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Antinociceptive activity of the aerial parts of Solanum xanthocarpum
Fitoterapia 74 (2003) 119–121
Short report
Antinociceptive activity of the aerial parts of Solanum xanthocarpum M.T. Rahman*, M. Ahmed, M. Alimuzzaman, J.A. Shilpi Phytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh Received 19 November 2001; accepted 5 August 2002
Abstract The methanolic extract of Solanum xanthocarpum aerial parts, given orally at 125, 250 and 500 mgykg, showed significant antinociceptive activity in mice. 䊚 2002 Elsevier Science B.V. All rights reserved. Keywords: Solanum xanthocarpum; Analgesic activity; Acetic acid-induced writhing
Plant. Solanum xanthocarpum Schrad. & Wendl. w1x aerial parts (Solanaceae) were collected from Mirpur, Dhaka in May 2001 and taxonomically identified at the Department of Botany, University of Dhaka.
Uses in traditional medicine. Fruit juice is useful in sore throats and rheumatism; decoction of the plant is used in gonorrhoea; paste of leaves is applied to relieve pains; seeds act as expectorant in cough and asthma; roots are expectorant and diuretic, useful in the treatment of catarrhal fever, coughs, asthma and chest pain w1x. The plant has reported beneficial activity in asthma and chronic bronchitis w2,3x and also cardiac stimulatory activity w4x. Solasodine, an alkaloidal constituent of the plant has reported antiandrogenic activity w5x. *Corresponding author. E-mail address: [email protected] (M.T. Rahman). 0367-326X/03/$ - see front matter 䊚 2002 Elsevier Science B.V. All rights reserved. doi:10.1016/S0367-326X(02)00292-7
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M.T. Rahman et al. / Fitoterapia 74 (2003) 119–121
Table 1 Effect of Solanum xanthocarpum aerial parts on acetic acid-induced writhings in mice Treatment
Dose (mgykg, p.o.)a
Writhings (n)b
Control (vehicle, 10 mlykg, p.o.)
–
S. xanthocarpum
125 250 500
22.8"1.34* 18.8"0.89* 13.11"1.66*
53.18 61.40 73.08
Acetylsalicylic acid (ASA)
150
7.0"1.27*
85.63
48.7"1.1
Inhibition (%) –
a
Administered 30 min before 0.6% acetic acid (60 mgykg, i.p.). Counted for 20 min after acetic acid injection; values are mean"S.E.M.; ns6; *P-0.001 vs. control, Student’s t-test. b
Previously isolated class of constituents. Sterols, alkaloids, glycosides w6–9x.
Tested material. Methanolic extract of S. xanthocarpum aerial parts (13.47%): alkaloids, flavonoids, glycosides, sterols and triterpenoids w10x.
Studied activity. Analgesic activity by the acetic acid-induced writhing method described by Koster et al. w11x.
Animals. Swiss albino mice of either sex (average wt. 22–26 g) obtained from the Animal Resources Branch of the International Center for Diarrhoeal Diseases and Research, Bangladesh (ICDDR, B) were used. They were kept in standard environmental conditions and fed with a standard diet (ICDDR, B formulated) and water ad libitum.
Results. Reported in Table 1.
Conclusions. The methanolic extract of S. xanthocarpum aerial parts significantly and dose-dependently suppressed the frequency of acetic acid-induced abdominal constrictions in mice. Acknowledgments The authors would like to thank the Ministry of Science and Technology, Government of People’s Republic of Bangladesh for providing the necessary financial support for the study.
M.T. Rahman et al. / Fitoterapia 74 (2003) 119–121
121
References w1x Ghani A. Medicinal plants of Bangladesh—chemical constituents and uses. Bangladesh: Asiatic society of Bangladesh, 1998. p. 290. w2x Bector NP, Puri AS. J Assoc Phys India 1971;19(10):741. w3x Govindan S, Viswanathan S, Vijayasekaran V, Alagappan R. J Ethnopharmacol 1999;66(2):205. w4x Gupta SS, Verma SC, Singh C, Khandelwal P. Indian J Med Sci 1966;20(8):554. w5x Dixit VP, Gupta RS. Int J Androl 1982;5(3):295. w6x Tupkari SV, Saoji AN, Deshmukh VK. Planta Med 1972;22(2):184. w7x Gupta SS, Verma SC, Singh C, Khandelwal P, Gupta NK. Indian J Med Res 1967;55(7):723. w8x Beisler JA, Sato Y. J Org Chem 1971;36(25):3946. w9x Heble MR, Narayanaswami S, Chadha MS. Science 1967;161(846):1145. w10x Harborne JB. Phytochemical methods. 3rd ed. Chapman and Hall: London, 1984. w11x Koster R, Anderson M, Beer EJ. Fed Proc 1959;18:412.
Short report
Antinociceptive activity of the aerial parts of Solanum xanthocarpum M.T. Rahman*, M. Ahmed, M. Alimuzzaman, J.A. Shilpi Phytochemistry and Pharmacology Research Laboratory, Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh Received 19 November 2001; accepted 5 August 2002
Abstract The methanolic extract of Solanum xanthocarpum aerial parts, given orally at 125, 250 and 500 mgykg, showed significant antinociceptive activity in mice. 䊚 2002 Elsevier Science B.V. All rights reserved. Keywords: Solanum xanthocarpum; Analgesic activity; Acetic acid-induced writhing
Plant. Solanum xanthocarpum Schrad. & Wendl. w1x aerial parts (Solanaceae) were collected from Mirpur, Dhaka in May 2001 and taxonomically identified at the Department of Botany, University of Dhaka.
Uses in traditional medicine. Fruit juice is useful in sore throats and rheumatism; decoction of the plant is used in gonorrhoea; paste of leaves is applied to relieve pains; seeds act as expectorant in cough and asthma; roots are expectorant and diuretic, useful in the treatment of catarrhal fever, coughs, asthma and chest pain w1x. The plant has reported beneficial activity in asthma and chronic bronchitis w2,3x and also cardiac stimulatory activity w4x. Solasodine, an alkaloidal constituent of the plant has reported antiandrogenic activity w5x. *Corresponding author. E-mail address: [email protected] (M.T. Rahman). 0367-326X/03/$ - see front matter 䊚 2002 Elsevier Science B.V. All rights reserved. doi:10.1016/S0367-326X(02)00292-7
120
M.T. Rahman et al. / Fitoterapia 74 (2003) 119–121
Table 1 Effect of Solanum xanthocarpum aerial parts on acetic acid-induced writhings in mice Treatment
Dose (mgykg, p.o.)a
Writhings (n)b
Control (vehicle, 10 mlykg, p.o.)
–
S. xanthocarpum
125 250 500
22.8"1.34* 18.8"0.89* 13.11"1.66*
53.18 61.40 73.08
Acetylsalicylic acid (ASA)
150
7.0"1.27*
85.63
48.7"1.1
Inhibition (%) –
a
Administered 30 min before 0.6% acetic acid (60 mgykg, i.p.). Counted for 20 min after acetic acid injection; values are mean"S.E.M.; ns6; *P-0.001 vs. control, Student’s t-test. b
Previously isolated class of constituents. Sterols, alkaloids, glycosides w6–9x.
Tested material. Methanolic extract of S. xanthocarpum aerial parts (13.47%): alkaloids, flavonoids, glycosides, sterols and triterpenoids w10x.
Studied activity. Analgesic activity by the acetic acid-induced writhing method described by Koster et al. w11x.
Animals. Swiss albino mice of either sex (average wt. 22–26 g) obtained from the Animal Resources Branch of the International Center for Diarrhoeal Diseases and Research, Bangladesh (ICDDR, B) were used. They were kept in standard environmental conditions and fed with a standard diet (ICDDR, B formulated) and water ad libitum.
Results. Reported in Table 1.
Conclusions. The methanolic extract of S. xanthocarpum aerial parts significantly and dose-dependently suppressed the frequency of acetic acid-induced abdominal constrictions in mice. Acknowledgments The authors would like to thank the Ministry of Science and Technology, Government of People’s Republic of Bangladesh for providing the necessary financial support for the study.
M.T. Rahman et al. / Fitoterapia 74 (2003) 119–121
121
References w1x Ghani A. Medicinal plants of Bangladesh—chemical constituents and uses. Bangladesh: Asiatic society of Bangladesh, 1998. p. 290. w2x Bector NP, Puri AS. J Assoc Phys India 1971;19(10):741. w3x Govindan S, Viswanathan S, Vijayasekaran V, Alagappan R. J Ethnopharmacol 1999;66(2):205. w4x Gupta SS, Verma SC, Singh C, Khandelwal P. Indian J Med Sci 1966;20(8):554. w5x Dixit VP, Gupta RS. Int J Androl 1982;5(3):295. w6x Tupkari SV, Saoji AN, Deshmukh VK. Planta Med 1972;22(2):184. w7x Gupta SS, Verma SC, Singh C, Khandelwal P, Gupta NK. Indian J Med Res 1967;55(7):723. w8x Beisler JA, Sato Y. J Org Chem 1971;36(25):3946. w9x Heble MR, Narayanaswami S, Chadha MS. Science 1967;161(846):1145. w10x Harborne JB. Phytochemical methods. 3rd ed. Chapman and Hall: London, 1984. w11x Koster R, Anderson M, Beer EJ. Fed Proc 1959;18:412.