Van Assche, I Dep00rtere, P De Clercq, Z Huang, L Missiaen, K Geb0es, F Penninckx, J Janssens and TL Peeters. Leuven, Belgium Abolition of c a r d i o v a g a l r e s p o n s e to colorectal d i s t e n t i o n following n e o n a t a l capsaicin. (Abstract# G3516) L Wang, Y Chert and G Tougas. Hamilton, Canada Changes i n l e u k o t r i e n e D 4 m o d u l a t i o n of smooth muscle c o n t r a c t i l i t y i n a r a t model of colitis. (Abstract# G2995) C Bossone, T Catherwood, VM Pifieiro-Carrero and T SheDonohue. Bethesda, MD The e n t e r o k i n e t i c R093877 n o r m a l i z e s opioid-delayed fecal pellet p r o p u l s i o n i n t h e isolated g u i n e a pig distal colon. (Abstract# G3427) J Schuurkes, A Meulemans, M Briejer, W De Ridder and P De Winter. Beerse, Belgium Effect of ± v e r a p a m i l o n h u m a n colonic smooth muscle i n v/tro. (Abstract# G3153) K Hillier, RA Borman and J Reid. Southampton, United Kingdom Effects of e l e c t r o m a g n e t i c fields o n h u m a n colonic m o t i l i t y i n vitro. (Abstract# G2946) F Angel, F Crenner, C Ringwald, A Klein, E Martin and C Meyer. Strasbourg, France The h e r b a l m e d i c i n e Dai-kenchu-to c o n t r a c t g u i n e a pig distal colon m u s c l e t h r o u g h acetylcholine release. (Abstract# G3221) S Kurosawa, S Nishikawa, M Kaneko, S Ogiwara, S Ro, T Nakamura, K Saito, T Hayakawa, Y Kase and A Ishige. Chiba and Ibaragi, Japan Dual effects of NK3 t a c h y k i n i n receptors a c t i v a t i o n on r a b b i t distal colon p r o p u l s i o n . (Abstract# G3345) L On0ri, G Taddei, A Aggi0, R Cicc0ci0pp0, G Cit0ne, G Frieri and M Tonini. L'Aquila and Pavia, Italy Evidences for a n e w colonic m o t o r p a t t e r n : n o t only p r o p a g a t i n g b u t also s i m u l t a n e o u s high a m p l i t u d e c o n t r a c t i o n s are r e l a t e d to i n t e r n a l a n a l s p h i n c t e r relaxation. (Abstract# G2976) G Bazzocchi, E Conti, R Chattat, M Balloni, SN Reddy, S Reggiani, C Diquattro, D Ravaglia and PR Dal Monte. Bologna, Italy and Hyderabad, India High a m p l i t u d e p r o p a g a t i n g p r e s s u r e wave sequences t o w a r d s a logical definition. (Abstract# G2964) PA Bampt0n, PG Dinning, ML Kennedy, DZ Lub0wski and IJ Cook. Sydney, Australia

The m a n o m e t r i c correlates of s p o n t a n e o u s d e f e c a t i o n i n o b s t r u c t e d defecation: evidence for a p a n c o l o n i c disorder. (Abstract# G2965) PA Bampton, PG Dinning, ML Kennedy, DZ Lubowski and IJ Cook. Sydney, Australia Colonic s c i n t i g r a p h y highlights differences i n subgroups of p a t i e n t s with s l o w - t r a n s i t c o n s t i p a t i o n . (Abstract# G3208) CH Knowles, SM Scott, PJ Lunniss, M Newell, N Garvie and NS Williams. London, United Kingdom The colonic meal r e s p o n s e - i n s i g h t s from u n p r e p a r e d pancolonic multipoint perfusion manometry. (Abstract# G3073) PG Dinning, PA Bampton, ML Kennedy, DZ Lubowski and IJ Cook. Sydney, Australia P r o p a g a t i n g distal ileal m o t o r events: a s t i m u l u s for n o c t u r n a l colonic p r o p a g a t i n g sequences. (Abstract# G3072) PG Dinning, PA Bampton, ML Kennedy, DZ Lubowski and IJ Cook. Sydney, Australia I n v i v o m o d u l a t i o n of left colonic m o t o r f u n c t i o n b y a

5HT 4 m e c h a n i s m i n h e a l t h y h u m a n s . (Abstract# G3513) MR von der Ohe, S Klingenburg and H Goebell. Heidelberg and Essen, Germany D i u r n a l v a r i a t i o n of periodic m o t o r a c t i v i t y i n the h u m a n colon. (Abstract# G3130) R Hagger, D Kumar, M Benson and A Grundy. London, United Kingdom A placebo-controlled s t u d y to e v a l u a t e the effect o n colonic t r a n s i t of R093877 i n h e a l t h y v o l u n t e e r s . (Abstract# G3129) R Hagger, M Benson, R Lloyd, A Britten, M Masoomi, G Gaines, K Antonelli, A Joseph and D Kumar. London, United Kingdom Colonic f e r m e n t a t i o n of lactnlose p r o d u c e s a t o n i c c o n t r a c t i o n i n the h u m a n colon. (Abstract# G3186) P JouSt, C Gorbatchef, B Flouri~, B Coffin, M L~mann, C Franchisseur, R Jian and J-C Rambaud. Paris, France S c i n t i g r a p h i c s t u d y of colonic t r a n s i t after e a t i n g i n p a t i e n t s w i t h f u n c t i o n a l d i a r r h e a . (Abstract# G3053) E Cuillerier, M L~mann, B Coffin, B Flouri~, C Cellier, D Gambini, P JouSt, JP Barbier, JD Rain, JC Rambaud and R Jian. Paris, France Electrophysiological, morphological a n d n l t r a s t r u c t u r a l changes i n u l c e r a t i v e colitis a n d idiopathic c o n s t i p a t i o n . (Abstract# G3276) G Lu, JM Vanderwinden, JJ Rumessen, GL Telford and SK Sarna. Milwaukee, WI; Brussels, Belgium and Hvidovre, Denmark Double-blind, placebo-controlled, crossover s t u d y e v a l u a t i n g t h e effectiveness of colchicine i n t h e t r e a t m e n t of severe i d i o p a t h i c c o n s t i p a t i o n . (Abstract# G3446) CA Sninsky, GN Verne, JM Gordon, EY Eaker and RH Davis. Gainesville, FL and Charleston, SC C o m p a r i s o n of n e o s t i g m i n e a n d b e t h a n e c h o l effects on colonic a n d rectal m o t o r activity, c o m p l i a n c e a n d s e n s a t i o n i n h e a l t h y volunteers. (Abstract# G3232) N-M Law, AE Bharucha and AR Zinsmeister. Rochester, MN Phasic rectal d i s t e n t i o n i n d u c e s colonic r e l a x a t i o n i n h u m a n s . (Abstract# G3233) N-M Law and AE Bharucha. Rochester, MN

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Effects of a c u t e stress o n colonic m o t o r a c t i v i t y a n d a u t o n o m i c a r o u s a l i n p a t i e n t s w i t h constipation. (Abstract# G3385) S Rao, J Leistikow, K Ackerson and J Suls. Iowa City, IA Colonic m o t o r p a t t e r n s i n h e a l t h y h u m a n s - a 24 h o u r a m b u l a t o r y study. (Abstract# G3384) S Rao, J Leistikow, K Ackerson, R Hatfield, K Welcher and M Chamberlain. Iowa City, IA Effects of s h o r t - c h a i n f a t t y acids o n the p h a s i c a n d t o n i c m o t o r a c t i v i t y i n t h e u n p r e p a r e d colon of h e a l t h y h u m a n s . (Abstract# G3119) C Gorbatchef, P JouSt, B Coffin, B Flourid, M Ldmann, C Franchisseur, R Jian and J-C Rambaud. Paris, France I n f l u e n c e of m e n t a l stress a n d r e c t a l d i s t e n s i o n o n t o n i c a n d p h a s i c m o t o r a c t i v i t y of the left colon. (Abstract# G3330) MG Naumann, S Schneider, U Scholz, U Frankenberger, B Wiedenmann and M Karaus. Berlin, Germany

- - T U E S D A Y , M A Y 19, 1 9 9 8 T h i r d degree obstetric p e r i n e a l r u p t u r e : long t e r m clinical a n d f u n c t i o n a l r e s u l t s after r e p a i r . (Abstract# G3377) AC Poen, RJF Felt-Bersma, RLM Strijers, GA Dekker, W Devilld, MA Cuesta and SGM Meuwissen. Amsterdam, The Netherlands Assessment of rectal m e c h a n o r e c e p t o r s i n h e a l t h y h u m a n s b y a reflexologic t e c h n i q u e . (Abstract# G3404) JM Sabatd, D Bouhassira, B Coffin, D Lebars, JC Willer and R Jian. Paris, France Benzocaine does n o t a l t e r r e c t a l sensitivity. (Abstract# G3414) R Sch~fer, A Braun, J Krause, P Enck and JF Erckenbrecht. Duesseldorf, Germany Rectal p r o l a p s e a n d solitary r e c t a l u l c e r s y n d r o m e : clinical a n d pathologic c o r r e l a t i o n s i n 39 p a t i e n t s . (Abstract# G3505) P Velio and MT Bardella. Milan, Italy

A simplified a p p r o a c h to assess p r o x i m a l colonic e m p t y i n g i n h u m a n s . (Abstract# G3045) B C0ulie, EP Bouras, AR Zinsmeister, DD Burton and MM Camilleri. Rochester, MN

Anorectal f u n c t i o n i n a s y m p t o m a t i c p a t i e n t s w i t h t e t h e r e d s p i n a l cord. Effects of surgery. (Abstract# G3315) C Morera and S Nurk0. Boston, MA

MOTILITY AND N E R V E - G U T INTERACTIONS - ANORECTAL MOTILITY: CLINICAL SCIENCE

Influence of sacral roots o n a n o r e c t a l f u n c t i o n . A s t u d y of p a t i e n t s w i t h isolated sacral agenesis. (Abstract# G3316) C Morera and S Nurko. Boston, MA

I n f l u e n c e of t h e 5-HTIA a g o n i s t b u s p i r o n e o n rectal t o n e a n d o n t h e p e r c e p t i o n of rectal d i s t e n s i o n i n man. (Abstract# G3046) B C0ulie, J Tack, R Vos and J Janssens. Leuven, Belgium Is occult s p h i n c t e r defect the cause of a n a l i n c o n t i n e n c e after v a g i n a l delivery? (Abstract# G2940) L Abramowitz, I Sobhani, T Ganansia, A Vuagnat, E Darai, J Benifla, P Madelenat and M Mignon. Paris, France Safety a n d efficacy of d y n a m i c muscle p l a s t y for a n a l i n c o n t i n e n c e : lessons from a prospective, m u l t i c e n t e r trial. (Abstract# G3278) RD Madoff, HR Rosen, CGMI Baeten, LJ LaFontaine, E Cavina, M Devesa, P Rouanet, J Christiansen, JL Faucheron, W Isbister, L Koehler, P Guelinckx and L Puhlman. St Paul, MN P r o s p e c t i v e c o m p a r i s o n of e n d o s o n o g r a p h y a n d d e f e c o g r a p h y i n t h e diagnosis of a n o r e c t a l d y n a m i c d i s o r d e r s a n d p e r i n e a l insufficiency. (Abstract# G2971) M Barthet, D Houtin, F Pottier, M Bouvier, P Mambrini, M Picon, J Salducci and JC Grimaud. Marseille, France Anal s p h i n c t e r m o r p h o l o g y revisited: a c o m p a r i s o n of e n d o s o n o g r a p h i c a n d a n a t o m i c findings. (Abstract# G3085) VF Eckardt, O Dzemali, A Gaumann and MA Konerding. Wiesbaden and Mainz, Germany A p r o s p e c t i v e clinical, physiological a n d radiological s t u d y of a n e w p u r p o s e - d e s i g n e d artificial bowel s p h i n c t e r . (Abstract# G3489) CJ Vaizey, MA Kamm, DM G01d, CI Bartram, S Halligan and RJ Nicholls. London, United Kingdom A n o r e c t a l f u n c t i o n i n C r o h n ' s disease. (Abstract# G3485) J Tsiaoussis, N Karyotakis, E Epanomeritakis, E Chrysos, G Tzovaras, JS Vassilakis and E Xyn0s. Crete, Greece

Anal seepage: s p h i n c t e r d y s f u n c t i o n or i n c o m p l e t e e v a c u a t i o n ? (Abstract# G3383) S Rao, J Kempf and M Stessman. Iowa City, IA D e s c e n d i n g p e r i n e u m s y n d r o m e : clinical a n d l a b o r a t o r y f e a t u r e s a n d o u t c o m e of pelvic floor r e t r a i n i n g . (Abstract# G3138) G Harewood, B C0ulie, D Rath, JH Pembert0n and M Camitleri. Rochester, MN Anorectal physiology c a n p r e d i c t fecal c o n t i n e n c e i n y o u n g c h i l d r e n with o p e r a t e d a n o r e c t a l m a l f o r m a t i o n s . (Abstract# G3293) P Maxwell, R Hagger, J Bland, K Holmes and D Kumar. London, United Kingdom Is t h e r e a n y d i f f e r e n c e o f a n o r e c t a l f u n c t i o n a c c o r d i n g to the p a t t e r n of colon t r a n s i t i n the p a t i e n t s w i t h c h r o n i c i d i o p a t h i c c o n s t i p a t i o n ? (Abstract# G3237) KJ Lee, JM Kim, JH Kim, KB Hahm and SW Cho. Suwon, Korea MOTILITY AND NERVE-GUT I N T E R A C T I O N S - ANORECTAL MOTILITY: BASIC SCIENCE

DDW Poster of Distinction: Role of e n d o t h e l i n s i n the i n t e r n a l a n a l s p h i n c t e r . (Abstract# G3388) S Rattan and S Chakder. Philadelphia, PA Differences i n c o n t r a c t i l e p r o p e r t i e s of a n o r e c t a l smooth m u s c l e m a y p e r m i t t a r g e t e d p h a r m a c o l o g i c a l m a n i p u l a t i o n . (Abstract# G3042) TA Cook, AF Brading and NJMcC Mortensen. Oxford, United Kingdom Heme-oxygenase 2 d i s t r i b u t i o n i n a n o r e c t u m of opossum: colocalization w i t h n e u r o n a l n i t r i c oxide s y n t h a s e a n d vasoactive i n t e s t i n a l polypeptide. (Abstract# G2974) R Battish, GY Cao, RB Lynn, S Chakder and S Rattan. Philadelphia, PA

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GASTROENTEROLOGYVol.114~No.4 II 19, 1998 II

II Heme oxygenase i n h i b i t o r Zn p r o t o p o r h y r i n IX blocks the actions of vasoactive i n t e s t i n a l p o l y p e p t i d e by i n h i b i t i n g G-protein-coupled r e c e p t o r b i n d i n g . (Abstract# G3096) Y Fan, S Chakder and S Rattan. Philadelphia, PA GROWTH, D E V E L O P M E N T , N U T R I T I O N - MUCOSAL GROWTH FACTORS

DDW Poster of Distinction: G a s t r i n i n d u c e s h e p a r i n - b i n d i n g EGF-like growth factor i n r a t g a s t r i c e p i t h e l i a l cells t r a n s f e c t e d with g a s t r i n receptor. (Abstract# G3672) Y Miyazaki, Y Shinomura, S Tsutsui, S Zushi, Y Higashimoto, S Kanayama, S Higashiyama, N Taniguchi and Y Matsuzawa. Osaka, Japan

DDW Poster of Distinction: GLP-2 a u g m e n t s the a d a p t i v e r e s p o n s e to massive i n t e s t i n a l r e s e c t i o n i n t h e rat. (Abstract# G3722) RB Scott, D Kirk, WK MacNaughton and JB Meddings. Calgary, Canada E - c a d h e r i n m e d i a t e d cell-cell c o n t a c t s m o d u l a t e e p i d e r m a l g r o w t h factor i n t r a c e l l u l a r s i g n a l i n g p a t h w a y s . (Abstract# G3734) TG The', A Saunders and JF Thompson. Miami, FL Vascular e n d o t h e l i a l g r o w t h factor e n h a n c e s i n t e s t i n a l e p i t h e l i a l b a r r i e r f o r m a t i o n : p o t e n t i a l role for i n t r a c e l l u l a r cyclic-AMP. (Abstract# G3732) CT Taylor and SP Colgan. Boston, MA P e p s i n o g e n C gene p r o d u c t is a possible growth factor d u r i n g gastric m u c o s a l healing. (Abstract# G3642) K Kishi, Y Kinoshita, Y Matsushima, A Okada, T Maekawa, C Kawanami, N Watanabe and T Chiba. Kyoto and Shimane, Japan U p r e g u l a t i o n of h e p a r i n b i n d i n g - E G F a n d a m p h i r e g u l i n e x p r e s s i o n a n d i n h i b i t i o n of t h e i r p r o l i f e r a t i v e effect o n gastric m u c o s a l cells by Itelicobacterpylor] recognize s e p a r a t e m e c h a n i s m s . (Abstract# G3715) M Romano, V Ricci, P Sommi, C Del Vecchi0 Blanco, CB Bruni and R Zarrilli. Naples and Pavia, Italy

EGF r e c e p t o r l i g a n d s a n d polyamines: n e w i n s i g h t s i n growth control i n colon c a n c e r cells. (Abstract# G3552) R Bauske, V Milovic, WF Caspary and J Stein. Frankfurt, Germany E G F - s t i m u l a t e d p u t r e s c i n e u p t a k e i n CaCo-2 cells is associated w i t h s t r u c t u r a l changes of t h e a p i c a l m e m b r a n e . (Abstract# G3670) V Milovic, R Bauske, C von Sch6ppenthau, WF Caspary and J Stein. Frankfurt, Germany Antizyme mRNA d i s t r i b u t i o n a l o n g the crypt/villus axis a n d m o d u l a t i o n of e x p r e s s i o n i n r e s p o n s e to polyamines. (Abstract# G3608) J Gill, L Kirby and ER Seidel. Greenville, NC Myc a n d Max disassociate following p o l y a m i n e d e p l e t i o n i n small i n t e s t i n a l crypt cells. (Abstract# G3654) J Li, L Li, JN Rao, BL Bass and J-Y Wang. Baltimore, MD I d e n t i f i c a t i o n of n e r v e g r o w t h factor p r o h o r m o n e isoforms i n gastric j u i c e of rats. (Abstract# G3597) BEgger, M Reinshagen, I Geerling, K Huff, SR Vijaya, J Lakshmanan and VE Eysselein. Torrance, CA; Bern, Switzerland and Ulm, Germany G M - C S F regulates e x p r e s s i o n of a n o v e l colonic

epithelial p r o t e i n r e c o g n i z e d b y 7E12H12 m o n o c l o n a l antibody. (Abstract# G3684) A Panja and KM Das. New York, NY and New Brunswick, NJ K e r a t i n o c y t e growth factor e n h a n c e s e a r l y r e g r o w t h i n a r a t model of s h o r t bowel syndrome. (Abstract# G3631) WF Johnson, CR DiPalma, TR Ziegler and CL Farrell. Thousand Oaks, CA and Atlanta, GA Surface h y d r o p h o b i c i t y of the h u m a n mucosa: role of e p i d e r m a l growth factor. (Abstract# G3659) A Lugea, F Guarner, JR Malagelada, JL S~nchez, F Lara and M Armengol. Barcelona, Spain GROWTH, DEVELOPMENT, N U T R I T I O N - GASTROINTESTINAL DEVELOPMENT: CELLULAR AND MOLECULAR BIOLOGY

DDW Poster of Distinction:

E x p r e s s i o n a n d l o c a l i z a t i o n of ErbB4 a n d its ligand, n e u r e g u l i n , i n h u m a n g a s t r o i n t e s t i n a l mucosa. (Abstract# G3639) H Kataoka, T Joh, K Tsuchida, K Seno, Y Yokoyama, T Kato and M Itoh. Nagoya, Japan

U n c o u p l i n g of morphological a n d e n d o c r i n e

The t a r g e t e d d i s r u p t i o n of t h e g a s t r i n gene i n mice r e s u l t s i n decreased p r o l i f e r a t i o n of t h e stomach a n d colon i n r e s p o n s e to refeeding. (Abstract# G3644) TJ Koh, GJ Dockray, A Varro, D Chen and TC Wang. Boston, MA; Liverpool, United Kingdom and Lund, Sweden

C h a r a c t e r i z a t i o n of h u m a n b r u s h b o r d e r m y o s i n I c D N A a n d basal l o c a l i z a t i o n of its mRNA i n j e j u n a l enterocytes. (Abstract# G3655) W Li, P Matsudaira, LM Coluccio and RJ Grand. Boston, MA

R e t i n o i c acid i n d u c e s d i f f e r e n t i a t i o n a n d the e x p r e s s i o n of i n s u l i n - l i k e b i n d i n g protein-7 i n h u m a n gastric c a n c e r cells. (Abstract# G3548) KD Bacon, MJ Rutten, DL Graham, J Engstr0m, BC Sheppard, RA Crass, KE Deveney, DD Trunkey, EM Wilson, V Hwa, Y Oh, RG Rosenfeld and CW Deveney. Portland, OR

Morphogenesis of a complete h u m a n i n t e s t i n a l u n i t from single xenografted colonic crypts. (Abstract# G3581) R Del Buon0, NA Wright and CJ Hawkey. Nottingham and London, United Kingdom

E p i d e r m a l g r o w t h factor s t i m u l a t e s p r o t e i n k i n a s e C e i n a n i n t e s t i n a l e p i t h e l i a l cell line. (Abstract# G3700) DB Polk, MR Frey and JD Black. Nashville, TN and Buffalo, NY

differentiation in the rat intestine during

organogenesis. (Abstract# G3708) C Ratineau, I Duluc, J Dumortier, JA Chayvialle, M Kedinger and C Roche. Lyon and Strasbourg, France

T r a n s f o r m i n g g r o w t h factor-~l d o w n r e g u l a t e s r a b l l expression i n d i f f e r e n t i a t i n g T84 i n t e s t i n a l epithelial cells. (Abstract# G3657) K Lindfors, T Halttunen, H Kainulainen and M M~iki. Tampere, Finland

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E12 e m b r y o n i c m o u s e i n t e s t i n e s show a p p r o p r i a t e s p a t i o t e m p o r a l d e v e l o p m e n t a l p a t t e r n s i n a serumless, chemically-defined in vitro o r g a n c u l t u r e system. (Abstract# G3591) G Duh, D Thomas and D Warburt0n. Los Angeles, CA

I n t e g r i n s u b u n i t a c t i v a t i o n m o d u l a t e s h u m a n colonic epithelial p r o l i f e r a t i o n a n d d i f f e r e n t i a t i o n o n a l a m i n i n matrix. (Abstract# G3598) NJ Emenaker and MD Bass0n. New Haven and West Haven, CT

H o r m o n a l a n d d i e t a r y c o n t r o l of ontogenic expression of ileal bile acid b i n d i n g p r o t e i n . (Abstract# G3621) ST Hwang and SJ Henning. Houston, TX

R e g u l a t i o n of h u m a n gastric lipase expression i n o r g a n c u l t u r e b y e p i d e r m a l g r o w t h factor. (Abstract# G3668) D Mdnard and E Tremblay. Sherbr0oke, Canada

The a c t i n b u n d l i n g p r o t e i n fascin, influences epithelial cell morphology, s p r e a d i n g a n d m i g r a t i o n . (Abstract# G3627) AU Jawhari, M Noda, J Adams, MJG Farthing and M Pignatelli. London, United Kingdom

G e n e r a t i o n of p r i m a r y c u l t u r e s of epithelial cells from h u m a n fetal stomach. (Abstract# G3568) P Chailler, JR Basque, N Perreault, JF Beaulieu and D M~nard. Sherbrooke, Canada

C l o n i n g of r a t t r e h a l a s e cDNA a n d studies of the i n f l u e n c e of glucocorticoids o n the ontogenic e x p r e s s i o n of t r e h a l a s e mRNA i n the small intestine. (Abstract# G3682) TJ Oesterreicher, NN Nanthakumar, JH Winston and SJ Henning. Houston, TX Molecular c l o n i n g a n d c h a r a c t e r i z a t i o n of the r a t NHE2 p r o m o t e r . (Abstract# G3572) JF Collins, YL Muller, L Bai, H Xu and FK Ghishan. Tucson, AZ E n t e r o c y t i c d i f f e r e n t i a t i o n of the CaCo-2 cell line is associated w i t h i n c r e a s e s i n AP-1 b i n d i n g activity. (Abstract# G3585) Q-m Ding, Z Dong and BM Evers. Galveston, TX I n h i b i t i o n of m i t o g e n - a c t i v a t i o n p r o t e i n k i n a s e m a y be r e q u i r e d for CaCo-2 cell differentiation. (Abstract# G3586) Q-m Ding and BM Evers. Galveston, TX Cdx-2 activates t r a n s c r i p t i o n of the lactase p r o m o t e r t h r o u g h i n t e r a c t i o n w i t h the A/T-rich region of rCELPH1. (Abstract# G3602) R Fang and E Sibley. Stanford, CA

Venous d e v e l o p m e n t of e m b r y o n i c gut c a n be followed u p by m u c o s a l address i n cell a d h e s i o n molecule-1. (Abstract# G3617) H Hashi, H Yoshida, H Kubo, Y Sakai, A Takabayashi, SI Nishikawa and Y Yamaoka. Kyoto, Japan P o s t n a t a l d e v e l o p m e n t of i n t e r s t i t i a l cells of Cajal Kit i m m u n o r e a c t i v i t y studies b y confocal microscopy on w h o l e m o u n t s of mouse i n t e s t i n e a n d colon. (Abstract# G3740) J-M Vanderwinden, K Gillard and J-J Vanderhaeghen. Brusselles, Belgium E s t a b l i s h m e n t a n d c u l t u r e of s t o m a c h a n t r u m isolated from k i t t e n a n d cat gastric a n t r a l s m o o t h muscle cells. (Abstract# G3667) LJ Melkerson-Watson, AC Hillemeier and KN Bitar. Ann Arbor, MI Expression of e x t r a c e l l u l a r m a t r i x p r o t e i n s i n fetal r a t stomachs. (Abstract# G3736) K Tcmmer~s, JL Cabero and S M~rdh. Link6ping and M61ndal, Sweden The endosomal a n d lysosomal c o m p a r t m e n t s i n fetal h u m a n small i n t e s t i n a l e n t e r o c y t e s . (Abstract# G3737) JF Trahair. Adelaide, Australia

Lactase p r o x i m a l p r o m o t e r cis-element activates t r a n s c r i p t i o n a n d i n t e r a c t s w i t h two distinct n u c l e a r p r o t e i n s . (Abstract# G3603) R Fang and E Sibley. Stanford, CA

Heterogeneous d i s t r i b u t i o n of digestive enzymes i n r a t p a n c r e a s is h i g h l y i n f l u e n c e d b y diet. (Abstract# G3575) JA Coutu and JW Adelson. Providence, RI

Role of cyclins, c y c l i n - d e p e n d e n t k i n a s e a n d cyclind e p e n d e n t k i n a s e i n h i b i t o r s i n d i f f e r e n t i a t i o n of the h u m a n i n t e s t i n a l e p i t h e l i a l cell l i n e tsFHI. (Abstract# G3735) J Tian and A Quaroni. Ithaca, NY

GROWTH, DEVELOPMENT, N U T R I T I O N PEDIATRIC AND G A S T R O I N T E S T I N A L LIVER DISEASE

E x p r e s s i o n of the i n t e g r i n a9~1 i n the e p i t h e l i u m of the d e v e l o p i n g h u m a n gut a n d i n i n t e s t i n a l cell lines: r e l a t i o n w i t h cell p r o l i f e r a t i o n . (Abstract# G3550) N Basora, N Desloges, N Perreault, Y B0uatrouss, D Sheppard and J-F Beaulieu. Sherbr00ke, Canada and San Francisco, CA U p s t r e a m s t i m u l a t o r y factor b i n d s to a consensus Ebox i n t h e p r o m o t e r of t h e h u m a n dipeptidyl peptidase IV gene. (Abstract# G3600) RH Erickson, CD Lotterman and YS Kim. San Francisco, CA P r o d u c t i o n of p r i m a r y c u l t u r e s of fully differentiated a n d p u r e h u m a n enterocytes. (Abstract# G3691) N Perreault and J-F Beaulieu. Sherbr00ke, Canada I n t e s t i n a l a r g i n i n e b i o s y n t h e s i s is crucial for m a i n t a i n i n g a r g i n i n e s e r u m levels i n sucklings. (Abstract# G3580) WJ de J0nge, MA Van R00n and WH Lamers. Amsterdam, The Netherlands

DDW Poster of Distinction: A s t u d y of p a n c r e a t i c f u n c t i o n i n 17 c h i l d r e n w i t h Alagille syndrome. (Abstract# G3630) HA John, K Loomes, R Weyler, V Stallings, DA Piccoli and AE Mulberg. Philadelphia, PA

DDW Poster of Distinction: C o u n t e r r e g u l a t o r y h o r m o n e s i n c h i l d r e n with hypoglycemia caused b y d u m p i n g syndrome. (Abstract# G3557) J B0rov0y, JI Wolfsd0rf and S Nurko. Boston, MA Neonatal r e n a l insufficiency a n d r e n a l acidosis are m a n i f e s t a t i o n s of Alagille s y n d r o m e i n infancy. (Abstract# G3664) KE McBride and DA Piccoli. Philadelphia, PA Prospective e v a l u a t i o n of t h e p r e d i c t i v e v a l u e of serological s c r e e n i n g tests i n p e d i a t r i c i n f l a m m a t o r y bowel disease. (Abstract# G3588) M Dubinsky, F Ruemmele, S Targan, J Braun and E Seidman. Montreal, Canada and Los Angeles, CA

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AGAPOSTERNENSION--TUENDAY,

Non-invasive a s s e s s m e n t of f o r e g u t m o t i l i t y i n v o m i t i n g c h i l d r e n w i t h d i s o r d e r s of t h e c e n t r a l n e r v o u s system. (Abstract# G3709) AM Ravelli and PJ Milla. Brescia, Italy and London, United Kingdom I n f l a m m a t o r y m e d i a t o r s are t h e m a j o r d e t e r m i n a n t of delayed p u b e r t y a s s o c i a t e d w i t h i n t e s t i n a l i n f l a m m a t i o n . (Abstract# G3547) O Azooz, AB Ballinger and MJG Farthing. London, United Kingdom L i n e a r g r o w t h f a i l u r e a n d d i s t u r b a n c e s of the GH-IGF axis i n p a t i e n t s w i t h b i l i a r y atresia. (Abstract# G3570) E Chuang, A Tershakovec and BA Haber. Philadelphia, PA Cost-effectiveness of n o n - i n v a s i v e s c r e e n i n g for H.

pylori i n dyspeptic c h i l d r e n r e f e r r e d for endoscopy. (Abstract# G3705) T Puetz, J Heikenen, S Werlin and N Vakil. Milwaukee, WI Epigastric abdominal pain in children: combined e m p i r i c t r e a t m e n t a n d specific H. pylori s c r e e n i n g a n d t r e a t m e n t decrease cost of e v a l u a t i o n . (Abstract# G3683) AD Olson and D Deutsch. Ann Arbor, MI and Rockford, IL R a p i d office-based serology is n o t useful i n p r e d i c t i n g active H. pyloriinfection i n p e d i a t r i c patients. (Abstract# G3658) KN Liquornik, CA Liacouras, ED Ruchelli and DC Metz. Philadelphia, PA L u m b a r s p i n e bone m i n e r a l d e n s i t y i n c h i l d r e n with cystic fibrosis. (Abstract# G3739) R Ujhelyi, M Szathm~ri, MI~ Horv~ith, K Holics, A SzabS, M T6th, T Tulassay and Z Tulassay. Budapest, Hungary

MAY

19, 1 9 9 8

C h i l d r e n w i t h h y p e r m o b i l e j o i n t s : are they a t r i s k for rectal prolapse and/or c o n s t i p a t i o n . (Abstract# G3614) TS Gunasekaran, P Roy, J Kless, C Spencer and J Berman. Park Ridge and Chicago, IL Omeprazole: t h e r a p y of choice i n i n s t i t u t i o n a l i z e d i n t e l l e c t u a l l y d i s a b l e d children. (Abstract# G3556) CJM B~hmer, MC Niezen-de-Boer, EC Klinkenberg-Knol and SGM Meuwissen. Amsterdam and Zeist, The Netherlands GROWTH, DEVELOPMENT, N U T R I T I O N - - AGING I m m u n o s e n e s c e n c e of the G! i m m u n e system: i n c r e a s e d secretion of p r o i n f i a m m a t o r y cytokines b y LPMNC. (Abstract# G3679) S Nikolaus, A Raedler and S Schreiber. Hamburg, Germany Levels of apical Na ÷ c h a n n e l a n d b a s o l a t e r a l Na÷,K÷ATPase p r o t e i n s i n h u m a n distal colon do n o t c h a n g e with age. (Abstract# G3611) ER Greig, RP Boot-Handford and GI Sandle. Salford and Manchester, United Kingdom Age-associated decrease i n n i t r i c oxide-induced i o n t r a n s p o r t i n m u r i n e small i n t e s t i n e . (Abstract# G3710) RR Reddix. New Orleans, LA N e u r o n a l n i t r i c oxide s y n t h a s e e x p r e s s i o n declines w i t h age i n m u r i n e small i n t e s t i n e . (Abstract# G3701) AR Powell and RR Reddix. New Orleans, LA B o m b e s i n - i n d u c e d p a n c r e a t i c r e g e n e r a t i o n i n r a t s is age-dependent. (Abstract# G3587) E Distrutti, S Fiorucci, A Bufalari, M Pensi, S Caporali, B Federici, L Moggi and A Morelli. Perugia, Italy

Crohn's disease: i n f l u e n c e of age at o n s e t on clinical p h e n o t y p e . (Abstract# G3577) C Cuffari and TM Bayless. Baltimore, MD

IMMUNOLOGY, MICROBIOLOGY, AND INFLAMMATORY DISORDERS - - IBD: ANIMAL MODELS AND PRECLINICAL T R E A T M E N T

L o n g i t u d i n a l c h a n g e s i n l i v e r enzymes a n d growth s t a t u s i n c h i l d r e n w i t h cystic fibrosis. (Abstract# G3663) MR Mascarenhas, BS Zemel, ES Mailer, TF Scanlin and VA Stallings. Philadelphia, PA

Selective i n h i b i t i o n of p h o s p h o d i e s t e r a s e type IV ameliorates c h r o n i c colitis a n d p r e v e n t s i n t e s t i n a l fibrosis. (Abstract# G4542) S Videla, J Vilaseca, G Gonzalez, A Salas, M Antolin, M Mourelle, F Guarner and J-R Malagelada. Barcelona and Terrassa, Spain

P r o p o s e d l i n k b e t w e e n Helicobacterpylori a n d s u d d e n i n f a n t d e a t h s y n d r o m e : possible p a t h o g e n i c m e c h a n i s m s i n a n a n i m a l model. I. Effects of i n t r a t r a c h e a l urease. (Abstract# G3689) CP Pattison, BJ Marshall, LW Scott, B Herndon and SK Willsie. Kansas City, MO P r e v a l e n c e of Itelicobacterpyloriin s u d d e n i n f a n t d e a t h syndrome. (Abstract# G3688) CP Pattison, GG Vergara, TW Young and GP Smith. Kansas City, MO Anorectal m a n o m e t r i c e x a m i n a t i o n does n o t p r e d i c t r e s p o n s e to t h e r a p y for r e t e n t i v e or n o n - r e t e n t i v e e n c o p r e t i c - c o n s t i p a t e d c h i l d r e n . (Abstract# G3728) J Sutphen, S Borowitz, D Cox, B Kovatchev and J Morris. Charlottesville, VA Portosystemic shunting in children with portal h y p e r t e n s i o n - its role i n the era of endoscopic therapy. (Abstract# G3640) T Kato, R Romero, R Koutouby, J Thompson, CL Schleien and AG Tzakis. Miami, FL E v a l u a t i o n of r e d u c e d o s m o l a r i t y oral r e h y d r a t i o n s o l u t i o n i n c h i l d r e n w i t h severe p e r s i s t e n t diarrhea: a r a n d o m i z e d d o u b l e - b l i n d c o n t r o l trial. (Abstract# G3716) SA Sarker, NH Alam and GJ Fuchs. Dhaka, Bangladesh

DDW Poster of Distinction: Dietary i n u l i n p r e v e n t s distal colitis i n d u c e d b y d e x t r a n sulfate sodium. (Abstract# G4541) S Videla, J Vilaseca, A Garc~a-Lafuente, M Antol~n, E Crespo, F Guarner, JR Malagelada, J Casalots and A Salas. Barcelona and Terrassa, Spain

DDW Poster of Distinction: L y m p h o t o x i n b e t a r e c e p t o r - i m m u n o g l o b u l i nf u s i o n p r o t e i n a m e l i o r a t e s i n f l a m m a t i o n a n d t i s s u e damage i n the d e x t r a n sulfate model of m o u s e colitis. (Abstract#

G4282) S Murthy, A Flanigan, K Tanaka, H Yoshitake and B Osborne. Philadelphia, PA and Cambridge, MA

DDW Poster of Distinction: Mice o v e r e x p r e s s i n g t r a n s f o r m i n g growth factor-~ have a r e d u c e d s u s c e p t i b i l i t y to d e x t r a n s o d i u m sulfatei n d u c e d colitis. (Abstract# G3982) B Egger, HV Carey, F Procaccino, N Chai, EP Sandgren, J Lakshmanan, VS Buslon, SW French and VE Eysselein. Bern, Switzerland; Torrance, CA and Madison, WI

April1998

PROGRAMOF THE ANNUALMEETINGP163

A G A P O S T E R S E S S I O N m T U E S D A Y , M A Y 19, 1 9 9 8 DDW Poster of Distinction: Alterations in epithelial gene expression during e x p e r i m e n t a l colitis. (Abstract# G4373) IB Renes, M Verburg, LA Duits, S Ferdinandusse, HA BOller, AWC Einerhand and J Dekker. Amsterdam and Rotterdam, The Netherlands

DDW Poster of Distinction: O x a z o l o n e - i n d u c e d colitis: a n a n i m a l m o d e l of u l c e r a t i v e colitis t r e a t a b l e w i t h a n t i b o d i e s to IL-4. (Abstract# G4020) IJ Fuss, M Boirivant, AC Chu and W Strober. Bethesda, MD and Rome, Italy

DDW Poster of Distinction: The r o l e of CD8+ T cells f o r d e v e l o p m e n t of colitis in G~i2-deficient mice. (Abstract# G4316) L ()hman, U Rudolph, L Birnbaumer, GR Harriman and E HSrnquist. GSteborg, Sweden and Houston, TX Colitis i n IL-10 g e n e - d e f i c i e n t m i c e is p r e v e n t e d by a n t i b i o t i c t r e a t m e n t d u r i n g t h e n e o n a t a l period. (Abstract# G4215) KL Madsen, JS Doyle, MM Tavernini, LD Jewell, RP Rennie and RN Fedorak. Edmonton, Canada Effect of zinc s u p p l e m e n t a t i o n on i n t e s t i n a l m e t a l l o t h i o n e i n c o n c e n t r a t i o n i n e x p e r i m e n t a l colitis i n rats. (Abstract# G3958) V Di Leo, M Barollo, W Fries, E Mazzon, P Irato, C Mestriner, R D'Inc~ and GC Sturniolo. Padua and Messina, Italy D i f f e r e n t i a l effects of IL-11 on i o n t r a n s p o r t in t h e s m al l i n t e s t i n e a n d colon of HLA-B27 rats. (Abstract# G4048) B Greenwood-Van Meerveld, KR Tyler and J Keith. Oklahoma City, OK and Andover, MA A n t i i n f l a m m a t o r y effects of a n o v e l a n t i o x i d a n t in rats. (Abstract# G4047) B Greenwood-Van Meerveld, KR Tyler, LJ Peters, W Flitter and W Garland. Oklahoma City, OK and Sunnyvale, CA Effect of i r o n on m u c o s a l T h l c y t o k in e s in t h e IL-10 k n o c k o u t mouse. (Abstract# G4318) B Oldenburg, DM Rennick, GP van Berge Henegouwen, BS van Asbeck and JC Koningsberger. Utrecht, The Netherlands and Palo Alto, CA T h e co l o n i c m e s e n t e r i c m a r g i n is most s u s c e p t i b l e to i n j u r y i n a n e x p e r i m e n t a l m o d e l of g a s t r o i n t e s t i n a l v as cu l i t i s . (Abstract# G3776) A Anthony, AP Dhillon, RE Pounder and AJ Wakefield. London, United Kingdom G e n e t i c c o n t r o l of s e c r e t o r y IgA r e s p o n s e s i n mice. (Abstract# G3864) IJ Bristol, K McElwee, JP Sundberg, EH Leiter, Y Cong and CO Elson. Bar Harbor, ME and Birmingham, AL M y c o p h e n o l a t e m o f e t i l r e d u c e s tissue d a m a g e in an e x p e r i m e n t a l m o d e l of colitis in rats. (Abstract# G4594) JM Zeeh, I Zorlu, NE Riley, H Goebell and AU Dignass. Essen, Germany Soluble r e c o m b i n a n t h u m a n P-selectin g l y c o p r o t e i n ligand-1 d e c r e a s e s i n t e s t i n a l lesions in HLA-B27 t r a n s g e n i c r a t s a n d i n acetic a c i d i n d u c e d colitis in S p r a g u e - D a w l e y rats. (Abstract# G3765) LM Albert, U Patel, TJ Ferranti, A Ahmed, RG Schaub and JC Keith, Jr. Cambridge, MA

Anti-interleukin-6 r e c e p t o r mAb p r e v e n t s c h r o n i c i n t e s t i n a l i n f l a m m a t i o n in SCID m i c e r e c o n s t i t u t e d w i t h CD4+ CD45RBhigh T cells. (Abstract# G4576) M Yamamoto, H Ito, S Kanazawa, H Ogawa, H Nakamura and T Kishim0to. Osaka, Japan E x p e r i m e n t a l colitis in n u / n u m i c e i n d u c e d by t h e t r a n s f e r of l y m p h o c y t e s f r o m s y n g e n e i c m i c e i n f e c t e d w i t h a m u r i n e r e t r o v i r u s : a n a l y s e s of t h e d i s t r i b u t i o n of t h e i n f l a m m a t o r y cells in situ. (Abstract# G4483) K Suzuki, H Suriki, Y Baba, K Hasegawa, T Mochizuki, Y Satoh, K Sugimura, T Homma, R Narisawa, H Kanazawa, H Kawachi, F Shimizu and H Asakura. Niigata, Japan L o c a l i z a t i o n of t i s s u e k a l l i k r e i n in p e p t i d o g l y c a n i n d u c e d e n t e r o c o l i t i s in Lewis r a t : f u r t h e r e v i d e n c e for secretion. (Abstract# G4461) A Stadnicki, I Stadnicka, RW Colman, J Chao, K-F Lin, E van Tol, F Li and RB Sartor. Philadelphia, PA; Charleston, SC; Chapel Hill, NC C o n t i n u o u s f e e d i n g of Lactobacillus plantarum a t t e n u a t e s e s t a b l i s h e d colitis i n interleukin-10deficient mice. (Abstract# G4426) M Schultz, C Veltkamp, LA Dieleman, PB Wyrick, SL Tonkonogy and RB Sartor. Chapel Hill and Raleigh, NC I m m u n o l o g i c a l e v e n t s in d e x t r a n sulfate s odi umi n d u c e d colitis in rats: a m o r p h o l o g i c a l , i m m u n o h i s t o c h e m i c a l a n d u l t r a s t r u c t u r a l study. (Abstract# G4181) FW Leung, MCY Heng, S Allen, K Seno, K Lam, JWC Leung and MK Heng. Los Angeles and Sacramento, CA Efficacy of anti-TNF in c o m p a r i s o n w i t h m e t r o n i d a z o l e in t h e i n d o m e t h a c i n - i n d u c e d s m a l l b o w el i n f l a m m a t i o n model. (Abstract# G3910) S Colpaert, Z Liu, B Degreef, G D'Haens, K Geboes, J Ceuppens and P Rutgeerts. Leuven, Belgium P r o t e c t i v e r o l e of c a l c i t o n i n g e n e - r e l a t e d p e p t i d e on acu t e a n d c h r o n i c gut i n f l a m m a t i o n in rats. (Abstract# G4239) L Mazelin, V Theodorou, J Fioramonti and L Bu~no. Toulouse, France A d o p t i v e l y t r a n s f e r r e d T l y m p h o c y t e s of m i c e i n f e c t e d with a murine retrovirus induce proctitis in syngeneic n u / n u mice. (Abstract# G4478) H Suriki, K Suzuki, Y Baba, K Hasegawa, T Mochizuki, Y Satoh, K Sugimura, T Honma, R Narisawa, H Kanazawa, H Kawachi, F Shimizu and H Asakura. Niigata, Japan H o m i n g a n d cell a d h e s i o n r e c e p t o r s i n v o l v e d i n e x p e r i m e n t a l colitis. (Abstract# G3874) L Camoglio, AA te Velde, JB Daalhuisen and SHJ van Deventer. Amsterdam, The Netherlands S u p e r i n f e c t i o n w i t h ttelicobactcr hepaticus does not al t er t h e n a t u r a l c o u r s e of colitis in IL-10-deficient mice. (Abstract# G3927) SJ Czinn, BM Zag0rski, DM Spencer, C Garhart and AD Levine. Cleveland, OH C o n c o m i t a n t interleukin-10 t h e r a p y m i n i m i z e s r e a c t i v a t i o n of c o r t i e o s t e r o i d - t r e a t e d c h r o n i c g r a n u l o m a t o u s i n t e s t i n a l a n d s y s t e m i c i n f l a m m a t i o n in rats. (Abstract# G4183) F Li, S Saundres and RB Sartor. Chapel Hill, NC Focal v e r s u s diffuse colitis: l o c a l i z a t i o n of lesions in CD4+T c e l l - m e d i a t e d e x p e r i m e n t a l IBD. (Abstract# G3912) Y Cong, CT Weaver, A Lazenby, JP Sundberg and CO Els0n. Birmingham, AL and Bar Habor, ME

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AGA POSTER S E S S I O N - - TUESDAY, N A Y 19, 1998 The s u s c e p t i b i l i t y to s t r e s s - i n d u c e d r e a c t i v a t i o n of colitis r e q u i r e s CD4+ve b u t n o t CD8+ve T lymphocytes. (Abstract# G4361) BS Qiu, BA Vallance, PA Blennerhassett and SM Collins. Hamilton, Canada

The trefoil p e p t i d e TFF-2 p o t e n t l y accelerates h e a l i n g i n a r a t model of i n f l a m m a t o r y bowel disease. (Abstract# G4505) CP Tran, GA Cook, G Maryatt, LM Parker, L Thim, ND Ye0mans and AS Giraud. Melbourne, Australia and Denmark

I m p a i r e d e n t e r i c n e u r a l f u n c t i o n d u r i n g T. spir~zlis i n f e c t i o n i n mice is m a c r o p h a g e d e p e n d e n t . (Abstract# G4022) F Galeazzi, EM Haapala, N Van R00ijen, BA Vallance and SM Collins. Hamilton, Canada and Amsterdam, The Netherlands

The specific type IV p h o s p h o d i e s t e r a s e i n h i b i t o r r o l i p r a m mitigates e x p e r i m e n t a l colitis i n mice. (Abstract# G3820) C Bidlingmaier, G Hartmann, K Tsch~p, A Eigler, HA Lehr and S Endres. Munich and Mainz, Germany

Macrophages i n f i l t r a t e i n t e s t i n a l muscle layers a n d m y e n t e r i c plexus d u r i n g T. spiralis i n f e c t i o n i n mice. (Abstract# G4023) F Galeazzi, BA Vallance and SM Collins. Hamilton, Canada The earliest h i s t o p a t h o l o g i c c h a n g e s of d e x t r a n sulfate s o d i u m e x p e r i m e n t a l a c u t e colitis. (Abstract# G4437) K Shichijo, M Matsuu, Y Ikeda, S Naito, M Ito and I Sekine. Nagasaki, Japan R a b b i t colonic m u c i n s i n d u c e a u t o a n t i b o d i e s a n d m a y cause u l c e r a t i v e colitis-like m u c o s a l damage. (Abstract# G4315) S Ohara, M Igarashi, S Nakano, T Kubota, F Ogawa and K Hotta. Sagamihara, Japan C u r a t i v e effects of p h o s p h o d i e s t e r a s e 4 i n h i b i t o r s i n d e x t r a n sulfate s o d i u m - i n d u c e d colitis i n t h e rat. (Abstract# G4357) J Puig, C Salcedo, A Salas, AG Fern~indez and JM Palacios~ Barcelona, Spain Gastrointestinal permeability in interleukin-10 k n o c k o u t mice. (Abstract# G4568) J-N Wu, D-M McCafferty, KA Sharkey, RN Fedorak and JB Meddings. Calgary, Canada The effect of v a s c u l a r e n d o t h e l i a l growth factor on e x p e r i m e n t a l u l c e r a t i v e colitis i n rats. (Abstract# G4403) Z Sandor, G Singh and S Szabo. Long Beach and Irvine, CA 5-aminosalicylate r e t e n t i o n i n t h e m u r i n e colonic m u c o s a varies a m o n g cell types. (Abstract# G3784) G Armstrong and MH Montrose. Baltimore, MD G a s t r o i n t e s t i n a l p e r m e a b i l i t y to n o n - s t e r o i d a n t i i n f l a m m a t o r y drugs. A p r o s p e c t i v e s t u d y c o m p a r i n g meloxicam to slow-release i n d o m e t h a c i n . P r e l i m i n a r y results. (Abstract# G4449) E Smecu01, E Sugai, E Maurifio, H Vazquez, S Nivel0ni, S Pedreira, J Meddings and JC Bai. Buenos Aires, Argentina and Calgary, Canada I n h i b i t i o n of i n f l a m m a t i o n a n d a n o r e x i a b y the novel a n t i i n f l a m m a t o r y d r u g d e x a n a b i n o l (HU-211). (Abstract# G4243) KJ McHugh, D Elston, SM Collins and HP Weingarten. Hamilton, Canada N e u r o i m m u n e m e c h a n i s m s i n a r a t model of stressi n d u c e d r e a c t i v a t i o n of e x p e r i m e n t a l colitis. (Abstract# G4254) PC Miceli, BA Vallance and K Jacobson. Hamilton, Canada

T h e r a p e u t i c effect of r e b a m i p i d e a n d 5-aminosalicylic acid o n d e x t r a n sulfate s o d i u m - i n d u c e d r a t colitis: s u p p r e s s i o n of i n f l a m m a t o r y cytokines. (Abstract# G4137) S Kishimoto, K Hayashi and K Sakural. Hiroshima, Japan and R0ckville, MD E n h a n c e m e n t of i n t e s t i n a l epithelial r e p a i r b y a h u m a n glucagon-like peptide-2 analogue, h[Gly2]-GLP-2, i n a m u r i n e model of u l c e r a t i v e colitis. (Abstract# G3968) DJ Drucker, L DeForest, B Yusta and PL Brubaker. Toronto, Canada The effect of NOS i n h i b i t o r s o n TNB colitis - a c o m p a r a t i v e study. (Abstract# G4290) H Nakamura, H Tsukada, M Onomura, T Saito, K Fukuda, M K0dama, M H0sokawa and Y Sein0. Kyoto, Japan L - a r g i n i n e worsens the colonic d a m a g e a n d i n c r e a s e s the collagen c o n t e n t i n e x p e r i m e n t a l colitis b y a m e c h a n i s m i n d e p e n d e n t from n i t r i c oxide. (Abstract# G4224) J Marie, F Fern~ndez-Bariares, E Castell~, R Bartoli, X Bertr~n, M ~dvarez and MA Gassull. Badalona, Spain

In d v o t r e a t m e n t with the f u n g a l m e t a b o l i t e gliotoxin suppresses i n t e s t i n a l i n f l a m m a t i o n i n d e x t r a n s u l p h a t e s o d i u m - i n d u c e d colitis. (Abstract# G4068) H Herfarth, HC Rath, R H0fmeister, G Rogler, K Brand, J Sch61merich and W Falk. Regensburg and Munich, Germany Lesions i n d u c e d i n colon a n d d u o d e n u m b y cysteamine: s a l u t a r y effect of p e n t a d e c a p e p t i d e BPC 157 a n d o t h e r a n t i u l c e r agents. (Abstract# G4441) P Sikirid, S Seiwerth, ~, Grabarevid, R Ru~man, M Petek, S Mige, I Rotkvi~, B Turkovid, V Jagi~, P Konjevoda, J Aralica, N DiBiaggio, M Han~.eva~ki, J Separovi~, D Mikug, G Aralica and L Berkopid. Zagreb, Croatia C o r t i c o t r o p i n - r e l e a s i n g factor r e c e p t o r 2 a g o n i s t a n d CRF 1 r e c e p t o r a n t a g o n i s t decrease p a i n r e s p o n s e to colorectal d i s t e n t i o n i n rats. (Abstract# G4257) M Million, T Nozu, A Gauthier, D Adelson, C Maillot, N Morrow, T Garrick and Y Tachd. Los Angeles, CA C h r o n i c stress-induced w o r s e n i n g of c h r o n i c colonic i n f l a m m a t i o n i n Lewis r a t s involves colonic m a s t cells d e g r a n u l a t i o n . (Abstract# G4256) M Million, A Belai, Y Akiba, AP Anton and Y Tachd. Los Angeles, CA I n d u c t i o n of M cells i n t h e i n d o m e t h a c i n - i n d u c e d ileitis i n r a t s - s t r o n g c o r r e l a t i o n w i t h histological degree of i n f l a m m a t i o n . (Abstract# G4155) T Kucharzik, N Liigering, M Linnepe, K Rautenberg, C Cichon, MA Schmidt, R Stoll and W Domschke. Muenster, Germany

April1998

PROGRAMOF THEANNUALMEETINGP165

A G A P O S T E R S E S S I O N m T U E S D A Y , M A Y 19, 1998 IMMUNOLOGY, MICROBIOLOGY, AND INFLAMMATORY DISORDERS - - IBD: GENETICS Date of b i r t h i n familial C r o h n ' s disease suggests e n v i r o n m e n t a l factors. (Abstract# G4092) JP Hugot, JF Colombel, J B~la~che, JP C~zard, M Peeters, A Van Gossum, R L6fberg, F Pallone, H Zouali, C Gower-Reusseau, JP Gendre and G Thomas. Lille, France C o n c o r d a n c e r a t e s of t w i n s a n d siblings i n i n f l a m m a t o r y bowel disease. (Abstract# G4474) J Subhani, SM Montgomery, RE Pounder and AJ Wakefield. London, United Kingdom M i l i t a r y h i s t o r y of p a t i e n t s w i t h i n f l a m m a t o r y bowel disease. (Abstract# G3942) F Delcb and A Sonnenberg. Albuquerque, NM

F u r t h e r evidence of a n a s s o c i a t i o n b e t w e e n the allele 2 of the i n t e r l e u k i n - 1 r e c e p t o r a n t a g o n i s t gene (IL-1RN) p o l y m o r p h i s m a n d u l c e r a t i v e colitis. (Abstract# G3883) MJ Carter, S Jones, JC Mansfield, FS di Giovine, NJ Camp, AJ Lobo and GW Duff. Sheffield, United Kingdom Does a family h i s t o r y u s e f u l l y p r e d i c t i n f l a m m a t o r y bowel disease b y 26 years? (Abstract# G4273) DL Morris, SM Montgomery, AJ Wakefield and RE Pounder. London, United Kingdom HLA-DRBI*03, b u t n o t t h e TNF-a-308 p r o m o t e r p o l y m o r p h i s m confers p r o t e c t i o n a g a i n s t f i s t u l i z i n g C r o h n ' s disease. (Abstract# G3848) G Bouma, AC Poen, MA Garcia-Gonzfilez, GMT Schreuder, RJF Felt-Bersma, SGM Meuwissen and AS Pefia. Amsterdam and Leiden, The Netherlands

Chromosome i n s t a b i l i t y i n i n f l a m m a t o r y bowel disease. (Abstract# G3923) A Cottliar, A Fundia, Y Slavutsky, L Boerr, J Gomez, A Sambuelli, S Negreira, A Gil, S Huermos, G Camartino, D Felstiner, A Torres, A Jmelniezky, A Bernedo and N Chopita. Buenos Aires and La Plata, Argentina

Genetic m a r k e r s i n clinically well defined p a t i e n t s with ulcerative colitis. (Abstract# G3847) G Bouma, JBA Crusius, MA Garcla-Gonz~lez, BUGA Meijer, HPR HeUemans, GMT Schreuder, G Bioque, PJ Kostense, SGM Meuwissen and AS Pefia. Amsterdam and Leiden, The Netherlands

V i t a m i n D r e c e p t o r gene p o l m o r p h i s m f u r t h e r evidence for a n a s s o c i a t i o n w i t h C r o h n ' s disease. (Abstract# G4446) JD Simmons, C Mullighan, KI Welsh and DP Jewell. Oxford, United Kingdom

Age difference at diagnosis b e t w e e n p a r e n t s a n d c h i l d r e n w i t h i n f l a m m a t o r y bowel disease: genetic a n t i c i p a t i o n or a cohort effect? (Abstract# G4175) JCW Lee and JE Lennard-Jones. Middlesex, United Kingdom

Genetic a n a l y s i s of i n f l a m m a t o r y bowel disease i n a large E u r o p e a n p a t i e n t p o p u l a t i o n s u p p o r t s l i n k a g e to h u m a n c h r o m o s o m e s 12 a n d 16. (Abstract# G3925) ME Curran, KF Lau, L Cardon, H Sakul, TJR Harris, J Hampe, S Schreiber, P Stokkers, SJH van Deventer, A Raedler, W Kruis, P Knoflach, P Wewalka, P Gionchetti, S Bridger, AJS Macpherson, M Mirza, C Mathew, J Lee and JL Jones. La Jolla, CA; Berlin, Hamburg and Cologne, Germany; Amsterdam, The Netherlands; Wels and Linz, Austria; Bologna, Italy and London, United Kingdom A n t i c i p a t i o n i n i n f l a m m a t o r y bowel disease: a p h e n o m e n o n c a u s e d b y a c u m u l a t i o n of confounders. (Abstract# G4059) J Hampe, K Heymann, W Kruis, T Herrmann, A Raedler and S Schreiber. Berlin, Cologne and Hamburg, Germany A low c h i l d h o o d a n t i g e n i c exposure as a risk factor for IBD. (Abstract# G4057) J Hampe, K Heymann, H Lochs and S Schreiber. Berlin, Germany T e s t i n g IBD c a n d i d a t e loci o n chromosome 12: the i n t e r f e r o n g a m m a gene. (Abstract# G4060) J Hampe, B Herrmann, K Sahland, T Herrmann, H Lochs and S Schreiber. Berlin, Germany T N F gene p o l y m o r p h i s m m a y i n f l u e n c e disease

b e h a v i o r i n C r o h n ' s disease. (Abstract# G4208) E Louis, M Peeters, G Demolin, F Croes, P Dupont, P Rutgeerts, J Belaiche and the Belgian IBD Research Group. Liege and Leuven, Belgium D o c u m e n t e d f a m i l i a l i n f l a m m a t o r y bowel disease: tip of the iceberg?. (Abstract# G3861) S Bridget, IC Forgacs, I Bjarnason and AJS Macpherson. London, United Kingdom F a m i l i a l C r o h n ' s disease is m o r e severe t h a n sporadic disease, i r r e s p e c t i v e of age at diagnosis. (Abstract# G3862) S Bridger, I Proctor, IC Forgacs, I Bjarnason and AJS Macpherson. London, United Kingdom

Genetic a n t i c i p a t i o n i n fifteen t h r e e - g e n e r a t i o n families w i t h i n f l a m m a t o r y bowel disease. (Abstract# G4055) S Gurubhagavatula, L Gold, M LaBuda, M Picc0, S Brandt and TM Bayless. Baltimore, MD T e r t i a r y r e f e r r a l p a t i e n t s w i t h C r o h n ' s disease h a v e earlier age of disease onset, s h o r t e r disease d u r a t i o n b u t e q u i v a l e n t f a m i l i a l i t y c o m p a r e d to c o m m u n i t y based p a t i e n t s . (Abstract# G4344) MF Picco, JS Mann, J Reed, III, L Rosen, C D'Angelo, ML Harris and TM Bayless. Baltimore, MD and Allentown, PA A n t i c i p a t i o n i n Crohn's disease m a y be i n f l u e n c e d b y e t h n i c i t y of the t r a n s m i t t i n g p a r e n t . (Abstract# G4053) B Gulwani-Akolkar, D Heresbach, M Lesser, PN Akolkar, XY Lin, N Heresbach-Le Berre, JF Bretagne, S Katz and J Silver. Manhasset, NY and Rennes, France No evidence for l i n k a g e o n c h r o m o s o m e s 16-12-7 a n d 3 i n the Belgian p o p u l a t i o n m a y reflect genetic h e t e r o g e n e i t y of i n f l a m m a t o r y bowel disease. (Abstract# G4539) S Vermeire, M Peeters, R Vlietinck, M Parkes, J Satsangi, D Jewell and P Rutgeerts. Leuven, Belgium and Oxford, United Kingdom Genetics of i n f l a m m a t o r y bowel disease: c o n t r i b u t i o n of the X chromosome. (Abstract# G4410) J Satsangi, S Vermeire, M Parkes, M Peeters, P Vyas, P Rutgeerts and D JeweU. Oxford, United Kingdom and Leuven, Belgium Genetic s u s c e p t i b i l i t y i n a C a n a d i a n i n f l a m m a t o r y bowel disease p o p u l a t i o n . (Abstract# G4443) MS Silverberg, AH Steinhart, RS McLeod, A Griffiths, L Mirea, SB Bull, CN Williams, GR Greenberg, Z Cohen, KA Siminovitch, JD Rioux, MJ Daly, T Green, V Stone, T Hudson and ES Lander. Toronto and Halifax, Canada; Cambridge, MA

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C o n t r i b u t i o n of HLA class II genes to s u s c e p t i b i l i t y to u l c e r a t i v e colitis i n a C a n a d i a n i n f l a m m a t o r y bowel disease p o p u l a t i o n . (Abstract# G4442) MS Silverberg, J Murphy, AH Steinhart, RS McLe0d, A Griffiths, L Mirea, JZ Szyda, SB Bull, CN Williams, GR Greenberg, Z Cohen, JA Wade, KA Siminovitch, JD Rioux, MJ Daly, T Hudson and ES Lander. Toronto and Halifax, Canada; Cambridge, MA Homozygosity for m e t h y l e n e r e d u c t a s e C677T v a r i a n t is associated w i t h low folate a n d h y p e r h o m o c y t e i n e m i a i n i n f l a m m a t o r y bowel disease p a t i e n t s : i m p o r t a n t c l i n i c a l implications. (Abstract# G4221) N Mahmud, A Molloy, J McPartlin, JM Scott and DG Weir. Dublin, Ireland IMMUNOLOGY, MICROBIOLOGY, AND INFLAMMATORY DISORDERS - - MICROBIAL PATHOGENESIS

DDW Poster of Distinction: Oligosaccharides c o n t a i n i n g sialic acid a n d Na c e t y l g l u c o s a m i n e m e d i a t e Clostridium difficile toxin B b i n d i n g a n d biologic effects i n h u m a n colonic mucosa. (Abstract# G3889) I Castagliuolo, L Valenick, M Riegler, JT LaMont and C Pothoulakis. Boston, MA

Saccharomxces boulardii p r o t e a s e i n h i b i t s Clostrieh'um diHicile t o x i n A- a n d B - i n d u c e d effects i n h u m a n

MAY

19, 1998

Antisense-oligonucleotides a g a i n s t NF-KB as t r e a t m e n t for e x p e r i m e n t a l f u l m i n a n t septic shock i n d u c e d b y e n t e r o b a c t e r i a . (Abstract# G4414) JF Schlaak, AP Barreiros, P Schirmacher, S Petersson, S Borg, K-H Meyer zum Biischenfelde and M Neurath. Mainz, Germany and Huddinge, Sweden Delayed a n d s u p p r e s s e d c y t o k i n e p r o d u c t i o n i n the liver is associated with lethal septic shock i n mice infected w i t h S. typl~'murium. (Abstract# G3798) AP Barreir0s, P Schirmacher, R Laufenberg-Feldmann, KH Meyer zum B~ischenfelde and JF Schlaak. Mainz, Germany I d e n t i f i c a t i o n of c a n d i d a t e b a c t e r i a l p a t h o g e n s i n ulcerative colitis u s i n g a disease-specific m a r k e r antibody. (Abstract# G3906) O Cohavy, AB Tayebali, PK Phu, MP Eggena, D Bruckner, G Harth, M Horwitz, S Targan and J Braun. Los Angeles, CA R o t a v i r u s causes i n t e s t i n a l t r a n s p o r t a b n o r m a l i t i e s i n the n e o n a t a l m u r i n e model. (Abstract# G4191) SD Lippe, C Martin, L Zhao, R Shaw, K Dickman and R Burakoff. Mineola and Northport, NY G i a r d i a i n d u c e s p r o l i f e r a t i o n a n d interferon-~ p r o d u c t i o n b y i n t e s t i n a l lymphocytes b u t n o t cytotoxic activity or m i g r a t i o n . (Abstract# G3975) EC Ebert, RE Brolin and AI Roberts. New Brunswick, NJ

colonic mucosa. (Abstract# G3887) I Castagliuol0, L Valenick, M Riegler, JT LaMont and C Poth0ulakis. Boston, MA

CD b u t n o t UC e n t e r i c b a c t e r i a i n d u c e p r o i n f l a m m a t o r y cytokines. (Abstract# G3922) J Costable, T Bui, R Cerchia, C Werner, J McDonald, CC Ginocchio and GE Mullin. Manhasset, NY

A d h e r e n c e of Vibrio cholcrae to HT29 cells is r e d u c e d b y t h e absence of b a c t e r i a l n e u r a m i n i d a s e a n d with cells s t a b l y e x p r e s s i n g a CFTR a n t i s e n s e t r a n s c r i p t . (Abstract# G3758) M Abely, A Harris, J Kaper, S Wei and D Mack. Oxford, United Kingdom, Omaha, NE and Baltimore, MD

Virulence factors of Escheric/u'a colistrains i s o l a t e d from ileal m u c o s a i n Crohn's disease. (Abstract# G3930) A Darfeuille-Michaud, C Neut, E Lederman, N Barnich, P Di Martino, P Desreumaux, L Gambiez, A Cortot, B Joly and JF Colombel. Lille, France

Apoptosis of h u m a n i n t e s t i n a l epithelial cells i n d u c e d by enteroinvasive bacteria requires bacterial entry and r e p l i c a t i o n / p r o t e i n s y n t h e s i s b u t n o t epithelial Fas expression. (Abstract# G4134) JM Kim, L Eckmann, TC Savidge and MF Kagnoff. La Jolla, CA and Birmingham, United Kingdom

C. difficile toxins A a n d B block p h o s p h o r y l a t i o n of focal a d h e s i o n k i n a s e i n Chinese h a m s t e r ovary a n d colonic a d e n o c a r c i n o m a (T84) cells. (Abstract# G3897) ML Chen, C Pothoulakis, H He, M Wamy and JT LaM0nt. Boston, MA Decreased electrical r e s i s t a n c e i n h u m a n colonic a n d d u o d e n a l m o n o l a y e r s exposed to Giardia lamblia is associated w i t h r e a r r a n g e m e n t of F - a c t i n i n the t e r m i n a l web. (Abstract# G4493) DA Teoh, D Kamieniecki, G Pang and A Buret. Calgary, Canada and South Wales, Australia G i a r d i a s i s i n T cell deficient a n d i m m u n o c o m p e t e n t mice: effects o n p a r a s i t i c load, d i s a c c h a r i d a s e s a n d i n t e r l e u k i n - 6 i n t h e j e j u n u m . (Abstract# G3871) A Buret, MR Logan, GM Klammer, DA Teoh and D Kamieniecki. Calgary, Canada Effect of h u m a n r e c o m b i n a n t interferon-7 o n Salmonella typl~'murium i n v a s i o n i n c u l t u r e d h u m a n i n t e s t i n a l cells. (Abstract# G4354) JF P0schet, RCG P0110k and PD Fairclough. London, United Kingdom

The role of Cryptosporiclium parvum d e r i v e d phospholipase i n m e d i a t i n g e n t e r i c host cell i n v a s i o n in vitro. (Abstract# G4353) RCG Pollok and MJG Farthing. London, United Kingdom IMMUNOLOGY, MICROBIOLOGY, AND INFLAMMATORY DISORDERS - - HELICOBACTER PYLORI: BACTERIOLOGY AND IMMUNOLOGY

DDW Poster of Distinction: Orally i m m u n i z e d ~MT a n t i b o d y deficient mice are protected a g a i n s t H. felis infection. (Abstract# G4293) JG Nedrud, TG Blanchard, R Redline, N Sigmund and SJ Czinn. Cleveland, OH

DDW Poster of Distinction: Helieobactcrpxlori genes i n v o l v e d i n n a t u r a l t r a n s f o r m a t i o n . (Abstract# G4450) LC Smeets, JJE Bijlsma, EJ Kuipers, CMJE Vandenbr0ucke-Grauls and JG Kusters. Amsterdam, The Netherlands

DDW Poster of Distinction: Helicobacter pylori i n p r e - C o l u m b i a n m u m m i e s . (Abstract# G3919) P Correa, D Willis, MJ Allison and E Gerszten. New Orleans, LA; Cincinnati, OH and Richmond, VA

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A G A P O S T E R S E S S I O N - - T U E S D A Y , M A Y 19, 1998

DDW Poster of Distinction: HP33, a dprA homolog, is r e q u i r e d for DNA t r a n s f o r m a t i o n of Helicobacterpylo~. (Abstract# G3771) T Ando, DA Israel, K Kusugami and MJ Blaser. Nashville, TN and Nagoya, Japan P r o d u c t i o n of anti-CagA IgG correlates w i t h IL-8 i n d u c t i o n i n h u m a n gastric m u c o s a l o r g a n culture. (Abstract# G0230) T Ando, GI Perez-Perez, K Kusugami, M Ohsuga and MJ Blaser. Nagoya, Japan and Nashville, TN Role of the h o s t i n Helicobacter-associated gastritis. (Abstract# G4119) R Jump, TG Blanchard, R Redline, JG Nedrud, BM Zagorski and SJ Czinn. Cleveland, OH Role of ENA-78 i n Helicobacterpylori-associated gastritis. (Abstract# G4375) G Rieder, W Einsiedl, RA Hatz, A Walz, M Stolte and G Enders. Munich and Bayreuth, Germany; Bern, Switzerland R e g i o n a l differences of mucosal c h e m o k i n e p r o d u c t i o n i n gastritis a c c o m p a n i e d with H. pylori-positive peptic ulcer. (Abstract# G4409) Y Sato, K Sugimura, T Mochizuki, H Suriki, K Tashiro, K Ishizuka, T Honma, R Narisawa and H Asakura. Niigata, Japan P o s t - i m m u n i z a t i o n gastritis i n Helicobacter i m m u n i z e d / c h a l l e n g e d mice. (Abstract# G3830) TG Blanchard, SJ Czinn, R Redline, N Sigmund and JG Nedrud. Cleveland, OH The role of m o u s e s t r a i n a n d n o r m a l flora i n the r e s p o n s e of mice to cholera t o x i n a n d Helicobacter v a c c i n a t i o n . (Abstract# G3974) KA Eaton, SJ Danon and S Krakowka. Columbus, OH Acid r e g u l a t i o n of i n t e r n a l u r e a s e of Helieobaeter pyloriis e s s e n t i a l for gastric colonization. (Abstract# G4429) DR Scott, D Weeks, G Sachs, M Rektorschek, KP Schafer and K Melchers. Los Angeles, CA and Constance, Germany E v i d e n c e for Helicobaeterpj~lorl specific IgG secretion b y the h u m a n gastric mucosa. (Abstract# G3967) G Dorta, P Pescatore, P Wiesel, N Porta, E Saraga, P Michetti, AL Blum and I Corth~sy-Theulaz. Lausanne, Switzerland and Boston, MA The g a s t r o - d u o d e n a l T cell r e c e p t o r r e p e r t o i r e i n n o r m a l a n d Helieobaeterpyloriinfected mucosa. (Abstract# G3901) Y Chowers, D Coscas, I Barshack, A Horowitz, A Jonas, G Rechavi, S Bar-Melt and N Amariglio. Tel Hashomer, Israel E x p r e s s i o n of HLA-DR, b u t n o t ICAM-1 or B7 as c o s t i m u l a t o r y molecules b y gastric epithelial cells i n Helicobacterpylo~-associated gastritis. (Abstract# G4077) K Higuchi, T Arakawa, T Uchida, T Watanabe, K Tominaga, O Takaishi, Y Fujiwara, J Hara, S Nakamura, T Fukuda, T Matsumoto, K Kobayashi and T Kuroki. Osaka, Japan Direct m o d u l a t i o n of cytokine p r o d u c t i o n b y H. pylori. (Abstract# G4253) F Meyer and SP James. Baltimore, MD

The i d e n t i f i c a t i o n a n d c h a r a c t e r i z a t i o n of a differentially expressed locus i n Helieobacterpylori u s i n g a r b i t r a r i l y p r i m e d PCR of RNA. (Abstract# G3970) WG Dundon, DG Marshall and CJ Smyth. Dublin, Ireland Urease-negative v a r i a n t s of H. pyloriisolated from gastric m u c o s a of p a t i e n t s w i t h p e p t i c u l c e r a n d c h r o n i c gastritis. (Abstract# G4481) J Suzuki, H Muraoka, A Kataoka, T Tsuchida, N Ueda, H Ohno, I Kobayashi, T Mine and T Fujita. Tokyo, Japan Tagged r a n d o m i n s e r t i o n m u t a g e n e s i s of Helicobacter

pylori. (Abstract# G3821) JJE Bijlsma, CMJE Vandenbroucke-Grauls and JG Kusters. Amsterdam, The Netherlands

H. pylori s u r v i v e s u n d e r a n a e r o b i c e n v i r o n m e n t a n d m a y use H ÷ as t e r m i n a l e l e c t r o n acceptor. (Abstract# G3963) P Doig, B Noonan, P Krishnamurthy, S Phadnis, N Vakil, B Dunn and T Trust. Milwaukee, WI and Boston, MA S u r f a c t a n t p r o t e i n D e x p r e s s i o n i n n o r m a l a n d H.

pylorl-infected h u m a n gastric a n t r a l mucosa. (Abstract# G4213) S MacDonald, MR Thursz, P Eggleton, KBM Reid and MM Walker. London and Oxford, United Kingdom Ablation of fucosyl t r a n s f e r a s e homologs has v a r y i n g effect on H. pyloriLewis a n t i g e n expression. (Abstract# G3984) EM E1-Omar, SA Thompson and MJ Blaser. Nashville, TN RANTES e x p r e s s i o n p e r s i s t e d for l o n g t e r m after H.

pylorieradication. (Abstract# G4131) T Kikuchi, K Kato, S Ohara, H Sekine, T Arikawa, K Honda, T Suzuki, K Noguchi, Y Konno, N Dairaku, S Asaki and T Toyota. Sendal, Japan H u m a n sera from Helicobacterpylorl-infected p a t i e n t s i n h i b i t s Helicobacter pylori m o t i l i t y in vitro. (Abstract# G4545) P Voland, JA Hiura, DR Scott, D Vaira and G Sachs. Los Angeles, CA and Bologna, Italy Exogenous s o m a t o s t a t i n s u p p r e s s e s Helicobacterpylori p r o l i f e r a t i o n in vitro. (Abstract# G4579) K Yamashita, H Kaneko, T Konagaya, S Yamamoto, K Kusugami and T Mitsuma. Aichi and Nagoya, Japan Effect of t h e r a p e u t i c v a c c i n a t i o n a g a i n s t Helicobacter pyloriinfection a n d i m m u n e r e s p o n s e s i n e x p e r i m e n t a l mouse model. (Abstract# G4305) A Nishizono, T Gotoh, J Ikewaki, M Kimoto, T Fujioka, M Nasu and K Mifune. Oita, Japan E x p r e s s i o n of IL-10 a n d IL-12 (p40) mRNA i n Helieobaeterpyloriinfected g a s t r i c mucosa: r e l a t i o n s h i p to b a c t e r i a l eagstatus. (Abstract# G4074) N Hida, T Shimoyama, SM Farmery, MF Dixon, ATR Axon and JE Crabtree. Leeds, United Kingdom and Hyogo, Japan E x p r e s s i o n of h e a t shock p r o t e i n s hsp60 a n d hsp32 is i n c r e a s e d i n H. pylori-infected g a s t r i c mucosa. (Abstract# G3803) SGRG Barton, S Jordan, VR Winrow, P Domizio and DS Rampton. London, United Kingdom Survival of H. pylorlafter e x p o s u r e to h y d r o g e n peroxide is u n r e l a t e d to CagA s t a t u s . (Abstract# G3804) SGRG Barton, KA Young, JM Hardie and DS Rampton. London, United Kingdom

P168PROG~ OFTHEANNUALMEETING I

AGA POSTI~R

GASTROENTEROLOGY Vol.114,No.4 SESSION

CagA s t a t u s is r e l a t e d to r a i s e d s e r u m IgA a n t i b o d i e s to 60kDa h e a t shock p r o t e i n s i n gastric a t r o p h y associated w i t h H. pyloriinfection. (Abstract# G3801) SGRG Barton, VR Winrow, I Beales, J Calam, JE Crabtree and DS Rampton. London and Leeds, United Kingdom The role of Hvlicobacter pylori flavodoxin e n c o d i n g gene (HdA) i n m e t r o n i d a z o l e resistance. (Abstract# G4164) DH Kw0n, J Versalovic, CL Perng, JS Woo, DY Graham, MF Go, FAK E1-Zaatari, P Kaihovaara and M Salaspuro. Houston, TX and Helsinki, Finland HORMONES, TRANSMITTERS, GROWTH FACTORS AND T H E I R R E C E P T O R S - - MOLECULAR BIOLOGY

DDW Poster of Distinction: Novel h u m a n IL-17 r e c e p t o r s expressed i n i n t e s t i n a l epithelial cells. (Abstract# G4802) HC Reinecker, DK Podolsky and DJ Li. Boston, MA Goblet cell-specific t r a n s c r i p t i o n of the i n t e s t i n a l trefoil factor r e s u l t s from c o l l a b o r a t i o n of distinctive positive a n d n e g a t i v e r e g u l a t o r y elements. (Abstract# G4713) H Itoh, N Inoue and DK Podolsky. Boston, MA I s o l a t i o n a n d c h a r a c t e r i z a t i o n of EGFR-related cDNA from r a t gastric mucosa. (Abstract# G4883) Y Yu, JA Moshier, S Kulkarni, A Khan, R Jaszewski, L Liu and APN Majumdar. Detroit, MI I n d u c e d p r o s t a g l a n d i n synthase-2 e x p r e s s i o n b y GRP is n o t d e p e n d e n t o n a n ATF/CRE t r a n s c r i p t i o n r e s p o n s e element. (Abstract# G4830) LW Slice, J Duque and JH Walsh. Los Angeles, CA S o m a t o s t a t i n type 2 r e c e p t o r i n h i b i t i o n of h i s t i d i n e decarboxylase t r a n s c r i p t i o n is n o t m e d i a t e d t h r o u g h a p h o s p h a t a s e p a t h w a y i n the h u m a n gastric c a n c e r cell l i n e AGS-B. (Abstract# G4702) RDJ Henihan, R Colucci, Z Zhang and TC Wang. Boston, MA C o r r e l a t i o n of DNA m e t h y l a t i o n w i t h s i l e n c i n g of the n e u r o t e n s i n / n e u r o m e d i n N gene i n the developing liver. (Abstract# G4859) X-f Wang, Z D0ng, X-m Wang and BM Evers. Galveston, TX P r e s e n c e of a n o v e l cis e l e m e n t i n the distal s e g m e n t of the IGF-II P3 p r o m o t e r t h a t specifically b i n d s n u c l e a r p r o t e i n s from p r o l i f e r a t i n g colon c a n c e r cells (CaCo-2). (Abstract# G4658) B Dai, S Widen and P Singh. Galveston, TX Cell-specific e x p r e s s i o n of the n e u r o t e n s i n / n e u r o m e d i n N gene is d e p e n d e n t o n CIS e l e m e n t s i n b o t h the p r o m o t e r a n d first i n t r o n . (Abstract# G4663) Z D0ng, X-f Wang, Q-m Ding and BM Evers. Galveston, TX Rab-GDP d i s s o c i a t i o n i n h i b i t o r e x p r e s s i o n a n d localization i n d i s p e r s e d p a r o t i d a c i n i from rat. (Abstract# G4641) S Chan, J Lin and RD Raffaniello. Brooklyn, NY HORMONES, TRANSMITTERS, GROWTH FACTORS AND T H E I R R E C E P T O R S - - NEUROBIOLOGY

DDW Poster of Distinction: C h a r a c t e r i z a t i o n , d i f f e r e n t i a l localization a n d splice v a r i a n t s of n i t r i c oxide s y n t h a s e i n r a t small i n t e s t i n e . (Abstract# G4816) D Saur, A Huber and HD Allescher. Munich, Germany

-- TUESDAY,

M A Y 19, 1 9 9 8

Nitric oxide s t i m u l a t e s b o m b e s i n release f r o m e n t e r i c s y n a p t o s o m e s by c r o s s a c t i v a t i o n of p r o t e i n k i n a s e A. (Abstract# G4735) M Kurjak, R Fritsch and HD Allescher. Munich, Germany The effect of acetylcholine o n i n t r a c e l l u l a r c a l c i u m c o n c e n t r a t i o n i n c u l t u r e d m y e n t e r i c n e u r o n s is m e d i a t e d b y b o t h n i c o t i n i c a n d m u s c a r i n i c receptors. (Abstract# G4853) P Vanden Berghe, J Tack, A Andrioli, B Coulie, L Missiaen and J Janssens. Leuven, Belgium IL-1 ~ s t i m u l a t e s release of s u b s t a n c e P a n d n e u r o t e n s i n a n d i n c r e a s e s e x p r e s s i o n of t h e i r r e c e p t o r s o n l a m i n a p r o p r i a macrophages. (Abstract# G4638) I Castagliuolo, C Wang, GJ Previte, A Pasha and C Pothoulakis. Boston, MA

DDW Poster of Distinction: Neurotrophin-3 is r e q u i r e d for d i f f e r e n t i a t i o n of i n t e s t i n a l m u c o s a l n e u r o n s a n d i n n e r v a t i o n of epithelial cells i n culture. (Abstract# G4615) J Belkind-Gerson, R Choi and LM Kaplan. Boston, MA Glial cell line-derived n e u r o t r o p h i c factor i n c r e a s e s the expression of s u b s t a n c e P b y c u l t u r e d m y e n t e r i c n e u r o n s . (Abstract# G4696) JR Grider. Richmond, VA Substance P evokes a rise i n i n t r a c e l l u l a r c a l c i u m c o n c e n t r a t i o n i n c u l t u r e d m y e n t e r i c n e u r o n s via a n inositol t r i p h o s p h a t e p a t h w a y . (Abstract# G4852) B Vanden Berghe, J Tack, B Coulie, L Missiaen and J Janssens. Leuven, Belgium Release of e n d o g e n o u s s u b s t a n c e P a n d n e u r o k i n i n 1 receptor i n t e r n a l i z a t i o n are i n h i b i t e d b y GABAn receptors i n spinal cord slices: i n t e r a c t i o n w i t h NMDA receptors. (Abstract# G4758) JCG MarvizSn, EF Grady, E Stefani, NW Bunnett and EA Mayer. Los Angeles and San Francisco, CA Evidence for efferent f u n c t i o n of dorsal root g a n g l i o n n e u r o n s onto colonic s m o o t h muscle cells i n p r i m a r y culture. (Abstract# G4881) SH Young, HS Ennes and EA Mayer. Los Angeles, CA Mechanically i n s e n s i t i v e dorsal root g a n g l i o n n e u r i t e s show chemical excitability. (Abstract# G4882) SH Young, HS Ennes and EA Mayer. Los Angeles, CA Gap j u n c t i o n - m e d i a t e d i n t e r c e l l u l a r c o m m u n i c a t i o n b e t w e e n DRG n e u r o n s a n d t h r e e t a r g e t cell types. (Abstract# (]4668) HS Ennes, SH Young, J Goliger, J McRoberts and EA Mayer. Los Angeles, CA Role of s p i n a l receptors for NMDA, NK-1 a n d CGRP i n visceral p a i n r e s p o n s e to colorectal d i s t e n s i o n . (Abstract# G4699) JM Gschossmann and EA Mayer. Los Angeles, CA I n h i b i t o r y r e g u l a t i o n of a d e n y l y l cyclase types VNI i n smooth muscle is m e d i a t e d b y i n t e r p l a y of Gi3 a n d Ca 2+ influx. (Abstract# G4775) KS Murthy and GM Makhl0uf. Richmond, VA I n v o l v e m e n t of p i t u i t a r y a d e n y l a t e cyclase a c t i v a t i n g p e p t i d e i n the i n t e r n a l a n a l s p h i n c t e r s m o o t h muscle relaxation. (Abstract# G4640) S Chakder and S Rattan. Philadelphia, PA

[I

April1998

PROGRAM OF THE ANNUAL MEETING P169

AGA POSTER SESSION N e u r o t e n s i n i n d u c e s chloride secretion i n h u m a n colonic m u c o s a t h r o u g h a n a d e n o s i n e - d e p e n d e n t p a t h w a y . (Abstract# G4804) M Riegler, I Castagliuolo, JB Mathhews, M Mlk, T Sogukoglu, E Wenzl and C Pothoulakis..Boston, MA and Vienna, Austria S u b s t a n c e P - i n d u c e d chloride secretio~ i n h u m a n colon is m e d i a t e d b y i n t e s t i n a l n e r v e s a n d m a s t cells a n d a t y r o s i n e k i n a s e - d e p e n d e n t pathway. (Abstract# G4805) M Riegler, I Castagliu01o, PTC So, M L0tz, C Wang, M Wlk, T Sogukoglu, E Cosentini, G Bischof, G Hamilton, B Teleky, E Wenzl, JB Matthews and C P0thoulakis. Cambridge, MA and Vienna, Austria I n f l a m m a t i o n - i n d u c e d i m p a i r m e n t of cholinergic n e r v e f u n c t i o n is CD4 i n d e p e n d e n t i n n e m a t o d e - i n f e c t e d mice. (Abstract# G4700) EM Haapala, FA Blennerhassett, BA Vallance and SM Collins. Hamilton, Canada P r o t e i n a s e - a c t i v a t e d receptors o n m y e n t e r i c n e u r o n s : a c t i v a t i o n b y t h r o m b i n a n d m a s t cell tryptase. (Abstract# G4653) CU Corvera, K McConalogue, P Gamp, GH Caughey and NW Bunnett. San Francisco, CA HORMONES, TRANSMITTERS, GROWTH FACTORS AND T H E I R R E C E P T O R S - - BIOLOGY OF GROWTH FACTORS I

DDW Poster of Distinction: SHP-2 t y r o s i n e p h o s p h a t a s e associates w i t h sst2 s o m a t o s t a t i n receptor. (Abstract# G4749) F Lopez, G Fe~oux, N Saint-Laurent, JP Est~ve, E Vivier, F V~ly, L Buscail, N Vaysse and C Susini. Toulouse and Marseille, France Role of n i t r i c oxide i n the a n t i p r o l i f e r a t i v e signal m e d i a t e d b y the s o m a t o s t a t i n r e c e p t o r sst5. (Abstract# G4651) P Cordelier, J-P Est~ve, P Rochaix, JJ Voigt, AV Schally, N Vaysse, C Susini and L Buscafl. Toulouse, France and New Orleans, LA

~ T U E S D A Y , M A Y 19, 1998 Glycine-extended g a s t r i n 17-1 a n d g a s t r i n 17-1 p r o m o t e p r o l i f e r a t i o n a n d DNA s y n t h e s i s i n m u r i n e m e s a n g i u m cells in vitro. (Abstract# G4660) A de Weerth, A Pace, M Azizi, H Greten and T von Schrenck. Hamburg, Germany P r o g a s t r i n a n d glycine e x t e n d e d gastrin-17 are overexpressed i n p e r n i c i o u s a n e m i a p a t i e n t s . (Abstract# G4831) AM Smith, A Varro, SA Watson and JD Hardcastle. Nottingham and Liverpool, United Kingdom E x p r e s s i o n a n d r e g u l a t i o n of Bcl-2 a n d Bax i n p a r i e t a l a n d chief cells. (Abstract# G4781) B Neu, H Herrmuth, F Ernst, W Vaupel, W Reindl, N Endres, MJ Atkinson, M Classen and W Schepp. Munich, Germany P l a s m a c h r o m o g r a n i n A is r e l a t e d to e n t e r o c h r o m a f f i n like cell p r o l i f e r a t i o n d u r i n g m e d i u m a n d long t e r m gastric acid i n h i b i t i o n . (Abstract# G4813) S Sanduleanu, A de Bruine, M Stridsberg, W Hameeteman, JW Arends, G Lundquist and R Stockbr~igger. Maastricht, The Netherlands and Uppsala, Sweden A n t r e c t o m y obviates gastric c a r c i n o i d f o r m a t i o n even i n a genetically p r e d i s p o s e d model Mastomys. (Abstract# G4769) IM Modlin, T Zhang, M Kidd, S Schmid, D Chen and L Tang. New Haven, CT S e r u m c h r o m a g r a n i n A as a m a r k e r of disease presence, extent or a c t i v i t y i n p a t i e n t s w i t h g a s t r i n o m a . (Abstract# G4689) SU Goebel, F Gibril, F Yu, J Serrano and RT Jensen. Bethesda, MD E x p r e s s i o n of the v e s i c u l a r m o n o a m i n e t r a n s p o r t e r s I a n d II i n gastric e n d o c r i n e cell h y p e r p l a s i a a n d gastric carcinoids. (Abstract# G4666) R Eissele, M Anlauf, MKH Sch~fer, LE Eiden, M Frank, R Arnold and E Weihe. Marburg, Germany and Bethesda, MD

A l t e r a t i o n s of s o m a t o s t a t i n a n d its type-2 r e c e p t o r e x p r e s s i o n i n the gastric m u c o s a of Mastomys d u r i n g the d e v e l o p m e n t of c a r c i n o i d tumors. (Abstract# G4889) T Zhang, L Tang, J L~uffer, M Kidd and IM Modlin. New Haven, CT

A prospective s t u d y of gastric localization i n p a t i e n t s w i t h Zollinger-Ellison s y n d r o m e w i t h s o m a t o s t a t i n r e c e p t o r s c i n t i g r a p h y a n d its association w i t h the p r e s e n c e of gastric c a r c i n o i d t u m o r s . (Abstract# G4683) F Gibril, JC Reynolds, CC Chen, J Serrano, SU Goebel, F Yu, IA Lubensky, JA Norton and RT Jensen. Bethesda, MD and San Francisco, CA

DDW Poster of Distinction:

DDW Poster of Distinction:

The h u m a n h i s t a m i n e H 2 r e c e p t o r regulates c-jun a n d c-fos i n a d i f f e r e n t i a l m a n n e r . (Abstract# G4857) L Wang, M Wang, A Todisco and J Del Valle. Ann Arbor, MI

An aggressive a n d a n o n a g g r e s s i v e form of disease exists i n p a t i e n t s w i t h m u l t i p l e e n d o c r i n e n e o p l a s i a type I a n d Zollinger-Ellison syndrome. (Abstract# G4684) F Gibril, J Serrano, F Yu, SU Goebel and RT Jensen. Bethesda, MD

The h i s t a m i n e H 2 r e c e p t o r s t i m u l a t e s e-los t r a n s c r i p t i o n a n d cell p r o l i f e r a t i o n via a MAP kinased e p e n d e n t m e c h a n i s m . (Abstract# G4856) L Wang, M Wang, A Todisco, T Suzuki and J Del Valle. Ann Arbor, MI CAMP-dependent s i g n a l l i n g p a t h w a y s r e g u l a t e the h u m a n h i s t i d i n e decarboxylase p r o m o t e r t h r o u g h a c t i v a t i o n of MAPK/ERK cascades i n gastric c a n c e r cells. (Abstract# G4705) M H6cker, T Plath, B Wiedenmann, EO Riecken, S R0sewicz and TC Wang. Berlin, Germany and Boston, MA Cell type specific r e q u i r e m e n t of the MAPK p a t h w a y for t h e g r o w t h factor a c t i o n of gastrin. (Abstract# G4838) V Stepan, CJ Dickinson, J Del Valle and A T0disc0. Ann Arbor, MI

In vivo m o d u l a t i o n of t h e h e p a t i c a c u t e p h a s e response after i n j u r y b y h e p a t o c y t e g r o w t h factor. (Abstract# G4716) MG Jeschke, SE Wolf, DN Herndon, MA DebRoy, J Rai, BJ Lichtenbelt, RE Barrow and JC Thompson. Galveston, TX Hepatocyte growth i n h i b i t o r y factor d e r i v e d from HTLV-I(+) T cell line is i d e n t i c a l to IL-6. (Abstract# G4720) Y Kawai, A Yamauchi, H Nakamura, T Inam0t0 and Y Yama0ka. Kyot0, Japan

P170 P R O G R A M OF THE ANNUAL M E E T I N G

G A S T R O E N T E R O L O G Y Vol. 114, No. 4

TUESDAY, MAY 19, 1998 SRC s t i m u l a t e s IGF-I d e p e n d e n t cell g r o w t h i n the h u m a n p a n c r e a t i c c a r c i n o m a cell l i n e PANC1 t h r o u g h o v e r e x p r e s s i o n o f t h e IGF-I receptor. (Abstract# G4674) BBM F10ssmann-Kast, P Jehle, G Adler and MP Lutz. Ulm, Germany

2:15-3:45 p m

E v i d e n c e for i m p a i r e d n e u r o n a l m i t o c h o n d i a l f u n c t i o n i n d i a b e t e s m e l l i t u s . (Abstract# G4837) S Srinivasan, K Hall and JW Wiley. Ann Arbor, MI

Chairs: Douglas R. LaBrecque, David M. Nagorney

DDW Combined Clinical Symposium

Room 90 / 91 / 92 Ernest N. Morial Convention Center

Sponsored b y AASLD/SSAT/AGA

HEPATOCELLULAR CANCER AGA State of the Art Lecture

2:15-3:15 p m

Room 64 / 65 / 66 Ernest N. Morial Convention Center

2:15

Introduction. Douglas R. LaBrecque. Iowa City, IA

2:30

Hepatocarcinogenesis - therapeutic implications. Snorri Th0rgeissen. Bethesda, MD

2:45

Non-surgical a b l a t i o n - c h e m i c a l , t h e r m a l , or embolic? Massimo Colombo. Milan, Italy

3:00

Partial h e p a t e c t o m y - the gold s t a n d a r d ? Yuman F0ng. New York, NY

3:15

Total h e p a t e c t o m y / t r a n s p l a n t a t i o n - t h e n e w gold s t a n d a r d ? Roger Jenkins. Boston, MA

3:30

Panel Discussion David M. Nagorney. Rochester, MN

S p o n s o r e d b y I m m u n o l o g y , Microbiology, and Inflammatory Disorders

Chair:

Joel V. Weinstock

N e u r o - m o d u l a t i o n of g u t i n f l a m m a t i o n . Stephen M. Collins. Hamilton, Canada

AGA State of the Art Lecture

2:15-3:15 p m

Room 58/59 / 60 Ernest N. Morial Convention Center

S p o n s o r e d b y Clinical P r a c t i c e Co-sponsored b y G a s t r o i n t e s t i n a l O n c o l o g y and Intestinal D i s o r d e r s

Chair:

Kris V. Kowdley

Genetic s c r e e n i n g for c o l o n cancer: w h y , w h e n a n d h o w s h o u l d it be used? Randall W. Burt. Salt Lake City, UT

DDW Combined Clinical Symposium

2:15-3:45pm

Room 100/101/102 Ernest N. Morial Convention Center

S p o n s o r e d by: SSAT/AGA/ASGE

Chairs: Andrew L. Warshaw, Peter A. Banks DDW Combined Clinical Symposium

2:15-3:45 p m

Ballroom A / B Ernest N. Morial Convention Center

SEVERE ACUTE PANCREATITIS 2:15

Medical strategy - i n h i b i t i o n o f i n f l a m m a t o r y mediators. James Norman. Tampa, FL

Chairs: Jeffrey L. Ponsky, Lawrence W. Way

2:25

MINIMALLY INVASIVE M A N A G E M E N T OF COMMON BILE DUCT STONES

Radiologic s t r a t e g y - CP scan, aspiration, drainage. Eric van S0nnenberg. Galveston, TX

2:35

Attendees will learn about laparoscopic approaches to managing common bile duct stones, and the integration of ERCP and laparoscopic techniques.

E n d o s c o p i c strategy - ERCP, s t e n t i n g , drainage. Richard A. Kozarek. Seattle, WA

2:45

Surgical s t r a t e g y - e a r l y surgery, late surgery, or n o surgery. Carlos Fernandez-del Castillo. Boston, MA

2:55

Case Presentations.

Sponsored by: ASGE/SSAT/AASLD/AGA

2:15

Laparoscopic t r a n s c y s t i c stone extraction. Joseph Petelin. Kansas City, KS

2:40

Laparoscopic c h o l e d o c h o t o m y . Lawrence W. Way. San Francisco, CA

3:05

3:30

Integration o f l a p a r o s c o p i c a n d ERCP for c o m m o n b i l e d u c t stones. Jeffrey L. Ponsky. Cleveland, OH Discussion

AGA Clinical Symposium

2:15-3:45 p m

Room 4 1 / 4 2 / 4 3 Ernest N. Morial Convention Center

Sponsored b y Esophageal, Gastric, a n d D u o d e n a l Disorders Co-sponsored b y Clinical Practice

Chair:

Loren A. Laine

CONTROVERSIES IN U P P E R GI BLEEDING: AN EVIDENCE-BASED APPROACH Antisecretory t h e r a p y in acute ulcer b l e e d i n g . Walter L. Peterson. Dallas, TX

Use of s o m a t o s t a t i n / o c t r e o t i d e for n o n - v a r i c e a l hemorrhage. Philip S. Schoenfeld. Bethesda, MD

April1998

PROGRAMOF THEANNUALMEETINGP171

TUESDAY, MAY 19, 1998 AGA Clinical Symposium

AGA Research Symposium

2:15-3:45 p m

2:15-3:45 p m

Room 99 Ernest N. Morial Convention Center

S p o n s o r e d b y E s o p h a g e a l , Gastric, and D u o d e n a l Disorders Co-sponsored b y M o t i l i t y and Nerve-Gut Interactions

Sponsored b y Hormones, T r a n s m i t t e r s , Growth F a c t o r s a n d t h e i r Receptors

Chair: Chair:

Room 97/98 Ernest N. Morial Convention Center

Rodger A. Liddle

Peter J. Kahrilas

M A N A G E M E N T OF ACHALASIA LES physiology a n d the p a t h o p h y s i o l o g y of achalasia. Chander Singaram. Galveston, TX

R a t i o n a l e a n d efficacy of botox i n j e c t i o n as t h e r a p y of achalasia. Pankaj J. Pashricha. Galveston, TX P n e u m a t i c d i l a t i o n v e r s u s o t h e r t h e r a p i e s of achalasia. Joel E. Richter. Cleveland, OH L a p a r a s c o p i c Heller myotomy. Carlos A. Pellegrini. Seattle, WA P a n e l discussion: Which t h e r a p y when?

P U R I N E R G I C RECEPTORS IN T H E GASTROINTESTINAL TRACT A u t o c r i n e r e g u l a t i o n of cell v o l u m e t h r o u g h r e g u l a t e d release of ATP. J. Gregory Fitz. Denver, CO Molecular m e c h a n i s m s of ATP release. Richard Roman. Denver, CO Effects of n u c l e o t i d e s o n i o n t r a n s p o r t i n the GI t r a c t a n d gallbladder. Barbara R. Grubb. Chapel Hill, NC AGA Topic Forum

2:15-3:45 p m

Room 33/35 Ernest N. Morial Convention Center

AGA Research Symposium

2:15-3:45 p m

Room 89 Ernest N. Morial Convention Center

Chairs: Nezam H. Afdhal, Claudia Sama PATHOPHYSIOLOGY OF BILIARY DISEASES

S p o n s o r e d b y Growth, Development, N u t r i t i o n Co-sponsored b y Hormones, T r a n s m i t t e r s , Growth F a c t o r s a n d t h e i r :Receptors a n d G a s t r o i n t e s t i n a l Oncology

Chair:

H e p a t o b i l i a r y tteiicobacter spp. i d e n t i f i e d from p a t i e n t s with p r i m a r y sclerosing cholangitis. (Abstract# G4009) JG Fox, Z Shen, F Feng, J Duf0ver, MM Kaplan and F Dewhirst. Cambridge and Boston, MA

2:30

The p a t h o g e n e s i s of g a l l b l a d d e r a d e n o m a t o u s polyps is different from t h a t of gallbladder carcinoma. (Abstract# G2247) I Wistuba, JF Miquel, AF Gazdar and J AlboresSaavedra. Dallas, TX and Santiago, Chile

2:45

A highly simplified m e t h o d for p l a s m a a n d fecal bile acid analysis i n h u m a n s . (Abstract# G2098) AK Batta, G Salen, KR Rapole, M Batta, D Alberts and D Earnest. Newark and East Orange, NJ; Tucson, AZ

3:00

P r o l i f e r a t i v e p o t e n t i a l a n d K-ras m u t a t i o n i n epithelial h y p e r p l a s i a of t h e gallbladder i n patients with anomalous pancreaticobiliary ductal u n i o n . (Abstract# G2227) S Tann0, T Obara, T Izawa, T Fujii, N Nishin0, H Ura and Y Kohgo. Asahikawa, Japan

3:15

Positive i n t r a o p e r a t i v e bile c u l t u r e s at the time of p a n c r e a t i c o d u o d e n e c t o m y are associated w i t h p r e o p e r a t i v e b i l i a r y d r a i n a g e a n d s u b s e q u e n t d e v e l o p m e n t of p o s t o p e r a t i v e infectious c o m p l i c a t i o n s a n d mortality. (Abstract# G2194) SP Povoski, MS Karpeh, KC Conlon, LH Blumgart and MF Brennan. New York, NY

3:30

Effect of bile acids o n l i p i d p e r o x i d a t i o n : role of iron. (Abstract# G2217) N Sreejayan and C v0n Ritter. Munich, Germany

Vincent Yang

R E G U L A T I O N OF T R A N S C R I P T I O N AND APOPTOSIS IN T H E GUT E P I T H E L I U M Molecular m e c h a n i s m s of colorectal cancer i n i t i a t i o n . Patrice M0rin. Baltimore, MD Apoptosis i n t h e g a s t r o i n t e s t i n a l tract. Chris Potten. Manchester, England I d e n t i f i c a t i o n of a m a s t e r r e g u l a t o r y gene for differentiation of secretin-expressing enteroendocrine cells i n the GI tract. Andrew B. Leiter. Boston, MA AGA Research Symposium

2:15-3:45 p m

Room 93/94 Ernest N. Morial Convention Center

S p o n s o r e d b y G a s t r o i n t e s t i n a l Oncology Co-sponsored b y Growth, Development, N u t r i t i o n a n d Hormones, T r a n s m i t t e r s , G r o w t h Factors a n d t h e i r Receptors

Chair:

2:15

Steven H. Itzkowitz

T G F BETA IN CANCER BIOLOGY TGF b e t a a n d its receptors. Sanford Mark0witz. Cleveland, OH DPC4 a n d TGF Beta: P a r t n e r s or s t r a n g e r s ? Scott Kern. Baltimore, MD TGF Beta r e s p o n s i v e n e s s i n colon cancer cells. Eileen Friedman. Syracuse, NY

.P172P R O G R A M

OF THE ANNUAL MEETING

G A S T R O E N T E R O L O G Y Vol. 114~ No. 4

TUESDAY, MAY 19, 1998 AGA Topic Forum

2:15-3:45 p m

3:00

M e t h o t r e x a t e i n C r o h n ' s disease: '~how is it doing?.". (Abstract# G3899) RY Chong, SB Hanauer and RD Cohen. Chicago, IL

3:15

Outcome of p r e g n a n c i e s w h e n f a t h e r s a r e t r e a t e d with 6 - m e r c a p t o p u r i n e for i n f l a m m a t o r y bowel disease. (Abstract# G4366) RO Rajapakse, BI Korelitz, J Zlatanic, PJ Baiocco and GM Gleim. New York, NY

3:30

A z a t h i o p r i n e to m a i n t a i n the r e s p o n s e of acute u l c e r a t i v e colitis to cyclosporin. (Abstract# G3760) GC Actis, G R0cca, M Pinna-Pintor and M Rizzetto. Turin, Italy

Room 37/38 Ernest N. Morial Convention Center

Chairs: M. Brian Fennerty, Colleen Schmitt ECONOMIC O U T C O M E S FOR CLINICAL PRACTICE 2:15

2:30

2:45

3:00

3:15

3:30

A cost-analysis of a l t e r n a t i v e t r e a t m e n t strategies for achalasia. (Abstract# G0076) TF Imperiale, JB O'Connor, MF Vaezi and JE Richter. Indianapolis, IN and Cleveland, OH Cost-effectiveness of v a c c i n e d e v e l o p m e n t for H. pylori u s i n g the I n s t i t u t e of Medicine model. (Abstract# G1279) M Tsugawa, R Shachter, DK Owens and J Parsonnet. Stanford, CA

Gastrointestinal Oncology AGA Research Forum

The cost-effectiveness of the omeprazole test i n n o n - c a r d i a c chest p a i n . (Abstract# G0127) J Ofman, I Gralnek, J Udani and R Fass. Los Angeles, CA and Tucson, AZ

2:15-3:45 p m

S u r v e i l l a n c e w i t h colectomy for low grade d y s p l a s i a i n c r e a s e s l e n g t h a n d q u a l i t y of life i n u l c e r a t i v e colitis p a t i e n t s a n d is cost-effective c o m p a r e d w i t h c o m m o n medical practices. (Abstract# G0142) D Provenzale, M Shearin, JE Onken and JB Wong. Durham and Chapel Hill, NC; Boston, MA

HELICOBACTER PYLORI AND GI CANCER 2:15

High salt diet i n c r e a s e s Helicobacterpy]ori c o l o n i z a t i o n i n C57B1/6 mice. (Abstract# G2841) NS Taylor, JG Fox and CA Dangler. Cambridge and Boston, MA

The GERD outcomes trial: a r a n d o m i z e d s t u d y to assess outcomes a n d costs i n p r i m a r y care practice. (Abstract# G0130) G Oster, D Thompson, S Kaatz, K Anderson, R Cavanaugh, J Crawley, K Johnson, D Schreiber, R Weinberg and D Guflbert. Brookline and Worcester, MA; Detroit, MI; Wayne and Pittsburgh, PA; Providence, RI

2:30

Helicobacterpyloriinduces cyclooxygenase-2

Should liver b i o p s y be d o n e i n a s y m p t o m a t i c p a t i e n t s w i t h c h r o n i c a l l y elevated t r a n s a m i n a s e s - a cost-utility analysis. (Abstract# G0034) A Das and AB Post. Cleveland, OH

Chairs: Robert E. Petras, J. Lawrence Werther

e x p r e s s i o n i n h u m a n gastric e p i t h e l i a l cells by a tyrosine phosphorylation-dependent m e c h a n i s m . (Abstract# G2747) KS Ramanujam and KT Wilson. Baltimore, MD 2:45

Amplification of 3' r e p e a t sequences i n t h e Helicobacterpylori cagA gene is associated w i t h gastric a t r o p h y a n d gastric cancer. (Abstract# G2923) Y Yamaoka, T Kodama, K Kashima, DY Graham and AR Sepulveda. Kyoto, Japan and Houston, TX

3:00

Need for biopsies t a r g e t e d to the cardia, corpus, a n d a n t r u m i n gastric MALT lymphoma. (Abstract# G2422) HMT E1-Zimaity, HM Malaty, DY Graham and O Gutierrez. Houston, TX and Bogota, Colombia

3:15

Histology a n d stage s t r a t i f i e d t h e r a p y offers p r o m i s i n g r e s u l t s i n p r i m a r y gastric n o n Hodgkin's l y m p h o m a : experiences of t h e German-Austrian prospective multicenter trial. (Abstract# G2442) W Fischbach, M-E Kolve, B Dragosics, A Greiner, HK Mfiller-Hermelink, PR Verreet, C Ohmann, M Busch, K Wilms and the German Lymphoma Study Group. Aschaffenburg, W~irzburg, DUsseldorf and Munich, Germany; Vienna, Austria

3:30

Cure of Hclicobactcrpyloriinfection i n 125 w i t h p r i m a r y gastric low-grade MALT lymphoma. (Abstract# G2666) A Morgner, E Bayerd~rffer, A Neubauer, C Thiede, G Pommer, J Hotz, W Simon, O Stadelmann, U FSlsch, C Endres, K Schmeding and M Stolte. Dresden and Bayreuth, Germany

AGA Topic Forum

2:15-3.'45 p m

Room 85/86 Ernest N. Morial Convention Center

Chairs: Mark A. Peppercorn, James F. Markowitz I M M U N O M O D U L A T I O N IN IBD 2:15

Histological c h a n g e s following i n t r a v e n o u s c y c l o s p o r i n e i n t h e t r e a t m e n t of r e f r a c t o r y severe u l c e r a t i v e colitis m a y m i m i c dysplasia. (Abstract# G4096) GM Hyde, BF Warren and DP Jewell. Oxford, United Kingdom

2:30

Is c y c l o s p o r i n e as effective i n c h r o n i c u l c e r a t i v e colitis as i n severe u l c e r a t i v e colitis? (Abstract# G4586) C Yoon, A Kornbluth, J George, M Sternthal, S Lichtiger, J Marion and D Present. New York, NY

2:45

Safety a n d efficacy of a z a t h i o p r i n e a n d 6m e r c a p t o p u r i n e i n the t r e a t m e n t of c h i l d r e n a n d a d o l e s c e n t s w i t h C r o h n ' s disease a n d u l c e r a t i v e colits. (Abstract# G4136) BS Kirschner. Chicago, IL

Room 13 / 15 / 17 Ernest N. Morial Convention Center

April 1998

PROGRAMOF THEANNUALMEETINGP173

TUESDAY, MAY 19, 1998 Hormones, Transmitters, Growth Factors and Their Receptors AGA Research Forum

2:15-3:45 p m

2:45

S u s c e p t i b i l i t y to alcoholic a c u t e p a n c r e a t i t i s i n f l u e n c e d b y t u r n o u t n e c r o s i s factor m i c r o s a t e l l i t e haplotypes. (Abstract# G2014) K Sargen, AG Demaine and AN Kingsnorth. Plymouth, United Kingdom

3:00

Role of t r a n s c r i p t i o n f a c t o r NF-KB i n mediating hormone-induced pancreatitis. (Abstract# G1891) I Gukovsky, TA Blinman, V Zaninovic, Y Jung, AS Gukovskaya and SJ Pandol. Los Angeles, CA

3:15

S p o n t a n e o u s exocrine p a n c r e a t i t i s i n MHC II deficient mice: t r a n s f e r r a b l e b y a u t o r e a c t i v e CD8+ve T cells. (Abstract# G2059) BA Vallance and SM Collins. Hamilton, Canada

3:30

A t t e n u a t i o n of cytosolic c a l c i u m i n c r e a s e i n d u c e d b y abusive s t i m u l a t i o n p r e v e n t s v a c u l o i z a t i o n i n m o u s e p a n c r e a t i c a c i n a r cells. (Abstract# G2069) JB Ward, MGT Raraty, C Vaillant, R Sutton and OH Petersen. Liverpool, United Kingdom

Room 19 Ernest N. Morial Convention Center

Chairs: Richard B. Lynn, Pamela J. Hornby BRAIN-GUT AXIS 2:15

In ~ v o electrochemical detection of n i t r i c oxide release i n the dorsal m o t o r n u c l e u s of the vagus after i n t r a c i s t e r n a l a d m i n i s t r a t i o n of b o m b e s i n . (Abstract# G4617) B Beltr~n, A M~ndez, E Quintero, JL GonzalezMora and JV Esplugues. Valencia, Canarias and Laguna, Spain

2:30

C e n t r a l TRH s t i m u l a t e s gastric f u n c t i o n s t h r o u g h 5-HT4 r e c e p t o r i n rats. (Abstract# G4785) T Nozu, HE Taybould and Y TachS. Los Angeles, CA

2:45

F u n c t i o n a l evidence t h a t the m e d u l l a r y p a r a p y r a m i d a l r e g i o n s p a r t i c i p a t e i n the m e d u l l a r y r e g u l a t i o n of gastric function. (Abstract# G4876) H Yang, PQ Yuan and Y TachS. Los Angeles, CA

3:00

C e n t r a l PYY p r e v e n t s e t h a n o l - i n d u c e d gastric d a m a g e t h r o u g h the a c t i v a t i o n of Y1 and/or PYY-preferring receptors i n a n e s t h e t i z e d rats. (Abstract# G4721) K Kawakubo, H Yang, H Wong, V Wu, G Ohning and Y TachS. Los Angeles, CA

3:15

Vagal afferent r e s p o n s e s to e n d o g e n o u s CCK i n rat: electrophysiological evidence for high a n d low affinity CCK-A receptors a n d d e f i n i t i o n of vagal receptive fields. (Abstract# G4742) Y Li, JX Zhu and C Owyang. Ann Arbor, MI

3:30

S o m a t o s t a t i n a n a l o g u e octreotide i n h i b i t s r e t c h i n g to c i s p l a t i n i n a n e s t h e t i z e d ferrets. (Abstract# G4694) CL Gooch, FM Boissonade and D Grundy. Sheffield, United Kingdom

Motility and Nerve-Gut Interactions AGA Research Forum

2:15-3:45 p m

Chairs: Richard W. McCallum, William J. Snape COLONIC TRANSIT 2:15

Does t h e r e c t u m g e n e r a t e a p u s h i n g force d u r i n g defecation. (Abstract# G3386) SSC Rao, R Hatfield and J Leistikow. Iowa City, IA

2:30

Selectively e n h a n c e d p h a s i c b u t n o t t o n i c gastrocolonic c o n t r a c t i o n s i n d i a r r h e a p r e d o m i n a n t i r r i t a b l e bowel s y n d r o m e : role of s e r o t o n i n 5-HTs n e u r a l p a t h w a y s . (Abstract# G2986) E Bjornsson, WD Chey, F Hooper, M Woods, C Owyang and W Hasler. Ann Arbor, MI

2:45

Gastrocolonic r e s p o n s e to feeding a n d o t h e r "reflexes" i n p a t i e n t s w i t h complete lesions of the s p i n a l cord. (Abstract# G3267) U L~bbering, I Greving, C Monnerjahn, O Rommel, B May and P Enck. Bochum and Dfisseldorf, Germany

3:00

Dose-related effects of R093877, a b e n z o f u r a n e 5HT 4 agonist, on g a s t r o i n t e s t i n a l a n d colonic t r a n s i t i n health. (Abstract# G2999) EP Bouras, DD Burton, S McKinzie, AR Zinsmeister and M Camilleri. Rochester, MN

3:15

Lower vagal tone d u r i n g sleep i n w o m e n with i r r i t a b l e bowel s y n d r o m e . (Abstract# G3148) M Heitkemper, RL Burr, ME Jarrett, MK Lustyk and V Hertig. Seattle, WA

3:30

Subjective a n d objective sleep q u a l i t y i n i r r i t a b l e bowel s y n d r o m e . (Abstract# G3090) S Elsenbruch, M Harnish and W Orr. Oklahoma City, OK

Pancreatic Disorders AGA Research Forum

2:15-3:45 p m

Room 28 Ernest N. Morial Convention Center

Chairs: Charles D. Ulrich, II, Christopher E. Forsmark E X P E R I M E N T A L PANCREATITIS 2:15

P a n c r e a t i c stellate cells p r o d u c e collagen a n d other extracellular matrix proteins and exhibit a p r o l i f e r a t i v e r e s p o n s e to platelet-derived

g r o w t h factor. (Abstract# G1783) MV Apte, PS Haber, CS Moran, GW McCaughan, MA Korsten, RC Pirola and JS Wilson. Sydney, Australia and New York, NY 2:30

Kupffer cell blockade r e d u c e s h e p a t i c a n d systemic c y t o k i n e levels a n d l u n g i n j u r y i n h e m o r r h a g i c p a n c r e a t i t i s i n rats. (Abstract# G1880) B G100r, TA Blinman, DA Rigberg, KE Todd, JS Lane, JO Hines and HA Reber. Los Angeles, CA

Room 40 Ernest N. Morial Convention Center

GASTROENTEROLOGY VoL 114~No. 4

P174 PROGRAM OF THE ANNUAL MEETING

TUESDAY, MAY 19, 1998 Motility and Nerve-Gut Interactions AGA Research Forum 2:15-3:45 p m Room 44 Ernest N. Morial Convention Center

Chairs: Brenda B. Toner, Fernando Azpiroz

2:45

I n c r e a s e d e p i t h e l i a l cell t u r n o v e r i n a n t r u m a n d c o r p u s of H. pylori-infected s t o m a c h , i r r e s p e c t i v e of cagA s t a t u s . (Abstract# G0205) AM Abdalla, V Krivosheyev, Z Hanzely, PR Holt, Gi Perez-Perez, MJ Blaser and SF Moss. New York, NY and Nashville, TN

3:00

Fas-mediated apoptosis in autoimmune and Helicobaeter p~lori-associated g a s t r i t i s . (Abstract# G38U) MW Bennett, J O'C0nnell, GC O'Sullivan, JK Collins and F Shanahan. Cork, Ireland

3:15

H. pylori-induced g a s t r i c e p i t h e l i a l a p o p t o s i s is m e d i a t e d b y t h e CD95 (Fas) r e c e p t o r a n d l i g a n d system. (Abstract# GU15) J Rudi, D Kuck, Avon Herbay, PH Krammer, PR Galle and W Stremmel. Heidelberg, Germany

3:30

Helicobacter pylori and Apoptosis Sheila E. Crowe. Galveston, TX

IRRITABLE BOWEL AND PAIN PERCEPTION 2:15

2:30

2:45

3:00

3:15

3:30

Rectal and gastric hyperalgesia in children w i t h r e c u r r e n t a b d o m i n a l pain. (Abstract# G3069) C Di Lorenzo, L Sigurdsson, J Griffiths, L Scharff and A Wald. Pittsburgh, PA Visceral pain-associated disability syndrome i n a d o l e s c e n t s . (Abstract# G3065) K Devlin, L Schwankovsky, B Bursch, LK Zeltzer and PE Hyman. Orange and Los Angeles, CA Pain thresholds measured by the barostat p r e d i c t t h e s e v e r i t y of c l i n i c a l p a i n in p a t i e n t s w i t h i r r i t a b l e b o w e l s y n d r o m e . (Abstract# G3525) WE Whitehead, N Diamant, K Meyer, K Mikula, JB Hu, H Jia, S Bangdiwala, B Toner and D Drossman. Chapel Hill, NC and Toronto, Canada Altered cerebral evoked potentials and allodynia in patients with functional dyspepsia b y e l e c t r i c a l s t i m u l a t i o n of t h e e s o p h a g e a l m u c o s a . (Abstract# G3189) M Kanazawa, T N0mura, S Fukudo and M Hongo. Sendal, Japan A l t e r e d r e g i o n a l b r a i n a c t i v i t y to r e c t a l distention following repetitive sigmoid s t i m u l a t i o n i n IBS. (Abstract# G3326) B Naliboff, DHS Silverman, J Munakata, J Williams, MA Mandelkern, S Berman, M Schmulson, J Williams, S Gilmmore and EA Mayer. Los Angeles, CA L o n g t e r m s u c c e s s of b i o f e e d b a c k in paradoxical puborectalis contraction (anismus). (Abstract# G3185) P J0rnod, PH Wiesel, P Cuypers, M Herranz, G Dorta, J F Schnegg and AL Blum. Lausanne, Switzerland

Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum 2:15-3:45 p m Room 82 / 83 Ernest N. Morial Convention Center

Chairs: Jean E. Crabtree, Pierre F. Michetti I M M U N O P A T H O B I O L O G Y O F HELICOBACTER INFECTION 2:15

Differential a4~7-integrin a n d L-selectin h o m i n g r e c e p t o r e x p r e s s i o n d u r i n g n a t u r a l a n d vaccinei n d u c e d i m m u n e responses to H e l i c o b a c t e r infection in mice. (Abstract# G4255) M Michetti, CP Kelly and P Michetti. Boston, MA

2:30

Co-colonization a n d in vivo i n t e r a c t i o n b e t w e e n s t r a i n s of Helicobaeterpylori. (Abstract# G3973) KA Eaton, S Krakowka and DE Berg. Columbus, OH and St Louis, MO

2:45

D e t e r m i n a n t s of Helicobaeter pylori vacuolating cytotoxin production analyzed by c o n s t r u c t i o n of vacA h y b r i d s a n d b y sited i r e c t e d m u t a g e n e s i s . (Abstract# G4180) DP Letley, RJ Twells, BK Dove, CJ Hawkey, TL Cover and JC Atherton. Nottingham, United Kingdom and Nashville, TN

3:00

C e r t a i n TNF-~ m i c r o s a t e l l i t e alleles a r e a s s o c i a t e d w i t h d i f f e r e n t c o u r s e of Helicobaeterpylori infection. (Abstract# G4160) E Kunstmann, E Elitok, C Epplen, S Suerbaum, U Peitz, JT Epplen and W Schmiegel. Bochum and Magdeburg, Germany

3:15

The n e u t r o p h i l a c t i v a t i n g p r o t e i n of Hellcobacterpylori is a dps h o m o l o g u e without neutrophil activating properties. (Abstract# G4196) RPH Logan, GA Turner, D Thirwell, A Cockayne, P Jenks, CJ Hawkey and B Wren. Nottingham and London, United Kingdom

3:30

I m m u n o m o d u l a t i o n of Helicobaeter Jells c o l o n i z a t i o n of t h e m o u s e s t o m a c h . (Abstract# G3833) J B0, M Jordana, F Smaill, DP Snider, R Borojevic, D Steele-Norwood, RH Hunt and K Croitoru. Hamilton, Canada

Esophageal, Gastric, and Duodenal Disorders AGA Research Forum 2:15-3:45 p m Room 80/81 Ernest N. Morial Convention Center

Chairs: Steven J. Czinn, Peter B: Ernst HELICOBACTER P Y L O R I AND A P O P T O S I S 2:15

tt. pylori-induced G1 a r r e s t is a s s o c i a t e d w i t h s t i m u l a t i o n of c y c l i n E/cdk2 a n d p21. (Abstract# G0240) H Ashktorab, A Ahmed, G Littleton, R Tackey, CS Walters and DT Smoot. Washington, DC

2:30

tt. pylori i n d u c e s p 2 1 c i p l a n d i n h i b i t s G1/S progression while inducing apoptosis in s y n c h r o n i z e d g a s t r i c e p i t h e l i a l cells. (Abstract# GU80) H Shirin, S Oh, H Yamam0t0, EM Sordill0, T Delohery, PR Holt, IB Weinstein and SF Moss. New York, NY

II

A p r i l 1998

P R O G R A M O F T H E A N N U A L M E E T I N G P175

TUESDAY, MAY 19, 1998 Intestinal Disorders AGA Research Forum

2:15-3:45 p m

Room 95 / 96 Ernest N. Morial Convention Center

Chairs: Kim E. Barrett, Mark W. Musch REGULATION OF INTESTINAL ELECTROLYTE TRANSPORT

DDW Combined Clinical Symposium

4:00-5:30 p m

Room 9 0 / 9 1 / 9 2 Ernest N. Morial Convention Center

S p o n s o r e d by: ASGE/AGA/AASLD

Chairs: Lawrence J. Brandt, C. Melvin Wilcox HIV: GI M A N I F E S T A T I O N S

2:15

C r i t i c a l r o l e of cAMP r e s p o n s e e l e m e n t in h y p o x i a - i n d u c e d s e c r e t i o n of t u m o r n e c r o s i s factor-~ f r o m i n t e s t i n a l e p i t h e l i a l cells. (Abstract# G1723) CT Taylor and SP Colgan. Boston, MA

Attendees will learn about the role of endoscopic procedures in the evaluation of upper and lower GI symptoms in patients with HIV infection. In addition, attendees will learn about liver disease in AIDS, and the appropriate role of liver biopsy. Finally, attendees will be exposed to new information about nutritional issues in AIDS.

2:30

P r o t e i n k i n a s e A r e g u l a t e s ATP h y d r o l y s i s by t h e C F T R n b d l / R d o m a in . (Abstract# G1546) LD Howell, L Chien and JA Cohn. Durham, NC

4:00

2:45

R e g u l a t i o n of b a s o l a t e r a l p l a s m a m e m b r a n e r e c y c l i n g b y p r o t e i n k i n a s e C: role of F - act i n a n d MARCKS. (Abstract# G1703) JC Song, BJ Hrnjez, OC Farokzhad and JB Matthews. Boston, MA

3:00

3:15

3:30

G a l a n i n causes CI" s e c r e t i o n in T84 cells: i d e n t i f i c a t i o n of a n o v e l m e c h a n i s m for i n f e c t i o u s d i a r r h e a . (Abstract# G1612) JA Marrero, A Koutsouris, DA Ostrovskiy, SD Savkovic, G Hecht and RV Benya. Chicago, IL R e g u l a t o r y m e c h a n i s m s of cloned Na÷/H÷ e x c h a n g e r s i n v o l v e c h a n g e in t h e a m o u n t of p l a s m a m e m b r a n e e x c h a n g e r : use of cell s u r f a c e b i o t i n y l a t i o n . (Abstract# G1415) S Akhter, M Cavet, CM Tse and M Donowitz. Baltimore, MD Interferon-7 r e g u l a t e s e p i t h e l i a l c h l o r i d e s e c r e t i o n : r o l e of E G F r e c e p t o r - d e p e n d e n t p a t h w a y s . (Abstract# G1738) JM Uribe and KE Barrett. San Diego, CA

Gastrointestinal Pathology Society Companion Meeting

4:00-5:30 p m

Room 22/24 Ernest IV. Morial Convention Center

CONTROVERSIES IN GASTROINTESTINAL PATHOLOGY

4:15

When is u p p e r e n d o s c o p y i n d i c a t e d ? Loren A. Laine. Los Angeles, CA C o l o r e c t a l disease i n AIDS: H o w to find it. H o w to f i n d it. C. Melvin Wilcox. Birmingham, AL

What will be found. Lawrence J. Brandt. Bronx, NY 4:30

L i v e r b i o p s y in AIDS. D o it! Douglas T. Dieterich. Garden City, NJ

D o n 't do it! Scott L. Friedman. New York, NY 4:45

N u t r i t i o n in AIDS. PEG, P E J , or n o t h i n g . Mark Delegge. Charlotte, NC

5:00

Discussion.

DDW Combined Clinical Symposium

4:00-5:30 p m

Room 100 / 101 / 102 Ernest N. Morial Convention Center

S p o n s o r e d by: SSAT/AGA/AASLD/ASGE

Chairs: Jon S. Thompson, Jon A. Vanderhoof R E C E N T A D V A N C E S I N T H E T R E A T M E N T OF INTESTINAL FAILURE

I n f l a m m a t i o n a n d i n t e s t i n a l m e t a p l a s i a of t h e g a s t r i c corpus: Helieobaeterpylori, g a s t r o e s o p h a g e a l reflux, or both? John R. Goldbloom. Cleveland, OH

4:00

Introduction.

4:10

C u r r e n t s t a t u s of m e d i c a l t h e r a p y . Michael Farthing. London, England

G a s t r i c dysplasia: d i a g n o s t i c d i s c r e p a n c i e s w h e n East m e e t s West. Gregory Lauwers. Gainesville, FL

4:30

S t r a t e g i e s for l e n g t h e n i n g t h e i n t e s t i n e i n c h i l d r e n w i t h t h e s h o r t b o w e l syndr ome . Keith Georgeson. Birmingham, AL

D y s p l a s i a a n d u l c e r a t i v e colitis: is it a c o n v e n t i o n a l a d e n o m a o r a d a n g e r o u s DALM? Robert E. Petras. Cleveland, OH

4:50

C u r r e n t r o l e of i n t e s t i n a l t r a n s p l a n t a t i o n . Alan Langnas. Omaha, NE

5:10

Discussion.

GASTROENTEROLOGY Vo L 114~ No. 4

P176 PROGRAM OF THE ANNUAL MEETING

TUESDAY, MAY 19, 1998 AGA Clinical Symposium 4:00-5:30 p m Room 58 /59 / 60 Ernest N. Morial Convention Center

AGA R e s e a r c h S y m p o s i u m 4:00-5:30 p m Room 6 1 / 6 2 / 6 3 Ernest N. Morial Convention Center

Sponsored by Biliary Disorders Co-sponsored by Pancreatic Disorders

Co-sponsored b y PhD, MD/PhD, DVM Task Force, G a s t r o i n t e s t i n a l Oncology

Chairs: Eldon A. Shaffer, David Festi

Chairs: C. Richard Boland, Juanita L. Merchant

CONTROVERSIES IN BILIARY PANCREATITIS

CLINICAL ASPECTS OF COLON C A R C I N O G E N E S I S FOR THE BASIC SCIENTIST AND O P P O R T U N I T I E S FOR RESEARCH

Microlithiasis: What does it m e a n ? Sum P. Lee. Seattle, WA

4:00

Overview of clinically r e l a t e d p r o b l e m s i n n e e d of basic research. Juanita L. Merchant. Ann Arbor, MI

4:25

Genomic i n s t a b i l i t y a n d genetic p a t h w a y s to GI cancer. C. Richard Boland. La JoUa, CA

AGA C l i n i c a l S y m p o s i u m 4:00-5:30 p m Room 64 / 65 / 66 Ernest N. Morial Convention Center

4:50

Use of a n i m a l models to s t u d y genee n v i r o n m e n t a l i n t e r a c t i o n s i n GI c a n c e r Russell F. Jacoby. Madison, WI

Sponsored by Motility and Nerve-Gut Interactions Co-sponsored by Growth, Development, Nutrition and Intestinal Disorders

5:15

P a n e l Discussion

N o n v i s u a l i z e d stones: How to detect? Alan N. Barkun. Montreal, Canada W h e n to wait, scope, cut? David L. Carr-L0cke. Boston, MA Panel discussion

Chair:

Vera Loening-Baucke

Chronic Intestinal Psuedo-Obstruction, Carlo DiLorenzo. Pittsburgh, PA

Sponsored by Immunology, Microbiology, and Inflammatory Disorders Co-sponsored by Esophageal, Gastric, and Duodenal Disorders

Recurrent abdominal pain. John T. Boyle. Cleveland, OH

Chair:

F u n c t i o n a l c o n s t i p a t i o n a n d encopresis. Vera Loening-Baucke. Iowa City, IA

RECENT ADVANCES IN HELICOBACTER PYLORI PATHOGENESIS

G A S T R O I N T E S T I N A L DISORDERS IN CHILDREN

•

AGA Research Symposium 4:00-5:30 p m Room 85/86 Ernest N. Morial Convention Center

Cyclic vomiting. Bu K. Li. Columbus, OH

J. Thomas LaMont

Helicobacter pylori: A d a p t a t i o n a n d selection. Martin J. Blaser. Nashville, TN

AGA C l i n i c a l S y m p o s i u m 4:00-5:30 p m Room 89 Ernest N. Morial Convention Center

The gastric epithelial cell r e s p o n s e to Helicobacter pylori a t t a c h m e n t . Ciaran P. Kelly. Boston, MA

Sponsored by Clinical Practice Co-sponsored by Underrepresented Minorities

Helicobacter pylori i n f e c t i o n a n d g a s t r i c acid response. Kenneth E. McColl. Glasgow, Scotland

Chairs: John Carithers, Fred Nunes MINORITY H E A L T H I S S U E S IN GASTROENTEROLOGY: H E A L T H CARE U T I L I Z A T I O N AND H E P A T I T I S C IN T H E MINORITY COMMUNITY Race a n d g e n d e r t h r o u g h the l o o k i n g glass of h e a l t h care u t i l i z a t i o n . Laurence F. McMahon. Ann Arbor, MI H e p a t i t i s C: a g r o w i n g p r o b l e m i n t h e m i n o r i t y community. Lennox J. Jeffers. Miami, FL

April 1998

PROGRAM OF THE ANNUAL MEETING P177

TUESDAY, MAY 19, 1998 AGA Topic Forum

4:00-5:30 p m

4:45

F i n a l r e s u l t s of a p r o s p e c t i v e a n d r a n d o m i z e d trial e v a l u a t i n g endoscopic hemoclip for b l e e d i n g p e p t i c ulcer. (Abstract# Gl118) M S~bat, C Villanueva, J Ortiz, G Soriano, S S~inz, X Torras, X Cuss6, C Guarner and J Balanz6. Barcelona, Spain

5:00

M a i n t e n a n c e of H 2 - a n t a g o n i s t is n o t n e c e s s a r y after e r a d i c a t i o n of Helicobacterpylori i n b l e e d i n g p e p t i c ulcers. (Abstract# G0790) KC Lai, WM Hui, SK Lam, BCY Wong, KM Chu, WM Wong and WHC Hu. Hong Kong, China

5:15

Eradication of H. pyIoriversus m a i n t e n a n c e acid suppression to prevent r e c u r r e n t ulcer hemorrhage i n high risk NSAID users: a prospective randomized study. (Abstract# G0356) FKL Chan, JY Sung, R Suen, YT Lee, WK Leung, VKS Leung, JCY Wu and SCS Chung. Hong Kong, China

Room 37/38 Ernest N. Morial Convention Center

Chairs: James M. Scheiman, Jay L. Goldstein CLINICAL MYTHS REVISITED 4:00

C a l c i u m s u p p l e m e n t s do n o t cause c o n s t i p a t i o n . (Abstract# G0149) R Rothstein, E Konings, J Baron and the Polyp Prevention Study Group. Hanover, NH

4:15

R e b o u n d acid h y p e r s e c r e t i o n after gastric acid s u p p r e s s a n t t h e r a p y : a short-lived (<1 week) p h e n o m e n o n . (Abstract# G0052) RS Fisher, M Kushner, E Bonapace, LC Knight and HP Parkman. Philadelphia, PA

4:30

N u m b e r of Hemoccult w i n d o w s positively affects work-up. (Abstract# G0167) H Shields, M Weiner, D Henry, JA Lloyd, B Ransil, D Lamphier, D Antonioli and B Resner. Boston, MA

4:45

5:00

5:15

I n s u l i n r e s i s t a n c e ; a r i s k factor for gallstones? (Abstract# G0082) T Jcrgensen and K Borsh-Johnsen. Copenhagen, Denmark Use of a n e n t e r o s c o p e improves ability to p e r f o r m total colonoscopy i n p r e v i o u s l y u n s u c c e s s f u l a t t e m p t s at colonoscopy i n selected a d u l t p a t i e n t s . (Abstract# G0102) GR Lichtenstein, PD Park, WL Long, GG Ginsberg and ML Kochman. Philadelphia, PA P e r c u t a n e o u s endoscopic gastrostomy: the u n s e e n m o r t a l i t y . (Abstract# G0157) DS Sanders, MJ Carter, J D'Silva, G James, RP Bolton and KD Bardhan. Sheffield and Rotherham, United Kingdom

Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum

4:00-5:30 p m

Chairs: Bruce E. Sands, Stefan Schreiber I N S I G H T S INTO T H E R A P E U T I C M E C H A N I S M S IN IBD 4:00

Glucocorticoid r e c e p t o r ~ e x p r e s s i o n as a novel p r e d i c t o r for t h e r a p e u t i c efficacy of corticosteroid i n p a t i e n t s w i t h u l c e r a t i v e colitis. (Abstract# G3790) T Ayabe, S Imai, T Ashida, F Orii, T Fujiki, M Taniguchi, M Taruishi, Y Saitoh, T Obara and Y Kohgo. Asahikawa and Saitama, Japan

4:15

TNF-a s i g n a l i n g blockade b y a d o m i n a n t n e g a t i v e TRAP-2 delivered b y a d e n o v i r a l vector i n h i b i t s NF-KB a n d JNK a c t i v a t i o n a n d IL-8 e x p r e s s i o n in h u m a n i n t e s t i n a l epithelial cells. (Abstract# G4115) C Jobin, J-L Klein, C Brandham, K Streetz, DA Brenner and RB Sartor. Chapel Hill, NC

4:30

N e u t r a l i z a t i o n of e n d o g e n o u s t r a n s f o r m i n g growth factor-~l p r e v e n t s i n t e s t i n a l fibrosis. (Abstract# G4275) M Mourelle, F Guarner, J-R Malagelada, J Casalots and A Salas. Barcelona and Terrassa, Spain

4:45

A p55 t u m o r necrosis factor-~ receptor i m m u n o adhesin p r e v e n t s T cell m e d i a t e d intestinal i n j u r y by i n h i b i t i n g matrix metalloproteinase production. (Abstract# G4339) SLF Pender, JMC Fell, A Ashkenazi and TT MacDonald. San Francisco, CA and London, United Kingdom

5:00

R a p i d a n t i i n f l a m m a t o r y effect of high dose a z a t h i o p r i n e i n i n f l a m m a t o r y bowel disease: a n i n v/fro study. (Abstract# G4206) E Louis, P Dupont, A Depauw, F Croes, G Demolin and J Belaiche. Liege, Belgium

5:15

Constitutive mucosal multidrug resistance (PGP-170) e x p r e s s i o n c o r r e l a t e s with p e r i p h e r a l blood l y m p h o c y t e expression. (Abstract# G3991) RJ Farrell, A Murphy, A Long, PWN Keeling, DG Weir and D Kelleher. Dublin, Ireland and Boston, MA

Esophageal, Gastric, and Duodenal Disorders AGA Research Forum

4:00-5:30 p m

Ballroom A / B Ernest N. Morial Convention Center

Chairs: David J. Bjorkman, John G. Lee BLEEDING PEPTIC ULCER 4:00

4:15

4:30

P r e v a l e n c e of H. pylori a n d a s p i r i n or NSAID u t i l i z a t i o n i n p a t i e n t s with u l c e r h e m o r r h a g e : r e s u l t s of s c r e e n i n g for a large m u l t i c e n t e r U.S. trial. (Abstract# G0657) DM Jensen, ME Jensen, J King, J Gornbein, S Cheng and the CURE Hemostasis Research Group. Los Angeles, CA NSAIDS a n d CagA positive H. pylori b u t n o t CagA n e g a t i v e H. pylori as i n d e p e n d e n t r i s k factors for b l e e d i n g peptic ulcers. (Abstract# G1206) WA Stack, GM Hawkey, JC Atherton, G Pearson, S Everitt, K Fielding, RFA Logan and CJ Hawkey. Nottingham, United Kingdom

Diagnostic tests for H. pylori infection in acute u p p e r g a s t r o i n t e s t i n a l h e m o r r h a g e . (Abstract# G1296) N Vakil, AF Cutler, C Breitkreutz, A Affi and N Bethge. Milwaukee, WI; Detroit, MI and Berlin, Germany

Room 11 Ernest N. Morial Convention Center

G A S T R O E N T E R O L O G Y Vol. 114 r No. 4

P 1 7 8 P R O G R A M O F T H E A N N U A L MEETING

TUESDAY, MAY 19, 1998 Gastrointestinal Oncology AGA Research Forum

4:00-5:30 p m

4:45

Room 13 / 15 / 17 Ernest IV. Morial Convention Center

Chairs: Timothy C. Wang, Mark V. Larson

5:00

GASTRIC P R E N E O P L A S I A AND HELICOBACTER

PYLORI 4:00

CagA a n t i b o d i e s a n d s e r u m g a s t r i n as s c r e e n i n g tests for gastric p r e n e o p l a s t i c conditions. (Abstract# G2913) H Witherell, ML Sanchez, J Guarner, D Halperin, C Ley, A M0har and J Pars0nnet. Stanford, CA

4:15

P r e v a l e n c e of gastric i n t e s t i n a l m e t a p l a s i a a n d associated r i s k factors i n U.S. Hispanics. (Abstract# G2664) TG Morales, RE Sampliner, L Camarg0, S Marquis, HS Garewal and MB Fennerty. Tucson, AZ and Portland, OR M e t h y l e n e b l u e s t a i n i n g for the endoscopic diagnosis of i n t e s t i n a l m e t a p l a s i a i n the stomach. (Abstract# G2487) D Halperin, R Belmonte, L Sanchez, A Mohar, J Guarner, R Herrera and J Parsonnet. San Cristobal de las Casas and Mexico City, Mexico; Atlanta, GA and Stanford, CA I n t e s t i n a l m e t a p l a s i a i n the stomach: what h a p p e n s w h e n the p a t i e n t is followed with r e p e a t e d t a r g e t e d biopsies? (Abstract# G0467) HMT E1-Zimaity and DY Graham. Houston, TX

4:30

4:45

5:00

Gastric m u c o s a l a t r o p h y is a s t r o n g p r e d i c t o r of n o n - c a r d i a gastric c a n c e r b u t n o t of cardia cancer. (Abstract# G2493) S Hansen, SE Vollset, K Melby, S Aase, E Jellun, V Fyfe, J Ferguson and KEL McColl. Oslo, Bergen and Trondenheim, Norway; Glasgow, Scotland

5:15

P r e v a l e n c e of a t r o p h y a n d h y p o c h l o r h y d r i a is h i g h i n gastric c a n c e r relatives a n d r e l a t e d to H. pylori status. (Abstract# G2419) E E1-Omar, K Oien, A E1-Nujumi, A Wirz, D Gillen, C Williams, JES Ardill, G Fullarton and KEL McColl. Glasgow, Scotland

Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum

4:00-5:30 p m

Room 19 Ernest IV. Morial Convention Center

5:15

Motility a n d Nerve-Gut I n t e r a c t i o n s AGA Research Forum

4:00-5:30 p m

4:00

4:15

4:30

I n d u c i b l e n i t r i c oxide s y n t h a s e activity is p r o t e c t i v e i n t h e enterocolitis of IL-10 k n o c k o u t mice. (Abstract# G4529) GW Varilek, F Yang, KS Ramanujam, WJS de Villiers and KT Wilson. Lexington, KY and Baltimore, MD IL-10 r e g u l a t e s a u t o r e a c t i v e T cell activity i n colitis-prone mice. (Abstract# G4108) K Ito and PB Ernst. Galveston, TX E p i t h e l i a l c y t o p r o t e c t i o n is p a r t of the t h e r a p e u t i c effect of i n t e r l e u k i n - 1 0 i n mucosal i n f l a m m a t i o n . (Abstract# G4291) K Nally, F Newton, J O'ConneU, J Morgan, GC O'Sullivan, JK Collins and F Shanahan. Cork, Ireland

Room 28 Ernest N. Morial Convention Center

Chairs: Juan R. Malagelada, Eamonn M.M. Quigley FAT, GLUCOSE AND MOTILITY 4:00

Gastric e m p t y i n g of a low fat meal. E s t a b l i s h m e n t of i n t e r n a t i o n a l c o n t r o l values. (Abstract# G3113) G Tougas. Hamilton, Canada; Kansas City, KS; Omaha, NB; Oklahoma City, OK; Memphis, TN; Gothenburg, Sweden; Tampa, FL; Hershey, PA; New York, NY; Bologna, Italy and Maastricht, The Netherlands

4:15

Gastric a c c o m m o d a t i o n a n d p e r c e p t i o n : c o n t r o l via n u t r i e n t - s p e c i f i c i n t e s t i n a l afferents. (Abstract# G3021) M Carrasco, F Azpir0z and J-R Malagelada. Barcelona, Spain

4:30

Meal composition affects the n u m b e r a n d o r g a n i z a t i o n of d u o d e n a l a n d j e j u n a l p r e s s u r e waves. (Abstract# G3407) M Samsom, R Fraser, MAMT Verhagen, K Adachi, AJPM Sm0ut, M Horowitz and J Dent. Utrecht, The Netherlands and Adelaide, Australia

4:45

F a t - i n d u c e d ileal b r a k e d e p e n d s o n cholecystokinin. (Abstract# G3252) HC Lin, XT Zhao and LJ Wang. Los Angeles, CA

5:00

I d e n t i f i c a t i o n a n d c h a r a c t e r i z a t i o n of glucoresponsive n e u r o n s i n the r a t small i n t e s t i n e . (Abstract# G3204) A Kirchgessner and M-T Liu. New York, NY

5:15

A b d o m i n a l symptoms, d i s t e n s i o n a n d i n t e s t i n a l gas r e t e n t i o n i n d u c e d b y lipids. (Abstract# G3430) J Serra, F Azpiroz and J-R Malagelada. Barcelona, Spain

Chairs: Peter B. Ernst, Charles O. Elson MUCOSAL I M M U N I T Y AND INFLAMMATION: IL-10

I n t e r l e u k i n - 1 0 s t i m u l a t e s s o m a t o s t a t i n gene e x p r e s s i o n in vitro a n d i n vivo. (Abstract# G4U3) P Jiang, H Wasserstrom, S Mehta, J Lawler, J Morton, A FranceUa and MW Babyatsky. New York, NY Severe, e a r l y colitis i n C3H/HeJBir-IL-10 deficient mice. (Abstract# G3865) IJ Bristol, M M~hler, JP Sundberg, EH Leiter, Y Cong and CO Elson. Bar Harbor, ME and Birmingham, AL Local p r o d u c t i o n of IL-12 by l a m i n a p r o p r i a m o n o n u c l e a r cells is t r i g g e r e d w i t h t h e onset of colitis a n d subsides d u r i n g c h r o n i c disease. (Abstract# G4459) DM Spencer and AD Levine. Cleveland, OH

A p r i l 1998

P R O G R A M O F T H E A N N U A L M E E T I N G P179

TUESDAY, MAY 19, 1998 Hormones, Transmitters, Growth Factors and Their Receptors AGA Research Forum

4:00-5:30 p m

Room 33/35 Ernest N. Morial Convention Center

4:45

F o r m e fruste cystic fibrosis p r e s e n t i n g as p a n c r e a t i t i s i n adults. (Abstract# G1839) TK Desai, M Linerode and N Siddiqu. Royal Oak, MI

5:00

Molecular c o n s e q u e n c e s of CFTR gene m u t a t i o n s i n the e x o c r i n e p a n c r e a s . (Abstract# G1779) N Ahmed, M Corey, J Zielenski, L-C Tsui, L Ellis, E Tullis and P Durie. Toronto, Canada

5:15

I m p a i r e d CI'/HCO 3" e x c h a n g e r activity, associated with defective CI" c o n d u c t a n c e , can be r e s t o r e d b y p u r i n e r g i c s t i m u l a t i o n i n a cystic fibrosis p a n c r e a t i c duct cell line (CFPAC-1). (Abstract# G2092) ,~ Zsembery, M Strazzabosco and J Graf. Vienna, Austria and Padua, Italy

Chairs: Travis E. Solomon, John R. Grider, Jr. PHYSIOLOGY/CELL BIOLOGY 4:00

G13-mediated a c t i v a t i o n of PLD i n d u c e s t r a n s l o c a t i o n of PKC-c a n d s u s t a i n e d muscle c o n t r a c t i o n . (Abstract# G4774) KS Murthy and GM Makhlouf. Richmond, VA

4:15

VIP-induced, G p r o t e i n - d e p e n d e n t a c t i v a t i o n of eNOS i n COS-1 cells co-transfected with eNOS a n d n a t r i u r e t i c p e p t i d e clearance receptor. (Abstract# G4844) B-Q Teng, KS Murthy and GM Makhlouf. Richmond, VA

4:30

4:45

P h a r m a c o l o g y a n d i n t r a c e l l u l a r s i g n a l i n g of t h e h u m a n b o m b e s i n r e c e p t o r s u b t y p e 3. (Abstract# G4812) RR Ryan, HC Weber, SA Mantey, TK Pradhan, W Hou, DH Coy and RT Jensen. Bethesda, MD and New Orleans, LA The c h o l e c y s t o k i n i n type B r e c e p t o r i n the h u m a n kidney mediates gastrin-stimulated u r i n a r y s o d i u m excretion. (Abstract# G4797) JR Pisegna, EA Lew, NI Tarasova, JA Kopp, CJ Michejda, JH Walsh and SA Wank. Los Angeles, CA and Bethesda, MD

5:00

C o m p a r i s o n of s y n t h e t i c r a t CCK-58 a n d CCK-8 r e v e a l s d i s s o c i a t i o n of p a n c r e a t i c fluid a n d e n z y m e s e c r e t i o n a n d g r e a t e r p o t e n c y of CCK58 i n vivo. (Abstract# G4801) JR Reeve, Jr, P Gong, T C0skun, Y Zong, FJ H0 and TE Solomon. Los Angeles, CA

5:15

Leptide, a r a t l e p t i n r e c e p t o r antagonist, is a r a p i d a n d p o t e n t s t i m u l a t o r of i n s u l i n s e c r e t i o n i n vivo. (Abstract# G3626) MS Jasper, T Gulick, P Davis and LM Kaplan. Boston, MA

Pancreatic Disorders AGA Research Forum

4:00-5:30 p m

Motility and Nerve-Gut Interactions AGA Research Forum

4:00-5:30 p m

Chairs: Douglas A. Drossman, Nicholas J. Talley IBS: EVALUATION OF T R E A T M E N T AND MANAGEMENT 4:00

The r e f r a c t o r y f u n c t i o n a l GI p a t i e n t : d e f i n i t i o n a n d i m p l i c a t i o n s for cost effective care. (Abstract# G3343) KW Olden and SS Hom. San Francisco, CA

4:15

Alosetron, a 5 H T 3 r e c e p t o r a n t a g o n i s t , is effective i n the t r e a t m e n t of female i r r i t a b l e bowel s y n d r o m e p a t i e n t s . (Abstract# G3336) AR Northcutt, M Camilleri, EA Mayer, DA Drossman, GE Dukes, RSB Ehsanullah, LR Hamm, JP Harding, AT Heath, L Jacques, S Wolfe, S Kong, D McSorley and AW Mangel. Research Triangle Park and Chapel Hill, NC; Rochester, MN and Los Angeles, CA

4:30

A c o m p a r i s o n of t h e Rome a n d M a n n i n g c r i t e r i a i n i d e n t i f y i n g i n d i v i d u a l s w i t h the i r r i t a b l e bowel s y n d r o m e . (Abstract# G3405) YA Saito, GR Locke, III, NJ Talley, AR Zinsmeister and LJ Melton, III. Rochester, MN

4:45

M a n n i n g c r i t e r i a a n d Rome c r i t e r i a i n the diagnosis of i r r i t a b l e bowel s y n d r o m e : a comparison between a population based study a n d a selected p a t i e n t s p o p u l a t i o n . (Abstract# G3230) F Laterza, M Neri, F Romano, M Ricciuti, F Carbone, F Schioppa, F Bazzoli, E Roda, G Mazzella, D Panuccio and D Festi. Chieti, Bologna and Loiano, Italy

5:00

I n a c c u r a t e k n o w l e d g e a n d poor u n d e r s t a n d i n g of the i r r i t a b l e bowel s y n d r o m e m a y i n f l u e n c e c o n s u l t a t i o n b e h a v i o r a n d illness a t t i t u d e s . C a n p a t i e n t s a n d the m e d i a be b e t t e r educated? (Abstract# G3418) S Scheuner, JE Gomborone, Z Mahmood and LJD O'Donnell. Castlebar, Ireland and London, United Kingdom

5:15

Educational needs in patients with irritable bowel s y n d r o m e - i m p l i c a t i o n s for clinical m a n a g e m e n t . (Abstract# G3351) M O'Sullivan, N Mahmud, D Kelleher, E Lovett and CA O'Morain. Dublin, Ireland

Room 40 Ernest N. Morial Convention Center

Chairs: Steven D. Freedman, Jeremy S. Wilson CYSTIC F I B R O S I S AND T H E PANCREAS 4:00

Cystic fibrosis m a y be explained b y a p r i m a r y defect i n f a t t y acid metabolism. (Abstract# G1864) SD Freedman, MH Katz, EM Parker, M Laposata, MY Urman and JG Alvarez. Boston, MA

4:15

CFTR m u t a t i o n s a n d IVS8-5T p r e v a l e n c e i n i d i o p a t h i c c h r o n i c a n d acute r e c u r r e n t p a n c r e a t i t i s . (Abstract# G1811) C Castellani, D Sgarbi, G Cavallini, V Di Francesco, P Bovo, L Frulloni, B Vaona, A Bonizzato, C Bassi, M Falconi, P Pederzoli and G Mastella. Verona, Italy

4:30

U p r e g n l a t i o n of p l a s m a m e m b r a n e CFTR e x p r e s s i o n i n AF508 cells b y b u t y r a t e a n d low t e m p e r a t u r e . (Abstract# G1904) GD Heda, V Rose and CR Marino. Memphis, TN

Room 80/81 Ernest N. Morial Convention Center

P180 P R O G R A M O F T H E A N N U A L M E E T I N G

G A S T R O E N T E R O L O G Y Vol. 114~ No. 4

TUESDAY, MAY 19, 1998 Gastrointestinal Oncology AGA Research Forum

4:00-5:30 p m

Room 93/94 Ernest N. Morial Convention Center

4:45

5:00

Chairs: R. Daniel Beauchamp, Steven M. Powell G R O W T H FACTORS, GROWTH FACTOR R E C E P T O R S AND CANCER 4:00

I n d u c t i o n of r e t i n o i c acid r e c e p t o r ~ mediates growth inhibition in retinoid resistant human colon c a r c i n o m a cells. (Abstract# G2696) B Nicke, E-O Riecken and S Rosewicz. Berlin, Germany

4:15

The i n s u l i n - l i k e g r o w t h factor-II receptor: a p o t e n t i a l g r o w t h s u p p r e s s o r gene i n colorectal c a r c i n o m a cells. (Abstract# G2820) RF Souza, S Wang, K Sm01inski, J Yin, T-T Z0u, D Kong, JM Abraham, WS Sly and SJ Meltzer. Baltimore, MD and St Louis, Mo E x o c r i n e p a n c r e a t i c cells express a novel family of KRAB/ID zinc f i n g e r t r a n s c r i p t i o n a l repressors involved in growth regulation. (Abstract# G2464) B Gebelein, MF Zapico and R Urrutia. Rochester, MN I d e n t i f i c a t i o n of TGF-~ t a r g e t genes i n p a n c r e a t i c c a n c e r cells b y CDNA r e p r e s e n t a t i o n a l difference analysis. (Abstract# G2465) MM Geng, G Adler and TM Gress. Ulm, Germany

4:30

4:45

5:00

5:15

I n t e s t i n a l trefoil factor (ITF) gene expression is i n h i b i t e d b y s h o r t c h a i n fatty acids i n a colon c a n c e r cell l i n e a n d m a y be m e d i a t e d b y a specific r e s p o n s e e l e m e n t i n the ITF p r o m o t e r . (Abstract# G2860) CP Tran, M Familari, RH Whitehead and AS Giraud. Melbourne, Australia Association of a n a b b e r r a n t spasmolytic p e p t i d e - e x p r e s s i n g cell l i n e a g e w i t h gastric a d e n o c a r c i n o m a i n h u m a n s . (Abstract# G2781) PH Schmidt, JR Lee, JR G01denring, NA Wright and R Poulsom. Augusta, GA and London, United Kingdom

5:15

Room 95/96 Ernest N. Morial Convention Center

4:00-5:30 p m

4:00

4:15

4:30

A m m o n i a i n h i b i t s r e g u l a t e d chloride secretion i n in vitro h u m a n colon. (Abstract# S0185) TC O'Brien, M Riegler, EC Mun, M Prasad, C Pothoulakis and JB Matthews. Boston, MA R e g u l a t i o n of i n t e s t i n a l e p i t h e l i a l Na-K-2CI c o t r a n s p o r t e r e x p r e s s i o n b y p r o t e i n k i n a s e C. (Abstract# G1502) OC Farokzhad, EC Mun, JA Smith, JK Sicklick, JC Song and JB Matthews. Boston, MA PKA type II m e d i a t e s NHE3 i n h i b i t i o n b y c h a n g e of the pH, d e p e n d e n c y : t h e role of E3KARP a n d NHERF. (Abstract# G1593) G Lamprecht, A Bretscher, EJ Weinman and CHC Yun. Baltimore, MD and Ithaca, NY

Room 97/98 Ernest N. Morial Convention Center

Chairs: Andrew B. Leiter, Saul Karpen TRANSCRIPTIONAL R E G U L A T I O N OF G U T GENE EXPRESSION 4:00

The g u t - e n r i c h e d Kriippel-like factor suppresses t h e p r o m o t e r a c t i v i t y of t h e cytochrome P450 1A1 gene i n a s p l - d e p e n d e n t fashion. (Abstract# G3755) WQ Zhang, JM Shields and VW Yang. Baltimore, MD

4:15

PAX4 is r e q u i r e d for d i f f e r e n t i a t i o n of p e p t i d e YY cells i n mouse colon. (Abstract# G3738) V Udupi, S Rajaraman, B West, P Grnss, L StOnge and GH Greeley, Jr. Galveston, TX and G6ttingen, Germany

4:30

Role of the h o m e o b o x gene H / x i n m o u s e g a s t r o i n t e s t i n a l a n d liver d e v e l o p m e n t : p r o m o t e r a n d d o w n s t r e a m t a r g e t analysis. (Abstract# G3551) MD Bates, DP Witte, RP Harvey and SS Potter. Cincinnati, OH and Victoria, Australia

4:45

T r a n s a c t i v a t i o n b y t h e g u t - e n r i c h e d Kriippellike factor d e p e n d s o n acidic a m i n o acid residues and on protein-protein interaction. (Abstract# G3607) DE Geiman, H Ton-That, JM Shields and VW Yang. Baltimore, MD

5:00

T r a n s c r i p t i o n a l r e g u l a t i o n of t h e DRA gene: a model for the a l t e r a t i o n of d i f f e r e n t i a t e d gene expression i n i n t e s t i n a l pathobiology. (Abstract# G1556) W Jiang and GD Wu. Philadelphia, PA

5:15

Transcriptional regulation by hepatocyte n u c l e a r factor 4 is critical for i n t e s t i n a l expression of g u a n y l y l cyclase. (Abstract# G3729) ES Swanson, EA Mann, ML Jump and RA Giannella. Cincinnati, OH

Chairs: Jeffrey E. Matthews, Marshall H. Montrose, III CELLULAR M E C H A N I S M S OF I N T E S T I N A L ELECTROLYTE TRANSPORT

O n t o g e n y of cGMP s t i m u l a t e d c h l o r i d e t r a n s p o r t i n r a b b i t colon. (Abstract# G1636) S Nataraja, J Benkatasubramanian, D Bidyasagar and MC Rao. Chicago, IL

Growth, Development, Nutrition AGA Research Forum

Intestinal Disorders AGA Research Forum

4:00-5:30 p m

R e g u l a t i o n of r a t ileal NHE3 b y 1,25(OH) 2 v i t a m i n D~. (Abstract# G1637) TM Nazir, S Tyagi, R Wall, M Sitrin, TA Brasitus, K Ramaswamy and PK Dudeja. Chicago, IL I n h i b i t i o n of i n t e s t i n a l e p i t h e l i a l Na÷-H+ exchange r e s u l t s i n i n c r e a s e d t r a n s e p i t h e l i a l resistance and decreased myosin light chain p h o s p h o r y l a t i o n . (Abstract# G1734) JR Turner, ED Black, JM Angle, H Alli and JL Madara. Detroit, MI and Atlanta, GA

A p r i l 1998

P R O G R A M O F T H E A N N U A L M E E T I N G P181

TUESDAY, MAY 19, 1998 Esophageal, Gastric, and Duodenal Disorders AGA Research Forum

4:00-5:30 p m

Room 99 Ernest N. Morial Convention Center

Chairs: John W. Harmon, Adhip N. Majumdar MUCOSAL D E F E N S E AND REPAIR: GROWTH FACTORS AND A N G I O G E N E S I S 4:00

Mucosal r e p a i r a n d u l c e r h e a l i n g - role of g r o w t h factors a n d angiogenesis. Andrzej Tarnawski. Long Beach, CA

4:15

V a s c u l a r e n d o t h e l i a l g r o w t h factor e n h a n c e s a n g i o g e n e s i s i n i n j u r e d gastric mucosa a n d accelerates h e a l i n g of e t h a n o l i n d u c e d erosions. (Abstract# G1258) A Tarnawski, S Sekhon, Y Ichikawa and IJ Sarfeh. Long Beach and Irvine, CA

4:30

Differential e x p r e s s i o n of EGF r e c e p t o r d u r i n g the e a r l y gastric m u c o s a l r e p a r a t i v e p h a s e b e t w e e n y o u n g a n d aged rats. (Abstract# G0841) L Liu, J Turner, Y Yu, A Khan, SEG Fligiel and APN Majumdar. Detroit, MI

4:45

C h a n g e s i n t r a n s c r i p t i o n factors Egr-I a n d Sp1 e x p r e s s i o n i n the e a r l y stages of cysteaminei n d u c e d d u o d e n a l u l c e r a t i o n . (Abstract# G0217) J A1-Bassam, S Szabo, Z Sand0r and G Singh. Long Beach and Irvine, CA

5:00

H. pyloriVacA cytotoxin interferes with the Rho/Rac-1 s i g n a l cascade i n w o u n d e d gastric e p i t h e l i a l m o n o l a y e r s : a key to i n h i b i t i o n of ree p i t h e l i a l i z a t i o n . (Abstract# G1035) R Pai, E Sasaki, FA Wyle, M Domek and A Tarnawski. Long Beach and Irvine, CA

5:15

The i m p o r t a n c e of IL-I~-PG-HGF p a t h w a y i n t h e r e p a i r process of gastric mucosa. (Abstract# G0258) H Bamba, S Ota, A Kato and F Matsuzaki. Saitama, Japan

AGA Section Business Meetings

5:30-6:30 p m

Ernest IV. Morial Convention Center Members only

Immunology, Microbiology, a n d I n f l a m m a t o r y Disorders Clinical P r a c t i c e P a n c r e a t i c Disorders B i l i a r y Disorders G a s t r o i n t e s t i n a l Oncology Growth, Development, N u t r i t i o n

Room 19 Room 37 Room 40 Room 58/59/60 Room 93/94 Room 97/98

G A S T R O E N T E R O L O G Y Vol. 114~ N o . 4

P182 P R O G R A M O F T H E A N N U A L M E E T I N G

WEDNESDAY, MAY 20, 1998

II

AMERICAN SOCIETY FOR GASTROINTESTINAL ENDOSCOPY T h e D i s t i n g u i s h e d Service A w a r d . Presented to: Michael Obsfeldt and Mark Donahue. Huntington, NY

ASGE Annual Business Meeting 7:15 am Ballroom C Ernest N. Morial Convention Center 9:30

A c c u r a c y of p a t h o l o g i c i n t e r p r e t a t i o n of colon p o l y p s b y g e n e r a l p a t h o l o g i s t s . (Abstract# 281) M Alikhan, D Rex, 0 Cummings and T Ulbright. Indianapolis, IN

9:40

Routine versus as needed sedation for c o l o n o s c o p y i n self.selected A m e r i c a n s . (Abstract# 133) D Rex and VL Portish. Indianapolis, IN

I n t r o d u c t i o n a n d Welcome.

9:50

Q u e s t i o n s a n d Answers.

ASGE/BARD F e l l o w P r i z e M a n u s c r i p t A w a r d .

10:00

The ASGE S c h i n d l e r A w a r d . Introduced by: Melvin Schapiro. Los Angeles, CA Presented to: John H. Bond. Minneapolis, MN

10:10

Success a n d c o m p l i c a t i o n s of d i a g n o s t i c ERCP i n c h i l d r e n . (Abstract# 152) M Guelrud, D Ja~n, C Morera, JG Prados and M Colucci. Caracas, Venezuela

10:20

F a i l u r e s a n d c o m p l i c a t i o n s of a t t e m p t e d t h e r a p e u t i c ERCP: i m p a c t o n o u t c o m e s a n d costs. (Abstract# 360) ML Freeman, DB Nelson, GM Eisen, JA DiSario, HW Snady, CS Overby, RV Erickson, ME Ryan, GS Bochna, MJ Shaw, JP Moore, MB Fennerty, JG Lee, AM Pheley and the ERCP Outcome Study Group. Minneapolis, MN

10:30

Q u e s t i o n s a n d Answers.

10:40

Distinguished Lecture Upper gastrointestinal hemorrhage: progress in research, training and outcomes. Dennis M. Jensen. Los Angeles, CA

ASGE Plenary Session 8:00 am-12:00 p m Ballroom C Ernest N. Morial Convention Center

Chairs: Richard A. Kozarek, H. Juergen Nord 8:00

ASGE A s t r a M e r c k Y o u n g I n v e s t i g a t o r s ' A w a r d Winners. ASGE O l y m p u s A d v a n c e d E n d o s c o p i c Research Fellowships. Presented to: Ian D. Norton. Rochester, MN Michael B. Wallace. Boston, MA ASGE Wilson-Cook A d v a n c e d E n d o s c o p i c Research Scholarship. Presented to: TBA ASGE E d u c a t i o n a l A w a r d of Merit. Presented to: Boston Scientific/Microvasive 8:10

Endoscopy-based triage significantly reduces h o s p i t a l i z a t i o n r a t e s a n d costs of t r e a t i n g u p p e r GI b l e e d i n g : a r a n d o m i z e d c o n t r o l l e d t r i a l . (Abstract# 120) JG Lee, S Turnipseed, N Melnikoff, R Hsu, D Kirk, JW Leung, H Vigil, J Rose and R Sokolove. Sacramento, CA

8:20

Effectiveness of a p r o t o c o l - b a s e d t e a m a p p r o a c h to g a s t r o i n t e s t i n a l h e m o r r h a g e . (Abstract# 273) PD Stevens, DE Milkes, S Goodman, J Finegold, CJ Lightdale, RJ Garcia-Carrasquillo, PHR Green, F Meyer, R Rosenberg, SK Lewis, M Rubin and L Schneider. New York, NY

11:00

P h a s e I c l i n i c a l t r i a l of local i m m u n o t h e r a p y (cytoimplant) d e l i v e r e d b y e n d o s c o p i c u l t r a s o u n d - g u i d e d fine n e e d l e i n j e c t i o n i n patients with advanced pancreatic carcinoma. (Abstract# 480) KJ Chang, PT Nguyen, JA Thompson, TT Kurosaki, LR Casey and EC Leung. Orange, CA

8:30

Questions and Answers.

11:10

8:40

R e p e a t e n d o s c o p i c t r e a t m e n t o r s u r g e r y in t h e m a n a g e m e n t of p a t i e n t s w i t h r e h l e e d i n g peptic ulcers after initial endoscopic hemostasis: a prospective randomized c o n t r o l l e d t r i a l . (Abstract# 250) JYW Lau, JJY Sung, ACW Chan, EKW Ng, FKL Chan, RCY Suen and SCS Chung. Shatin, Hong Kong

EUS as a n a i d to clinical d e c i s i o n m a k i n g for referring physicians: what does it add when a CT s c a n is s u s p i c i o n s for p a n c r e a t i c c a n c e r ? (Abstract# 521) AV Sahai, D Williams, I Penman, G Mishra, W Knapple, P Baron, A vanVelse, RI-I Hawes and BJ Hoffman. Charleston, SC

11"20

Questions a n d Answers.

11:30

Outcomes of p a n c r e a t i c t h e r a p e u t i c ERCP as c o m p a r e d w i t h b i l i a r y t h e r a p e u t i c a n d d i a g n o s t i c ERCP: a p r o s p e c t i v e m u l t i s i t e study. (Abstract# 449) ML Freeman, DB Nelson, JA DiSario, CS Overby, RV Erickson, ME Ryan, GS Bochna, MJ Shaw, JP Moore, HW Snady, MB Fennerty, JG Lee, AM Pheley and the ERCP Outcome Study Group. Minneapolis, MN

11:40

EASIE - E r l a n g e n Active S i m u l a t o r for I n t e r ventional Endoscopy - a new biosimulation model: f i r s t e x p e r i e n c e s g a i n e d i n t r a i n i n g w o r k s h o p s . (Abstract# 370) J Hochberger, M Neumann, J Maiss, W Hohenberger and EG Hahn. Erlangen, Germany

11:50

Questions a n d Answers.

8:50

I n t r a s p h i n c t e r i c i n j e c t i o n of b o t u l i n u m t o x i n A versus balloon dilation in patients with achalasia. A randomized prospective c o m p a r a t i v e t r i a l . (Abstract# 199) SM Muehldorfer, T Schneider, J Hochberger, EG Hahn and C Ell. Erlangen and Wiesbaden, Germany

9:00

Questions and Answers.

9:10

Presidential Address I f I r a n t h e circus... Richard A. Kozarek. Seattle, WA

A p r i l 1998

P R O G R A M O F T H E A N N U A L M E E T I N G P183

WEDNESDAY, MAY 20, 1998 ASGE Clinical Symposium 2:15-3:45 p m Room 93/94 Ernest N. Morial Convention Center

Chair:

Louis Y. Korman

MULTI-MEDIA-

2:54

MJ Slepian, MS Mokhashi, B Dehdashti and RE Sampliner. Tucson, AZ

3:07

ENDOSCOPIC RECORD

Attendees will learn about the development of a standard lexicon for endoscopic reporting, and the development of networks for endoscopic reporting and imaging.

P o l y m e r i c e n d o e s o p h a g e a l paving: a biodegradable alternative to stenting. (Abstract# 59)

Water jet propelled colonoscopy: a n e w m e t h o d of e n d o s c o p e propulsion. (Abstract# 64) CP Swain, CA Mosse, GD Bell and TN Mills. London, United Kingdom

3:20

State of the A r t L e c t u r e . David L. Carr-L0cke. Boston, MA

Report and i m a g e standards. Louis Y. Korman. Washington, DC

M i n i m u m standard terminology: I.I.S. experience w i t h standard lexicon.

ASGE Clinical Symposium 2:15-3:45 p m Room 100 / 101 / 102 Ernest N. Morial Convention Center

Oliver W. Cass. North Oaks, MN Th e GASTER Project: creation of a digital i m a g i n g

n e t w o r k in Europe. Michel M. Delvaux. Toulouse, France Th e CORI Project: o u t c o m e s r e s e a r c h using a computerized endoscopic report. David A. Lieberman. Portland, OR

Chairs: Wilfred M. Weinstein, Marcia I. Canto VITAL S T A I N I N G / C H E M O E N D O S C O P Y New advances in endoscopic staining of GI pathology will be presented. Attendees will learn about the possible role of these new methods in the identification of early malignant lesions in the GI tract.

Panel d i s c u s s i o n and questions. History and principles of vital staining. Charles J. Lightdale. New York, NY

ASGE Topic Forum 2:15-3:45 p m Room 61 / 62 / 63 Ernest N. Morial Convention Center

Lugol's and toluidine blue staining of the esophagus (squamous cell carcinoma).

Chairs: Michael V. Sivak, Jr., Hiroaki Suzuki

Methylene blue s t a i n i n g (Barrett's esophagus).

David E. Fleischer. Washington, DC

N E W T E C H N O L O G Y IN E N D O S C O P I C P R A C T I C E In this session, attendees will learn about new endoscopic advances in the diagnosis of Barrett's esophagus. Attendees will learn new information about endoscopic cryospray, an innovative application of biodegradable structural polymers in the GI tract, and the development of a water-jet propelled colonoscope. New innovations will be placed into perspective in the state of the art address.

2:15

P h o t o d y n a m i c diagnosis of high-grade dysplasia and early cancer in the upper GI tract u s i n g 5-aminolevulinic acid. (Abstract# 20) L Gossner, H Stepp, R Sroka, A May, M Stolte and C Ell. Wiesbaden and Bayreuth, Germany

2:28

P h o t o d y n a m i c diagnosis of dysplasia in Barrett's e s o p h a g u s after sensitization w i t h 5-amino levulinic acid. (Abstract# 194) H Messmann, R Knfichel, E Endlicher, T Hauser, F Kullmann and J SchSlmerich. Regensburg, Germany

2:41

A second-generation endoscopic cryospray: e x p e r i m e n t a l results and first clinical use. (Abstract# 46) PJ Pasricha, S Hill, KS Wadwa, GT Gislason, PI Okolo, III, CA Magee, J Baust, WH Kuo and AN Kalloo. Galveston, TX; Binghamton, NY and Baltimore, MD

Marcia I. Canto. Baltimore, MD

Indigo carmine and cresyl violet s t a i n i n g (early colorectal cancer). Shinei Kudoh. Akita, Japan

Panel discussion and questions. ASGE Clinical Symposium 4:00-5:30 p m Room 100 / 101 / 102 Ernest N. Morial Convention Center

Chairs: Glen A. Lehman, Richard A. Kozarek E N D O T H E R A P Y OF P A N C R E A T I C D I S E A S E Attendees will learn about the role of ERCP in the diagnosis and management of gallstone pancreatitis and treatment of pancreatic disease, including pseudocysts, disrupted ducts and strictures.

Gallstone pancreatitis: timing, yield and need for ERCP. David L. Carr-Locke. Boston, MA

Obstructed pancreatic ducts - t h e r a p y of stones, strictures and sphincter disease. Stuart Sherman. Indianapolis, IN

Disrupted pancreatic ducts: t h e r a p y of pseudocysts, ascites and fistulae. Marc F. Catalano. Milwaukee, WI

Panel discussion and questions.

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Louis Y. Korman, Melvin Shapiro

MINIMAL STANDARDS Attendees will learn about the development and evaluation of standards for endoscopic reports and imaging. I n t r o d u c t i o n to w o r k s h o p . Melvin Schapiro. Los Angeles, CA

D o e s t h e level of t r a i n i n g o r t h e n u m b e r of e n d o s c o p i s t s p r e d i c t c o m p l i c a t i o n s a f t e r ERCP?

(Abstract# 125) H Montes, KY Ho, MJ Sossenheimer, J Vandervoort, R Soetikno, F Ruymann, J Van Dam and DL Carr-Locke. Boston, MA D u r a t i o n of colonoscopy: t h e effect of t r a i n e e p r e s e n c e o n procedure t i m e . (Abstract# 129)

N Nickl, J Vaughan, PB Cotton, P Jowell, E Libby and S Schutz. Lexington, KY; Charleston, SC; Durham, NC; Boston, MA and San Antonio, TX Do we p r a c t i c e w h a t we p r e a c h ? Clinical d e c i s i o n m a k i n g and u t i l i z a t i o n of e n d o s c o p i c u l t r a s o u n d for

I n t r o d u c t i o n to m i n i m a l s t a n d a r d t e r m i n o l o g y : background & principles. Massimo Crespi. Rome, Italy

gastrointestinal m a l i g n a n c i e s . (Abstract# 113)

M i n i m a l s t a n d a r d t e r m i n o l o g y for EGD.

CLINICAL E N D O S C O P I C P R A C T I C E : COST AND OPEN ACCESS

Michel Delvaux. Toulouse, France M i n i m a l s t a n d a r d t e r m i n o l o g y for colonoscopy.

Louis Y. Korman. Washington, DC M i n i m a l s t a n d a r d t e r m i n o l o g y for ERCP.

Oliver Cass. Minneapolis, MN M i n i m a l s t a n d a r d t e r m i n o l o g y for e n d o s c o p i c

ultrasound. Lars Aabakken and Chris Kim. Oslo, Norway and Charleston, SC ASGE Poster Session

8:00 am-5:00 p m

Hall D Ernest N. Morial Convention Center

Authors are required to present during the Poster Session from 12:00-2:30 pm

Those posters identified as D D W Posters of Distinction have received review scores that place them within the top 10% of all posters. We encourage you to make them a priority as you visit the poster session. C L I N I C A L E N D O S C O P I C PRACTICE: E D U C A T I O N AND T R A I N I N G F u r t h e r d e v e l o p m e n t s i n t h e "swine model" for teaching diagnostic and interventional endoscopic u l t r a s o u n d . (Abstract# 80) MS Bhutani, HF Stills, Jr and MA Aveyard. Dayton, OH Interactive, m u l t i m e d i a s o f t w a r e for p a t i e n t c o l o n o s c o p y e d u c a t i o n i n an o p e n access setting: a r a n d o m i z e d , c o n t r o l l e d t r i a l . (Abstract# 139)

MJ Shaw, PA Tomshine, TJ Beebe and OW Cass. Minneapolis, MN G a s t r o e n t e r o l o g y t r a i n e e m i s s - r a t e for colon polyps: a p r o s p e c t i v e s t u d y of t a n d e m colonoscopic e x a m i n a t i o n s . (Abstract# 91)

WZ Davis and PS J0well. Durham, NC D o '~nands-on" t r a i n i n g courses i n flexible

s i g m o i d o s c o p y i m p a c t t h e p r a c t i c e p a t t e r n s of p r i m a r y c a r e p h y s i c i a n s ? (Abstract# 130) PI Okolo, III, GT Gislason, M Bedine and AN Kalloo. Baltimore, MD The r o l e of a d v a n c e d t r a i n i n g f e l l o w s h i p s in t e a c h i n g n e e d l e - k n i f e p a p i l l o t o m y . (Abstract# 131) WG Parsons, J J Bosco and DA Howell. Chicago, IL; Burlington, MA and Portland, ME

LS Kim and J Koch. San Francisco, CA

DDW Poster of Distinction: Cost-effectiveness o f c o m b i n a t i o n e n d o s c o p i c l i g a t i o n and s c l e r o t h e r a p y versus e n d o s c o p i c s c l e r o t h e r a p y alone for severe e s o p h a g e a l v a r i c e a l h e m o r r h a g e . (Abstract# 103)

IM Gralnek, DM Jensen, TOG Kovacs, R Jutabha, G Machicado, ME Jensen, J King and the UCLA-CURE Hemostasis Research Group. Los Angeles, CA Does o p e n access e n d o s c o p y close t h e d o o r to an a d e q u a t e l y i n f o r m e d p a t i e n t ? (Abstract# 141)

D Staff, K Saeian, F Rochling, S Narayanan, M Kern, R Shaker and W Hogan. Milwaukee, WI P a t i e n t e v a l u a t i o n of o p e n access e n d o s c o p y a t an a c a d e m i c m e d i c a l center. (Abstract# 84) RJ Charles, A Chak, GS Cooper, RCK Wong, C Brown and MV Sivak, Jr. Cleveland, OH

DDW Poster of Distinction: A p p r o p r i a t e n e s s of o p e n access e n d o s c o p y a t a n a c a d e m i c m e d i c a l center. (Abstract# 83) RJ Charles, A Chak, GS Cooper, RCK Wong and MV Sivak, Jr. Cleveland, OH Does a n o p e n access p o l i c y w o r k for colon c a n c e r s c r e e n i n g u s i n g flexible s i g m o i d o s c o p y ? (Abstract# 119) JG Lee, S Saavedra, JW Leung, R Hsu and H Vigil. Sacramento, CA CLINICAL E N D O S C O P I C PRACTICE: O U T C O M E S RESEARCH D e t e r m i n i n g the i n d i c a t i o n s for d i a g n o s t i c u p p e r e n d o s c o p y u s i n g the ASGE guidelines: can nonp h y s i c i a n s do just as w e l l as p h y s i c i a n s ? (Abstract# 118)

JG Lee, S Saavedra, H Vigil, JW Leung and R Hsu. Sacramento, CA

DDW Poster of Distinction: Yield of u p p e r e n d o s c o p y i n dyspepsia; a m u l t i c e n t e r database study. (Abstract# 87)

PB Cotton, J Vaughan, P Mauldin, N Nickl, S Schutz, E Libby and P Jowell. Charleston, SC; Lexington, KY; San Antonio, TX; Boston, MA and Durham, NC P r o s p e c t i v e a n a l y s i s of n e g a t i v e o u t c o m e s 30 d a y s a f t e r o u t p a t i e n t u p p e r e n d o s c o p y . (Abstract# 149) R Zubarik, C Mastropietro, J Carroll, J Lopez, SB Benjamin, DE Fleischer and GM Eisen. Washington, DC and Memphis, TN

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A S G E P O S T E R S E S S I O N - - W E D N E S D A Y , MAY 20, 1998 P r o s p e c t i v e a n a l y s i s of n e g a t i v e o u t c o m e s 30 days after o u t p a t i e n t colonoscopy. (Abstract# 148) R Zubarik, C Mastropietro, J Carroll, J Lopez, SB Benjamin, DE Fleischer and GM Eisen. Washington, DC and Memphis, TN Outcome of e n d o s c o p y i n p a t i e n t s w i t h i r o n deficiency a n e m i a a n d a p r e v i o u s h i s t o r y of p a r t i a l gastrectomy. (Abstract# 81) EJ Bini, JS Unger and EH Weinshel. New York, NY F e a t u r e s w h i c h m a y p r e d i c t a d m i s s i o n following o u t p a t i e n t t h e r a p e u t i c ERCP. (Abstract# 108) KY Ho, H M0ntes, MJ Sossenheimer, T Tham, J Vandervoort, F Ruymann, J Van Dam and DL Carr-Locke. Boston, MA

Efficacy of various d i s i n f e c t a n t s i n k i l l i n g a resistant strain of P s e u d o m o n a s b y c o m p a r i n g z o n e s of inhibition: i m p l i c a t i o n s for r e p r o c e s s i n g of endoscopic e q u i p m e n t . (Abstract# 115) BJ Kovacs, RM Aprecio, JD Kettering and YK Chen. Loma Linda, CA A p e r f o r m a n c e , safety a n d cost c o m p a r i s o n of r e u s a b l e v e r s u s disposable endoscopic b i o p s y forceps: a p r o s p e c t i v e r a n d o m i z e d trial. (Abstract# 134) J Rizzo, DE Bernstein, J Tripodi and F Gress. Mineola, NY

In vitro e v a l u a t i o n of r e u s a b l e d o u b l e c h a n n e l sphincterotomes. (Abstract# 122) RM Lee, F Vida, RA Kozarek, SL Raltz, SE Sumida and D Irizzary. Seattle, WA

P r e d i c t o r s of successful clinical, radiological a n d laboratory o u t c o m e s i n patients w i t h primary s c l e r o s i n g c h o l a n g i t i s u n d e r g o i n g ERCP. (Abstract# 96) R Enns, M Aloubeidi, K Mergener, MS Branch, PS JoweU and J Bafllie. Durham, NC

E n d o s h e a t h : a disposable, sheathed, flexible gastroscopy: a p r o s p e c t i v e r a n d o m i z e d trial. (Abstract# 123) B Mayinger, J Hochberger, M Strenkert, P Martus and EG Hahn. Erlangen, Germany

DDW Poster of Distinction:

C o m p a r a t i v e e v a l u a t i o n of disposable versus r e u s a b l e b i o p s y forceps costs. (Abstract# 92) PH Deprez, M Van Hassel, P Hoang, H Piessevaux, R Fiasse, Y Horsmans, D Vandenbosch and A Geubel. Brussels, Belgium

T r a n s n a s a l gastroscopy: a r a n d o m i z e d s t u d y to analyze the feasibility a n d the p a t i e n t tolerance. (Abstract# 18) J Dumortier, T Ponchon, B Moulinier, P Paliard, F Zarka and R Lambert. Lyon, France CLINICAL E N D O S C O P I C PRACTICE: D I S I N F E C T I O N , R E P R O C E S S I N G AND DISPOSABLES R e p r o c e s s i n g of s i n g l e use ERCP c a n n u l a s by low t e m p e r a t u r e h y d r o g e n peroxide gas plasma sterilization. (Abstract# 136) A Schulte-Bockholt, T Dietze, C Biittner, D Zimmermann, U Rosenstock, G Friedrich, HK Geiss and M Keymling. Meiningen, Germany

DDW Poster of Distinction: The successful r e p r o c e s s i n g of disposable biopsy forceps. (Abstract# 132) DS Pratt, TA Knox, M Faison, K Hansjosten, L Rider and M Barza. Boston, MA Efficacy of c o n v e n t i o n a l endoscopic disinfection/ s t e r i l i z a t i o n m e t h o d s a g a i n s t Itelicobacterp~lori c o n t a m i n a t i o n . (Abstract# 88) JR Cronmiller, DK Nelson, DK Jackson and CH Kim. Rochester, NY E n d o s c o p e d i s i n f e c t i o n after u p p e r digestive t r a c t e n d o s c o p y i n h e p a t i t i s C virus-positive patients. (Abstract# 101) JL Gaudin, P ChevaUier, B Laurendon, A Tailhandier and JC Souquet. Lyon, France G a s t r o i n t e s t i n a l endoscope reprocessing: c u r r e n t and p r e v i o u s practices. (Abstract# 85) R Cheung, D Ortiz, M Allen and A DiMarino. Philadelphia, PA High-level d i s i n f e c t i o n of flexible g a s t r o i n t e s t i n a l endoscopes u s i n g a c o m b i n a t i o n of g l u t a r a l d e h y d e a n d p e r a c e t i c acid. (Abstract# 99) RL Foliente, RM Aprecio, BJ Kovacs, JD Kettering, I Roy and YK Chen. Loma Linda, CA E n d o s c o p e d i s i n f e c t i o n m a y n o t always be effective: the ~'Y" c o n n e c t i o n is a n u n n e c e s s a r y Achilles heel of the d i s i n f e c t i o n process. (Abstract# 112) J Kim, T Officer and DY Graham. Houston, TX

CLINICAL ENDOSCOPIC PRACTICE: SEDATION AND CONTROL OF P A T I E N T ANXIETY

DDW Poster of Distinction: A r a n d o m i z e d t r i a l of p e r o r a l v e r s u s t r a n s n a s a l u n s e d a t e d endoscopy u s i n g a n u l t r a t h i n video endoscope. (Abstract# 147) A Zaman, M Hahn, R Hapke, K Knigge, MB Fennerty and R Katon. Portland, OR F a c t o r s associated w i t h t o l e r a n c e to u n s e d a t e d u p p e r g a s t r o i n t e s t i n a l endoscopy. (Abstract# 128) HE Mulcahy, P Kelly, M Banks, MJG Farthing, PD Fairclough and P Kumar. London, United Kingdom The i m p a c t of m u s i c o n t h e a n x i e t y level of p a t i e n t s u n d e r g o i n g o u t p a t i e n t e n d o s c o p y - a prospective r a n d o m i z e d controlled study. (Abstract# 110) RK Hsu, M Veridiano, J Inciardi, P Soares, C Stefani and J Leung. Sacramento, CA A s s e s s m e n t of p a t i e n t discomfort d u r i n g diagnostic upper endoscopy under conscious sedation a prospective study. (Abstract# 109) RK Hsu, JF Inciardi, JG Lee and JW Leung. Sacramento, CA A c o m p a r i s o n of n a r r o w bore t r a n s n a s a l a n d t r a n s o r a l endoscopy i n u n s e d a t e d p a t i e n t s . (Abstract# 14) A Craig, M Schoeman and J Dent. Adelaide, Australia

DDW Poster of Distinction: E x p e r i e n c e with d r o p e r i d o l d u r i n g s p h i n c t e r of Oddi m a n o m e t r y . (Abstract# 98) E Fogel, S Sherman, L Bucksot and G Lehman. Indianapolis, IN

DDW Poster of Distinction: Complications a n d a d v e r s e effect of eolonoscopy w i t h selective sedation. (Abstract# 94) VF Eckardt, G Kanzler, T Schmitt and AJ Eckardt. Wiesbaden, Germany

P186 PROGRAMOF THE ANNUALMEETING

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The c o m p a r i s o n of m i d a z o l a m a n d t o p i c a l l i d o c a i n e s p r a y v e r s u s t h e c o m b i n a t i o n of m i d a z o l a m , m e p e r i d i n e a n d t o p i c a l l i d o c a i n e s p r a y to s e d a t e p a t i e n t s for u p p e r e n d o s c o p y . (Abstract# 117) L La Luna, M Allen and AJ DiMarino. Philadelphia, PA

A p p r o p r i a t e u s e of a n t i m i c r o b i a l p r o p h y l a x i s for patients undergoing gastrointestinal endoscopy. (Abstract# 107) KY Ho, B O'Neill, S Cialfi, H Montes, MJ Sossenheimer, F Ruymann, J Van Dam and DL Carr-Locke. Boston, MA

Efficacy a n d s a f e t y of t h r e e r e g i m e n s of conscious s e d a t i o n for g a s t r o s c o p y : a r a n d o m i z e d d o u b l e - b l i n d p r o s p e c t i v e s t u d y . (Abstract# 127) SM Muehldorfer, H Reh, EG Hahn and C Ell. Erlangen and Wiesbaden, Germany

A p r o s p e c t i v e , r a n d o m i z e d t r i a l to a s s e s s t h e usefulness of g l u c a g o n to a i d i n t r a i n i n g d u r i n g e n d o s c o p i c r e t r o g r a d e c h o l a n g i o p a n c r e a t o g r a p h y . (Abstract# 90) P Darwin, A Rosenstein and O Haluszka. Baltimore, MD

DDW Poster of Distinction: R a n d o m i z e d c o n t r o l l e d t r i a l o f p r o p o f o l for p a t i e n t sedation during endoscopic retrograde c h o l a n g i o p a n c r e a t o g r a p h y . (Abstract# 114) LS Kim, WB Cammarano, LA Querimit, CR Bainton and JP Cello. San Francisco, CA C L I N I C A L E N D O S C O P I C PRACTICE: SAFETY, COMPLICATIONS AND OTHER CLINICAL ENDOSCOPY A n t i b i o t i c p r o p h y l a x i s for t h e r a p e u t i c b i l i o p a n c r e a t i c non-surgical procedures: a randomized study c o m p a r i n g a m o x i c i l l i n - c l a v u l a n i c a c i d a n d piperacUlin. (Abstract# 142) F Thieulin, C Lak, T Ponchon, MC Graber and L Henry. Lyon, France I n c i d e n c e of c o m p l i c a t i o n s a f t e r e n d o s c o p i c gastrointestinal procedures in the elderly population: a r e t r o s p e c t i v e a n d p r o s p e c t i v e study. (Abstract# 75) MR Antillon, T Tran, R Wu, M Alamy, S Vashishtha, C Enrique and T Nguyen. Los Angeles, CA

DDW Poster of Distinction: I n t r a v e n o u s f l u i d s v e r s u s s a l i n e l o c k in elective gastrointestinal endoscopic procedures. A prospective r a n d o m i z e d s t u d y . (Abstract# 76) MR Antillon, T Tran, R Wu, C Enrique, M Alamy, S Vashishta, C-P Wong, C Thomas and M Oh. Los Angeles, CA Safety of day-case endoscopic cholangiopancreatograph3~ a prospective series. ( A b s t r a c t # 100) C Fox, S Cairns, R Harry and B James, Brighton, United Kingdom A c o m p a r i s o n of novel, low-dose, t r i p l e r e g i m e n w i t h F l e e t p h o s p h o s o d a : a s t u d y of colon cleanliness, s p e e d a n d success of colonoscopy. (Abstract# 86) AP Chflton, M O'Sullivan, DE Loft and CU Nwokolo. Coventry, United Kingdom The r i s k of b l e e d i n g f o l l o w i n g e n d o s c o p i c b i o p s y i n p a t i e n t s w i t h t h r o m b o c y t o p e n i a . (Abstract# 82) RE Brand, S Kathol, KS Harmon and EMM Quigley. Omaha, NE N a s a l c a n n u l a w i t h g r a p h i c d i s p l a y of r e s p i r a t o r y r a t e a n d p a t t e r n is t h e m o s t s e n s i t i v e d e t e c t o r of r e s p i r a t o r y d e p r e s s i o n d u r i n g t h e r a p e u t i c endoscopy. (Abstract# 144) J Varg0, G Zuccar0, J Ryckman and D ConweU. Cleveland, OH

DDW Poster of Distinction: N a s o p h a r y n g e a l v e r s u s t r a n s c u t a n e o u s CO 2 m o n i t o r i n g d u r i n g ERCP. (Abstract# 145) J Varg0, G Zuccar0, D C0nwcll, J Ryckman and S Shay. Cleveland, O H

Colonoscopy p r e p a r a t i o n : p r e t r e a t m e n t w i t h a s t i m u l a n t l a x a t i v e b e f o r e PEG-ELS does n o t affect s e r u m e l e c t r o l y t e s o r h e m o d y n a m i c s . (Abstract# 135) J Schaberg, VK Sharma, S Chockalingam, R Vasudeva and CW Howden. Columbia, SC R e m o v a l of biofilm f r o m e n d o s c o p e c h a n n e l s u t i l i z i n g h i g h v e l o c i t y t u r b u l e n t flow technology. (Abstract# 79) SB Benjamin and M Labib. Washington, DC and Princeton, NJ Miss r a t e of Mallory-Weiss t e a r a f t e r p o l y e t h y l e n e glycol e l e c t r o l y t e l a v a g e solution. (Abstract# 105) M Guelrud, E T0rres, MA Vezga, I Herrera and S Mendoza. Caracas, Venezuela B i - d i r e c t i o n a l e n d o s c o p y u s i n g a single c o l o n o s c o p e is safe, effective, a n d cost- a n d time-efficient. (Abstract# 137) VK Sharma, SK Chockalingam, J Schaberg, R Vasudeva and CW Howden. Columbia, SC P r o s p e c t i v e e v a l u a t i o n of E R C P a c c e s s o r i e s u t i l i z e d a t two i n s t i t u t i o n s . (Abstract# 124) AS McIntosh and FC Ramirez. Phoenix, AZ R i s k : b e n e f i t r a t i o of u n i n t e n t i o n a l d u c t a l o p a c i f i c a t i o n at ERCP. (Abstract# 102) AJ Grade and FC Ramirez. Phoenix, AZ G A S T R O E S O P H A G E A L R E F L U X A N D BARRETT'S ESOPHAGUS Gastroesophageal reflux disease in patients with and w i t h o u t e n d o s c o p i c a b n o r m a l i t i e s : age a n d g e n d e r differences. (Abstract# 166) M Davila, R Davila and G Triadafflopoulos. Pale Alto and Stanford, CA Does Helieobacterpyloriplay a role i n g a s t r o e s o p h a g e a l reflux d i s e a s e ? (Abstract# 209) IM Subei, M Salama, S Elderiny and MJ O'Brien. Jeddah, Saudi Arabia and Boston, MA

DDW Poster of Distinction: P r o s p e c t i v e m u l t i v a r i a t e a n a l y s i s of f a c t o r s p r e d i c t i v e of e n d o s c o p i c a n d h i s t o l o g i c r e g r e s s i o n of B a r r e t t ' s e s o p h a g u s d u r i n g l o n g - t e r m follow-up. (Abstract# 162) AS Badr and AP Weston. Kansas City, MO and Kansas City, KS P r o g r e s s i o n of B a r r e t t ' s e s o p h a g u s to m u l t i f o c a l high-grade dysplasia or adenocarcinoma: prospective m u l t i v a r i a t e analysis. (Abstract# 161) AS Badr and AP Weston. Kansas City, MO and Kansas City, KS A c c u r a c y of p a t h o l o g i c i n t e r p r e t a t i o n of B a r r e t t ' s metaplasia and dysplasia by community hospital g e n e r a l p a t h o l o g i s t s . (Abstract# 160) M Alikhan, OW Cummings, T Ulbright and D Rex. Indianapolis, IN Clinical a n d e n d o s c o p i c p r e d i c t o r s of B a r r e t t ' s e s o p h a g u s at t h e i n d e x e n d o s c o p y . (Abstract# 169) M Eloubeidi and D Provenzale. Durham, NC

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ASGE

POSTER

SESSION--WEDNESDAY,

L o n g - t e r m r e v e r s a l of p a t i e n t s w i t h B a r r e t t ' s esophagus with multipolar electrocoagulation and h i g h d o s e o m e p r a z o l e . (Abstract# 206) P Sharma, E Camargo, HS Garewal and RE Sampliner. Tucson, AZ The l e n g t h of c o l u m n a r - l i n e d e s o p h a g u s a n d t h e f r e q u e n c y of i n t e s t i n a l m e t a p l a s i a . (Abstract# 203) RF Saidi, WK Fackler, SL Kim, JG Hunter, JM W0, LP Davis and JP Waring. Atlanta, GA P r e v a l e n c e of B a r r e t t ' s e s o p h a g e a l m u c o s a i n developmentally delayed adults presenting with c o v e r t d y s p h a g i a . (Abstract# 172) P Gocnka, LW Schmidt, RW Mcgowan, DB Welch, TR B0rthwick, IW Br0wder and MF Young. Johnson City, TN M e t h y l e n e b l u e s t a i n i n g in t h e follow-up of B a r r e t t ' s e s o p h a g u s . (Abstract# 174) MA Hasan, H Dras-Howard, A Balayut, P Shah, A Khan and K Gottlieb. Indianapolis, IN R e g r e s s i o n of B a r r e t t ' s e s o p h a g u s b y a n t i r e f l u x s u r g e r y a n d b i p o l a r e l e c t r o c o a g u l a t i o n . (Abstract# 196) CG Montes, NA Brandalise, R Deliza and JGP Ferraz. Campinas, Brazil F a i l u r e of o p t i c a l b i o p s i e s to d i s t i n g u i s h adenoc a r c i n o m a a n d d y s p l a s t i c B a r r e t t ' s e p i t h e l i u m from non-dysplastic Barrett's epithelium and squamous m u c o s a . (Abstract# 218) G Zuccaro, BD Kuban, J Arendt, TW Rice, JR Goldblum and RM Cothren. Cleveland, OH M a x i m u m c a p a c i t y ("jumbo") b i o p s y forceps v e r s u s l a r g e c a p a c i t y b i o p s y f o r c e p s for e n d o s c o p i c s u r v e i l l a n c e of p a t i e n t s w i t h B a r r e t t ' s esophagus. (Abstract# 164) YK Chen, KS Thompson, RL Foliente, BJ Kovacs and R Griffin. Loma Linda, CA ESOPHAGEAL CANCER E n d o s c o p i c a s s e s s m e n t of t u m o r v i a b i l i t y a f t e r c o m b i n e d c h e m o r a d i a t i o n for e s o p h a g e a l cancer. (Abstract# 216) A W0ng, M Suntharalingam, A Doyle, J S0nett, M Krasna and BD Greenwald. Baltimore, MD U l t r a - h i g h m a g n i f i c a t i o n e n d o s c o p y for e a r l y - s t a g e e s o p h a g e a l c a n c e r . (Abstract# 181) H Inoue, K Nagai, T Kawano and K Takeshita. Tokyo, Japan E U S / F N A : c o m p a r a t i v e e x p e r i e n c e in d e t e c t i o n a n d d i a g n o s i s of celiac LN in e s o p h a g e a l c a n c e r . (Abstract# 195) G Mishra, AV Sahai, ID Penman, DB Williams, WL Knapple, H Hunt, RH Hawes, CE Reed and BJ Hoffman. Charleston, SC CT versus

Efficacy a n d s a f e t y of e s o p h a g e a l m e t a l s t e n t s in m a l i g n a n t d y s p h a g i a . (Abstract# 202) AB Rosenberg, B Cvetkovski, RC Kurtz, M Bains and H Gerdes. New York, NY Ten y e a r c o m p a r i s o n of e x p a n d a b l e e s o p h a g e a l s t e n t s for m a l i g n a n t e s o p h a g e a l s t r i c t u r e s . (Abstract# 185) RA K0zarek, TJ Ball, JJ Brandabur, DJ Patterson and SL Raltz. Seattle, WA P r e d i c t i o n of s u r v i v a l in p a t i e n t s u n d e r g o i n g esophageal expandable metal stent placement. (Abstract# 177) SJ Heller, G Haber, C Ross, S Jonnalagadda, A Stefan, H Ter, G Kandel, P Kortan and N Maroon. Toronto, Canada

MAY20,

1998

Usefulness of c o m b i n e d t h e r a p y w i t h e n d o s c o p i c m u c o s a l r e s e c t i o n a n d r a d i a t i o n for s u p e r f i c i a l e s o p h a g e a l c a n c e r . (Abstract# 211) T Tanimoto, S Tanaka, K Haruma, T Shimizu, K Kitadai, M Yoshihara, K Sumii, G Kajiyama, Y Akagi, Y Hirokawa and F Shimamoto. Hiroshima, Japan P h o t o d y n a m i c t h e r a p y for h i g h - g r a d e d y s p l a s i a a n d e a r l y a d e n o c a r c i n o m a of t h e e s o p h a g o g a s t r i c j u n c t i o n a n d g a s t r i c c a r d i a in e l d e r l y p a t i e n t s w i t h s h o r t s e g m e n t B a r r e t t ' s e s o p h a g u s . (Abstract# 205) D Schembre, C Lightdale, R Ligresti, P Stevens and H Rotterdam. New York, NY A r g o n p l a s m a c o a g u l a t i o n in t h e t r e a t m e n t of esophageal high-grade dysplasia or early carcinoma: c u r e o r p a l l i a t i o n ? (Abstract# 213) J-L Van Laethem, R Jagodinski, J Deviate and M Cremer. Brussels, Belgium VARICES, A C H A L A S I A A N D O T H E R C L I N I C A L ESOPHAGOSCOPY M e d i c a l v e r s u s e n d o s c o p i c t h e r a p y for p r e v e n t i o n of v e r i c e a l r e b l e e d i n g : t h e effect of p a t i e n t c o m p l i a n c e . (Abstract# 179) JM Inadomi, GM Eisen and A Sonnenberg. Albuquerque, NM and Memphis, TN O b l i t e r a t i o n of e s o p h a g e a l v a r i c e s u s i n g E U S - g u i d e d s c l e r o t h e r a p y w i t h color D o p p l e r : c o m p a r i s o n w i t h e s o p h a g e a l b a n d ligation. (Abstract# 163) MF Catalano, S Lahoti, E Alcocer, WJ Hogan, JB Nelson and JE Geenen. Milwaukee, WI and Houston, TX

DDW Poster of Distinction: E n d o s c o p i c i n j e c t i o n of b l e e d i n g e s o p h a g e a l v a r i c e s u s i n g poly-N-acetyl g l u c o s a m i n e gel i n d u c e s h e m o s t a s i s a n d v a r i x o b l i t e r a t i o n i n one session. (Abstract# 188) D Kulling, RH Hawes, S Woo, MV Demcheva, DU Tagge, G Rios, S Finkielsztein and JN Vournakis. Charleston, SC and Danvers, MA S p o n t a n e o u s b a c t e r i a l p e r i t o n i t i s a n d a s c i t i c polymorphonuclear elastase after injection sclerotherapy a n d b a n d l i g a t i o n for e s o p h a g e a l varices. (Abstract# 198) I Mostafa, M Omar, S Fakhry, B Monieer, M Omar and M Allam. Cairo, Egypt Cytoprotective and cytoinjurious factors in chronic l i v e r d i s e a s e s w i t h b l e e d i n g g a s t r o e s o p h a g e a l varices. (Abstract# 197) I Mostafa, M Hassan, F Essawy and S Omran. Cairo, Egypt M u l t i l i g a t i o n of e s o p h a g o g a s t r i c v a r i c e s - a p r o s p e c t i v e s t u d y of 87 p a t i e n t s a n d 271 t r e a t m e n t sessions. (Abstract# 178) J Hochberger, H Reh, F HSrning, D SchSpplein, P Martus and EG Hahn. Erlangen, Germany E n d o s c o p i c t r e a t m e n t for e s o p h a g e a l v a r i c e s w i t h m i c r o w a v e s . (Abstract# 187) T Kuga, K Higuchi, T Arakawa, M Shiba, T Uchida, N Hamasaki, K Ando, Y Fujiwara, K Kobayashi and T Kuroki. Osaka, Japan A b s o l u t e e t h a n o l is as effective as 5% e t h a n o l a m i n e oleate for s c l e r o t h e r a p y of e s o p h a g e a l varices. (Abstract# 204) JOM Santos, AF Carvalho, Jr, FC Neto, LA Magna, JMR Zeitune, NA Brandalise and JGP Ferraz. Campinas, Brazil

P188PROGRAMOFTHEANNUALMEETING II

ASGE

POSTER

GASTROENTEROLOGY

SESSION

-- WEDNESDAY,

Vol.114~No.4

MAY 20, 1998

DDW Poster of Distinction:

DDW Poster of Distinction:

L o n g - t e r m o u t c o m e of p n e u m a t i c d i l a t a t i o n i n p a t i e n t s w i t h a c h a l a s i a . (Abstract# 208) AM Stefan, PP Kortan, GB Haber, M Cirocc0, S Heller, S Jonnalagadda, H Ter, GP Kandel and NE Marc0n. Toronto, Canada

Nonsteroidal antiinfiammatory drugs are strong p r e d i c t o r s for r e b l e e d i n g in p a t i e n t s w i t h u p p e r GI b l e e d i n g a n d p e p t i c u l c e r disease. (Abstract# 256) DT Nason, MP Pauly, P Spinka, J F Inciardi and W Trudeau. Sacramento, CA

I m p r o v e m e n t i n d y s p h a g i a is s u s t a i n e d a f t e r esophageal expandable metal stent placement. (Abstract# 176) SJ Heller, G Haber, S Jonnalagadda, A Stefan, H Ter, C Ross, G Kandel, P K0rtan and N Marc0n. Toronto, Canada

R e c e n t NSAID u s e i n c r e a s e s r i s k of e a r l y r e b l e e d i n g in p a t i e n t s p r e s e n t i n g w i t h b l e e d i n g ulcer. (Abstract# 239) A G0dil, L DeGuzman, RC Schilling, SA Khan and YK Chen. L0ma Linda, CA

U t i l i z a t i o n of i n t r a l e s i o n a l s t e r o i d i n j e c t i o n s in difficult e s o p h a g e a l s t r i c t u r e s . (Abstract# 217) FD Wright, LP Davis, JG Hunter and JP Waring. Atlanta, GA

Long-term follow-up of D i e u l a f o y lesion. (Abstract# 259) ID Norton, BT Petersen, RK Balm, A GeUer, CJ G0stout and the GI Bleeding Team. Rochester, MN Cause of b l e e d i n g n o t f o u n d - d o e s i t m a t t e r ? (Abstract# 237) A Fraser, J Mass0n and NAG Mowat. Aberdeen, Scotland

N o n - m a l i g n a n t o b s t r u c t i o n is a c o m m o n p r o b l e m w i t h m e t a l s t e n t s i n t h e t r e a t m e n t of e s o p h a g e a l c a n c e r . (Abstract# 192) W Mayoral, JA Salcedo, PK Roy, F A1-Kawas, SB Benjamin and DE Fleischer. Washington, DC

T o t a l p e r o r a l i n t r a o p e r a t i v e e n t e r o s c o p y for o b s c u r e GI b l e e d i n g u s i n g a d e d i c a t e d p u s h e n t e r o s c o p e : d i a g n o s t i c y i e l d a n d p a t i e n t outcome. (Abstract# 280) A Zaman, B Sheppard and RM Katon. Portland, OR

P r o s p e c t i v e c o m p a r i s o n of e s o p h a g e a l b r u s h i n g to e s o p h a g e a l b i o p s y i n t h e d i a g n o s i s of C a n d i d a e s o p h a g i t i s . (Abstract# 191) AP Manocha, K Darwish, J Aranda-Michel and BL Bleau. Cincinnati, OH

The u t i l i t y of side-viewing d u o d e n o s c o p e as a c o m p l e m e n t a r y m e a s u r e to p u s h e n t e r o s c o p y in t h e d i a g n o s i s a n d m a n a g e m e n t of o b s c u r e GI b l e e d i n g . (Abstract# 277) H Wazaz, U Sjoqvist and B Lewis. New York, NY

P r e l i m i n a r y c l i n i c a l e x p e r i e n c e w i t h t h e n e w CItE T M m u l t i d i a m e t e r b a l l o o n for d i l a t a t i o n of e s o p h a g e a l s t r i c t u r e s . (Abstract# 186) AR Kruse, JA Goldstein and JS Barkin. Miami, FL

Outcome of p a t i e n t s w i t h a c t i v e g a s t r i c v a r i c e a l bleeding and those with stigmata of recent h e m o r r h a g e . (Abstract# 245) M Hosseini. Davis, CA

E n d o s c o p i c - l a p a r o s c o p i c e s o p h a g e a l m y o t o m y for a c h a l a s i a : d e s c r i p t i o n of a n e w t e c h n i q u e . (Abstract# 537) P Brady, A Rosemurgy, Z Baig and B Nease. Tampa, FL

Long-term r e c u r r e n t b l e e d i n g r a t e of b l e e d i n g p e p t i c ulcer. (Abstract# 263) E-R Park, H-Y Jung, S-K Yang, KN Shim, H-R Kim, W-S Hong and YI Min. Se0ul, Korea

The u s e f u l n e s s of e n d o s c o p i c m a n o m e t r i c sleeve assembly. (Abstract# 173) M Hananoki, K Haruma, J Hata, E Okamoto, H Kusun0ki, N Yamashita, S Yoshida, S A0ki, S Tanaka, M Yoshihara, K Sumii and G Kajiyama. Hir0shima, Japan

Outpatient versus hospital care after endoscopic injection in selected patients bleeding from peptic ulcer. P r e l i m i n a r y r e s u l t s of a r a n d o m i z e d s t u d y . (Abstract# 227) E BruUet, R Campo, X Calvet, L Catot, J Cabrol and E Lap0rto. Sabadell, Spain

Clinical p r e d i c t o r s of l a r g e v a r i c e s i n c i r r h o t i c p a t i e n t s . (Abstract# 78) HX Barcia, GA Robalino, EG Molina, KR Reddy, L Jeffers, M Rodriguez and ER Schiff. Miami, FL The p r e - t i e d l o o p e s o p h a g e a l v a r i c e s l i g a t i o n is better than the rubber band ligation technique. (Abstract# 24) K Hashiba, D Moribe, S Armelini, HA Brasil, MA D'Assun~o, R Salina and JLS Carvalho. Sao Paulo, Brazil G a s t r o i n t e s t i n a l e n d o s c o p y as a s c r e e n i n g m e t h o d for c y t o m e g a l o v i r u s i n f e c t i o n following a l l o g e n e i c b o n e m a r r o w t r a n s p l a n t a t i o n . (Abstract# 279) T Yajima, Y Iwao, T Hisamatsu, S Okamato, Y Ikeda, H Sugiura, M Mukai, T Kanai, H Ogata, M Watanabe, T Hibi and H Ishii. Tokyo, Japan GI B L E E D I N G

DDW Poster of Distinction: P r e d i c t i v e v a l u e of a p o s i t i v e fecal occult b l o o d t e s t for u p p e r g a s t r o i n t e s t i n a l lesions i n a s y m p t o m a t i c p a t i e n t s w i t h a n e g a t i v e colonoscopy. (Abstract# 224) EJ Bini, MT Valdes and EH Weinshel. New York, NY

Clinical i m p a c t o f e n d o s c o p i c h e m o s t a s i s f o r nonvariceal bleeding: an evidence-based meta-analysis. (Abstract# 231) L Cipolletta, R Marmo, MA Bianco, G Rotondano and R Piscopo. Torre del Greco, Italy

DDW Poster of Distinction: Surgical r e s c u e for f a i l e d e n d o s c o p i c h e m o s t a s i s i n b l e e d i n g p e p t i c ulcers: a five y e a r audit. (Abstract# 251) JYW Lau, WK Wang, ACW Chan, ALM Yu, EKW Ng, JJY Sung and SCS Chung. Shatin, Hang Kong

DDW Poster of Distinction: I n i t i a l r e s u l t s of a p r o s p e c t i v e s t u d y of c o m b i n a t i o n b a n d i n g a n d s c l e r o t h e r a p y c o m p a r e d to s c l e r o t h e r a p y alone for b l e e d i n g g a s t r i c varices. (Abstract# 249) R Jutabha, DM Jensen, TOG Kovacs, GA Machicado, IM Gralnek, J King and ME Jensen. Los Angeles, CA Endoscopic injection sclerotherapy compared with e n d o s c o p i c c o m b i n e d (injection a n d l i g a t i o n ) t h e r a p y for g a s t r i c v a r i c e a l bleeding. (Abstract# 230) JY Cho, SJ Hong, JH Moon, YD Cho, JH Kim, JS Lee, YS Kim, MS Lee, SG Hwang and CS Shim. Seoul, Korea

April1998

PROGRAMOF THEANNUALMEETINGP189

ASGE POSTER SESSION - - W E D N E S D A Y , MAY 20, 1998 I n t e r i m r e s u l t s of a r a n d o m i z e d t r i a l c o m p a r i n g i n j e c t i o n t h e r a p y w i t h e p i n e p h r i n e - p o l i d o c a n o l 1% versus hemoclip versus injection combined with h e m o c l i p for b l e e d i n g ulcers. (Abstract# 234) E de Goede, AM Gevers, M Simoens, M Hiele and P Rutgeerts. Leuven, Belgium Efficacy of a 7Fr i n j e c t i o n gold p r o b e versus 10Fr h e a t e r p r o b e i n t r e a t i n g p a t i e n t s w i t h b l e e d i n g peptic ulcer: p r e l i m i n a r y r e s u l t s of a r a n d o m i z e d trial. (Abstract# 240) S Goodman, PD Stevens, J Fineg01d, RJ Garcia-Carrasqui]lo, PHR Green, F Meyer, R Rosenberg, SK Lewis, M Rubin, L Schneider, L Osbourne and CJ Lightdale. New York, NY T r e a t m e n t of g a s t r o d u o d e n a l ulcer p e r f o r a t i o n by l a p a r o s c o p y a n d gastroscopy u s i n g a n o m e n t a l plug. (Abstract# 538) N Halkic, J-M Calmes, M Gillet and P Pescatore. Lausanne, Switzerland E v a l u a t i o n of b l e e d i n g c o m p l i c a t i o n s i n cirrhotic p a t i e n t s u n d e r g o i n g d i a g n o s t i c laparoscopy u s i n g a 2mm laparoscope. (Abstract# 536) S Badalamenti, LJ Jeffer8, E Molina, MJ Rodriguez, P Rassam, P Mendez, R Khan and ER Schiff. Miami, FL E n d o s c o p i c b a n d l i g a t i o n for n o n - u l c e r n o n - v a r i c e a l g a s t r o i n t e s t i n a l h e m o r r h a g e . (Abstract# 219) D Abi-Hanna, I Valiozis, P GillesPie, SJ Williams and M Bourke. Sydney, Australia C o m p a r i s o n of endoscopic i n j e c t i o n m e t h o d s a n d h e m o c l i p p i n g as first-line t r e a t m e n t for peptic ulcer bleeding. (Abstract# 252) KJ Lee, ST Chung, JH Kim, KB Hahm and SW Cho. Suwon, Korea

D D W Poster of Distinction: A c o m p a r i s o n of c l i p p i n g m e t h o d s for endoscopic hemostasis. (Abstract# 274) CP Swain, F Gong, TN Mills and C Hepworth. London, United Kingdom The l o n g - t e r m o u t c o m e of p a t i e n t s with w a t e r m e l o n s t o m a c h t r e a t e d w i t h a r g o n p l a s m a coagulation. (Abstract# 65) H Ter, G Haber, G Kandel, P Kortan, SHeller, S Jonnalagada, A Stefan, C Ross, M Cirocco and N Marcon. Toronto, Canada

H E L I C O B A C T E R P Y L O R I AND OTHER G A S T R O D U O D E N A L U L C E R DISEASES C a n n o n - i n v a s i v e tests s u b s t i t u t e for histology i n the diagnosis of Helicobacterpyloriinfection? (Abstract# 243) M Hahn, DO Faigel, N Magaret, DA Lieberman and MB Fennerty. Portland, OR I n c i d e n c e a n d outcomes i n p a t i e n t s w i t h i d i o p a t h i c ulcers. (Abstract# 241) S Goodman, G Mfllspaugh, PD Stevens, J Finegold, PHR Green and CJ Lightdale. New York, NY The effect of w a r m i n g o n the s e n s i t i v i t y of I-I,P. fast r a p i d u r e a s e test: a p r o s p e c t i v e evaluation. (Abstract# 254) AP Manocha, K Darwish, J Aranda-Michel, GA Bracher, RE Weesner, BL Bleau and SP Martin. Cincinnati, OH C a n serologic d e t e c t i o n of CagA positive Helieobaeter pylori s t r a i n s p r e d i c t the p r e s e n c e of peptic u l c e r i n y o u n g d y s p e p t i c p a t i e n t s ? (Abstract# 268) T Rokkas, C Liatsos, E Petrid0u, G Papathe0dorou, E Kalafatis and A Karameris. Athens, Greece

Effect of p r e i m m e r s i o n of b i o p s y forceps i n f o r m a l i n o n Helicobacterpylor/urease a c t i v i t y detection. (Abstract# 278) AR Wettstein, CTH Loy, AS Field and DJ Frommer. Darlinghurst, Australia Differences i n diagnostic yield of u p p e r gastroi n t e s t i n a l endoscopy i n d y s p e p t i c p a t i e n t s o n p r o t o n p u m p i n h i b i t o r s a n d H2 r e c e p t o r a n t a g o n i s t s . (Abstract# 255) RMS Mitchell, JSA Collins, RGP Watson and TCK Tham. Belfast, Northern Ireland Factors i n f l u e n c i n g the d e p t h of gastric u l c e r a t i o n . (Abstract# 244) T Hasebe, S Harasawa and T Miwa. Kanagawa, Japan Are t h r e e gastric biopsy sets m o r e s e n s i t i v e t h a n only one set i n d e t e c t i n g H. p y l o r / i n peptic u l c e r p a t i e n t s ? (Abstract# 269) M Salama, IM Subei, S Elderiny and MJ O'Brien. Jeddah, Saudi Arabia and Boston, MA GASTRIC CANCER AND O T H E R DISEASES OF STOMACH AND D U O D E N U M P a l l i a t i o n of m a l i g n a n t gastric outlet a n d d u o d e n a l o b s t r u c t i o n u s i n g e x p a n d a b l e metallic stents. (Abstract# 265) I Raijman, I Siddique, J Ajani, D Evans, J Abbruzzese, S Lahoti and P Lynch. Houston, TX N e w s t r a t e g y of endoscopic m u c o s a l r e s e c t i o n

c o m b i n e d w i t h c h e m o t h e r a p y for g a s t r i c cancer. (Abstract# 220) M Akiyama, M Kasai, T Suto, M Ota and H Nakajima. Noshiro and Kuroishi, Japan Nitric oxide s y n t h a s e a n d p53 e x p r e s s i o n i n h u m a n gastric cancer. (Abstract# 266) A Rajnakova, P Goh and S Moochhala. Singapore, Singapore P a t t e r n of GI m e t a s t a s i s from e x t r a - g a s t r o i n t e s t i n a l sites. (Abstract# 221) V Amin, N Russell, J Linder, I Siddique and I Raijman. Houston, TX G a s t r o i n t e s t i n a l a r t e r i o v e n o u s m a l f o r m a t i o n s : clinical a n d endoscopic experience w i t h 124 p a t i e n t s a n d analysis of r i s k factors. (Abstract# 267) R Rego, GK Luthra, I Nassif, I Waxman and PJ Pasricha. Galveston, TX Technique, r e s u l t s a n d l o n g - t e r m o u t c o m e of endoscopic b a l l o o n d i l a t a t i o n for pyloric stenosis. (Abstract# 275) CP Swain. London, United Kingdom E x t e n s i o n of s q u a m o u s e p i t h e l i u m i n t o the p r o x i m a l s t o m a c h - a novel m u c o s a l a b n o r m a l i t y recognized b y a n e w endoscopic t e c h n i q u e . (Abstract# 236) R Fass and RE Sampliner. Tucson, AZ Endoscopic m a n a g e m e n t of p r o x i m a l small bowel a d e n o m a s i n familial a d e n o m a t o u s polyposis. (Abstract# 257) ID Norton, D S0rbi, A Geller, BT Petersen and CJ Gostout. Rochester, MN Endoscopic m a n a g e m e n t of s p o r a d i c p e r i a m p u l l a r y adenomas. (Abstract# 258) ID Norton, D S0rbi, A Geller, BT Petersen and CJ G0stout. Rochester, MN All t h a t scallops is n o t celiac disease. (Abstract# 272) VII Shah, H Rotterdam, D Kotler, S Goodman, R Rosenberg, A Fasano, PD Stevens, RJ Garcia-Carrasquillo and PHR Green. New York, NY and Baltimore, MD

P190 PROGRAMOF THE ANNUALMEETING II

ASGE

.

POSTER

GASTROENTEROLOGYVol.I14~No. 4 SESSION

-- WEDNESDAY,

MAY

20, 1998

Distal duodenal/jejunal advanced adenomas detected a t e n t e r o s c o p y in f a m i l i a l a d e n o m a t o u s polyposis: a p r o s p e c t i v e s t u d y . (Abstract# 253) J Lepr~tre, JC Saurin, T Ponchon, A Chavaillon, F Descos and JA Chayvialle. Lyon, France

L o c a t i o n of m e t a c h r o n o u s c o l o r e c t a l a d e n o m a s : is a total colonoscopy always necessary at surveillance? (Abstract# 310) G Nusko, U Mansmann, U Partzsch, T Kirchner and EG Hahn. Erlangen and Berlin, Germany

G a s t r o i n t e s t i n a l b l e e d i n g f r o m t h e "fragile ileum", a variant of the ischemic bowel syndrome diagnosed b y i n t r a o p e r a t i v e e n t e r o s c o p y . (Abstract# 223) K Battacharya, J Cortes, J Cooley, M L0pez, J Petr0s and DR Cave. Brighton, MA

Miss r a t e for p o l y p s d u r i n g s c r e e n i n g flexible sigmoidoscopy and characteristics of missed polyps. (Abstract# 302) S Lipsc0mb, J Dominguez and P Schoenfeld. Bethesda, MD

E n d o s c o p i c e v a l u a t i o n of p e r s i s t e n t a b d o m i n a l p a i n in patients undergoing alcohol and drug withdrawal. (Abstract# 242) ZV Gutnik, DR Mallipeddi, MA CeruUi and L-c Liang. Brooklyn, NY P E G A N D O T H E R U P P E R GI E N D O S C O P Y P E G f e e d i n g t u b e s : p o l y u r e t h a n e ( F r e k a ®) v e r s u s silicone (Bard®). A r a n d o m i z e d t r i a l . (Abstract# 276) SJ van den Hazel, G den Hart0g, JE Thies and CJJ Mulder. Arnhem, The Netherlands A 3 y e a r r e v i e w of P E G s i t e infections: t h e e m e r g e n c e of m e t h i c i l l i n - r e s i s t a n t S. aureus as a m a j o r p a t h o g e n . (Abstract# 229) KA Chaudhary, WK Clarkston, PG Cuddy, E Kuganeswaran and OJ Smith. Kansas City, MO Home discharge following outpatient percutaneous e n d o s c o p i c g a s t r o s t o m y is safe. (Abstract# 271) DL Seidner, RM Walsh, A Vogten, E Fedorov and MK Reinhardt. Cleveland, OH "The b u r i e d b u m p e r s y n d r o m e " - a n o n - i n v a s i v e m e t h o d to r e l e a s e m i g r a t e d i n t e r n a l P E G r e t e n t i o n b o l s t e r s . (Abstract# 270) A Schulte-Bockholt, U Rosenstock and M Keymling. Meiningen, Germany D e v e l o p m e n t o f a n o u t p a t i e n t a l g o r i t h m for PEG p l a c e m e n t in p a t i e n t s w i t h a m y o t r o p h i c l a t e r a l sclerosis, (Abstract# 222) MA Arman, HL Schoeppner, T Ben-Menachem and DS Newman. Detroit, MI and Tacoma, WA COLON: A D E N O M A , POLYP, C A N C E R O u t c o m e of c o l o r e c t a l c a n c e r s c r e e n i n g b y d i g i t a l rectal examination in asymptomatic

average-risk

i n d i v i d u a l s . (Abstract# 283) EJ Bini, MT Valdes and EH Weinshel. New York, NY C o m p a r a t i v e specificities o f a g u a i a c a n d a n i m m u n o c h e m i c a l fecal o c c u l t b l o o d t e s t a n d e l i m i n a t i o n of d i e t a r y r e s t r i c t i o n s . (Abstract# 317) P Rozen, Z Samuel and J Knaani. Tel Aviv, Israel Are f i r e f i g h t e r s a t a n i n c r e a s e d r i s k of d e v e l o p i n g c o l o r e c t a l n e o p l a s i a - a p r o s p e c t i v e s t u d y . (Abstract# 294) A Grade, R Gerkin, P Stufflebeam and R Manch. Phoenix, AZ

DDW Poster of Distinction: The c l i n i c o p a t h o l o g i c a l s t u d y of s e r r a t e d adenoma. (Abstract# 297) M Iwabuchi, N Hiwatashi, T Masuda, T Shhnada, K Yamashita, Y Kumagai, T M0rim0t0, Y Kin0uchi, M Noguchi, H Watanabe, S Takahashi, F Nagashima, M Chida, Y Katsurashima, T Oriuchi, S Takagi, K Negoro and T Toyota. Sendal, Japan

R i s k m a n a g e m e n t of p o s t - p o l y p e c t o m y l o w e r g a s t r o i n t e s t i n a l b l e e d i n g . (Abstract# 323) D Sorbi, I Norton, R Balm, AR Zinsmeister and CJ Gostout. Rochester, MN E n d o s c o p i c d e t e r m i n a t i o n of t h e a b e r r a n t c r y p t loci density by magnification chromoscopy: colorectal c a n c e r v e r s u s b e n i g n d i s e a s e s of t h e colon. (Abstract# 322) D Sorbi, LJ Burgart, DA Ahlquist, WE Kames, L Wang, AR Zinsmeister and CJ Gostout. Rochester, MN

DDW Poster of Distinction: P a t t e r n s of e n d o s c o p i c follow-up a f t e r s u r g e r y for n o n m e t a s t a t i c c o l o r e c t a l cancer. (Abstract# 286) GS Cooper, Z Yuan, A Chak and AA Rimm. Cleveland, OH

DDW Poster of Distinction: P o s s i b i l i t y of c u r a t i v e e n d o s c o p i c r e s e c t i o n for colorectal cancer with submucosally massive invasion. (Abstract# 325) S Tanaka, K Haruma, T Kimura, T Shimizu, T Oh-e, N Koike, K Kitadai, M Yoshihara, K Sumii, G Kajiyama and F Shimamoto. Hiroshima, Japan

DDW Poster of Distinction: P r o s p e c t i v e d e t e r m i n a t i o n of d i s t a l colon f i n d i n g s i n p a t i e n t s w i t h p r o x i m a l colon c a n c e r . (Abstract# 316) D Rex, A Chak, L Sack, D Bj0rkman, E Cravens, R Vasudeva, M Wiersema, D Barrido, T Gross, L Zeabart, D Lieberman, T Lemmel, S Buckley and V Portish. Indianapolis, IN Is a m a g n i f y i n g c o l o n o s c o p y m o r e u s e f u l t h a n o r d i n a r y colonoscopy for p r e d i c t i o n of p a t h o l o g i c a l d i a g n o s i s of c o l o r e c t a l t u m o r s ? (Abstract# 328) T Terai, H Nihei, Y Ohno, O Kobayashi, T Ogihara, A Namihisa, H Watanabe, H Miwa and N Sato. Tokyo, Japan M a g n i f y i n g colonoscopy d i s c r i m i n a t e s d e g r e e of a t y p i a i n small c o l o r e c t a l n e o p l a s i a . (Abstract# 327) CR Teixeira, NV Coelho, C Saul, RJ Torresini and EB Tonelotto. Porto Alegre, Brazil Are m a l i g n a n t p o t e n t i a l of c o l o r e c t a l t u m o r s d i f f e r e n t a c c o r d i n g to m a c r o s c o p i c a p p e a r a n c e ? A n a l y s i s of 65 s u b m u c o s a l c o l o r e c t a l cancer. (Abstract# 311) Y Ohno, T Terai, H Nihei, T Ogihara, H Miwa and N Sato. Tokyo, Japan G r o w t h p a t t e r n s of e a r l y c o l o r e c t a l c a r c i n o m a s . (Abstract# 300) S Kndo, H Yaman0, Y Imai and H Kusaka. Akita, Japan C h a r a c t e r i s t i c s of d e p r e s s e d e a r l y c o l o r e c t a l c a r c i n o m a . (Abstract# 299) S Kud0, H Yaman0, Y Imai and H Kusaka. Akita, Japan Small d e p r e s s e d lesions of t h e c o l o r e c t u m . (Abstract# 298) H Kashida, N Kimot0, T Watanabe, T Fukunaga, M Hirasa, K Ibuki, S T0mita, A Orino and A Todo. K0be, Japan

PROGRAMOFTHEANNUALMEETINGP191

April 1998

A S G E P O S T E R S E S S I O N - - W E D N E S D A Y , MAY 20, 1998 A s t u d y of widely fiat elevated lesions i n colorectal n e o p l a s m . (Abstract# 331) H Yamano, S Kudo, Y Imai, N Kusaka and M Osato. Akita, Japan

Colonoscopic b a l l o o n d i l a t i o n t h e r a p y for b o w e l s t r i c t u r e i n Crohn's disease - o p t i m a l b a l l o o n i n g p r e s s u r e a n d d u r a t i o n . (Abstract# 319) Y Sasaki, Y Uno, R Hada and A Munakata. Hirosaki, Japan

M a g n i f y i n g e n d o s c o p y is useful for e a r l y d e t e c t i o n of t h e r e c u r r e n t lesions after endoscopic piecemeal m u c o s a l r e s e c t i o n for large colon polyps. (Abstract# 307) T Matsumot0, N Suzuki, S Shiba, N Hamasaki, I Suwa, Y Sawa, W Ueda, K Watanabe, Y Watanabe, S Nakamura, N Oshitani, T Arakawa, K Kobayashi and K Kuroki. Osaka, Japan

A p p e n d i c e a l orifice i n f l a m m a t i o n as a skip lesion i n u l c e r a t i v e colitis: r e l a t i o n to m e d i c a l t h e r a p y a n d disease extent. (Abstract# 332) S-K Yang, H-Y Jung, BD Cho, SW Nam, KN Shim, E-R Park, W-S Hong and YI Min. Seoul, Korea

A s t u d y of i n v a s i v e c a n c e r of elevated lesions i n colorectal n e o p l a s m . (Abstract# 296)

Y Imai, T Komatsu, S Kudo, N Kusaka, H Yamano and M Osato. Akita, Japan F r e q u e n c y a n d endoscopic features of depressed type of colorectal s u b m u c o s a l i n v a d i n g cancers. (Abstract# 324)

S Tamura, J Miyazaki, T Yah0, J Ohsaki, S Kagiyama, H Ueta, M M0rita, K Nakaj0, K Miyam0t0, Y Y0k0yama, A Kaneko, K Yamashita, Y Yamamoto and S Ohnishi. Kochi, Japan Morphological a n a l y s i s of colorectal s u b m u c o s a l c a n c e r s w i t h r e f e r e n c e to t h e i r p r e c u r s o r y lesions. (Abstract# 308) H Mitooka, K Irie, R Kasiwagi, F Tabata and T Fujimori. Kobe, Akasi and Tochigi, Japan U t i l i t y of a side-viewing u p p e r echoendoscope for endoscopic u l t r a s o n o g r a p h y of m a l i g n a n t a n d b e n i g n c o n d i t i o n s of t h e sigmoid colon a n d the r e c t u m . (Abstract# 282) MS Bhutani and P Nadella. Dayton, OH Metallic s t e n t s i n the p a l l i a t i v e t r e a t m e n t of rectal c a n c e r at r e c t o s i g m o i d j u n c t i o n . (Abstract# 292) D Fregonese, F Monica and G Di Falco. Treviso, Italy P a l l i a t i o n of m a l i g n a n t colorectal s t r i c t u r e s with e x p a n d a b l e m e t a l l i c stents: experience w i t h 20 p a t i e n t s . (Abstract# 315) I Raijman, I Siddique, J Skibber, J Ajani, S Lah0ti and P Lynch. Houston, TX Self e x p a n d i n g metallic s t e n t s i n m a l i g n a n t colonic o b s t r u c t i o n - e a r l y experiences w i t h a n e w palliative t r e a t m e n t . (Abstract# 320) F Schreiber, GCH Gurakuqi, M Trauner, W Schnedl and GJ Krejs. Karl, France and Graz, Austria Cross-sectional i m a g i n g of colon c a n c e r a n d u l c e r a t i v e colitis u s i n g optical coherence tomography. (Abstract# 33) K Kobayashi, JA Izatt, MD Kulkarni and MV Sivak, Jr. Cleveland, OH COLITIS AND OTHER COLONOSCOPY

DDW Poster of Distinction: Colonoseopy to e v a l u a t e a b d o m i n a l p a i n i n clinical practice: h o w often is s i g n i f i c a n t n e o p l a s i a found? (Abstract# 301) DA Lieberman, DE Fleischer, GM Eisen, P DeGarmo and M Helfand. Portland, OR; Washington, DC and Memphis, TN Does p r e m e d i c a t i o n w i t h either i n t r a v e n o u s or oral h y o s c y a m i n e facilitate colonoscopy? (Abstract# 321) NJ Shaheen, DJ Robertson, M Crosby, SJ Furs, DT May, WR Harlan, IS Grimm, KL Isaacs and EM Bozymski. Chapel Hill, NC

Usefulness of endoscopic r e t r o g r a d e i l e o g r a p h y i n Crohn's disease - a c o m b i n a t i o n of colonoscopic a n d radiological e x a m i n a t i o n . (Abstract# 326) M Taruishi, Y Saitoh, M Honda, T Fujiki, M Taniguchi, J Warari, T Ayabe, T Ashida, T Obara and Y Kohgo. Asahikawa, Japan F e a s i b i l i t y of m a g n i f i e d colonoscopy for e v a l u a t i o n of a c t i v i t y i n u l c e r a t i v e colitis. (Abstract# 318) Y Saitoh, M Nomura, M Taruishi, M Honda, T Fujiki, A Sasaki, T Ayabe, T Ashida, T Obara and Y Kohgo. Asahikawa, Japan I m p r o v e d outcome of s y m p t o m a t i c C r o h n ' s s t r i c t u r e s with b a l l o o n d i l a t i o n a n d i n t r a l e s i o n a l s t e r o i d injection. (Abstract# 295) DA Howell, BL Hanson and PM Ku. Portland, ME The role of colonoscopy i n t h e diagnosis of acute diverticulitis. (Abstract# 291) AS Farivar, M Farivar and RS Farivar. Norwood and Boston, MA P h o t o d y n a m i c t h e r a p y for m a n a g e m e n t of r e f r a c t o r y h e m o r r h a g i c r a d i a t i o n proctitis. (Abstract# 330) LM WongKeeS0ng, KK Wang and A Nourbakhsh. Rochester, MN P a t i e n t s w i t h r e c u r r e n t GI h e m o r r h a g e a n d colonic a n g i o m a s - a r a n d o m i z e d s t u d y of endoscopic t r e a t m e n t with b i p o l a r or h e a t e r p r o b e coagulation. (Abstract# 304) GA Machicado, DM Jensen, TG Kovacs, R Jutabha, G Randall, J Gornbein, ME Jensen, S Cheng and L Fontana. Los Angeles, CA A prospectively v a l i d a t e d p r e d i c t i v e s c o r i n g system for p a t i e n t s w i t h acute lower g a s t r o i n t e s t i n a l bleeding. (Abstract# 285) FC Byfield, PD Stevens, J Fineg01d, B Diamond, R Gal, RJ Garcia-Carrasquillo and CJ Lightdale. New York, NY P r o s p e c t i v e analysis of w o r k - u p of a c u t e lower g a s t r o i n t e s t i n a l bleeding: c a n a n o p t i m a l algorithm be designed? (Abstract# 314) C Prakash, GR Zuckerman, G Aliperti, DT Walden, HD Royal and JR Willis. St. Louis, MO A r a n d o m i z e d , c o m p a r a t i v e a n i m a l s u r v i v a l s t u d y of colonic t a t t o o i n g u s i n g i n d o c y a n i n e g r e e n or I n d i a i n k . (Abstract# 303) AH Low, JG Lee and JWC Leung. Sacramento, CA E v a l u a t i o n of m o t i l i t y a n d form of ileocecal valve w i t h endoscopic r e t r o g r a d e m a r k e r s i n s e r t i o n method. (Abstract# 306) T Maeda, Y Tsunemura, Y Fukui, Y Imamura, K Kato, S Fujita, H Sato, Y Tatsumi, S Mitsufuji, T Kodama and K Kashima. Kyoto, Japan

P192 P R O G R A M OF THE A N N U A L M E E T I N G i

E N D O S C O P I C T E C H N O L O G Y : EUS, FLUORESCENCE AND SPECTROSCOPIC TECHNOLOGIES E n d o s c o p i c d e t e c t i o n o f a b e r r a n t c r y p t foci b y magnification chromoscopy: a blinded comparison against dissecting microscopy and histology in an e x v i v o model. (Abstract# 61) D Sorbi, LJ Burgart, DA Ahlquist, WE Kames, L Wang, AR Zinsmeister and CJ Gostout. Rochester, MN W a v e l e n g t h a n d b a n d w i d t h of colonic e m i s s i o n s p e c t r a a n d t h e r o l e of b a s e m e n t m e m b r a n e c o l l a g e n a n d elastin. (Abstract# 4) B Banerjee, B Miedema and HR Chandrasekhar. Columbia, MO

GASTROENTEROLOGY Vol, 114, No. 4

A n o n - c o n t a c t m e t h o d for e v a l u a t i n g o x y g e n s a t u r a t i o n of colonic m u c o s a l h e m o g l o b i n - i m a g e p r o c e s s i n g on e n d o s c o p i c p i c t u r e s . (Abstract# 53) Y Sasaki, T Tsuji, Y Uno, R Hada and A Munakata. Hirosaki, Japan Poster Grand Rounds 5:30-6:30 p m Room 80 / 81 Ernest N. Morial Convention Center 5:30 ERCP-Biliary. John Baillie. Durham, NC 5:50 E R C P - P a n c r e a s .

John Baillie. Durham, NC 6:10 E n d o s c o p i c U l t r a s o u n d . Douglas O. Faigel. Lake Oswego, OR

April 1998

P R O G R A M OF T H E ANNUAL MEETING P193

WEDNESDAY, MAY 20, 1998 SOCIETY FOR THE SURGERY OF THE ALIMENTARY TRACT SSAT Business Meeting

7:00-8:15 am

Room 103 / 104 Ernest N. Morial Convention Center

Presentation of the SSAT Founders Medal

8:15-8:30 am

Room 103 / 104 Ernest N. Morial Convention Center

SSAT/SAGES Symposium on Minimally Invasive Surgery

12:00-3:30 p m

SSAT will sponsor a box lunch for participants during the symposium. 12:00

SSAT Scientific Presentations

8:30-10:00 am

Room 103 / 104 Ernest N. Morial Convention Center

Chairs: Thomas DeMeester, Josef Fischer

State of the Art Lecture: P. Chandrasona. Los Angeles, CA

9:00

N e a r t o t a l g a s t r e c t o m y for severe p o s t v a g o t o m y gastroparesis: critical analysis of e a r l y a n d late long t e r m r e s u l t s at a t e r t i a r y center. (Abstract# S0066) AW Forstner-Barthell, MM Murr, S Nitecki, KA Kelly, M Camilleri, CM Prather and MG Sarr. Rochester, MN

9:15

9:30

9:45

Role of a n g i o g r a p h y a n d e m b o l i z a t i o n for a c u t e massive u p p e r g a s t r o i n t e s t i n a l h e m o r r h a g e . (Abstract# S0268) RM Walsh, P Anain, M Geisinger, D Vogt, J Mayes, S Grundfest-Broniatowski and JM Henderson. Cleveland, OH Effect of microscopic r e s e c t i o n line disease on g a s t r i c c a n c e r survival. (Abstract# S0120) SH Kim, MS Karpeh, DS Klimstra, D Leung and MF Brennan. New York, NY

Chair:

Williams Richards

12:30

Minimally invasive intraluminal and t r a n s g a s t r i c surgery. Michel Gagner. Cleveland, OH M i n i m a l l y i n v a s i v e s u r g e r y for p e r f o r a t e d d u o d e n a l ulcer. Steve Eubanks. Durham, NC Laparoscopic vagotomy. Jack Flowers. Baltimore, MD Laparoscopic g a s t r o s t o m y a n d j e j u n o s t o m y . Reid Adams. Charlottesville, VA

1:20

Chair:

Bruce Schirmer

1:50

Laparoscopic g a s t r o j e j u n o s t o m y . David McFadden. Los Angeles, CA Laparoscopic gastric resection. Demitrius Litwin. Boston, MA Laparoscopic v e r t i c a l b a n d e d gastroplasty. James Maher. Iowa City, IA Laparoscopic i n f l a t a b l e g a s t r i c b a n d i n g . Robert McIntyre. Denver, CO

SSAT Scientific Presentations

Room 103 / 104 Ernest N. Morial Convention Center

Chairs: Andrew Warshaw, William Traversa CLINICAL PAPERS VI 10:30 11:15

11:30

11:45

Invited Speaker David Sachs. Boston, MA A p p e n d e c t o m y i n the p r e a n d post l a p a r o s c o p i c eras. (Abstract# S0175) DB Nguyen, W Silen and RA Hodin. Boston, MA Laparoscopic versus open i n g u i n a l h e r n i o r r a p h y . A r a n d o m i z e d controlled trial. (Abstract# S0021) JS Barkun, MJ Wexler, M Fernandez and JL Meakins. Montreal, Canada Force feedback g r a s p e r helps r e s t o r e sense of t o u c h i n m i n i m a l l y i n v a s i v e surgery. (Abstract# S0151) M MacFarlane, J Rosen, B Hannaford, C Pellegrini and M Sinanan. Seattle, WA

Panel Discussion (Drs. Gagner, Eubanks, Flowers, and Adams)

PART TWO

P r e o p e r a t i v e superselective i n t r a - a r t e r i a l c h e m o t h e r a p y for the t r e a t m e n t of unresectable gastric c a r c i n o m a . (Abstract# S0233) IB Shchep0tin, V Ch0rny, L Gooluck and SRT Evans. Washington, DC and Kiev, Ukraine

10:30 am-12:00 p m

Lunch

PART ONE

CLINICAL PAPERS V 8:30

Room 103 / 104 Ernest N. Morial Convention Center

Laparoscopic gastric b y p a s s Phillip Schauer. Pittsburgh, PA 2:50

Panel Discussion

(Drs. McFadden, Litwin, Maher, McIntyre, and Schauer)

P194PROGRAMOFTHEANNUALMEETING

GASTROENTEROLOGYVol.l14tNo.4

THE A M E R I C A N ASSOCIATION FOR THE STUDY OF LIVER D I S E A S E S THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION 1998 F o c u s e d C l i n i c a l / R e s e a r c h U p d a t e s

TOPIC Endoscopic ultrasound Pediatric GI disease H. pylori pathogenesis Cholestatic ulcer disease Diarrheal illnesses; E. coli Peptic ulcer: new insights Viral hepatitis Cytokines Cyclo-oxgenase inhibitors:injury an d healing Gut gene expression Growth factorsand signal transduction

SPEAKER Charles J. Lightdale~ M.D. Jay A. Perman, M.D. David R. Cave, M,D, Ph.D. E. Jenny Heathcote, M.D. Ralph A. Gianella~ M.D., Ph.D. Denis M. McCarthy, M.D, Ph.D. Jay H. Hoofnagle~M.D. Fabio Cominelli, M.D.~ Ph.D. Byron L. Cryer, M.D. Vincent W. Yang, M.D, Ph.D. Daniel K. Podolsky, M.D.

AGA S t a t e o f t h e A r t L e c t u r e 8:30-9:30 am Room 5 8 / 5 9 / 6 0 Ernest N. Morial Convention Center

AGA C l i n i c a l S y m p o s i u m 8:30-10:00 am Room 6 1 / 6 2 / 6 3 Ernest N. Morial Convention Center

Sponsored by Clinical Practice Co-sponsored by Pancreatic Disorders

Sponsored by Motility and Nerve-Gut Interactions Chair:

Chair:

Ronald L. Koretz

Hereditary Pancreatitis: New Insights. David C. Whitcomb. Pittsburgh, PA AGA S t a t e o f t h e A r t L e c t u r e 8:30-9:30 am Room 80/81 Ernest N. Morial Convention Center Sponsored by Biliary Disorders Co-sponsored by Immunology, Microbiology, and Inflammatory Disorders

Chairs: Roger D. Soloway, Peter F. Malet BACTERIA AND BIOFILM: IMPLICATIONS FOR THE BILIARY TRACT Biofilm invades the biliary tract. William Costeron. Bozeman, MT

Stents, sludge, stones. Joseph Leung. Sacramento, CA Panel discussion

AGA S t a t e o f t h e A r t L e c t u r e 8:30-9:30 am Room 99 Ernest N. Morial Convention Center Sponsored by Intestinal Disorders Intestinal bile acid transport: molecules, mechanisms and malabsorption. Paul A. Dawson. Winston-Salem, NC

Michael D. Gershon

PSEUDOOBSTRUCTION: GENES, INTERSTITIAL CELLS, CHANNELS AND SIGNIFICANCE OF BASIC ADVANCES Molecular models: NO, neurotrophic factors and others. Hir0shi Mashimo. Watertown, MA Interstitial cells in pseuboobstruction syndromes. Gianrico Farrugia. Rochester, MN Channels and enteric nerves. James J. Galligan. East Lansing, MI Clinical significance of basic advances. Paul E. Hyman. Orange, CA AGA C l i n i c a l S y m p o s i u m 8:30-10:00 am Room 9 0 / 9 1 / 9 2 Ernest N. Morial Convention Center Sponsored by Clinical Practice Co-sponsored by Biliary Disorders

Chair:

E m m e t Keeffe

MANAGEMENT OF THE PATIENT FOLLOWING LIVER TRANSPLANTATION Immunosuppressive therapy and side effects. Kenneth D. Flora. Portland, OR Rejection versus hepatitis C: Diagnosis and management. Robert L. Carithers. Seattle, WA Fungal, bacterial and opportunistic infections. Susan Orloff. Portland, OR Biliary complications. Michael B. Kimmey. Seattle, WA Management of recurrent hepatitis B and C post transplant. Teresa L. Wright. San Francisco, CA Questions and Answers

A p r i l 1998

P R O G R A M O F T H E A N N U A L M E E T I N G P195

WEDNESDAY, MAY 20, 1998 AGA Clinical Symposium

8:30-10:00 am

I d e n t i f i c a t i o n of a u n i q u e esophageal m o t o r p a t t e r n b y p r o b e u l t r a s o n o g r a p h y : a m a r k e r of s p o n t a n e o u s a n d i n d u c e d esophageal chest pain. (Abstract# G4766) RK Mittal, DH Balaban, Y Yamamoto, J Liu and R Wisniewski. Charlottesville, VA

9:30

I r r i t a b l e bowel s y n d r o m e : p a r a d i g m of p e r t u r b e d b r a i n - g u t i n t e r a c t i o n ? (Abstract# G3335) T Nomura, N Wingate, L Camacho-Lobato and DL Wingate. London, United Kingdom

9:45

Differential effects of n u t r i e n t s on s e n s i t i z a t i o n of p e r c e p t u a l responses to a n t r a l d i s t e n t i o n : role of s e r o t o n i n a n d c h o l e c y s t o k i n i n p a t h w a y s . (Abstract# G3224) U Ladabaum, F H00per, M Woods, C Kelly, M Brown, C Owyang and W Hasler. Ann Arbor, MI

Room 100/101/102 Ernest N. Morial Convention Center

Sponsored by Gastrointestinal Oncology Co-sponsored by Esophageal, Gastric, and Duodenal Disorders Chair:

9:15

Stuart Spechler

CANCER R I S K IN BARRETT'S E S O P H A G U S Epidemiology and mechanisms Alan J. Cameron. Rochester, MN Screening and surveillance Stuart J. Spechler. Dallas, TX Endoscopic treatment Charles J. Lightdale. New York, NY

AGA R e s e a r c h S y m p o s i u m 8:30-10:00 am Room 33/35 Ernest N. Morial Convention Center

Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum

8:30-10:00 am

Sponsored by Gastrointestinal Oncology Chair:

Randall W. Burt

BIOLOGIC BASIS OF COLORECTAL CANCER RISK What does t h e APC p r o t e i n do? Patrice Morin. Baltimore, MD

Chairs: Derek P. Jewell, Theodore A. Bayless IBD GENETICS 8:30

HLA genes are i m p o r t a n t p h e n o t y p e d e t e r m i n i n g genes i n t h e p e r i p h e r a l a r t h r o p a t h i e s of i n f l a m m a t o r y bowel disease. (Abstract# G4321) TR Orchard, S Thiyagaraja, KI Welsh, BP Wordsworth and DP Jewell. Oxford, United Kingdom

8:45

HLA d i s p a r i t y d e t e r m i n e s disease a c t i v i t y t h r o u g h p r e g n a n c y i n w o m e n with IBD. (Abstract# G4121) S Kane, S Hanauer, J Kiesel, L Shih and D Tygan. Chicago, IL and Los Angeles, CA

9:00

L i n k a g e a n d association b e t w e e n Crohn's disease a n d a p u t a t i v e locus o n chromosome 12. (Abstract# G4581) H Yang, JD Ohmen, R Ma, Z Li, LG Bentley, SR Targan, N Fischel-Ghodsian and JI Rotter. Los Angeles and Alameda, CA

9:15

F i n e m a p p i n g of the i n f l a m m a t o r y bowel disease s u s c e p t i b i l i t y locus I i n the p e r i c e n t r o m e r i c r e g i o n of chromosome 16. (Abstract# G4093) JP Hugot, H Zouali, JF Colombel, J Belaiche, JP C~zard, M Peeters, A Van Gossum, R LSfberg, F Pallone, C Gower-Rousseau, JP Gendre, G Thomas, the GETAID, Registre EPIMAD and the European Concerted Action on the Genetics of Inflammatory Bowel Disease. Paris and Lille, France; Liege, Leuven and Brussels, Belgium; Huddinge, Sweden and Catanzaro, Italy

9:30

P r e c i s i o n m a p p i n g of c h r o m o s o m e 12 l i n k a g e i n IBD: evidence for a h a p l o t y p e association. (Abstract# G4332) M Parkes, J Satsangi, A Merriman and DP Jewell. Oxford, United Kingdom

9:45

A genome wide screen of Crohn's disease i n a large pedigree shows evidence for linkages to chromosomes 11, 16, 8 a n d 15. (Abstract# G3856) SR Brant, D Nicolae, MC LaBuda, R Baltazar, C Fields, G Ravenhill, M Pickles, PM Rohal, EW Jabs, SB Hanauer, TM Bayless and JH Cho. Baltimore, MD and Chicago, IL

F u n c t i o n s of DNA m i s m a t c h r e p a i r proteins; I m p l i c a t i o n s for carcinogenesis. Thomas Kunkel. Research Triangle Park, NC Colorectal c a n c e r s u s c e p t i b i l i t y polymorphisms. Rashmi Sinha. Salt Lake City, UT Hormones, Transmitters, Growth Factors and Their Receptors AGA Research Forum

8:30-10:00 am

Room 11 Ernest N. Morial Convention Center

Chairs: Lionel Budno, Ronald P. Fogel VISCERAL P A I N 8:30

A l t e r e d cortical a n d subcortical b r a i n a c t i v a t i o n associated w i t h a u t o n o m i c r e s p o n s e s to visceral p a i n i n i r r i t a b l e bowel s y n d r o m e . (Abstract# G4773) J Munakata, DHS Silverman, B Naliboff, M Liu, L Chang, M Mandelkern and EA Mayer. Los Angeles, CA

8:45

A n e w visceral nociceptive p a t h w a y i n the dorsal column: anatomical and functional s t u d i e s of p a n c r e a t i c p a i n i n c l u d i n g the effects of l i m i t e d dorsal c o l u m n lesions i n rats. (Abstract# G4855) C-C Wang, Y Lu, J Winston, PJ Pasricha and KN Westlund. Galveston, TX

9:00

Q u a n t i t a t i v e basis for t h e dorsal c o l u m n d o m i n a n t role i n visceral p a i n i n the p r i m a t e . (Abstract# G4601) ED A1-Chaer, Y Feng and WD Willis. Galveston, TX

Room 1 3 / 1 5 / 1 7 Ernest N. Morial Convention Center

P196 PROGRAM OF THE ANNUAL MEETING

Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum

8:30-10:00 am

GASTROENTEROLOGY Vol. 114~ No. 4

8:45

The effect of t h e r e c o m b i n a n t B s u b u n i t of cholera t o x i n o n a n t i g e n p r o c e s s i n g b y h u m a n i n t e s t i n a l e p i t h e l i a l cells. (Abstract# G4070) R Hershberg, P Framson and J Petersen. Seattle, WA

9:00

M o u s e s t r a i n s r e s i s t a n t a n d s u s c e p t i b l e to Helicobacter hepatieus~related h e p a t i t i s differ i n systemic i m m u n e r e s p o n s e to e x p e r i m e n t a l infection. (Abstract# G4554) MT Whary and JG Fox. Cambridge, MA

9:15

Oral i m m u n i z a t i o n of ferrets w i t h Helicobaeter pylorivaccine c o n s t r u c t s decreases endoscopic a n d histologic H. mustelae~associated disease

Room 19 Ernest N. Morial Convention Center

Chairs: Cox Terhorst, Stephen M. Collins ANIMAL MODELS OF IBD: P A T H O G E N E S I S 8:30

A n o v e l a p p r o a c h to i d e n t i f y epithelial defense m e c h a n i s m s a g a i n s t n o r m a l l u m i n a l bacteria. (Abstract# G4314) H Ogawa, K Fukushima, I Sasaki, H Naito, Y Funayama, T Masuko, K Takahashi, S Satoh, T Ueno, A Hashimoto and S Matsuno. Sendai, Japan

8:45

C h a r a c t e r i z a t i o n of a n e w s p o n t a n e o u s m u r i n e model of i n f l a m m a t o r y bowel disease. (Abstract# G4143) MM Kosiewicz, A Krishnan, M Shah, M Bentz, C Nast, S Matsumoto and F Cominelli. Charlottesville, VA; Los Angeles, CA and Tokyo, Japan

9:00

Efficient h o m i n g of CD4+ cells to t h e gut m u c o s a is n e c e s s a r y for colitis pathogenesis, b u t m a y n o t be r e q u i r e d for t h e d o w n r e g u l a t i o n of p a t h o g e n i c T cells. (Abstract# G4485) BC Syd0ra, G Yakoub, N Wagner, W MueUer, M Kronenberg and R Aranda. Los Angeles and San Diego, CA; Cologne, Germany

9:15

9:30

9:45

The role of CD40L i n two T cell i n d u c e d models of e x p e r i m e n t a l colitis. (Abstract# G3940) YP de Jong, M Comiskey and C Terhorst. Boston, MA Mice w i t h d e c r e a s e d E-, P- a n d L-selectin l i g a n d b i o s y n t h e s i s are m o r e r e s i s t a n t to d e x t r a n s o d i u m s u l f a t e - i n d u c e d colitis b u t h a v e more severe TNBS colitis. (Abstract# G4569) RJ Xavier, PL Beck, N Lu, DK Podolsky and B Seed. Boston, MA Anti-IL-4 a n t i b o d y t r e a t m e n t p r e v e n t s the i n d u c t i o n of i n f l a m m a t o r y bowel disease i n T cell r e c e p t o r a l p h a c h a i n - d e f i c i e n t (a 4") mice b y s u p p r e s s i n g the effect of TH2 p r e d o m i n a t e d CD4 ÷ TCR ~dimT cells. (Abstract# G4099) H Iijima, I Takahashi, S Kawano, K Nagano, M Hori and H Kiyono. Osaka, Japan

Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum

8:30-10:00 am

a n d b a c t e r i a l load. (Abstract# G4301) GW Newman, B Williams, D Adams, D Ngo, B Khanna, L Herman and BD Gold. Atlanta, GA and Washington, DC 9:30

Gastric p a r i e t a l cell a n t i b o d i e s are associated w i t h a n a l t e r e d d i s t r i b u t i o n of Helieobaeter pylori i n f e c t i o n a n d i n c r e a s e d b o d y atrophy. (Abstract# G4412) V Saxena, M Asante, MA Mendall, N Neira, AM Zaitoun and TC Northfield. London and Surrey, United Kingdom

9:45

Differential r a t e s of loss of m u c o s a l HIV genomic RNA a n d mRNA d u r i n g c o m b i n a t i o n a n t i r e t r o v i r a l therapy. (Abstract# G4372) S Reka. New York, NY

Growth, Development, Nutrition AGA Research Forum

8:30-10:00 am

Chairs: Vincent Wen-Shan Yang, Gary D. Wu GUT GENE EXPRESSION 8:30

Three d i s t i n c t mRNA d i s t r i b u t i o n p a t t e r n s i n h u m a n j e j u n a l enterocytes. (Abstract# G3656) W Li, SD Krasinski, M Verhave, RK Montgomery and RJ Grand. Boston, MA

8:45

D i f f e r e n t i a t i o n of CaCo-2 i n t e s t i n a l cells is associated w i t h G 1 a r r e s t a n d s u p p r e s s i o n of c y c l i n - d e p e n d e n t kinase. (Abstract# G3584) Q-m Ding, TC Ko and BM Evers. Galveston, TX

9:00

Selective k i l l i n g of P a n e t h cells i n d u c e d t r a n s i e n t wave of epithelial p r o l i f e r a t i o n i n the e n t i r e i n t e s t i n a l crypts. (Abstract# G3717) M Sawada, N Miyake, S Takaishi, Y M0rita, H Hiai and T Chiba. Kyot0, Japan

9:15

P o s t n a t a l Kit e x p r e s s i o n i n t h e i n t e s t i n e of mice deficient i n i n t e r s t i t i a l cells of Cajal s t u d i e d b y t h e t r a n s g e n i c WlacZ r e p o r t e r gene mode. (Abstract# G3741) J-M Vanderwinden, F Bernex and J-J Panthier. Brusselles, Belgium and Maisons-Alfort, France

9:30

In vivo r e g u l a t i o n of g u a n y l i n gene expression.

Room 44 Ernest N. Morial Convention Center

Chairs: Edgar C. Boedeker, Michael J.G. Farthing MUCOSAL R E S P O N S E TO E N T E R I C I N F E C T I O N S 8:30

A t t e n u a t e d Shigella as vectors for foreign a n t i g e n delivery: effect of v i r G m u t a t i o n s p r e v e n t i n g cell to cell s p r e a d o n sytemic a n d m u c o s a l i m m u n e responses. (Abstract# G3831) P Bloom, R Russell, D Blake, T B0wen, F Noriega, E Boedeker, M Le and W Brown. Baltimore, MD and Denver, CO

Room 82/83 Ernest N. Morial Convention Center

(Abstract# G3609) P Goday, J Hochman, M Pontoglio, D Witte and MB Cohen. Cincinnati, OH and Paris, France 9:45

Activation of the h u m a n d i p e p t i d y l p e p t i d a s e IV gene b y h e p a t o c y t e n u c l e a r factor-1 i n CaCo-2 cells. (Abstract# G3599) RH Erickson, JR Gum, CD Lotterman, JW Hicks and YS Kim. San Franciso, CA

Aprn199S

PROGRAM OF THE ANNUAL MEETING P197

WEDNESDAY, MAY 20, 1998 Esophageal, Gastric, and Duodenal Disorders AGA Research Forum 8:30-10:00 am Room 85/86 Ernest N. Morial Convention Center

8:45

Molecular m e c h a n i s m of g r o w t h i n h i b i t i o n b y a RAR a-selective r e t i n o i c acid i n p a n c r e a t i c c a n c e r cell lines. (Abstract# G1871) K Fujimoto, R Hosotani, R Doi, M Wada, J-U Lee, T Koshiba, Y Miyamoto, S Tsuji, S Nakajima and M Imamura. Kyoto, Japan

Chairs: Alan F. Cutler, Hartley Cohen

9:00

C u l t u r e of coccoid Helleobaeterpylori. (Abstract# G1347) I Wendelin, HF Hammer, EC Reisinger, AJ Eherer and GJ Krejs. Graz, Austria

ERK-2 a n d p38 MAP k i n a s e are m e d i a t o r s of PANC-1 a n d MIAPaCa-2 r e s p e c t i v e growth; p r e s e n c e of a " c o n s t i t u t i v e "ERK-1 activity. (Abstract# G1847) N Douziech, E Calvo, J Lain6 and J Morisset. Sherbrooke, Canada

9:15

A six-year a s s e s s m e n t of tinidazole, metronidazole, clarithromycin, tetracycline a n d a m o x i c i l l i n r e s i s t a n c e i n Helieobaeter pylori c l i n i c a l isolates - a r i s i n g tide of a n t i b i o t i c r e s i s t a n c e ? (Abstract# G0960) D Morton and KD Bardhan. Rotherham, United Kingdom

C o n s t i t u t i v e a c t i v a t i o n of p70 sek i n h u m a n p a n c r e a t i c c a n c e r cell lines b e a r i n g a c t i v a t i n g KI-ras m u t a t i o n s . (Abstract# G2023) T Seufferlein, M Grewe, G Adler and R Schmid. Ulm, Germany

9:30

T r y p s i n o g e n m u t a t i o n s of exons 2 a n d 3 i n h e r e d i t a r y a n d c h r o n i c alcoholic p a n c r e a t i t i s . (Abstract# G1925) V Keim, N Teich, A Reich and J M6ssner. Leipzig, Germany

9:45

C e r u l e i n activates NF-KB a n d AP-1 i n isolated p a n c r e a t i c a c i n a r cells. (Abstract# G1890) I Gukovsky, AS Gukovskaya and SJ Pand01. Los Angeles, CA

HELICOBACTER PYLORI: ANTIMICROBIAL RESISTANCE 8:30

8:45

9:00

Effect of a m o x i c i l l i n r e s i s t a n c e on the t h e r a p y of Helleobaeterpyloriinfection. (Abstract# G0446) MP Dote, A Piana, M Carta, A Atzei, BM Are, I Mura, G MassareUi, A Maida, G Realdi, AR Sepulveda and DY Graham. Sassari, Italy and Houston, TX PBP-D, a n o v e l p e n i c i l l i n - b i n d i n gprotein, is involved in amoxicillin resistance in Helicobaeterpylori. (Abstract# G0447) MP Dote, DY Graham and AR Sepulveda. Houston, TX

9:15

9:30

D e v e l o p m e n t of c l a r i t h r o m y c i n r e s i s t a n c e is 2.7 times less likely w i t h r a n i t i d i n e b i s m u t h c i t r a t e t h a n w i t h omeprazole. (Abstract# G1022) M Osato, DY Graham, N Vakil, SH Gordon, CS Kleoudis, MT Silver and RH Murdock. Houston, TX; Milwaukee, WI and Research Triangle Park, NC

Gastrointestinal Oncology AGA Research Forum

8:30-10:00 am

Chairs: James A. DiSario, Stephen J. Lanspa EXPERIMENTAL T H E R A P E U T I C S 8:30

Photodynamic therapy with 5-aminolaevulinic acid for t h e t r e a t m e n t of d y s p l a s i a a n d early c a r c i n o m a i n t h e u p p e r GI tract. (Abstract# G2936) T Zoepf, G Preclik, W Boeck, A Rueck, JF Riemann and G Adler. Ulm and Ludwigshafen, Germany

8:45

I n f l u e n c e of e r y t h r o p o i e t i n o n t r a n s f u s i o n requirements in patients receiving p r e o p e r a t i v e c h e m o r a d i o t h e r a p y for rectal cancer. (Abstract# G2885) S Vijayakumar, C Laborde, C McKnight and EA Levine. New Orleans, LA and Chicago, IL

9:00

Inhibition of angiogenesis by cyclooxygenase-2 inhibitors suppresses the growth of gastric cancer xenograft i n n u d e mice. (Abstract# G2776) H Sawaoka, S Kawano, S Tsuji, M Tsujii, ES Gunawan, H Murata and M Hori. Suita, Japan

9:15

Targeted chemotherapy with encapsulated, genetically modified cells e n g i n e e r e d to p r o d u c e CYP2B1, a n ifosfamide c o n v e r t i n g enzyme. (Abstract# G2672) P Mtiller, P Karle, R Jesnowski, R Saller, S Mitzner, J Stange, S Liebe, B Salmons, WH Giinzburg and M L6hr. Rostock and Munich, Germany; Vienna, Austria

9:30

A t t e n u a t e d HSV-1 kills h u m a n p a n c r e a t i c cancer cells in ~itro. (Abstract# S0137) JH Lee, HJ Federoff, JL Peacock and LO Schoeniger. Rochester, NY

9:45

Differential sensitivity of p a n c r e a t i c cancer cells to farnesyl transferase i n h i b i t o r correlates with altered subcellular Ras d i s t r i b u t i o n a n d G2/M cell cycle arrest. (Abstract# G2818) SY Song, N Sizemore, I Meszoely, RJ Coffey and SD Leach. Nashville, TN

R e d u c e d r i s k of c l a r i t h r o m y c i n - r e s i s t a n t H.

pylorg w i t h a m o x i c i l l i n cotherapy: r e s u l t s from t h r e e m u l t i c e n t e r d o u b l e - b l i n d U.S. trials. (Abstract# G0793) L Laine, L Suchower, A Connors, J Frantz and G Neff. Los Angeles, CA and Wayne, PA 9:45

Direct d e t e c t i o n of r e s i s t a n c e of Helicobacter pylori to m a c r o l i d e s b y PCR/DEIA i n gastric biopsies. (Abstract# G0879) A Marais, M Pina, L Monteiro, H Lamouliatte and F M~graud. Bordeaux, France

Pancreatic Disorders AGA Research Forum

8:30-10:00 am

Room 88 Ernest N. Morial Convention Center

Chairs: Fred S. Gorelick, Manfred P. Lutz MOLECULAR PANCREATOLOGY 8:30

Bi-allelic i n a c t i v a t i o n of the BRCA2 gene occurs after K-ras m u t a t i o n s i n p a n c r e a t i c p r e c u r s o r lesions from p a t i e n t s with g e r m l i n e BRCA2 m u t a t i o n s . (Abstract# G1881) M Goggins, RH Hruban and SE Kern. Baltimore, MD

Room 89 Ernest N. Morial Convention Center

GASTROENTEROLOGY Vol. 114, No. 4

P198 P R O G R A M OF T H E ANNUAL MEETING

WEDNESDAY, MAY 20, 1998 Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum 8:30-10:00 a m Room 93/94 E r n e s t N. Morial Convention Center

8:45

Oxidative stress i n d u c e s t y r o s i n e phosphorylation and membrane transloeation of pp60 c'src a n d pp125 FAKi n CaCo-2 cell monolayers. (Abstract# G1534) A Gupta and RK Rao. Charleston, SC

9:00

Gene e x p r e s s i o n i n r e s p o n s e to ischemiar e p e r f u s i o n i n r a t i n t e s t i n e . (Abstract# G1771) KY Yah, M Yeh, DN Granger and J Glass. Shreveport, LA

9:15

Mast cell m e d i a t o r release i n r e s p o n s e to s u b s t a n c e P i s associated w i t h stem cell factord e p e n d e n t u p r e g u l a t i o n of Gai.2 a n d Gal.3 proteins and downstream signaling through a protein kinase C-dependent pathway. (Abstract# G1540) LM Higuchi, L Lu, RE Williams and BK Wershil. Boston, MA

9:30

Release of p r o i n f l a m m a t o r y c h e m o k i n e s from model i n t e s t i n a l epithelia is i n h i b i t e d b y l i p o x i n A4 analogs. (Abstract# G1519) A Gewirtz, B McCormick, AS Neish, NA Petasis, K Gronert, CN Serhan and JL Madara. Boston, MA and Los Angeles, CA

9:45

I n d u c i b l e n i t r i c oxide s y n t h a s e depresses n e u r a l l y evoked chloride s e c r e t i o n i n TNBSi n d u c e d colitis i n the mouse. (Abstract# G1607) WK MacNaughten, SS Lowe and K Cushing. Calgary, Canada

Chairs: A s h e r Kornbluth, E. J a n Irvine NATURAL HISTORY OF IBD 8:30

Risk of l y m p h o m a i n i n f l a m m a t o r y bowel disease: a p o p u l a t i o n - b a s e d estimate. (Abstract# G4195) EV Loftus, Jr, WJ Sandborn, WJ Tremaine, WS Harmsen and AR Zinsmeister. Rochester, MN

8:45

I n f l u e n c e of s m o k i n g h i s t o r y o n disease course i n u l c e r a t i v e colitis. (Abstract# G4566) DM Woseth and SB Hanauer. Chicago, IL

9:00

9:15

Clinical, biological a n d histological p a r a m e t e r s as predictors of relapse in u l c e r a t i v e colitis: g e n d e r differences. (Abstract# G3827) A Bitten, MA Peppercorn, D Ant0nioli, JL Nfles, S Shah, A Bousvaros, BJ Ransil, G Wild, A Cohen and AC Stevens. Boston, MA and Montreal, Canada Disease o u t c o m e i n a n i n c e p t i o n cohort of 595 patients in the European collaborative study o n IBD. (Abstract# G4562) J Witte, S Shivananda, J Lennard-Jones, E Monteiro, S Odes, N Tsianos, Y Mouzas, G Fornaciari, R Stockbriigger, V Ruiz Ochoa, E Van Wijlick and M Russel. Maastricht, The Netherlands; London, United Kingdom; Lisbon, Portugal; Soroka, Russia; Ioannina, Greece; Heraklion, Crete and Reggio Emilia, Italy

9:30

C o n c u r r e n t i n f l a m m a t o r y bowel disease a n d m y e l o d y s p l a s t i c s y n d r o m e s . (Abstract# G4063) GC Harewo0d, EV Loftus, Jr, WJ Sandborn and WJ Tremaine. Rochester, MN

9:45

Ileocecal r e s e c t i o n is associated w i t h a d e c r e a s e d i n c i d e n c e of a r t i c u l a r complications i n C r o h n ' s disease. (Abstract# G4322) TR Orchard and DP Jewell. Oxford, United Kingdom

Motility and Nerve-Gut Interactions AGA Research Forum 8:30-10:00 a m Room 97/98 Ernest N. Morial Convention Center

Chairs: D a v i d Grundy, Jackie D. Wood I D E N T I F I C A T I O N AND P R O J E C T I O N OF D E F I N E D NEURONS 8:30

I d e n t i f i c a t i o n a n d c h a r a c t e r i z a t i o n of i n t r i n s i c s e n s o r y n e u r o n s of the s u b m u c o s a l plexus. (Abstract# G3358) H Pan and MD Gershon. New York, NY

8:45

D i s t r i b u t i o n a n d actions of o r p h a n i n i n r a t g a s t r o i n t e s t i n a l tract. (Abstract# G3470) T Takahashi, D Bagnol, A Yazdani, Y Li, SJ Watson and C Owyang. Ann Arbor, MI

9:00

Pyloric d y s f u n c t i o n of i n h i b i t o r y n e u r o t r a n s m i s s i o n i n k n o c k o u t mice l a c k i n g n e u r o n a l n i t r i c oxide synthase. (Abstract# G3286) H Mashimo, X-D He and RK Goyal. West Roxbury and Boston, MA

9:15

P r o j e c t i o n s of n e u r o n s m e d i a t i n g n o n c h o l i n e r g i c fast e x c i t a t o r y s y n a p t i c p o t e n t i a l s i n m y e n t e r i c plexus of g u i n e a pig ileum. (Abstract# G3240) KJ LePard and JJ GaUigan. East Lansing, MI

9:30

Subsets of e n t e r i c n e u r o n s are m a r k e d b y t h e differential expression of K ÷ c h a n n e l s u b u n i t s . (Abstract# G3205) A Kirchgessner and M-T Liu. New York, NY

9:45

S u s t a i n e d increases of e x c i t a b i l i t y of g u i n e a pig m y e n t e r i c AH n e u r o n s following t h e i r s y n a p t i c activation. (Abstract# G3032) N Clerc, JB Furness, WAA Kunze, EA Thomas, PP Bertrand and CJ Aiguier. Marseille, France and Parkville, Australia

Intestinal Disorders AGA Research Forum 8:30-10:00 a m Room 95/96 E r n e s t N. Morial Convention Center

Chairs: M a t t h e w B. Grisham, M a r k J.S. Miller INFLAMMATORY AND I M M U N E E F F E C T S ON INTESTINAL FUNCTION 8:30

• Clostridium difficile toxins A a n d B r e s u l t i n selected m o v e m e n t of t i g h t j u n c t i o n associated p r o t e i n s from t h e m e m b r a n e . (Abstract# G1644) A Nusrat, C yon Eichel-Streiber, JR Turner, CA Parkos, DK Carnes and JL Madara. Atlanta, GA; Mainz, Germany and Detroit, MI

Apri11998

P R O G R A M O F THE ANNUAL M E E T I N G P199

WEDNESDAY, MAY 20, 1998 AGA C l i n i c a l S y m p o s i u m 8:30-10:00 am Ballroom A / B Ernest N. Morial Convention Center

AGA Clinical S y m p o s i u m 10:30 am-12:OO p m Room 6 1 / 6 2 / 6 3 Ernest N. Morial Convention Center

Co-sponsored by Public Affairs and Advocacy Committee, Clinical Practice/Practice Economics Committee, Clinical Practice

Sponsored by Hormones and Receptors Co-sponsored by Motility and Nerve-Gut Interactions

FRAUD AND ABUSE R U L E S AND THE PRACTICING GASTROENTEROLOGIST Title TBA. Lewis Morris, Esq. Washington, DC Compliance. Sanford Teplitzki, Esq. Baltimore, MD P a t h audits. Robert Dickler. Washington, DC

AGA S t a t e o f t h e A r t L e c t u r e 10:30-11:30 am Room 58 / 59 / 60 Ernest N. Morial Convention Center S p o n s o r e d b y Clinical P r a c t i c e Co-sponsored by Immunology, Microbiology a n d

Chair:

Rodger A. Liddle

SOMOATOSTATIN ANALOGUES: R E C E N T ADVANCES IN CLINICAL U S E Established a n d possible use of t h e s o m a t o s t a t i n analogues i n i m a g i n g a n d o t h e r conditions. Robert T. Jensen. Bethesda, MD Development a n d use of s o m a t o s t a t i n analogues for receptor-targeted radiotherapy. Eric P. Krenning. Rotterdam, The Netherlands Use of s o m a t o s t a t i n a n a l o g u e s a l o n e or with o t h e r agents to control v a r i c e a l bleeding. Arun J. Sanyal. Richmond, VA

Inflammatory Disorders and Intestinal Disorders and Motility and Nerve-Gut Interactions

AGA C l i n i c a l S y m p o s i u m 10:30 am-12:OO p m Room 100/101/102 Ernest N. Morial Convention Center

Chair:

Sponsored by Immunology, Microbiology, and Inflammatory Disorders

William N. Katkov

I n f e c t i o n s D i a r r h e a s : A F u t u r e Perspective. Michael Osterholm. Minneapolis, MN AGA State of the Art Lecture

10:30-11:30 am

Room 93/94 Ernest N. Morial Convention Center

Sponsored by Esophageal, Gastric, and Duodenal Disorders Co-sponsored by Growth, Development, and Nutrition and Hormones and Receptors Chair:

Andrew Tarnawski

Trefoil G r o w t h P e p t i d e s i n GI T r a c t Physiology a n d Pathology. Daniel K. P0dolsky. Boston, MA

AGA S t a t e o f t h e A r t L e c t u r e 10:30-11:30 am Room 97/98 Ernest N. Morial Convention Center Sponsored by Motility and Nerve-Gut Interactions Co-sponsored by Hormones and Receptors Chair:

Michael Gershon

A c t i v a t i o n of E x t r i n s i c S e n s o r y Nerves of the Bowel. David Grundy. Sheffield, England

Chair:

William J. Tremaine

DIAGNOSIS, P R E V E N T I O N AND T R E A T M E N T OF STEROID-INDUCED BONE D I S E A S E P a t h o p h y s i o l o g y of s t e r o i d - i n d u c e d metabolic b o n e disease. Steve V. Goldring. Boston, MA Diagnosis a n d m o n i t o r i n g of m e t a b o l i c bone disease i n i n f l a m m a t o r y bowel disease. Paul D. Miller. Lakewood, CO P r e v e n t i o n a n d t r e a t m e n t of s t e r o i d - r e l a t e d bone disease i n i n f l a m m a t o r y bowel disease. Daniel T. Baran. W0rster, MA

AGA R e s e a r c h S y m p o s i u m 10:30 am-12:00 p m Room 80/81 Ernest N. Morial Convention Center Sponsored by Biliary Disorders Chairs: Hans Fromm, Thomas Brasitus BILE ACIDS AND T H E CELL Bile acids n o t just a detergent. Joanne M. Donovan. West Roxbury, MA Bile acids a n d cell death. Gregory J. Gores. Rochester, MN Bile acids & genes. Clifford Steer. Minneapolis, MN P a n e l discussion.

P200 P R O G R A M OF THE ANNUAL MEETING

GASTROENTEROLOGY Vol. 114 r No. 4

WEDNESDAY, MAY 20, 1998 AGA Topic Forum

10:30 am-12:00 p m

U:00

High-resolution colonoscopy a n d chromoendoscopy for classifying colonic polyps: final results of a m u l t i c e n t e r study. (Abstract# G2558) CY Kim, DE Fleischer, RA K0zarek, DL CarrLocke, TCM Li, CJ G0st0ut, SJ Heller, EA Montgomery, FH A1-Kawas, MI Avigan, GM Eisen, JH Lewis and SB Benjamin. Washington, DC; Seattle, WA; Boston, MA; Rochester, MN and Charleston, SC

11:15

Poor interobserver agreement and low specificity of virtual colonoscopy. (Abstract# G2731) P Pescatore, T Glucker, J Delarive, R Meuli, P Schnyder, AL Blum and G D0rta. Lausanne, Switzerland

11:30

Magnetic resonance cholangiography compared to ultrasonography i n patients with suspected biliary and pancreatic diseases. (Abstract# G2261) Z Younes, T Magnuson and F Regan. Baltimore, MD

11:45

M e a s u r e m e n t of gastric p e r f u s i o n u s i n g s c a n n i n g laser D o p p l e r f l o w m e t r y a n d intral u m i n a l gas t o n o m e t r y d u r i n g e s o p h a g e c t o m y . (Abstract# G0322) NH Boyle, WJ Owen, AC Pearce, DN Hunter and RC Mason. London, United Kingdom

Room 11 Ernest N. Morial Convention Center

Chairs: Robert S. Sandler, Robert E. Schoen E P I D E M I O L O G Y OF GI DISEASE 10:30

Digestive c o m p l a i n t s i n the U n i t e d States a n a t i o n a l survey. (Abstract# G0159) RS Sandler, WF Stewart, JN Liberman, JA Ricci and NL Zorich. Chapel Hill, NC; Towson, MD and Cincinnati, OH

10:45

N a t u r a l h i s t o r y of reflux, d y s p e p s i a and i r r i t a b l e bowel over 7 y e a r s in the general p o p u l a t i o n . (Abstract# G0004) L Agreus, NJ Talley, K Sv~irdsudd, O Nyr~n, G Tibblin and MP Jones. Uppsala and Stockholm, Sweden; Sydney, Australia

11:00

E x p o s u r e to r i s k factors for u l c e r a t i v e c o l i t i s occurs d u r i n g a n e a r l y p e r i o d of life. (Abstract# G0038) F Delc5 and A Sonnenberg. Albuquerque, NM

11:15

D i e t a r y factors affecting t h e p r e v a l e n c e of distal colorectal a d e n o m a s and m e t a p l a s t i c polyps. (Abstract# G2898) MA Watson, C Macklin, T Cecil, S Bingham and W Atkin. Norwich, Leeds, Portsmouth, Cambridge and London, United Kingdom

11:30

11:45

Body size, i n c r e a s e d blood glucose a n d i n s u l i n , and colorectal cancer. (Abstract# G2784) RE Schoen, LK KuUer, C Tangen, G Burke, R Tracy, A Dobs and P Savage. Pittsburgh, PA; Seattle, WA; Winston-Salem, NC; Burlington, VT and Baltimore, MD H i g h energy, fat a n d p r o t e i n i n t a d e are risk factors for colorectal c a n c e r b u t n o t in p a t i e n t s w i t h a family h i s t o r y of colorectal cancer. (Abstract# G2430) RC Evans, D Ashby, A Hackett, E Williams and JM Rhodes. Liverpool, United Kingdom

Immunology, Microbiology, and Inflammatory Disorders AGA Research Forum

10:30 am-12:00 p m

Chairs: R. Balfour Sartor, Fabio Cominelli ANIMAL MODELS OF IBD: T R E A T M E N T 10:30

Molecular m e c h a n i s m of i n t e r l e u k i n - l l in the HLA-B27 r a t model of i n f l a m m a t o r y bowel disease. (Abstract# G4341) RL Peterson, L Wang, LM Albert, JC Keith and AJ Dorner. Andover, MA

10:45

An OX40 fusion p r o t e i n p r e v e n t s colitis i n mice. (Abstract# G4076) LM Higgins, SAC McDonald, JG Shields, J Timans, N Whittle and TT MacDonald. London and Cambridge, United Kingdom

11:00

Blockade of CD44 v a r i a n t exon v7 p r e v e n t s e x p e r i m e n t a l colitis. (Abstract# G4564) BM Wittig, U Giinthert and M ZSller. Heidelberg, Germany and Basel, Switzerland

11:15

R e c o m b i n a n t factor XIII a n d e x p e r i m e n t a l colitis i n rats: i m m u n o h i s t o c h e m i c a l e v i d e n c e for tissue enzyme location. (Abstract# G3931) G D'Argenio, V Cosenza, A Grossmann, KH Sprugel, N Della Valle, G Mazzacca, CE Hart and PD Bishop. Naples, Italy and Seattle, WA

11:30

T r e a t m e n t of e x p e r i m e n t a l colitis t h r o u g h i n d u c t i o n of oral t o l e r a n c e t o w a r d s colitise x t r a c t e d proteins. (Abstract# G4100) Y Ilan, S Weksler-Zangen, S Ben-Horin, M Sestiere, J Diment, B Sauter, NR Chowdhury, JR Chowdhury and E Goldin. Jerusalem, Israel and New York, NY

11:45

Selective versus b r o a d s p e c t r u m a n t i b i o t i c s in the p r e v e n t i o n a n d t r e a t m e n t of e x p e r i m e n t a l colitis i n two r o d e n t models. (Abstract# G4367) HC Rath, M Schultz, LA Dieleman, F Li, H K~lbl, W Falk, J SchSlmerich and RB Sartor. Chapel Hill, NC and Regensburg, Germany

AGA Topic Forum

10:30 am-12:00 p m

Room 1 3 / 1 5 / 1 7 Ernest N. Morial Convention Center

Chairs: Robert C. Kurtz, Philip O. Katz E M E R G I N G DIAGNOSTIC MODALITIES IN GASTROENTEROLOGY 10:30

10:45

Fiber-optic d e t e c t i o n of low grade dysplasia in p a t i e n t s w i t h Barrett's e s o p h a g u s u s i n g reflectance spectroscopy. (Abstract# G1337) MB Wallace, SJ Shields, LT Perelmen, B Backman, G Zonios, R Manoharan, K Badizadegan, A Nusrat, M Seiler, T Hamano, I Itzkan, C Lima, M Fitzmaurice, JM Crawford, J Van Dam and MS Feld. Boston, MA and Cleveland, OH L i g h t - i n d u c e d f l u o r e s c e n c e endoscopy for the in vivo d e t e c t i o n of colorectal dysplasia, (Abstract# G2494) J Haringsma and GNJ Tytgat. Amsterdam, The Netherlands

Room 19 Ernest N. Morial Convention Center

Apri11998

PROGRAM OF THE ANNUAL MEETING P201

WEDNESDAY, MAY 20, 1998 Gastrointestinal Oncology AGA Research Forum

10:30 am-12:00 p m

11:00

of n o n - p e p t i d e l i g a n d s to activate t h e c h o l e c y s t o k i n i n - B / g a s t r i n receptor. (Abstract# G4614) M Beinborn, M Bl~ker, K Schaffer, LK DeMeo, C Chen and AS Kopin. Boston, MA

Room 33/35 Ernest N. Morial Convention Center

Chairs: Stephen J. Meltzer, John M. Carethers

11:15

F u n c t i o n a l e x p r e s s i o n a n d c h a r a c t e r i z a t i o n of CCK-B/muscarinic M3-chimeric receptors. (Abstract# G4730) DF Krametter, T Ohtaki, Y-J Guo, J Park, CJ Dickinson and J Del Valle. Ann Arbor, MI

11:30

E l u c i d a t i o n of r e c e p t o r d o m a i n s of g a s t r i n r e l e a s i n g p e p t i d e r e c e p t o r d e t e r m i n i n g high selectivity for p e p t i d e a n t a g o n i s t s . (Abstract# G4719) T Katsuno, TK Pradhan, SA Mantey, PJ Donohue, JF Battey, DH Coy and RT Jensen. New Orleans, LA and Bethesda, MD

11:45

C o n s t i t u t i v e a c t i v a t i o n of the h u m a n VIP1/PACAP receptor, a m e m b e r of the n e w class II family of G p r o t e i n - c o u p l e d receptors. (Abstract# G4682) P Gaudin, JJ Maoret, A Couvineau, C RouyerFessard and M Laburthe. Paris, France

H N P C C AND MICROSATELLITE INSTABILITY 10:30

10:45

11:00

11:15

11:30

11:45

D i a g n o s t i c v a l u e of Bethesda c r i t e r i a for HNPCC-screening. (Abstract# G2594) F Kullmann, A Beham, W Dietmaier, T Bocker, VD Mohr, K-W Jauch, J Sch61merich and J Riischoff. Regensburg, Germany Is BAT-26 a r e l i a b l e m a r k e r of microsatellite i n s t a b i l i t y i n s p o r a d i c colorectal t u m o r s ? (Abstract# G2600) P Lage, M Cravo, C Albuquerque, P Chaves, I Claro, T Gomes, C Gaspar, P Fidalgo and C Nobre-Leit~o. Lisbon, Portugal H e r e d i t a r y non-polyposis colorectal cancer: c a n c e r p a t t e r n s i n g e r m l i n e m u t a t i o n (hMSH2, hMLH1) positive a n d m u t a t i o n n e g a t i v e families. (Abstract# G2844) LKF Temple, B Bapat, L Madlensky, M Redston, T Hiruki, Z Cohen, RS McLeod and S Gallinger. Toronto, Canada Oxidative stress caused by H 2 0 2 d o w n r e g u l a t e s the level of hMSH2 p r o t e i n . (Abstract# G2358) CL Chang, HT Ha, L Olsen, G Marra, DP Chauhan, LA Laghi, JM Carethers and CR Boland. San Diego, CA A d e n o c a r c i n o m a i n v o l v i n g colonic h y p e r p l a s t i c polyps is associated with loss of DNA r e p a i r e n z y m e MLH-1. (Abstract# G2338) LJ Burgart, KP Batts, L Wang, PC Roche, DJ Tester and SN Thibodeau. Rochester, MN P r e s e n c e of m i c r o s a t e l l i t e i n s t a b i l i t y i n the n o r m a l - a p p e a r i n g e p i t h e l i u m of familial j u v e n i l e polyps. (Abstract# G2350) JM Carethers, BM Lopez, AF Zigman, W-S Jo, JE Lavine, MC Jones, DP Chauhan, CL Chang, HD Appleman and CR Boland. San Diego, CA and Ann Arbor, MI

Clinical Practice AGA Research Forum

10:30 am-12:00 p m

Room 37 Ernest N. Morial Convention Center

I N S T R U M E N T S USED IN OUTCOMES RESEARCH 10:30

10:45

E v a l u a t i o n of a p a t i e n t s y m p t o m m e a s u r e for c o n s t i p a t i o n . (Abstract# G0054) L Frank, C Farup, R Jones, P Miner, L Taylor and L Kleinman. Bethesda, MD; Oklahoma City, OK and Seattle, WA

11:00

The clinical u t i l i t y of t h e P a r k Nicollet Digestive Health S t a t u s I n s t r u m e n t for p a t i e n t s with g a s t r o e s o p h a g e a l reflux disease. (Abstract# G0165) MJ Shaw, TJ Beebe, SA Adlis, PA T0mshine and NJ Talley. Minneapolis, MN and Penrith, Australia

11:15

Q u a l i t y of life i n reflux a n d dyspepsia. Development and psychometric d o c u m e n t a t i o n of a disease-specific q u e s t i o n n a i r e (QOLRAD). (Abstract# G0199) I Wiklund, 0 Junghard, E Grace, NJ Talley, MA Kamm, SV van Zanten, P Par~, N Chiba, D Leddin, MA Bigard, R Colin and P Schoenfeld. Moelndal, Sweden; Mississauga, Halifax, Quebec and Guelph, Canada; Sydney, Australia; Harrow, United Kingdom; Nancy and Rouen, France; Bethesda, MD

11:30

R a p i d u r e a s e t e s t i n g i n r o u t i n e clinical practice: do practice g u i d e l i n e s m a k e a difference? (Abstract# G0189) N Vakil, P de Garmo and D Lieberman. Milwaukee, WI and Portland, OR

D E T E R M I N A T I O N OF DOMAINS CRITICAL FOR R E C E P T O R ACTIVATION M u t a t i o n a l a n a l y s i s suggests different molecular mechanisms of CCK-B/gastrin

receptor activation by endogenous peptides v e r s u s s y n t h e t i c drugs. (Abstract# G4623) M Bl~ker, Y Ren, L Sundararajan, EW McBride, M Beinborn and AS Kopin. Boston, MA 10:45

S e r i n e 260, 264, 271 a n d 275 i n the N - t e r m i n a l t h i r d i n t r a c e l l u l a r loop of the CCK-A r e c e p t o r a r e k e y a m i n o acids for the i n i t i a t i o n of signal t r a n s d u c t i o n . (Abstract# G4848) Y Tsunoda, I Song, LP Taylor and C Owyang. Ann Arbor, MI

P l a n n i n g a r a n d o m i z e d clinical t r i a l i n

dyspepsia: do we have a v a l i d outcome m e a s u r e ? (Abstract# G0144) L Rabeneck, KF Cook and NP Wray. Houston, TX

Chairs: Chung Owyang, John H. Walsh

10:30

Room 44 Ernest N. Morial Convention Center

Chairs: John F. Johanson, Dawn Provenzale

Hormones, Transmitters, Growth Factors and Their Receptors AGA Research Forum

10:30 am-12:00 p m

T w o d i s t i n c t m e c h a n i s m s d e t e r m i n e t h e ability

P202 P R O G R A M O F T H E A N N U A L M E E T I N G

Pancreatic Disorders

G A S T R O E N T E R O L O G Y Vol. 114~ No. 4

11:00

A novel " a n t i g e n " assay b a s e d o n stool s p e c i m e n for the d e t e c t i o n a n d t h e follow-up of Helicobaeterpylori. P r e l i m i n a r y r e p o r t . (Abstract# G1295) D Vaira, M Menegatti, C Acciardi, F Landi, C Ricci, B Massardi, F Mucci and M Miglioli. Bologna, Italy

11:15

Prospective e v a l u a t i o n of the effect of p r o t o n p u m p i n h i b i t o r t h e r a p y o n H. p~lori d i a g n o s t i c testing. (Abstract# G0792) L Laine, R Estrada, M Trujillo, C Knigge and MB Fennerty. Los Angeles, CA and Portland, OR H. pylori d e t e c t i o n b y i m m u n o m a g n e t i c s e p a r a t i o n i n clinical matrices. (Abstract# G0805) D Lau, S Yang, H Shmuely, K Turner and J Parsonnet. Alameda and Stanford, CA

AGA Research Forum

10:30 am-12:00 p m

Room 6 4 / 6 5 / 6 6 Ernest IV. Morial Convention Center

Chairs: Randall K. Pearson, Daniel S. Longnecker CLINICAL E X O C R I N E / E N D O C R I N E TUMORS OF THE PANCREAS 10:30

S e r u m islet a m y l o i d p o l y p e p t i d e i n p a n c r e a t i c c a n c e r (PC)-induced diabetes m e l l i t u s (DM): a s c r e e n i n g test to detect PC i n p a t i e n t s over 50 w i t h n e w o n s e t DM? (Abstract# G1813) S Chari, G Klee, LJ Miller, M Raimondo and EP DiMagno. Rochester, MN

10:45

High r e o l u t i o n s c a n of genome r e a r r a n g e m e n t s i n g a s t r i n o m a s . (Abstract# G2084) F Yu, Y-L Zheng, RT Jensen, IA Lubensky and LJ Ferrin. Bethesda, MD

11:00

D e t e c t i o n of t u m o r cells i n p e r i p h e r a l blood and bone marrow in patients with pancreatic cancer. (Abstract# G2089) K Z'graggen, BA Centeno, J Werner, AL Warshaw, RE Jimenez, S Kupa and C Fernandez-del Castillo. Boston, MA

11:15

11:30

11:45

O c c u r r e n c e of m u l t i p l e e n d o c r i n e n e o p l a s i a type I gene m u t a t i o n s i n p a t i e n t s with Zollinger-Ellison s y n d r o m e . (Abstract# G2022) J Serrano, SU Goebel, C Heppner, AL Burns, SJ Marx, F Gibril and RT Jensen. Bethesda, MD O v e r e x p r e s s i o n of cyclin D1 p r o t e i n i n p a n c r e a t i c e n d o c r i n e t u m o r s . (Abstract# G1821) DC Chung, SB Brown, F Graeme-Co0k, AL Washaw, M Seto, RT Jensen and A Arnold. Boston, MA; Farmington, CT; Nagoya, Japan and Bethesda, MD E v a l u a t i o n of t h e FDG-PET for the d i f f e r e n t i a t i o n of c h r o n i c p a n c r e a t i t i s a n d p a n c r e a t i c c a n c e r - a b e n e f i t for the surgeon? (Abstract# G19U) A Imdahl, E Nitzschel, F Krautmann, G Ruf and EH Farthmann. Freiburg, Germany

11:30

11:45

Gastrointestinal Oncology AGA Research Forum

10:30 am-12:00 p m

INVASION AND METASTASES 10:30

P e r i t o n e a l lavage p e r f o r m e d d u r i n g laparoscopic s t a g i n g of GI m a l i g n a n c i e s : is it useful? (Abstract# G2697) EJM Nieveen van Dijkum, P Sturm, LT de Wit, F Ten Kate, H Obertop and DJ Gouma. Amsterdam, The Netherlands

10:45

Micrometastases i n foregut cancer: h i g h detection r a t e i n r i b m a r r o w c o m p a r e d w i t h iliac crest. (Abstract# G2722) GC O'Sullivan, A Clarke, R Stuart, J Kelly, MD Kiely, JK Collins and F Shanahan. Cork, Ireland and Glasgow, Scotland I d e n t i f i c a t i o n of col0rectal c a n c e r m i c r o m e t a s t a s e s u s i n g n e s t e d RT-PCR analysis of MUC2 m u c i n i n l y m p h nodes. (Abstract# G2472) HJ Gonzalez, A Bernini, S Frizelle, R Anway, RD Madoff, GA Niehans, RA Kratzke and SB Ho. Minneapolis, MN C o n t r i b u t i o n of m a t r i x m e t a l l o p r o t e i n a s e s to colorectal c a n c e r i n v a s i o n a n d metastasis. (Abstract# G2590) FJGM Kuhben, W van Duijn, MAC Mieremet-O0ms, AML Janssen, V S~iwer,A Oberpichler, H Tschesche, JH Verheijen, R Hanemaaijer, G Griffioen, CBHW Lamers and HW Verspaget. Leiden, The Netherlands and Bielefeld, Germany Modifying e x p r e s s i o n of the ~-galactoside b i n d i n g p r o t e i n galectin-3 s i g n i f i c a n t l y alters the m e t a s t a t i c a b i l i t y of h u m a n colon c a n c e r cells. (Abstract# G2331) RS Bresalier, N Mazurek, L Sternberg, C Yunker, JC Byrd, S Daniel, P Nangia-Makker and A Raz. Detroit, MI Fas l i g a n d e x p r e s s i o n d e t e r m i n e s liver c o l o n i z a t i o n competence of colonic a d e n o c a r c i n o m a , (Abstract# G2865) N Tsuji, A Tsuji, K Shiraki and H Takahashi. Boston, MA

11:00

E s o p h a g e a l , Gastric, a n d D u o d e n a l D i s o r d e r s Room 85/86 Ernest N. Morial Convention Center

11:15

Chairs: David C. Metz, William Y. Chey HELICOBACTER PYLORI: DIAGNOSTIC T E S T I N G 10:30

10:45

R a p i d whole blood a n t i b o d y tests for the diagnosis of Helicobacter pylorl infection: c o m p a r i s o n w i t h histology, r a p i d urease, u r e a b r e a t h a n d s e r u m - b a s e d testing. (Abstract# G0482) DO Faigel, N Magaret, DA Lieberman and MB Fennerty. Portland, OR

11:30

V a l i d a t i o n of t h e 13C-urea blood test for H.

pylori infection: a US, m u l t i c e n t e r trial. (Abstract# G0371) WD Chey, U Murthy, PP Toskes, S Carpenter and L Laine. Ann Arbor, MI; Syracuse, NY; Gainsville, FL; Savannah, GA and Los Angeles, CA

Room 89 Ernest IV. Morial Convention Center

Chairs: Robert S. Bresalier, Samuel B. Ho

AGA Research Forum

10:30 am-12:00 p m

Detection of Helieobacterpylorlin c o n t a m i n a t e d samples u s i n g p o ! y m e r a s e c h a i n r e a c t i o n b a s e d o n the i s o c i t r a t e d e h y d r o g e n a s e gene. (Abstract# G0634) LL Huang, P Grtibel, N Masubuchi, PJ Goddard, JS Hoffman and DR Cave. Boston, MA

11:45

April1998

P R O G R A M O F THE ANNUAL M E E T I N G P203

WEDNESDAY, MAY 20, 1998 Esophageal, Gastric, and Duodenal Disorders AGA Research Forum

Intestinal Disorders AGA Research Forum

10:30 am-12:00 p m

10:30 am-12:00 p m

Room 9 0 / 9 1 / 9 2 Ernest N. Morial Convention Center

Room 99 Ernest N. Morial Convention Center

Chairs: Joel E. Richter, Stuart J. Spechler

Chairs: Deborah C. Rubin, Gary D. Wu

ANTIREFLUX SURGERY

I N T E S T I N A L ADAPTATION AND APOPTOSIS

10:30

10:30

I m b a l a n c e of BCL-2 family p r o t e i n expression b y m u c o s a l T cells favors r e s i s t a n c e to apoptosis i n C r o h n ' s disease. (Abstract# G1552) J Itoh, AD Levine and C Fiocchi. Cleveland, OH

10:45

Extracellular matrix protein promotes s u r v i v a l of h u m a n colonic sub-epithelial myofibroblasts b y ~ l - i n t e g r i n d e p e n d e n t i n h i b i t i o n of apoptosis. (Abstract# G1561) TM Jobson, BC McKaig, J Savfll, YR Mahida and IP Hall. Nottingham, United Kingdom

11:00

B u t y r a t e i n d u c e s apoptosis a n d t h e expression of WAF-1, GADD, TGF-~ a n d IGFBP-2 i n IEC-6 cells. (Abstract# G1533) Y-S Guo, JC Thompson, MR Hellmich and CM Townsend, Jr. Galveston, TX

11:15

Hepatocyte g r o w t h factor protects gastric e p i t h e l i a l cells a g a i n s t c e r a m i d e - i n d u c e d apoptosis t h r o u g h i n d u c t i o n of cyclooxygenase-2. (Abstract# G1697) T Shimada, K Sakata, N Watanabe, M Endoh, Y Ohtsuka, H Hiraishi and A Terano. Tochigi, Japan

11:30

Oligopeptide t r a n s p o r t e r PEPT1 mRNA e x p r e s s i o n i n h u m a n i n t e s t i n a l mucosa: gut g r a d i e n t , c e l l u l a r l o c a l i z a t i o n a n d colonic u p r e g u l a t i o n i n s h o r t bowel s y n d r o m e . (Abstract# G1776) TR Ziegler, CF Estivariz, LH Gu, TM Wallace, EE Diaz, RR Pascal, JR Galloway, JN Wilcox and LM Leader. Atlanta, GA

11:45

A role for the g u t - e n r i c h e d Kriippel factor i n i n t e s t i n a l a l k a l i n e p h o s p h a t a s e gene t r a n s a c t i v a t i o n . (Abstract# G1580) J Kim, A Shei, S Meng, V Yang and RA Hodin. Boston, MA and Baltimore, MD

10:45

11:00

Omeprazole or a n t i r e f l u x s u r g e r y i n the long t e r m m a n a g e m e n t of gastroesophageal reflux disease. R e s u l t s of a m u l t i c e n t r e , r a n d o m i s e d clinical trial. (Abstract# G0848) L Lundell, J Dalenb~ck, J Hattlebakk, E Janatuinen, K Lewander, P Miettinen, HE Myrvold, SA Pedersen, K Thor, A Andersson, P NystrSm, I Wiklund and the Nordic GERD Study Group. Huddinge, Sweden; Kuopio, Finland; Trondheim, Norway and Odense, Denmark The cost of o m e p r a z o l e versus open anti-reflux s u r g e r y i n t h e l o n g t e r m m a n a g e m e n t of reflux esophagitis. (Abstract# G0973) HE Myrvold, L Lundell, B Liedman, J Hatlebakk, P Miettinen, E Janatuinen, SA Pedersen, K Thor, K Lewander, P HystrSm, NO St~lhammar and the Nordic GERD Study Group. Tr0dheim and Bergen, Norway; GSteborg, MSlndal and Stockholm, Sweden; Kuopio, Finland; Odense, Denmark P o s t - f u n d o p l i c a t i o n dysphagia: a b n o r m a l r a m p (intra-bolus) p r e s s u r e provides s u b s t a n t i a t i o n of a '~ight wrap". (Abstract# G1207) D Staff, K Saeian, BT Massey, R Shaker and WJ Hogan. Milwaukee, WI

11:15

Successful v e r s u s 'qess successful" f u n d o p l i c a t i o n s : Too loose? Too tight? T o o l o w ? (Abstract# G0471) GA Ergun, S Lin, RJ Joehl and PJ Kahrflas. Chicago, IL

11:30

Impaired gastroesophageal junction transit w i t h f u n d o p l i c a t i o n . (Abstract# G1203) AE Spiess, S Lin, RJ Joehl and PJ Kahrilas. Chicago, IL

11:45

A n t i r e f l u x s u r g e r y i n Sweden d u r i n g 19871996: a decade of change. (Abstract# Gl129) R Sandbu, D Arvidsson, S Gustavsson and T Hallgren. Uppsala, Sweden

P204 PROGRAM OF THE ANNUAL MEETING

GASTROENTEROLOGYVol. 114~No. 4

WEDNESDAY, MAY 20, 1998 MEET-THE-PROFESSOR/MEET-THE-INVESTIGATORL U N C H E O N S 12:30 P M t o 1:45 P M

MEET-THE-INVESTIGATOR L U N C H E O N S 90 91 92

Helen J. Cooke C. Richard Boland Karen E. Hall

93 94

Satish C. Rattan David S. Weinberg

Enteric reflexes and secetion Research update: molecular biology of cancer Investigating intracellular signal transduction: lessons from diabetic neuropathy Internal anal sphincter regulation Molecular epidemiology of GI cancers MEET-THE-PROFESSOR

95 96 97

Sami R. Achem Jamie S. Barkin Randall W. Burt

98 99 100 101 102 103 104 105 106 107 108

David L. Cart-Locke James L. Achord Oliver W. Cass John Baillie Ray E. Clouse John T. Cunningham John DelValle Tom R. DeMeester Douglas A. Drossman Grace H. Elta Rosemarie L. Fisher David E. Fleischer James H. Grendell

109 110 111 112

David A. Johnson Kenneth L. Koch Loren A, Laine John R. Lake

113 114 115 116 117 118 119 120

David A. Lieberman Richard R. Locke Willis C. Maddrey Paul Martin Roy C. Orlando Philip O. Katz Carlos A. Pellegrini Jeffrey L. Ponsky Jeffrey Raskin

121

Howard A. Reber

122 123

Marvin M. Schuster Jacques Van Dam Gregory Zuccaro 123A Kenneth K. Wang 124 Wilfred M. Weinstein

Harland Winter Helen Shields

127

Brad Jones Sumner Bell

Crescent Edgewood

Sheraton Sheraton Convention Center

Bonnie Burn EUendale Room 20

LUNCHEONS

Noncardiac chest pain Acute pancreatitis Clinical application of new genetic findings in colon cancer Therapeutic pancreatic and biliary endoscopy Training issues in endoscopy

Convention Center Convention Center

Room 22 Room 24

Convention Center Convention Center Sheraton

Room 5 Room 23 Bayside B

Diagnosis and management of esophagus disorder ERCP in the era oflaparoscopy Gastrointestinal hormones in health and disease Anti-reflux surgery IBS and chronic abdominal pain Sphincter of Oddi dysfunction Difficult cases in nutrition support Endoscopic therapy for GI neoplasm New developments in acute pancreatitis: approach to pancreatic cancer Extraesophageal complications of GERD Unexplained nausea and vomiting Upper GI bleeding Post-transplant management of liver transplant recipients Community-based outcomes research Outcomes research in gastroenterology Management of chronic hepatitis C Selection for liver transplantation Pathogenesis and treatment of reflux esophagitis Surgical therapy of GERD: medical versus surgery for GERD Percutaneous endoscopic gastrostomy Endoscopic complications: prevention and management Surgery for pancreatic cancer: what the gastroenterologist should know Irritable bowel syndrome Hospital privileges for endoscopy. Obtaining them, maintaining them, protecting them Telemedicine GI biopsy issues for endoscopists

Convention Center Convention Center Convention Center Convention Center Convention Center Convention Center Sheraton Convention Center

Room 27 Room 29 Room 31 Room 26 Room 28 Room 36 Room 829 Room 38

Convention Center Convention Center Convention Center Convention Center

Room 39 Room 40 Room 41 Room 42

Convention Center Convention Center Sheraton Sheraton Sheraton Sheraton

Room 43 Room 21 Evergreen Felicity Gallier House Oakley

Sheraton Sheraton

Rosella Southdown

Sheraton

BaysideA

Sheraton Sheraton

Suite 816 Suite 817

Sheraton Sheraton Sheraton

St. charles A St. Charles B Suite 821

AGA PROBLEM-BASED

125 126

Sheraton Sheraton

LEARNING SESSIONS

Pancreas divisum in a 16 year old Low grade dysplasia in longstanding ulcerative colitis Negotiating managed care contracts

Sheraton

Suite 824

Sheraton Sheraton

Suite 825 Esterwood

PROGRAMOFTHEANNUALMEETINGP205

April 1998

AGA

POSTER

SESSION

-- WEDNESDAY,

Poster Session

8:00 am-5:00 p m

Hall D Ernest N. Morial Convention Center

Authors are required to present during the Poster Session from 12:00-2:30 pm

Those posters identified as DDW Posters of Distinction have received review scores that place them within the top 10% of all posters. We encourage you to make them a priority as you visit the poster session. CLINICAL PRACTICE - - III

D D W Poster of Distinction: P r e d i c t o r s of p a t i e n t p r e f e r e n c e a n d acceptance of colon c a n c e r s c r e e n i n g g u i d e l i n e s i n the average risk p o p u l a t i o n . (Abstract# G0053) NM Fox and DE McGuire. Ft Lauderdale, FL

D D W Poster of Distinction: Does o p e n access to colonoscopy affect its diagnostic yield? (Abstract# G0090) WR Kim, GR Locke, RW Evans, AR Zinsmeister and CJ Gostout. Rochester, MN

D D W Poster of Distinction: Role of sigmoidoscopy a n d fecal occult blood t e s t i n g i n s c r e e n i n g for colorectal cancer. (Abstract# G0071) JF Helm, KN Simpson and RS Sandler. Chapel Hill, NC Are c r i t e r i a to e v a l u a t e the a p p r o p r i a t e n e s s of p e r f o r m i n g a colonoscopy evidence-based? (Abstract# G0023) B Burnand, A Fahrni, F Fr0ehlich, JP Vader and JJ Gonvers. Lausanne, Switzerland Time r e q u i r e d for t r a i n i n g i n endoscopy. A prospective s t u d y of 362 c o n s e c u t i v e colonoscopies. (Abstract# G0041) F Devulder, P Gallet and P Zeitoun. Reims, France P r o s p e c t i v e c o m p a r i s o n of a i r - c o n t r a s t b a r i u m e n e m a a n d colonoscopy i n p a t i e n t s w i t h fecal occult blood. (Abstract# G0146) DC R0ckey, R Halv0rsen and K McQuaid. San Francisco, CA and Durham, NC S o d i u m p h o s p h a t e a n d cisapride for precolonoscopy bowel c l e a n s i n g : a prospective, r a n d o m i z e d study. (Abstract# G0U3) J Martinek, J Hess, R Mally, P J0rn0d, P Wiesel, P Pescatore, J Delarive, AL Blum and G Dorta. Lausanne, Switzerland What clinical p a r a m e t e r s p r e d i c t t h a t a p a t i e n t c a n u n d e r g o a gastroscopy comfortably w i t h o u t the n e e d for conscious s e d a t i o n ? (Abstract# G0009) AN Barkun, CA Fallone, S Mayrand and G Friedman. Montreal, Canada Outcomes of conscious s e d a t i o n i n c h i l d r e n u n d e r g o i n g GI endoscopy: a prospective o b s e r v a t i o n a l study. (Abstract# G0032) IZ Dahodwala, KB Freeman, NS Miller, JZ Coutu, E Jelalian, F A1-Qawasmi and JW Adelson. Providence, RI How safe is endoscopic d i l a t a t i o n i n b e n i g n a n d m a l i g n a n t esophageal s t r i c t u r e s ? (Abstract# G0074) RS H0dgs0n and TK Daneshmend. Exeter, United Kingdom

MAY

20, 1998

Does this p a t i e n t h a v e B a r r e t t ' s esophagus (BE)? The a b i l i t y to p r e d i c t BE at i n d e x endoscopy. (Abstract# G0043) M Eloubeidi and D Provenzale. Durham, NC Are self-expanding m e t a l s t e n t s (Ultraflex ® a n effective t r e a t m e n t for m a l i g n a n t esophageal o b s t r u c t i o n ? A prospective study. (Abstract# G0147) A Rolachon, E Papillon and J Fournet. Grenoble, France Endoscopic i n s e r t i o n of g a s t r o s t o m y tubes, b u t t o n s or laparoscopic ports: a n e w method. (Abstract# G0072) CC Hepw0rth, EA Stoner, AE Stuart and CP Swain. London and Romford, United Kingdom Assessment of p e r c u t a n e o u s endoscopic gastrostomy i n the elderly. (Abstract# G0001) V Abitbol, M Gaudric, Y Gallais, JP Bouchon, JB Piera, M Laurent, F Piette and R Moulias. Paris and Ivry/Seine, France R a d i a t i o n exposure of ERCP s t a f f - m e a s u r e m e n t of o r g a n doses. (Abstract# G0002) H Ab0u-Rebyeh, N Hidayat, R Sabha, A Adler, W Veltzke, T Vogl and RE Hintze. Berlin, Germany P r o p h y l a c t i c a d m i n i s t r a t i o n of a n t i b i o t i c s before i n t e r v e n t i o n a l ERCP i n p a t i e n t s w i t h o u t p r e e x i s t i n g infection. (Abstract# G0122) M Mrol], S Kiipferling, M Ortner, H Briedigkeit, U Goebel and H Lochs. Berlin, Germany Propofol versus m i d a z o l a m for conscious s e d a t i o n d u r i n g ERCP - a r a n d o m i z e d p r o s p e c t i v e study. (Abstract# G0084) M Jung, C Hofmann and A Brackertz. Mainz, Germany Diagnosis of s u b m u c o s a l t u m o r of the s t o m a c h by endoscopic u l t r a s o n o g r a p h y . (Abstract# G0188) E Umegaki, M Tanaka, K Nishimura, H Takiuchi, T Matsumoto, K Maemura, Y Kurisu, S Tokioka, S Asada, I Hirata and K Katsu. Osaka, Japan Diagnosis of s u b m u c o s a l t u m o r s of t h e u p p e r g a s t r o i n t e s t i n a l t r a c t b y e n d o s o n o g r a p h y assessed endoscopic resection. (Abstract# G0092) T Kojima, H Takahashi, A Parra-Blanco, S Ohguri and R Fujita. Yokohama, Japan Role a n d place of endoscopic u l t r a s o n o g r a p h y i n the m a n a g e m e n t of p a n c r e a t i c a n d a m p u l l a r y carcinoma. (Abstract# G0024) L Buscail, P Pages, G Fourtanier, J Frexinos and J Escourrou. Toulouse, France Does EUS help the s u r g e o n i n s t a g i n g p a n c r e a t i c a n d a m p u l l a r y cancers? (Abstract# G0105) T Lok Tio, W Mayoral, J Salcedo, PK Roy, J Sitzmann, F A1 Kawas, R Henderson, M Smith, XF Cusso and D Bandres. Washington, DC EUS a n d CUS i n p e r i a m p u l l a r y masses: s u r g e r y or nons u r g e r y ? (Abstract# G0106) T Lok Tio, JA Salcedo, XF Cusso, D Bandres, PK Roy, W Mayoral and F A1-Kawas. Washington, DC Systematic h e p a t i t i s C v i r u s s c r e e n i n g i n p a t i e n t s w i t h p r e v i o u s digestive endoscopy. (Abstract# G0061) JL Gaudin, A Hot, O Dumont, R Bobichon and JC Souquet. Lyon, France M i n i p r o b e s o n o g r a p h y c o m p a r e d to c o n v e n t i o n a l endoscopic u l t r a s o u n d i n p r e o p e r a t i v e s t a g i n g of esophageal carcinoma. (Abstract# G0117) J Menzel, H Nottberg, N H0epffner, N Senninger and W Domschke. Muenster, Germany

P206 P R O G ~ OF THE ANNUALMEETING II

AGA

POSTEI~

GASTROENTEROLOGYVol. 114~No. 4 SESSION

P r o s p e c t i v e r a n d o m i s e d s t u d y of t h e u s e of e a r l y l a p a r o s c o p y i n t h e m a n a g e m e n t of a c u t e non-specific a b d o m i n a l p a i n . (Abstract# G0035) B Decadt, L Sussman, M Lewis, L Cohen, A Patel, C Rogers and M Rhodes. Norwich, United Kingdom

-- WEDNESDAY,

MAY

20, 1 998

An office-based w h o l e b l o o d t e s t is p r e f e r a b l e to a laboratory quantitative serology test in the d e t e r m i n a t i o n of Helicobaeter pylori i n f e c t i o n d o c u m e n t e d b y e n d o s c o p i c biopsy. (Abstract# G0737) K Knigge, MG Fennerty, D Faigel, N Magaret, SP Marquis, G Vartan and L Laine. Portland, OR and Los Angeles, CA

S t a g i n g of p a n c r e a t i c a n d h e p a t o b i l i a r y m a l i g n a n c i e s by laparoscopy and laparoscopic ultrasound. (Abstract# G0036) B Decadt, L Cohen, L Sussman, A Patel, M Watson, M Lewis and M Rhodes. Norwich, United Kingdom

E v a l u a t i o n of t w o n e w c a p i l l a r y w h o l e b l o o d serologic t e s t s for d e t e c t i n g Hellcobacterpylori i n a s y m p t o m a t i c p o p u l a t i o n . (Abstract# Gl119) DC Sad0wski, RA Singh and R Shute. Edmonton, Canada

A r a n d o m i z e d c o n t r o l l e d t r i a l of r u b b e r b a n d l i g a t i o n v e r s u s i n f r a r e d c o a g u l a t i o n i n t h e t r e a t m e n t of h e m o r r h o i d s . (Abstract# G0139) AC Poen, RJF Felt-Bersma, W Knol, MA Cuesta and SGM Meuwissen. Amsterdam, The Netherlands

The serological d e t e c t i o n of H. p~vlori i n m e c h a n i c a l l y v e n t i l a t e d i n t e n s i v e c a r e p a t i e n t s . (Abstract# G1306) PHJ van der Vo0rt, RWM van der Hulst, DF Zandstra, AAM Geraedts and GNJ Tytgat. Amsterdam, The Netherlands

Benefits of l a p a r o s c o p i c s t o m a c r e a t i o n : a c a s e - m a t c h e d series. (Abstract# G0145) E Radice, T Young-Fadok and H Nelson. Rochester, MN

DDW Poster of Distinction: Does Helicobacter pylori s e r o l o g y p r e d i c t t h e i n t r a g a s t r i c b a c t e r i a l d e n s i t y of H. pylorl a n d t h e

P s y c h o l o g i c a l s t a t u s a n d q u a l i t y of life a f t e r l a p a r o s c o p i c s u r g e r y : a c o m p a r i s o n of o p e n v e r s u s l a p a r o s c o p i c c h o l e c y s t e c t o m y . (Abstract# G0029) G Costamagna, D Borz0mati, A Carcione, A Tringali, G Nicolb, M Marciano and F Crucitti. Rome, Italy

h i s t o l o g i c a l s e v e r i t y of g a s t r i t i s ? (Abstract# G1371) HH-X Xia, J Kalantar, JM Wyatt, S Adams, K Cheung, HM Mitchell and NJ Talley. Sydney, Australia

O p t i m a l d u r a t i o n of u r i n a r y d r a i n a g e a f t e r r e c t a l r e s e c t i o n : a r a n d o m i z e d c o n t r o l l e d t r i a l i n 126 p a t i e n t s . (Abstract# G0012) S Benoist, Y Panis, C Denet, F Mauvais, P Mariani and P Valleur. Paris, France I n t e s t i n a l a n a s t o m o t i c fistula: p r e d i c t i v e factors of m o r t a l i t y i n 59 c o n s e c u t i v e p a t i e n t s . (Abstract# G0006) A/Eves, Y Panis, P Mariani, C Denet and P VaUeur. Paris, France O u t p a t i e n t a n o r e c t a l s u r g e r y . The e x p e r i e n c e of a d e d i c a t e d c o l o r e c t a l s u r g i c a l unit. (Abstract# G0047) A Ferrara, SW Larach, PR Williams0n, MF Trevisani, P Loprete, J Cebrian and M Arroyo. Orlando, FL L o n g t e r m follow-up a f t e r l a p a r o s c o p i c colectomy.

(Abstract# G0203) T Young-Fad0k, H M0reira, Jr, H Nelson, S Wexner, M HeUinger, P Leggett, J Hyder and S Stryker. Rochester, MN; F t Lauderdale and Miami, FL; Houston, TX; Wichita, KS and Chicago, IL R a n d o m i s e d c o n t r o l l e d t r i a l of m e t r o n i d a z o l e to r e d u c e p a i n a f t e r d a y c a s e h e m o r r h o i d e c t o m y . (Abstract# G0027) EA Carapeti, MA Kamm, PJ McDonald and RKS Phillips. Harrow, United Kingdom Laparoscopic fundoplication in patients with Barrett's esop.hagus. (Abstract# S0184) S Oberg, JH Peters, TR DeMeester, MP Ritter, PA Crookes, SR DeMeester, JA Hagen and CG Bremner. Los Angeles, CA E S O P H A G E A L , GASTRIC, AND D U O D E N A L D I S O R D E R S - - HELICOBACTER PYLORI: DIAGNOSIS P e r f o r m a n c e of c o m m e r c i a l l y a v a i l a b l e serological ELISA t e s t for H. pyloriinfection: d i s c r e p a n c y b e t w e e n E a s t a n d West. (Abstract# G0827) WK Leung, EKW Ng and JY Sung. Hong Kong, China

DDW Poster of Distinction: F a i l u r e of Helicobactcrpylori s e r o l o g y t o i d e n t i f y m o s t peptic ulcer disease in patients with dyspepsia. (Abstract# G1372) HH-X Xia, J Kalantar, JM Wyatt, S Adams, K Cheung, HM Mitchell and NJ Talley. Sydney, Australia E v a l u a t i o n of a d r i e d p l a s m a c o l l e c t i o n d e v i c e for t h e d e t e c t i o n of H. pylori a n t i b o d i e s . (Abstract# G0368) EH Cheng, K Ashraf, M Roeske, F Rubenbauer, R Shaw, P Marchildon and J Peacock. Stony Brook, NY S h o r t half-life of s e r u m anti-CagA a n t i b o d y : c o m p a r i s o n w i t h c o n v e n t i o n a l anti.Helicobacterpylori a n t i b o d y . (Abstract# G1396) H Yoshida, S Maeda, K Ogura, R Kawaguchi, T Ikenoue, F Kanai, T Kawabe, Y Shiratori and M Omata. Tokyo, Japan A c o m p a r i s o n of 2 c o m m e r c i a l l y a v a i l a b l e f i n g e r s t i c k , w h o l e b l o o d a n t i b o d y t e s t s for H. pyloriinfection. (Abstract# G0369) WD Chey, W Linscheer, J Barnett, G Elta, L Fisher, T Nostrant, J Scheiman, A Zawadski, A Fayyad and U Murthy. Ann Arbor, MI and Syracuse, NY U t i l i t y of a r a p i d w h o l e blood t e s t for a n i n i t i a l d i a g n o s i s of Hclicobacterpyloriinfection. (Abstract# G0671) I K/i~ri/iinen, E Pulkkinen, K Romanoff, P Sipponen and L Sellin. Espoo and Masala, Finland E v a l u a t i o n of s e r o l o g i c a l a s s a y s for H. pylori cagA a n d vacA a n t i b o d i e s in p e d i a t r i c p a t i e n t s w i t h a b d o m i n a l pain. (Abstract# G0376) SKF Chong, TV Nowak, JA Nowak, S Mohindra, N Iglitzen and JH Kalbfleisch. Indianapolis, IN, Chicago, IL and Johnson City, TN 54 k D a p r o t e i n , b u t n o t 116 k D a p r o t e i n , m a y be c o n s i d e r e d a s e r o l o g i c a l m a r k e r o f Helfcobacterpylorfp o s i t i v e g a s t r i c c a r c i n o m a . (Abstract# G0638) G Iaquint0, N Giardullo, L Pasquale, V D'On0fri0, C Panico, A Andriulli, F Perri, C Rega, A Todisco, G De Chiara and W Taccone. Avellino and Foggia, Italy

April 1998

PROGRAMOF THEANNUALMEETINGP207

AGA POSTER SESSION m WEDNESDAY, The d i v e r s i t y of t h e t h i r t y - b a s e r e g i o n of vacA middle r e g i o n was i d e n t i f i e d a m o n g almost s t r a i n s isolated i n J a p a n . (Abstract# GU79) D Shirasaka, N Aoyama, K Satonaka, S Shigeta, H Yoshida, K Shirakawa, T Iida, T Sakai, Y Shinoda, T Ikemura, M Sakashita, M Miyamoto and M Kasuga. Kobe, Japan

M A Y 20, 1 9 9 8

Use of a d r y p l a s m a collection c a r d for simplified diagnosis of Helicobaeterpylori infection. (Abstract# G0706) DJ Kearney, M Chflds, L Boes and J Peacock. Seattle, WA and Stony Brook, NY

DDW Poster of Distinction: DDW Poster of Distinction: H. pylori g e n o t y p e s a n d p h e n o t y p e s i n isolates of the h u m a n g a s t r i c mucosa. (Abstract# G0535) M Gerhard, N Neumayer, W Schepp, M Classen, N Lehn and C Prinz. Munich and Regensburg, Germany

A novel m e t h o d a n d device for Helicobaeterpylori detection: c o n t i n u o u s , fast 13C-urea b r e a t h test. (Abstract# G0642) Y Ilan, YY Israelit, S Bar Meir, S Yudchack and E Goldin. Jerusalem, Israel

DDW Poster of Distinction:

DDW Poster of Distinction:

Single-stranded conformational polymorphiasm a n a l y s i s is a p o w e r f u l m e t h o d for d i s c r i m i n a t i n g Helieobaeterpylori isolates. (Abstract# G0659) C Jiang, C Li, DA Ferguson, Jr, DS Chi, T Ha, JJ Laffan and E Thomas. Johnson City, TN

Urea hydrolysis r a t e c a l c u l a t i o n n o r m a l i z e s the 13Cu r e a b r e a t h test for age, sex, height, a n d weight. (Abstract# G0731) PD Klein, HM Malaty, DY Graham, S Czinn, SEmmons and R Martin. Houston, TX; Cleveland, OH; Nashville, TN and Concord, MA

Direct d i s c r i m i n a t i o n of Helivobacterpyloristrains from g a s t r i c biopsies b y s i n g l e - s t r a n d e d c o n f o r m a t i o n a l p o l y m o r p h i s m analysis. (Abstract# G0658) C Jiang, C Li, DA Ferguson, Jr, DS Chi, T Ha, JJ Laffan and E Thomas. Johnson City, TN D e t e c t i o n of H. pyloriinfections b y u r i n e - b a s e d e n z y m e - l i n k e d i m m u n o s o r b e n t assay. (Abstract# G0693) M Kate, T Kobayashi, J Ishizuka, T Kudo, M Katagiri, Y Komatsu, F Sato, M Sukegawa, H Kagaya, K Nishikawa, Y Ooae, K Hokari, H Takada, T Sugiyama and M Asaka. Sapporo, Japan V a l i d a t i o n of t h e PCR s t r i n g test (entero-test) i n the diagnosis of Helleobaeterpylori gastritis. (Abstract# G0853) S Lynch, TV Nowak, JA Nowak, F Konicek, K Ghazanfari and A 01ivera. Indianapolis, IN and Chicago, IL A novel r e a l - t i m e q u a n t i t a t i v e PCR assay for detection of Helleobaeterpylori i n the gastric mucosa. (Abstract# G0468) M Endoh, T Shimada, N Watanabe, Y Ohtsuka, K Sakata, T Sasai, H Hiralshi and A Terano. Tochigi, Japan T r a n s p o r t of gastric m u c u s o n d r y cotton swabs does n o t affect P C R d e t e c t i o n of H. pylori. (Abstract# G1357) HM Windsor, GY Ho, BH Laurence, DJE Cullen, GC MacQuillan and BJ Marshall. Perth, Australia Histologic d i a g n o s i s of H. pyloriin dyspeptic p a t i e n t s : a c o m p a r i s o n a m o n g pathologists. (Abstract# G0358) C Charles, M Sue, H Reid, D Hooper, E Morris and D Peura. Turkeyen, Guyana and Charlottesville, VA A u t o f l u o r e s c e n c e i n Helleobaeterpylori infectioni n d u c e d gastritis. (Abstract# G0898) H Matsui, Y Murata, K Hirano, A Yanaka, A Nakahara, H Muto, F Kobayashi and K Momo. Tsukuba and Nogi, Japan The p r e s e n c e of a t r o p h y a n d i n t e s t i n a l m e t a p l a s i a does n o t r e l a t e to a d e c r e a s e d Helicobaeterpylori detection from a n t r u m . (Abstract# G1315) BWlVlvan 't Hoff, RWM van der Hulst, A van der Ende, MHMG Houben, J Dankert, FJW ten Kate, EAJ Rauws and GNJ Tytgat. Amsterdam, The Netherlands Gastric j u i c e a m m o n i a a s s a y for diagnosis of Helivobacterpylorlinfection. (Abstract# G0705) DJ Kearney, M Chflds, L Boes and J Peacock. Seattle, WA and Stony Brook, NY

DDW Poster of Distinction: C o m p a r i s o n of 13C-urea blood test to 13C-urea b r e a t h test for diagnosis of H. pylor£ (Abstract# G0394) AF Cutler and S Miller. Detroit, MI C o m p a r i s o n of 13C-urea b r e a t h a n d blood tests for H.

pylori. (Abstract# G0949) KE M6nkemiiller, G Hortin, T Li and BI Hirschowitz. Birmingham, AL Cut-off a n a l y s i s of 13C-urea b r e a t h test r e s u l t s i n adults a n d children. (Abstract# G0227) S Amarri, F Franc'hini, A Ranzi, G Banchini, C Zanacca, S Bulgarelli and F Balli. Modena and Reggio Emilia, Italy The 13C-urea b r e a t h test: a n excellent n o n - i n v a s i v e m e t h o d for d e t e c t i o n of H. pylori i n f e c t i o n i n p e d i a t r i c patients. (Abstract# G0840) KN Liquornik, CA Liacouras, ED Richelli and DC Metz. Philadelphia, PA Gastritis i n p e d i a t r i c p a t i e n t s : c o r r e l a t i o n of gross endoscopic f i n d i n g s with histological results. (Abstract# G0839) KN Liquornik, CA Liacouras, ED Ruchelli and DC Metz. Philadelphia, PA A c o m p a r a t i v e t r i a l to optimize t h e protocol of t h e 13Cu r e a b r e a t h test for the d i a g n o s i s of Helieobaeterpylori infection. (Abstract# G1403) RM Zagari, P Pozzato, F Bazzoli, S Fossi, L Ricciardiello, G Nicolini, D Berretti, L de Luca, G Alampi, N Salfi, G Martinelli, S Sottili, D Festi, M Neri, P Simoni, A Roda and E Roda. Bologna and Chieti, Italy Effect of different test meals o n t h e LARA system 13Cu r e a b r e a t h test i n H. pylo~-infected volunteers. (Abstract# G1354) MP Williams, JC Sercombe and RE Pounder. London, United Kingdom How does citric acid i n c r e a s e u r e a s e activity in vivo? (Abstract# G0565) DY Graham, D Runke-Garcia, SY Anderson, HM Malaty and PD Klein. Houston, TX P o s t - e r a d i c a t i o n e v a l u a t i o n of H. pylori status: the 13Cu r e a laser assisted r a t i o a n a l y z e r b r e a t h test. (Abstract# G0626) MHMG Houben, EF Hensen, P Stam, BWM van 't Hoff, RWM van der Hulst, A van der Ende, FJW ten Kate and GNJ Tytgat. Amsterdam, The Netherlands

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A G A P O S T E R S E S S I O N w W E D N E S D A Y , M A Y 20, 1998 Q u a n t i f i c a t i o n of ttellcobaeterpylorl i n f e c t i o n i n g a s t r o d u o d e n a l diseases u s i n g t h e endoscopic 13C-urea b r e a t h test. (Abstract# G1219) H Suto, T Azuma, S Ito, Y Ito, H Miyaji, Y Yamazaki, M Kuriyama and Y Kohli. Fukui and Kyoto, Japan The [14-C]urea b r e a t h test is n o t sensitive for detection of a c u t e e x p e r i m e n t a l Helicobacterpylori i n f e c t i o n i n the r h e s u s m o n k e y model. (Abstract# Gl191) JV Solnick and DR Canfield. Davis, CA A d v a n t a g e s of n e a r p a t i e n t t e s t i n g f o r / / , pylori u s i n g i n f r a r e d isotope analysis. (Abstract# G0578) P Gummett, MM Walker, V Loh, HJW Thomas, JP Teare and MR Thursz. London, United Kingdom Diagnosis of Helieobaeterpyloriinfection by detection of a n t i g e n s i n stool specimens. (Abstract# G1070) A Prada, G Gialluca, A Bortoli, M Re and C Gozzini. Milan, Italy

Itelicobaeterpylori a n t i g e n i n stool specimens: a

new

enzyme i m m u n o a s s a y . (Abstract# G0354) A Cavallero, G Mezzi, L Fanti, G Gesu, C Bonato and E Masci. Milan, Italy C o m p a r i s o n of a g a r d i l u t i o n v e r s u s E-test ® i n the i n t e r p r e t a t i o n of a n t i m i c r o b i a l s u s c e p t i b i l i t y to H. pylori. (Abstract# G1344) A Weissfeld, S Kidd, C Fludas, P Greski-Rese, N Siepman and B Hunt. Houston, TX and Deerfield, IL

Helieobaeterpylori a n t i m i c r o b i a l susceptibilities - a tale of two cities. (Abstract# G0959) D Morton, R Ahmed, R Ally, Segal and KD Bardhan. Rotherham, United Kingdom and Witwatersrand, Africa Helieobaeterp.vlori r e s i s t a n c e to c l a r i t h r o m y c i n , metronidazole, amoxicillin, tetracycline, a n d trovafloxacin i n The N e t h e r l a n d s . (Abstract# G0401) YJ Debets-Ossenkopp, AJ Herscheid, EJ Kuipers, JG Kusters and CMJE Vandenbroucke-Gratds. Amsterdam, The Netherlands E v o l u t i o n of ttelicobacterpylori a n t i b i o t i c r e s i s t a n c e i n J a p a n (1985-1997). (Abstract# G1240) S Takahashi, T Itoh, H Ninomiya, S Hoshiya, K Watanabe, K Tokunaga, A Tanaka, N Nakamura, N Masubuchi, M Shingaki and S Saito. Tokyo, Japan Co-detection of Helieobaeterpylori a n d of its r e s i s t a n c e to c l a r i t h r o m y i n b y P C R d i r e c t l y from biopsy material. (Abstract# Gl158) E Sevin, D Lamarque, JC Delchier, CJ Soussy and J Tankovic. Creteil, France

DDW Poster of Distinction: When does simple h e a r t b u r n become a disease? (Abstract# GU66) MJ Shaw, SA Adlis, TJ Beebe, NJ Talley and RL Kane. Minneapolis, MN and Penrith, Australia A n e v a l u a t i o n of u t i l i t y m e a s u r e m e n t i n gastroesophageal reflux disease. (Abstract# G0477) A Ethiopia, JC Gregor, HG Preiksaitis, RPG Reynolds and BG Feagan. London, Canada Esophageal m o t o r disorders i n d i a b e t e s m e l l i t u s p a t i e n t s with slight c a r d i o v a s c u l a r n e u r o p a t h y . (Abstract# G0952) F Mora, I Lluch, J Ascaso, I Pascual, J Sempere, M Minguez, A Pefia and A Benages. Valencia, Spain Ineffective esophageal m o t i l i t y is m o r e p r e v a l e n t i n reflux p a t i e n t s w i t h r e s p i r a t o r y symptoms. (Abstract# G0506) YM Fouad, R Khoury, JG Hatlebakk, PO Katz and DO Castell. Philadelphia, PA Assessment of s y m p t o m s e v e r i t y a n d c h e m o s e n s i t i v i t y to acid i n elderly versus y o u n g p a t i e n t s w i t h gastroesophageal reflux disease. (Abstract# G0488) R Fass, G Pulliam, HS Garewal and RE Sampliner. Tucson, AZ Correlation of a m b u l a t o r y 24-hour esophageal p H m o n i t o r i n g r e s u l t s with s y m p t o m i m p r o v e m e n t i n p a t i e n t s w i t h n o n c a r d i a c chest p a i n d u e to gastroesophageal reflux disease. (Abstract# G3099) R Fass, MB Fennerty, C Johnson, E Camargo and RE Sampliner. Tucson, AZ and Portland, OR The effect of r e p e t i t i v e b a l l o o n d i s t e n s i o n s o n s e n s o r y i n t e n s i t y r a t i n g i n the p r o x i m a l a n d distal esophagus of n o r m a l subjects a n d p a t i e n t s w i t h g a s t r o e s o p h a g e a l reflux disease. (Abstract# G3100) R Fass. Tucson, AZ A U K d a t a b a s e for a d m i n i s t r a t i o n , a u d i t a n d a n a l y s i s of d a t a from esophageal f u n c t i o n tests. (Abstract# G0479) DF Evans, FD Castillo, C Smith, T Dehn, E Yazaki, J Stratford, A Gemmell and DL Wingate. London, Newcastle, Southampton, Reading and High Wycombe, United Kingdom Long term follow-up of gastroesophageal reflux disease i n children. (Abstract# Gl117) T Ruuska, M Ashorn, H Koivu, L Aine, R Karikoski and M M~ki. Tampere, Finland

Diagnosis of g a s t r i c H. pjrlori u s i n g a self-contained ingestible pH p r o b e w i t h r a d i o t r a n s m i t t e r . (Abstract# Gl159) M Seyedi, G Ghuloom and AF Cutler. Detroit, MI

The p r e v a l e n c e of gastroesophageal reflux disease i n J a p a n : prospective e v a l u a t i o n w i t h e n d o s c o p y i n 5629 subjects. (Abstract# G0688) Y Kashiwagi, N Furukawa, T Koyama, H Morita, T Ohyama, H Sakata, R Iwakiri and K Fujimoto. Saga, Japan

ESOPHAGEAL, GASTRIC, AND DUODENAL DISORDERS - - G A S T R O E S O P H A G E A L R E F L U X DISEASE

H e a r t b u r n i n Belgium: a p o p u l a t i o n - b a s e d epidemiological study. (Abstract# G0411) M Deltenre, M Capelle, P Van Wilder, C Jonas and E De Koster. Brussels, Belgium

M a n i f e s t a t i o n s of g a s t r o e s o p h a g e a l reflux disease a r e c o m m o n i n p a t i e n t s e x p e r i e n c i n g h e a r t b u r n o n at least two to four days p e r week. (Abstract# G0830) D Levine, R Carlsson, J Whipple, B Joelsson and A Merck. Wayne, PA and M61ndal, Sweden

P r e v a l e n c e of gastroesophageal reflux disease i n fir,

pyIori-positive peptic ulcer disease a n d the i m p a c t of e r a d i c a t i o n t h e r a p y . (Abstract# G1001) HJ O'Connor, C McGee, N Mehana and K Cunnane. Tullamore, Ireland Clinical s p e c t r u m of gastroesophageal reflux disease after HP e r a d i c a t i o n i n p a t i e n t s w i t h d u o d e n a l ulcers. (Abstract# G0930) S Michopoulos, P Tsibouris, A Balta, H Bouzakis, G Galanopoulos and N Kralios. Athens, Greece

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The a p p e a r a n c e of GORD i n p a t i e n t s w i t h d u o d e n a l u l c e r after e r a d i c a t i o n of Hellvobaeterpylarlinfection: a four y e a r p r o s p e c t i v e study. (Abstract# G0429) F Di Maria, N Dal BS, S Salandin, A Buda, A Pilotto, S Kusstatscher, G Leandro, G Battaglia, F Vianello, M Cassaro, S Vigneri, G Delle Fave and M Rugge. Venice, Rome, Padua and Palermo, Italy Are g a s t r o e s o p h a g e a l reflux disease a n d peptic esophagitis a c o m p l i c a t i o n of the e r a d i c a t i o n of Helieobacterpyloriin p a t i e n t s with d u o d e n a l ulcer? (Abstract# G0324) JF Bretagne, P Barth~l~my, A Caekaert and Hepysode. Rennes and Ruefl-Malmaison, France

Helleobacterpylori a n d esophageal acid exposure i n GERD. (Abstract# G1058) FTM Peters, EJ Kuipers, S Ganesh, WJ Sluiter, EC Kiinkenberg-Knol,CBHW Lamers and JH Kleibeuker. Groningen, Leiden and Amsterdam, The Netherlands Symptom-reflux a s s o c i a t i o n i n p a t i e n t s with GERD. (Abstract# G0996) EC Niemantsverdriet, R Breumelhof, R Timmer and AJPM Smout. Nieuwegein and Utrecht, The Netherlands P a t h o l o g i c a l reflux is less c o m m o n a n d less severe i n A s i a n p a t i e n t s w i t h atypical chest p a i n t h a n t h e i r A m e r i c a n c o u n t e r p a r t s . (Abstract# G0615) KY Ha, N Feldman, H Mantes, MJ Sossenheimer, J Van Dam and DL Carr-Locke. Boston, MA M u l t i c e n t e r s t u d y of endoscopic f i n d i n g s i n p a t i e n t s with h e a r t b u r n . (Abstract# G0732) M Kline, T Zarchy, D Ershoff, D Abrahm and G Madokoro. Los Angeles and Irvine, CA Classic s y m p t o m s are h i g h l y p r e d i c t i v e of g a s t r o e s o p h a g e a l reflux disease. (Abstract# Gl143) V Saxena, L Fiennes, JM Bland, TC Northfield and PJ Howard. London, United Kingdom The use of l i q u i d or solid meals d u r i n g a m b u l a t o r y bile reflux m o n i t o r i n g i n m a n . (Abstract# G0304) R Bisschops, E Setijoso, J Tack, T Lerut and J Janssens. Leuven, Belgium Effect of isocaloric low- a n d high-fat meals o n g a s t r o e s o p h a g e a l reflux. (Abstract# G1052) C Pehl, A Weizenh6fer, A Pfeiffer, B Wendl, T Schmidt and W Schepp. Munich, Germany

DDW Poster of Distinction: Effect of acid a n d a c i d - p e p s i n s o l u t i o n s o n esophageal l u m i n a l surface h y d r o p h o b i c i t y . (Abstract# G0263) RL Barclay, MG Buell, WG Paterson and GP Morris. Kingston, Canada Chloride t r a n s p o r t i n r a b b i t e s o p h a g e a l epithelial cells. (Abstract# G0209) S Abdulnour-Nakhoul, C Caymaz-Bor and RC Orlando. New Orleans, LA Visible esophagitis i n o p e n access gastroscopy p a t i e n t s is r e l a t e d to l e n g t h of dyspeptic history. (Abstract# G0569) JR Greenaway, FJ Vilar, GN Tayyab, GE Cann and PA Cann. Middlesbrough, United Kingdom

DDW Poster of Distinction: P a t t e r n s of gas a n d l i q u i d reflux i n p a t i e n t s with gastroesophageal reflux disease. (Abstract# Gl185) D Sifrim, RH Holloway, J Silny, T Lerut and J Janssens. Leuven, Belgium; Adelaide, Australia and Aachen, Germany H i a t a l h e r n i a size is t h e p r i n c i p a l d e t e r m i n a n t of esophagitis i n p a t i e n t s w i t h s y m p t o m a t i c gastroesophageal reflux disease. (Abstract# G0666) MP Jones, S Sloan, PJ Kahrilas, M Chen and JC Rabine. Dayton, OH and Chicago, IL Gastroesophageal reflux i n p a t i e n t s w i t h obstructive sleep a p n e a s y n d r o m e . (Abstract# G0918) V Meister, E Almus, O Schmalz, M Orth, I Greying and K Rasche. Bochum, Germany Esophageal a n d r e s p i r a t o r y m a n o m e t r i c s i n a s t h m a t i c s with GER. (Abstract# G0586) SM Harding, LF Johnson and MR Guzzo. Birmingham, AL The r e l a t i o n s h i p b e t w e e n GERD a n d OSAS a n d effect of a n t i r e f l u x therapy. (Abstract# G1373) GH Xiao, ZF Wang, MY Ke and SZ Huang. Beijing, PR China S e c o n d a r y esophageal peristalsis is p r e s e r v e d i n p a t i e n t s with p o s t e r i o r laryngitis. (Abstract# G1291) S Ulualp, R Toohill and R Shaker. Milwaukee, WI Revelations a b o u t 24 h o u r a m b u l a t o r y p h a r y n g e a l pH m o n i t o r i n g . (Abstract# G1290) S Ulualp, R Toohill, R Hoffmann, RC Arndorfer and R Shaker. Milwaukee, WI

DDW Poster of Distinction: C o n t r i b u t i o n of acid a n d bile reflux to symptoms i n p a t i e n t s w i t h g a s t r o e s o p h a g e a l reflux disease. (Abstract# G0745) G Koek, J Tack, A Degreef, T Lerut and J Janssens. Leuven, Belgium

DDW Poster of Distinction: E s o p h a g o p h a r y n g e a l d i s t r i b u t i o n of refluxed gastric acid i n p a t i e n t s w i t h vocal cord n o d u l e a n d c h r o n i c sinusitis. (Abstract# G1288) S Ulualp, R Toohill, B Massey, RC Arndorfer, WJ Hogan and R Shaker. Milwaukee, WI

P e r c e n t a g e of t i m e versus surface above cut-off i n the a n a l y s i s of bile reflux m o n i t o r i n g i n man. (Abstract# G0393) R Cuomo, J Tack, G Koek, A Degreef, R HoUoway, T Lerut and J Janssens. Leuven, Belgium

Pharyngo-UES c o n t r a c t i l e reflex i n p a t i e n t s with p o s t e r i o r laryngitis. (Abstract# G1289) S Ulualp, R Toohill, M Kern and R Shaker. Milwaukee, WI

DDW Poster of Distinction:

Gastroesophageal reflux disease a n d c h r o n i c sinusitis: a n e w association? (Abstract# G0419) JK DiBaise, J Huerter and EMM Quigley. Omaha, NE

E s o p h a g i t i s a n d bile reflux i n m e c h a n i c a l l y v e n t i l a t e d p a t i e n t s . (Abstract# G1356) A Wilmer, J Tack, E Frans and H Bobbaers. Leuven, Belgium

C a n symptoms p r e d i c t esophageal acid exposure i n GERD? (Abstract# G0418) JK DiBaise, J Lof and EMM Quigley. Omaha, NE Effect of sleep p o s i t i o n o n n o c t u r n a l acid reflux. (Abstract# G0685) K Kaput, N Trudgill, L Smith, D Taylor and S Riley. Sheffield, United FAngdom

P210PROGRAMOF THEANNUALMEETING

I n t r a - s u b j e c t v a r i a b i l i t y of d u o d e n o g a s t r i c reflux. (Abstract# G0872) DK Manifold, REK Marshall, A Anggiansah and WJ Owen. London, United Kingdom I n t r a - g a s t r i c v a r i a t i o n of d u o d e n o g a s t r i c reflux. (Abstract# G0871) DK Manifold, REK Marshall, A Anggiansah and WJ Owen. London, United Kingdom Histological a b n o r m a l i t i e s at t h e gastroesophageal j u n c t i o n : c o r r e l a t i o n w i t h acid a n d bile reflux. (Abstract# G0321) DJ B0wrey, GWB Clark, E Steckdale, GT Williams and PD Carey. Cardiff, United Kingdom Role of s a l i v a r y m u c i n i n the p r o t e c t i o n of esophageal m u c o s a from acid a n d p e p s i n - i n d u c e d i n j u r y . (Abstract# G0728) M Kinoshita, N Saito, E Kume, M Yasuda, K Okuyama, S Igarashi and H Narita. Saitama, Japan

GASTROENTEROLOGYVol. 114~No.4

P a n t o p r a z o l e 40 mg a n d 20 m g a r e e q u i v a l e n t i n p r e v e n t i o n of r e l a p s e of reflux esophagitis. (Abstract# G0474) J Esc0urr0u, R Fiasse, A Saggioro, D Vaira, H Geld0f, R Fischer and C Maier. Toulouse, France; Brussels, Belgium; Mestre and Bologna, Italy; Capelle, The Netherlands and Constance, Germany On d e m a n d t h e r a p y of reflux esophagitis - a s t u d y of symptoms, p a t i e n t satisfaction a n d q u a l i t y of life. (Abstract# G1352) I Wilhelmsen, JG Hatlebakk, S Olafsson and A Berstad. Bergen, Norway What is the p r e f e r r e d dose of l a n s o p r a z o l e i n t h e m a i n t e n a n c e t h e r a p y of reflux esophagitis? The r e s u l t s of a Dutch m u l t i - c e n t e r c o m p a r a t i v e trial. (Abstract# G0656) JBMJ Jansen, PWE Haeck, P Snel, TG Tan, BP Hazenberg, AMH Wetzels and C Harlaar. Nijmegen, The Netherlands

The i n f l u e n c e of g a s t r o p a r e s i s o n gastroesophageal reflux disease? (Abstract# G0772) S Kress, D Dorlars, A Buttmann, P Schauwecker and JF Riemann. Ludwigshafen, Germany

First comparison pantoprazole versus lansoprazole in hospital a n d p r i v a t e practice p a t i e n t s w i t h reflux esophagitis. (Abstract# G0454) J-L Dupas, P Houcke, G Giret-d'Orsay and R Samoyeau. Amiens and Lille, France

P r e s s u r e m o r p h o l o g y of the gastroesophageal j u n c t i o n after f u n d o p l i c a t i o n : h o w n o r m a l is it? (Abstract# G0835) S Lin, AE Spiess, M Manka, J Chen, RJ J0ehl and PJ Kahrilas. Chicago, IL

Meta-analysis of c o m p a r a t i v e t r i a l s for h e a l i n g erosive esophagitis w i t h p r o t o n p u m p i n h i b i t o r s a n d H 2receptor a n t a g o n i s t s . (Abstract# G0633) J-Q Huang and RH Hunt. Hamilton, Canada

M a n o m e t r y does n o t p r e d i c t d y s p h a g i a after laparoscopic a n t i - r e f l u x surgery. (Abstract# G1308) H van der Walt and JB van den Bogaerde. Pretoria, South Africa

Effect of long t e r m m a i n t e n a n c e w i t h p a n t o p r a z o l e o n s e r u m g a s t r i n a n d histology p a r a m e t e r s i n severe acidpeptic disease. (Abstract# G0303) A Bishop, H R0manska, J Polak, K Bardhan, W Ng, R Fischer and A Schneider. London and R0therham, United Kingdom; Constance, Germany

Non-esophageal g a s t r o i n t e s t i n a l s y m p t o m s p r e d i c t worse r e s u l t s after f u n d o p l i c a t i o n for gastroesophageal reflux disease. (Abstract# G0837) CD Lind, RH Clements, H Mertz, M Holzman, KW Sharp and WO Richards. Nashville, TN

C o m p a r i s o n of i n t r a v e n o u s w i t h oral p a n t o p r a z o l e i n symptom relief a n d h e a l i n g of r e f l u x esophagitis. (Abstract# G0515) I Fumagalli, M Klein and R Fischer. Locarno, Switzerland and Constance, Germany

Laparoscopic h e l l e r m y o t o m y w i t h o u t f u n d o p l i c a t i o n improves s y m p t o m s of g a s t r o e s o p h a g e a l reflux i n p a t i e n t s w i t h achalasia. (Abstract# G0836) CD Lind, RH Clements, P Wang, H Mertz, M Holzman, KW Sharp and WO Richards. Nashville, TN

Eleven years' experience of c o n t i n u o u s m a i n t e n a n c e t r e a t m e n t w i t h omeprazole i n GERD p a t i e n t s . (Abstract# G0735) EC Klinkenberg-Knol. Amsterdam, The Netherlands

Experiences w i t h l a p a r o s c o p i c Nissen versus laparoscopic T o u p e t a p p r o a c h to "giant" p a r a e s o p h a g e a l h e r n i a t i o n . (Abstract# G0800) RJ Landreneau, RJ Wiechmann, P McKesey, TS Santucci, RS Macherey, MK Gergnson, KS Naunheim and MJ Mack. Pittsburgh, PA; Chicago, IL; St Louis, MO and Dallas, TX

C o m p a r i s o n of omeprazole 10 m g a n d r a n i t i d i n e 150 mg b.i.d, i n t h e long t e r m t r e a t m e n t of reflux esophagitis. (Abstract# G0498) HPM Festen, BE Schenk, TG Tan, P Snel and GF Nelis. Den Bosch, Amsterdam, Hengelo and Zwolle, The Netherlands

Five-year follow-up of p a t i e n t s after laparoscopic Nissen f u n d o p l i c a t i o n . (Abstract# G0734) PJ Klingler, RA Hinder, NR F10ch, SA Branten, MH Seelig and SL Smith. Jacksonville, FL

Cisapride i m p r o v e s p u l m o n a r y f u n c t i o n tests i n p a t i e n t s w i t h gastroesophageal reflux a n d c h r o n i c r e s p i r a t o r y symptoms. (Abstract# G0712) R Kh0ury, V Pa01etti, J Cohn, M Gideon, N Bracy, P Katz and D Castell. Philadelphia, PA

A n objective m e a s u r e of the s h o r t e n e d esophagus p r i o r to a n t i r e f l u x surgery. (Abstract# G0660) BA Jobe, KD Horvath, RW Bennetts and LL Swanstrom. Portland, OR P a n t o p r a z o l e 20 m g is as effective as p a n t o p r a z o l e 40 m g i n p r e v e n t i o n of r e l a p s e of reflux esophagitis. (Abstract# G1066) K Plein, J H0tz, H Wurzer, I Fumagaili, H Tenor and A Schneider. Celle and Constance, Germany; Graz, Austria and Locarno, Switzerland

DDW Poster of Distinction: Influence of body p o s i t i o n o n n i g h t t i m e r e c u m b e n t reflux i n p a t i e n t s with GERD. (Abstract# G0713) R Kh0ury, M Mohiuddin, P Katz and D Castell. Philadelphia, PA P a n t o p r a z o l e 40 m g versus omeprazole 20 m g i n the t r e a t m e n t of reflux esophagitis: r e s u l t s of a F r e n c h m u l t i c e n t r i c d o u b l e - b l i n d c o m p a r a t i v e trial. (Abstract# G1324) F Vicari, J Belin, L Marek and the CREGG. Nancy and Meudon-La For~t, France

April 1998

PROGRAMOF THEANNUALMEETINGP211

A G A P O S T E R S E S S I O N - - W E D N E S D A Y , M A Y 20, 1998 O m e p r a z o l e 20 m g b.d. r e d u c e s reflux of bile to b o t h the e s o p h a g u s a n d t h e u p p e r gastric body. (Abstract# G0887) REK Marshall, A Anggiansah, DK Manifold, WA Owen and WJ Owen. London, United Kingdom

A r g o n p l a s m a c o a g u l a t i o n i n p a t i e n t s with Barrett's esophagus. (Abstract# G0888) W-R Martin, C Benz, R Jakobs and JF Riemann. Ludwigshafen, Germany

Is t h e r e a n OED (optimal effective dose) of P P I i n the l o n g t e r m m a i n t e n a n c e t h e r a p y of GERD? Results after 5-8 years. (Abstract# G0261) S Bank, L Brigante, N Schulman and D Magier. New Hyde Park, NY

P h o t o d y n a m i c t h e r a p y of B a r r e t t ' s esophagus w i t h high-grade d y s p l a s i a a n d early cancer. (Abstract# G0558) L Gossner, A May, R Sroka, T Rabenstein, TH Schneider, EG Hahn, M Stolte and C Ell. Wiesbaden and Erlangen, Germany

Physiologic a n d s y m p t o m a t i c r e s p o n s e s to cisapride t r e a t m e n t i n older a d u l t s w i t h GERD. (Abstract# G1021) WC Orr, J McClanahan, M Zhang and JDZ Chen. Oklahoma City, OK B e d t i m e r a n i t i d i n e v e r s u s omeprazole for control of n o c t u r n a l acid. (Abstract# Gl102) M Robinson, S Rodriguez-Stanley, J Filinto, S Zubaidi, PB Miner, R McIsaac and A Ciociola. Oklahoma City, OK and Research Triangle Park, NC Daily or severe h e a r t b u r n p r e d i c t s a favorable r e s p o n s e to r a n i t i d i n e 150 m g b i d i n otherwise h e a l t h y a n t a c i d users. (Abstract# G0458) DL Earnest, M Robinson, S Redriguez-Stanley and A Ciociola, Tucson, AZ, Oklahoma City, OK and Research Triangle Park, NC A cost-effectiveness a n a l y s i s of p r e s c r i b i n g strategies i n

m a n a g i n g h e a r t b u r n . (Abstract# G0538) LB Gerson, AS Robbins and GT Triadafflopoulos. Stanford, CA Histology a n d safety p a r a m e t e r s d u r i n g long t e r m m a i n t e n a n c e w i t h p a n t o p r a z o l e i n severe acid-peptic disease. (Abstract# G0243) C Athmann, I Mander, G Brunner, W Ng, H Heinze, R Fischer and A Schneider. Hanover and Constance, Germany A prospective randomised controlled trial comparing d a i l y a l t e r n a t e d a y a n d PRN l a n s o p r a z o l e i n the m a i n t e n a n c e t r e a t m e n t of esophagitis. (Abstract# Gl112) C Roseveare, P Goggin, P Patel, J Kimble, J Elliot and H Shepherd. Winchester, United Kingdom Gastric a n t i s e c r e t o r y d r u g - i n d u c e d a c h l o r h y d r i a causes decreases i n s e r u m v i t a m i n B12 levels i n p a t i e n t s w i t h Zollinger-Ellison s y n d r o m e : a prospective study. (Abstract# Gl156) J Serrano, F Gibril, F Yu, SU Goebel and RT Jensen. Bethesda, MD Cost-effectiveness of d i a g n o s t i c strategies to c o n f i r m or exclude GERD as a n e x a c e r b a t i n g factor i n a s t h m a : i d e n t i f i c a t i o n of critical variables. (Abstract# G1002) JB O'Connor, ME Singer and JE Richter. Cleveland, OH ESOPHAGEAL, GASTRIC, AND DUODENAL DISORDERS - - BARRETT'S ESOPHAGUS Risk of a d e n o c a r c i n o m a i n short- a n d long-segment B a r r e t t ' s esophagus: is s h o r t e r b e t t e r ? (Abstract# G1003) JB O'Connor, GW Falk and JE Richter. Cleveland, OH E n d o s c o p i c t h e r a p y of B a r r e t t ' s esophagus u s i n g a r g o n p l a s m a c o a g u l a t i o n . (Abstract# G1069) M P0rthun, B Brand, F Thonke, S Bohnacker, U Seitz, KF Binmoeller, T v Schrenck, U Matsui and N Soehendra. Hamburg, Germany

D D W Poster of Distinction: Complete reversal of B a r r e t t ' s esophagus: b i o m a r k e r s t u d i e s i n d i c a t e d e c r e a s e d c a n c e r r i s k i n a biologically n o r m a l s q u a m o u s e p i t h e l i u m . (Abstract# G0526) H Garewal, L Ramsey, P Sharma, R Fass, K Kraus and R Sampliner. Tucson, AZ

Helicobacterpyloriis associated w i t h i n t e s t i n a l m e t a p l a s i a i n the p r o x i m a l a n d distal s t o m a c h b u t n o t w i t h i n t e s t i n a l m e t a p l a s i a i n B a r r e t t ' s esophagus. (Abstract# G0552) JJ Going, H Kasem, H Ihmaidat, C MacKay, A Foulis, R Carter and RC Stuart. Glasgow, Scotland R o u t i n e biopsy of t h e GE j u n c t i o n : is it w o r t h the time s p e n t ? (Abstract# G1049) M Peck-Radosavljevic, A PfispSk, A Gangl, R P6tzi and G Oberhuber. Vienna, Austria I n c i d e n c e of d y s p l a s i a i n s h o r t - s e g m e n t Barrett's esophagus: a prospective 3-year follow-up. (Abstract# G0663) M Johnston and P Schoenfeld. Bethesda, MD I n c i d e n c e of a d e n o c a r e i n o m a a n d d y s p l a s i a i n a c o m m u n i t y b a s e d p o p u l a t i o n w i t h B a r r e t t ' s esophagus. (Abstract# G1205) DJ Sprung. Orlando, FL Clinical, esophageal m o t i l i t y a n d p H profiles i n B a r r e t t ' s esophagus of children. An I t a l i a n m u l t i c e n t e r study. (Abstract# G0390) S Cucchiara, MT Franc0, L Dall'Oglio, S Luzzani, C De Giac0mo, P Lerro, M Cinquetti, G Gaudiello and G Boccia. Naples, Milan, Rome, Turin, Pavia and Verona, Italy

In vitro f u n c t i o n of t h e h u m a n lower esophageal s p h i n c t e r i n B a r r e t t ' s esophagus. (Abstract# GU86) SD Staid, J Dent and LA Blackshaw. Adelaide, South Australia B a r r e t t ' s esophagus. P r e v a l e n c e a n d size of h i a t a l h e r n i a . (Abstract# G0338) AJ Cameron. Rochester, MN Without h i a t a l h e r n i a , B a r r e t t ' s h a r b o r i n g high grade dysplasia is c o n f i n e d to the GE j u n c t i o n . (Abstract# G1201) SJ S0ntag, T Schnell, G Chejfec, T Miller, C Kurucar, S O'C0nnell, J Seidel, G Levine, J Karpf and L Brand. Hines and Mayw0od, IL Hiatal h e r n i a d e t e r m i n e s the l o c a t i o n of the esophageal a d e n o c a r c i n o m a : B a r r e t t ' s versus t h e GE j u n c t i o n . (Abstract# Gl198) SJ Sontag, T Schnell, G Chejfec, C Kurucar, S O'Connell, G Levine, J Karpf, L Brand and J Seidel. Hines and Maywood, IL

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The l e n g t h of B a r r e t t ' s d e p e n d s e n t i r e l y o n p r e s e n c e or a b s e n c e of h i a t a l h e r n i a . (Abstract# G1200) SJ Sontag, T SchneU, G Chejfec, T Miller, C Kuruear, S O'Connell, J Seidel, G Levine, J Karpf, L Brand and A Metz. Hines and Maywood, IL

E a r l y diagnosis of s h o r t s e g m e n t B a r r e t t ' s esophagus using an immunohistochemical marker: an i n t e r i n s t i t u t i o n a l b l i n d e d study. (Abstract# G0571) LH Griffel, AP Weston, NA Karalnik, PS Amenta and KM Das. New Brunswick, NJ and Kansas City, MO

High grade d y s p l a s i a still is n o t a n i n d i c a t i o n f o r s u r g e r y i n p a t i e n t s w i t h B a r r e t t ' s esophagus: a n u p d a t e . (Abstract# Gl149) T Schnell, SJ Sontag, G Chejfec, C Kurucar, S O'Connell, G Levine, J Karpf, K Adelman, L Brand and J Seidel. Hines and Maywood, IL

P r e v a l e n c e of Barrett's esophagus i n a V A h o p i t a l

Microscopic B a r r e t t ' s esophagus: r e l a t i o n s h i p to acid a n d bile reflux i n m a n . (Abstract# G1316) W Van Vaerenbergh, J Tack, K Geboes, AM Gevers, P Rutgeerts, T Lerut and J Janssens. Leuven, Belgium Esophageal acid a n d bile e x p o s u r e i n short s e g m e n t B a r r e t t ' s esophagus. (Abstract# G0857) C MacKay, H Kasem, JJ Going, H Ihmaidat, J MacKenzie, R Carter and RC Stuart. Glasgow, Scotland Duodeno-gastro(-esophageal) reflux i n reflux disease a n d i n B a r r e t t ' s esophagus. (Abstract# G1210) JWA Straathof, S Farsi, CBHW Lamers and AAM Masclee. Leiden, The Netherlands Effect of esophageal l o c a t i o n o n c h e m o s e n s i t i v i t y to acid i n p a t i e n t s w i t h B a r r e t t ' s esophagus. (Abstract# G0849) W Lunt, G Pulliam, HS Garewal, RE Sampliner and R Fass. Tucson, AZ

population using an immunohistochemical

marker: an

i n t e r i n s t i t u t i o n a l b l i n d e d study. (Abstract# G0572) LH Griffel, V Mohan, NA Karalnik, K Nandiwada, PS Amenta and KM Das. New Brunswick and Lyons, NJ The first y e a r of the U.K. N a t i o n a l B a r r e t t ' s E s o p h a g u s Registry. (Abstract# G0355) CPJ Caygill, PI Reed, A Watson, A McIntyre and MJ Hill. Slough, London and High Wycombe, United Kingdom R e g e n e r a t i o n of s q u a m o u s m u c o s a after a r g o n p l a s m a c o a g u l a t i o n of B a r r e t t ' s e p i t h e l i u m . (Abstract# G0958) H Mt~rk, O Al-Taie, M Kraus, H Kreipe, T Barth, F Jakob and M Scheurlen. Wtirzburg, Germany P r o t o n p u m p i n h i b i t o r s r e d u c e cell cycle a b n o r m a l i t i e s i n B a r r e t t ' s esophagus. (Abstract# G0235) N Arber, W Yasui, M Umansky, F Konikoff, N Harris, C Lightdale, H Hibshoosh, A Neugut, P Holt, I Weinstein and E Tahara. Tel Aviv, Israel; New York, NY and Hiroshima, Japan Is specialized i n t e s t i n a l m e t a p l a s i a at t h e esophagogastric j u n c t i o n associated w i t h microsatellite i n s t a b i l i t y ? (Abstract# G0909) NI McDougall, CM Gleeson, JM Sloan, SEH Russell and JSA Collins. Belfast, Northern Ireland

Bile salts i n d u c e or b l u n t cell p r o l i f e r a t i o n i n Barrett's esophagus i n a n a c i d - d e p e n d e n t fashion. (Abstract# G0697) B Kaur, R Ouatu-Lascar, RC Fitzgerald, MB Omary and G Triadafilopoulos. Palo Alto, CA

F r e q u e n c y of i n t e s t i n a l m e t a p l a s i a at different sites i n the esophagus a n d stomach. (Abstract# G0655) R Jain, D Aquino, WV Harford, E Lee and SJ Spechler. Dallas, TX

Salivary growth factors are n o t deficient i n p a t i e n t s w i t h Barrett's esophagus. (Abstract# G0759) KR Kongara, EE Softer, GW Varilek, J J Schmidt and DL DiMartino. Cleveland, OH and Lexington, KY

Cardiac e p i t h e l i u m is f o u n d i n f r e q u e n t l y i n t h e gastric cardia. (Abstract# G0654) R Jain, D Aquino, WV Harford, E Lee and SJ Spechler. Dallas, TX

DDW Poster of Distinction:

The i n t e s t i n a l p h e n o t y p e of the c o l u m n a r l i n e d (Barrett's) esophagus. (Abstract# G0360) P Chaves, A Suspiro, P Cardoso, A Dias Pereira, JC Mendes de Almeida, C Nobre Leit~o and J Soares. Lisbon, Portugal

Cellular o r i g i n of B a r r e t t ' s e p i t h e l i u m : a critical a n a l y s i s u s i n g a n o v e l b i o m a r k e r . (Abstract# G0399) KM Das, N Botros and PS Amenta. New Brunswick, NJ The elevated c o n t e n t of e p i d e r m a l g r o w t h factor a n d t r a n s f o r m i n g g r o w t h factor-a, a n d d i m i n i s h e d p r o s t a g l a n d i n E 2 i n f a s t i n g gastric j u i c e i n p a t i e n t s with Barrett's esophagus: t h e i r p o t e n t i a l p a t h o g e n e t i c implications. (Abstract# G1407) T Zbroch, AP Weston, AS Badr, M Marcinkiewicz, C Poplawski and J Sarosiek. Kansas City, KS and Kansas City, MO The failure w i t h i n the c o m p e n s a t o r y esophageal m u c o s a l p r o t e c t i v e m e c h a n i s m s i n p a t i e n t s with B a r r e t t ' s esophagus as p o t e n t i a l c o n t r i b u t o r y factor to the d e v e l o p m e n t of m u c o s a l pathology. (Abstract# G1408) T Zbroch, M Marcinkiewicz, C Poplawski, RL Brown, RW McCallum and J Sarosiek. Kansas City, KS I m p a i r m e n t i n s a l i v a r y b u f f e r i n g capacity i n p a t i e n t s w i t h Barrett's esophagus: its p o t e n t i a l p a t h o g e n e t i c implications. (Abstract# G0882) M Marcinkiewicz, T Zbroch, C Poplawski, RL Brown and J Sarosiek. Kansas City, KS

DDW Poster of Distinction: Bax e x p r e s s i o n increases w i t h d y s p l a s i a i n B a r r e t t ' s esophagus. (Abstract# G1362) TA Woodward, PD Klingler, PV Genc0 and JT Wolfe. Jacksonville, FL Possible p 5 3 - i n d e p e n d e n t e x p r e s s i o n of p21 wAF/Cml i n Barrett's esophagus. (Abstract# G2916) TA Woodward, PJ Klingler, PV Genco and JT Wolfe. Jacksonville, FL E n d o g e n o u s r a d i c a l scavengers i n B a r r e t t ' s esophagus.

(Abstract# GU28) JT Salminen, OJ R~mS, M Ffirkkil~ and JA Salo. Helsinki, Finland ESOPHAGEAL, GASTRIC, AND D U O D E N A L DISORDERS - - N O N R E F L U X E S O P H A G E A L DISEASE E r a d i c a t i o n of esophageal varices: a s s e s s m e n t b y e n d o s o n o g r a p h y . (Abstract# G0407) J Delarive, G Dorta, P Pescatore, P Wiesel, J Martinek, J Hess and AL Blum. Lausanne, Switzerland

April 1998

PROGRAM OF T H E ANNUAL MEETING P213

A G A P O S T E R S E S S I O N - - W E D N E S D A Y , MAY 20, 1998 I n t r a l e s i o n a l steroids a u g m e n t t h e effect of endoscopic d i l a t i o n i n c o r r o s i v e - i n d u c e d esophageal strictures. (Abstract# G0740) R K0chhar, PVJ Sriram and K Singh, Chandigarh, India

On-screen p r e s s u r e volume: a r a p i d a n d sensitive m a n o m e t r i c m e a s u r e m e n t available from t o p o g r a p h i c methods. (Abstract# G0224) A Alrakawi and RE Clouse. St Louis, MO

E n d o s c o p i c d i l a t a t i o n is safe a n d effective i n t r e a t i n g t h e e s o p h a g e a l s t r i c t u r e s of epidermolysis bullosa. (Abstract# G0913) J Meenan and RPH Thompson. London, United Kingdom

The s p e c t r u m of e o s i n o p h i l i c esophagitis i n children. (Abstract# G1019) SR Orenstein, H Mousa, C Di Lorenzo, SA Koc0shis, PE Putnam, JF del Rosario, L Sigurdss0n and TM Shalaby. Pittsburgh, PA

L y e - i n d u c e d esophagitis: course a n d follow-up of 29 p a t i e n t s . (Abstract# Gl121) MYFA Safieh. Nablus, Israel A n o v e l a p p r o a c h to the t r e a t m e n t of s y m p t o m a t i c Schatzki r i n g s . (Abstract# G1086) CW Randall. San Antonio and Fredericksburg, TX A s p i r a t i o n o n modified b a r i u m swallow: r e l a t i o n s h i p of e x a m i n a t i o n m a t e r i a l s a n d clinical implications. (Abstract# G0365) MYM Chen, LG Gilbert, DJ Ott and DW Gelfand. WinstonSalem, NC Long t e r m r e s u l t s of p n e u m a t i c d i l a t i o n for esophageal achalasia. A 20-year e x p e r i e n c e i n 304 patients. (Abstract# G0536) R Germain and R Fiasse. Brussels, Belgium S y m p t o m i m p r o v e m e n t alone is n o t sufficient to assess the o u t c o m e of p n e u m a t i c d i l a t i o n i n achalasia. (Abstract# G1294) MF Vaezi, ME Baker and JE Richter. Cleveland, OH B o t u l i n u m t o x i n i n j e c t i o n s for a c h a l a s i a c a n a p p r o x i m a t e t h e s h o r t t e r m efficacy of a single p n e u m a t i c d i l a t i o n : a s u r v i v a l analysis approach. (Abstract# G1071) C Prakash, KE Freedland, MF Chan and RE Clouse. St Louis, MO Q u a l i t y of life a m o n g a c h a l a s i a p a t i e n t s t r e a t e d with b o t u l i n u m t o x i n i n j e c t i o n or p n e u m a t i c dilatation. (Abstract# G0925) H Meshkinpour, P Nguyen, D Bastas and KJ Chang. Irvine, CA

DDW Poster of Distinction: The effects of p r e v i o u s t r e a t m e n t o n the r e s u l t s of m y o t o m y for achalasia. (Abstract# G1046) MG Patti, CV Feo, M Arcerito, M De Pinto, M Ahmadi, J Tong, W Gantert, D Tyrrell and LW Way. San Francisco, CA A c o m p a r i s o n of g a s t r o e s o p h a g e a l reflux following t r e a t m e n t i n a c h a l a s i a p a t i e n t s . Myotomy versus forceful d i l a t a t i o n : late results. (Abstract# GU82) JP Shoenut, AB Micflikier, D Duerksen and CS Yaffe. Winnipeg, Canada P r o g r e s s i o n of t h e p s e u o d a c h a l a s i a m a n o m e t r i c p a t t e r n w i t h a d v a n c i n g c a n c e r s of gastric cardia. (Abstract# Gl196) CW Song, CD Kim, HJ Chun, HS Ryu, JH Hyun and PJ Kahrilas. Seoul, Korea and Chicago, IL M a n o m e t r i c c o r r e l a t e s of successful p n e u m a t i c d i l a t i o n for achalasia. (Abstract# Gl195) CW Song, SH Urn, CD Kim, HS Ryu, JH Hyun and PJ Kahrflas. Se0ul, Korea and Chicago, IL H y p e r t e n s i v e l o w e r esophageal s p h i n c t e r syndrome, clinical a n d m a n o m e t r i c follow-up. (Abstract# G1211) G Stuart, K DeVault and SR Achem. Jacksonville, FL

ESOPHAGEAL, GASTRIC, AND DUODENAL DISORDERS - - U P P E R G A S T R O I N T E S T I N A L DISORDERS Non-variceal u p p e r g a s t r o i n t e s t i n a l h e m o r r h a g e : models to p r e d i c t e a r l y discharge. (Abstract# G0843) DA Lloyd and RPE Reynolds. London, Canada P r e d i c t i n g early d i s c h a r g e following n o n - v a r i c e a l u p p e r g a s t r o i n t e s t i n a l h e m o r r h a g e . (Abstract# G0844) DA Lloyd and RPE Reynolds. London, Canada Stress u l c e r versus n o n - s t r e s s ulcer: clinical outcome of u l c e r b l e e d i n g d e p e n d s o n u n d e r l y i n g etiology. (Abstract# G0574) A Grodil, L DeGuzman, TL McCarter, RC Schilling, SA Khan, TD Lewis and YK Chen. Loma Linda, CA

DDW Poster of Distinction: Blood i n the s t o m a c h as a s u r r o g a t e for clinical e n d p o i n t s i n GI b l e e d i n g trials. (Abstract# G0598) GM Hawkey, WA Stack, AT Cole, RG Long, RFA Logan and CJ Hawkey. Nottingham, United Kingdom Bleeding d u o d e n a l u l c e r p a t i e n t s a r e associated with a p o l y m o r p h i s m of the e n d o t h e l a l c o n s t i t u t i v e n i t r i c oxide s y n t h a s e gene. (Abstract# Gl157) MT Serrano, A Lanas, E Piazuelo, S Santolaria, R Benito and R Sainz. Zaragoza, Spain Nadolol a d m i n i s t r a t i o n i n b l e e d i n g g a s t r o i n t e s t i n a l v a s c u l a r m a l f o r m a t i o n s . (Abstract# G0320) F Borteluzzi, G Chiozzini, P Pallini, G Betetto and A Saggior0. Venice-Mestre, Italy Elastic b a n d ligation: a n a l t e r n a t i v e t r e a t m e n t for gastric angiodysplasia. (Abstract# G0408) V Delis, V Balatsos, A Konstantinidis, A Germanopoulos, A Pantes, E Kanellopoulou and N Skandalis. Athens, Greece Diagnosis of d u o d e n a l i n v o l v e m e n t i n systemic mastocytosis. (Abstract# G0969) K Murase, BR Hewlett, H Oda, S Kohno and RH Riddell. Hamilton, Canada and Nagasaki, Japan The d e v e l o p m e n t of " v i r t u a l endoscopy" b y t r a n s a b d o m i n a l u l t r a s o n o g r a p h y . (Abstract# G1382) N Yamashita, J Hata, K Haruma, S A0ki, S Yoshida, H Kusunoki, M Hananoki, E Okamoto, S Tanaka, M Yoshihara, K Sumii and G Kajiyama. Hiroshima, Japan Correlative a n a t o m y c o m p a r i n g g a s t r o d u o d e n a l endoscopic u l t r a s o n o g r a p h y a n d t h e digitalized Visible H u m a n Project. (Abstract# GU32) IS Sandhu, JC Deutsch, VM Spitzer and SP Lawrence. Denver, CO Endoscopic u l t r a s o u n d - g u i d e d fine n e e d l e a s p i r a t i o n biopsy i n the diagnosis of u p p e r g a s t r o i n t e s t i n a l s u b m u c o s a l t u m o r s . (Abstract# G0900) M Matsui, H Goto, Y Niwa, T Arisawa, Y Hirooka, H Kameyama, S Hayakawa, N Nomura, T Hosoi, M Shinkai, S Kojima and T Hayakawa. Nagoya, Japan

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Balloon d i l a t i o n for b e n i g n p y l o r i c stenosis: long t e r m follow-up. (Abstract# G1278) AV Trifan, G Balan, M Cretu, CAnton, GO Stanciu, G Malgarinos and C Stanciu. Iasi, Romania Is d e l a y e d gastric e m p t y i n g associated w i t h i n c r e a s e d gastric or i n t e s t i n a l p e r m e a b i l i t y ? (Abstract# G1329) H Vogelsang, A Holz~ipfel, M Gmeiner, H Bergmann and G Stacher. Vienna, Austria Ascorbic acid a n d total v i t a m i n C c o n c e n t r a t i o n s i n p l a s m a , gastric juice, a n d g a s t r o i n t e s t i n a l m u c o s a i n l y m p h o c y t i c gastritis. (Abstract# G0600) M Hayat, S Everett, K White, I Drake and S O'Mahony. Leeds, United Kingdom The effects of H. pylori e r a d i c a t i o n o n the n a t u r a l h i s t o r y of l y m p h o c y t i c gastritis. (Abstract# G0601) M Hayat, DS Arora, MF Dixon and S O'Mahony. Leeds, United Kingdom Th effects of l i g h t / d a r k r e v e r s a l o n the c i r c a d i a n r h y t h m of a l c i a n b l u e b i n d i n g (mucus secretion) i n fasted r a t stomach. (Abstract# G1261) MS Taylor, SD Neeleman, KR Larsen and MT Dayton. Salt Lake City, UT Clinical c h a r a c t e r i s t i c s of p a t i e n t s with Helleobaeter pylori n e g a t i v e d u o d e n a l ulcers i n Korea. (Abstract# G0668) BG Jung, YC Lee, YM Moon, JK Kang and IS Park. Seoul, Korea C h r o n i c b r o n c h i t i s a n d p e p t i c u l c e r disease: coexisting b u t m u t u a l l y i n d e p e n d e n t conditions. (Abstract# Gl110) S Rosenstock, T J~rgensen, LP Andersen and O Bonnevie. Copenhagen, Denmark ESOPHAGEAL, GASTRIC, AND DUODENAL DISORDERS - - DYSPEPSIA Abnormal and normal electrogastrograms in p a t i e n t s w i t h f u n c t i o n a l dyspepsia. (Abstract# G0739) KL Koch, E Muth, S Bingaman and RM Stern. Hershey, PA and Pensacola, FL Effect of e r y t h r o m y c i n o n g a s t r i c e m p t y i n g a n d mealr e l a t e d s y m p t o m s i n f u n c t i o n a l dyspepsia. (Abstract# G0746) G Koek, J Tack, B Geypens, Y Gho0s and J Janssens. Leuven, Belgium Cisapride for t r e a t m e n t of n o n - u l c e r dyspepsia: a metaa n a l y s i s of r a n d o m i z e d c o n t r o l l e d trials. (Abstract# G1322) SV van Zanten, M Jones and NJ Talley. Halifax, Canada and Penrith, Australia Cisapride i m p r o v e s p o s t p r a n d i a l s y m p t o m s a n d gastric myoelectric activity i n f u n c t i o n a l dyspepsia. (Abstract# G0363) JDZ Chen, MY Ke, XM Lin, ZF Wang, M Zhang, M Mellow and WC Orr. Oklahoma City, OK C o n t r i b u t i o n of H. pylorl to d y s p e p s i a a n d antisecretory m e d i c a t i o n u s a g e i n a g e n e r a l p o p u l a t i o n . (Abstract# G0907) KEL McCall, C Morrison and M Woodward. Glasgow, Scotland The i n f l u e n c e of dyspepsia, Helieobacterpylorl s t a t u s a n d i r r i t a b l e bowel s y n d r o m e o n q u a l i t y of life i n the c o m m u n i t y . (Abstract# G0945) P Moayyedi, D Braunholtz, P Atha, AC Dowell, S Mason and ATR Axon. Leeds, United Kingdom

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Helicobacterpylo~, s y m p t o m s e v e r i t y a n d pathophysiological m e c h a n i s m s i n f u n c t i o n a l dyspepsia. (Abstract# G1231) J Tack, H Piessevaux, B C0ulie, P Caenepeel and J Janssens. Leuven, Belgium S y m p t o m p a t t e r n a n d gastric e m p t y i n g r a t e assessed b y the octanoic acid b r e a t h test i n f u n c t i o n a l dyspepsia. (Abstract# G1233) J Tack, H Piessevaux, B Coulie, B Geypens, P Caenepeel, Y Ghoos and J Janssens. Leuven, Belgium Role of visceral h y p e r s e n s i t i v i t y i n p a t i e n t s w i t h f u n c t i o n a l dyspepsia. (Abstract# G1232) J Tack, H Piessevaux, B Coulie, P Caenepeel and J Janssens. Leuven, Belgium A polymeric acid s e n s o r capable of m e a s u r i n g the severity of h e a r t b u r n . (Abstract# G1230) J Tack, G Vantrappen~ G Huybrechts, R Vos, J Janssens and R Van Overstraeten. Leuven, Belgium A systematic overview of the use of d i a r y cards, q u a l i t y of life q u e s t i o n n a i r e s a n d p s y c h o m e t r i c tests i n the t r e a t m e n t trials of Helieobacterpylori positive a n d negative n o n - u l c e r dyspepsia. (Abstract# GU31) GS Sandha, SJOV van Zanten and RH Hunt. Halifax and Hamilton, Canada T r e a t m e n t of Helieobaeterpylori does n o t i m p r o v e symptoms of f u n c t i o n a l dyspepsia. (Abstract# G0747) HR Koelz, R Arnold, M Stolte, AL Blum and the FROSCH study group. Zfirich and Lausanne, Switzerland; Marburg and Bayreuth, Germay The cost-effectiveness of d i a g n o s t i c t e s t i n g strategies for H. pyloriin p a t i e n t s with dyspepsia. (Abstract# G1006) J Ofman, D Rhew, B Kan and A Soll. Los Angeles, CA The effectiveness of endoscopy i n t h e m a n a g e m e n t of dyspepsia: a q u a l i t a t i v e systematic review. (Abstract# G0128) J Ofman and L Rabeneck. Houston, TX Are dyspeptic s y m p t o m s associated w i t h Helicobacter pylori cagA-positive infection i n the g e n e r a l p o p u l a t i o n ? (Abstract# G1074) S Pretolani, F Miglio, L Baldini, F Bonvicini, V Arienti, N Figura, ML Stefanelli, G Giulianelli, C Cecchetti, GC Ghironzi, M Polini, A Gasbarrini and G Gasbarrini. Bologna, Siena and Rome, Italy; San Marino C o m b i n e d e m p i r i c t r e a t m e n t a n d specific H. pylori s c r e e n i n g a n d t r e a t m e n t decrease t h e cost of e v a l u a t i n g epigastric a b d o m i n a l p a i n . (Abstract# G1018) AD Olson and D Deutsch. Ann Arbor, MI and Rockford, IL H y p e r s e n s i t i v i t y to lipids i n f u n c t i o n a l dyspepsia: gastric or i n t e s t i n a l ? (Abstract# G0351) A Castro, F Mearin and J-R Malagelada. Barcelona, Spain

DDW Poster of Distinction: I n f l u e n c e of r e p e a t e d phasic d i s t e n s i o n o n gastric m e c h a n o s e n s o r y f u n c t i o n i n subjects (non-patients) with a n d w i t h o u t f u n c t i o n a l dyspepsia. (Abstract# G0618) G Holtmann, J Neufang-Hfiber, H Goebell and NJ Tailey. Essen, Germany and Sydney, Australia Cardioesophageal reflexes: a n i n v a s i v e h u m a n study. (Abstract# G0865) LJK Makk, A Joseph, C Prince, M Leesar and RA Wright. Louisville, KY

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P a t i e n t s w i t h f u n c t i o n a l d y s p e p s i a r e s p o n d i n g to o m e p r a z o l e h a v e a c h a r a c t e r i s t i c reflux p a t t e r n . (Abstract# G0487) PG Farup, 0 Hovde, R Torp and S Wetterhus. Gjcvik, Norway C o p i n g b e h a v i o u r as a r i s k factor of f u n c t i o n a l dyspepsia. (Abstract# G0367) C Cheng, WM Hui, KC Lai and SK Lain. Hong Kong, China Do d y s p e p s i a s u b g r o u p s p r e d i c t r e s p o n s e to t r e a t m e n t i n f u n c t i o n a l dyspepsia? (Abstract# G0630) S Howell, NJ Talley and D Cairns. Sydney, Australia Do s y m p t o m s or psychological factors s u s t a i n healthcare s e e k i n g a m o n g s t p a t i e n t s with f u n c t i o n a l dyspepsia? (Abstract# G3165) S Howell and NJ Talley. Sydney, Australia R a n d o m i z e d c o n t r o l l e d t r i a l of omeprazole or e n d o s c o p y i n p a t i e n t s w i t h p e r s i s t e n t dyspepsia; a costeffectiveness analysis. (Abstract# G0785) RJF Laheij, JL Severens, EH van de Lisdonk, ALM Verbeek and JBMJ Jansen. Nijmegen, The Netherlands Is acid s u p p r e s s i o n efficacious i n n o n - u l c e r dyspepsia? A double-blind, randomized, controlled trial with omeprazole. (Abstract# G1248) NJ Talley, V Meineche-Schmidt, P Par~, M Duckworth, P R~iis~inen,A Pap, H Kordecki, V Schmid, P Jerndal, B Hermenius and O Junghard. Penrith, Australia

W E D N E S D A Y , MAY 20, 1998 Acute stress e n h a n c e s i n t e s t i n a l p e r m e a b i l i t y to i n t a c t p r o t e i n i n R o m a n Low Avoidance rats, b u t n o t i n R o m a n High Avoidance rats, b y a c h o l i n e r g i c m e c h a n i s m . (Abstract# G1434) FB Bijlsma, PR Saunders, F Driscoll, JM Koolhaas, JAJM Taminiau, MH Perdue and JA Groot. Amsterdam and Groningen, The Netherlands; Hamilton, Canada and Ziirich, Switzerland R e g u l a t i o n of colonic chloride t r a n s p o r t b y bile acids. (Abstract# G1744) J Venkatasubramanian, M Carlos, SG Nataraja, S Skaluba and MC Rao. Chicago, IL S e g m e n t a l differences i n the r e g u l a t i o n of colonic chloride t r a n s p o r t b y c a l c i u m m e d i a t o r s . (Abstract# G1745) J Venkatasubramanian, N Neelakantam, S Skaluba, D Vidyasagar and MC Rao. Chicago, IL P e r i p h e r a l c o r t i c o t r o p i n - r e l e a s i n g h o r m o n e increases colonic p e r m e a b i l i t y a n d ionic s e c r e t i o n t h r o u g h n i c o t i n i c p a t h w a y s a n d m a s t cells. (Abstract# G1684) J Santos, PR Saunders, D Yates, M Benjamin and MH Perdue. Hamilton, Canada H e r e g u l i n i n h i b i t s c a l c i u m - d e p e n d e n t chloride secretion: a role for ErbB2 a n d ErbB3. (Abstract# G1573) SJ Keely and KE Barrett, San Diego, CA

DDW Poster of Distinction: I N T E S T I N A L DISORDERS - - INTESTINAL T R A N S P O R T II

DDW Poster of Distinction: NHE-1 a n d NHE-2 Na/H e x c h a n g e r isoforms affect i n t r a c e l l u l a r p H g r a d i e n t s i n colonic epithelial cells (HT29-C1). (Abstract# G1522) T Gonda, D Maouyo, S Rees and MH Montrose. Baltimore, MD

DDW Poster of Distinction: Ileal b r u s h b o r d e r a c t i n - b i n d i n g p r o t e i n villin associates w i t h t h e b r u s h b o r d e r s o d i u m - h y d r o g e n exchanger, NHE3. (Abstract# G1579) S Khurana, C-M Tse, J Teng and M Don0witz. Baltimore, MD

DDW Poster of Distinction: Tissue-specific, d i f f e r e n t i a l a n d p r e t r a n s l a t i o n a l r e g u l a t i o n of Na-H e x c h a n g e isoforms b y aldosterone i n r a t colon. (Abstract# G1436) HJ Binder, M Ikuma and VM Rajendran. New Haven, CT Differential r e g u l a t i o n of NHE3 expression i n CaCo-2 cells b y PKCa. (Abstract# G1420) WA Alrefai, B Scaglione-Sewell, S Tyagi, L Wartman, TA Brasitus, K Ramaswamy and PK Dudeja. Chicago, IL S u b c h r o n i c m i l d acoustic stress e n h a n c e s the in vitro s m a l l i n t e s t i n a l p e r m e a b i l i t y to i n t a c t p r o t e i n i n r a t s b y i n c r e a s e d endocytic t r a n s p o r t . (Abstract# G1435) PB Bijlsma, MTM van Raaij, CJG D0bbe, A Timmerman, AJ Kiliaan, JAJM Taminiau and JA Groot. Amsterdam and Bilthoven, The Netherlands

Colonic epithelial ErbB2 receptors: a possible role i n diversification of i n h i b i t o r y s i g n a l i n g via the EGF receptor. (Abstract# G1572) SJ Keely, MJ Halverson and KE Barrett. San Diego, CA SCFAs p r e v e n t a n d r e v e r s e cGMP (ST t o x i n ) - i n d u c e d colonic CI" secretion. (Abstract# G1463) AN Charney, RW Egnor and RA Giannella. New York, NY and Cincinnati, OH S t i m u l a t i o n of i n t e s t i n a l chloride s e c r e t i o n b y a p r o t e a s e - a c t i v a t e d receptor-2 a c t i v a t i n g peptide. (Abstract# G1750) N Vergnolle, WK MacNaughton, JL Wallace and MD Hollenberg. Calgary, Canada I n t e s t i n a l g u a n y l i n is b o t h a l u m o n e a n d a h o r m o n a l p e p t i d e i n rats. (Abstract# G1631) F Moro, F Levenez, H Guignard, JA Chayvialle, AS Giraud and JC Cuber. Lyon and J0uy-en-J0sas, France and Melbourne, Australia I d e n t i f i c a t i o n of two f u n c t i o n a l l y d i s t i n c t a n i o n exchangers i n r a t p r o x i m a l d u o d e n u m . (Abstract# G1589) A Kretz, M Gregor and U Seidler. Tiibingen, Germany A l t e r a t i o n s i n small i n t e s t i n a l m u c o s a l versus smooth muscle f u n c t i o n i n d i a b e t i c h y p e r g l y c e m i a i n rats. (Abstract# G1621) E Mendez, J Nealon, V Pifieiro-Carrero, S Solomon and T Shea-Donohue. Bethesda, MD Crosstalk b e t w e e n apical H,K-ATPase a n d b a s o l a t e r a l K c h a n n e l regulates i n t r a c e l l u l a r (pHi) i n r a t distal colon. (Abstract# G1550) M Ikuma, HJ Binder and JP Geibel. New Haven, CT G e n i s t e i n i n h i b i t s cAMP-dependent C1 secretion a n d Na/K/2CI c o t r a n s p o r t via a t y r o s i n e k i n a s e i n d e p e n d e n t - m e c h a n i s m . (Abstract# G1698) JK Sicklick, EC Mun, I Hassan, JC Song and JB Matthews. Boston, MA

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20, 1998

Action of n o n - p e p t i d e s u b s t a n c e P a n t a g o n i s t , CP 96,345, o n c h o l e r a t o x i n a n d E. c o l i e n t e r o t o x i n - i n d u c e d secretion. (Abstract# G1736) JL Turvill, P Connor and MJG Farthing. London, United Kingdom

Differential effects of u r i d i n e t r i p h o s p h a t e o n i n t e s t i n a l chloride s e c r e t i o n d e p e n d i n g o n side of addition: i m p l i c a t i o n s for cystic fibrosis t h e r a p y . (Abstract# G1701) JE Smitham and KE Barrett. San Diego, CA

5-HT3 a n t a g o n i s t , g r a n i s e t r o n , d i r e c t l y i n h i b i t s cholera t o x i n - i n d u c e d 5-HT release from e n t e r o c h r o m a f f i n cells. (Abstract# G1735) JL Turvill, P Connor and MJG Farthing. London, United Kingdom

R e g u l a t i o n of apical m e m b r a n e Na÷/H÷ e x c h a n g e r s NHE2 a n d NHE3 i n a n i n t e s t i n a l e p i t h e l i a l cell line C2/bbe. (Abstract# G1617) RL McSwine, MW Musch, C Bookstein, Y Xie, M Rao and EB Chang. Chicago, IL

G e n i s t e i n a u g m e n t s p r o s t a g l a n d i n - i n d u c e d recovery of b a r r i e r f u n c t i o n i n i s c h e m i c - i n j u r e d p r o c i n e ileum. (Abstract# G1438) AT Blikslager, MC Roberts and RA Argenzio. Chapel Hill, NC

Effect of corticosteroids o n Na-glucose c o t r a n s p o r t i n h i b i t i o n i n the c h r o n i c a l l y i n f l a m e d r a b b i t ileum. (Abstract# G1471) S Coon, AB West and U Sundaram. Columbus, OH and Galveston, TX

Cystic fibrosis p a t i e n t s h a v e i m p a i r e d d u o d e n a l m u c o s a l t r a n s p o r t . (Abstract# G1655) V Pratha, DL Hogan, B Martensson and JI Isenberg. San Diego, CA

Effect of Saechmeomyces b o u l ~ f l i o n Ca2÷-mediated secretion i n T84 cells. (Abstract# G1477) D Czerucka and P Rampal. Nice, France

M u r i n e colonic e p i t h e l i a l i o n t r a n s p o r t is a l t e r e d i n r e s p o n s e to t h e b a c t e r i a l s u p e r a n t i g e n s Staphylococcus a u r e u s e n t e r o t o x i n B or Yersinia p s e u d o t u b e r c u l o s i s mitogen. (Abstract# G1602) J Lu, MA Benjamin, T Takeda and DM McKAy. Hamilton, Canada and Tokyo, Japan

Effect of local a d m i n i s t r a t i o n of a n o n - p e p t i d e NK3 r e c e p t o r antagonist, SR 142801, o n Clostridium d/DTcile~induced d i a r r h e a i n g u i n e a pigs. (Abstract# G1725) V Theod0rou, P Marche, G C0rthier, X Edmonds-Alt, J Fioram0nti and L Bueno. Toulouse, J0uy and Montpellier, France

Apical Na ÷ c h a n n e l a n d b a s o l a t e r a l Na÷,K÷-ATPase e x p r e s s i o n i n distal colon i n u l c e r a t i v e colitis. (Abstract# G1528) ER Greig, JC McHale, RP B0ot-Handford, MN Marsh, V Mani and GI Sandle. Salford and Manchester, United Kingdom

C o m p a r a t i v e a n t i s e c r e t o r y effect of l o p e r a m i d e s o m a t o s t a t i n a n d the sigma l i g a n d i g m e s i n e o n IL-I~i n d u c e d colonic h y p e r s e c r e t i o n i n rats. (Abstract# G1724) V Theodor0u, M Chovet, J Fioramonti and L Bueno. Toulouse and Fresnes, France

T u m o r necrosis factor-a r e d u c e s t i g h t j u n c t i o n complexity i n HT-29/B6 colonic monolayers. (Abstract# G1690) H Schmitz, H Bode, K Detjen, P Scholz, CJ Bentzel, M Fromm and JD Schulzke. Berlin, Germany and Greenville, NC

5-HT activates a n e n t e r i c n e u r a l reflex m o d u l a t i n g t r a n s p o r t i n r e s p o n s e to m u c o s a l s t r o k i n g i n m a n . (Abstract# G1418) FC Albuquerque, Jr, MC Stoner and JM Kellum. Richmond, VA

Exotoxins from a p a t h o g e n i c A e r o m o n a s s t r a i n i n d u c e electrolyte s e c r e t i o n i n colon e p i t h e l i a l cells (HT-29/B6). (Abstract# G1495) HJ Epple, M Fromm, EO Riecken and JD Schulzke. Berlin, Germany I n h i b i t i o n of cyclooxygenase p r e v e n t s the s t i m u l a t i o n of i o n s e c r e t i o n b y l i p o p o l y s a c c h a r i d e i n the h u m a n distal colon. (Abstract# G1452) S Biihner, H Bode, H Schmitz, JD Schulzke and H Lochs. Berlin, G e r m a n y H u m a n a n d r a t colonic m u c o s a as t a r g e t s for sorbin. (Abstract# G1499) B Eto, M Boisset, B Griesmar and J-F Desjeux. Paris, France

Interleukin-2 modulates ion transport and cellular p r o l i f e r a t i o n i n a h u m a n small i n t e s t i n a l cell line. (Abstract# G1645) E O'Loughlin, R Noltorp, C Koina, R Clancy, R Batey and G Pang. Newcastle, Australia Cross-talk b e t w e e n c a l c i u m a n d cyclic-AMP s i g n a l l i n g at serosal p o t a s s i u m c h a n n e l s i n h u m a n colonic mucosae. (Abstract# G1764) DC Winter, B McNamara, GC O'Sullivan and BJ Harvey. Cork, Ireland Glucose t r a n s p o r t a n d SGLT-1 e x p r e s s i o n i n a model of s p o n t a n e o u s type I diabetes. (Abstract# G1485) L D0negan, BM Chung, JA Hardin and DG Gall. Calgary, Canada

The role of i n t r a c e l l u l a r c a l c i u m i n cholera toxinm e d i a t e d chloride s e c r e t i o n i n colonic crypts. (Abstract# G1659) AM Qureshi, M Ikuma, EB Rodas, GR Ortega and JP Geibel. New Haven, CT

G l u t a m i n e i n h i b i t i o n of phorbol-12,13-dibutyratei n d u c e d m a c r o m o l e c u l a r h y p e r p e r m e a b i l i t y i n HT29c1.19A h u m a n i n t e s t i n a l cells is d e p e n d e n t o n apical exposure. (Abstract# G1590) L Kutznetsova, PB Bijlsma, PAM van Leeuwen, JA Groot and APJ Houdijk. Amsterdam, The Netherlands

Effects of c h o l e r a t o x i n o n chloride t r a n s p o r t m e c h a n i s m s i n t h e b a s o l a t e r a l m e m b r a n e of colonic crypts. (Abstract# G1658) AM Qureshi, GR Ortega, EB Rodas and JP Geibel. New Haven, CT

Basal a n d s t i m u l a t e d electrical t r a n s p o r t characteristics of the m u r i n e p r o x i m a l colon. (Abstract# G1601) AL Lopez, FR H0maidan, LM Zhao and R Burakoff. Mine01a and Stony Brook, NY

April 1998

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A G A P O S T E R S E S S I O N - - W E D N E S D A Y i M A Y 20, 1998 I N T E S T I N A L DISORDERS - - SPLANCHNIC C I R C U L A T I O N AND DISEASE E n d o t h e l i n - 1 causes P - s e l e c t i n - d e p e n d e n t leukocyte r o l l i n g a n d a d h e s i o n w i t h i n the r a t m e s e n t e r i c microvessels. (Abstract# G1685) MJ Sanz, B Johnston and P Kubes. Calgary, Canada P a r a d o x i c a l c h a n g e s i n s p l a n c h n i c blood flow after a r g i n a s e i n f u s i o n i n t h e rat. (Abstract# G1657) HA Prins, APJ Houdijk, AA van Lambalgen, S Meijer, T Teerlink and PAM van Leeuwen. Amsterdam, The Netherlands Anti-P s e l e c t i n m o n o c l o n a l a n t i b o d y protects a g a i n s t r e t i c u l o e n d o t h e l i a l system d y s f u n c t i o n following h e p a t i c i s c h e m i a / r e p e r f u s i o n . (Abstract# G1679) N Sakamoto, ML Brengman, K Maemura, ZL Sun, M Ozaki, GB Bulkley and AS Klein. Baltimore, MD The role of s u b s t a n c e P a n d n e u r o k i n i n receptors i n a c i d - i n d u c e d h y p e r e m i a i n the o p o s s u m esophagus. (Abstract# G1504) MJ Feldman, GP Morris and WG Paterson. Kingston, Canada C o m p a r i s o n of e n d o t h e l i n vasomotor actions o n a r t e r i o l e s a n d v e n u l e s i n the i n t e s t i n a l m i c r o c i r c u l a t i o n . (Abstract# G1606) PH MacDonald and S Vanner. Kingston, Canada Hepatic r e t i c u l o e n d o t h e l i a l k i l l i n g of c i r c u l a t i n g E. coli is d e p e n d e n t u p o n p e r i p h e r a l n e u t r o p h i l s via Mac-1 (CDIIb/CD18). (Abstract# G1447) M Brengman, D Wang, KB Wilkins, N Sakamoto, T Arai, AS Klein and GB Bulkley. Baltimore, MD

I n t e s t i n a l p e r m e a b i l i t y i n critical illness a n d acute liver failure: the r e l a t i o n s h i p w i t h s e v e r i t y of illness, s p l a n c h n i c i s c h e m i a a n d survival. (Abstract# G1513) SM Gabe, M Patel, GK Grimble, R Williams, I Bjarnason and DBA Silk. London, United Kingdom Clinical use of a n e w n e a r - i n f r a r e d spectroscopic system i n a b d o m i n a l s u r g e r y - a d i a g n o s t i c aid i n nonocclusive disease. (Abstract# G1689) O Scheufler, J Schmidt, VD Mohr, F Steinberg, R Lampert, L Brandt and H Zirngibl. Witten-Herdecke and Essen, Germany Roles of i n d u c i b l e n i t r i c oxide s y n t h a s e a n d cyclooxygenase-2 i n the h y p e r a e m i a of the i n f l a m e d gallbladder. (Abstract# G1642) B Nilsson, S Friman and J Svanvik. GSteborg and LinkSping, Sweden P o s t p r a n d i a l s p l a n c h n i c h e m o d y n a m i c s as activity i n d e x i n i n f l a m m a t o r y bowel disease: a prospective a n d c o n t r o l l e d follow-up study. (Abstract# G1603) D Ludwig, A Brfining, S Wiener, G Jantschek and EF Stange. L~ibeck, Germany Is s u p e r i o r m e s e n t e r i c a r t e r y flow i n c r e a s e d i n p a t i e n t s with e a r l y d u m p i n g s y n d r o m e ? (Abstract# G1743) J Vecht, JA van Oostayen, CBHW Lamers and AAM Masclee. Leiden, The Netherlands V a r i a t i o n i n s y n c h r o n o u s t o n o m e t r i c m e a s u r e m e n t of gastric i n t r a m u c o s a l pCO 2 i n the c r i t i c a l l y ill. (Abstract# G1445) NH Boyle, PC Roberts, D Manifold, A McLuckie, RC Mason and RJ Beale. London, United Kingdom

DDW Poster of Distinction:

E n d o t o x e m i a depresses h e p a t i c r e t i c u l o e n d o t h e l i a l f u n c t i o n a n d c o n s e q u e n t l y r e d i s t r i b u t e s the t r a p p i n g of c i r c u l a t i n g b a c t e r i a to the lung. (Abstract# G1446) M Brengman, D Wang, E Smith, AS Klein and GB Bulkley. Baltimore, MD

Molecular m e c h a n i s m s of n e u t r o p h i l - e n d o t h e l i a l cell i n t e r a c t i o n s i n d u c e d b y r e d o x i m b a l a n c e . (Abstract# G1585) S Kokura, RE Wolf, DN Granger and TY Aw. Shreveport, LA

X a n t h i n e oxidase, r e a c t i v e oxidants a n d n e u t r o p h i l s i n h e p a t i c i n j u r y following h e m o r r h a g i c shock/resuscitation. (Abstract# G1768) Y Yamakawa, M Takano, KB Wilkins, N Tien, M Patel and GB Bulldey. Baltimore, MD

B r a d y k i n i n m e d i a t e s P-selectin e x p r e s s i o n i n r a t g a s t r o i n t e s t i n a l m i c r o v a s c u l a t u r e . (Abstract# G1675) Z R0zsa, J Russell, J Salter and DN Granger. Shreveport, LA I n c r e a s e d p l a s m a f i b r i n o l y t i c activity i n h u m a n g a s t r o i n t e s t i n a l angiodysplasia. (Abstract# G1564) F Junquera, E Saperas, A Angl~s, J Monasterio and JR Malagelada. Barcelona, Spain

P r o g n o s t i c v a l u e of gastric t o n o m e t r y i n perforationi n d u c e d p e r i t o n i t i s a n d laparoscopic versus open r e p a i r i n a p i g model. (Abstract# G1709) T Strate, C Bloechle, A Emmermann, M Wolf, C Z0rnig and CE Broelsch. Hamburg, Germany

DDW Poster of Distinction:

T o w a r d s a d i a g n o s t i c test of a b d o m i n a l s y m p a t h e t i c d y s f u n c t i o n . (Abstract# G1509) J Fujimura, M Camilleri, PA Low, V N0vak, P Novak and TL Opfer-Gehrking. Rochester, MN

Non-invasive d e t e c t i o n of n o r m a l a n d ischemic bowel i~ v/vo u s i n g a SQUID. (Abstract# G1591) JK Ladipo, LA Bradshaw, SS Hegde, S Halter, SA Seidel, JP Wiksw0, Jr and WO Richards. Nashville, TN

M o d u l a t i o n of v a s c u l a r n o r e p i n e p h r i n e r e s p o n s i v e n e s s by potassium channels in normal and portal h y p e r t e n s i v e rats. (Abstract# G1557) Z Jiao, MS Taylor and JN Benoit. Mobile, AL

Lisofylline ameliorates ileal ischemia/reperfusioni n d u c e d mucosal b a r r i e r d y s f u n c t i o n i n rats. (Abstract# G1758) S Wattanasirichaigoon, MJ Menconi, RL Delude and MP Fink. Boston, MA

Interleukin-1 receptor antagonist prevents h y p o p e r f u s i o n of i n t e s t i n a l m u c o s a i n septic shock. (Abstract# G1583) K Klemm, RF Lodato and FG Moody. Houston, TX Effect of a n h e p a t i c s i n u s o i d a l e n d o t h e l i a l cell f r a c t i o n o n Kupffer cell a n t i g e n p r e s e n t a t i o n . (Abstract# G1608) K Maemura, ZL Sun, N Sakamote, M Ozaki, GB Bulkley and AS Klein. Baltimore, MD

R y a n o d i n e or ischemic p r e c o n d i t i o n i n g a t t e n u a t e postischemic leukocyte a d h e s i o n a n d m i c r o v a s c u l a r b a r r i e r d i s r u p t i o n i n r a t m e s e n t e r y . (Abstract# G1551) T Ishida, K Yarimizu, DC Gute and RJ Korthuis. Shreveport, LA

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Role of T l y m p h o c y t e s i n h e p a t i c leukostasis a n d hypoxic stress i n d u c e d b y gut i s c h e m i a / r e p e r f u s i o n i n mice. (Abstract# G1545) Y Horie, R Wolf, RP Chervenak, SR Jennings and DN Granger. Shreveport, LA Chronic mesenteric ischemia reduces disaccharidase activity w i t h o u t affecting morphology. (Abstract# G1628) WK Moon, SC Wang, SM S10nim, KCP Li, CK Zarins, GM Gray and RL Dalman. Stanford, CA I m p o r t a n c e of c o m p l e m e n t a c t i v a t i o n a n d mucosal m a s t cell d e g r a n u l a t i o n i n the p a t h o g e n e s i s of r a p i d i n t e s t i n a l i s c h e m i a - r e p e r f u s i o n i n j u r y i n rats. (Abstract# G1581) T Kimura, A Andoh, T Saotome, M Fukuda, Y Fujiyama and T Bamba. Otsu, Japan Mucosal p r o t e c t i o n w i t h exaggerated i n f l a m m a t i o n after r e p e a t e d i n t e s t i n a l i s c h e m i a - r e p e r f u s i o n i n rats. (Abstract# G1626) T Miner, H Tavaf-Motamen, CM Gallagher, WC Conner and T Shea-Donohue. Washington, DC and Bethesda, MD I n c r e a s e d i n f l a m m a t o r y r e s p o n s e to ischemiar e p e r f u s i o n i n diabetes: role of l i p i d m e d i a t o r s a n d a d h e s i o n molecule expression. (Abstract# G1681) A Salas, J Pan~s, JI Elizalde, M Casadevall, DN Granger and JM Pique. Barcelona, Spain and Shreveport, LA T r e a t m e n t w i t h NO d o n o r s b l u n t s d i a b e t e s - i n d u c e d i n c r e a s e i n l e u k o c y t e r e c r u i t m e n t after s p l a n c h n i c ischemia]reperfusion, Role of P-selectin. (Abstract# G1682) A Salas, J Pan~s, JI Elizalde, M Casadevall, DN Granger and JM Pique. Barcelona, Spain and Shreveport, LA Diabetes exacerbates free r a d i c a l p r o d u c t i o n i n r e s p o n s e to s p l a c h n i c ischemia/reperfusion. M e c h a n i s m s a n d c e l l u l a r origin. (Abstract# G1680) A Salas, J Pan~s, JI Elizalde, M Casadevall, DN Granger and JM Pique. Barcelona, Spain and Shreveport, LA Role of gastric acid s e c r e t i o n i n the f o r m a t i o n of gastric lesions i n d u c e d b y ischemia-reperfusion. (Abstract# G1451) T Brzozowski, S Kwieciefi, Z ~liwowski, R Pajdo, D Drozdowicz, PC Konturek and SJ Konturek. Krakow, Poland and Erlangen, Germany The effect of FR167653 o n small bowel ischemiar e p e r f u s i o n i n j u r y i n dogs. (Abstract# G1721) I Takeyoshi, K Iwanami, Y Kawashima, K Kawada, M Aiba, J Kobayashi, T Ohya, K Kawashima, T Yamada, S Kawate, Y Nakasone, K Arai, T Ogawa, S Ohwada, Y Iino, K Matsumoto and Y Morishita. Maebashi and Kawasaki, Japan S e n s i t i z a t i o n of r a t j e j u n u m to 5 - h y d r o x y t r y p t a m i n e after m e s e n t e r i c i s c h e m i a / r e p e r f u s i o n . (Abstract# G1670) MD Rogers, J Hardcastle, PT Hardcastle and D Grundy. Sheffield, United Kingdom U t i l i t y of s e r u m m a r k e r s i n p r e d i c t i n g s u r v i v a l i n acute i n t e s t i n a l ischemia. (Abstract# G1517) GR Gambla and W Joyce. Hershey, PA and Farmington Hills, MI E n d o g e n o u s i n t e r l e u k i n - 1 0 does n o t m o d u l a t e local or systemic i n j u r y i n a m u r i n e model of i s c h e m i a a n d r e p e r f u s i o n . (Abstract# G1587) TD Kou, K Umanskiy, KA Miller, A Stallion, AD Levine and DL Dudgeon. Cleveland, OH

GASTROENTEROLOGY Vol. 114~ No. 4

PANCREATIC DISORDERS - - CHRONIC PANCREATITIS AND PANCREATIC CANCER: CLINICAL STUDIES Lymphocyte subsets a n d cellular i m m u n i t y i n p a t i e n t s w i t h c h r o n i c p a n c r e a t i t i s . (Abstract# G1985) J Ockenga, A Kemper, R Jac0bs and MP Manns. Hannover, Germany C o m m o n bile d u c t stenosis i n c h r o n i c p a n c r e a t i t i s : is endoscopic b i l i a r y d r a i n a g e u p to date? (Abstract# G1856) M Farnbacher, HT Schneider, S Mfihld0rfer, J H0chberger, C Ell and EG Hahn. Erlangen-Nuremberg, Germany H e r e d i t a r y chronic p a n c r e a t i t i s : h e t e r o g e n e i t y of m u t a t i o n s of the gene of cationic t r y p s i n o g e n . (Abstract# G1857) C F~rec, O Raguenes, B Mercier, JD Bignon, T Georgelin, F Soulard and L Le Bodic. Nantes and Brest, France Differential n e u r o a x i a l blockade is useful i n d e t e r m i n i n g the cause of c h r o n i c a b d o m i n a l p a i n i n p a t i e n t s with c h r o n i c p a n c r e a t i t i s . (Abstract# G1827) DL ConweU, JJ Vargo, TE Dews, RM Walsh, SF Grundfest, JA Dumot, SS Shay and G Zuccaro. Cleveland, OH Multi-center e v a l u a t i o n of endoscopic u l t r a s o u n d guided celiac plexus n e u r o l y s i s for t r e a t i n g a b d o m i n a l p a i n associated w i t h c h r o n i c p a n c r e a t i t i s . (Abstract# G1884) F Gress, D Ciaccia, S Sherman and G Lehman. Stony Brook, NY and Indianapolis, IN U s i n g endoscopic u l t r a s o u n d for p r e o p e r a t i v e s t a g i n g i n p a t i e n t s w i t h p a n c r e a t i c cancer: p r e d i c t o r s of survival. (Abstract# G1885) F Gress, J Rizz0, H Shady, D Ciaccia, D Bernstein and G Lehman. Stony Brook, NY and Indianapolis, IN A u t o n o m i c n e r v o u s f u n c t i o n i n alcohol-related c h r o n i c p a n c r e a t i t i s . (Abstract# G2009) L Rosa-e-Silva, RB Oliveira, LE Tronc0n, L Gallo, Jr and MC Foss. Ribeir~o Preto, Brazil Different m i x i n g of chyme a n d lipolytic a c t i v i t y i n p o w d e r a n d m i c r o t a b l e t f o r m u l a t i o n s of b a c t e r i a l lipase d u r i n g GI t r a n s i t explains v a r i a b l e c o r r e c t i o n of c a n i n e p a n c r e a t i c s t e a t o r r h e a . (Abstract# G1822) JP Chung, A Metzger, N Asakura, MG Sarr and EP DiMagno. Rochester, MN Is t h e 5T m u t a t i o n i n i n t r o n 8 of t h e cystic fibrosis gene associated w i t h alcoholic p a n c r e a t i t i s ? (Abstract# G1895) PS Haber, ID Norton, MD Norris, MV Apte, RC Pir01a, IC Roberts-Th0mson and JS Wilson. Sydney and Adelaide, Australia Long t e r m benefit after e x t r a c o r p o r e a l shock-wave l i t h o t r i p s y of p a n c r e a t i c duct stones i n p a t i e n t s w i t h c h r o n i c p a n c r e a t i t i s . (Abstract# G2018) HT Schneider, M Farnbacher, C SchSn, T Rabenstein, J Benninger, A May, C Ell and EG Hahn. ErlangenNuremberg, Germany E v a l u a t i o n of the 13 C-mixed t r i g l y c e r i d e b r e a t h test f o r exocrine p a n c r e a t i c insufficiency. (Abstract# G1844) JE Dominguez-Mufioz, A Leodolter, S Kaht and P Malfertheiner. Magdeburg, Germany Effects of oral p a n c r e a t i c enzyme o n g a s t r o b i l i a r y dysmotility i n c h r o n i c p a n c r e a t i t i s p a t i e n t s . (Abstract# G1972) T Mizushima, K Ochi, K Sawa, N Matsumura and H Harada. Okayama, Japan

A p r i l 1998

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P R O G R A M O F T H E A N N U A L M E E T I N G P21

A G A P O S T E R S E S S I O N - - W E D N E S D A Y , M A Y 20, 1998

N e u r o f i l a m e n t p r o t e i n is associated with p a i n a n d increased parenchymatous pressures in chronic p a n c r e a t i t i s . (Abstract# G1953) JC Limmer, WT Knoefel, JR Izbicki, C Bloechle and CE Broelsch. Hamburg, Germany I d e n t i f i c a t i o n of h e r e d i t a r y p a n c r e a t i t i s m u t a t i o n i n t h r e e West V i r g i n i a families. (Abstract# G1853) Y Elitsur, BC Chertow, RD Jewell, SN Finver and DA Primerano. Hungtinton, WV P a r a m e t r i c u l t r a s o u n d of the p a n c r e a s : changes of t e x t u r a l p a r a m e t e r s d e p e n d e n t o n clinical stages. (Abstract# G1799) JS Bleck, C Bunck, M Gebel, B Boozari, J Ockenga, PN Meier, S Wagner, C Strassburg, M Westhoff-Bleck and M Manns. La J011a, CA and Hannover, Germany

DDW Poster of Distinction: Telomerase activity for t h e p r e o p e r a t i v e diagnosis of p a n c r e a t i c cancer. (Abstract# G1915) T Iwao, E Hiyama, A Tsuchida, M Hirata, N Eguchi, T Sasaki, K Matsubara, S Yamamoto, Y Kawasaki, K Morinaka and G Kajiyama. Hiroshima, Japan

DDW Poster of Distinction: Q u a n t i t a t i v e analysis of r a s gene m u t a t i o n i n p a n c r e a t i c s e c r e t i o n s for d i a g n o s i s of p a n c r e a t i c carcinoma: c o m p a r i s o n w i t h t h r e e different assays. (Abstract# G2047) M Tada, K Tateishi, M Yamagata, H Isayama, Y Komatsu, T Kawabe, H Yoshida, Y Shiratori and M Omata. Tokyo, Japan

Elastase-1 i n feces: l y o p h i l i z a t i o n of stool samples m a y p r e v e n t false low r e s u l t s i n d i a r r h e a . (Abstract# G1860) BP Fischer, M Wehler, M MOiler, EG Hahn and HT Schneider. Erlangen-Nuremberg, Germany

P r e v a l e n c e a n d course of p a n c r e a t i c lesions i n Von H i p p e l - L i n d a u disease. (Abstract# G1897) P Hammel, V Vilgrain, P Ruszniewski, P Bernades, S Richard and the Groupe Francophone d'Etude de la Maladie de von Hippel-Lindau. Clichy and Paris, France

Type IV collagen i n p a n c r e a t i c j u i c e of p a t i e n t s with c h r o n i c p a n e r e a t i t i s . (Abstract# G1984) K Ochi, N Matsumura, T Mizushima, M Ichimura, M Yokoyama, K Sawa and H Harada. Okayama, Japan

Analysis of the prognosis of i n t r a d u c t a l p a p i l l a r y m u c i n o u s t u m o r s of t h e p a n c r e a s . (Abstract# G2079) K Yamao, K Ohashi, T Furukawa, T Nakamura, T Suzuki, S Teramoto, Y Shimizu and K Yasui. Nagoya, Japan

C o n v e n t i o n a l p a n c r e a t i c enzymes are more efficient t h a n e n t e r i c coated enzymes i n d e l i v e r i n g t r y p s i n to the d u o d e n u m of c h r o n i c p a n c r e a t i t i s patients. (Abstract# G2038) L Somogyi and PP Toskes. Gainesvflle, FL

New i m m u n o r a d i o a s s a y for p l a s m a c h r o m o g r a n i n A i n e n d o c r i n e tumors. (Abstract# G1855) K Farahat, A Meulemans, A Zay~ne, D Le Guludec, M Mignon and G Cadiot. Paris, France

E v a l u a t i o n of small i n t e s t i n a l b a c t e r i a l overgrowth i n fibrocalculous p a n c r e a t i c diabetes. (Abstract# G1789) PK Bardhan, M Kogon, AK Azad Khan, C Beglinger and N Gyr. Dhaka, Bangladesh and Basel, Switzerland A b n o r m a l i t i e s of t h e CFTR gene p r e d i s p o s e to i d i o p a t h i c c h r o n i c p a n c r e a t i t i s . (Abstract# G1826) JA Cohn, KJ Friedman, LM Silverman, PG Noone, CQ Lee, MR Knowles and PS Jowell. Durham and Chapel Hill, NC Clinical e v a l u a t i o n of fecal elastase 1 as exocrine f u n c t i o n test i n t h e diagnosis of c h r o n i c p a n c r e a t i t i s . (Abstract# G1817) HS Choi, JS Ham, DS Han, JH Son, YC Jun, OY Lee, BC Yoon, MH Lee, CS Kee and KN Park. Seoul, Korea Delayed m a x i m a l s e c r e t i n - s t i m u l a t e d p a n c r e a t i c exocrine s e c r e t i o n i n c h r o n i c p a n c r e a t i t i s . (Abstract# G1808) FR Burton and WA Knight, Jr. St Louis, MO Correlation between hepatopathy and pancreatic d i s o r d e r s i n alcoholics c h r o n i c p a n c r e a t i c disorders i n p a t i e n t s w i t h liver cirrhosis. (Abstract# G2029) M Shiozaki, Y Takeda and K Katsu. Takatsuki and Kyoto, Japan

M u c i n - p r o d u c i n g t u m o r s of the p a n c r e a s : a long t e r m follow-up s t u d y i n 22 p a t i e n t s . (Abstract# G1983) T Obara, T Fujii, S Tanno, T Izawa, N Nishino, H Ura and Y Kohgo. Asahikawa, Japan P r e o p e r a t i v e l o c a l i z a t i o n a n d diagnosis of p a n c r e a t i c a n d p e r i p a n c r e a t i c islet cell t u m o r s u s i n g endoscopic u l t r a s o u n d - g u i d e d fine n e e d l e a s p i r a t i o n : a m u l t i c e n t e r experience. (Abstract# G1824) D Ciaccia, M A1-Assi,MJ Wiersema, B Hoffman, G Lehman, S Sherman, PS Jowell and FG Gress. Indianapolis, IN; Stony Brook, NY and Charleston, SC Telomerase expression i n p a n c r e a t i c c a r c i n o m a . (Abstract# G1919) R Jesenofsky, J-M LShr, P Moiler and S Liebe. Rostock, Germany MR c h o l a n g i o p a n c r e a t o g r a p h y b y u s i n g endoscopic MRI. (Abstract# G1912) K Inui, S Nakazawa, J Yoshino, K Okushima, Y Nakamura, H Ukai, K Morita and K Yamakawa. Nagoya and Seto, Japan

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E x o c r i n e p a n c r e a t i c f u n c t i o n i n p a t i e n t s with tropical c h r o n i c p a n c r e a t i t i s . (Abstract# G2010) L Rossi, P Hildebrand, S Ketterer, C Beglinger, K Gyr, L Ali and AK Azad Khan. Basel, Switzerland and Dhaka, Bangladesh Histopathologic c o r r e l a t i o n of endoscopic u l t r a s o u n d f i n d i n g s of c h r o n i c p a n c r e a t i t i s i n h u m a n autopsies. (Abstract# G1796) MS Bhutani, J Moezzi, S Suryaprasad, N Peace, WD Brown, N G0palswamy, C Barde and R Hawes. Dayton, OH and Charleston, SC

F u n c t i o n i n g h u m a n i n s u l i n o m a s . An i m m u n o h i s t o c h e m i c a l a n a l y s i s of i n t r a c e l l u l a r i n s u l i n processing. (Abstract# G1786) C Azzoni, T D'Adda, G Tamburrano, L Sc0psi and C Bordi. Parma and Rome, Italy Diagnostic a c c u r a c y of s o m a t o s t a t i n r e c e p t o r s c i n t i g r a p h y for p r e o p e r a t i v e l o c a l i z a t i o n of digestive e n d o c r i n e tumors. (Abstract# G1862) C Flobert, E Le Stanc, J Belghiti, P Hammel, E Robin, I Madeira, P Bernades, B Bok and P Ruszniewski. Clichy, France The e x p r e s s i o n of t u m o r - r e j e c t i o n a n t i g e n '2YIAGE" genes i n p a n c r e a t i c c a r c i n o m a . (Abstract# G2037) B Simon, N Prasnika and R Arnold. Marburg, Germany

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A G A P O S T E R S E S S I O N - - W E D N E S D A Y , MAY 20, 1998 Diagnosis of p a n c r e a t i c masses: t h e role of endoscopic u l t r a s o u n d - g u i d e d biopsy. (Abstract# G2067) M Voss, P Hammel, G M01as, L Palazzo, A Dancour, P Ruszniewski and P Bernades. Clichy, France P r e o p e r a t i v e n o n - r e s e c t a b i l i t y c r i t e r i a for p a n c r e a t i c head adenocarcinoma: a practical survey among F r e n c h g a s t r o e n t e r o l o g i s t s a n d surgeons. (Abstract# G1946) P L~vy, MJ Goudet, M Zins, B Gayet, the Soci~t~ Fran~aise de Chirugie Digestive and IMM Choisy. Paris, France EGF e n h a n c e s the effect of vasoactive i n t e s t i n a l h o r m o n e i n e l e v a t i n g t h e level of t h e p a n c r e a t i c t u m o r a n t i g e n ND2. (Abstract# G1909) JJL Ho, ER FarreUy and YS Kim. San Francisco, CA

DDW Poster of Distinction: Long t e r m effect of endoscopic b a l l o o n s p h i n c t e r o p l a s t y on p a p i l l a r y f u n c t i o n e v a l u a t e d by n i t r o g l y c e r i n - s t i m u l a t e d c h o l e s c i n t i g r a p h y . (Abstract# G2163) H Matsumoto, H Asaoka, N Kawanishi and M Suzuki. Ibaraki, Japan DDW Poster of Distinction: ERCP for b i l i a r y t r a c t disease i n p r e g n a n c y . (Abstract# G2161) TC Lin and S Steinberg. Denver, CO T r a n s c y s t i c d r a i n i n g t u b e for i n t r a o p e r a t i v e l y diagnosed c o m m o n bile d u c t stones. (Abstract# G2096) B Anesten and C J6nson. Bor~s, Sweden

M u c i c a r m i n e s t a i n i n g of fine n e e d l e a s p i r a t e s of cyst f l u i d c a n d i f f e r e n t i a t e m u c i n o u s cystic n e o p l a s m from o t h e r cystic lesions of t h e p a n c r e a s . (Abstract# G2013) JK Ryu, Y-T Kim, IA Park, YB Yoon and CY Kim. Seoul, Korea

Laparoscopic bile duct stones m a n a g e m e n t i n t h e first 100 of 216 consecutive u n s e l e c t e d p a t i e n t s . (Abstract# G2190) AM Paganini, M Guerrieri, F Feliciotti, A Tamburini, R Campagnacci and E Lezoche. Ancona, Italy

P h o t o d y n a m i c t h e r a p y for i n o p e r a b l e p a n c r e a t i c c a n c e r effectively d e b u l k s t u m o u r a n d is well tolerated. (Abstract# G2077) DE Whitelaw, WR Lees, PM Ripley, A Gillams, ARW Hatfield and SG Bown. London, United Kingdom

C o m p a r i s o n of t r e a t m e n t s for h e p a t o l i t h i a s i s : h e p a t i c resection versus cholangioscopic lithotomy. (Abstract# G2189) K Otani, S Shimizu, K Chijiiwa, K Yamaguchi, S Kur0ki and M Tanaka. Fukuoka, Japan

Matrix m e t a l l o p r o t e i n a s e s i n p a n c r e a t i c cancer: effects of d i f f e r e n t i a t i o n o n a c t i v i t y in vitro a n d i n vivo. (Abstract# G2024) A Shafii, E Zervos and A Rosemurgy. Tampa, FL

Laser l i t h o t r i p s y of difficult bile d u c t stones. A fiveyear experience. (Abstract# G2141) R Jakobs, C Benz, W-R Martin, JC Arnold and J F Riemann. Ludwigshafen, Germany

The u s e f u l n e s s of delayed-phase i m a g i n g of helical CT for the e v a l u a t i o n of p a n c r e a t i c cancer. (Abstract# G2055) T Tsuda, S Sugata, K Murase and J Ikezoe. Ehime, Japan

Long t e r m e n d o b i l i a r y s t e n t p l a c e m e n t for cholangitis i n n o n a g e n a r i a n s : a n age a p p r o p r i a t e a p p r o a c h . (Abstract# G2167) DE McGuire and WF Zakko. Ft Lauderdale, FL

BILIARY DISORDERS - - T R E A T M E N T

Endoscopic a m p u l l e c t o m y for t u m o r s of t h e a m p u l l a of Vater: long t e r m follow-up result. (Abstract# G2160) SK Lee, SY Song, JB Chung, JH Lee, JK Kang, YM Moon and IS Park. Se0ul, Korea

New baby-pepillotome for p r i m a r y c a n n u l a t i o n or p r e c u t . (Abstract# G2209) H Seifert, T Wehrmann, K Binmoeller and WF Caspary. Frankfurt, Germany Effect of endoscopic p a p i l l a r y b a l l o o n d i l a t i o n for the m a n a g e m e n t of c o m m o n bile d u c t stones i n the elderly. (Abstract# G2138) F Iwata, T Miyaki, J Yamada, T Joh and M Itoh. Nagoya, Japan Bile acid d i s s o l u t i o n t h e r a p y of gallstone disease. (Abstract# G2172) M Miloshevski, V Serafn-noski, M Neshkovski, N Joksimovic and J Mishevski. Skopje, Macedonia Short a n d long t e r m r e s u l t s after endoscopic t r e a t m e n t i n p a t i e n t s w i t h b i l i a r y s u m p s y n d r o m e . (Abstract# G2166) C Mavrogiannis, C Liatsos, A Romanos, S G0ulas, A Nak0s and G Karvountzis. Athens, Greece Effect of d i m e t h y l s u l f o x i d e w i t h m e t h y l - t e r t - b u t y l e t h e r a n d ethyl p r o p i o n a t e i n d i s s o l v i n g capacity of cholesterol gallstones in ~tro. (Abstract# G2143) MS Joo, DH Lee, W Choi, PS Kim and YS Kim. Inchon, Korea

D D W Poster of Distinction: D u o d e n o g a s t r i c reflux after b i l i a r y surgery. S c i n t i g r a p h i c q u a n t i t a t i o n a n d i m p r o v e m e n t with e r y t h r o m y c i n . (Abstract# G2123) A Fountos, N Karyotakis, J Tsiaoussis, N Karkavitsas, E Xynos and JS Vassflakis. Crete, Greece

P a p i l l a r y s t r u c t u r e is n o t affected b y e n d o s c o p i c p a p i l l a r y b a l l o o n dilation. (Abstract# G2147) Y K0matsu, H Isayama, T Takemura, K Tateishi, N Toda, M Ohhashi, M Yamagata, M Tada, H Yoshida, T Kawabe, Y Shiratori and M Omata. Tokyo, Japan P r e o p e r a t i v e t h e r a p e u t i c a l splitting: u p to d a t e or out of date for complicated gallstone disease? (Abstract# G2225) P Sungler, J H01zinger, F Mayer, HW Waclawiczek and O Boeckl. Salzburg, Austria Follow-up of more t h a n 10 y e a r s after e n d o s c o p i c s p h i n c t e r o t o m y for c o m m o n bile duct stones i n y o u n g patients. (Abstract# G2221) M Sugiyama, M Tokuhara, N Hatano, M Nakashima, T Mori and Y Atomi. Tokyo, Japan Gallstones a n d the d e v e l o p m e n t of g a l l b l a d d e r cancer. (Abstract# G2126) U Gustafsson, C Einarss0n, L Erikss0n, S Sahlin, B Tribukait and V Gadaleanu. Huddinge and Stockholm, Sweden ERCP f i n d i n g s i n p a t i e n t s w i t h n o n - d i l a t e d bile duct o n p r e v i o u s u l t r a s o u n d e x a m i n a t i o n . (Abstract# G2182) P Netzer, M Pic0zzi, S Gerber, M Essig, U Scheurer, C Gaia, R Bruendler, D Heinrich, F Halter and A Schmassmann. Bern, Switzerland

April 1998

P R O G R A M OF T H E ANNUAL M E E T I N G P221

A G A P O S T E R S E S S I O N - - W E D N E S D A Y , M A Y 20, 1998 E n d o s c o p i c t r e a t m e n t of p o s t o p e r a t i v e biliary: s t r i c t u r e s : m e d i u m t e r m r e s u l t s of a n "aggressive" approach. (Abstract# G2114) G Costamagna, M Mutignani, V Perri, M Pandolfi, C Spada and F Crucitti. Rome, Italy G A S T R O I N T E S T I N A L ONCOLOGY - - MARKERS OF CANCER R I S K AND P R O G R E S S I O N

DDW Poster of Distinction: I d e n t i f i c a t i o n of a biologically active, cell t a r g e t i n g p e p t i d e s e q u e n c e u s i n g p h a g e display. (Abstract# G2641) L Mazzucchelli, JB Burritt, AJ Jesaitis, A Nusrat, TW Liang, AT Gewirtz and CA Parkos. Boston, MA; Atlanta, GA and Bozeman, MT The h u m a n g a s t r o i n t e s t i n a l t r a c t is a r e s e r v o i r for J C v i r u s infection. (Abstract# G2753) L Ricciardiell0, P Ramamirtham, A Randolph, L Laghi, J Neel and CR Boland. San Diego, CA and Ann Arbor, MI A p h e n o t y p i c s i m i l a r i t y of small i n t e s t i n a l n e o p l a s i a with colonic epithelium as detected by a novel

Estrogens m o d u l a t e g a s t r o d u o d e n a l h y p e r p l a s i a a n d dysplasia i n d u c e d b y N-methyl-N'-nitro-Nn i t r o s o g u a n i d i n e i n rats. (Abstract# G2347) M Campbell-Thompson, KK Reyher, GY Lauwers and KT Shiverick. Gainesville, FL M e c h a n i s m of i n h i b i t i o n of b e n z o ( a ) p y r e n e - i n d u c e d forestomach c a n c e r i n mice b y d i e t a r y c u r c u m i n . (Abstract# G2714) JL Orchard, X Hu, H Xia, SK Srivastava and SV Singh. Pittsburgh, PA Folic acid deficiency a l t e r e d e x p r e s s i o n of aryl h y d r o c a r b o n r e c e p t o r i n h e p a t o m a ceils: a possible l i n k to carcinogenesis. (Abstract# G 2 9 3 1 ) J Zhang, S Henning and VLW Go. Los Angeles, CA High levels of p r o g a s t r i n s i g n i f i c a n t l y i n c r e a s e p r e m a l i g n a n t changes i n colonic m u c o s a of mice i n r e s p o n s e to t h e chemical c a r c i n o a g e n , AOM. (Abstract# G2810) P Singh, M Velasco, R Given, A Owlia, M Wargovich and TC Wang. Galveston and Houston, TX; Boston, MA

m o n o c l o n a l a n t i b o d y . (Abstract# G2321) S Borra, EK Onuma, V Mohan and KM Das. New Brunswick and Lyons, NJ

Western stress diet m o d u l a t e s colonic b i o m a r k e r s b u t does n o t p r o m o t e AOM-induced colonic carcinogenesis i n the mouse. (Abstract# G2270) D Ahnen, L Driggers and G Quan. Denver, CO

Reg I p r o t e i n l o c a l i z a t i o n i n colonic m u c o s a at risk for neoplasia. (Abstract# G2615) JL Levine, J Kilcullen, JJ Steinberg and ME Zenilman. Bronx, NY

Deoxycholic acid s t i m u l a t e s m i g r a t i o n i n colon c a n c e r cells. (Abstract# G2651) V Milovic, GM Murphy, RH Dowling, WF Caspary and J Stein. Frankfurt, Germany and London, United Kingdom

E l e v a t e d n o n - o x i d a t i v e p e n t o s e p a t h w a y activity: a n e w r i s k m a r k e r for colon cancer. (Abstract# G2280) D Antoniou, SN Porter, IC Roberts-Thomson and RN Butler. North Adelaide and Woodville, Australia

Short-chain f a t t y acids r e g u l a t e s t h e m o t i l i t y of h u m a n c a r c i n o m a cells. (Abstract# G3219) R Kumar, M Mandal, G Steinbach and L Adam. Houston, TX

Maximal catalytic a c t i v i t y of the non-oxidative pentose p a t h w a y : a n e w m a r k e r of colonic t r a n s f o r m a t i o n . (Abstract# G2341) RN Butler, D Antoniou, W Butler, S Porter and G McIntosh. North Adelaide, Woodville and Adelaide, Australia

Loss of n e u r a l cell a d h e s i o n m o l e c u l e e x p r e s s i o n due to RNA t r a n s f o r m a t i o n defect i n colon c a n c e r cell lines. (Abstract# G2522) S Huerta, HC li, T Blinman, ES Srivatsan and EH Livingston. Los Angeles, CA

Association b e t w e e n m a n g a n e s e superoxide d i s m u t a s e

I n t e r l e n k i n - 1 0 r e s u l t s i n loss of n e u r a l cell a d h e s i o n molecule e x p r e s s i o n i n colon c a r c i n o m a . (Abstract# G2793) J Sebastian, S Huerta, T Blinman and EH Livingston. Los Angeles, CA

and the human colorectal cancer sequence. (Abstract#

G2532) AML Janssen, CB Bosman, L Kruidenier, CFM Sier, MM Oostendorp-van de Ruit, G Griffioen, CBHW Lamers and HW Verspaget. Leiden, The Netherlands O v e r e x p r e s s i o n of p t e r i n - 4 a - c a r b i n o l a m i n e d e h y d r a t a s e i n colon cancers. (Abstract# G2427) R Eskinazi, P Robberecht, J-L Van Laethem and A l~sibois. Brussels, Belgium p53 p r o t e c t s a g a i n s t the d e v e l o p m e n t of dysplasia i n d e x t r a n s u l f a t e - i n d u c e d colitis. (Abstract# G2748) M Reaves, T Lin, J Madsen and DR Green. San Diego, CA and New Haven, CT G A S T R O I N T E S T I N A L ONCOLOGY - - PRECLINICAL CARCINOGENESIS, INVASION AND METASTASIS

DDW Poster of Distinction: Cellular c h a r a c t e r i z a t i o n a n d successful t r a n s f e c t i o n of serially s u b c u l t u r e d n o r m a l h u m a n esophageal k e r a t i n o c y t e s . (Abstract# G2712) OG Opitz, CC Compt0n, G Warland, H Nakagawa, K T0gawa and AK Rustgi. Boston, MA

Decreased m e m b r a n e d i s t r i b u t i o n of E - c a d h e r i n results i n poor cell-cell a d h e s i o n i n a h i g h l y i n v a s i v e p a n c r e a t i c a d e n o c a r c i n o m a , PC-1. (Abstract# G2752) G Rhodes, S Yang, J Marrs and T Howard. Indianapolis, IN Loss of epithelial m a r k e r s a n d a c q u i s i t i o n of v i m e n t i n expression f u r t h e r m i g r a t o r y a n d i n v a s i v e abilities of h u m a n colon c a n c e r cells LoVo C5. (Abstract# G2410) J Dumortier, N Daemi, C P0urreyron, W Anderson, C Bellat0n, MF Jacquier, JA Chayvialle and L Remy. Lyon, France I n c r e a s e d t y r o s i n e p h o s p h o r y l a t e d ~-catenin is associated w i t h cancer cell i n v a s i o n a n d metastasis. (Abstract# G2623) M Maemura, S Takao, H Obama, M Ozawa and T Aikou. Kagoshima, Japan

DDW Poster of Distinction: Overexpression of s e r i n e p r o t e a s e s i n p a n c r e a t i c cancer. (Abstract# G2890) C Wallrapp, F MueUer-Pillasch, V EUenrieder, S H~ihnel, U Lacher, H Friess, M Buechler, H-G Beger, G Adler and TM Gress. Ulm, Germany and Bern, Switzerland

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GASTROENTEROLOGYVol. 114~No. 4

A G A P O S T E R S E S S I O N - - W E D N E S D A Y , MAY 20, 1998 E x p r e s s i o n of MT-MMPs i n p a n c r e a t i c c a n c e r a n d c h r o n i c p a n c r e a t i t i s . (Abstract# G2418) V Ellenrieder, B Alber, U Lacher, H Friess, M Biichler, HG Beget, G Adler and TM Gress. Ulm, Germany and Bern, Switzerland C h a r a c t e r i z a t i o n of t o l e r a n c e d u r i n g p r o l o n g e d dosing of i n t r a v e n o u s r a n i t i d i n e i n ICU p a t i e n t s u s i n g mechanism-based pharmacokinetic-pharmacodynamic modelling. (Abstract# G0896) RAA Math6t, AATMM Vinks, CBHW Lamers and WP Geus. The Hague and Leiden, The Netherlands I n c r e a s e d MMP-2:TIMP-2 r a t i o i n a d v a n c e d colorectal carcinomas. (Abstract# G2356) CC Chan, S Weg-Remers, H-D Orzechowski, N Orendain, M Zeitz and A Stallmach. Taipei, Taiwan and Berlin, Germany U p r e g u l a t i o n of collagen XVIII RNA expression i n colorectal c a r c i n o m a s a n d colorectal liver metastases. (Abstract# G2484) U Giinther, M Bauer, H Herbst, C Isbert, N Runkel, HJ Buhr, EO Riecken and D Schuppan. Berlin, Hamburg and Erlangen, Germany Ectopic e x p r e s s i o n of MUC5 gastric m u c i n i n colorectal a d e n o c a r c i n o m a . (Abstract# G2343) JC Byrd, LR Sternberg, P Yah, SB Ho and RS Bresalier. Detroit, MI and Minneapolis, MN A b e r r a n t e x p r e s s i o n of MUC2 i n t e s t i n a l m u c i n a n d MUC6 gastric m u c i n i n B a r r e t t ' s esophagus a n d esophageal a d e n o c a r c i n o m a . (Abstract# G2342) JC Byrd, P Yan and RS Bresalier. Detroit, MI The e x p r e s s i o n of m u c i n gene p r o d u c t s i n m u c i n o u s colorectal c a r c i n o m a . (Abstract# G2297) SH Baek, JC Hong, HS Chae, CK Montgomery, SB Ho, SF Kuan, JP Terdiman, KR McQuaid, MH Sleisenger and YS Kim. San Francisco, CA; Minneapolis, MN and Chicago, IL E x p r e s s i o n of s u c r a s e - i s o m a l t a s e a n d i n t e s t i n a l trefoil factor i n m e t a s t a t i c colon c a r c i n o m a . (Abstract# G2295) M Babyatsky, A Chen, P Jiang, J Lin, M Schwartz and S Itzkowitz. New York, NY G A S T R O I N T E S T I N A L ONCOLOGY - - COLON CANCER C H E M O P R E V E N T I O N A s p i r i n r e v e r s i b l y s u p p r e s s e s t r a n s f o r m i n g growth factor-a e x p r e s s i o n a n d p r o s t a g l a n d i n b i o s y n t h e s i s i n r e c t a l m u c o s a i n p a t i e n t s w i t h a h i s t o r y of a d e n o m a t o u s polyps. (Abstract# G2337) D Buckelew, G Maze, WE Hardman, IL Cameron, KV Speeg and M Lee. San Antonio, TX C h e m o p r e v e n t i o n of colorectal c a n c e r - the m e c h a n i s m of NSAID effect is m u l t i f a c t o r i a l . (Abstract# G2336) W Brown, S Skinner, D Vogiagis, C Malcontenti-Wilson, T deJong, I Van Driel, K Farmer and P O'Brien. Melbourne, Australia The effect of a n t i o x i d a n t a n d w h e a t - b r a n s u p p l e m e n t s o n rectal p r o l i f e r a t i o n i n subjects w i t h p r e v i o u s a d e n o m a t o u s polyps a n d cancer. (Abstract# G2645) GH McIntosh, D Antoniou, RN Butler, PJ Prichard, A Reid and IC Roberts-Thomson. Adelaide, Australia The m e c h a n i s m of c h e m o p r e v e n t i v e effects of soy p r o d u c t s isoflavones i n h u m a n colonic polyps. (Abstract# G2658) S M0barhan, A Keshavarzian, T Frommel, G Chejfec, S Yong, LJW Lu, N Kazi, C P0 and S Fisher. Maywood, IL and Galveston, TX

Diet d i v e r s i t y a n d the a d e n o m a - c a r c i n o m a sequence. (Abstract# G2323) MC Boutron-Ruault, S M~ance, P Senesse and J Faivre. Paris and Dijon, France C h e m o p r e v e n t i o n of colon c a r c i n o g e n e s i s b y d i e t a r y s e l e n o m e t h i o n i n e . (Abstract# G2516) H Holubec, AT Baines, JL Bayse, S Waite, AK Bhattacharyya, LC Clark, CM Payne, DL Earnest and MA Nelson. Tucson, AZ Seleno-L-methionine i n h i b i t s p r o l i f e r a t i o n a n d s t i m u l a t e s apoptosis i n CaCo-2 cells. (Abstract# G2293) T Azam, L Nguyen, J Krishnamurthy, S Mani, A Diamond, S Skarosi, B Scaglione-Sewell and M Bissonnette. Chicago, IL The effect of d i e t a r y folate o n p53 m u t a t i o n s i n t h e d i m e t h y l h y d r a z i n e r a t m o d e l of colon cancer. (Abstract# G2571) YI Kim, M Puchyr, A Medline, RN Salomon, F GraemeCook, SW Choi and JB Mason. Toronto, Canada and Boston, MA Folic acid r e g u l a t i o n of g r o w t h of colon a n d gastric cancer cell lines. (Abstract# G2319) SB Boppana, FH Sarkar, L Liu, Y-W Li, A Khan, O Kucuk, K Mahakala, R Jaszewski, APN Majumdar and JD Dingell. Detroit, MI and Honolulu, HI Ursodeoxycholate a n d a f l u o r i n a t e d a n a l o g u e of 1,25d i h y d r o x y v i t a m i n D3 i n h i b i t a b e r r a n t c r y p t f o r m a t i o n i n the a z o x y m e t h a n e model of r a t colonic carcinogenesis. (Abstract# G2888) R Wali, S Skarosi, J Hart, M Bissonnette, M Sitrin and T Brasitus. Chicago, IL E n h a n c e m e n t of base h y d r o x y l a t i o n by bile acids i n a model of h u m a n colonic m u c o s a l DNA. (Abstract# G2276) H Allgayer, V Stuber, M Kolb and W Kruis. Aalen and Cologne, Germany GASTROINTESTINAL ONCOLOGY - - T H E R A P Y OF GASTROINTESTINAL CANCERS

DDW Poster of Distinction: M a n a g e m e n t of rectal c a r c i n o i d t u m o r s . (Abstract# G2273) T Akasu, K Aikawa, A Takada, Y Tsubosa, K Kubota, S Fujita and Y M0riya. Tokyo, Japan I m p r o v e m e n t of c a r d i o p u l m o n a r y f u n c t i o n i n c a r c i n o i d h e a r t disease b y t r e a t m e n t w i t h octreotide. (Abstract# G2461) RC Funck, K Ehlenz, A Misic, S Freudenberg, W Cassel, M Frank, M Wied, B Maisch and R Arnold. Marburg, Germany E v a l u a t i o n of the a n t i p r o l i f e r a t i v e effect of l a n r e o t i d e or i n t e r f e r o n - a or the c o m b i n a t i o n of b o t h i n t h e t h e r a p y of m e t a s t a t i c n e u r o e n d o c r i n e t u m o r s . (Abstract# G2435) S Faiss, E-O Riecken, B Wiedenmann and the International Lanreotide and Interferon-alpha Study Group. Berlin, Germany T r e a t m e n t of g a s t r o e n t e r o p a n c r e a t i c n e u r o e n d o c r i n e t u m o r s with lanreotide, a n e w l o n g - a c t i n g s o m a t o s t a t i n analogue. (Abstract# G2650) M Migliori, P Tomassetti, GC Montini, S Lalli and R Corinaldesi. Bologna, Italy

April1998

PROGRAMOF THEANNUALMEETINGP223

A G A P O S T E R S E S S I O N m W E D N E S D A Y , M A Y 20, 1998 T a r g e t e d r a d i o p e p t i d e t h e r a p y : high dose i n d i u m - I l l octreotide for n e u r o e n d o c r i n e t u m o r s . (Abstract# G2348) ME Caplin, AK Burroughs, W Miolcarek, AJW Hilson, AL Jones, EJ Wood and JR Buscombe. London, United Kingdom A novel s o m a t o s t a t i n a n a l o g (TT-232) a n d its a n t i p r o l i f e r a t i v e a c t i v i t y o n p a n c r e a t i c cancer. (Abstract# G2608) J-U Lee, R H0sotani, M Wada, T Koshiba, K Fujim0t0, Y Miyamoto, R Doi, S Tsuji, S Nakajima and M Imamura. Ky0to, Japan A p h a s e II t r i a l of 13-cis-retinoic acid a n d i n t e r f e r o n - a i n UICC stage III/IV p a n c r e a t i c cancer. (Abstract# G2329) FH Brembeck, K Schoppmeyer, U Leup01d, C Gornistu, V Keim, J MSssner, EO Riecken and S R0sewicz. Berlin and Leipzig, Germany A d j u v a n t c h e m o t h e r a p y with 5-FU, folinic acid, a n d p l a t i n after r e s e c t i o n for gastric carcinoma: a p r o s p e c t i v e c o n t r o l l e d trial. (Abstract# G2372) J Chipponi, M Huguier, D Pezet, N Basso, JM Hay, P Quendalle, D Jaeck, PL Fagnier and K Slim. F-63000 Clermont-Ferrand, France Modified D2 g a s t r e c t o m y - is it j u s t i f i e d i n p a t i e n t s with a d v a n c e d stage III gastric cancer? (Abstract# G2694) D Nehra, A Evans, ED Srivastava, MC Allison and WG Lewis. Newport, Wales Laparoscopic s u r g e r y for gastric m a l i g n a n c i e s c u r a t i v e wedge r e s e c t i o n for e a r l y cancer a n d leiomyosarcoma. (Abstract# G2723) Y Otani, M Ohgami, T Kubota, K Kumai, M Kitajima and M Mukai. Tokyo, Japan J e j u n a l p o u c h i n t e r p o s i t i o n after p y l o r u s - p r e s e r v i n g g a s t r e c t o m y w i t h vagus n e r v e p r e s e r v a t i o n . (Abstract# G2709) T Ohya, S Ohwada, H Iesato, I Takeyoshi, Y Kawashima, T Ogawa, I Kobayashi, K Kawashima, T Yokomori and Y Morishita. Maebashi, Japan Endoscopic mucosectomy: r e s u l t s i n 30 patients. (Abstract# G2469) M Giovannini, D Bernardini, G Monges and JF Seitz. Marseilles, France D i a g n o s t i c a n d t h e r a p e u t i c value of the endoscopic u l t r a s o u n d - g u i d e d biopsy. Results i n 522 patients. (Abstract# G0062) M Giovannini, G Monges, D Bernardini and JF Seitz. Marseilles, France A novel m e t h o d of endoscopic mucosal r e s e c t i o n u s i n g a m u c i n o u s s u b s t a n c e of s o d i u m h y a l u r o n a t e . (Abstract# G2922) H Yamamoto, T Yube, N Isoda, K Id0, K Kimura and N Kanai. Tochigi, Japan The effect of s h o r t - c o u r s e p r e o p e r a t i v e r a d i o t h e r a p y on the v a s c u l a r i t y of r e c t a l cancer. (Abstract# G2504) AG Heriot, S Edwards, C Finlayson, J Glees and D Kumar. London, United Kingdom N a t u r a l h i s t o r y of r a d i a t i o n proctitis t r e a t e d with topical sucralfate. (Abstract# G2580) R Kochhar, PVJ Sriram, SC Sharma and K Singh. Chandigarh, India

T r a n s a n a l endoscopic m i c r o s u r g e r y : a n easy way for local f o r m a l i n a p p l i c a t i o n i n h e m o r r h a g i c proctitis. (Abstract# G2601) TE Lans, W Bode and EJR de Graaf. Cappelle ad Ijssel, The Netherlands Efficacy of a d j u v a n t c h e m o t h e r a p y w i t h 5FU/leucovorin a n d 5-FU/levamisole i n colon cancer. (Abstract# G2738) R Porschen, A Bermann, T L~ffler, G Haack, K Rettig, Y Anger and G Strohmeyer. Tuebingen, Germany Variability of d i h y d r o p y r i m i d i n e d e s h y d r o g e n a s e activity i n n o r m a l , i n f l a m m a t o r y a n d t u m o r a l tissues of colon a n d liver i n h u m a n s . (Abstract# G2483) R Guimbaud, S Guichard, V Bertrand, T Aparici0, C Terret, R Bugat, D Couturier, E Chatelut, P Canal and S Chaussade. Toulouse, France I n t r a - a r t e r i a l c h e m o t h e r a p y a f t e r r e s e c t i o n of h e p a t i c m e t a s t a s e s of colorectal c a r c i n o m a : p r e l i m i n a r y results. (Abstract# G2462) L Gambiez, H de Moulins, F Denimal, H Porte and P Quandalle. Lille, France Endoscopic r e s e c t i o n of large (>/= 3cm) b e n i g n a n d m a l i g n a n t colorectal polyps i n 302 consecutive p a t i e n t s . (Abstract# G2318) S Bohnacker, F Thonke, U Seitz, KF Binmoeller, B Brand and N Soehendra. Hamburg, Germany Is endoscopic r e s e c t i o n of m a l i g n a n t colorectal polyps sufficient? Long t e r m r e s u l t s of 114 p a t i e n t s . (Abstract# G2794) U Seitz, T Br~utigam, S B0hnacker, F Th0nke, B Brand, KF Binmoeller and N Soehendra. Hamburg, Germany Gene t r a n s f e r of sst2 s o m a t o s t a t i n receptor: a model of gene t h e r a p y for p a n c r e a t i c cancer. (Abstract# G2757) P Rochaix, N Delesque, J-P Est~ve, N Saint-Laurent, JJ Voigt, N Vaysse, C Susini and L Buscail. Toulouse, France A d e n o v i r u s - m e d i a t e d t r a n s d u c t i o n of E s c b e r i e b i a c o l i u r a c i l p h o s p h o r i b o s y l - t r a n s f e r a s e gene sensitizes c a n c e r cells to low c o n c e n t r a t i o n of 5-fluorouracil; a n e w way to overcome the r e s i s t a n c e of c h e m o t h e r a p e u t i c agent. (Abstract# G2538) F Kanai, T Kawakami, M Ohashi, Y Shiratori and M Omata. Tokyo, Japan Neurotensin and nonpeptide n e u r o t e n s i n receptor a n t a g o n i s t c o n t r o l h u m a n colon c a n c e r cell g r o w t h i n cell c u l t u r e a n d i n cells x e n o g r a f t e d i n t o n u d e mice. (Abstract# G2629) JJ Maoret, Y Anini, C Rouyer-Fessard, D Gully and M Laburthe. Paris and Toulouse, France P h a r m a c o l o g i c a l m o d u l a t i o n of t h e i n f l a m m a t o r y r e s p o n s e i n d u c e d b y a b d o m i n a l i r r a d i a t i o n . (Abstract# G2352) M Casadevall, J Pan~s, A Salas, M Moll~, JL Osorio, C Conill, DN Granger and JM Pique. Barcelona, Spain and Shreveport, LA L o v a s t a t i n - i n d u c e d s e n s i t i z a t i o n of colon c a n c e r cells to apoptosis is i n d e p e n d e n t of r a s a n d is r e v e r s e d b y g e r a n y l g e r a n i o l b u t n o t by farnesol. (Abstract# G2268) B Agarwal, B Halmos, s Bhendwal, WG Ramey, SF Moss and PR Holt. New York, NY E n z y m a t i c a n d a n t i s e n s e effects of a specific anti-Ki-ras ribozyme i n v i t r o a n d i n cell c u l t u r e . (Abstract# G2468) CD Giannini, A Piiper, W-K R0th and S Zeuzem. Frankfurt, Germany

P224PROGRAMOF THE ANNUAL MEETING AGA

POSTER

GASTROENTEROLOGY

S E S...S I O N

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VoL 114,No. 4

20, 1998

Antisense PTHrP transfection impairs the proliferative a b i i t y of h u m a n gastric c a n c e r cells. (Abstract# G2275) GK Alipov, M Ito, M Nakashima, Y Ikeda, S Naito, A Ohtsuru, S Yamashita and I Sekine. Nagasaki, Japan

Do dysplastic B a r r e t t ' s cells exhibit a u t o n o m o u s growth? (Abstract# G2893) KK Wang, M Anderson, A Nourbakhsh, M WongKeeSong, P Nijhawan and R Balm. Rochester, MN

P h a r m a c o l o g i c m o d u l a t i o n of ferrochelatase with g r i s e o f u l v i n e n h a n c e s P P IX c o n c e n t r a t i o n i n HT29 cells: i m p l i c a t i o n s for p h o t o d y n a m i c t h e r a p y . (Abstract# G2692) II Nassif, B Bell, R Rego, M Motamedi, J Winston and PJ Pasricha. Galveston, TX

DDW Poster of Distinction:

A m a t r i x m e t a l l o p r o t e i n a s e i n h i b i t o r decreases g r o w t h of colon c a n c e r p e r i t o n e a l c a r c i n o m a t o s i s a n d prolongs s u r v i v a l i n BD IX rats. (Abstract# G2282) T Aparicio, S Kermorgant, V Dessirier, MJM Lewin and T Lehy. Paris, France A n t i t u m o r a c t i v i t y of s o m a t o s t a t i n a n a l o g u e s i n 34 metastatic and progressive endocrine g a s t r o e t e r o p a n c r e a t i c t u m o r s . (Abstract# G2283) T Aparicio, M Ducreux, E Mitry, E Bandin, JC Sabourin, M Schlumberger and P Rougier. Villejuif, France E x p r e s s i o n of c h i m e r i c IgG-~ a n d IgG-T receptors w i t h specificity for TAG72. (Abstract# G2517) A Hombach, C Pohl, C Heuser, R Sircar, T Tillmann, V Diehl, W Kruis and H Abken. Cologne, Germany A c h i m e r i c r e c e p t o r t h a t selectively t a r g e t s m e m b r a n e b o u n d c a r c i n o e m b r y o n i c a n t i g e n i n t h e p r e s e n c e of soluble CEA. (Abstract# G2733) C Pohl, A Hombach, C Heuser, R Sircar, T Tillmann, V Diehl, W Kruis and H Abken. Cologne, Germany U p t a k e m e c h a n i s m of i r i n o t e c a n (CPT-11) a n d its m e t a b o l i t e (SN-38) b y h a m s t e r i n t e s t i n a l cells. (Abstract# G2578) K Kobayashi, B Bouscarel, Y Matsuzaki, S Ceryak and H Fromm. Washington, DC; Nippon and Tsukuba, Japan T u m o r g r o w t h u n d e r HAI w i t h l i p o s o m e - e n c a p s u l a t e d 5-FU c o m p a r e d to IV a p p l i c a t i o n i n WAG rats. (Abstract# G2734) U Pohlen, G Bergcr, M Jung, R Rezska, J Regenstein and HJ Buhr. Berlin, Germany Anti-emetic effects of PD154075 (CAM-4261) i n different emetic models i n t h e ferret. (Abstract# G2367) E Chevalier, L Singh and L Di0p. Fresnes, France and Cambridge, United Kingdom

N o r m a l i z a t i o n of i n t r a e s o p h a g e a l p H e n h a n c e s d i f f e r e n t i a t i o n a n d decreases p r o l i f e r a t i o n i n B a r r e t t ' s esophagus. (Abstract# G2725) R Ouatu-Lascar, RC Fitzgerald, MB Omary and G Triadafflopoulos. Palo Alto, CA Confocal fluorescence microscopy of 5 ' - a m i n o l e v u l i n i c a c i d - i n d u c e d p r o t o p o r p h y r i n IX i n h u m a n s q u a m o u s a n d B a r r e t t ' s esophagus. (Abstract# G2389) RS DaCosta, R Saidi, H Ter, L Lilge, J Kost, M Cir0cc0, S Hassaram, G Kandel, P K0rtan, G Haber, T Mang, N Marcon and BC Wilson. Toronto, Canada A l t e r a t i o n i n p53 a n d bcl-2 expression i n esophageal tissues d u r i n g p h o t o d y n a m i c t h e r a p y . (Abstract# G2644) T McGarrity, M Khandelwal and L Peiffer. Hershey, PA P o l y m o r p h i c e x p r e s s i o n of b i o t r a n s f o r m a t i o n enzymes i n B a r r e t t ' s esophagus a n d esophageal c a r c i n o m a s . (Abstract# G2878) EMM van Lieshout, S Dekker, T Wobbes, JBMJ Jansen and WHM Peters. Nijmegen, The Netherlands Glutathione and glutathione-S-transferases in Barrett's epithelium. (Abstract# G1313) EMM van Lieshout, JBMJ Jansen and WHM Peters. Nijmegen, The Netherlands M u l t i m o d a l i t y a p p r o a c h for a d v a n c e d esophageal carcinoma. (Abstract# G2761) H Rosen, M Hejna, G Kornek, A Schratter-Sehn, M Raderer, W Scheithauer and R Schiessel. Vienna, Austria

DDW Poster of Distinction: Endoscopic i n t r a t u m o r a l i n j e c t i o n of c i s p l a t i n / e p i n e p h r i n e as p a l l i a t i o n for a d v a n c e d esophageal a n d gastric cancer: long t e r m outcome. (Abstract# G2660) SPS Monga, R Wadleigh, H Adib and L Mishra. Washington, DC and Philadelphia, PA

G A S T R O I N T E S T I N A L ONCOLOGY - - BARRETT'S E S O P H A G U S AND E S O P H A G E A L CARCINOMA

Endoscopic i n j e c t i o n of m i t o m y c i n a d s o r b e d o n a c t i v a t e d c a r b o n p a r t i c l e s versus b r a c h y t h e r a p y for a d v a n c e d esophageal cancer. (Abstract# G2721) M Ortner, A Buchali, S Dinges, A Taha, J Weber, J Wirth and H Lochs. Berlin, Germany

S u r v e i l l a n c e of B a r r e t t ' s esophagus i n The N e t h e r l a n d s : a postal q u e s t i o n n a i r e , (Abstract# G2880) JW van Sandick, JFWM Bartelsman, JJB van Lanschot, GNJ Tytgat and H Obertop. Amsterdam, The Netherlands

P a l l i a t i o n of esophageal a n d colorectal c a n c e r w i t h YAG laser: q u a l i t y of life assessments. (Abstract# G2665) DG Morgan and JG Belbeck. Hamilton, Canada

E a r l y a d e n o c a r c i n o m a of the esophagus a n d g a s t r o e s o p h a g e a l j u n c t i o n : pathologic features a n d outcome after resection. (Abstract# G2879) JW van Sandick, JJB van Lanschot and H Gbertop. Amsterdam, The Netherlands

A n e w t a p e r e d a n d covered Wallstent for i n o p e r a b l e c a r c i n o m a of esophagus a n d cardia. (Abstract# G2808) PD Siersema, WCJ Hop and J Dees. Rotterdam, The Netherlands

Quantitative pathologic features in surveillance biopsies of B a r r e t t ' s esophagus. (Abstract# G1314) JW van Sandick, JJB van Lanschot, JPA Baak, W Polkowski, FJW ten Kate, H Obertop and GJA Offerhaus. Amsterdam and Alkmaar, The Netherlands Does n o n - d y s p l a s t i c B a r r e t t ' s e p i t h e l i u m r e s p o n d b e t t e r to m u c o s a l a b l a t i o n ? (Abstract# G2894) KK Wang, M WongKeeSong, P Nijhawan, A Nourbakhsh and R Balm. Rochester, MN

Esophageal s t e n t i n g for m a l i g n a n t esophagorespiratory fistula - a comparison between self-expanding m e s h - m e m b r a n e s t e n t v e r s u s plastic stent. (Abstract# G2862) CI Tsai, WY Lee, CH Chen, YG Chang, TH Yang, HY Tsai, JT Lin and TH Wang. Lotung and Taipei, Taiwan

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A G A P O S T E R S E S S I O N m W E D N E S D A Y , M A Y 20, 1998 I n i t i a l e x p e r i e n c e of self-expanding metal stents for p a l l i a t i o n of s y m p t o m s d u e to s t e n o s i n g rectosigmoid c a r c i n o m a . (Abstract# G2909) N Wight, P Sherwood, A Duggan, A Cole and J Freeman. Derby, United Kingdom P a l l i a t i o n of m a l i g n a n t g a s t r o i n t e s t i n a l stenoses i n u n u s u a l locations w i t h self e x p a n d a b l e metal stents. (Abstract# G2803) YJ Shin, J H Kim, KJ Lee, IR Hwang, BM You, YS Kim and SW Ch0. Suwon, Korea A pilot s t u d y of b i p o l a r e l e c t r o c a u t e r y scissors i n l y m p h a d e n e c t o m y for esophageal cancer. (Abstract# G2403) S Dresner, J Wayman, A Harris, SA Raimes and SM Griffin. Newcastle upon Tyne, United Kingdom Site a n d histological type of esophageal a n d gastric cancer: r e t r o s p e c t i v e p o p u l a t i o n - b a s e d case note s u r v e y of over 1,000 cases. (Abstract# G2344) JP Byrne, J Mathers, J Parry, CBJ Woodman and SEA Attwood. Manchester, United Kingdom E n d o s c o p i c m u c o s e c t o m y of early a d e n o c a r c i n o m a i n p a t i e n t s w i t h B a r r e t t ' s esophagus. (Abstract# G2417) C Ell, A May, L Gossner, E Gfinter, G Mayer, R Henrich and M Stolte. Wiesbaden and Bayreuth, Germany A u n i q u e p a t t e r n of c y t o k e r a t i n expression d i s t i n g u i s h e s a d e n o c a r c i n o m a associated with B a r r e t t ' s esophagus from a d e n o c a r c i n o m a of the stomach. (Abstract# G2716) AH Ormsby, JR Goldblum, TW Rice and TL Gramlich. Cleveland, OH Are histologic f e a t u r e s useful i n p r e d i c t i n g prognosis i n p a t i e n t s w i t h s u b m u c o s a l esophageal a d e n o c a r c i n o m a ? (Abstract# G2717) AH Ormsby, LA Rybicki, TW Rice and JR Goldblum. Cleveland, OH CD44 v a r i a n t 6 e x p r e s s i o n is associated with poor p r o g n o s i s i n superficial esophageal a d e n o c a r c i n o m a . (Abstract# G2718) AH Ormsby, TW Rice, LA Rybicki and JR G01dblum. Cleveland, OH p53 m u t a t i o n e x p r e s s i o n is n o t associated with poor p r o g n o s i s i n superficial esophageal a d e n o c a r c i n o m a . (Abstract# G2719) AH Ormsby, LA Rybicki, TW Rice and JR Goldblum. Cleveland, OH MOTILITY AND N E R V E - G U T INTERACTIONS - E S O P H A G E A L MOTILITY E s o p h a g e a l h y p e r m o t i l i t y i n p a t i e n t s with chest p a i n a n d a r t e r i a l h y p e r t e n s i o n . (Abstract# G2941) RJ Adamek, C Szymanski, D Hagemann, K Baumgarten and B Pfaffenbach. Bochum, Germany E v a l u a t i o n of esophageal f u n c t i o n i n p a t i e n t s with progressive systemic sclerosis w i t h a s t a n d a r d i z e d s y m p t o m score. (Abstract# G3212) H KShler, B Pfaffenbach, D Hagemann, C Szymanski and RJ Adamek. Bochum, Germany Long t e r m fallow-up of achalasic p a t i e n t s t r e a t e d with b o t u l i n u m toxin. (Abstract# G3074) V D'Onofrio, V Annese, N GiarduUo, A Marasco, A Andriulli and G Iaquinto. Avellino and Foggia, Italy

Esophageal m a n o m e t r y : h o w does t h e p a t i e n t feel a b o u t it? (Abstract# G3268) G Lock, H Herfarth, M Wimmer, E Busch and J SchSlmerich. Regensburg, Germany I d i o p a t h i c a n d reflux-associated diffuse esophageal spasm: a lack of d i f f e r e n t i a t i o n b y m a n o m e t r y . (Abstract# G3457) AF Steinlauf, Y Sandman and M Traube. New Haven, CT A m b u l a t o r y esophageal m a n o m e t r y i n p e d i a t r i c p a t i e n t s . (Abstract# G3503) G Veereman-Wauters, C Algoet, I Hoffman, M Van Den Driessche, D Sifrim and J Tack. Leuven, Belgium What's the difference of esophageal m o t i l i t y b e t w e e n GERD w i t h a n d w i t h o u t reflux esophagitis? (Abstract# G3238) KJ Lee, JM Kim, JH Kim, KB Hahm and SW Cho. Suwon, Korea Esophageal m o t i l i t y i n p a t h o l o g i c a l l y obese p a t i e n t s : a m u l t i d i s c i p l i n a r y approach. (Abstract# G3467) E Surrenti, G Ciancio, S Carloppi, R Caramelli, A Coppola, M Lucchese and C Surrenti. Florence, Italy Effect of i n t r a g a s t r i c p r e s s u r e o n belch-associated esophageal c o m m o n c a v i t y reflux events. (Abstract# G3287) BT Massey, JM Corny, C Hofmann and RC Arndorfer. Milwaukee, WI Laparoscopic Heller m y o t o m y w i t h f u n d o p l i c a t i o n : p o t e n t i a l first line t r e a t m e n t for achalasia. (Abstract# G3434) V Shayani, K Bruninga and A Keshavarzian. Maywood, IL Normal values of esophageal m o t i l i t y i n a L a t i n p o p u l a t i o n differ from t h e s t a t i o n a r y to the 24 h o u r a m b u l a t o r y procedure. (Abstract# G2956) R Awad, S Camacho, A Toriz, R Santiago, F Bernal and R Obregon. Mexico City, Mexico I n f l u e n c e of the physiological activities of m i c t i o n a n d defecation over esophageal m o t i l i t y i n h e a l t h y subjects a n d GERD patients. (Abstract# G2955) R Awad, R Santiago, S Camach0 and A Toriz. Mexico City, Mexico Is t h e t r a n s a b d o m i n a l c o m p r e s s i o n test a sufficient m e t h o d to evaluate the c o m p e t e n c y of the lower esophageal s p h i n c t e r ? (Abstract# G3193) WKH Kauer, HJ Stein and JR Siewert. Munich, Germany Lower esophageal s p h i n c t e r r e s t i n g p r e s s u r e a n d esophageal acid a n d bile exposure i n p a t i e n t s with s h o r t a n d long s e g m e n t B a r r e t t ' s esophagus. (Abstract# G0696) WKH Kauer, HJ Stein, HJ Dittler and JR Siewert. Munich, Germany C o m p a r a t i v e t r e a t m e n t of Chagas disease a n d a c h a l a s i a with b o t u l i n u m toxin. (Abstract# G3464) E Suarez, G Arenas, E Perez-Manauta, KR DeVault and SR Achem. Mexico City, Mexico and Jacksonville, FL The use of b o t u l i n u m t o x i n i n achalasia. (Abstract# G3490) D Vakil, E Ianna, R Batey and E Hewson. Newcastle, Australia A "motility diagnostics system" for e v a l u a t i o n of s w a l l o w i n g disorders. (Abstract# G3247) M Li, BA Karhan and JG Brasseur. University Park, PA

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B o t u l i n u m t o x i n i n classical achalasia: l o n g t e r m efficacy a n d p r e d i c t o r s of response. (Abstract# G3213) J Kolbasnik, B Fachnie, U Chauhan, Y Chen, WE Waterfall and G Tougas. Hamilton, Canada Cortical a n d a u t o n o m i c r e s p o n s e s to p e r c e i v e d versus n o n p e r c e i v e d esophageal s t i m u l i i n h u m a n s . (Abstract# G3159) S H011erbach, MV Kamath, G Shine, D Fitzpatrick, ARM Upton and G Tougas. Regensburg, Germany and Hamilton, Canada MOTILITY AND N E R V E - G U T I N T E R A C T I O N S - F U N C T I O N A L G A S T R O I N T E S T I N A L DISORDERS Interrelationships among functional gastrointestinal disorders. (Abstract# G2978) EJ Bennett, C-A Badcock, CC Tennant and JE Kellow. Sydney, Australia The coexistence of f i b r o m y a l g i a alters r e c t a l p e r c e p t i o n before a n d after s i g m o i d s t i m u l a t i o n i n female IBS p a t i e n t s . (Abstract# G3024) L Chang, EA Mayer, J Munakata, L FitzGerald, M Schmuls0n and B Nalib0ff. Los Angeles and Torrance, CA F a t i g u e a n d t h e i r r i t a b l e bowel s y n d r o m e . (Abstract# G3058) V De Gucht and B Fischler. Leuven, Belgium Idiopathic slow-transit constipation: a sensory and a u t o n o m i c n e u r o p a t h y l i n k e d to H i r s c h s p r u n g ' s disease. (Abstract# G3209) CH Knowles, SM Scott, A Wellmer, VP Misra, M-A Pilot, J Rogers, NS Williams and P Anand. London, United Kingdom Effect of a s h o r t t e r m cognitive b e h a v i o r a l group i n t e r v e n t i o n o n s y m p t o m s a n d q u a l i t y of life i n p a t i e n t s w i t h f u n c t i o n a l bowel disorders. (Abstract# G2962) G Balice, H Raeen, C Liu, L Fitzgerald, T Lembo, B Naliboff and EA Mayer. Los Angeles, CA D o h y s t e r e c t o m i e s affect g a s t r o i n t e s t i n a l m o t i l i t y a n d

visceral n o c i c e p t i o n ? (Abstract# G3527) CH Wilder-Smith, L Hill and L Denny. Cape Town, South Africa Whole gut s e n s i t i v i t y i n c o n s t i p a t i o n p r e d o m i n a n t i r r i t a b l e bowel s y n d r o m e : 80% of p a t i e n t s exhibit a n a b n o r m a l i t y . (Abstract# G3137) RM Hammonds, LA Houghton, PJ Whorwell, J Morris, CY Francis and J Mills. Manchester and Uxbridge, United Kingdom F u n c t i o n a l MRI m e a s u r e m e n t of b r a i n activity d u r i n g rectal distension in normal volunteers and patients w i t h i r r i t a b l e bowel s y n d r o m e . (Abstract# G3301) H Mertz, WG Tanner, D Kessler, R Price and D Pickens. Nashville, TN S y m p t o m beliefs a n d t h e i r r e l a t i o n s h i p to f u n c t i o n a l s t a t u s i n IBS a n d c h r o n i c p a i n . (Abstract# G3327) B Naliboff, DA Williams, K Salters, R Reyes and EA Mayer. Los Angeles, CA and Washington, DC

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Symptom c r i t e r i a a n d severity i n i r r i t a b l e b o w e l s y n d r o m e are associated w i t h r e c t a l s e n s i t i v i t y t h r e s h o l d s before a n d after s i g m o i d s t i m u l a t i o n . (Abstract# G3424) M Schmulson, EA Mayer, J Munakata, L Chang and B Naliboff. Los Angeles, CA D u o d e n a l l i p i d causes a d o s e - d e p e n d e n t c h a n g e i n gastric p e r c e p t i o n a n d s y m p t o m s b u t n o t i n g a s t r i c tone d u r i n g d i s t e n t i o n of t h e stomach. (Abstract# G3101) C Feinle, D Grundy and M Fried. Ziirich, Switzerland and Sheffield, United Kingdom Adequate relief as a e n d p o i n t i n clinical t r i a l s i n i r r i t a b l e bowel syndrome. (Abstract# G3280) A Mangel, B Hahn, A Heath, A Northcutt, S Kong, G Dukes and D McS0rley. Research Triangle Park, NC Associations b e t w e e n use of alcohol, coffee a n d s m o k i n g a n d f u n c t i o n a l bowel s y m p t o m s i n t h e g e n e r a l D u t c h p o p u l a t i o n . (Abstract# G2988) PJ B0ekema, EF van Dam van Isselt, ML Bots and AJPM Smout. Utrecht, The Netherlands I n t r a j e j u n a l c a p s a i c i n causes p a i n i n the h u m a n j e j u n u m . (Abstract# G3136) J Hammer, HF Hammer, AJ Eherer, W Petritsch, P Holzer and GJ Krejs. Graz and Vienna, Austria Symptoms i n f u n c t i o n a l dyspepsia: role of H. pylorl infection a n d delayed gastric e m p t y i n g . (Abstract# G3371) F Perri, R Clemente, V Festa, M Quitadam0, V Annese and A AndriuUi. San Giovanni R0tendo, Italy Gastric e m p t y i n g of solids is d e l a y e d i n celiac disease a n d n o r m a l i z e s after gluten-free diet. (Abstract# G3370) F Perri, A Zicolella, V Festa, M Pastore, R Clemente, M Quitadamo and A Andriulli. San Giovanni Retondo, Italy Parent modeling of illness behavior: the influence of the IBS parents' gender on the n u m b e r of children's h e a l t h care visits for g a s t r o i n t e s t i n a l s y m p t o m s . (Abstract# G3246) RL Levy, WE Whitehead, MR Von K0rff, KW Saunders and AD Feld. Seattle, WA and Chapel Hill, NC Gut-specific a u t o n o m i c t e s t i n g c a n be u s e d to p r e d i c t bowel d y s f u n c t i o n i n s p i n a l cord i n j u r y p a t i e n t s . (Abstract# G3091) AV Emmanuel, MA Kamm and F Middleton. London and Harrow, United Kingdom Effect of d i s t e n t i o n r a t e o n r e c t a l a c c o m m o d a t i o n a n d p e r c e p t i o n i n i r r i t a b l e bowel s y n d r o m e . (Abstract# G2973) G Basilisco, A Dal Lag0, M Corsetti and PA Bianchi. Milan, Italy Are t h e r e c-kit gene m u t a t i o n s i n c h r o n i c i d i o p a t h i c c o n s t i p a t i o n ? (Abstract# G3279) N Malik, R Hagger, P Syrris, N Carter, V Murday and D Kumar. London, United Kingdom I n c r e a s e d small bowel b u t n o t colonic p e r m e a b i l i t y i n post.infectious i r r i t a b l e bowel s y n d r o m e . (Abstract# G3146) JM Hebden, PO Erah, PE Blackshaw, AC Perkins and RC Spiller. Nottingham, United Kingdom Correlation between symtomatic improvement and p a r a m e t e r s of gastric m o t i l i t y after e r y t h r o m y c i n t r e a t m e n t i n p a t i e n t s w i t h dysmotility-like f u n c t i o n a l dyspepsia. (Abstract# G3169) IR Hwang, JH Kim, KJ Lee, JM Kim and SW Cho. Suw0n, Korea

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I n c r e a s e d p r e v a l e n c e of a n t i b o d i e s to p r o t e i n S i n i n f l a m m a t o r y bowel disease. (Abstract# G4533) M Vecchi, S Saibeni, E Faioni, C Valsecchi, MB Bianchi, C Razzari, PM Mannucci and R de Franchis. Milan, Italy S y m p t o m c r i t e r i a for c o n s t i p a t i o n subtypes i n a n U.S. n a t i o n a l epidemiological s t u d y of constipation. (Abstract# G3408) RS Sandler, WF Stewart, JN Liberman, A Stemhagen, CE Farup and MS Woods. Chapel Hill, NC; Towson, MD and Titusville, NJ

Social d e s i r a b i l i t y i n f l u e n c e s self-reported g a s t r o e n t e r o l o g y a n d psychological s y m p t o m s i n w o m e n w i t h i r r i t a b l e bowel s y n d r o m e . (Abstract# G3180) ME Jarrett, M Heitkemper, RL Burr, RL Levy, MK Lustyk and V Hertig. Seattle, WA I r r i t a b l e bowel s y n d r o m e : r e s p o n s e s to gastric d i s t e n t i o n . (Abstract# G3139) M Harnish, S Elsenbruch and W Orr. Oklahoma City, OK

S t r a i n differences i n p r o p e n s i t y to develop visceral h y p e r s e n s i t i v i t y i n t h e rat. (Abstract# G3367) V Pelsser, G Gaudreau and V Plourde. Montreal, Canada

F i b r o m y a l g i a is s t r o n g l y associated with the severity of i n f l a m m a t o r y bowel syndrome. (Abstract# G3176) P Iovino, E Lubrano, M Grazia Ferrucci, P Talento, C Nuvoletta and G Mazzacca. Naples, Italy

Effects of 5-HT3 r e c e p t o r a n t a g o n i s t s on gastric t a c h y a r r h y t h m i a a n d the s y m p t o m s of m o t i o n sickness. (Abstract# G3245) ME Levine, J Chfllas, RM Stern and CW Knox. University Park and Philadelphia, PA

Visceral s e n s i t i z a t i o n i n f u n c t i o n a l bowel disorders occurs p r e d o m i n a n t l y i n p a i n f u l disorders. (Abstract# G2991) M Boivin, P P0itras, RG Lahaie and V Plourde. Montreal, Canada

A pilot s t u d y of t h e effects of biofeedback o n rectal s e n s a t i o n a n d colonic m o t i l i t y i n p a t i e n t s with d i s o r d e r s of r e c t a l e v a c u a t i o n . (Abstract# G3310) R Mollen, B Salvioli, M Camilleri, D Burton, L Kost, SF Phillips and JH Pemberton. Rochester, MN

The economic b u r d e n of i r r i t a b l e bowel s y n d r o m e i n Canada. (Abstract# G2979) JD Bentkover, C Field, EM Greene, V Plourde and JP Casciano. Boston, MA and Montreal, Canada

S o m a t i z a t i o n i n clinical d e p r e s s i o n is associated with a b n o r m a l f u n c t i o n of a b r a i n r e g i o n active i n visceral p a i n p e r c e p t i o n . (Abstract# G3444) DHS Silverman, AL Brody, S Saxena, JA Munakata and BD Naliboff. Los Angeles, CA E v a l u a t i o n of a m u l t i - c o m p o n e n t b e h a v i o r a l t r e a t m e n t for the i r r i t a b l e bowel s y n d r o m e . (Abstract# G3151) I Heymann-M6nnikes, R Arnold, I Florin and H M6nnikes. Marburg, Germany P r e v a l e n c e of Rome c r i t e r i a i n v o l u n t e e r s with a m e d i c a l diagnosis of i r r i t a b l e bowel syndrome. (Abstract# G3006) JL Brooks, FK Statham, M Coke and GJ Davies. London and Hull, United Kingdom Gastric e m p t y i n g is d e l a y e d i n slow colonic t r a n s i t c o n s t i p a t i o n . (Abstract# G2958) D Badiali, N Pallotta, FI Habib, C Frandina, F Anzini and E Corazziari. Rome, Italy Cardiovascular autonomic function and plasma c a t e c h o l a m i n e r e s p o n s e s i n i r r i t a b l e bowel syndrome. (Abstract# G3038) SJ Cole, DBA Silk, A Akinola, K Bleasdale-Barr and CJ Mathias. London, United Kingdom Abnormal central sympathetic function in irritable bowel s y n d r o m e detected w i t h the colonidine-growth h o r m o n e s t i m u l a t i o n test. (Abstract# G3037) SJ Cole, L Watson, JR Kimber, DBA Silk and CJ Mathias. London, United Kingdom A n o v e l sub-classification of i r r i t a b l e bowel s y n d r o m e

v a l i d a t e d b y differences i n p o s t p r a n d i a l colonic m o t o r activity. (Abstract# G3036) SJ Cole, HD Duncan, TE Bowling, AH Raimundo, J Rogers and DBA Silk. London, United Kingdom Clinical r e l e v a n c e of c a r b o h y d r a t e m a l a b s o r p t i o n i n p a t i e n t s w i t h u n s p e c i f i c g a s t r o i n t e s t i n a l symptoms: a prospective study. (Abstract# G3318) SM Muehldorfer, S Schanda, T Loew, T Schneider and EG Hahn. Erlangen-Nuremberg, Germany

D i s t e n s i o n protocols for e v a l u a t i o n of rectal sensitivity: the simplest, t h e best? (Abstract# G2987) C Blanc, M Delvaux, C Maillot, M Bouin, E Lagier, J Fioramonti, L Bu6no and J Frexinos. Toulouse, France I n t r a r e c t a l i n j e c t i o n of glycerol alters rectal t o n e a n d i n d u c e s h y p e r s e n s i t i v i t y to l u m i n a l d i s t e n s i o n i n h e a l t h y v o l u n t e e r s . (Abstract# G2997) M Bouin, M Delvaux, E Lagier, C Blanc, J Fioramonti, L Bu~no and J Frexinos. Toulouse, France P a t i e n t s w i t h i r r i t a b l e bowel s y n d r o m e p a y selective a t t e n t i o n to g a s t r o i n t e s t i n a l s e n s a t i o n s . (Abstract# G3526) WE Whitehead, O Palsson, RL Levy, NA Gibbs and KB Meyer. Chapel Hill, NC; Norfolk, VA and Seattle, WA Can s y m p t o m s d i s t i n g u i s h s u b t y p e s of c o n s t i p a t i o n ? (Abstract# G3524) WE Whitehead, C Burnett, 0 Palsson and D Drossman. Chapel Hill, NC and Norfolk, VA Acute stress i n c r e a s e s t h e vagal r e s p o n s e to gastric d i s t e n t i o n i n a r a t model of cholinergic h y p e r s e n s i t i v i t y . (Abstract# G3517) L Wang, Y Chen, V Djuric, M Steiner, DH Overstreet and G Tougas. Hamilton, Canada and Chapel Hill, NC The clinical u t i l i t y of s y m p t o m s a s s e s s m e n t i n p a t i e n t s with f u n c t i o n a l dyspepsia. (Abstract# G3324) ER Muth, KL Koch, SA Bingaman.and RM Stern. Pensacola, FL and Hershey, PA Characteristics of m o t o r p a t t e r n s of the p y l o r u s i n p a t i e n t s w i t h i n f a n t i l e h y p e r t r o p h i c pyloric stenosis. (Abstract# G3194) H Kawahara, K Imura and J Dent. Osaka, Japan and Adelaide, Australia Differences i n m o t o r a n d s e n s o r y p a r a m e t e r s m e a s u r e d by gastric b a r o s t a t a c c o r d i n g to i n d i v i d u a l s y m p t o m s i n f u n c t i o n a l dyspepsia. (Abstract# G3203) YH Kim, PL Rhee, HJ Son, J Kim, KC Koh, SW Paik, JC Rhee and KW Choi. Seoul, Korea P r e t r e a t m e n t gastric t a e h y a r r h y t h m i a p r e d i c t s n a u s e a following c h e m o t h e r a p y . (Abstract# G3458) RM Stern, PJ Gianaros, GR Morrow, JT Hickok and JA Roscoe. University Park, PA and Rochester, NY

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A G A P O S T E R S E S S I O N - - W E D N E S D A Y , M A Y 20, 1998 Clinical a d v e r s e e v e n t s o b s e r v e d d u r i n g oral placebo treatment in patients with functional gastrointestinal disorders. (Abstract# G2939) J-L Abitbol, F Weber, H Math~ and B Scherrer. Fresnes, France F a c t o r s associated w i t h h e a l t h care s e e k i n g i n i r r i t a b l e bowel s y n d r o m e . (Abstract# G3331) MK Newcomer, MJ Shaw, TJ Beebe, SA Adlis and NJ Talley. Minneapolis, MN and Penrith, Australia I n f l u e n c e of psychological factors o n h e a l t h care s e e k i n g b e h a v i o r i n i r r i t a b l e bowel syndrome. (Abstract# G3419) S Scheuner, JE Gomborone, Z Mahmood and LJD O'Donnell. Castlebar, Ireland and London, United Kingdom Demographic, clinical c h a r a c t e r i s t i c s , psychological profiles, t r e a t m e n t a n d follow-up of gastroparesis. (Abstract# G3449) I Soykan, I Sarosiek, B Sivri and RW McCallum. Kansas City, KS I n h i b i t o r y effect of w h i t e w i n e o n gastric myoelectrical activity a n d its c o r r e l a t i o n w i t h vagal activity. (Abstract# G3244) D Levanon, XP Zeu and JDZ Chen. Oklahoma City, OK R e l i a b i l i t y of a modified S i t z m a r k s t u d y of whole gut t r a n s i t time. (Abstract# G3210) JB Knowles, WE Whitehead and KB Meyer. Chapel Hill, NC "Bowel obsessions": a d i a g n o s t i c myth. (Abstract# G3342) KW Olden and SS Horn. San Francisco, CA C h r o n i c a b d o m i n a l p a i n i n c h i l d r e n - beliefs a n d expectations. (Abstract# G3443) T Sigman, A Dover, C Duffy and A Rasquin. Montreal, Canada 5-HT4 a n t a g o n i s m i n i r r i t a b l e bowel syndrome: effect of SB-207266-A o n r e c t a l s e n s i t i v i t y a n d small bowel t r a n s i t . (Abstract# G3164) LA Houghton, NA Jackson, PJ Whorwell and S Cooper. Manchester and Harlow, United Kingdom P r e v a l e n c e of d y s p e p s i a a n d o t h e r GI c o m p l a i n t s i n p a t i e n t s t r e a t e d for p s y c h o s o m a t i c disorders. (Abstract# G3222) S-U Kutscher, G Holtmann, G Heuft, J Neufang-Hiiber, W Senf, H Goebell and NJ Talley. Essen, Germany U t i l i t y of s c r e e n i n g tests i n i r r i t a b l e bowel syndrome. (Abstract# G3135) LR Hamm, SC Sorrells, JP Harding, AR Northcutt, AT Heath, GF Kapke and AW Mangel. Research Triangle Park, NC and Indianapolis, IN Autogenic feedback t r a i n i n g as a p o t e n t i a l t r e a t m e n t for the s y m p t o m s of gastroparesis. (Abstract# G3387) H Rashed, P C0wings, W Toscano, T Abell and S Cardoso. Ames and Los Angeles, CA; Memphis, TN C e n t r a l m o d u l a t i o n of colorectal d i s t e n s i o n - i n d u c e d blood p r e s s u r e c h a n g e s b y alosetron, a 5HT 3 r e c e p t o r a n t a g o n i s t . (Abstract# G3309) M Miura, DC Lawson, A Mangel, E Clary and TN Pappas. Durham and Research Triangle Park, NC C h r o n i c a b d o m i n a l p a i n i m p a c t s psychosocial s t a t u s a n d h e a l t h - r e l a t e d q u a l i t y of life. (Abstract# G2969) I Barofsky, C Biskup, VA Schettler-Duncan and MD Crowell. Baltimore, MD

Achalasia of the esophagus: the e s o p h a g e a l b o d y m o t o r activity before a n d after surgical t r e a t m e n t . A 24-hour a m b u l a t o r y esophageal m a n o m e t r y study. (Abstract# G3070) N Di Martino, M Bortolotti, G Izzo, G Amato, B Sodano, L Monaco and A Del Genie. Naples and Bologna, Italy A u t o n o m i c a n d n e u r o e n d o c r i n e r e s p o n s e s to rectosigmoid s t i m u l a t i o n . (Abstract# G3322) J Munakata, EA Mayer, L Chang, M Schmulson, M Liu, G Tougas, M Kamath and B Naliboff. Los Angeles, CA and Hamilton, Canada Effect of c h o l e c y s t o k i n i n o n rectal c o m p l i a n c e a n d p e r c e p t i o n i n i r r i t a b l e bowel s y n d r o m e . (Abstract# G3223) J Kuyvenhoven, PJ van der Schaar, CBHW Lamers and AAM Masclee. Leiden, The Netherlands T r e a t m e n t of c o n s t i p a t i o n i n c h i l d r e n : five-year followu p results. (Abstract# G3499) R van Ginkel, SD Kuiken, RN van der Plas, MA Benninga and JAJM Taminiau. Amsterdam, The Netherlands Hollow viscera n e u r o p a t h y i n c h i l d r e n w i t h i n t r a c t a b l e c o n s t i p a t i o n a n d u r i n a r y t r a c t symptoms. (Abstract# G3067) C Di Lorenzo, C Lucanto, SB Bauer, PE Hyman and AF Flores. Pittsburgh, PA; Boston and Newton, MA; Orange County, CA Perceived straining and incomplete evacuation predict p a r a d o x i c a l c o n t r a c t i o n of the pelvic floor. (Abstract# G3050) MD CroweU, B Lacy and MM Schuster. Baltimore, MD Pelvic floor d y s f u n c t i o n i n w o m e n w i t h a n t e r i o r rectocele. (Abstract# G3049) MD Crowell, R Genedry, B Lacy, SF Sherif and MM Schuster. Baltimore, MD C h r o n i c a b d o m i n a l p a i n : a m u l t i v a r i a t e a n a l y s i s of psychological distress. (Abstract# G3047) MD Crowell. Baltimore, MD Fecal i n c o n t i n e n c e : i m p a c t o n psychosocial f u n c t i o n a n d h e a l t h - r e l a t e d q u a l i t y of life. (Abstract# G3048) MD Crowell, VA Schettler-Duncan, K Brookhart and I Barofsky. Baltimore, MD Fecal i n c o n t i n e n c e i n a n u r s i n g h o m e a n d a n a m b u l a t o r y p o p u l a t i o n . (Abstract# G3243) FW Leung, NC Karyotakis, HU Rahman, CE Marshall, JM Brazier and MJ Rosenthal. Los Angeles, CA IMMUNOLOGY, MICROBIOLOGY, AND INFLAMMATORY DISORDERS - - E P I T H E L I A L CELL IMMUNE F U N C T I O N S

DDW Poster of Distinction: P r o d u c t i o n of TcH1 h e l p e r T cell-associated cytokine, interleukin-18 i n h u m a n colonic e p i t h e l i a l cells. (Abstract# G3788) T Ashida, D Frederick and H Takahashi. Boston, MA Fas l i g a n d expression b y n o r m a l h u m a n esophageal s q u a m o u s e p i t h e l i u m - a n o t h e r site of i m m u n e privilege. (Abstract# G3810) MW Bennett, J O'Connell, GC O'Sullivan, D Roche, C Brady, J Kelly, JK Collins and F Shanahan. Cork, Ireland M e c h a n i s m s of e n t e r o c y t e phagocytosis a n d k i l l i n g of microorganisms. (Abstract# G4557) KB Wilkins, M Brengman, T Owaki, E Smith, C Wells and GB Bulkley. Baltimore, MD

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C D l d localizes to t h e apical a n d l a t e r a l cell surface of h u m a n i n t e s t i n a l e p i t h e l i a l cells. (Abstract# G4453) K Somnay-Wadgaonkar, A Nusrat, W Canchis, SP Colgan, SP Balk and RS Blumberg. Boston, MA and Atlanta, GA G l u t a m i n e 108 is critical for i n t e r l e u k i n - 1 5 f u n c t i o n i n p e r i p h e r a l blood m o n o n u c l e a r cells a n d i n t e s t i n a l e p i t h e l i a l cells. (Abstract# G4465) AC Stevens, YS Kim, D-W Chae, AD Schachter, TB Strom and W Maslinski. Boston, MA I n t e s t i n a l e p i t h e l i a l cell d i f f e r e n t i a t i o n i m p a i r s c h e m o k i n e e x p r e s s i o n i n d u c e d b y the i n t e r l e u k i n - 1 s i g n a l l i n g p a t h w a y . (Abstract# G3834) U BScker, C J0bin, L H01t, L Licato, D Brenner and RB Sartor. Chapel Hill, NC

C o u n t e r - r e g u l a t o r y effects of s o d i u m b u t y r a t e o n c y t o k i n e - i n d u c e d c o m p l e m e n t (C3, C4 a n d factor B) b i o s y n t h e s i s i n h u m a n i n t e s t i n a l e p i t h e l i a l cell lines. (Abstract# G3773) A Andoh, Y Fujiyama, H Uchihara, H Sakumoto, K Hata and T Bamba. Otsu, Japan Cytokine s e c r e t i o n b y p a n c r e a t i c e p i t h e l i a l cell lines. (Abstract# G3986) J Emmrich, V Wilden, G Sparmann, M LShr and S Liebe. Rostock, Germany A n t i g e n p r e s e n t a t i o n capabilities of p r i m a r y r o u t i n e colonic epithelial cells. (Abstract# G3805) DC Baumgart, JL Rombeau and SR Carding. Philadelphia, PA

Analysis of i n t e r l e u k i n - 1 0 gene e x p r e s s i o n i n a n i n vitro model of e n t e r o c y t e d i f f e r e n t i a t i o n u s i n g CaCo-2 cells. (Abstract# G4556) GE Wild, J Hasan, MJ Ropeleski, J McCann and ABR Thomson. Montreal and Edmonton, Canada

Lipopolysaccharide s t i m u l a t e s c y t o k i n e p r o d u c t i o n b y m o u s e g a l l b l a d d e r e p i t h e l i a l cells. (Abstract# G4411) CE Savard, TA Blinman, SJ Pandol and SP Lee. Seattle, WA and Los Angeles, CA

H u m a n i n t e s t i n a l e p i t h e l i a l cells e n h a n c e apoptosis of i n t r a e p i t h e l i a l lymphocytes by soluble factors. (Abstract# G4371) W Reindl, M Classen and N Endres. Munich, Germany

B u t y r a t e a n d glucose m e t a b o l i s m b y colonocytes i n d e x t r a n s u l f a t e - i n d u c e d colitis i n mice. (Abstract# G3762) MS Ahmed, S Krishnan, BS Ramakrishna and S Murthy. Vellore, India and Philadelphia, PA

C h a r a c t e r i z a t i o n of the 5'-flanking r e g i o n of the gene for the r o u t i n e p o l y m e r i c receptor. (Abstract# G4232) MG Martin, J Wang, TWH Li, JT Lain, EM Gutierrez, RS Solorzano V and HV Tsai. Los Angeles, CA

IMMUNOLOGY, MICROBIOLOGY, AND INFLAMMATORY DISORDERS - - MUCOSAL INFLAMMATION AND HOST D E F E N S E

E x p r e s s i o n of t h e c o s t i m u l a t o r y molecules CD58, CD80 a n d CD86 o n h u m a n i n t e s t i n a l epithelial cells. (Abstract# G4010) P Framson, L Lee and R Hershberg. Seattle, WA I n t e r f e r o n g a m m a d o w n r e g u l a t e s IL-8 secretion from p r i m a r y h u m a n colonic e p i t h e l i a l cells. (Abstract# G4382) G Rogler, D V0gl, W Falk, V Gross, J SchSlmerich and T Andus. Regensburg, Germany The i n d u c t i o n of the s e c r e t i o n of IL-8 i n p r i m a r y h u m a n colonic i n t e s t i n a l e p i t h e l i a l cells is m e d i a t e d b y NF-KB. (Abstract# G4384) G Rogler, D Vogl, W Falk, V Gross, J Sch01merich and T Andus. Regensburg, Germany IL-8 gene r e g u l a t i o n i n r o t a v i r u s - i n f e c t e d i n t e s t i n a l e p i t h e l i a l cells. (Abstract# G3886) A Casola, RP Gar0falo, PL Ogra, SE Crawford, MK Estes, AR Brasier and SE Crowe. Galveston and Houston, TX Intracellular interleukin-1 receptor antagonist in i n t e s t i n a l e p i t h e l i a l cells c a n be r e g u l a t e d b y p r o i n f l a m m a t o r y s t i m u l i a n d pharmacologic agents. (Abstract# G4061) DS Han, C Jobin, L Holt, U Bocker and RB Sartor. Chapel Hill, NC C D l d b i o s y n t h e t i c p a t h w a y i n a t r a n s f e c t e d T84 cell line. (Abstract# G4133) HS Kim, R Hershberg, SP Balk and RS Blumberg. Boston, MA and Seattle, WA

I n s l t u e x p r e s s i o n of c o m p l e m e n t C3 a n d factor B genes i n n o r m a l colorectal mucosa, a d e n o m a s a n d c a r c i n o m a s . (Abstract# G3772) A Andoh, Y Fujiyama, H Sakumoto, H Uchihara, T Kimura and T Bamba. Otsu, Japan

D D W Poster Of Distinction: Cytochalasin-B m o d u l a t i o n of i n t e s t i n a l epithelial tight j u n c t i o n is m e d i a t e d by m y o s i n l i g h t c h a i n kinase. (Abstract# G4212) TY Ma, V Bui, S Mills, A Pedram and D Tran. Long Beach and Irvine, CA H u m a n colonic s u b e p i t h e l i a l myofibroblasts e n h a n c e e p i t h e l i a l r e s t i t u t i o n . (Abstract# (]4244) B McKaig, S Makh, CJ Hawkey, DK P0dolsky and YR Mahida. Nottingham, United Kingdom and Boston, MA Localization of e n d o g e n o u s SLPI to the i n t e s t i n a l epithelium: i m p l i c a t i o n s of its i m m u n o m o d u l a t o r y role i n m a i n t a i n i n g n o r m a l gut i m m u n e function. (Abstract# G4065) DM Hayden, J Woraratanadharm, MS Le and TT Pizarro. Charlottesville, VA E a r l y i n t r a c e l l u l a r s i g n a l l i n g of Clostridium d i ~ c i l e t o x i n A i n r a t i l e u m involves a p r o t e i n t y r o s i n e kinased e p e n d e n t p a t h w a y . (Abstract# G3888) I Castagliuolo, L Valenick, GJ Previte, A Pasha, CC Wang, CP Kelly, JT LaMont and C Pothoulakis. Boston, MA Role of e n d o g e n o u s glucocorticoids o n Clostridium dit~eile t o x i n A e n t e r i t i s . (Abstract# G3890) I Castagliuolo, K Karalis, A Pasha, L Valenick and C Pothoulakis. Boston, MA I n t e s t i n a l e p i t h e l i a l cell f u n c t i o n s a n d s t r u c t u r a l i n t e g r i t y i n i r r a d i a t e d r h e s u s m o n k e y s . (Abstract# G3992)

A Fasan0, TJ MacVittie, S Srinivas, K Margaretten and RM Vigneulle. Baltimore, MD IL-8 s t i m u l a t e s MAC-l-mediated n e u t r o p h i l a d h e s i o n t h r o u g h a MAP k i n a s e - d e p e n d e n t p a t h w a y . (Abstract# G4489) M Takami, R Herrera and L Petruzzelli. Ann Arbor, MI

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i[ I s o l a t i o n a n d c h a r a c t e r i z a t i o n of a n e n t e r i c ~-defensin p e p t i d e from colonic mucosa. (Abstract# G3817) C Bevins, D Ghosh, D Wflk, Y Yu and A Parmiter. Cleveland, OH Differential e x p r e s s i o n of FCT-receptor-mediated e o s i n o p h i l a c t i v i t y i n C r o h n ' s disease a n d u l c e r a t i v e colitis. (Abstract# G4364) M Raithel, S Winterkamp, J Hochberger and EG Hahn. Erlangen-Nuremberg, Germany C h a r a c t e r i z a t i o n of m u c o s a l gene expression i n i n f l a m m a t o r y bowel disease b y direct h y b r i d i z a t i o n to massively p a r a l l e l o l i g o n u c l e o t i d e arrays. (Abstract# G3954) B Dieckgraefe, W Stenson, P Swanson, C Harrington and M Mamadeu. St Louis, MO and Santa Clara, CA A novel m e t a b o l i z i n g system for low m o l e c u l a r weight thiols i n the colonic mucosa. (Abstract# G4018) J Fume, FL Suarez, EG DeMaster, J Springfield and MD Levitt. Minneapolis, MN H u m a n r e c o m b i n a n t i n t e r l e u k i n - l l protects h a m s t e r a n d h u m a n colonic m u c o s a from C. diflicHe t o x i n A a n d B effects. (Abstract# G4513) L Valenick, I Castagliuol0, M Riegler, TC O'Brien, JB Matthews, JT LaM0nt and C P0th0ulakis. Boston, MA The role of LFA-1 i n T cell a c t i v a t i o n c a n n o t be c o m p e n s a t e d for b y e n h a n c i n g T cell r e c e p t o r e n g a g e m e n t . (Abstract# G3759) C Abraham, J Griffith and J Miller. Chicago, IL P r o i n f l a m m a t o r y c y t o k i n e s differentially affect m u c i n expression i n LS180 cells. (Abstract# G3987) M-L Enss, R Eisenbl~tter, M Henrichs, S Wagner, M Cornberg, W Beil and HJ Hedrich. Hannover, Germany P o l a p r e z i n c , a p o t e n t a n t i - u l c e r agent, suppresses p r o i n f l a m m a t o r y c y t o k i n e - i n d u c e d NF-KB a c t i v a t i o n a n d i n t e r l e u k i n - 8 e x p r e s s i o n i n gastric epithelial cells. (Abstract# G4439) T Shimada, N Watanabe, M End0h, Y Ohtsuka, H Hiraishi and A Terano. Tochigi, Japan

I m p r o v e m e n t of colonic b a r r i e r f u n c t i o n b y colonization w i t h lactobacilli i n t h e rat. (Abstract# G4026) A Garcia-Lafuente, M Antolin, E Crespo, F Guarner and JR Malagelada. Barcelona, Spain A l t e r n a t i o n of d e c a y - a c c e l e r a t i n g factor e x p r e s s i o n o n g u i n e a pig gastric m u c o s a after i s c h e m i a r e p e r f u s i o n . (Abstract# G4325) T Oshima, T Joh, K Seno, M Ikai, M Sasaki, H Kataoka, Y Yok0yama, M Nonaka, N Okada, H Okada, T Tada and M Itoh. Nagoya, Japan MAC-1 (CDUb/CD18)-dependent n e u t r o p h f l a d h e s i o n to i n t e s t i n a l epithelial cells. (Abstract# G4260) R Miyata, K Iwahuchi, T Mural, S Watanahe, I Naga0ka and N Sato. Tokyo, Japan IMMUNOLOGY, MICROBIOLOGY, AND INFLAMMATORY DISORDERS - - IBD: CYTOKINES

DDW Poster of Distinction: Role of interleukin-18 i n a m u r i n e model of d e x t r a n sulfate s o d i u m - i n d u c e d colitis. (Abstract# G4258) K Mitsuyama, M Ide, T Nishiyama, N Tomiyasu, A Shirachi, T Saiki, H Tateishi, A Toyonaga, M Kurimoto, H Okamura and K Tanikawa Kurume, Fujisaki and Nishinomiya, Japan

DDW Poster of Distinction: Interleukin-15 activity a n d its m o d u l a t o r y effects o n local i m m u n e cells i n p a t i e n t s w i t h i n f l a m m a t o r y bowel disease. (Abstract# G4161) K Kusugami, T Sakai, K Ina, T Ando, M Noshiro, M Shimada and Y Yoshikai. Nagoya, Japan

DDW Poster of Distinction: The r e s p o n s e of IL-l~-converting enzyme-deficient mice to d e x t r a n sulfate. (Abstract# G4283) S Murthy, H Y0shitake, A Flanigan and S Banerjee. Philadelphia, PA and Worcester, MA

DDW Poster of Distinction:

The colonic m u c u s b a r r i e r a n d changes i n i n f l a m m a t o r y bowel disease. (Abstract# G4468) V Strugala, N Jordan, JP Pearson and A Allen. Newcastle upon Tyne, United Kingdom

Interleukin-10 attenuates epithelial invasion by Salmonella dublin a n d r e d u c e s epithelial b a r r i e r i n t e g r i t y d i s r u p t i o n . (Abstract# G4216) KL Madsen, MM Tavernini, WK MacNaughton and RN Fedorak. Calgary, Canada

I n f l u e n c e of c h r o n i c i n g e s t i o n of n i t r a t e s a n d n i t r i t e s o n g a s t r o i n t e s t i n a l n e u t r o p h i l s a n d m a s t cells i n rats. (Abstract# G3777) P Anton, V Theodorou, R Garcia-Villar, P Marche, L Ressayre, J Fioramonti and L Bu~no. Toulouse, France

Interleukin-10 genotype a n d s u s c e p t i b i l i t y to i n f l a m m a t o r y bowel disease. (Abstract# G4488) A Tagore, WM Gonsalkorale, PJ Whorwell, PJ Sinnott and IV Hutchinson. Manchester, United Kingdom

5-aminosalicylic acid b u t n o t i m m u n o s u p p r e s s i v e t h e r a p i e s p r e v e n t o x i d a n t - m e d i a t e d i n h i b i t i o n of glyceraldehyde-3-phosphate dehydrogenase. (Abstract# G4245) SM McKenzie, WF Doe and GD Buffmton. Canberra, Australia

HelicobacterpylorJ- a n d NSAID-induced gastric a n d d u o d e n a l ulcers a r e a s s o c i a t e d with p o l y m o r p h i s m s of the TNF genes. (Abstract# G4169) A Lanas, MA Garcia, JBA Crusius, S Santolaria, MT Serran0 and AS Pefia. Barcelona, Spain and Amsterdam, The Netherlands Mucosal levels of specific IgA antibodies, toxinogenicity of Helicobacterpylorl a n d gastric i n f l a m m a t i o n . (Abstract# G4597) QB Zhang, JB Dawodu, G Etolhi, CG Gemmell and RI Russell. Glasgow, Scotland

TNFa c o n v e r t i n g enzyme mRNA e x p r e s s i o n i n colonic mucosal specimens from p a t i e n t s with IBD. (Abstract# G4004) P F0egh, T Saermark, A Bingham and J Brynskov. Copenhagen, Denmark and Cambridge, United Kingdom Mucosal IL-18 mRNA is i n c r e a s e d i n C r o h n ' s disease b u t n o t u l c e r a t i v e colitis. (Abstract# G4278) GE Mullin, R Cerchia, C Werner, T Bui, GM Reddy, J Procaccino and MJ McKinley. Manhasset, NY Crohn's disease a n t i g e n p r e s e n t i n g cells i n d u c e i n c r e a s e d IFN-7 versus u l c e r a t i v e colitis. (Abstract# G4277) GE Mullin, J Costable, R Cerchia, T Bui, L Stiel, C Werner, J Procaccino, C Chang and M Chang. Manhasset, NY

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PROGRAM OF THE ANNUAL MEETING P231

A G A P O S T E R S E S S I O N m W E D N E S D A Y , MAY 20, 1998

Allele 2 of the i n t e r l e u k i n - 1 r e c e p t o r a n t a g o n i s t gene p o l y m o r p h i s m is associated w i t h r e d u c e d expression of i n t e r l e u k i n - 1 r e c e p t o r a n t a g o n i s t i n u l c e r a t i v e colitis. (Abstract# G3882) MJ Carter, S Jones, FS di Giovine, NJ Camp, AJ Lobo and GW Duff. Sheffield, United Kingdom TGF-~s a n d t h e i r r e c e p t o r s i n f l u e n c e the outcome i n C r o h n ' s disease. (Abstract# G3959) FF di Mola, H Friess, A Scheuren, P Di Sebastian0, HU Graber, BEgger, A Zimmermann, M Korc and MW Biichler. Bern, Switzerland; Pescara, Italy and Irvine, CA Interleukin-10 inhibits interleukin-1 mediated s t i m u l a t i o n of t h e cyclooxygenase pathway. (Abstract# G4598) L Zhao, F H0maidan and R Burakoff. Mineola and Stony Brook, NY U p r e g u l a t i o n of the IL-12/STAT-4 s i g n a l i n g p a t h w a y d i s t i n g u i s h e s C r o h n ' s disease from u l c e r a t i v e colitis. (Abstract# G4299) MF Neurath, I Fuss, G Schfirmann, S Pettersson; C Herfarth, H M(iller-Lobeck, K-H Meyer zum Buschenfelde and W Strober. Mainz, Muenster and Heidelberg, Germany; Bethesda, MD and Huddinge, Sweden Altered colonic s y n t h e s i s of i n t e r l e u k i n - 1 3 a n d -15 i n u l c e r a t i v e colitis a n d C r o h n ' s disease. (Abstract# G4511) B Vainer, OH Nielsen, J Hendel, T Horn and I Kirman. Copenhagen, Denmark and New York, NY I n c r e a s e d s e r u m levels of v a s c u l a r endothelial growth factor i n p a t i e n t s w i t h i n f l a m m a t o r y bowel disease. (Abstract# G4050) T Griga, A Winse, A Tromm and B May. Bochum, Germany R e d u c t i o n i n p r o i n f l a m m a t o r y cytokines expression b y NO s y n t h a s e i n h i b i t i o n i n colitis of HLA-B27 t r a n s g e n i c rats. (Abstract# G4167) D Lamarque, Z Szepes, C Bernardeau, JF Flejou, JC Delchier, BJR Whittle and M Breban. Creteil, Paris and Clichy, France; London, United Kingdom NO s y n t h a s e i n h i b i t i o n , b u t n o t corticosteroid, r e d u c e s m u c o s a l u l c e r a t i o n i n s p o n t a n e o u s colitis of HLA-B27 rats. (Abstract# G4166) D Lamarque, Z Szepes, H Blanchard, C Bernardeau, JF Flejou, JC Delchier, BJR Whittle and M Breban. Clichy, France and London, United Kingdom I n c r e a s e d e x p r e s s i o n of the c h e m o k i n e s MCP-1 a n d eotaxin within the muscularis externa during intestinal i n f l a m m a t i o n . (Abstract# G3944) Y Deng, BA Vallance, CM Hogaboam and SM Collins. Hamilton, Canada and Ann Arbor, MI T cell a c t i v a t i o n a n d d i f f e r e n t i a t i o n are r e g u l a t e d b y TNF d u r i n g m u r i n e DBA/2-~B6D2F1 graft-versus-host disease, (Abstract# G3867) G Brown and D Thiele. Dallas, TX alpha-4~7 c o s t i m u l a t i o n e n h a n c e s TNF-a release b y p e r i p h e r a l blood m o n o n u c l e a r cells. (Abstract# G4495) PD Thomas, J Meenan, HJ Ellis, A Forbes, RJ Nicholls, DJ Ringler and PJ Ciclitira. London, United Kingdom and USA

IL-1 i n c r e a s e s c e r a m i d e p r o d u c t i o n a n d i n d u c e s COX-2 i n i n t e s t i n a l e p i t h e l i a l cells. (Abstract# G4089) FR Homaidan, W E1-Assaad, I Chakroun, G Dbaibo and ME E1-Sabban. Beirut, Lebanon The m e c h a n i s m of i n t e r l e u k i n - 1 r e g u l a t i o n of p r o s t a g l a d i n E2 p r o d u c t i o n b y r a b b i t colonic epithelial cells. (Abstract# G4088) F Homaidan, L Zhao and R Burakoff. Mineola and Stony Brook, NY Decreased c o r t i c o s e n s i t i v i t y i n q u i e s c e n t Crohn's disease. An e x v i v o s t u d y u s i n g whole blood cell cultures. (Abstract# G4011) D Franchim0nt, E Louis, P Dupont, V Geenen and J Belaiche. Liege, Belgium D i m i n i s h e d s e n s i t i v i t y of ileal l a m i n a p r o p r i a m o n o n u c l e a r cells to t h e i n h i b i t o r y effect of IL-10 i n C r o h n ' s disease. (Abstract# G3909) S Colpaert, Z Liu, M Ade, G D'Haens, K Geboes, J Ceuppens and P Rutgeerts. Leuven, Belgium T r a n s d e r m a l n i c o t i n e decreases m u c o s a l IL-8 e x p r e s s i o n b u t has n o effect o n m u c i n gene expression i n u l c e r a t i v e colitis. (Abstract# G4209) B Louvet~ MP Buisine, P Desreumaux, WJ Tremaine, JP Aubert, N Porchet, JF Colombel and WJ Sandborn. Lille, France and Rochester, MN Has t h e m e s e n t e r i c t i s s u e a n i n f l a m m a t o r y role i n Crohn's disease? (Abstract# G3946) P Desreumaux, K Geboes, L Gambiez, S Hafraoui, N Ectors, A Cortot, J Auwerx, M Capron and JF Colombel. Lille, France and Leuven, Belgium C o m p a r a b l e e x p r e s s i o n of MMP-1 a n d -2 i n pouchitis a n d u l c e r a t i v e colitis. (Abstract# G4462) A StaUmach, CC Chan, S Weg-Remers, C Moser, K-W Ecker, D Schuppan and M Zeitz. Homburg, Germany I n c r e a s e i n TGF-~I levels i n r e s p o n s e to a n t i i n f l a m m a t o r y t h e r a p y i n u l c e r a t i v e colitis. (Abstract# G3835) L Boerr, A Sambuelli, E Sugay, D Felstiner, S Negreira, A Gil, G Camartino, A Tortes, S Huernos, Z Kogan, A Cavanne, A Graziano, O Bosisio, M Lumi, J Masciangelli, H Gualdrini, A Gutierrez, J Valet0, A Cavanne, Saut6, O Gonzalez, I D01ddn and R Diez. Buenos Aires, Argentina Analysis of cytokine p r o d u c t i o n b y l a m i n a p r o p r i a a n d m e s e n t e r i c l y m p h n o d e cells d u r i n g d e x t r a n sodium s u l f a t e - i n d u c e d colitis mice. (Abstract# G4171) T Le, JL Viney, JM O'Malley and B Gliniak. Seattle, WA S e q u e n t i a l expression of t r a n s f o r m i n g g r o w t h factor~1, t r a n s f o r m i n g g r o w t h factor-~3 a n d t r a n s f o r m i n g g r o w t h factor-a i n p a t i e n t s w i t h C r o h n ' s disease. (Abstract# G3988) H Ernst, U Hoffmann, J Eisenach, S Wedel, M Dietl, S Schreiber, H Lochs and the IL-10 study group. Berlin, Germany Differential effect of IL-4, IL-10 a n d IL-13 o n the p r o d u c t i o n of IL-8 a n d n i t r i c oxide i n colonic biopsies from p a t i e n t s with colitis. (Abstract# G4188) JD Linehan, JB Leithead, DA Robertson and J Westwick. Bath, United Kingdom CXC a n d CC c h e m o k i n e e x p r e s s i o n i n u l c e r a t i v e colitis.

Hepatocyte g r o w t h factor s e r u m a n d p l a s m a levels a r e elevated i n p a t i e n t s w i t h i n f l a m m a t o r y bowel disease. (Abstract# G4470) A Sturm, R Schatton, C Schulte, A Becker, H Goebell and AU Dignass. Essen, Germany

(Abstract# G4376) F Rizzello, P Gionchetti, A Venturi, M Uguccioni, D Robbiani, S Peruzzo, C Belloli, M Baggiolini and M Campieri. Bologna, Italy and Bern, Switzerland

P232PROGRAMOF THEANNUALMEETING

GASTROENTEROLOGYVol. 114~No. 4

A G A P O S T E R S E S S I O N m W E D N E S D A Y , M A Y 20, 1998 In vivo c h a n g e s of l y m p h o c y t e s u b p o p u l a t i o n s a n d leukocyte s u r f a c e m a r k e r s b y m u l t i p l e doses of recombinant h u m a n interleukin-10 in inflammatory bowel disease. (Abstract# G3939) C Dejaco, C Lichtenberger, W Reinisch, I Kuhn, H Tilg and C Gasche. Vienna and Innsbruck, Austria EMAP 2: a n o v e l p r o i n f l a m m a t o r y c y t o k i n e i n i n f l a m m a t o r y bowel disease. (Abstract# G4112) D Jenkins, K Morrell, D Powe, MPR Tas, W Sack and JC Murray. Nottingham, United Kingdom IMMUNOLOGY, MICROBIOLOGY, AND INFLAMMATORY DISORDERS w IBD: THERAPEUTICS

DDW Poster of Distinction: I n t e s t i n a l l u m e n a n d t i s s u e p h a r m a c o k i n e t i c s of m e t h o t r e x a t e i n i n f l a m m a t o r y bowel disease: s u b c u t a n e o u s m e t h o t r e x a t e achieves p h a r m a c o l o g i c a l l y active c o n c e n t r a t i o n s i n the r e c t u m . (Abstract# G3980) LJ Egan, WJ Sandborn, WJ Tremaine and JJ Lipsky. Rochester, MN Mega-analysis II: t r e a t m e n t m o d a l i t i e s i n u l c e r a t i v e proctitis. (Abstract# G3908) RD Cohen, DM Woseth and SB Hanauer. Chicago, IL Mega-analysis I: t r e a t m e n t modalities i n left-sided u l c e r a t i v e colitis. (Abstract# G3907) RD Cohen, DM Woseth and SB Hanauer. Chicago, IL C R H test p r i o r to d i s c o n t i n u a t i o n of long t e r m low-dose

glucocorticoid t h e r a p y . (Abstract# G4035) R Gellner, M Stange, U Schiemann, W Domschke and K Hengst. Muenster, Germany Toxicities a n d i n f e c t i o n s associated with c h r o n i c 6m e r c a p t o p u r i n e use i n C r o h n ' s disease: do we n e e d to d i s c o n t i n u e t r e a t m e n t ? (Abstract# G4042) ES Goldstein, JF Marion, S Wheeler and DH Present. New York, NY 6 - m e r c a p t o p u r i n e : does it i n c r e a s e or decrease t h e risks of colon c a n c e r i n C r o h n ' s disease? (Abstract# G4041) ES Goldstein, JF Marion, S Wheeler and DH Present. New York, NY Medical t h e r a p y , n o t surgery, is the a p p r o p r i a t e first line t r e a t m e n t for C r o h n ' s e n t e r o v e s i c a l fistula. (Abstract# G4555) SC Wheeler, JF Marion and DH Present. New York, NY A z a t h i o p r i n e i n i n f l a m m a t o r y bowel disease. An 8-year s t u d y a n d a s s e s s m e n t of r e s p o n s e predictors. (Abstract# G3964) E Dom~nech, X Aldegner, E Cabr~, R Vega, M Esteve, F Fernfindez-Bafiares, X Bertr~n, R Planas, J Boix and MA GassLdl. Badalona, Spain

DDW Poster of Distinction: Effectiveness of c y c l o s p o r i n A i n the t r e a t m e n t of active r e f r a c t o r y u l c e r a t i v e colitis. (Abstract# G4484) F Svanoni, U Bonassi, F Bagnolo and S Caporuscio. Bergamo, Italy

Anti-TNF-a m o n o c l o n a l a n t i b o d y (cA2) p r o d u c e s endoscopic h e a l i n g i n p a t i e n t s w i t h t r e a t m e n t r e s i s t a n t , active C r o h n ' s disease. (Abstract# G3951) GR D'Haens, SJH van Deventer, R Van Hogezand, DM Chalmers, TAJ Braakman, TF Schaible and PJ Rutgeerts. Leuven, Belgium; Amsterdam and Leiden, The Netherlands; Leeds, United Kingdom and Malvern, PA Safety a n d t o l e r a n c e of rHuIL-10 t r e a t m e n t i n p a t i e n t s w i t h mild/moderate active u l c e r a t i v e colitis. (Abstract# G4424) S Schreiber, RN Fedorak, G Wild, A Gangl, S Targan, M Jacyna, JP Wright, A Kilian, M Cohard, A Lebeaut, WJ Tremaine and Ulcerative Colitis IL-10 Cooperative Study Group. Berlin, Germany; Edmonton and Montreal, Canada; Vienna, Austria; Los Angeles, CA; Harrow, United Kingdom; Cape Town, South Africa; Kenilworth, NJ and Rochester, MD R e c o m b i n a n t h u m a n i n t e r l e u k i n - 1 0 t h e r a p y i n steroidr e f r a c t o r y c h r o n i c active Crohn's disease: i n d u c t i o n of e n o p t e r i n , a d e g r a d a t i o n p r o d u c t of t h e p t e r i d i n e p a t h w a y r e g u l a t e d b y i n t e r f e r o n - g a m m a . (Abstract# G4500) H Tilg, A Kaser, A Propst, S Schreiber, M Gregor, P Rutgeerts, S van Deventer, C Gasche, JC Koningsberger, L Abreu, B Duclos, RA van Hogezand, A Lebeaut, P Grint and G Weiss. Innsbruck and Vienna, Austria; Berlin and Tuebingen, Germany; Leuven, Belgium; Amsterdam, Utrecht and Leiden, The Netherlands; Madrid, Spain; Strasbourg, France and Kenilworth, NJ Safety, t o l e r a n c e a n d efficacy of m u l t i p l e doses of s u b c u t a n e o u s i n t e r l e u k i n - 1 0 i n m i l d to m o d e r a t e active Crohn's disease. (Abstract# G3993) RN Fedorak, A Gangl, CO Elson, P Rutgeerts, S Schreiber, G Wild, S Hanauer, SJH van Deventer, P Grint and the ILl0 IBD Cooperative Study Group. Edmonton and Montreal, Canada; Vienna, Austria; Birmingham, AL; Belgium; Germany; Chicago, IL; The Netherlands and Temple, TX Additive factor XIII t r e a t m e n t for severe u l c e r a t i v e colitis. A d o u b l e - b l i n d placebo-controlled trial. (Abstract# G4152) W Kruis, H Malchow, M Behnke, J Emmrich, J H~mling and R Lorenz. Cologne, Leverkusen, Rostock, Hamburg and Munich, Germany A c o m p a r i s o n of two different doses of balsalszide a n d one dose of m e s a l a z i n e i n c h r o n i c t r e a t m e n t of u l c e r a t i v e colitis. (Abstract# G4151) W Kruis. Cologne, Germany Clinical efficacy of a d d i t i o n a l FXIII t r e a t m e n t i n steroid r e f r a c t o r y p a t i e n t s with u l c e r a t i v e colitis. (Abstract# G3857) N Bregenzer, I Caesar, T Andus, H Malchow, S Schreiber, J Sch~lmerich and the Factor XIII Study Group. Regensburg, Germany I n t r a v e n o u s cyclosporine for r e f r a c t o r y attacks of Crohn's disease: long t e r m follow-up of p a t i e n t s . (Abstract# G4178) M L~mann, F G~rard de La Valussie, Y Bouhnik, M Allez, Y Touze, J Bonnet, B Coffin, C Matuchansky, R Jian, JF Colombel, JC Rambaud and R Modigliani. Paris and Lille, France C o m p a r i s o n of a z a t h i o p r i n e (AZA) a n d 6m e r c a p t o p u r i n e p l a s m a c o n c e n t r a t i o n s after a d m i n i s t r a t i o n of AZA s o l u t i o n i n t o t h e stomach, j e j u n u m , or cecum. (Abstract# G4036) J Gervasio, M Tabba, J Lima, T Abell, R Werkman, R Brown, L Haberer, ALum and L Hak. Memphis, TN

P R O G R A M O F THE ANNUAL MEETING P233

April 1998

A G A P O S T E R S E S S I O N m W N D N N S D A Y , M A Y 20, 1 9 9 8 Effect of food o n b u d e s o n i d e p h a r m a c o k i n e t i c s i n p a t i e n t s w i t h active C r o h n ' s disease. (Abstract# G4286) THJ Naber, JBMJ Jansen, S Cvetkovic, S Edsb~cker and T Persson. Nijmegen, The Netherlands and Lund, Sweden

Low m o l e c u l a r weight h e p a r i n as a d j u v a n t t h e r a p y i n u l c e r a t i v e colitis. (Abstract# G4502) L T~rkvist, H Thorlacius, A Lapidus, U SjSqvist, L Flood, B Agren, A Ost, J Raud and R LSfberg. Stockholm, Sweden

R e s t o r a t i o n of m u s c l e s t r e n g t h after n u t r i t i o n a l s u p p l e m e n t a t i o n i n p a t i e n t s w i t h Crohn's disease i n a d o u b l e - b l i n d placebo-controlled study. (Abstract# G4032) BJ Geerling, C van Deursen, RW St0ckbriigger and RJM Brummer. Maastricht and Brunssum, The Netherlands

O p t i m i z i n g gene t r a n s f e r to t h e i n t e s t i n e , a c o m p a r i s o n of t h r e e different t e c h n i q u e s . (Abstract# G4363) N Radojevic, BA Vallance and SM Collins. Hamilton, Canada

A r a n d o m i z e d t r i a l c o m p a r i n g the efficacy a n d t o l e r a n c e of classical a n d slow release 5-ASA s u p p o s i t o r i e s to t r e a t a c u t e attacks o f u l c e r a t i v e proctitis. (Abstract# G4003) C Florent, P Marteau and the French Pentasa study group. Paris, France The facilitative role of epithelial b a r r i e r d i s r u p t i o n i n successful gene t r a n s f e r to t h e colon. (Abstract# G4517) BA Vallance, N Radojevic, G Barbara, F Galeazzi, FL Graham, J Gauldie and SM Collins. Hamilton, Canada Selection of a p r o b i o t i c s t r a i n to modify h u m a n gut flora a n d a c o n t r o l l e d t r i a l of delivery a n d efficacy. (Abstract# G4274) D Morrisey, L Murphy, P Marteau, B Kiely, G Fitzgerald, C Daly, G O'Sullivan, F Shanahan and JK Collins. Cork, Ireland and Paris, France A n t i s e n s e to ICAM-1 affects the p e r i p h e r a l blood e x p r e s s i o n a n d i n t e s t i n a l e x p r e s s i o n of a d h e s i o n molecules i n C r o h n ' s disease. (Abstract# G3851) MB Bowen-Yacyshyn, W Shanahan, F Bennett, J Tami, M Gallatin, B Rothlein, E Mainolfi, L Jewell and BR Yacyshyn. Edmonton, Canada; Carlsbad, CA; Bothell, WA and Ridgefield, CT

B u t y r a t e a n d c a p r o a t e e n h a n c e colonic w o u n d r e p a i r a n d m o d u l a t e the e x p r e s s i o n of PCNA a n d cyclin D i n colonic m u c o s a of rats w i t h TNBS colitis. (Abstract# G4572) JH Xing, HM Blotti~re, A Jarry, JP Segain, C Cherbut, C Laboisse and JP Galmiche~ Nantes, France Cyclosporin A has s u p p r e s s i v e effects on n e u t r o p h i l s a n d mucosal T cells. (Abstract# G4103) K Ina, K Kusugami, T Ando, T Hosokawa, A Imada, M Ohsuga and M Shimada. Nagoya, Japan Lidocaine e n e m a s for i n t r a c t a b l e distal u l c e r a t i v e colitis: efficacy a n d safety. (Abstract# G4395) FG Saibil. Toronto, Canada P h a r m a c o g e n e t i c s of 5-ASA m e t a b o l i s m i n I B D patients: p r e l i m i n a r y r e p o r t of v a r i a t i o n i n Na c e t y l t r a n s f e r a s e 1 gene p o l y m o r p h i s m s a n d 5-ASA m e t a b o l i s m r a t e s i n m u c o s a l biopsies. (Abstract# G3972) J Easterbrook, G Armstrong, TM Bayless, ML Harris and MH Montrose. Baltimore, MD HORMONES, TRANSMITTERS, GROWTH FACTORS AND T H E I R RECEPTORS - - BIOLOGY OF GROWTH FACTORS II

M a i n t e n a n c e t r e a t m e n t w i t h balsalazide provides more effective c o n t r o l of n o c t u r n a l s y m p t o m s of ulcerative colitis t h a n d e l a y e d release mesalazine. (Abstract# G4046) JRB Green, JA Gibson, GD Kerr, ET Swarbrick, CD Holdsworth, AJ Lobo, JP Crowe, KJ Schofield, MD Taylor and the ABACUS Investigator Group. Stoke, Stafford, Shrewsbury, W01verhampton, Sheffield and Kings Langley, United Kingdom; Dublin, Ireland

Glucagon-like peptide-2 r e d u c e s i n t e s t i n a l epithelial p e r m e a b i l i t y of both the p a r a c e l l u l a r a n d t r a n s c e l l u l a r pathway. (Abstract# G4620) MA Benjamin, DM McKay and MH Perdue. Hamilton, Canada

Open m a i n t e n a n c e t r e a t m e n t with t r a n s d e r m a l n i c o t i n e : l o n g t e r m r e s u l t s after a r a n d o m i z e d , doubleblind, placebo-controlled t r i a l for active u l c e r a t i v e colitis. (Abstract# G4401) WJ Sandborn, W Tremaine and RD Hurt. Rochester, MN

Overexpression of c-jun, b u t n o t c-los, s i g n i f i c a n t l y u p r e g u l a t e s p r o m o t e r a c t i v i t y of IGFBP-4 gene i n d i f f e r e n t i a t i n g CaCo-2 cells. (Abstract# G4823) Q Shen, B Dai and P Singh. Galveston, TX

S u l f a s a l a z i n e is a p o t e n t a n d specific i n h i b i t o r of n u c l e a r factor-KB activation. (Abstract# G4550) C Wahl, RM Schmid, G Adler and S Liptay. Ulm, Germany

Glucagon-like peptide-2 e n h a n c e s i n t e s t i n a l f u n c t i o n following massive small bowel resection. (Abstract# G4717) Y Kato, K Alavi, D Yu and MZ Schwartz. Wilmington, DE and Philadelphia, PA

P r o t e c t i o n of a c u t e TNBS colitis b y a n IL-2i m m u n o g l o b u l i n f u s i o n p r o t e i n i n mice. (Abstract# G4343) K Pfister, C Peters, J Hoffmann, R Duchmann, S BulfonePauss, U Kunzendorf, M Zeitz and A Stallmach. H0mburg/Saar, Berlin and Erlangen, Germany Octreotide does n o t i m p r o v e r e s p o n s e to corticosteroids i n severe u l c e r a t i v e colitis. (Abstract# G4518) JD van Bergeijk, JHP Wilson, OH Nielsen, G Adler, AL Karvonen, I Lygren, A R~idler, H Waldum, CJJ Mulder, S Friis, T Solomon and JFW Hoogkamer. Rotterdam and Arnhem, The Netherlands; Copenhagen, Denmark; Ulm and Hamburg, Germany; Tampere, Finland; Oslo, Trondheim and Bergen, Norway; Birsfelden, Switzerland

S t i m u l a t o r y a c t i o n of t r a n s f o r m i n g g r o w t h factor-a on i n t e s t i n a l p e p t i d e YY. (Abstract# G4849) V Udupi, RJ Coffey, Jr, B West, S Rajaraman and GH Greeley, Jr. Galveston, TX and Nashville, TN

R e g u l a t i o n of I G F - b i n d i n g protein-3 a n d -5 b y TGF-~I a n d IGF-I i n h u m a n i n t e s t i n a l muscle cell cultures. (Abstract# G4632) TL Bushman and JF Kuemmerle. Richmond, VA Autocrine r e g u l a t i o n of i n t e s t i n a l muscle cell growth by the e n d o g e n o u s g r o w t h factor, GDNF. (Abstract# G4732) JF Kuemmerle and TL Bushman. Richmond, VA IGF-I r a p i d l y activates m u l t i p l e signal t r a n s d u c t i o n p a t h w a y s i n r a t i n t e s t i n a l s m o o t h muscle cells. (Abstract# G4796) XP Pin, YT Hou, KN Bitar and EM Zimmermann. Ann Arbor, MI

P234PROGRAMOFTHEANNUALMEETING

GASTROENTEROLOGYCol. 114,No.4

WEDNESDAY, MAY 20, 1998 M e c h a n i s m s of l i n e a r g r o w t h f a i l u r e associated with i n t e s t i n a l i n f l a m m a t i o n . (Abstract# G4608) AB Ballinger, O Azooz and MJG Farthing. London, United Kingdom

AGA Clinical Symposium

2:15-3:45 p m

Ballroom C Ernest N. Morial Convention Center

T N F - a l p h a - i n d u c e d h u m a n i n t e s t i n a l c r y p t cell growth i n h i b i t i o n is m e d i a t e d via the p55 TNF-R1. (Abstract# G4809) FM Ruemmele, S Dionne, JF Beaulieu, E Levy and EG Seidman. Montreal and Sherbrooke, Canada

Sponsored by Immunology, Microbiology, and Inflammatory Disorders Co-sponsored by Clinical Practice

G r o w t h factor r e c e p t o r e x p r e s s i o n i n n e u r o e n d o c r i n e t u m o r s of t h e g a s t r o e n t e r o p a n c r e a t i c system. (Abstract# G4873) U Wulbrand, M Wied, P Z6fel, R Arnold, B G6ke and HC Fehmann. Marburg, Germany

P E R S P E C T I V E S ON C U R R E N T AND F U T U R E T H E R A P I E S FOR IBD

I n t e s t i n a l trefoil factor c o n t r o l s the e x p r e s s i o n of the a d e n o m a t o u s polyposis coli/catenin a n d t h e Ec a d h e r i n / c a t e n i n complexes i n h u m a n colon c a r c i n o m a cells. (Abstract# G4795) M Pignatelli, J Efstathiou, M N0da and A Jawhari. London, United Kingdom D i s t r i b u t i o n of h e a t shock p r o t e i n 70 e x p r e s s i o n i n h u m a n u p p e r g a s t r o i n t e s t i n a l t r a c t a n d small intestine. (Abstract# G4772) T Mullick, M Motevalli, S Vinayek, UK Tantry, PP Nair and SK Dutta. Baltimore and Beltsville, MD The effect of t a c r o l i m u s o n colon a n a s t o m o t i c healing. (Abstract# G4817) M Sch~ffer, J V61ker, B Proksch, M Bongartz and HD Becker. Tiibingen, Germany

DDW Poster of Distinction: G a s t r i n - r e l e a s i n g p e p t i d e m a y act as a n a u t o c r i n e g r o w t h factor i n most colorectal cancers, b u t n o t i n polyps or metastases. (Abstract# G4636) RE Carroll, KA Matkowskyj, I Cantave, S Chakrabarti, T McDonald, M Mullane and RV Benya. Chicago, IL and London, Canada E x p o s u r e to C 2 c e r a m i d e p r o t e c t s aged n e u r o n s from apoptotic d e a t h i n d u c e d b y n e r v e g r o w t h factor w i t h d r a w a l a n d t u m o r necrosis factor alpha. (Abstract# G4824) H Sheng, S Srinivasan, JW Wiley and KE Hall. Ann Arbor, MI G a s t r o i n t e s t i n a l s t r o m a l t u m o r s express e-/~'t r e c e p t o r t y r o s i n e k i n a s e : possible o r i g i n i n i n t e r s t i t i a l cells of Cajal. (Abstract# G47U) K Isozaki, S Hirota, J-I Miyagawa, M Nakahara, Y Shinomura and Y Matsuzawa. Osaka, Japan F u n c t i o n a l e x p r e s s i o n of t h e h u m a n e p i d e r m a l growth factor r e c e p t o r i n E~cher/ch/a col~ a n e w m e t h o d for a n a l y z i n g the biological activity of EGF isoforms. (Abstract# G4861) Y Wang, J Hu and S Cheng. Xi'an and Shanghai, China

Chair:

Stephen B. Hanauer

Positioning our current therapeutic armamentarium. William J. Sandborn. Rochester, MN Targets for f u t u r e t h e r a p e u t i c approaches. Bruce Sands. Boston, MA T h e r a p e u t i c n e e d s from a t r i a l i s t ' s (curmudgeon's) view. Brian G. Feagan. London, Canada AGA Clinical Symposium

2:15-3:45 p m

Room 58 /59 / 60 Ernest N. Morial Convention Center

Sponsored by Clinical Practice Chair:

Bruce A. Runyon

M A N A G E M E N T OF ASCITES Dietary a n d d i u r e t i c therapy. Florence Wong. Toronto, Canada Large v o l u m e p a r a e e n t e s i s - how to do it! Bruce A. Runyon. Loma Linda, CA Concentrate reinfusion. Lorenzo Rossaro. Albuquerque, NM TIPS - s o l u t i o n or stall? Kent G. Benner. Portland, OR Infections a n d p e r i t o n i t i s . John M. Inadomi. Albuquerque, NM Questions a n d Answers

April 1998

PROGRAMOF THEANNUALMEETINGP235

WEDNESDAY, MAY 20, 1998 Gastrointestinal Oncology AGA Research Forum

2:15-3:45pm

Room 11 Ernest N. Morial Convention Center

2:45

Bacterial genes i n m i x e d cholesterol gallstones a n d associated sludge. (Abstract# G2157) DK Lee, PI Tart, JW Choi, WG Halgh and SP Lee. Seattle, WA and W0nju, Korea

3:00

Excessive biliary cholesterol s u p e r s a t u r a t i o n r a t h e r t h a n soluble p r o n u c l e a t i n g proteins or bile salt hydrophobicity is key to high susceptibility for gallstone f o r m a t i o n i n the i n b r e d mouse: a time-course study. (Abstract# G2238) KJ van Erpecum, DQ-H Wang, F Lammert, B Paigen, AK Gr0en and MC Carey. Boston, MA; Utrecht, The Netherlands and Bar Harbor, ME

3:15

C F T R is expressed b y g a l l b l a d d e r e p i t h e l i u m : a p o t e n t i a l r e g u l a t o r of chloride a n d m u c u s s e c r e t i o n d u r i n g g a l l s t o n e formation. (Abstract# G2175) KE Morgenstern, ZR Abedin, PR Smith, AJ Moser, MZ Abedin and JJ Roslyn. Philadelphia, PA

3:30

Ursodeoxycholic acid r e d u c e s lipid peroxid a t i o n a n d m u c i n s e c r e t a g o g u e activity of h u m a n bile i n cholesterol gallstone disease. (Abstract# G2244) C von Ritter, N Sreejayan, I Mfiller, G Meyer and D Jiingst. Munich, Germany

Chairs: Patrick M. Lynch, Rosalind U. van Stolk C H E M O P R E V E N T I O N OF GI CANCER 2:15

A r a n d o m i z e d t r i a l of c a l c i u m s u p p l e m e n t a t i o n to p r e v e n t colorectal a d e n o m a s . (Abstract# G2303) JA Baron and M Beach. Hanover, NH

2:30

Non-aspirin nonsteroidal antiinflammatory d r u g use a n d colorectal cancer: a p o p u l a t i o n b a s e d s t u d y i n t h e elderly. (Abstract# G2814) W Smalley, WA Ray, J Daugherty and MR Griffin. Nashville, TN

2:45

C h e m o p r e v e n t i o n of colonic a d e n o c a r c i n o m a i n the r a t with a n a s p i r i n derivative: lack of a role for cyclooxygenase i n h i b i t i o n . (Abstract# G2299) AW Bak, W McKnight, P Li, P Del Soldato and JL Wallace. Calgary, Canada and Paris, France

3:00

S u l i n d a c sulfone (FGN-1) i n p a t i e n t s w i t h familial a d e n o m a t o u s polyposis: polyp effect a n d t o l e r a b i l i t y from a n open label e x t e n s i o n trial. (Abstract# G2882) R van Stolk, K Provancher, C Burke, J Church and R Pamukcu. Cleveland, OH and Horsham, PA

3:15

3:30

T r e a t m e n t w i t h 600 mg/day of ursodeoxycholic acid m a x i m a l l y supresses the p r o p o r t i o n of deoxycholic acid i n fecal water. (Abstract# G2413) DL Earnest, M Reid, D Heddens, AK Batta, G Salen, DS Alberts and T Morales. Newark, NJ and Tucson, AZ D i e t a r y n i t r a t e lowers gastric j u i c e ascorbic acid c o n c e n t r a t i o n s . (Abstract# G2671) C Mowat, A Carswell, S Miller and KEL McColl. Glasgow, Scotland

Hormones, Transmitters, Growth Factors and Their Receptors AGA Research Forum

2:15-3:45 p m

Chairs: Robert T. Jensen, Stephen A. Wank RECEPTOR CYCLING, I N T E R N A L I Z A T I O N AND TRAFFICKING 2:15

S u b s t a n c e P - i n d u c e d d e s e n s i t i z a t i o n of t h e n e u r o k i n i n - 1 r e c e p t o r a n d t r a f f i c k i n g of Gp r o t e i n r e c e p t o r k i n a s e s a n d ~-arrestin i n n e u r o n s . (Abstract# G4654) CU Corvera, K McConalogue, PD Gamp, EF Grady and NW Bunnett. San Francisco, CA

2:30

Substance P induces neurokinin 1 receptor endocytosis i n i n t e r s t i t i a l cells of Cajal i n g u i n e a pig small i n t e s t i n e . (Abstract# G4836) BR Southwell, ST Lavin and JB Furness. Parkville, Australia

2:45

I n t e r n a l i z a t i o n is n o t i m p o r t a n t for desensitization or r e s e n s i t i z a t i o n of the cholecystokinin type B receptor. (Abstract# G4649) J-K Choi, C Linehan, N Perin, M P0hl and SA Wank. Bethesda, MD

3:00

Secretin r e c e p t o r i n t e r n a l i z a t i o n involves a m e c h a n i s m d i s t i n c t from c l a t h r i n - c o a t e d d e p e n d e n t endocytosis. (Abstract# G4826) MA Shetzline, JKL Walker, RT Premont, SR Vigna and MG Caron. Durham, NC

3:15

A c t i v a t i o n a n d i n t e r n a l i z a t i o n of the ~-opioid r e c e p t o r by e n d o m o r p h i n - 1 a n d -2. (Abstract# G4760) K McC0nalegue, EF Grady, J Minnis, B Balestra, M Tonini, NC Brecha, NW Bunnett and C Sternini. San Francisco and Los Angeles, CA and Pavia, Italy

3:30

L i g a n d - r e g u l a t e d p-opioid r e c e p t o r endocytosis r e d u c e s t h e r e s p o n s i v e n e s s of n e u r o n s to opioids. (Abstract# G4841) C Sternini, J Minnis, B Balestra, E Fiori, NC Brecha and M Tonini. Los Angeles, CA and Pavia, Italy

Biliary Disorders AGA Research Forum

2:15-3:45pm

Room 19 Ernest N. Morial Convention Center

Chairs: Douglas M. Heuman, Junichi Shoda P A T H O G E N E S I S OF GALLSTONES 2:15

2:30

S p o n t a n e a o u s cholesterol gallstone f o r m a t i o n o n n o r m a l diet c h a r a c t e r i z e s mice with d i s r u p t e d Mdr2 P-glycoprotein gene a n d p r o v i d e s n e w i n s i g h t s i n t o cholesterol c r y s t a l l i z a t i o n a n d bile formation. (Abstract# G2151) F Lammert, DQ-H Wang, B Paigan and MC Carey. Boston, MA and Bar Harbor, ME Cholesterol gallstone g r o w t h i n model biles is i n v e r s e l y r e l a t e d to cholesterol crystal f o r m a t i o n . (Abstract# G2237) AA van den Berg, JD van Buul, GNJ Tytgat, JD Ostrow and AK Groen. Amsterdam, The Netherlands

Room 33/35 Ernest N. Morial Convention Center

P236 P R O G R A M O F T H E A N N U A L MEETING

GASTROENTEROLOGY Vol. 114~ No. 4

WEDNESDAY, MAY 20, 1998 Gastrointestinal Oncology AGA Research Forum

2:15-3:45 p m

2:45

Alkaline s p h i n g o m y e l i n a s e a c t i v i t y is m a r k e d l y decreased i n f a m i l i a l a d e n o m a t o u s polyposis a n d colorectal a d e n o m a s : a key factor to t h e u n r e s t r a i n e d cell p r o l i f e r a t i o n ? (Abstract# G2509) E Hertervig, A Nilsson, R-D Duan, J Bj6rk and R Hultkrantz. Lund and Stockholm, Sweden

3:00

D y s r e g u l a t i o n of colonic e p i t h e l i a l Fas l i g a n d expression occurs e a r l y i n t h e a d e n o m a c a r c i n o m a sequence. (Abstract# G2310) MW Bennett, J O'Connell, GC O'Sullivan, JK Collins and F Shanahan. Cork, Ireland

Room 80/81 Ernest IV. Morial Convention Center

Chairs: Harold Frucht, Pomila Singh GASTRIN AND GI N E O P L A S I A 2:15

S e r u m c h r o m o g r a n i n - A differentiates g a s t r i n o m a from n o n - n e o p l a s t i c causes of h y p e r g a s t r i n e m i a . (Abstract# G2402) S Drapkin and RRP Warner. New York, NY

3:15

2:30

Gastrin-mediated alterations i n gastric epithelial apoptosis a n d proliferation i n a rodent model of gastric neoplasia. (Abstract# G2557) M Kidd, SF Moss, LH Tang, T Zhang, K Chin, P H01t and IM Modlin. New Haven, CT and New York, NY

S e q u e n t i a l a n d selective a c t i v a t i o n of caspases d u r i n g d e t a c h m e n t - i n d u c e d apoptosis of h u m a n i n t e s t i n a l e p i t h e l i a l cells. (Abstract# G2477) J Grossmann, C Fiocchi and AD Levine. Cleveland, OH

3:30

2:45

Effect of g a s t r i n n e u t r a l i s a t i o n o n the p r o g r e s s i o n of t h e a d e n o m a : c a r c i n o m a s e q u e n c e i n t h e / h r / N m o u s e model of familial a d e n o m a t o u s polyposis. (Abstract# G2900) SA Watson, AM Smith, C Parasceva, D Michaeli and JD Hardcastle. Nottingham and Bristol, United Kingdom; CA

Changes i n signal t r a n s d u c t i o n r e s u l t i n g from focal a d h e s i o n k i n a s e cleavage d u r i n g apoptosis of h u m a n i n t e s t i n a l e p i t h e l i a l cells. (Abstract# G2476) J Grossmann, AW Grasso, C Fiocchi and AD Levine. Cleveland, OH

3:00

3:15

3:30

T u m o r i g e n i c i t y of a h u m a n colon c a n c e r cell lines is s i g n i f i c a n t l y r e d u c e d , in vivo, i n the p r e s e n c e of colon c a n c e r cells o v e r e x p r e s s i n g a n t i s e n s e g a s t r i n mRNA: role of i n h i b i t o r y (endocrine) factors i n t h e observed b y s t a n d e r effects. (Abstract# G2811) P Singh and A Owlia. Galveston, TX L y m p h o c y t e e x p r e s s i o n of the CCK-B/gastrin r e c e p t o r i n gastric l y m p h o m a s , Hellcobacter pylori g a s t r i t i s a n d n o r m a l gastric biopsies. (Abstract# G2333) BT Brett, K Savage, K Khan, D Michaeli, AP Dhfllon, RE Pounder and ME Caplin. London, United Kingdom and Woodland, CA A n t i b o d i e s t a r g e t i n g the a m i n o t e r m i n a l p o r t i o n of the h u m a n CCKG/gastrin receptor i n h i b i t the liver i n v a s i o n of a h u m a n colonic t u r n o u t . (Abstract# G2899) SA Watson, AM Smith, D Michaeli, S Grimes, M Caplin and JD Hardcastle. Nottingham and Bristol, United Kingdom; CA

Esophageal, Gastric, and Duodenal Disorders AGA Research Forum

2:15-3:45 p m

Chairs: Roy C. Orlando, David A. Katzka PATHOPHYSIOLOGY OF G A S T R O E S O P H A G E A L R E F L U X DISEASE 2:15

I n t r a l u m i n a l acid perfusion causes esophageal s h o r t e n i n g i n h u m a n s : a c o n t r i b u t i n g factor i n the etiology of hiatial h e r n i a ? (Abstract# G0453) D Dunne and WG Paterson. Kingston, Canada

2:30

The role of the lower esophageal s p h i n c t e r a n d h i a t a l h e r n i a i n the p a t h o g e n e s i s of gastroesophageal reflux disease. (Abstract# S0206) M Fein, MP Ritter, TR DeMeester, JH Peters, S Oberg, JA Hagen and CG Bremner. Los Angeles, CA

2:45

Effects of e t h a n o l o n e s o p h a g e a l e p i t h e l i u m a n d its r e s i s t a n c e to acid i n j u r y in ~vo. (Abstract# G0317) S Bor, C Caymaz-Bor, NA Tobey, S AbdulnourNakh0ul and RC Orlando. New Orleans, LA

3:00

P o s t p r a n d i a l f u n d i c r e l a x a t i o n is i n c r e a s e d i n p a t i e n t s w i t h gastroesophageal reflux disease. (Abstract# G1410) F Zerbib, S Bruley des Varannes, A Ropert, H Lamouliatte and J Galmiche. Nantes and Bordeaux, France

3:15

A b n o r m a l cough reflex a f t e r i n h a l a t i o n of b r o n c h i a l i r r i t a n t s i n esophagitis p a t i e n t s . (Abstract# G0290) L Banini, C Sembenini, V Zuccali, M Olivieri, F Fiorino, GM Bu]ighin, A Ederle, V Lo Cascio, M Ferrari and I Vantini. Verona, Italy

3:30

I n t r a d u o d e n a l fat alters p e r c e p t u a l a n d a u t o n o m i c responses to acid p e r f u s i o n of the esophagus i n GERD p a t i e n t s . (Abstract# G0819) A Lembo, B Naliboff, J Munakata, R Fass, G Ohning and EA Mayer. Los Angeles, CA and Boston, MA

Gastrointestinal Oncology AGA Research Forum

2:15-3:45 p m

Room 82 / 83 Ernest N. Morial Convention Center

Chairs: Graeme P. Young, Michael J. Wargovich R E G U L A T I O N OF P R O L I F E R A T I O N AND APOPTOSIS IN GI CANCER 2:15

HER2/NEU o v e r e x p r e s s i o n i n t e r f e r e s with r e t i n o b l a s t o m a p r o t e i n - m e d i a t e d cell cycle regulation in h u m a n pancreatic carcinoma cells. (Abstract# S0210) H Roh, J Pippen and JA Drebin. St Louis, MO

2:30

E p i t h e l i a l h y p e r p r o l i f e r a t i o n alters ~-catenin e x p r e s s i o n a n d d i s t r i b u t i o n i n m o u s e colon. (Abstract# G2872) S Umar, C Leonard, A Morris and J Sellin. Houston, TX

Room 8 5 / 8 6 Ernest N. Morial Convention Center

April 1998

PROGRAM OF THE ANNUAL MEETING P237

WEDNESDAY, MAY 20, 1998 Esophageal, Gastric, and D u o d e n a l Disorders

2:45

A proposed b r a i n s t e m c i r c u i t r y for the receptive r e l a x a t i o n reflex. (Abstract# G3484) RA Travagli and RC Rogers. Detroit, MI and Columbus, OH

3:00

Effect of s p l a n c h n e c t o m y o n j e j u n a l m o t i l i t y a n d c-Fos e x p r e s s i o n i n b r a i n stem n u c l e i after i n t e s t i n a l a n a p h y l a x i s . (Abstract# G3428) RB Scott, DTM Tan and KA Sharkey. Calgary, Canada

3:15

A b i h e m i s p h e r i c cortical r e p r e s e n t a t i o n of the a n a l s p h i n c t e r o n h u m a n m o t o r cortex. (Abstract# G3529) K Witscher, I Greving, J Liepert, M Tegenthoff and P Enck. Bochum and Duesseldorf, Germany

3:30

F u n c t i o n a l c e r e b r a l c h a n g e s d u r i n g rectal stimulation: a functional magnetic resonance i m a g i n g s t u d y i n h e a l t h y h u m a n s . (Abstract# G3034) B Coffin, D Bouhassira, JM Sabat~, D Souli~, YS Cordoliani and R Jian. Saint-Louis and Paris, France

AGA Research Forum

2:15-3:45 p m

Room 90 / 91 / 92 Ernest N. Morial Convention Center

Chairs: Colin W. Howden, Naoki Chiba H E L I C O B A C T O R PYLORI: T H E R A P E U T I C REGIMENS 2:15

L a n s o p r a z o l e 30 m g or 60 mg c o m b i n e d w i t h two a n t i b i o t i c s (amoxicillin a n d c l a r i t h r o m y c i n ) to e r a d i c a t e Helicobaeter pylori. (Abstract# G0798) H Lamouliatte, S F0restier and F Perle. Bordeaux, France

2:30

The effectiveness a n d side effects of omeprazole, c l a r i t h r o m y c i n a n d t i n i d a z o l e u s e d i n a c o m m u n i t y HeHcobaeterpylori e r a d i c a t i o n p r o g r a m . (Abstract# G0944) P Moayyedi, D Braunholtz, J Nathan, IDG Richards, AC Dowell, S Mason and ATR Axon. Leeds, United Kingdom

2:45

P r o s p e c t i v e r a n d o m i z e d c o m p a r i s o n of r a n i t i d i n e b i s m u t h c i t r a t e versus colloidal b i s m u t h s u b - c i t r a t e b a s e d triple t h e r a p y for t h e t r e a t m e n t of H. pyzloriinfection. (Abstract# G0780) NNS Kung, JY Sung, WF Yuen, TH Li, PW Ng, WM Lai and MF Leung. Hong K0ng, China

AGA Topic Forum

3:00

Only once a day for six days: compliance effective t r i p l e - t h e r a p y a g a i n s t Helieobacter pyloridisease. (Abstract# Gl153) REA Seelis and W D0hmen. Aachen, Germany

3:15

Once-daily t h e r a p y for H. pylor~, a r a n d o m i z e d c o m p a r i s o n of four regimens. (Abstract# G0791) L Laine, R Estrada, M Trujillo, PK Cheybani, Yeramian, S Smith and G Neff. Los Angeles, CA; Chicago, IL and Wayne, PA

3:30

R i f a b u t i n - b a s e d t r e a t m e n t as "rescue t h e r a p y " f o r / / , pylori infected p a t i e n t s after failure of s t a n d a r d regimens. A pilot study. (Abstract# G1056) F Perri, V Festa, R Clemente, M Quitadamo and A Andriulli. San Giovanni Rotondo, Italy

4:00-5:30 p m

Chairs: Denis M. McCarthy, Fred Halter COX-2: BASIC M E C H A N I S M S AND CLINICAL REALITIES 4:00

COX-2 overview: basic m e c h a n i s m s . Brigitta Peskar. Bochum, Germany

4:15

COX-2 overview: clinical realities. Denis McCarthy. Albuquerque, NM

4:30

Cyclooxygenase-2-derived p r o s t a g l a n d i n s c o n t r i b u t e to m u c o s a l r e s i s t a n c e to i s c h e m i a / r e p e r f u s i o n i n j u r y i n the r a t stomach. (Abstract# G0883) N Maricic, K Ehrlich, R Schuligoi, M Respondek and BM Peskar. Bochum, Germany and Graz, Austria

4:45

Cyclooxygenase(COX)-I & -2 i n h u m a n gastric mucosa: c o n s t i t u t i v e e x p r e s s i o n b y p a r i e t a l cells a n d i n d u c t i o n of COX-2 i n l a m i n a p r o p r i a cells p r o x i m a l to ulcers. (Abstract# G1365) KC Wu, L Jackson, YR Mahida, D Jenkins and CJ Hawkey. Nottingham, United Kingdom

5:00

COX-1 e x p r e s s i o n i n h u m a n gastric m u c o s a infected w i t h Helicobacterpylori- c o n s t i t u t i v e or i n d u c e d ? (Abstract# G0653) LM Jackson, K Wu, YR Mahida, D Jenkins, MT Donnelly and CJ Hawkey. Nottingham, United Kingdom

Motility and Nerve-Gut Interactions AGA Research Forum

2:15-3:45 p m

Room 99 Ernest N. Morial Convention Center

Chairs: Emeran A. Mayer, David G. Thompson R E F L E C T I O N S OF T H E GUT IN THE BRAIN 2:15

2:30

I m p r o v e d t e c h n i q u e for s t u d y of b r a i n activity during swallowing by functional magnetic r e s o n a n c e imaging. (Abstract# G2984) RM Birn, PA Bandettini, RW Cox and R Shaker. Milwaukee, WI C o m p a r i s o n of cortical p o t e n t i a l s evoked b y m e c h a n i c a l a n d electrical s t i m u l a t i o n of the h u m a n esophagus. (Abstract# G3156) A Hobs0n, S Sarkar, Q Aziz, P Furlong, J Barlow, J Bancewicz and DG Thompson. Salford and Birmingham, United Kingdom

Room 85/86 Ernest N. Morial Convention Center

5:15

E x p r e s s i o n of cyclooxygenase-1 a n d -2 i n H.

pylori-associated gastritis. (Abstract# G1270) KF To, FKL Chan, WK Leung and JY Sung. Hong Kong, China

G A S T R O E N T E R O L O G Y Vol. 1141 No. 4

P238 P R O G R A M O F T H E A N N U A L MEETING

WEDNESDAY, MAY 20, 1998 Esophageal, Gastric, and Duodenal Disorders AGA R e s e a r c h F o r u m

4:00-5:30 p m

4:15

I n c r e a s e d m u c o s a l m a s t cells i n i r r i t a b l e bowel s y n d r o m e . (Abstract# G3352) M O'Sullivan, NP Breslin, I Harman, N Clayton, C Bountra, A McLaren and CA O'Morain. Dublin, Ireland and Stevenage, United Kingdom

4:30

On t h e m e c h a n i s m u n d e r l y i n g p o s t - i n f e c t i v e i n t e s t i n a l d y s f u n c t i o n . (Abstract# G2966) G Barbara, PA Blennerhassett and SM Collins. Hamilton, Canada

4:45

A c o n t r o l l e d s t u d y of f i b r o m y a l g i a i n IBS p a t i e n t s . (Abstract# G3450) A Sperber, Y Atzmon, I Weitzman, Y Shalit, A Fich, L Neumann and D Bouskila. Beer Sheva, Israel

5:00

Differences i n left p r e f r o n t a l a c t i v a t i o n to v i s c e r a l a n d s o m a t i c s t i m u l i a s s e s s e d b y 0-15w a t e r PET in f e m a l e p a t i e n t s w i t h i r r i t a b l e b o w e l s y n d r o m e a n d f i b r o m y a l g i a . (Abstract# G3023) L Chang, EA Mayer, J Munakata, DHS Sflverman, S Berman, S Gilmore, L FitzGerald, M Schmulson, MA Mandelkern and B Naliboff. Los Angeles and Torrance, CA

5:15

P s y c h o l o g i c a l d i s t r e s s a n d i m p a i r e d q u a l i t y of life in p a t i e n t s w i t h f u n c t i o n a l a n o r e c t a l d i s o r d e r s . (Abstract# G3012) C Burnett, O Palsson, WE Whitehead and D Drossman. Chapel Hill, NC and Norfolk, VA

Room 64 / 65 / 66 Ernest N. Morial Convention Center

Chairs: Nimish Vakil, Julie Parsonnet E F F E C T S O F T H E R A P Y ON HELICOBACTER PYLORI-ASSOCIATED GASTRIC P R E N E O P L A S I A 4:00

The r e l a t i o n of CagA a n d t h e l o n g t e r m s e q u e l a e o f g a s t r i t i s a f t e r successful c u r e o f H. pylori infection: a l o n g t e r m follow-up study. (Abstract# G1302) RWM van der Hulst, FJW ten Kate, EAJ Rauws, A van der Ende, B K6yc(i, JGP Tyssen and GNJ Tytgat. Amsterdam, The Netherlands

4:15

Helicobacter pylori i n f e c t i o n a n d i n t e s t i n a l m e t a p l a s i a i n t h e s t o m a c h : t w o y e a r s follow-up a f t e r e r a d i c a t i o n . (Abstract# G1090) M Ravizza, R Suriani, U Giacobbe, F Cappelletti and P Dusio. Turin, Italy

4:30

R e c o v e r y of g a s t r i c a c i d s e c r e t i o n a n d m u c o s a l a t r o p h y a f t e r H. pylori e r a d i c a t i o n in s e v e r e a t r o p h i c g a s t r i t i s . (Abstract# G0640) K Iijima, S Ohara, H Sekine, T Koike, Y Kubota, K Kato, S Asaki and T Toyota. Sendai, Japan

4:45

5:00

5:15

It. pylorY e r a d i c a t i o n for c h r o n i c g a s t r i t i s d u r i n g o m e p r a z o l e t h e r a p y for GERD. (Abstract# Gl144) BE Schenk, EJ Kuipers, GF Nelis, JC Thijs, E Bloemena, P Snel, PLuckers, EC KlinkenbergKnol, HPM Festen, PP Viergever, J Lindeman, A Cats and SGM Meuwissen. Amsterdam, Zwolle, Hoogeveen and Boxmeer, The Netherlands The effect of a c i d s u p p r e s s i o n on H. pylorl g a s t r i t i s is d o s e - d e p e n d e n t . (Abstract# G0753) J J Kolkman, HJA Hazenberg, N Dekkers, JA Beker, E Bloemena, SGM Meuwissen and EJ Kuipers. Amsterdam, The Netherlands G a s t r i c m o r p h o l o g y d u r i n g long t e r m o m e p r a z o l e t h e r a p y . (Abstract# G0593) N Havu. S6dert/ilge, Sweden

Motility and Nerve-Gut Interactions AGA Research Forum

4:00-5:30 p m

Room 95/96 Ernest N. Morial Convention Center

Chairs: William E. Whitehead, Howard R. Mertz FIBROMYALGIA, I N F E C T I O N , S T R E S S AND IBS 4:00

E v i d e n c e of i n f l a m m a t o r y p a t h o g e n e s i s i n postinfectious irritable bowel syndrome. (Abstract# G3127) KA Gwee, SM Collins, JS Marshall, JE Underwood, SM Moochala and NW Read. Singapore, Singapore; Hamilton, Canada and Sheffield, United Kingdom

Immunology, Microbiology, and Inflammatory D i s e a s e s W r a p Up

4:00-5:30 p m

Ballroom C Ernest N. Morial Convention Center

H I G H L I G H T S O F IMMUNOLOGY, M I C R O B I O L O G Y AND I N F L A M M A T O R Y B O W E L D I S E A S E AT DDW98 Microbiology. Thomas LaMont. Boston, MA Immunology, inflammation, and basic inflammatory bowel d i s e a s e r e s e a r c h . Stephen P. James. Baltimore, MD I n f l a m m a t o r y b o w e l disease. Stephen B. Hanauer. Chicago, IL