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Bartholin gland carcinoma
80
Qtations from the Literature
The value of the subrenal capsule assay in predicting the response of advanced ovarian cancer to combination chemotherapy was studied prospectively. The population consisted of 24 patients with advanced or recurrent disease. Using a threegrade interpretation of drug response in the assay (sensitive, intermediately, sensitive, and resistant), an overall predictive accuracy of 79% was achieved. All objective clinical responses and acquired drug resistance could be predicted by the assay. It was concluded that the assay is a promising method for predicting response of patients with ovarian cancer to chemotherapy. Bartholin gland carcinoma Copeland LJ; Sneige N; Gershenson DM; et al Department of Gynecology, The University of Texas M.D. Anderson Hospital and Tumor Institute, Houston, TX 77030, USA OBSTET. GYNECOL.; 67/6 (794-801) 1986 Bartholin gland tumors are rare and management recommendations have been based on limited information. This report summarizes a 30-year clinical experience involving Bartholin gland carcinoma in 36 patients whose five-year survival rate was 84%. FIG0 stages of the 36 tumors were stage 1, nine; stage 11, 15; stage HI, ten; and stage IV, two. Cell types were: squamous, 27 (three nonkeratinizing with areas of a transitional component); adenomatous, six; adenoid cystic, two; and adenosquamous, one. Fourteen of 30 (47%) patients with lymph node dissections had nodal metastases and 11 remain disease-free. Disease recurred in nine patients (six local, two distant, one local and distant) and four were treated successfully. One of 14 (7%) patients receiving radiation and six of 22 (27%) patients not receiving radiation developed local recurrences. Wide excision (often necessitating a radical hemivulvectomy), ipsilateral inguinal lymphadenectomy, and adjunctive irradiation to the vulva and regional lymph nodes produced excellent results. Electrocoagulation and the zisk of cervical neoplasia La Vecchia C; Pranceschi Si Decarli A; et al. Istituto di Ricerche Farmacologiche ‘Mari Negri’, 20157 Milan, Italy OBSTET. GYNECOL.; 66/5 (703-707) 1985 The relationship between electrocoagulation diathermy and the risk of cervical neoplasia was evaluated in a casecontrol study of 145 women with cervical intraepithelial neoplasia compared with 145 age-matched outpatient control subjects, and 191 cases of invasive cervical cancer compared with 191 control subjects in the hospital for acute conditions unrelated to any of the identified or suspected risk factors for cervical cancer. History of electrocoagulation was associated with an apparently reduced risk of cervical intraepithelial neoplasia (relative risk = 0.50, with 95% confidence interval = 0.29-0.87), and of invasive cancer (relative risk = 0.42, 95% confidence interval = 0.22-0.82). However, this apparent protection could be largely explained in terms of a different frequency of previous Papanicolaou smears patients and control subjects. When adjustment was made for that variable, the risk estimates of CIN and Int J Gynaecol Obstet 25
invasive cancer among women who had undergone electrocoagulation increased to 0.62 and 0.83 and became statistically nonsignificant. Further allowance for other identified potential confounding factors means of multiple logistic regression raised these estimates to 0.73 and 0.94, respectively. Thus, these data provide evidence against the hypothesis that electrocoagulation may have an important and independent role in the prevention of cervical neoplasia Diagnostic conization of the cervix: Review of 460 consecutive case3 Killackey MA; Jones WB; Lewis JL Jr. The Memorial Sloan Kettering Cancer Center, New York, NY, USA OBSTET. GYNECOL.; 67/6 (766-770) 1986 During a five-year period, 460 patients underwent cervical conization on the Gynecology Service at Memorial Hospital. The pertinent medical history of the 393 patients was reviewed as it related to the diagnosis of cervical intraepithelial neoplasia. All patients had repeat Papanicolaou smears and 94.4% had complete colposcopic examination using standard colposcopic procedures, endocervical curettage, and directed biopsies. For the purpose of this review, patients were separated into seven groups according to the primary and most significant indication for conization. The indications for the procedure and the histopathologic findings are discussed for each category. The usefulness of conization in the authors’ institution varied according to the indication for which it was carried out. In this series of 393 patients, 18 patients (4.7%) initially diagnosed to have only intraepithelial disease, were found to have invasive carcinoma. A comparison between laser excisional conization and laser vaporization for the treatment of cervical intraepithelial neoplasia Baggish MS State University Hospital, Upstate Medical Center, Syracuse, NY 13210, USA AM. J. OBSTET. GYNECOL.; 155/l (39-44) 1986 One hundred twenty patients with cervical intraepithelial neoplasia who were treated by laser excisional conization were compared with a group of 100 women who had similar diagnoses and were treated by laser vaporization. Every operation in the series was performed in the outpatient surgical unit or in the office. In two thirds of the cases the procedures were carried out with the patients under local anesthesia. The parameters studied included time required to perform the procedure, immediate and delayed bleeding, postlaser stenosis, healing time, patient discomfort, persistence or recurrence of disease, and risk of invasion. The results of this study revealed few disadvantages to performing a laser excisional procedure. Immediate and delayed complications were less frequent with laser excisional conization. The time required to perform an excisional conization was on the average only 4 minutes longer than that for a vaporization. Most significantly, the laser excisional cone provides a large and excellent specimen for the pathologist to review.
Qtations from the Literature
The value of the subrenal capsule assay in predicting the response of advanced ovarian cancer to combination chemotherapy was studied prospectively. The population consisted of 24 patients with advanced or recurrent disease. Using a threegrade interpretation of drug response in the assay (sensitive, intermediately, sensitive, and resistant), an overall predictive accuracy of 79% was achieved. All objective clinical responses and acquired drug resistance could be predicted by the assay. It was concluded that the assay is a promising method for predicting response of patients with ovarian cancer to chemotherapy. Bartholin gland carcinoma Copeland LJ; Sneige N; Gershenson DM; et al Department of Gynecology, The University of Texas M.D. Anderson Hospital and Tumor Institute, Houston, TX 77030, USA OBSTET. GYNECOL.; 67/6 (794-801) 1986 Bartholin gland tumors are rare and management recommendations have been based on limited information. This report summarizes a 30-year clinical experience involving Bartholin gland carcinoma in 36 patients whose five-year survival rate was 84%. FIG0 stages of the 36 tumors were stage 1, nine; stage 11, 15; stage HI, ten; and stage IV, two. Cell types were: squamous, 27 (three nonkeratinizing with areas of a transitional component); adenomatous, six; adenoid cystic, two; and adenosquamous, one. Fourteen of 30 (47%) patients with lymph node dissections had nodal metastases and 11 remain disease-free. Disease recurred in nine patients (six local, two distant, one local and distant) and four were treated successfully. One of 14 (7%) patients receiving radiation and six of 22 (27%) patients not receiving radiation developed local recurrences. Wide excision (often necessitating a radical hemivulvectomy), ipsilateral inguinal lymphadenectomy, and adjunctive irradiation to the vulva and regional lymph nodes produced excellent results. Electrocoagulation and the zisk of cervical neoplasia La Vecchia C; Pranceschi Si Decarli A; et al. Istituto di Ricerche Farmacologiche ‘Mari Negri’, 20157 Milan, Italy OBSTET. GYNECOL.; 66/5 (703-707) 1985 The relationship between electrocoagulation diathermy and the risk of cervical neoplasia was evaluated in a casecontrol study of 145 women with cervical intraepithelial neoplasia compared with 145 age-matched outpatient control subjects, and 191 cases of invasive cervical cancer compared with 191 control subjects in the hospital for acute conditions unrelated to any of the identified or suspected risk factors for cervical cancer. History of electrocoagulation was associated with an apparently reduced risk of cervical intraepithelial neoplasia (relative risk = 0.50, with 95% confidence interval = 0.29-0.87), and of invasive cancer (relative risk = 0.42, 95% confidence interval = 0.22-0.82). However, this apparent protection could be largely explained in terms of a different frequency of previous Papanicolaou smears patients and control subjects. When adjustment was made for that variable, the risk estimates of CIN and Int J Gynaecol Obstet 25
invasive cancer among women who had undergone electrocoagulation increased to 0.62 and 0.83 and became statistically nonsignificant. Further allowance for other identified potential confounding factors means of multiple logistic regression raised these estimates to 0.73 and 0.94, respectively. Thus, these data provide evidence against the hypothesis that electrocoagulation may have an important and independent role in the prevention of cervical neoplasia Diagnostic conization of the cervix: Review of 460 consecutive case3 Killackey MA; Jones WB; Lewis JL Jr. The Memorial Sloan Kettering Cancer Center, New York, NY, USA OBSTET. GYNECOL.; 67/6 (766-770) 1986 During a five-year period, 460 patients underwent cervical conization on the Gynecology Service at Memorial Hospital. The pertinent medical history of the 393 patients was reviewed as it related to the diagnosis of cervical intraepithelial neoplasia. All patients had repeat Papanicolaou smears and 94.4% had complete colposcopic examination using standard colposcopic procedures, endocervical curettage, and directed biopsies. For the purpose of this review, patients were separated into seven groups according to the primary and most significant indication for conization. The indications for the procedure and the histopathologic findings are discussed for each category. The usefulness of conization in the authors’ institution varied according to the indication for which it was carried out. In this series of 393 patients, 18 patients (4.7%) initially diagnosed to have only intraepithelial disease, were found to have invasive carcinoma. A comparison between laser excisional conization and laser vaporization for the treatment of cervical intraepithelial neoplasia Baggish MS State University Hospital, Upstate Medical Center, Syracuse, NY 13210, USA AM. J. OBSTET. GYNECOL.; 155/l (39-44) 1986 One hundred twenty patients with cervical intraepithelial neoplasia who were treated by laser excisional conization were compared with a group of 100 women who had similar diagnoses and were treated by laser vaporization. Every operation in the series was performed in the outpatient surgical unit or in the office. In two thirds of the cases the procedures were carried out with the patients under local anesthesia. The parameters studied included time required to perform the procedure, immediate and delayed bleeding, postlaser stenosis, healing time, patient discomfort, persistence or recurrence of disease, and risk of invasion. The results of this study revealed few disadvantages to performing a laser excisional procedure. Immediate and delayed complications were less frequent with laser excisional conization. The time required to perform an excisional conization was on the average only 4 minutes longer than that for a vaporization. Most significantly, the laser excisional cone provides a large and excellent specimen for the pathologist to review.