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Agreements to calculate cardiovascular risk by standardized models in Spanish population
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Abstracts / Atherosclerosis 235 (2014) e192–e301
71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-1127. PROGNOSTIC VALUE OF LDL/HDL CHOLESTEROL RATIO IN PATIENTS UNDERGOING CORONARY STENTING a
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S. Novo , F. Macaione , F.P. Guarneri , E. Corrado , S. Evola , G. Novo a
Division of Cardiology, University of Palermo, Palermo, Italy
Methods: The study included 504 patients with acute coronary syndrome (ACS), undergoing PCI with stent implantation, between November 2006 and December 2008. On the base of periprocedural LDL-c/HDL-c ratio, the patients were grouped as those with, LDL-c/HDL-c 1.5 (n¼ 105, group 1), LDL-C/ HDL-C > 1.5 and 2.0 (n¼ 140, group 2), and LDL-c/HDL-c > 2.0 (n¼ 259, group 3). We evaluated, in the three groups, the incidence of MACE during three years. Results: The patients of the group 3 had a significantly more incidence of MACE (45.55%) compared with group 1 (20.95%) and group 2 (27.85%). By multivariate analysis LDL-c/HDL-c ratio (OR 1.593; 95%CI 1.335 -1,901; p<0.0001) and fibrinogen (OR 1.003; 95%CI 1.001 -1.005; p¼ 0.0004) appeared to be an independent predictor of MACE. The ROC curve analyses showed that the best marker of MACE was LDL-c/HDL-c ratio, with an area under the ROC curve of 0.66 (95%CI 0, 61 to 0, 69). The optimal cut-off point to identifying the incidence of MACE for LDL-C/HDL-c ratio was 1.85. Conclusion: LDL-c/HDL-c ratio and inflammation have an important role in the prediction of future cardiovascular events after PCI. 71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous
RISK
BY
M. Artachoa, M. Olmedoa, J. Millana a
71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-0866. CARDIOVASCULAR LIFESTYLE UNIVERSITARY STUDENTS
PROFILE
IN
UNDERGRADUATES
J. Millana, C. Recarte Garcia-Andradeb, L. Alvarez-Sala Waltherb
Objectives: This study aimed to appraise the role of a low-density lipoprotein cholesterol /high-density lipoprotein-cholesterol (LDL-c/HDL-c) ratio as predictors of major adverse cardiac events (MACE) after percutaneous coronary intervention (PCI).
EAS-0894. AGREEMENTS TO CALCULATE CARDIOVASCULAR STANDARDIZED MODELS IN SPANISH POPULATION
a CV risk differently depending on the scale which has been used and, therefore, therapeutic intervention would also likely different.
Internal Medicine, HGU Gregorio Marañón, Madrid, Spain
Objectives: In last decades, scientific community have investigated statistic models which estimate individual cardiovascular risk (ICR). First model was derived from Framingham study group, valid for American population. Recently, other investigators have made calibrated models for other population, in which prevalence of the major CRF are different. The objective of this study is to evaluate agreements of main models in Spanish population. Methods: We achieved a cross-sectional descriptive study with a cohort of 652 people selected by convenience sampling in a healthy convention in Ferial Institute of Madrid (IFEMA). That is the preliminary analysis of first 274 people (63,9% women), aged from 30 to 74 years old. Mean age was 58,25 years. Measurements: age, sex, blood pressure, glycaemia, lipids, smokers, medical history of CVD and cardiovascular risk calculated with Framingham, SCORE (low risk algorithm), REGICOR and DORICA scales. Results: There is a strong positive correlation between the four scales (rho Spearman: 0,78; p < 0,001) with the exception of SCORE-REGICOR and SCORE-DORICA which present a good positive correlation (rho Spearman: 0,59 both; p < 0,001). The agreement using Kappa index was: Framingham-SCORE, 0,441; Framingham-REGICOR, 0,200; Framingham-DORICA, 0,517; SCOREREGICOR, 0,244; SCORE-DORICA, 0,290; REGICOR-DORICA, 0,444 (all of them: p < 0,001). Conclusion: We can assert in order to preliminary analysis that, given the correlation between different scales, any of the four scales could order a population in a similar way in terms of CV risk. However, the agreement between them becomes not good, so that a patient could be classified with
a b
Interna Medicine, HGU Gregorio Marñon. School o Medicine, Madrid, Spain; Internal Medicine, HGU Gregorio Marñon. School o Medicine, Madrid, Spain
Objectives: A limited number of papers has been made related with the cardiovascular lifestyle in young people during the universitary studies. But it could be of interest to evaluate the habits in undergraduate students, particullary in health sciences students. The aim of this study has been to know these habits. Methods: We shown an observational study in undergraduates of healt sciences grades in the university. A questionnary was made to 154 students of the last year of undergraduate training. The mean age was 23,4 years (SD: 1,98); 67,5 % were female and 32, 5 male. Results: Body Mass Index in the studied groups was 21,78 Kg/m2 (SD: 2,73) with the distribution of percentiles as follow: p25:19,7, p50:21,45, p75:23,10. 9,7 % were smokers; ex-smokers: 5,2 %. Alcoholic beverages were taken at weekend in 24 %, daily: 2,6%, and occasional: 67,5 %. According with physical activities: sport practice: 24 %, every day regular physical activity: 36,4 %; and never: 18,2 %. Dietary intake was evaluated by a specific questionnary. Conclusion: The studied groups seems a lifestyle profile accordance with the main recommendations, and more favourable tan otghers observed in another studies.nevertheles, we have detected some options to improve the dietetic habits and the percentage of physical activities practitioners. 71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-1052. TOTAL FAT INTAKE MODIFIES THE ASSOCIATION BETWEEN APOLIPOPROTEIN B AND RISK OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH STABLE ANGINA PECTORIS O. Nygårda, G.F.T. Svingena, E. Skeieb, N. Puaschitzb, E. Stranda, C.A. Drevonc, V. Lysnea, T. Olsena, H. Schartum-Hansenb, T. Karlssona, E.R. Pedersena K2, Department of clinical sciences, Bergen, Norway; b Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; c Department of Clinical Nutrition, Institute of Basic Medical Sciences, Oslo, Norway
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Objectives: Elevated levels of apolipoprotein B (apoB) and the extent of coronary artery disease (CAD) are important determinants of future risk of acute myocardial infarction (AMI) in patients with stable angina pectoris (SAP). However, the influence of dietary fat intake on these relations is highly debated. Methods: Patients undergoing coronary angiography for suspected SAP were studied. Information on dietary habits was collected by food frequency questionnaire among 2034 patients, who were followed for median 4.7 years. Cox regression was used to calculate hazard ratios (HRs) and their respective 95% confidence intervals (CI) for AMI across apoB quartiles and extent of CAD (scored 0-3, according to number of epicardial coronary arteries with significant stenosis). Models were additionally adjusted for age, gender, smoking, diabetes and statin therapy. Subgroup analyses were carried out according to tertiles of estimated daily fat intake. Results: The estimated median (33.3-66.7 percentile) intake of total fat was 31.2 (28.9-33.5) % of the daily total energy intake. A total of 165 patients (8.1%) suffered an AMI, and elevated apoB and the extent of CAD were linearly associated with increased risk (HR [95% CI] per apoB quartile 1.18
Abstracts / Atherosclerosis 235 (2014) e192–e301
71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-1127. PROGNOSTIC VALUE OF LDL/HDL CHOLESTEROL RATIO IN PATIENTS UNDERGOING CORONARY STENTING a
a
a
a
a
a
S. Novo , F. Macaione , F.P. Guarneri , E. Corrado , S. Evola , G. Novo a
Division of Cardiology, University of Palermo, Palermo, Italy
Methods: The study included 504 patients with acute coronary syndrome (ACS), undergoing PCI with stent implantation, between November 2006 and December 2008. On the base of periprocedural LDL-c/HDL-c ratio, the patients were grouped as those with, LDL-c/HDL-c 1.5 (n¼ 105, group 1), LDL-C/ HDL-C > 1.5 and 2.0 (n¼ 140, group 2), and LDL-c/HDL-c > 2.0 (n¼ 259, group 3). We evaluated, in the three groups, the incidence of MACE during three years. Results: The patients of the group 3 had a significantly more incidence of MACE (45.55%) compared with group 1 (20.95%) and group 2 (27.85%). By multivariate analysis LDL-c/HDL-c ratio (OR 1.593; 95%CI 1.335 -1,901; p<0.0001) and fibrinogen (OR 1.003; 95%CI 1.001 -1.005; p¼ 0.0004) appeared to be an independent predictor of MACE. The ROC curve analyses showed that the best marker of MACE was LDL-c/HDL-c ratio, with an area under the ROC curve of 0.66 (95%CI 0, 61 to 0, 69). The optimal cut-off point to identifying the incidence of MACE for LDL-C/HDL-c ratio was 1.85. Conclusion: LDL-c/HDL-c ratio and inflammation have an important role in the prediction of future cardiovascular events after PCI. 71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous
RISK
BY
M. Artachoa, M. Olmedoa, J. Millana a
71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-0866. CARDIOVASCULAR LIFESTYLE UNIVERSITARY STUDENTS
PROFILE
IN
UNDERGRADUATES
J. Millana, C. Recarte Garcia-Andradeb, L. Alvarez-Sala Waltherb
Objectives: This study aimed to appraise the role of a low-density lipoprotein cholesterol /high-density lipoprotein-cholesterol (LDL-c/HDL-c) ratio as predictors of major adverse cardiac events (MACE) after percutaneous coronary intervention (PCI).
EAS-0894. AGREEMENTS TO CALCULATE CARDIOVASCULAR STANDARDIZED MODELS IN SPANISH POPULATION
a CV risk differently depending on the scale which has been used and, therefore, therapeutic intervention would also likely different.
Internal Medicine, HGU Gregorio Marañón, Madrid, Spain
Objectives: In last decades, scientific community have investigated statistic models which estimate individual cardiovascular risk (ICR). First model was derived from Framingham study group, valid for American population. Recently, other investigators have made calibrated models for other population, in which prevalence of the major CRF are different. The objective of this study is to evaluate agreements of main models in Spanish population. Methods: We achieved a cross-sectional descriptive study with a cohort of 652 people selected by convenience sampling in a healthy convention in Ferial Institute of Madrid (IFEMA). That is the preliminary analysis of first 274 people (63,9% women), aged from 30 to 74 years old. Mean age was 58,25 years. Measurements: age, sex, blood pressure, glycaemia, lipids, smokers, medical history of CVD and cardiovascular risk calculated with Framingham, SCORE (low risk algorithm), REGICOR and DORICA scales. Results: There is a strong positive correlation between the four scales (rho Spearman: 0,78; p < 0,001) with the exception of SCORE-REGICOR and SCORE-DORICA which present a good positive correlation (rho Spearman: 0,59 both; p < 0,001). The agreement using Kappa index was: Framingham-SCORE, 0,441; Framingham-REGICOR, 0,200; Framingham-DORICA, 0,517; SCOREREGICOR, 0,244; SCORE-DORICA, 0,290; REGICOR-DORICA, 0,444 (all of them: p < 0,001). Conclusion: We can assert in order to preliminary analysis that, given the correlation between different scales, any of the four scales could order a population in a similar way in terms of CV risk. However, the agreement between them becomes not good, so that a patient could be classified with
a b
Interna Medicine, HGU Gregorio Marñon. School o Medicine, Madrid, Spain; Internal Medicine, HGU Gregorio Marñon. School o Medicine, Madrid, Spain
Objectives: A limited number of papers has been made related with the cardiovascular lifestyle in young people during the universitary studies. But it could be of interest to evaluate the habits in undergraduate students, particullary in health sciences students. The aim of this study has been to know these habits. Methods: We shown an observational study in undergraduates of healt sciences grades in the university. A questionnary was made to 154 students of the last year of undergraduate training. The mean age was 23,4 years (SD: 1,98); 67,5 % were female and 32, 5 male. Results: Body Mass Index in the studied groups was 21,78 Kg/m2 (SD: 2,73) with the distribution of percentiles as follow: p25:19,7, p50:21,45, p75:23,10. 9,7 % were smokers; ex-smokers: 5,2 %. Alcoholic beverages were taken at weekend in 24 %, daily: 2,6%, and occasional: 67,5 %. According with physical activities: sport practice: 24 %, every day regular physical activity: 36,4 %; and never: 18,2 %. Dietary intake was evaluated by a specific questionnary. Conclusion: The studied groups seems a lifestyle profile accordance with the main recommendations, and more favourable tan otghers observed in another studies.nevertheles, we have detected some options to improve the dietetic habits and the percentage of physical activities practitioners. 71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-1052. TOTAL FAT INTAKE MODIFIES THE ASSOCIATION BETWEEN APOLIPOPROTEIN B AND RISK OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH STABLE ANGINA PECTORIS O. Nygårda, G.F.T. Svingena, E. Skeieb, N. Puaschitzb, E. Stranda, C.A. Drevonc, V. Lysnea, T. Olsena, H. Schartum-Hansenb, T. Karlssona, E.R. Pedersena K2, Department of clinical sciences, Bergen, Norway; b Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; c Department of Clinical Nutrition, Institute of Basic Medical Sciences, Oslo, Norway
a
Objectives: Elevated levels of apolipoprotein B (apoB) and the extent of coronary artery disease (CAD) are important determinants of future risk of acute myocardial infarction (AMI) in patients with stable angina pectoris (SAP). However, the influence of dietary fat intake on these relations is highly debated. Methods: Patients undergoing coronary angiography for suspected SAP were studied. Information on dietary habits was collected by food frequency questionnaire among 2034 patients, who were followed for median 4.7 years. Cox regression was used to calculate hazard ratios (HRs) and their respective 95% confidence intervals (CI) for AMI across apoB quartiles and extent of CAD (scored 0-3, according to number of epicardial coronary arteries with significant stenosis). Models were additionally adjusted for age, gender, smoking, diabetes and statin therapy. Subgroup analyses were carried out according to tertiles of estimated daily fat intake. Results: The estimated median (33.3-66.7 percentile) intake of total fat was 31.2 (28.9-33.5) % of the daily total energy intake. A total of 165 patients (8.1%) suffered an AMI, and elevated apoB and the extent of CAD were linearly associated with increased risk (HR [95% CI] per apoB quartile 1.18