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Mass Spectrometry. Techniques and Applications of Tandem Mass Spectrometry
International Journal of Mass Spectrometry and Ion Processes, 93 (1989) 265-266
265
Elsevier Science Publishers B.V., Amsterdam - Printed in The Netherlands
Book Review
Mass Spectromet~ / Mass Spectromet~. Techniques and A~p~~cut~ons of Tandem Mass Spectrometry, by Kenneth L. Busch, Gary L. Glish and Scott A. McLuckey, VCH Publishers, Inc., New York, 1988, US$75, 333 pp., ISBN O-89573-280-7. Tandem mass spectrometry continues to gain importance and this timely book will further facilitate its progress. Although subtitled Techniques and Applications the book actually has three main components, one of which is a treatment of the fundamental phenomena which underlie the analytical methodology. Readers of this journal should find the treatment of the mechanism of collisional activation, internal energy deposition, charge permutation reactions and collision dynamics of particular interest. This section is similar in scope to Levsen’s beautiful Fundamental Aspects of Organic Mass Spectrometry, which is unfortunately out of print. Like Levsen’s earlier book, there are plenty of examples of ion structural studies and unimolecular dissociation mechanisms against which the various methods are pitched. Instrumentation for MS/MS is treated in a concise fashion with clear descriptions of all the major configurations used to obtain this type of data and the limitations of each. Ion traps and ion cyclotron resonance instrumentation is included along with quadrupoles, sectors and a strong presentation on hybrid instruments. In this section, as in other parts of the book, the authors provide basic background material which is not unique to tandem mass spectrometry. For example, the common ionization methods are reviewed. This feature makes the book of interest as a text in a graduate course on mass spectrometry. The presentation of the applications of tandem mass spectrometry is comprehensive in its coverage of the types of compounds and subject areas which have been tackled. Biological compounds, pharmaceuticals, natural products, petroleum and fuels, industrial products, and forensics are all treated with numerous recent examples. The compactness of presentation is reminiscent of the biennial reviews which Burlingame and his coauthors prepare for Analytical Chemistry and in topical coverage the applications chapters represent an updated treatment of the type to be found in McLaffery’s book Tandem Mass Spectrometry. To summarize, this book is eminently readable, current, exhaustively referenced, and largely free from errors. The illustrations are well chosen
266
although a few are poorly reproduced. The three authors have produced a consistent, well-organized text which should become a standard reference on this important topic. R.G. COOKS
Chemistry Department, Purdue University, West Lafayette, IN 47907 U.S.A.
265
Elsevier Science Publishers B.V., Amsterdam - Printed in The Netherlands
Book Review
Mass Spectromet~ / Mass Spectromet~. Techniques and A~p~~cut~ons of Tandem Mass Spectrometry, by Kenneth L. Busch, Gary L. Glish and Scott A. McLuckey, VCH Publishers, Inc., New York, 1988, US$75, 333 pp., ISBN O-89573-280-7. Tandem mass spectrometry continues to gain importance and this timely book will further facilitate its progress. Although subtitled Techniques and Applications the book actually has three main components, one of which is a treatment of the fundamental phenomena which underlie the analytical methodology. Readers of this journal should find the treatment of the mechanism of collisional activation, internal energy deposition, charge permutation reactions and collision dynamics of particular interest. This section is similar in scope to Levsen’s beautiful Fundamental Aspects of Organic Mass Spectrometry, which is unfortunately out of print. Like Levsen’s earlier book, there are plenty of examples of ion structural studies and unimolecular dissociation mechanisms against which the various methods are pitched. Instrumentation for MS/MS is treated in a concise fashion with clear descriptions of all the major configurations used to obtain this type of data and the limitations of each. Ion traps and ion cyclotron resonance instrumentation is included along with quadrupoles, sectors and a strong presentation on hybrid instruments. In this section, as in other parts of the book, the authors provide basic background material which is not unique to tandem mass spectrometry. For example, the common ionization methods are reviewed. This feature makes the book of interest as a text in a graduate course on mass spectrometry. The presentation of the applications of tandem mass spectrometry is comprehensive in its coverage of the types of compounds and subject areas which have been tackled. Biological compounds, pharmaceuticals, natural products, petroleum and fuels, industrial products, and forensics are all treated with numerous recent examples. The compactness of presentation is reminiscent of the biennial reviews which Burlingame and his coauthors prepare for Analytical Chemistry and in topical coverage the applications chapters represent an updated treatment of the type to be found in McLaffery’s book Tandem Mass Spectrometry. To summarize, this book is eminently readable, current, exhaustively referenced, and largely free from errors. The illustrations are well chosen
266
although a few are poorly reproduced. The three authors have produced a consistent, well-organized text which should become a standard reference on this important topic. R.G. COOKS
Chemistry Department, Purdue University, West Lafayette, IN 47907 U.S.A.