Biopulping with Phlebia subserialis (M Akhtar et al, US)

• les derniers brevets deposes: morceaux choisis • realisee en collaboration avec J'/npi

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Productions

vegetales

> Method for increasing sucrose content of plants (CN Lacey et ai, GB) Unilever PIc and the inventors W WO 98/01574. PCl Pea seeds, produced from peas of the rug3rug3 genotype, su bstantially lacking plastidial phosphoglucornurase activity which has higher sucrose levels at the end of the vining period and may be vined over and extended period compared to conventionnal vining variety are provided. Polynucleotides encoding pea plastidial phosphoglucomutase useful for altering the sucrose and starch content of plant particularly peas, are also disclosed.

> Method of increasing growth and yield in plants (PW Doerner and CJ Lamb, US) The Salk Institute for Biological Studies N° WO 98/03631, PCl The invention provides a method of producing a genetically modified plant characterized as having increased growth and yield as compared to a corresponding wildtype plant comprising increasing the level of cyclin expression in the plant...

> Virus resistance in plants (IG Atabekov et ai, RU) Zeneca Ltd W WO 98/03668. PCl This invention provides a method for improving or imparting the resistance of an organism to infection by specific viruses. The method involves the production of an RNA transcript mimicking binding sites of the virus specific RNA Dependent RNA Polymerase which is produced by the infecting virus. (... )

Alimentation > Process for the preparation of malted cereals (T Coppens et ai, BE)

46 BIOFUTUR 178 • Mai 1998

Cargill France NV and the inventors N" WO 98/03627. PCl

Biomasse > Biopulping with Phlabia subserialis (M Akhtar et ai, US) Wisconsin Alumni Research Foundation W WO 98/02612. PCT. An improved process for biological treatment of wood for pulping, or biopulping, is based on the use of the species Phlebia subserialis. It has been found that several strains of P subserialis are able to colonize wood and delignify it at temperatures desirable in industrial scale fermentation reactors. (... )

Lutts bic ln qiqu e > Insecticidal bacteria (A Ragni at ai, IT,lL) Bio Integrated Technology Sri W 823215, EP Provided are novel bacteria belonging to the species

Pbotorbabdus luminescens

which possess insecticidal activity which is not dependent of these bacteria being carried bv a nematode infection ve·ctor. (... )

Macromolecules > Antisense oligonucleo-

tides as antibacterial agents (A Arrow et ai, US) Oligos Etc and Ol;gos Therapeutics Inc N° WO 98/03533, PCT. A novel method is provided that teaches the therapeutic use of nuclease resistant oligonucleotides for treating animals having an infection caused by a pathogenic bacterium. (... )

Diagnostic > Fragments d'acides nu-

cleiques specifiques de rnycobacterles membres du complexe M tuberculosis et leurs applications pour la detection et Ie diagnostic differentlel des membres du complexe M

tuberculosis (J Magdalena etal, FR) Institut Pasteur de Lille et Inserm N" 2752425, FR. Cette invention concerne un fragment d'acides nucleiques specifique de rnycobacreries appartenant au complexe M tuberculosis, comprenant un enchainement de nucletotides choisi parmi la sequence SEQ ID nOI, la sequence SEQ ID n° 2, leurs sequences cornplernentaires ou les sequences d'acides nucleiques capable de s'hybrider l'une des sequences precedentes dans des conditions de stringences adequares. Elle vise egalernenr les utilisarions desdites sequences pour la detection er le diagnostic differenriei de mycobacteries rnembre du complexe M tuberculosis, notarnment le diagnostic differenriel du BCG des autres membres du complexe.

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> ADN et proteines/ou peptides specifiques des bacteries de I'espece Neisseria meningltidis, leurs procedes d'obtention et leurs applications biologiques (X Nassif et ai, FR, DE, BE) Inserm, Max-Planck-Gesellschaft zur Foroerunq der Wissenchaften EV, Smithkline Beecham and the inventors N" WO 98/02547, PCT.

Procreation > Immunocontraceptive

compositions containing sperm antigens, and methods of use (JD Bleil at ai, US) The Scripps Research Institute W WO 98100440, PCT. The invention relates generally to imrnunoconrraceptive vaccine compositions comprising antigenic polypeptides having mammalian sp56 sperm protein antigenic determinants (... )

Maladies cardiavascu la lr es > Transgenic animals with mutant human APP or A4CT sequences (S Lichtenthaler at ai, DE, AU)

Smithkline Beecham Pharma GmbH, Smitkline Beecham Australia pty and the inventors N° WO 98/03643, PCT. Constructs comprising a human APP or A4CT DNA sequence encoding mutations which lead to a higher ration of beta A4 1 _42/beta A4 1_40 than wild type and their use in the production of transgenic animals developing amyloid plaques as a model of Alzheimer's disease,

Thera pies geniques et ee tlula ir e > Cationic polymer and lipoprotein-containing system for gene delivery (JS Kim et ai, US, JP) University of Utah Research Foundation N" WO 98/00556, PCT. A composition for delivery of a selected nucleic acid into a targeted host cell comprises a complex of a hydrophobized, positively charged, biocompatible polymer; a lipoprotein; and a selected nucleic acid. Hydrophobic and electrostatic interactions between the components provide for the formation of the condensed DNA-containing complex (... )

> ~rocede de production

d'ADN tMrapeutique (J Crouzet et B Cameron, FR) Rh6ne-Poulenc Rorer SA et les inventeurs N" WO 98/01540. PCT La presence invention concerne la preparation d'ADN, notarnrnent plasmidique. Elle concerne plus particulierement la production d'ADN plasmidique bacrerien qui soir utilisable en therapie genique, so us la forme de plasrnide, de rninicercle surenroule, relache ou lineaire.

> Vactors for delivering viral and oncogenic inhibitors (S Rayback et ai, US) The Government of the United States of America, the Department of Health and Human Services and the inventors N" WO 98/03669, PCT. Cell transformation vectors