- Email: [email protected]
Comparison of improvements in facial skin appearance among women in 2 different age groups after cosmetic moisturizer treatments
P8184
P7964
Comparison of improvements in facial skin appearance among women in 2 different age groups after cosmetic moisturizer treatments Uma Santhanam, PhD, Global R&D, Avon Products, Inc, Suffern, NY, United States; Dawn Paradie, Global R&D, Avon Products, Inc, Suffern, NY, United States; John Lyga, PhD, Global R&D, Avon Products, Inc, Suffern, NY, United States
Evaluation of the efficacy of a facial lotion in females with stressful lifestyles Maria Vitale, L’Oreal Research & Innovation, Clark, NJ, United States; Christian Oresajo, L’Oreal Research & Innovation, Clark, NJ, United States; Margarita Yatskayer, L’Oreal Research & Innovation, Clark, NJ, United States; Valerie Robert, L’Oreal Research & Innovation, Clark, NJ, United States
Background: With the aging of the baby boomer generation, the desire for cosmetic products to improve the appearance of facial skin continues to expand into older populations of women. As a result, there is a need to understand how cosmetic products impact the appearance of facial skin in different groups of aged populations. The goal of this study was to clinically evaluate the ability of 2 different cosmetic skin treatment products to elicit an improvement in skin attributes associated with photodamaged skin n white women of 2 different age groups: 30-59 and 60-75.
Introduction: Stressful situations have been shown to induce many physiologic responses, including variations in facial skin conductance, redness, and skin temperature. There is a need for a topical product that reduces the visible signs of stress, which include redness, skin fatigue, and dryness. The purpose of the study was to evaluate a facial lotion containing Rosa Gallica Extract, Chamomilla extract and Mannose in females who live stressful lifestyles. Method: This clinical study included 50 female subjects aged 18 and 45 who professed and agreed that their stressful lifestyles have resulted in mild to moderate dryness, dullness, skin fatigues, and redness. Evaluations were done at baseline, postapplication, and challenge with interview, and after 1 day, 1 week, and 4 weeks of product application. Assessment of skin redness and transepidermal water loss (TEWL) were done on both sides of the face before product application and after interview challenge. Product was applied to a randomized side of the face, the other side left untreated serving as a control. In order to trigger a stressful situation subjects were subjected to an interview which lasted 5 minutes. Subjects began fullface application of the facial lotion, twice daily, on day 1. Evaluations were performed by an expert grader for long-term efficacy and included grading of objective and subjective tolerance and clinical efficacy. TEWL, subject selfassessment questionnaires, and digital photography were also included in the study. Result: The results showed that immediately after the stressful interview an increase in skin redness was observed on both the treated and untreated side of the face. However, there was no significant difference between the 2 sides of the face. There was a significant improvement in skin dryness, softness, smoothness, radiance, blotchiness, fatigue, overall facial lines, and skin quality after 1 week and confirmed after 4 weeks. There was an improvement in skin redness after 4 weeks of product use. There were no significant differences in TEWL values after 4 weeks of product use when compared to baseline indicating the product is mild and does not cause skin barrier damage. The product was well tolerated by the subjects after 4 weeks of use.
Methods: Two independent randomized, double-blind 12-week facial studies were conducted in the US enrolling women from 2 different age groups, 30-59 and 60-75, with mild to moderate signs of skin aging (including fine and coarse wrinkling, and discrete andmottled pigmentation and overall photodamage). The women in each age group applied 2 different moisturizer formulations once daily: moisturizer formulation 1 containing a mixture of active synthetics and botanical extracts or formulation 2, with the above combination of actives plus glycolic acid and thiodipropionic acid, an antioxidant. Grading of subjects for visual improvement in various attributes on a 0-9 scale was performed by a board-certified dermatologist at week 1, 2, 4, 8, and 12. Responses were compared among the 2 age groups. Results: Women in both the younger and the older age groups demonstrated significant improvement from baseline in pigmentation, wrinkles and overall photodamage in response to application of moisturizer formulations for 12 weeks. With the use of formulation 1, it was observed that the magnitude of improvement in most of the individual attributes in the younger group was significantly higher relative to the older group. With formula 2, the wrinkling and photodamage improvements were significantly higher in the younger group but similar improvements in pigmentation was seen in both the older and younger groups. The lower magnitude of response for certain attributes in older women may be related to the fact that the respective baseline scores were higher, as expected in the older population. The above studies suggest that, in general, improvements in age-related appearance of skin following treatment with cosmetic moisturizers can be elicited regardless of age.
Sponsored 100% by L’Oreal.
Commercial support: None identified.
P8138 Efficacy comparison of a cosmetic exfoliation system with professional microdermabrasion Joseph Kaczvinsky, PhD, The Procter and Gamble Company, Cincinnati, OH, United States; Catherine Mack, The Procter and Gamble Company, Cincinnati, OH, United States; James Li, MS, The Procter and Gamble Company, Cincinnati, OH, United States; Kali Ghazali, Vitiligo and Pigmentation Institute of Southern California, Los Angeles, CA, United States; Michael Marmor, The Procter and Gamble Company, Cincinnati, OH, United States; Pearl Grimes, MD, The Vitiligo and Pigmentation Institute of Southern California, Los Angeles, CA, United States Objective: The primary objective of this study was to compare the effectiveness of a cosmetic microdermabrasion (MDA) system versus a leading professional MDA treatment for exfoliation. Secondary objectives compared the 2 systems’ effects on skin barrier, hydration, and visual assessments of skin attributes.
P8366
Results: The cosmetic MDA system produced significantly higher exfoliation than NT at day 7 pre- and posttreatment (P \.001). Furthermore, equivalent exfoliation was seen from each MDA treatment at both day 7 pretreatment and day 7 posttreatment. After 7 and 14 days, the physician’s evaluations showed that there a noticeable improvement in the subjects’ skin texture and pores for both treatments and no significant difference in response between the MDA treatments. Seventy percent of subjects noticed improvements with both MDA systems. The cosmetic MDA system significantly prevented the loss of skin hydration compared to the professionally administered MDA treatment 7 days posttreatment. Barrier was not disrupted by either treatment and both were well tolerated throughout the course of the study. Conclusion: Used as intended, the cosmetic MDA system exfoliated as effectively as a professional MDA treatment and produced comparable or better improvements in hydration and in the appearance of skin texture and pores.
Immunohistologic analysis of biopsy specimens from a double-blind, vehicle controlled, 1-year clinical study on 0.1% stabilized retinol as an antiaging technology Samantha Tucker Samaras, PhD, Johnson & Johnson Consumer Companies, Inc, Skillman, NJ, United States; Jared Fantasia, MS, Johnson & Johnson Consumer Companies, Inc, Skillman, NJ, United States; Jipsha Thakrar, Johnson & Johnson Consumer Companies, Inc, Skillman, NJ, United States; Manpreet Randhawa, ScD, Johnson & Johnson Consumer Companies, Inc, Skillman, NJ, United States Many new antiaging technologies have demonstrated clinical benefits appropriate for aging patients who visit a dermatology practice seeking visible improvements. Many are expecting immediate results, but scientists and practicing clinicians recognize that greater improvement can be attained over longer time periods. Many traditional antiaging clinical studies have included 1-, 2-, and 3-month time points. However, additional benefits can expect to be seen with longer usage. This clinical investigation comprises a histologic assessment of biopsy specimens taken from a double-blind, vehicle-controlled, 1-year clinical study on 0.1% stabilized retinol formulation. All patients were females between 40 and 55 years with moderately photodamaged facial skin representing Fitzpatrick skin types I-III. The antiaging technology was assessed versus its vehicle throughout the 1 year of daily facial product usage with biopsy specimens taken at baseline, 6 months, and 52 weeks of the study. Immunohistochemical assessments were performed to investigate the effects on epidermal proliferation and extracellular matrix production. KI-67, a cellular marker of proliferation was increased in the retinol-treated biopsy specimens for both the 6- and 12-month groups compared to vehicle, and the 12month group had increased number of subjects stained positive for Ki-67 compared to the 6-month group, indicating that continued use of the retinol formulation resulted in a greater effect. ECM protein expression measured by collagen staining and hyaluronic acid and were both increased in the retinol treated biopsies at the 6and 12-month timepoints compared to vehicle. Taken together, these histologic findings demonstrate that use of a 0.1% stabilized retinol formulation resulted in continued and increased efficacy over the 52-week study The publication of robust clinical studies with antiaging cosmeceutical formulations that are tested over longer time periods provide excellent evidence-based results that enable practicing dermatologists to confidently recommend the most appropriate products for their patients.
Study was 100% sponsored and funded by the Procter & Gamble Company.
Sponsored 100% by Johnson & Johnson Consumer Companies, Inc.
Methods: A randomized, double-blind, no treatment-controlled, 2-wk, split-face facial study was conducted including 41 female subjects aged 35-65 with Fitzpatrick skin types I-V. Following a 3-day preconditioning period, 2 small areas on each side of the face were stained with the self-tanning ingredient dihydroxyacetone (DHA). One of the stained areas on each side of the face was a no treatment (NT) site. Subjects treated one side of their face (except the NT site) 2 times weekly with a cosmetic exfoliation system consisting of a battery-operated implement with a rotating foam head with added abrasive sodium bicarbonate crystals. The other side of the face (except the NT site) underwent a professional MDA treatment administered in a dermatologist’s office on day 1 and day 7. The primary exfoliation measure was color loss in the DHA stained areas of the face at day 7 pretreatment as measured by chromameter. Hydration and TEWL measurements were also taken and facial images were taken for physician’s assessments of visual changes. Subject self-evaluations were taken via questionnaire.
AB24
J AM ACAD DERMATOL
MAY 2014
P7964
Comparison of improvements in facial skin appearance among women in 2 different age groups after cosmetic moisturizer treatments Uma Santhanam, PhD, Global R&D, Avon Products, Inc, Suffern, NY, United States; Dawn Paradie, Global R&D, Avon Products, Inc, Suffern, NY, United States; John Lyga, PhD, Global R&D, Avon Products, Inc, Suffern, NY, United States
Evaluation of the efficacy of a facial lotion in females with stressful lifestyles Maria Vitale, L’Oreal Research & Innovation, Clark, NJ, United States; Christian Oresajo, L’Oreal Research & Innovation, Clark, NJ, United States; Margarita Yatskayer, L’Oreal Research & Innovation, Clark, NJ, United States; Valerie Robert, L’Oreal Research & Innovation, Clark, NJ, United States
Background: With the aging of the baby boomer generation, the desire for cosmetic products to improve the appearance of facial skin continues to expand into older populations of women. As a result, there is a need to understand how cosmetic products impact the appearance of facial skin in different groups of aged populations. The goal of this study was to clinically evaluate the ability of 2 different cosmetic skin treatment products to elicit an improvement in skin attributes associated with photodamaged skin n white women of 2 different age groups: 30-59 and 60-75.
Introduction: Stressful situations have been shown to induce many physiologic responses, including variations in facial skin conductance, redness, and skin temperature. There is a need for a topical product that reduces the visible signs of stress, which include redness, skin fatigue, and dryness. The purpose of the study was to evaluate a facial lotion containing Rosa Gallica Extract, Chamomilla extract and Mannose in females who live stressful lifestyles. Method: This clinical study included 50 female subjects aged 18 and 45 who professed and agreed that their stressful lifestyles have resulted in mild to moderate dryness, dullness, skin fatigues, and redness. Evaluations were done at baseline, postapplication, and challenge with interview, and after 1 day, 1 week, and 4 weeks of product application. Assessment of skin redness and transepidermal water loss (TEWL) were done on both sides of the face before product application and after interview challenge. Product was applied to a randomized side of the face, the other side left untreated serving as a control. In order to trigger a stressful situation subjects were subjected to an interview which lasted 5 minutes. Subjects began fullface application of the facial lotion, twice daily, on day 1. Evaluations were performed by an expert grader for long-term efficacy and included grading of objective and subjective tolerance and clinical efficacy. TEWL, subject selfassessment questionnaires, and digital photography were also included in the study. Result: The results showed that immediately after the stressful interview an increase in skin redness was observed on both the treated and untreated side of the face. However, there was no significant difference between the 2 sides of the face. There was a significant improvement in skin dryness, softness, smoothness, radiance, blotchiness, fatigue, overall facial lines, and skin quality after 1 week and confirmed after 4 weeks. There was an improvement in skin redness after 4 weeks of product use. There were no significant differences in TEWL values after 4 weeks of product use when compared to baseline indicating the product is mild and does not cause skin barrier damage. The product was well tolerated by the subjects after 4 weeks of use.
Methods: Two independent randomized, double-blind 12-week facial studies were conducted in the US enrolling women from 2 different age groups, 30-59 and 60-75, with mild to moderate signs of skin aging (including fine and coarse wrinkling, and discrete andmottled pigmentation and overall photodamage). The women in each age group applied 2 different moisturizer formulations once daily: moisturizer formulation 1 containing a mixture of active synthetics and botanical extracts or formulation 2, with the above combination of actives plus glycolic acid and thiodipropionic acid, an antioxidant. Grading of subjects for visual improvement in various attributes on a 0-9 scale was performed by a board-certified dermatologist at week 1, 2, 4, 8, and 12. Responses were compared among the 2 age groups. Results: Women in both the younger and the older age groups demonstrated significant improvement from baseline in pigmentation, wrinkles and overall photodamage in response to application of moisturizer formulations for 12 weeks. With the use of formulation 1, it was observed that the magnitude of improvement in most of the individual attributes in the younger group was significantly higher relative to the older group. With formula 2, the wrinkling and photodamage improvements were significantly higher in the younger group but similar improvements in pigmentation was seen in both the older and younger groups. The lower magnitude of response for certain attributes in older women may be related to the fact that the respective baseline scores were higher, as expected in the older population. The above studies suggest that, in general, improvements in age-related appearance of skin following treatment with cosmetic moisturizers can be elicited regardless of age.
Sponsored 100% by L’Oreal.
Commercial support: None identified.
P8138 Efficacy comparison of a cosmetic exfoliation system with professional microdermabrasion Joseph Kaczvinsky, PhD, The Procter and Gamble Company, Cincinnati, OH, United States; Catherine Mack, The Procter and Gamble Company, Cincinnati, OH, United States; James Li, MS, The Procter and Gamble Company, Cincinnati, OH, United States; Kali Ghazali, Vitiligo and Pigmentation Institute of Southern California, Los Angeles, CA, United States; Michael Marmor, The Procter and Gamble Company, Cincinnati, OH, United States; Pearl Grimes, MD, The Vitiligo and Pigmentation Institute of Southern California, Los Angeles, CA, United States Objective: The primary objective of this study was to compare the effectiveness of a cosmetic microdermabrasion (MDA) system versus a leading professional MDA treatment for exfoliation. Secondary objectives compared the 2 systems’ effects on skin barrier, hydration, and visual assessments of skin attributes.
P8366
Results: The cosmetic MDA system produced significantly higher exfoliation than NT at day 7 pre- and posttreatment (P \.001). Furthermore, equivalent exfoliation was seen from each MDA treatment at both day 7 pretreatment and day 7 posttreatment. After 7 and 14 days, the physician’s evaluations showed that there a noticeable improvement in the subjects’ skin texture and pores for both treatments and no significant difference in response between the MDA treatments. Seventy percent of subjects noticed improvements with both MDA systems. The cosmetic MDA system significantly prevented the loss of skin hydration compared to the professionally administered MDA treatment 7 days posttreatment. Barrier was not disrupted by either treatment and both were well tolerated throughout the course of the study. Conclusion: Used as intended, the cosmetic MDA system exfoliated as effectively as a professional MDA treatment and produced comparable or better improvements in hydration and in the appearance of skin texture and pores.
Immunohistologic analysis of biopsy specimens from a double-blind, vehicle controlled, 1-year clinical study on 0.1% stabilized retinol as an antiaging technology Samantha Tucker Samaras, PhD, Johnson & Johnson Consumer Companies, Inc, Skillman, NJ, United States; Jared Fantasia, MS, Johnson & Johnson Consumer Companies, Inc, Skillman, NJ, United States; Jipsha Thakrar, Johnson & Johnson Consumer Companies, Inc, Skillman, NJ, United States; Manpreet Randhawa, ScD, Johnson & Johnson Consumer Companies, Inc, Skillman, NJ, United States Many new antiaging technologies have demonstrated clinical benefits appropriate for aging patients who visit a dermatology practice seeking visible improvements. Many are expecting immediate results, but scientists and practicing clinicians recognize that greater improvement can be attained over longer time periods. Many traditional antiaging clinical studies have included 1-, 2-, and 3-month time points. However, additional benefits can expect to be seen with longer usage. This clinical investigation comprises a histologic assessment of biopsy specimens taken from a double-blind, vehicle-controlled, 1-year clinical study on 0.1% stabilized retinol formulation. All patients were females between 40 and 55 years with moderately photodamaged facial skin representing Fitzpatrick skin types I-III. The antiaging technology was assessed versus its vehicle throughout the 1 year of daily facial product usage with biopsy specimens taken at baseline, 6 months, and 52 weeks of the study. Immunohistochemical assessments were performed to investigate the effects on epidermal proliferation and extracellular matrix production. KI-67, a cellular marker of proliferation was increased in the retinol-treated biopsy specimens for both the 6- and 12-month groups compared to vehicle, and the 12month group had increased number of subjects stained positive for Ki-67 compared to the 6-month group, indicating that continued use of the retinol formulation resulted in a greater effect. ECM protein expression measured by collagen staining and hyaluronic acid and were both increased in the retinol treated biopsies at the 6and 12-month timepoints compared to vehicle. Taken together, these histologic findings demonstrate that use of a 0.1% stabilized retinol formulation resulted in continued and increased efficacy over the 52-week study The publication of robust clinical studies with antiaging cosmeceutical formulations that are tested over longer time periods provide excellent evidence-based results that enable practicing dermatologists to confidently recommend the most appropriate products for their patients.
Study was 100% sponsored and funded by the Procter & Gamble Company.
Sponsored 100% by Johnson & Johnson Consumer Companies, Inc.
Methods: A randomized, double-blind, no treatment-controlled, 2-wk, split-face facial study was conducted including 41 female subjects aged 35-65 with Fitzpatrick skin types I-V. Following a 3-day preconditioning period, 2 small areas on each side of the face were stained with the self-tanning ingredient dihydroxyacetone (DHA). One of the stained areas on each side of the face was a no treatment (NT) site. Subjects treated one side of their face (except the NT site) 2 times weekly with a cosmetic exfoliation system consisting of a battery-operated implement with a rotating foam head with added abrasive sodium bicarbonate crystals. The other side of the face (except the NT site) underwent a professional MDA treatment administered in a dermatologist’s office on day 1 and day 7. The primary exfoliation measure was color loss in the DHA stained areas of the face at day 7 pretreatment as measured by chromameter. Hydration and TEWL measurements were also taken and facial images were taken for physician’s assessments of visual changes. Subject self-evaluations were taken via questionnaire.
AB24
J AM ACAD DERMATOL
MAY 2014