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Anti-inflammatory effect of colchicine in Japanese patients with stable coronary artery disease: A pilot study
Abstract
776 An article on the effect of physiotherapy within a heart failure outreach service on participation in structured exercise training M. King ∗ , J. McVeigh, R. Wickham Heartlink- Heart Failure Service, Prince of Wales Hospital, Randwick, New South Wales, Australia Introduction: Exercise training is recommended for people with stable heart failure. However, uptake of structured exercise programs has been reported to be low in this population. Heart failure outreach services face challenges in facilitating self-management strategies for patients, including exercise training. Physiotherapists can assist in promoting and engaging people with heart failure in structured exercise training programs, however physiotherapists appear to be less utilised in heart failure services. Objectives: To determine if the inclusion of a physiotherapist within a heart failure outreach service improved patient participation in structured exercise programs. Methods: A retrospective analysis from the existing hospital database was conducted on structured exercise program attendance in the twelve months prior (January-December 2013) and twelve months following (January-December 2014) the commencement of a heart failure physiotherapist on all patients referred to the outreach service at Prince of Wales Hospital, Randwick. Results: Data was available for 202 patients referred and reviewed by the service in 2013 (n=87) and 2014 (n=115). Compared to the 12 month period prior to the commencement of the physiotherapist, in the 12 months following commencement of the physiotherapist there was an increased proportion of patients attending cardiac rehabilitation (7% vs 23%, p=.002) and pulmonary rehabilitation (2% vs 13%, p=.007), and there was a significant reduction in the number of patients refusing to participate in exercise (32% vs 7%, p<0.001). Conclusion: The inclusion of a physiotherapist within a heart failure outreach service improved participation in structured exercise training. http://dx.doi.org/10.1016/j.hlc.2015.06.779 777 This abstract has been withdrawn.
S449
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778 Anti-inflammatory effect of colchicine in Japanese patients with stable coronary artery disease: A pilot study T. Yakushiji ∗ , M. Ono, W. Igawa, K. Takehiko, S. Ebara, T. Okabe, K. Yamashita, M. Yamamoto, K. Hoshimoto, S. Saito, K. Amemiya, N. Isomura, H. Araki, M. Ochiai Showa University Northern Yokohama Hospital, Japan Background: We sought to verify the safety and antiinflammatory effect of colchicine in Japanese patients with stable coronary artery disease. Methods: Among post-PCI patients who underwent routine follow-up coronary angiography, 55 patients (colchicine group) were prospectively enrolled after exclusion of patients who required subsequent revascularisation. A daily dose of colchicine 0.5mg was administered for 2 weeks. The high-sensitive C-reactive protein (hs-CRP) levels before angiography and after colchicine administration were compared and frequency of side effects by colchicine was assessed. As the control group without colchicine administration, hs-CRP was measured initially and after 2 weeks in 49 patients meeting the same criteria. Results: In 55 patients enrolled, 8 patients experienced adverse effects from colchicine (5 patients with diarrhoea, 2 patients with gastric pain, and 1 patient with skin rash), 3 patients with diarrhoea discontinued colchicine before reaching planned 2 weeks. In 50 patients with available hs-CRP measurement before and after colchicine administration, the average hs-CRP level was significantly decreased after 2 weeks of colchicine (0.91±1.00 vs. 0.54±0.56 mg/L, p=0.005). In contrast, the average hs-CRP level was not decreased after 2 weeks in the control group (1.10±1.51 vs. 1.06±1.27 mg/L, p=0.90). Conclusions: In Japanese patients with stable coronary artery disease, colchicine was well tolerated during the 2 weeks of daily administration. The average hs-CRP level was significantly decreased after 2 weeks of colchicine. http://dx.doi.org/10.1016/j.hlc.2015.06.781
776 An article on the effect of physiotherapy within a heart failure outreach service on participation in structured exercise training M. King ∗ , J. McVeigh, R. Wickham Heartlink- Heart Failure Service, Prince of Wales Hospital, Randwick, New South Wales, Australia Introduction: Exercise training is recommended for people with stable heart failure. However, uptake of structured exercise programs has been reported to be low in this population. Heart failure outreach services face challenges in facilitating self-management strategies for patients, including exercise training. Physiotherapists can assist in promoting and engaging people with heart failure in structured exercise training programs, however physiotherapists appear to be less utilised in heart failure services. Objectives: To determine if the inclusion of a physiotherapist within a heart failure outreach service improved patient participation in structured exercise programs. Methods: A retrospective analysis from the existing hospital database was conducted on structured exercise program attendance in the twelve months prior (January-December 2013) and twelve months following (January-December 2014) the commencement of a heart failure physiotherapist on all patients referred to the outreach service at Prince of Wales Hospital, Randwick. Results: Data was available for 202 patients referred and reviewed by the service in 2013 (n=87) and 2014 (n=115). Compared to the 12 month period prior to the commencement of the physiotherapist, in the 12 months following commencement of the physiotherapist there was an increased proportion of patients attending cardiac rehabilitation (7% vs 23%, p=.002) and pulmonary rehabilitation (2% vs 13%, p=.007), and there was a significant reduction in the number of patients refusing to participate in exercise (32% vs 7%, p<0.001). Conclusion: The inclusion of a physiotherapist within a heart failure outreach service improved participation in structured exercise training. http://dx.doi.org/10.1016/j.hlc.2015.06.779 777 This abstract has been withdrawn.
S449
.. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..
778 Anti-inflammatory effect of colchicine in Japanese patients with stable coronary artery disease: A pilot study T. Yakushiji ∗ , M. Ono, W. Igawa, K. Takehiko, S. Ebara, T. Okabe, K. Yamashita, M. Yamamoto, K. Hoshimoto, S. Saito, K. Amemiya, N. Isomura, H. Araki, M. Ochiai Showa University Northern Yokohama Hospital, Japan Background: We sought to verify the safety and antiinflammatory effect of colchicine in Japanese patients with stable coronary artery disease. Methods: Among post-PCI patients who underwent routine follow-up coronary angiography, 55 patients (colchicine group) were prospectively enrolled after exclusion of patients who required subsequent revascularisation. A daily dose of colchicine 0.5mg was administered for 2 weeks. The high-sensitive C-reactive protein (hs-CRP) levels before angiography and after colchicine administration were compared and frequency of side effects by colchicine was assessed. As the control group without colchicine administration, hs-CRP was measured initially and after 2 weeks in 49 patients meeting the same criteria. Results: In 55 patients enrolled, 8 patients experienced adverse effects from colchicine (5 patients with diarrhoea, 2 patients with gastric pain, and 1 patient with skin rash), 3 patients with diarrhoea discontinued colchicine before reaching planned 2 weeks. In 50 patients with available hs-CRP measurement before and after colchicine administration, the average hs-CRP level was significantly decreased after 2 weeks of colchicine (0.91±1.00 vs. 0.54±0.56 mg/L, p=0.005). In contrast, the average hs-CRP level was not decreased after 2 weeks in the control group (1.10±1.51 vs. 1.06±1.27 mg/L, p=0.90). Conclusions: In Japanese patients with stable coronary artery disease, colchicine was well tolerated during the 2 weeks of daily administration. The average hs-CRP level was significantly decreased after 2 weeks of colchicine. http://dx.doi.org/10.1016/j.hlc.2015.06.781