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mass spectrometry in medicine and pharmacology
366
characterization of metallic pollutants. There is also a useful discussion of relevant legislation in the European Community and North America. This book is recommended general reading for any analytical chemist with an interest in the environment. Hugh D. Crone, Chemicals and Society - a Guide to the New Chemical Age. Cambridge University Press, Cambridge, 1986 (ISBN 0-521-30869-O (hardback), O-521-31359-7 (paperback) ). x + 246 pp. Price g25.00 (hardback), &X95 (paperback). In spite of the great benefits of the products of modern chemical industry, the media often seem to equate the word “chemical” with “pollution” and “poisoning”. It is seldom pointed out how difficult it can be to decide whether a substance is beneficial or harmful. This book introduces the ways in which scientists evaluate scientifically the effects of chemicals upon people and their environment. Early chapters discuss toxicity and dosage, and the routes by which chemicals enter and leave living systems. There then follows a series of chapters covering topics such as Drugs, Chemical Warfare, Herbicides, Synthetic Chemicals in the Environment, and Cancer. Each chapter contains many examples, and the complexity of most problems is emphasised. This book is written for professional chemists who have not studied toxicology. It is easy to read and is recommended as background reading for analytical chemists. J.R. Chipperfield A. Benninghoven, A.M. Huber and H.W. Werner, Secondary Ion Mass Spectrometry (SIMS VI). Wiley, Chichester, 1988 (ISBN O-471-91832-6). xxvii + 1078 pp. Price di75.00. The importance of SIMS in modern analytical chemistry, and its accelerating growth, is very evident from these Proceedings of the Sixth International Conference on SIMS held at Versailles in September 1987. The contents are summaries in camera-ready copy of over 230 papers, 4 pages each for submitted papers, with a little more for invited lectures. They are classified under Fundamentals, Instrumentation, Quantification, Ion Imaging, Depth Profiling, Combined Techniques, Organic, Materials, Applications in Electronics, Biology, Geology and Metallurgy, Post-ionization, and Surface Studies. The quality of the production is high, and the editors and publishers are to be congratulated on producing such a large report so quickly. Halvor Jaeger (Ed. ), Capillary Gas Chromatography/Mass Spectrometry in Medicine and Pharmacology. Hiithig, Heidelberg, 1987 (ISBN 3-7785-1375-3). xiii + 309 pp. Price DM 108.00.
367
Capillary gas chromatography/mass spectrometry provides extremely high resolution, highly sensitive analyses, and nowhere are these properties displayed to better advantage than in the analysis of biomedical samples. This book is an account of a workshop held in Neu-Ulm in May 1985, which, after a brief account of advances in GC, describes a wide range of applications by various authors of GC/MS to analysis for drugs and metabolites, ergotamine, organic acids, steroids, nitroglycerine and applications to clinical chemistry, detection of solventemia and bioavailability. There is a lot of practical information included in these chapters, and there are specific sections devoted to automation and automatic optimization of GC, and to sample preparation. The editor has been very effective in uniting the various contributions into a clear expose of the subject. K. Rozman Amsterdam, 154.00.
and 0. Hanninen (Eds.), Gastrointestinal Toxicology. Elsevier, 1986 (ISBN o-444-90424-7). xxiv + 606 pp. Price Dfl. 385.OO/US$
This is a book of 17 chapters, organized by numerous authors, which has the primary goal of creating “a balanced view of the gastrointestinal tract as a target organ of toxicity”. This balance has certainly been achieved, in a very comprehensive fashion. It is arranged in five sections, covering function, biochemistry and immunology, morphology and lesions, classes of toxic substances (foods, additives, contaminants, drugs, metals, and industrial and environmental chemicals), and applications (clinical and veterinary especially of ruminants). The book concludes with an extensive (64 pp.) subject index. As much of the information on toxin concentration relies on very sensitive analytical determinations, analytical scientists will be fascinated by the consequences of their measurements. Most importantly, however, the book provides in a single volume, an up-to-date, wide-ranging account of a most important toxicological area. W.R. Laing (Ed.), Analytical Chemistry Instrumentation. Lewis Publishers, Chelsea, MI, 1986 (ISBN O-87371-053-3). xi+ 362 pp. Price $45.95. These are the proceedings of the 28th Conference on Analytical Chemistry in Energy Technology, Knoxville, TN, October 1985. The book contains, in camera-ready copy, 48 papers mainly on mass spectrometry, including ICP/ MS, nuclear analysis (especially of plutonium) and fuel technology, chemometrics, and environmental analysis, with small sections on Fourier transform spectrometry and automation. As has often been stated in the past, there seems to be little permanent value in producing collections of papers on such a variety of topics in this way, and the present publication, although well produced, is no exception.
characterization of metallic pollutants. There is also a useful discussion of relevant legislation in the European Community and North America. This book is recommended general reading for any analytical chemist with an interest in the environment. Hugh D. Crone, Chemicals and Society - a Guide to the New Chemical Age. Cambridge University Press, Cambridge, 1986 (ISBN 0-521-30869-O (hardback), O-521-31359-7 (paperback) ). x + 246 pp. Price g25.00 (hardback), &X95 (paperback). In spite of the great benefits of the products of modern chemical industry, the media often seem to equate the word “chemical” with “pollution” and “poisoning”. It is seldom pointed out how difficult it can be to decide whether a substance is beneficial or harmful. This book introduces the ways in which scientists evaluate scientifically the effects of chemicals upon people and their environment. Early chapters discuss toxicity and dosage, and the routes by which chemicals enter and leave living systems. There then follows a series of chapters covering topics such as Drugs, Chemical Warfare, Herbicides, Synthetic Chemicals in the Environment, and Cancer. Each chapter contains many examples, and the complexity of most problems is emphasised. This book is written for professional chemists who have not studied toxicology. It is easy to read and is recommended as background reading for analytical chemists. J.R. Chipperfield A. Benninghoven, A.M. Huber and H.W. Werner, Secondary Ion Mass Spectrometry (SIMS VI). Wiley, Chichester, 1988 (ISBN O-471-91832-6). xxvii + 1078 pp. Price di75.00. The importance of SIMS in modern analytical chemistry, and its accelerating growth, is very evident from these Proceedings of the Sixth International Conference on SIMS held at Versailles in September 1987. The contents are summaries in camera-ready copy of over 230 papers, 4 pages each for submitted papers, with a little more for invited lectures. They are classified under Fundamentals, Instrumentation, Quantification, Ion Imaging, Depth Profiling, Combined Techniques, Organic, Materials, Applications in Electronics, Biology, Geology and Metallurgy, Post-ionization, and Surface Studies. The quality of the production is high, and the editors and publishers are to be congratulated on producing such a large report so quickly. Halvor Jaeger (Ed. ), Capillary Gas Chromatography/Mass Spectrometry in Medicine and Pharmacology. Hiithig, Heidelberg, 1987 (ISBN 3-7785-1375-3). xiii + 309 pp. Price DM 108.00.
367
Capillary gas chromatography/mass spectrometry provides extremely high resolution, highly sensitive analyses, and nowhere are these properties displayed to better advantage than in the analysis of biomedical samples. This book is an account of a workshop held in Neu-Ulm in May 1985, which, after a brief account of advances in GC, describes a wide range of applications by various authors of GC/MS to analysis for drugs and metabolites, ergotamine, organic acids, steroids, nitroglycerine and applications to clinical chemistry, detection of solventemia and bioavailability. There is a lot of practical information included in these chapters, and there are specific sections devoted to automation and automatic optimization of GC, and to sample preparation. The editor has been very effective in uniting the various contributions into a clear expose of the subject. K. Rozman Amsterdam, 154.00.
and 0. Hanninen (Eds.), Gastrointestinal Toxicology. Elsevier, 1986 (ISBN o-444-90424-7). xxiv + 606 pp. Price Dfl. 385.OO/US$
This is a book of 17 chapters, organized by numerous authors, which has the primary goal of creating “a balanced view of the gastrointestinal tract as a target organ of toxicity”. This balance has certainly been achieved, in a very comprehensive fashion. It is arranged in five sections, covering function, biochemistry and immunology, morphology and lesions, classes of toxic substances (foods, additives, contaminants, drugs, metals, and industrial and environmental chemicals), and applications (clinical and veterinary especially of ruminants). The book concludes with an extensive (64 pp.) subject index. As much of the information on toxin concentration relies on very sensitive analytical determinations, analytical scientists will be fascinated by the consequences of their measurements. Most importantly, however, the book provides in a single volume, an up-to-date, wide-ranging account of a most important toxicological area. W.R. Laing (Ed.), Analytical Chemistry Instrumentation. Lewis Publishers, Chelsea, MI, 1986 (ISBN O-87371-053-3). xi+ 362 pp. Price $45.95. These are the proceedings of the 28th Conference on Analytical Chemistry in Energy Technology, Knoxville, TN, October 1985. The book contains, in camera-ready copy, 48 papers mainly on mass spectrometry, including ICP/ MS, nuclear analysis (especially of plutonium) and fuel technology, chemometrics, and environmental analysis, with small sections on Fourier transform spectrometry and automation. As has often been stated in the past, there seems to be little permanent value in producing collections of papers on such a variety of topics in this way, and the present publication, although well produced, is no exception.