Brevets

BREVETS AGRICULTURE tGROINDUSTRII

CHAQUE RI~FI~RENCECOMPORTE ,Letitre . Les inveateers et lear origine ([IS, DK, JP..) , Le dq~ant

numfl'ode pnblkatlen fran(;aist ou eurol~enm Les brevets~ sont aeeessiblcssur Ia base de donn~esde ]'Inpi&s le jour de leur publication.Ceue base est appelde g devenirde plus en pins impoaante, car les ddpoUdes PCT ont teMance ~taugmenter. L'informationest ~ manipulertoutefoisavec r~serve,le d~posamdevantconfitmer son ddpGt. , Le

PRODUCTIONSANIMALES Compositions pharmaceutiqnes destinGes a prevenlr et/ou traiter I'expression du comporlement de cuuvaison chez les oiseaux et plus particulibrement ¢hez la dinde et leurs procidGs de prdparation (D (;uGm~n6et al, FR). lnra, N o 2719480, FR. Protdines PRRSV recombinantes, kits de diagnostic el vaccins contenant ¢es protGinesPRRSV recombinantes {.1 Plana Dnran etal, ES). Cyanamid lberiea SA, N ° 2719845, ES. ... prot~ines produites dans un systbme d'expression de baculovirus, en utilis'ant des cultures Sf9 en tant qu'hdte permissifl.. Use of an enz)me for manufacturing an agent fl}r the treatment and/or prophylaxis of coccidiosis IMR Bedford etal, UKI. Finnfeeds International Ltd & The Minister of Agriculture, Fisheries & Food, N ° 681787, EP ... The carbohydrase may be a polysaccharidase such as a ,D,lanase or a cellulase eg fl-glucanase...

spore cultures of barley (M Saimenkalliomarttila et al, FI). Valtion Teknillinen Tutkimuskeskus & the inventors, N O WO 95/26628. PCT. Reduction of endogenous seed protein levels in plants (L Beach et al, US). Pioneer Hi-Bred International Inc, N ° wo 95/27068, PCT. Plant lysophosphatidic acid acyltransferases (HM Davies et al, US). Calgene 1nc & the inventors, N ° WO 95/27791, PCT. ... In addition, nucleic acid sequences encoding LPAAT protein regions are provided, and uses of such sequences for isolation of LPAAT genes from plants and for modification of plant triglyceride compositions are described. Rps2 genes and uses thereof (FM Ausubel et al, US). The General Hospital Corporation & The Regents of the University of Call. fornia, N ° WO 95/28478, PCZ Disclosed is substantially pure DNA encoding an Arabidopsis thaliana Rps2 polypeptide ....

liques qui les ¢ontiennent (JL Fanchore, etal, FR). Adir et Co, N° 2 719312, FR. ProtGine majeure de leishmanies, acide nucl~ique codant pour cette protdine et leurs applications iN Glaiehenhaus et aL FRI. CNRS, N ° 2719313, FR. Compositions and methods for sti. mulating mcgakaryocytc growth and differentiation ITD Bartley et al, US). Amgen lnc & the inventors, N ° WO 95/26746, PC1] Modified GAD. method fur manufacturing of modified GAD and a method to supply modified GAD and peptide (A Essen-M611er,SE). Synectics Medical AB & the inventor, N ° WO 95/27051, PCT. A modified GAD especially characterized by a substantially immunogenicity in connection with diabetes compared with a non-modified GAD... Afamin : a human serum albuminlike protein (HS Lichenstein et al, US), Amgen lnc & The Rockefeller University, N ° WO 95/27059, PCT.

\irus strain against pig pseudorabies and vaccines containing the Genetic sequences conferring said virus (B Lomniczi & F Meliota, , disease resistance in plants and uses Borrelia burgdorferi bacterin IJB therefor (GJ Lawrence et al, AU). HU & ITL Commonwealth Scienti~ and Indus. Korshus et al, US). Fatro SpA, N ° 682108, EP trial Research Organisation & the Solvay Animal Heath Inc & the inventors, N OWO 95/27504, PCT. Yaccines against hehninthi¢ para- inventors, N ° WO 95/29238, PCT. ... genetic sequences which confer or sites (DP Knox etaI, UK & US). Mallinckrodt Veterinary Inc & the otherwise facilitate disease resistance Interleukin-15 (KH Grabstein et al, in plants such as against rust and US). inventors, N ° WO 95/26402, PCT. lmmunex Corp, N O WO 95/27722. mildea:.. PCT. Nucleotide and amino acid Plant gene specifying acetyl eoensequences of canine herpesvirus gB, zyme a carboxylase and transfor- Peptides {JH Bo,aie & MJ Tyler, gC and gl) and uses therefor (E med plants containing same CAR AU). Paoletti & KJ Limhach. US). Luminis Pry Ltd& the inventors, N o Slabas et al, UK) Virogenetics Corp, N ° WO 95/26751, Zeneca Ltd& the inventors, N ° WO WO 95/27728. PCT.. PCT. 95/29246, PCZ Novel, biologically active peptides, known as Tryptophyllins L, RubelliHerpes+irus transform6s pour Regulatory element conferring dins, Dynastins, Uperins, Eucnemins exprimer gD in vitro (J-C Audonnet tapetum specificity (GA Huffman, and Frenatins, And also a new series et al, FR). US). of Caerin peptides, are extractable RhGne-M~rieux SA, N o 2719056, FR Pioneer Hi-Bred International Inc, N ° from the skin or glands of /?ogs... et WO 95/29248, PCT. WO 95/'2,9247, PCT. Some of the present peptides have ...L'invention concerne notamment les potent physiological activity, eg as herpksvirus aviaires, en particulier neurotransmitters, neuromodulators, MDV, et le virus VZV. wide spectrum antibiotics, antiviraI ,ANT agents and nematocidal agents. The peptides may also be used for food PRODUCTIONS PROT¢INESET PEPTIDES preservation.

VI~GI~TALES

Regeneration of green plants from protoplasts isolated from micro36

Nouveaux pseudopeptides de neurokinines, leur procGd6de prGparation et Its compositions pharmaceu-

New thindepsipeptide isolated from a marine actinomycete LIP Baz et at, ES).

Pharma Mar SA, N ° WO 95/27730, PCT. ... belonging to the family Micromonosporaceae... The compound and the fermentation broth demonslrate significant activiO, against several cancer cell lines. The compound also shows activi~' against several gram positive bacteria.

Superoxid¢ dismutase-4 {GL Yu el al, US). Human Genome Sciences Inc & the inventors, N o WO 95/27781, PCT. Peptides for rcduting or inhibiting bone resorption, angiogenesis and restenosis (S Cheng etaL US). La Jolla Cancer Research Foundation, N ° WO 95/28426, PC~ Cell-cycle regulatory proteins, and uses related thereto (DH Beach et at, US). Cold Spring Harbor Laboratory, N O WO 95/28483, PCT. Spider neurotoxins and method of producing the same (DR Bell el al, UK, RU & USL British Technology Group Ltd& the inventors, N ° WO 95/29235. PCT. Cardiotrophin and uses therefor (J Baker et al, US). Genentech Inc, N ° WO 95/29237, PG~. Angiostatin and method of use for inhibition of angiogenesis IMS O'Reilly etal, US). The Children's Medical Center Corp, N ° WO 95/29242, PCT. Mac-1 I-domain protein useful in blocking adhesion and migration of neutrophils (RI, Heinrikson et al, [!S). The Upjohn Co & the inventors, N ° WO 95/29243 PCT. An isoIated and pur(fied protein of the I-Domain from the human leukocyte fl2-integrin Mac-l, expressed in recombinant Escherichia colt as a soluble fusion protein with glutathione S-transferase (GST)... BIF2 complex proteins and uses thereof (J M Egly et al, FR). Association pour le d~veloppement de la recherche en gdngtique molgcu. laire, N ° WO 95/29245. PCT. BTF2 complex proteins, particularly proteins p44 and,o34, and the use thereoffor diagnosing DNA repair process deficiencies, are disclosed.

MACROMOLECULES Nouveaux complexes d'aeide nncldiqtw et de polymi~re,leur pro. c~d6 de prdparatimt et leur utili-

B I O F U T U R 152- J A N V I E R 1996

BREVETS in highly expressed monocot or &cot proteins.

sation pour la transfection de cel- 8-U-Merpeptidesare ident$ed, from four Plasmodium falciparum antilules (P Midouxetal, FR). IDM 1mmunoDesigned Molecules, gens, circumsporozoite protein,

agent for treafiny bone diseases, in particularfor inducingbone regeneration...

NC2719316,FR.

Biologicalinsect control xeot I,II) \Vindass,UK). Zeneca Ltd & the inventor, NCWO Plasmabiotal Lid, Aberdeen Univer- 95/26414PCI: sity& the inventors,N’ WO9Y27518, A recombinanthaculoGwfor use as

thrombospondin-relatedanonymous protein, spirozoitehepafocyte binding Oligosaccharidesde galactanessul- antigen and liver-stageantigen-l, as fates et compositioncosmt%iqueou actual or potential cytotoxic T lympharmaceutique g usage topique phocyte epitopesfor humanleucocyte externe contenant lesdits oligosac- antigen class I moleculesHLA-AZ, charides de galactanes sulfates (C HLA-B8,HLA-B7andHlA-B17...

Bodeau-Bellion8i D Fournier, FR). Simer,N”2719846,FR.

AlphavirusRNAas carrier for sactines (\V Dalemansef al, BE & SE).

Antibodies against E-selectin (RJ Owens& hlK Robinson,UK). Celltech Therapeutics Ltd & the

SmithKlineBeecham Biologicaki SA, Bioption AE & the inventors,NCWO 9327069,PCT

inventors,N”WO95/X403,PCT.

VIRUS

Protein tprosine kinase agonist antibodies(BDBennettet al, US). Genentech Inc, N” WO 9X7061. PCI:

T-lymphotropic primate virus L (PTLV-L)and its applications (JJ Desmvter& PF Gouhau,BE).

hpoptose inhibitor (P Krammer et Stiching Rega Vzw& the inventors, N”WO95/‘26405. PCT al, DE). Deutsches Krcbsforschungszentrum St@ung des OfSentZichenRechts & lmmunodeficiency recombinant poxvirus(E Paolettietal, US). the inventors,N”WO9X7735. PCC VirogeneticsCarp, N” WO95R7507, PCL

DIAGNOSTIC

Diagnosis.therapy and cellular and animal modelsfor diseasesassociated with mitochondrial defects (C Herrnstadt et al, US).

Isolation and characterization of a novel primate T-cell lgmphotropic virus and the use of this virus or components thereof in diagnostics assavsand Faccines(G Franchini et

AppliedGeneticsIne & the inventors, N”WO95/26973,PCT The present inventionrelates to genetic mutations in mitochondrial cytochrome c oxidase genes that segregate with ilizheimer‘sdisease (AD), diabetes mellitus,Parkinson’sdisease and other diseases of mitochondrial origin...

al, riS). The Governmentof the UnitedStates of America, Department of Health and Human Services& the inventors, N”WO9X29240,PCT

Recombinantpgpi methodsof preparation and use in diagnosis and therapy (G Ratti. ITI. BiocineSPA& the inventors,N” WO

Neurothrophin-6 : a new member of the neurothrophin family (RG Giitzet nl, DE). Max-P&k-Gesellschft zur Fiirderung der Wissenschaften EV & the

95l28487,PCT A new recombinantform of the plasmid-encodedproteinpgp3from C trachomatis,seropped...

VACCINS

MALADIES NEURODkGkNtRATIVES

inventors,N”WO95126363, PCT

Apoliprotein E polymorphismand treatment of Alzheimer’sdisease(J Poirier, CA).

Bone regeneration IS ibrdli UK).

ef al.

PCT. The present invention relates to an intraosseous injectable composition which comprises hvdrox~apatite an&or carbonated apatite and a biocompatible source of calcium ions wherein there is additionnallyprovided a hormone selectedfrom a bone morphogenic protein, HGH, IGF-I and 2 and TGF- and in that composition is in theformof a settable injectable liquid...

Human hone stimulatingfactor(CS Tam,C.4). Osteopharm Ltd & the inventor, N” wo 95l28172.PCL

THiRAPIESGiNIQUE ETCELLULAIRE

DETECTION .4ppareil de mesure pour le contr8le de la qualite hactiriologique de l’eau IN Santurette R G Rigaud,FRI. GIE Anjou Recherche, N” 2719905,

Geneticallymodifiedcellsfor use in FR et N”682244,El? transplantation (EM Egan 8i SC Procedurefor measuring hiodegraChappel,US). hilitv of a sample(hl Itivaara, Fl). DiacrinInc, N”WO9X7042, PCT. Valion Teknillinen Tutkimuskeskus

AlphaviruscDYAvectors(P Liljes- & the inventor,N”WO9X7795,PCT trSm 8rH Garoff,SE). Bioption AB & the inventors,N”WO Detectionand identificationof entcric pathogensIB Roll.1%). 95/27044, PCT University of

Hawaii, N” WO

PCI: ,-\n adenovirus supervector system 95n92261, 111’W Zhang &J Ruth. US). ln particular, this inventionrelates

Board of Regents & the Universityof TexasSystem,N”WO95127071, PCT An adenoviral super-vectorsystem is disclosed that is capable of expressing more than 7.5 kilobases qfketerologousDNAin a replicationdefectiveadenoviral vector...

to methodsand reagents,forthe specific detection and identificationof Salmonella and Shigella in environmental samples such as w#ater and sewage.

A.\V-mediateddeliver! of I)\-\ to cells of the nervous sestem (MG Kaplitt 8i 4lJ During. L%).

GtNIEGiNiTIQUE

The Rockefeller University& Yale University, N”WOY5LV493.PCT

?lulliple

MartinexR&DInc & the invent04N” wo 95l29257,PCL

Vaccinefor nontypable Haemophilus influenzae strain (G71’Zlotnick, US). American CyanamidCo, N”680765, EP

MALADIESOSSEUSES RFB retrovirus genome(J Schmidt, et al, DE 8i DK).

BIOPESTICIDES

Recombinant mgcohacterial yac- GSF-ForschungszentrumfiirUrnwelt Synthetic insecticidal crystal pround Gesundheit GmbH & the inven- tkin gene(MJ Adanget al, USI. tine (BRBloom et al, US). Mycogen Plant Science Znc, N” Whitehead Institutefor Biomedical tors,N”wo 9x27063,PC7: Research, N”681026,Efl Theinventionconcerns the complete 682115,EP gene sequence of the RFB provirus SyntheticBacillusthuringiensintoxin hlalaria peptides(AVHill et al, UK genome. According to the invention, genes designed to be expressed in & Ghl). RFB retrovirusand other osteoinduc- plants at a levei higher than natuIsis Innovation Ltd & the inventors, tive retrovirusesassociated therewith rally-occuringBt genesare pmvided. N”WO9X6982, PCT

BIOFWTUR

an insect control agent having a genome which comprises a polyhedrin gene and a heterologous gene which expresses an insecticidal protein, whereinthe polyhedringene and the heterologous gene are not under the control of the same promotei;and are located on the genome such that viralprogenyproduced by a recombinarioneventwith the wild-gpe baculoviruswhichare viable do not retain expression of both the polyhedrin gene and the heterologousgene.

152 - JANVIER

are used to develop a therapeutic

1996

These genes utilize codons preferred

of DNA,in particulal;for the cloning of “unclonable” DNAusing genetically engineeredhostcells are disclosed. Host cell organisms have been discovered that stabilize and inhibit rearrangement of DNA molecules

capable of forming non-standard secondary and tertiav structures. Organismsare engineered to contain 37

BREVETS at /fast one mutation whichinactivates homologousrecombinationand at least one mutationin a DNArepair pathw’ay...

exhibits significantly higher expression levels in human T cells than do conventional expression vectors conrainingviralpromorers.

Plamid Fector and its use for the production of heterologous proteins iG Frascotti & G Grandi. IT). EniricercheSPA,N”681027,Et!

ANALYSEDUGiNOME

A new plasmid vector operable in Escherichiacoliand Bacillussubtilis, comprising a synthetic promoter capable of directing wirhgreat efficiencythe expressionof the hetemlogous gene under its contml is described...

Selective amplification of target polynucleotidesequences(LJ Burg et al, US). Trusteesof Leland StanfordJunior University, No682120,EI! A method is providedfor multiplying

vage can take place. At each cycle the target sequence is shortened by one or more nucleotides untilthe nucleotide sequence of the target polynucleotide is determined...

Hibridization-ligation assays for the detectionnf specificnnclkicacid sequences (RA Martinelli & JC Arruda, US) CibaComingDiagnostics Corp& the inventors, N”WO9327078,PCT ... Thepreferred technique involves

Animal transgeniqne on chimh. rique el pro&dCde crihlagede pro. duits pharmaceutiques (H Le Monellic8i P Brulet,FR). hstilut Pasteur,N”682111, EII Peptide production as fusion pro-

usinga gene amplification technique tein in transgenicmammalmilk (IR blethods of producing effective (eg, PCRJ to multiply the gene Cottingham8; I (iarner. UK). recombinant serine protease inhi- sequence of interest and using a PPL Therapeutics(Scotland)Ltd & bitors and uses of these inhibitors hybridization-ligation detection theinventors, N”WO9X7782.PCT. (H Ruhin etal, USI. methodology,wherein the sequences .. The peptides are made as fusion The Trusteesof the Universityof of probes hybridized to the target proteins witha suitablefusion partner Pennsylvania &theinventors, N”WO sequence allow for separation and such as a-lactalbumin, which is a 95/X3422, PCT detection (eg, probes mightcontain a naturalmilk protein. Thefirsionpart,.. Compositionscapable of modula- combination of magnetic particles ner protein acts to promote secretion ting serineprotease activit);and use and acridiniumesters)to determinein sf the peptides and, at least in the of such compositions to regulate a specific sequenceis present. case of alactalbumin, allow a singleinflammatoryprocesses in cells are step purification based on speci’c DNAsequencing by stepsise liga- af&ity... A particular advantage of also provided. tion and cleavage(S Brenner,UK) producing peptides via this route, in Lynx Therapeutics Inc, N” WO additionto the obvious advantagesof I)\\ encoding brad!kinin Bl 95/27080, PCT. receptor(DLLinemeyeret al. US). high yield and biocompatibility,is Merck& Co Inc & the inventors,N” The inventionprovides a method 01 thatspec$c post-trantionalmodiJcawo 9328474,PCT nucleic acid sequence analysis based tions: such as carboxy terminal amion repeated cycles of ligation to and dation, can be performed in the Expression \eclor \rith non-viral cleavage of probes at the terminusoj mammary gland. promoter(A Xu et al, USI a targetpolynucleotide.At each such AlliancePharmaceuticalCarp& La cycle one or more terminal nucleo- u(1.31 galactosjltransferase negaJolla CancerResearchFoundation, tides are identified and one or more the ssine (RICV Baetscheret al. US N”WO28490,PCT nuckotides are removedfmm the end &UK). Thisexpressionvector containsthe qf the targetpolynucleotide,such that Biotransplant lnc, The GeneralHoshuman leukosialin promoter and further cycles of ligation and clea- pital Corporation,instituteof Child 38

9SR8412,PCC

Transgenicswinein which the normal expression of a( 1,3)galactosyltransferase is prevented in at least one organ of tissue type. The absence or Method for preparing template inactivation of this enzymeprevents DNAfrom cell cultures (GM Sathe the production of carbohydratemoieties having the distinctive terminal & SP O’Brien,US) epitope SmithKlineBeecham Corp & the GalalJGamp-aCIcNAc that is significantfactor in xenogeneinventorsNoWO95.8496,PC?Y a simple, rapid and reliable method tic, particular/y human, transplant for sequencing nucleic acid inserts rejectionofswinegrafts. directly from a piasmid DNA which comprises the steps of spinningdown DIVERS an overnight cell culture to obtain a pellet: resuspendingthe pellet; heating the resuspendedpellet and sepa- ProcedG et installation pour la rating the insoluble cell debris from nnmkrisationde celluleset microorthe DNA-containing supernatant, ganismes,notamment des produits wherebythe DNA-containing fraction alimentaircs ou dcs flnides hiolois useful as template DNAfor auto- giques(JC Bisconk, FR). mated sequencing. BiucomSA,N”2719602,FR

the numberof copies of a targetpolynucleotide sequence comprising a series of primer hybridization,extending, and denaturingsteps to provide \lethod for the permanent eapres. an intermediate double-stranded sion of glutamatereceptors(S Ster- DNAmoleculeconlaininga promoter rcr et al, AT& DE). sequence (throughthe use ofa promoBASFAC & the inventors,N”WO ter-sequence-containing primer) %%5403, PCZ incorporatedupstreamfrom the target sequence. The double-strandedDNA HighI!-purified recombinant intermediate is then used to grow relene transcriptaseiDL Kacianet multiple RNA copies of the target Detectionof mutation b> resollase ul. us ). sequence. The resulting RNAcopies cleavage IRG Cotton et al, r\ll & Gen-ProbeInc, N” WO 95127047, can be used as target sequences to DE1 PC1 AppliedTechnology GeneticsCarp,N” producefurther copies... WO9Y292.51. PCT. A plasmidfor expressionof Maloney Murine Leukemia Virus-derived Fluorescencepolarizationdetection reverse transcriptase in E coli cells of nucleic acid amplification (GT Nucleic acid mutation assays i GR Taylor.UK1 deficient in the expressionof indige- FYalkeret al, US) BectonDickinsonand Co,N”678581, St James’ and Seacroft University nousRNAseactivity... El? HospitalsNHSTrust& the inventor, (;ene coding for IgGFc-binding PCT A fluorescent/)) labelled oli- N”WO95/2925X, protein ihl \lorikawa, JP) godeognucleotide probe is converted ChugaiSeiyakuKabushikiKaisha, from single- to double-strandedform NoU’O9X27057, PCT in a target dependentmanner during ANIMAUX amplijicalionof the targetsequence... TRANSGtNIQUES

Cloning and expression of human GJIP s\ntase, its use in screening for inhibitors of human CMP svntbetase and inhibitors of human GI\IP yntase (L Lou 8r J Barnett, I’SI. Syntex(USA)Inc, N”WO95127789, PCT

Health & the inventors, N” WO

Culture and isolation of fetal cells form maternal peripheral blood (K Pavelkaefal, USI. Genzyme

Carp,

N” IV0 95126417.

PCT _._The culturedfetal cells can be used to determine fetal sex and to detect disease-causing

mutations

and chro-

mosomalabnormalitiesin a fetus.

Differentialexpansionof fetal stem cellsin the maternal circulationfor use in prenatal geneticanalysis (BP Alter. US). Board of Regents,the Universityof TexasSystem,M”WO9X6507, PCI: Biolilmdevicefor the monitoringof microbialdisturbancesin industrial processwatersIP \:%itlnen, Fl). Kemira Chemicals @, N” WO 9x7039,

PCT.

Freeze-driedcompositionscomprising RNA(?lH Ilylcn cl al, NLI. Ak o NobelNV& the inventors f A’” W;9X772,, PCI:

Process for producing dendritic cells, cells thus produced and container for carrying out this process(I, Kanschct rrl,DE). Klinikumder Albert-Ludwig-Universit&Freiburg& the inventors, N”WO 9328479,PC?:

Cetk ruhrique est ktablie encoliaborati~ avtx lM_itatnatiwaldelap+upri& indashielle, et averb coaseils d’autres experts qaaada&es

E&eve&peuvent be obtenues il1’Inpi (26 his, rue de Saint-P&ersbourg, 75800Paris Q&xOS)& descopies peuveat &efoamies s11l simple demaade &a 11% tarifsenvigueul

BIOFUTUR

152 - JANVIER

1996