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Clinicopathological characteristics and outcomes of squamous cell carcinoma of the tongue in different age groups
298 4–5%. The early detection of high malignant transformation in OPMD patients is very import. Methods: Paired oral cancer/OPMD surgical specimens were obtained. Gene analysis of exomes was done by next generation sequencing, (NGS). Results: The gene mutation rate was increased in the progression of OPMD to oral cancer. The chromosome 4 and 17 had more mutations in oral cancer specimens. Positive correlation of gene mutation and malignant transformation of OPMD was found. Conclusion: Gene mutation was increased in the transformation of OPMD to oral cancer. Our study might be useful to develop chemical prevention agent to prevent malignant transformation in oral pre-cancer lesions. http://dx.doi.org/10.1016/j.ijom.2017.02.1001 Clinicopathological characteristics and outcomes of squamous cell carcinoma of the tongue in different age groups
maxilla and mandible involved femur, ribs and skull. The clinical features, laboratory investigations, pathological characteristics, imaging findings and treatment were retrospectively analysed. Findings: Both patients showed weight loss, fatigue, anorexia, nausea, pain and decreased bone density, high levels of serum calcium, alkaline phosphatase, urinary calcium, parathyroid hormone and lower levels of serum phosphorus and urinary calculi history, X-ray showed decreased bone density, extensive fibrosis, cystic degeneration. Histopathological examination showed a lesion with newly formed bone tissue, diffuse giant cells and deposits of haemosiderin in a background of fibrovascular proliferation. Conclusion: The diagnosis of mandibular brown tumour was suggested by the clinical history and confirmed by laboratory investigations including calcium, phosphorus, alkaline phosphatase, parathormone assays, computed tomography and histopathological determinations. For mandibular cystic lesions associated with urinary tract stones, hypercalcaemia, osteoporosis, brown tumours should be highly suspected. A majority of these lesions may disappear with the removal of the parathyroid pathology.
Y.Y. Zhang ∗ , D.C. Wang, J.Z. Su, L.F. Jia, X. Peng, G.Y. Yu http://dx.doi.org/10.1016/j.ijom.2017.02.1003 Peking University School and Hospital of Stomatology, China Background: The clinicopathological features and outcomes of squamous cell carcinoma (SCC) of the tongue in patients of different age groups remain debatable. Objectives: To evaluate biological behaviours and outcomes of tongue SCC in different age groups. Methods: Medical records of 457 patients with tongue SCC were reviewed, grouped by age, and followed up. The clinicopathological features of the tumours and patients’ outcomes in different age groups were compared. Findings and conclusion: Gender, TNM stage, disease-free survival (DFS), and disease-specific survival (DSS) showed no inter-group differences. Patients aged 46–59 years had the most severe smoking and drinking habits (42.9% and 35.3%, respectively). Tongue SCC in patients’ ≤30 years had the most advanced TNM stage and the greatest proportion of poorly differentiated tumours. The death rate caused by recurrence or metastasis in the youngest group was much higher than the other two groups (91.7% versus 75.4% and 77.4%, respectively). Young patients had higher incidence of distant metastasis and recurrence death rate than middle-aged and oldest patients. http://dx.doi.org/10.1016/j.ijom.2017.02.1002 Brown tumour of the mandible: report of two cases and review of the literature H.X. Zou ∗ , J. Jia, Y.F. Zhao Wuhan University, Wuhan, China Objectives: Brown tumours are non-neoplastic lesions resulting from abnormal bone metabolism in hyperparathyroidism. The mandible involvement is exceptional, we describe such two cases and highlight the importance of taking a comprehensive history and focusing the investigations so that appropriate treatment can be given. Methods: A retrospective analysis of two cases of mandibular brown tumour patients in our hospital, one case occurred in the anterior portion of the mandible, another case occurred in the
Oral and Maxillofacial Pathology Enucleation with adjuvant therapy as treatment modality for ameloblastoma — a retrospective analysis of 10 years A. Akare ∗ , A. Datarkar, P. Pandilwar Government Dental College and Hospital, Nagpur, India Background: Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. Historically, the extent of resection has been controversial, comprising of two surgical options: ‘conservative’ versus ‘radical’. Objective: The aim of this presentation is to retrospectively evaluate the patients with ameloblastoma treated in our department with enucleation and adjuvant therapy followed for 10 years. Methods: A retrospective study was done in the Department of Oral and Maxillofacial Surgery, Government Dental College and Hospital, Nagpur. The demographic data was collected retrospectively from 89 patients, and clinical and radiographic features were carefully documented. Type of ameloblastoma, size and site of lesion, sufficient amount of remaining healthy bone, and the type of treatment, received conservative as enucleation, along with or without adjuvant therapy or radical resection were studied. Result: Total of 89 patients presented to the department with pathology, of whom 39 patients (mean age, 30 years) were diagnosed as Ameloblastoma and included in the study. Radiographically shows unilocular and multilocular radiolucency, histologically reported unicystic/mural ameloblastoma or plexiform ameloblastoma were treated by enucleation along with adjuvant therapy and under follow-up for past 10 years. Conclusion: Therapeutically, simple enucleation has no role in the management of ameloblastoma but the study concluded that enucleation along with the adjuvant therapy has played important role in treating ameloblastoma perhaps the unicystic subtype. Advantages of enucleation include the fact that it requires no reconstruction. http://dx.doi.org/10.1016/j.ijom.2017.02.1004
maxilla and mandible involved femur, ribs and skull. The clinical features, laboratory investigations, pathological characteristics, imaging findings and treatment were retrospectively analysed. Findings: Both patients showed weight loss, fatigue, anorexia, nausea, pain and decreased bone density, high levels of serum calcium, alkaline phosphatase, urinary calcium, parathyroid hormone and lower levels of serum phosphorus and urinary calculi history, X-ray showed decreased bone density, extensive fibrosis, cystic degeneration. Histopathological examination showed a lesion with newly formed bone tissue, diffuse giant cells and deposits of haemosiderin in a background of fibrovascular proliferation. Conclusion: The diagnosis of mandibular brown tumour was suggested by the clinical history and confirmed by laboratory investigations including calcium, phosphorus, alkaline phosphatase, parathormone assays, computed tomography and histopathological determinations. For mandibular cystic lesions associated with urinary tract stones, hypercalcaemia, osteoporosis, brown tumours should be highly suspected. A majority of these lesions may disappear with the removal of the parathyroid pathology.
Y.Y. Zhang ∗ , D.C. Wang, J.Z. Su, L.F. Jia, X. Peng, G.Y. Yu http://dx.doi.org/10.1016/j.ijom.2017.02.1003 Peking University School and Hospital of Stomatology, China Background: The clinicopathological features and outcomes of squamous cell carcinoma (SCC) of the tongue in patients of different age groups remain debatable. Objectives: To evaluate biological behaviours and outcomes of tongue SCC in different age groups. Methods: Medical records of 457 patients with tongue SCC were reviewed, grouped by age, and followed up. The clinicopathological features of the tumours and patients’ outcomes in different age groups were compared. Findings and conclusion: Gender, TNM stage, disease-free survival (DFS), and disease-specific survival (DSS) showed no inter-group differences. Patients aged 46–59 years had the most severe smoking and drinking habits (42.9% and 35.3%, respectively). Tongue SCC in patients’ ≤30 years had the most advanced TNM stage and the greatest proportion of poorly differentiated tumours. The death rate caused by recurrence or metastasis in the youngest group was much higher than the other two groups (91.7% versus 75.4% and 77.4%, respectively). Young patients had higher incidence of distant metastasis and recurrence death rate than middle-aged and oldest patients. http://dx.doi.org/10.1016/j.ijom.2017.02.1002 Brown tumour of the mandible: report of two cases and review of the literature H.X. Zou ∗ , J. Jia, Y.F. Zhao Wuhan University, Wuhan, China Objectives: Brown tumours are non-neoplastic lesions resulting from abnormal bone metabolism in hyperparathyroidism. The mandible involvement is exceptional, we describe such two cases and highlight the importance of taking a comprehensive history and focusing the investigations so that appropriate treatment can be given. Methods: A retrospective analysis of two cases of mandibular brown tumour patients in our hospital, one case occurred in the anterior portion of the mandible, another case occurred in the
Oral and Maxillofacial Pathology Enucleation with adjuvant therapy as treatment modality for ameloblastoma — a retrospective analysis of 10 years A. Akare ∗ , A. Datarkar, P. Pandilwar Government Dental College and Hospital, Nagpur, India Background: Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. Historically, the extent of resection has been controversial, comprising of two surgical options: ‘conservative’ versus ‘radical’. Objective: The aim of this presentation is to retrospectively evaluate the patients with ameloblastoma treated in our department with enucleation and adjuvant therapy followed for 10 years. Methods: A retrospective study was done in the Department of Oral and Maxillofacial Surgery, Government Dental College and Hospital, Nagpur. The demographic data was collected retrospectively from 89 patients, and clinical and radiographic features were carefully documented. Type of ameloblastoma, size and site of lesion, sufficient amount of remaining healthy bone, and the type of treatment, received conservative as enucleation, along with or without adjuvant therapy or radical resection were studied. Result: Total of 89 patients presented to the department with pathology, of whom 39 patients (mean age, 30 years) were diagnosed as Ameloblastoma and included in the study. Radiographically shows unilocular and multilocular radiolucency, histologically reported unicystic/mural ameloblastoma or plexiform ameloblastoma were treated by enucleation along with adjuvant therapy and under follow-up for past 10 years. Conclusion: Therapeutically, simple enucleation has no role in the management of ameloblastoma but the study concluded that enucleation along with the adjuvant therapy has played important role in treating ameloblastoma perhaps the unicystic subtype. Advantages of enucleation include the fact that it requires no reconstruction. http://dx.doi.org/10.1016/j.ijom.2017.02.1004