CLINICAL AND MORPHOLOGIC PROFILE OF ORAL TONGUE SQUAMOUS CELL CARCINOMA: A RETROSPECTIVE STUDY

OOOO Volume 129, Number 1 alterations, the lips was the most affected region (52.50%), followed by the tongue (41.66%). Mouth lesions included ulcers, scaling, labial dryness, swelling, and traumatic lesions. No association was found between nosocomial pneumonia and oral lesions or oral hygiene. Conclusions: The results showed that, although there was no association between nosocomial pneumonia and oral changes, the alterations that affect the mouth have great relevance in the quality of life of the patients in ICUs. This data reinforces the importance of the presence of a dentist to support these patients. Support: FAPEMIG.

BDNF/TRKB PATHWAY IN SALIVARY GLAND CARCINOMAS. VIVIAN PETERSEN WAGNER, VIRGILIO GONZALES ZANELLA, CINTIA CORREA, MARINEZ BIZARRO BARRA, FELIPE PAIVA FONSECA, MANOELA DOMINGUES MARTINS and, PABLO AGUSTIN VARGAS Objectives: To evaluate the prognostic value of the brain-derived neurotrophic factor (BDNF), its tropomyosin receptor kinase B (TrkB), and 2 downstream targets of TrkB activation in salivary gland carcinomas (SGCs). Study Design: Immunohistochemistry was preformed in 128 cases of SGC using antibodies against BDNF, phosphoTrkB, phospho-Akt, and phospho-S6. The slides were scanned and analyzed using the Aperio Scanscope CS Slide Scanner. Results: BDNF, pTrkB, and pS6 were more expressed in adenoid cystic carcinoma (ACC) compared to mucoepidermoid carcinoma. In ACC, BDNF expression was associated with the presence of perineural invasion. Carcinoma ex-pleomorphic adenoma (CaExAP), the tumor with the worst prognosis in this study, also demonstrated an elevated expression of BDNF. However, BDNF/TrkB pathway immunoexpression was not associated with clinical outcomes. A direct correlation was observed between BDNF, pTrkB, pAkt, and pS6 expression. The colocalization of BDNF and pTrkB suggest an autocrine mechanism of this pathway in these malignancies. Conclusions: Our results indicate that the BDNF/TrkB pathway is more expressed in some histologic types of SGC and might be associated with aggressive behaviors. Yet, these markers had no prognostic value in the present study.

CLINICAL AND MORPHOLOGIC PROFILE OF ORAL TONGUE SQUAMOUS CELL CARCINOMA: A RETROSPECTIVE STUDY. CARLA MOSCONI, JULIE ANE MARIA GONCALVES, ¸ e FONSECA SILVA, POLLIANNA MUNIZ RICARDO NATA  ALVES, NADIA DO LAGO COSTA, ELISMAURO FRANCISCO DE MENDONCA ¸ and, ALINE CARVALHO BATISTA Objectives: Oral tongue squamous cell carcinoma (OTSCC) is a malignant neoplasm that is quite aggressive with a poor prognosis. Therefore, this study described clinicopathologic characteristics of a series of cases of OTSCC. Study Design: Observational and cross-sectional research. Sample consisted of 76 cases of OTSCC diagnosed in an oncology referral hospital, within a 16-year period (2000 to 2016). Clinical characteristics of patients (age, sex, and tobacco or alcohol habits, treatment, and survival) and lesions (tumor size, locoregional metastasis, distant metastasis, clinical stage,

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and recurrence) were obtained from medical records. Morphologic analysis was based on the World Health Organization (2017). Statistical analysis was descriptive. Results: Mean age of patients was 57.24 years. OTSCC was more frequent in males (n = 53; 69.73%), associated with tobacco or alcohol habits (n = 54; 71.05%), and tumor size T3/T4 (n = 42; 55.26%). The most recommended treatment was surgery associated radiotherapy and chemotherapy (n = 37; 48.68%). Local and distant metastasis occurred in 56.57% (n = 43) and 10.52% (n = 8), respectively. Advanced clinical stages III/IV (n = 54; 71.05%) were predominant. OTSCC without recurrence was higher (n = 61; 80.26%). Overall survival was § 51.47 months. Conclusions: The results showed that OTSCC is more common in smokers and drinkers of the male sex, and the latter diagnosis can be responsible for lower survival of these patients.

TRISMUS: A LATE COMPLICATION OF HEAD AND NECK RADIOTHERAPY. VICTOR DE MELLO PALMA, ELOISA BARBIERI  ELIS SOLDERA, GABRIELA BARBIERI ORTIGARA, RIELI SCHULZ, LAURA BONZANINI, CRISTIANE CADEMARTORI DANESI and, KIVIA LINHARES FERRAZZO Objective: To investigate trismus prevalence and associated factors in patients with head and neck cancers treated with radiotherapy. Study Design: This cross-sectional study evaluated 86 patients with head and neck cancers with treatment finished for at least 3 months. During evaluation, the patients were questioned about the difficulty of opening the mouth before the antineoplastic treatment. The mouth opening was performed with a millimeter ruler and trismus was considered as an interincisal mouth opening smaller than 35 mm. Characteristics such as tumor location, staging, radiation dose, and type of treatment were obtained from medical records. Results: Half of the patients studied presented with trismus after radiotherapy, with a mean mouth opening of 24.81 § 6.06 mm. Of these, 25.6% (P = .002) reported having difficulty in opening their mouths before the antineoplastic treatment. Patients with primary tumor in mouth and oropharynx had more trismus than those in the hypopharynx and larynx (P = .008); there was no association of trismus with tumor staging, dose, or type of treatment. Conclusions: Trismus had a high prevalence and is an important late complication of radiotherapy in the head and neck.

PREVALENCE OF STAFNE BONE DEFECT BY RADIOGRAPHIC EVALUATION: A STUDY FROM 3 CENTERS IN BRAZIL. ANA CAROLINA MACEDO DA SILVA DIAS, AMANDA KATARINNY GOES GONZAGA, ISRAEL LEAL CAVALCANTE, PATRICIA TEIXEIRA DE OLIVEIRA, RENATA CORDEIRO TEIXEIRA MEDEIROS, DEBORAH QUEIROZ FREITAS and, ANA MIRYAM COSTA DE MEDEIROS Objective: To investigate the prevalence of the Stafne bone defect (SBD) in the Brazilian population and to describe the clinical and radiographic characteristics of detected cases. Study Design: A retrospective and observational study in 17,180 panoramic radiographs of patients with previous