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Cell Proliferation in Lymphornas
Pathology (1994), 26, pp. 78-79
BOOK REVIEWS
Fine Needle Aspiration of Palpable Masses. MICHAEL W. STANLEY AND TORSTEN LOWHAGEN. Butterworth-Heinemann, Boston, London, Oxford, Singapore, Sydney, Toronto, Wellington, 1993. ISBN 0-7506-9455, pp. xv+ 156, $145.00. This book differs from all other textbooks on fine needle aspiration in that it focuses almost exclusively on the technical aspects of the procedure and the problems and possible solutions encountered in various clinical situations. The false negative rate is the source of most of the errors in fine needle aspirates as a result of inadequate sampling or poorly prepared smears. The inherent nature of a lesion such as dense sclerosis can result in a non-representative or inadequate sample. The authors give detailed and illustrated accounts for optimizing the techniques and so minimizing errors. Illustrations in black and white as well as 19 high quality colour plates of various lesions from different sites are utilized to demonstrate the technical aspects discussed in the text. The book comprises 156 pages and is basically divided into 3 sections. The first section addresses the different basic techniques of fine needle aspiration. This includes the equipment and various sizes and length of needles for different lesions in a variety of body sites. Smearing techniques as applied to solid, fluid or blood-stained aspirates are extensively illustrated. Appropriate use of different fixatives and staining procedures are addressed. The middle section is clinically oriented focusing on patient communication and clinical techniques as applied to particular body sites. The clinico-pathological correlation when reporting fine-needle aspirates is emphasized and the medico-Iegal implications are highlighted. The final chapter uses 10 case studies to illustrate and emphasize salient points raised in the text. This book will be of immense value to experienced clinicians and pathologists already performing fine needle biopsies as well as those who are about to embark on the technique.
M. Greenberg Eye and Ear. Edited by T. C. JONES, U. MOHR AND R. D. HUNT. Springer Verlag, Berlin, Heidelberg, New York, London, Paris, Tokyo, Hong Kong, Barcelona, Budapest, 1991. ISBN 0-387-54044-X, pp. xii + 170, DM 270. Comparison of information available on similar lesions in man and other species is valuable as a means to gain broader understanding of the processes involved. Illustrations are an especially important means of non-verbal communication, especially among pathologists, and this volume contains good quality black and white light and electron micrographs (TEM and SEM). The authors have endeavoured to include important lesions which a pathologist might encounter in studies involving the rat, mouse, or hamster. Out of 158 pages, 140 are devoted to the eye and 18 to the ear. The section on the eye includes eornea, uvea, lens, retina and lacrimal glands. Adenoma and carcinoma of the auditory sebaceous glands, auricular chondritis and aural cholesteatoma in gerbil are parts of the section on the ear. I found chapters on inherited retinal degeneration (RCS rat) and on experimental retinoblastoma most interesting. I learned about adenovirus 12 induced retinoblastoma and that this tumor can be produced in rats by intraocular transplantation of adenovirus 12 transformed cells. One criticism involves differential diagnosis of calcification of the cornea (band keratopathy) which leaves out a commonly missed climatic droplet keratopathy (hyaline degeneration) but includes edema, lipid material, or inflammatory infiltrates which may not need to be considered. Only in a few studies in rats have intraocular uveal
melanomas been studied. Sarcoma not otherwise specified was the most frequently diagnosed intraocular neoplasm. It is not appreciated that medulloepithelioma belongs to adenomas and carcinomas of the ciliary epithelium. Two of the chapters on the lens come to the rather unfruitful conclusion that the histopathology of cataract is non-specific, representing a common tissue response to a variety of insults. Clinical history, latency, location, and cytopathologic features may be suggestive but rarely diagnostic of a particular type of cataract. In Fig. 71 (light induced retinal degeneration) the outer and not the inner nuclear layer appears to be reduced in thickness. And it is no news that retinal changes in toxic retinopathy may also occur secondary to glaucoma, retinal edema, retinal hemorrhage and retinal vascular disturbances, including those induced by diabetogenic agents. A comprehensive index is provided to enhance the use of the volume as a reference which could find its place in the libraries of Eye and Ear Hospitals.
Marijan Filipic Cell Proliferation in Lymphomas. Edited by JOHN CROCKER. Blackwell Scientific Publications, Oxford, London, Edinburgh, Boston, Melbourne, Paris, Berlin, Vienna, 1993. ISBN 0-632-02925-0, pp. xvi + 192, A$205.00. This is a useful book for those attempting to keep up with newer methods in the study of lymphoma and, for that matter, other tumors. As indicated by the title, the main concern is the measurement of cell proliferation and cell cycling in an attempt to predict prognosis of lymphomas on an individual basis more accurately than is possible by classification and grading alone. Some of the topics covered include mitosis counting, apoptosis, oncogenes including c-myc and bcl-2, growth factors, 3H-thymidine labelling, DNA flow cytometry - including using paraffin embedded material, immunohistochemistry with Ki 67, PCNA and other monoclonal antibodies, nucleolar organizer regions and fibrillar centres. Recipes are not given, but the theory, applications and some of the problems of the methodologies are explored, and references are given. The 9 papers in this volume tend to give emphasis to the interests of the authors of each particular chapter. As such, there are some useful insights into a much broader area than the title of the book would suggest. For example, there is discussion of the problems of lymphoma classification (the Kiel classification is preferred), gene rearrangements, determination of light chain restriction by in situ hybridization of mRNA, B lymphocyte proliferation in the immune response, and even leukemia kinetics. While this small book is not always easy to read, I found it a useful reservoir of up-to-date information about lymphoma biology which is also applicable to other areas of pathology. Jennifer Turner
Neuropathology and Ophthalmologic Pathology of the Acquired Immunodeficiency Syndrome. UMBERTO DE GIROLAMI, THOMAS W. SMITH. DOMINIQUE HENIN AND JEAN.JACQUES HAUW. ButterworthHeinemann, Boston. London, Oxford, Singapore, Sydney, Toronto, Wellington. ISBN 0-7506-9239-1, pp. ix+ 165, A$247.00. The authors' studies on this topic have been reported previously. They have collected the best illustrations of these lesions from their files, added a very brief descriptive text, and selected a few references to highlight each lesion to create a monograph designed as a color atlas to illustrate
BOOK REVIEWS
Fine Needle Aspiration of Palpable Masses. MICHAEL W. STANLEY AND TORSTEN LOWHAGEN. Butterworth-Heinemann, Boston, London, Oxford, Singapore, Sydney, Toronto, Wellington, 1993. ISBN 0-7506-9455, pp. xv+ 156, $145.00. This book differs from all other textbooks on fine needle aspiration in that it focuses almost exclusively on the technical aspects of the procedure and the problems and possible solutions encountered in various clinical situations. The false negative rate is the source of most of the errors in fine needle aspirates as a result of inadequate sampling or poorly prepared smears. The inherent nature of a lesion such as dense sclerosis can result in a non-representative or inadequate sample. The authors give detailed and illustrated accounts for optimizing the techniques and so minimizing errors. Illustrations in black and white as well as 19 high quality colour plates of various lesions from different sites are utilized to demonstrate the technical aspects discussed in the text. The book comprises 156 pages and is basically divided into 3 sections. The first section addresses the different basic techniques of fine needle aspiration. This includes the equipment and various sizes and length of needles for different lesions in a variety of body sites. Smearing techniques as applied to solid, fluid or blood-stained aspirates are extensively illustrated. Appropriate use of different fixatives and staining procedures are addressed. The middle section is clinically oriented focusing on patient communication and clinical techniques as applied to particular body sites. The clinico-pathological correlation when reporting fine-needle aspirates is emphasized and the medico-Iegal implications are highlighted. The final chapter uses 10 case studies to illustrate and emphasize salient points raised in the text. This book will be of immense value to experienced clinicians and pathologists already performing fine needle biopsies as well as those who are about to embark on the technique.
M. Greenberg Eye and Ear. Edited by T. C. JONES, U. MOHR AND R. D. HUNT. Springer Verlag, Berlin, Heidelberg, New York, London, Paris, Tokyo, Hong Kong, Barcelona, Budapest, 1991. ISBN 0-387-54044-X, pp. xii + 170, DM 270. Comparison of information available on similar lesions in man and other species is valuable as a means to gain broader understanding of the processes involved. Illustrations are an especially important means of non-verbal communication, especially among pathologists, and this volume contains good quality black and white light and electron micrographs (TEM and SEM). The authors have endeavoured to include important lesions which a pathologist might encounter in studies involving the rat, mouse, or hamster. Out of 158 pages, 140 are devoted to the eye and 18 to the ear. The section on the eye includes eornea, uvea, lens, retina and lacrimal glands. Adenoma and carcinoma of the auditory sebaceous glands, auricular chondritis and aural cholesteatoma in gerbil are parts of the section on the ear. I found chapters on inherited retinal degeneration (RCS rat) and on experimental retinoblastoma most interesting. I learned about adenovirus 12 induced retinoblastoma and that this tumor can be produced in rats by intraocular transplantation of adenovirus 12 transformed cells. One criticism involves differential diagnosis of calcification of the cornea (band keratopathy) which leaves out a commonly missed climatic droplet keratopathy (hyaline degeneration) but includes edema, lipid material, or inflammatory infiltrates which may not need to be considered. Only in a few studies in rats have intraocular uveal
melanomas been studied. Sarcoma not otherwise specified was the most frequently diagnosed intraocular neoplasm. It is not appreciated that medulloepithelioma belongs to adenomas and carcinomas of the ciliary epithelium. Two of the chapters on the lens come to the rather unfruitful conclusion that the histopathology of cataract is non-specific, representing a common tissue response to a variety of insults. Clinical history, latency, location, and cytopathologic features may be suggestive but rarely diagnostic of a particular type of cataract. In Fig. 71 (light induced retinal degeneration) the outer and not the inner nuclear layer appears to be reduced in thickness. And it is no news that retinal changes in toxic retinopathy may also occur secondary to glaucoma, retinal edema, retinal hemorrhage and retinal vascular disturbances, including those induced by diabetogenic agents. A comprehensive index is provided to enhance the use of the volume as a reference which could find its place in the libraries of Eye and Ear Hospitals.
Marijan Filipic Cell Proliferation in Lymphomas. Edited by JOHN CROCKER. Blackwell Scientific Publications, Oxford, London, Edinburgh, Boston, Melbourne, Paris, Berlin, Vienna, 1993. ISBN 0-632-02925-0, pp. xvi + 192, A$205.00. This is a useful book for those attempting to keep up with newer methods in the study of lymphoma and, for that matter, other tumors. As indicated by the title, the main concern is the measurement of cell proliferation and cell cycling in an attempt to predict prognosis of lymphomas on an individual basis more accurately than is possible by classification and grading alone. Some of the topics covered include mitosis counting, apoptosis, oncogenes including c-myc and bcl-2, growth factors, 3H-thymidine labelling, DNA flow cytometry - including using paraffin embedded material, immunohistochemistry with Ki 67, PCNA and other monoclonal antibodies, nucleolar organizer regions and fibrillar centres. Recipes are not given, but the theory, applications and some of the problems of the methodologies are explored, and references are given. The 9 papers in this volume tend to give emphasis to the interests of the authors of each particular chapter. As such, there are some useful insights into a much broader area than the title of the book would suggest. For example, there is discussion of the problems of lymphoma classification (the Kiel classification is preferred), gene rearrangements, determination of light chain restriction by in situ hybridization of mRNA, B lymphocyte proliferation in the immune response, and even leukemia kinetics. While this small book is not always easy to read, I found it a useful reservoir of up-to-date information about lymphoma biology which is also applicable to other areas of pathology. Jennifer Turner
Neuropathology and Ophthalmologic Pathology of the Acquired Immunodeficiency Syndrome. UMBERTO DE GIROLAMI, THOMAS W. SMITH. DOMINIQUE HENIN AND JEAN.JACQUES HAUW. ButterworthHeinemann, Boston. London, Oxford, Singapore, Sydney, Toronto, Wellington. ISBN 0-7506-9239-1, pp. ix+ 165, A$247.00. The authors' studies on this topic have been reported previously. They have collected the best illustrations of these lesions from their files, added a very brief descriptive text, and selected a few references to highlight each lesion to create a monograph designed as a color atlas to illustrate