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Analysis of morbidity of syphilis in Bulgaria, 1990–1997
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FC3. FC3-1
FC3. AIDS/Sexually
AIDS/Sexually transmitted diseases The influence of Trichophyton rubrum the production of the human immunodeficiency virus by H9 cells
A.G. Katsitadze. Medical
University,
Tbilisi,
on
Georgia
The effect of Trichophyton rubrum (Tr. rubrum) infection on the replication of Human Immunodeliciency Virus (HIV) were examined electron-microscopically and by assay of reverse transcriptase (RT) activity. It was found that in the Tr. rubrum infected cells the number of HIV virions and activity of RT were significantly higher than in control cultures. The so-called minimal and giant forms of HIV were formed during dual fungal-viral infection. It was found that HIV may adherence on the Tr. rubrum cell surface. These findings suggest that Tr. rubrum appear to be very potent activating agent for the production of high HIV titres. From a clinical point of view, our finding may have important significance for HIV-infected patient who acquire Tr. rubrum infection, which may enhance and accelerate HIV propagation in patients and contribute to the development of immunodeficiency. I FC3 2 Why is there no reduction syphilis in Latvia? S. Rubins, A. Rubins. Medical street
16, Riga.
Academy
in morbidity of Latvia,
with
Dzirciema
Latvia
The objective of the present study is to elucidate why in Latvia the morbidity with syphilis, including congenital syphilis, has been so high in recent years and why there is no decrease in the morbidity level. In 1997, there were 3008 new registered syphilis cases in Latvia (i.e. 120 cases per 100 000 inhabitants), and out of them 22 children suffered from congenital syphilis. All epidemiological and clinical data have been summarized on syphilis patients in whom the diagnosis was confirmed by finding spirochete or by serological tests. The ways of infection were ascertained, as well as the knowledge of patients concerning the disease. Conclusion: The level of syphilis morbidity is so high due to two reasons: (1) The population is not sufficiently educated either about sexually transmitted diseases, also syphilis, or about the possible ways of infection; (2) The government does not assign funds for developing educational preventive programmes and measures concerning sexually transmitted diseases that would greatly contribute to the reduction of morbidity. FC3-3
Analysis Bulgaria,
of morbidity 1990-l 997
of syphilis
in
R. Dentcheva, G. Spirov, D. Njagolova, N. Kirjakova, N. Tsankov. Deptartment of Dermato-Venereology, University
of Sofia,
Bulgaria
The aim of the study is to analyse morbidity of syphilis for 1990-1997 period as well as to estimate the effectiveness of treatment and to summarize causative factors for its increasing.
transmitted
s131
diseases
A significant increase of the number of syphilis patients has been registrated during that period - from 378 in 1990 and 452 in 1991 to 2298 in 1996 and 2138 in 1997. An important characteristic of morbidity is the prevalance of contagious forms - the frequency is 94.70% out of all syphilis patients. The number of the earliest stage patients among men is 3 times higher than that among women. The increase of number of lues congenita patients is another important factor. It was 0.26% in 1990 and 1.4% in 1997. The treatment applied is standardisied for the country and is considered to be highly effective. Due to the high number of syphilis patients the future efforts should be concentrated on decreasing of syphilis morbidity and earlier diagnostic. FC3-4
Seroprevalence of HSV2 infection using ’ RIBA type specific assay in 2 sexually active populations in Paris
a
B. Halioua’, T.D. Ly’, T. Prazuck’, J.M. Bohbot’, G. Raguin*, J.E. Malkin’. ‘lnstitut A&d Foumiez Paris; zH6pital La Croix
Saint Simon,
Paris,
France
Objective: To determine HSV2 semprevalencein a female population attending a testing center for HIV and in a population of pregnant women. To identify risk factors associated with HSV2 infection. Methods: 1. Populations: 361 female under 30 years attending a HIV free and anonymous testing center (population 1) were sequentially included in the study and filled a standardized questionnaire concerning social data and sexual behavior. 187 sera from pregnant women (population 2) were analyzed anonymously. 2. Technic: RIBA HSV type l/2 SIA (Cbiron Diagnostic) using individual HSVlR specific recombinant antigens was used to analyze all sera from both populations. Results: 1. Seroprevalence (%): Age S-19
Population Populntion2I
16.6 5.8
20-24
25-29
30-34
>35
23.7 17.6
26.4 23.1
37.8
45.1 -
In both populations there is a significant increase of semprevalence with age, and the age statified rates were similar in the 2 populations. In population 1,9.7% (6/62) of HSV2 + subjects reported a history of symptomatic genital herpes. 2. Risk factors: In population 1, the only risk factor identified was a history of previous STD @ < 0.01, or = 2.9). Ethnic origin, country residence, marital status and stability of sexual relationship were not significantly associated with HSV2 sempositivity. Conclusions: These results using a type specific HSV assay show a similar semprevalence of HSV2 infection in female populations in Paris than in other industrialized countries. Further studies are needed in large samples of population to confirm these data and to assess more precisely the risk factors associated with HSV2 infection.
FC3. FC3-1
FC3. AIDS/Sexually
AIDS/Sexually transmitted diseases The influence of Trichophyton rubrum the production of the human immunodeficiency virus by H9 cells
A.G. Katsitadze. Medical
University,
Tbilisi,
on
Georgia
The effect of Trichophyton rubrum (Tr. rubrum) infection on the replication of Human Immunodeliciency Virus (HIV) were examined electron-microscopically and by assay of reverse transcriptase (RT) activity. It was found that in the Tr. rubrum infected cells the number of HIV virions and activity of RT were significantly higher than in control cultures. The so-called minimal and giant forms of HIV were formed during dual fungal-viral infection. It was found that HIV may adherence on the Tr. rubrum cell surface. These findings suggest that Tr. rubrum appear to be very potent activating agent for the production of high HIV titres. From a clinical point of view, our finding may have important significance for HIV-infected patient who acquire Tr. rubrum infection, which may enhance and accelerate HIV propagation in patients and contribute to the development of immunodeficiency. I FC3 2 Why is there no reduction syphilis in Latvia? S. Rubins, A. Rubins. Medical street
16, Riga.
Academy
in morbidity of Latvia,
with
Dzirciema
Latvia
The objective of the present study is to elucidate why in Latvia the morbidity with syphilis, including congenital syphilis, has been so high in recent years and why there is no decrease in the morbidity level. In 1997, there were 3008 new registered syphilis cases in Latvia (i.e. 120 cases per 100 000 inhabitants), and out of them 22 children suffered from congenital syphilis. All epidemiological and clinical data have been summarized on syphilis patients in whom the diagnosis was confirmed by finding spirochete or by serological tests. The ways of infection were ascertained, as well as the knowledge of patients concerning the disease. Conclusion: The level of syphilis morbidity is so high due to two reasons: (1) The population is not sufficiently educated either about sexually transmitted diseases, also syphilis, or about the possible ways of infection; (2) The government does not assign funds for developing educational preventive programmes and measures concerning sexually transmitted diseases that would greatly contribute to the reduction of morbidity. FC3-3
Analysis Bulgaria,
of morbidity 1990-l 997
of syphilis
in
R. Dentcheva, G. Spirov, D. Njagolova, N. Kirjakova, N. Tsankov. Deptartment of Dermato-Venereology, University
of Sofia,
Bulgaria
The aim of the study is to analyse morbidity of syphilis for 1990-1997 period as well as to estimate the effectiveness of treatment and to summarize causative factors for its increasing.
transmitted
s131
diseases
A significant increase of the number of syphilis patients has been registrated during that period - from 378 in 1990 and 452 in 1991 to 2298 in 1996 and 2138 in 1997. An important characteristic of morbidity is the prevalance of contagious forms - the frequency is 94.70% out of all syphilis patients. The number of the earliest stage patients among men is 3 times higher than that among women. The increase of number of lues congenita patients is another important factor. It was 0.26% in 1990 and 1.4% in 1997. The treatment applied is standardisied for the country and is considered to be highly effective. Due to the high number of syphilis patients the future efforts should be concentrated on decreasing of syphilis morbidity and earlier diagnostic. FC3-4
Seroprevalence of HSV2 infection using ’ RIBA type specific assay in 2 sexually active populations in Paris
a
B. Halioua’, T.D. Ly’, T. Prazuck’, J.M. Bohbot’, G. Raguin*, J.E. Malkin’. ‘lnstitut A&d Foumiez Paris; zH6pital La Croix
Saint Simon,
Paris,
France
Objective: To determine HSV2 semprevalencein a female population attending a testing center for HIV and in a population of pregnant women. To identify risk factors associated with HSV2 infection. Methods: 1. Populations: 361 female under 30 years attending a HIV free and anonymous testing center (population 1) were sequentially included in the study and filled a standardized questionnaire concerning social data and sexual behavior. 187 sera from pregnant women (population 2) were analyzed anonymously. 2. Technic: RIBA HSV type l/2 SIA (Cbiron Diagnostic) using individual HSVlR specific recombinant antigens was used to analyze all sera from both populations. Results: 1. Seroprevalence (%): Age S-19
Population Populntion2I
16.6 5.8
20-24
25-29
30-34
>35
23.7 17.6
26.4 23.1
37.8
45.1 -
In both populations there is a significant increase of semprevalence with age, and the age statified rates were similar in the 2 populations. In population 1,9.7% (6/62) of HSV2 + subjects reported a history of symptomatic genital herpes. 2. Risk factors: In population 1, the only risk factor identified was a history of previous STD @ < 0.01, or = 2.9). Ethnic origin, country residence, marital status and stability of sexual relationship were not significantly associated with HSV2 sempositivity. Conclusions: These results using a type specific HSV assay show a similar semprevalence of HSV2 infection in female populations in Paris than in other industrialized countries. Further studies are needed in large samples of population to confirm these data and to assess more precisely the risk factors associated with HSV2 infection.