- Email: [email protected]
Compound Name and Code Number Index
COMPOUND NAME AND CODE NUMBER I N D E X
AA-861, 95 acetohydroxamic a c i d , 31 a c i v i c i n , 138 a c r i h e l l i n , 72 acy l o v i r , 122 C-c'Ado ( c a r b o c y c l i c 3-deazaadenos i n e , 120 adrenorphin, 2 a d r i a m y c i n , 142 AF64A ( e t h y l c h o l i n e mustard a z i r i dinium i o n ) , 32 a f l o q u a l o n e , 274, 313 AH 22216 ( L a m t i d i n e ) , 82 AH 23844 ( L o x t i d i n e ) , 82 a l b u t e r o l , 74 a l f e n t a n i l , 314 a l m i n o p r o f e n , 3 14 a l p i r o p r i d e (Riv 20931, 25 a l p r a z o l a m , 14 alprenolol, 7 a l r e s t a t i n (A4-22,284), 171, 172 a l t h i o m y c i n , 152 107 AMA-1080 (RO 17-2101), a m a n t a d i n e , 117, 118 a m d i n o c i l l i n ( m e c i l l i n a m ) , 109 b i s (5-amidino-2-benzimidazolyl) methane, 120 1 - a m i n o b e n z o t r i a z o l e , 20 3'-amino-2' , 3 ' - d i d e o x y c y t i d i n e , 138 2-amino-6,7-dihydroxybenzonorbornene, 51 6 - a m i n o l a e v u l i n i c a c i d , 55, 57 3-aminopropane s u l p h o n i c a c i d , 55 4-aminopyridine, 32 a m i s u l p r i d e (DAN 2163) , 25 amoxapine (CL 67,7721, 44 a m p h o t e r i c i n B , 127, 13.1-133 amrinone, 7 6 , 314 AMSA (4'-[ ( g - a c r i d i n y l ) a m i n o ] m e t h a n e - s u l p h o n - p a n i s i d i d e l , 143 androst-4-ene-3,17-dione, 208 a n i r a c e t a m (Ro 13-50571, 30 APB (2-amino-4-phosphonoheptanoic a c i d ) , 287 APP 201-533, 76 ARA-A, 123 ARA-C, 138 a r a c h i d o n i c a c i d , 214, 218 a r e c o l i n e , 32 a r g i n i n e v a s o p r e s s i n , 304 a r i l d o n e (Win 38,0201, 122 AR-L 115, 77 arugomycin, ( s u l m a z o l e ) , 142 ASI-222, 71
-
ANNUAL REPORTS IN MEDICINAL CHEMISTRY- 19
327 -
ASL-7022, 51, 7 3 a s p a r t a m e , 267 a s t e r n i z o l e , 98, 314 a t r i a l n a t r i u r e t i c f a c t o r , 253 a t r i o p e p t i n I , 67 a t r i o p e p t i n 11, 67 a u r a n o f i n , 314 auromomycin, 141 avermectin B l a ' 147 avermectin B 147 a x i l l a r i n , ?it; AY-22,284 ( a l r e s t a t i n ) , 171, 172 AY-27,773 ( t o l r e s t a t ) , 173 p - a z i d o b e n z y l c a r a z o l o l , 286 a z l o c i l l i n , 109 A1 34U [2,6-diamino-9-(2-hydroxye t h o x y m e t h y l ) p u r i n e ] , 123 A25822B, 131 A 32799, 25 BABIM [bis(5-amidino-2-benzimida z o l y l ) m e t h a n e , 120 b a c a m p i c i l l i n , 109 b a c l o f e n , 5 , 287 Bay-b-5097 ( c l o t r i m a z o l e ) , 127, 129, 131, 133 Bay-h-4502 ( b i f o n a z o l e ) , 127, 134 Bay k 8644, 65, 7 6 , 289 Bay-1-9139, 127, 128 Bay-n-7133, 127, 128 Bay n 2920, 163. Bay n 4605, 162 Bay o 1248, 162 Bay o 8278, 95 Bay 8751 ( v a l c o n a z o l e ) , 134 BD40, 143 BDF 6143, 51 BE 2254 (HEAT), 285 b e f u n o l o l , 315 bendazac, 173 benoxaprofen, 247 b e n z o t r i p t , 88 b e n z y l c h o l i n e mustard, 286 N-benzyl-1-(methy1)cyclopropyl amine, 205 4-(o-benzylphenoxy)-N-methylbutylamine H C 1 (MCI-20161, 32 b e p r i d i l , 98 b e t a x o l o l , 315 BHT, 274 B-HT 920, 51, 5 3 B-HT 933, 51 b i c u c u l l i n e , 287 b i f o n a z o l e (Bah-h-45021, 127 , 134, 315 b i s a n t r e n e , 143
Copyright 0 1984 by Academic Press, Inc. All rights of reproduction in any form reserved. ISBN 0-12-0405 19-9
328 BL 5255,
COMPOUND NAME AND CODE NUMBER INDEX
97 bleomycin, 139, 140 BM-5, 57 BMY-25260 (L-643,44 1 ) , 82 BMY-25368, 82 BMY-28 14 1, 109 bombesin, 160 bone r e s o r p t i o n f a c t o r , 236 bremazocine, 160, 288 BRL 20330, 109 BRL-20596, 24 BRL 20627, 24 BRL 22321, 97 BRL 268308, 165 bromocryptine, 57 2-bromolisuride, 27 brotizolam, 315 budesonide, 100, 273 budralazine, 63, 315 a-bungarotoxin (BTX) , 287 buprenorphine, 6 bupropion, 158 buquineran ( U K 14,275 1 75 burimamide, 55 buspirone, 15 butaclamol, 21 butoconazole, 133 bu topamine, 73 b u t y l flufenamate, 3 6 BVDU, 123 BW 245C, 62 BW 357U, 159 BW 683C. ( 4 ' ,6-dichloroflavan), 121 BW-755C, 246 BW 825C, 98 C-19393H2 (carpetimycin A ) , 110 cadexomer i o d i n e , 316 c a r d r a l a z i n e ( I S 24691, 63 carpetimycin C , 110 carpetimycin D , 110 c a l c i t r o i c a c i d , 180 calmodulin, 215 c a p t o p r i l , 278 c a r a z o l o l , 285 carbamazepine, 16 carbamylcholfne, 216 carbazeran, 75 carbocy l i c 3-deazaadenosine (C-c 9Ado), 120 carpetimycin A (C-19393H2), 110 c a r z i n o p h i l i n , 141 CCK, 34 CCK-4, 160 CCK-8, 160, 161 cehenoxime, 3 16 cefotaxime, 107 cefoperazone, 109 c e f o t e t a n , 109 ceftazidime, 109, 316
cefuroxime a x e t i l , 108 c e l i p r o l o l , 317 c e r u l e t i d e , 160 CG 4203, 62 CG 10213-90, 154 CGA 64151 (etaconazole), 131 CGA-89317 ( t r i c l a b e n d a z o l e ) , 151 CGP 11109, 25 CGP 12177, 286 CGP 28392, 289 CGS 8216, 13, 15 CGS 9896, 15, 288 CGS 10746 B , 22 CGS 13,945, 62 CGS 14,825A, 62 CGS 14,831 62 chenodiol, 317 chlorambucil, 138 ( - ) - t h r e o - c h l o r o c i t r i c acid, 161 c h o l a c a l c i o i c acid, 181 CI-844 (3-phenoxypyridine) , 36 CI-879 (pramiracetam), 36 CI-914, 75 c i c l a z i n d o l , 164 ciclopiroxolamine (HOE-2961, 134 c i l a s t a t i n (MK0791 1, 110 4-(Cinnamylthio)l-@-D-ribofuranoxyl1H-pyrazole [3,4-d]pyrirnidine, 152 c i m e t i d i n e , 81, 82 ciramadol, 6 cisapride (R 516191, 24 citalopram, 54 CL 115,347, 62 CL 115,574, 86 CL 218,872, 12, 13, 15, 288 c l e n b u t e r o l (NAB 3651, 43 clobazam, 14 c l o f i b r a t e , 208 c l o r a z e p a t e , 14 clomipramine ( G 345861, 42, 44, 46 clonazepam, 288 c l o n i d i n e , 5, 56 c l o p e n t h i x o l deconoate, 21 c l o t r i m a z o l e (Bay-b-50971, 127, 129, 131, 133 clovoxamine, 278 clozapine, 21, 44 CM 40874, 108 CM 57373, 158 CM 57493, 158 CN-146, 130 a-CNA, 3 B-CNA, 3 c7-OBQ, 53 compactin, 267, 269 coumermycin, 143 CP 45,634 ( s o r b i n i l ) , 170-172 cromolyn sodium (FPL 6701, 96, 97 cyanopindolol, 285
COMPOUND NAME AND CODE NUMBER INDEX
329
c y c l a r a d i n e , 123 2-(2,3-dimethylphenoxy)-methylc y c l i z i n e , 55 i m i d a z o l i n e , 1.49 c y c l o - ( a r g - g l y ) , 35 2-(2,3-dimethylphenyl)-2,3,5,6-tetrac y c l o s p o r i n e , 317 hydroimidazo[2,1-b]thiazole, 149 D-600, 64, 289 d i m e t r a c i n , 44 DA 4577, 83 d i p r e n o r p h i n e , 35, 161 DADLE , 6 , '288 N,N-dipropyl-2-amino-7-hydroxyDACO, 288 t e t r a l i n , 53 d a u n o r u b i c i n , 143 dobutamine., 73 . d a z o x i b e n , 101 domperidone, 34, 284 (DBE) d i h y d r o - b e t a - e r y t h r o i d i n e , 287 doxaminol, 74 DC-52, 140 DP-6,7-ADTN, 51 cis-DDP(*-diaminedichloroplatinum dynorphin, 2 111, 137, 139 dynorphin ( 1-8 1, 267 trans-DDP, 139 e c o n a z o l e (R148271, 131-133 DDAVP ( d e s m o p r e s s i n ) , 34 e l l i p t i c i n e , 143 10-deazaaminopterin, 137 e n a l a p r i l (MK-4211, 62 d e c i l o r u b i c i n , 142 @-endorphin, 2 , 4 d e l t a s l e e p - i n d u c i n g p e p t i d e , 16 e n k e p h a l i n , 1-3 , 6 denzimol, 17 e n o c i t a b i n e , 318 deoxynor j i r i m y c i n , 162, 163 e n p r o f y l l i n e , 100 dermorphin, 2 , 3 enviroxime (LY 122772 1, 120 3~-desamin0-3~-morpholinodaunorabicine p e r i s o n e , 318 (3'-MD), 142 4'epidoxorubicin, 137, 142 8-epi-thienamycin, 110 d e s m o p r e s s i n (DDABP), 34 dezocine, 6 e p o p r o s t e n o l , 3 18 DFMO._ _(DL-a-difluromethyl-ornithine) , e t a c o n a z o l e (CGA 64251), 131 153 e t a z o l a t e , 15, 288 DCAVP, 34 4'-ethoxy-2'hydroxy-4 , 6 -dimet h XYDHAQ, 143 c h a l c o n e (Ro 09-0410 , 121 2,5-diamino-9-2-(hydroxyethoxymethYl) e t o m i d a t e , 12, 16 p u r i n e (A134U1, 123 etonitazene, 3 3 , 4 - d i a m i n o p y r i d i n e , 32 e t h y l c h o l i n e mustard a z r i d i n i u m c i s -diamined i c h l o r o p l a t i n u m 11 i o n (AF64A), 32 , 137 ethylketocyclazocine, (*-DDP) 60 d i b e n y l i n e , 286 e t i n t i d i n e , 82 cis-dichloro-trans-dihydroxy-&etiracetam, 36 i s o p r o p y l a m i n e p l a t i n u m V I ( C H I P ) farnotidine, 82 139 FCE 20485, 108 4 1 6 - d i c h l o r o f l a v a n (BW683C), 121 FCE 22553, 109 2- ( 3 , 4 -d i c h l o r o phenoxy - 5 - n i t r o FCE 22891, 109 b e n z o n i t r i l e (MDL-860), 121 femoxetine, 45, 157 diclofenac, 7 f e n b u p r o l , 318 5,8-dideazaisopteroyltlutamate fendosal, 7 (IAHQ), 137 f e n f l u r a m i n e , 44, 157, 161, 162 diflunisal, 6, 7 f e n o c t i m i n e , 85 D L - a - d i f l u o r o m e t h y l o r n i t h i n e (DFMO), f e n o t e r o l , 74 153 f e n t a n y l , 273 d i ' h y d r o a l p r e n o l o l , 285 f i b r o n e c t i n , 236 147 FG 7142, 12 22,23-dihydroavermectin B l a , d i h y d r o e r g o t a m i n e , 7 , 42, 45, 56 FIAC, 123 4' ,5-dihydroxy-3,3' ,7-trimethoxyFK 027 (FR 17027), 108 f l a v o n e (Ro 09-0179), 121 FK 33-824, 88 FKK, 100 la,25-dihydroxyvitamin D [ ( 1 , 2 5 FLA 965 (OH) D 11, 179 18 1 FLB 13 1 , 25 24, R-25Zd?hydroxyvitamine D~ , d i l t i a z e m , 63, 64, 98, 289 f l o r d i p i n e , 64 d i m a p r i t , 55 f l u m e t h r i n , 151 f l u n a ri zi n e , 7
-
330
COMPOUND NAME AND CODE NUMBER INDEX
f lu n itr azep a m , 11, 14 c i s - f l u p e n t h i x o l (N-70091, 47 f l u p e r l a p i n e (NB 106-6891, 22 f lu p h en a zin e, 47 5 - f lu o r o c y to si ne (Ro 2-9915) ( f l u c y t o s i n e ) , 127, 133 f l u o x e t i n e , 42, 43, 4 4 , 45, 46 f lu r b ip r o p h e n, 7 f lu ta mid e, 318 fluvoxamine, 42, 3 19 FMAU, 123 FMLP (N-formylmethionyl-leucylp h en y la la ni ne) , 236 B-FNA, 3 B-FOA, 3 N-formimidoyl thienamycin, (imipenem, MK0787), 110 N-formylmethionyl-leucyl-phenyla l a n i n e (FMLP), 236 f o r s k o l i n , 76, 101, 293 FPL 670 (cromolyn sodium), 96, 97 FPL 52694, 85 FPL 55712, 93, 94, 96, 242, 244, 246-8 FPL 58668 ( p r o b i c r o m i l ) , 97 FPL 59257, 96 FR 17027 (FK 0271, 108 FR 34235, 65 FR 900318, 110 g a l l i a m n i t r a t e , 139 g allo p amil, 319 gemeprost, 319 g i l v o c a r c i n V , 141 g i t o f o r m a t e , 71 glucagon, 34 GP 50302, 22 guanadre 1, 3 19 g u an f a cin e, 277 G Y K l 13 380, 160 H-77, 61 H 149/94 ( p i c o p r a z o l e ) , 84 H 168/68 (omeprazole), 84 halofuginone, 154 halometasone, 320 halazepam, 14 HBB 2-(or-hydroxybenzyl)benzimidaz o l e , 120 HEAT (BE 22541, 285 HOE-040, 72 HOE-296 ( c ic l opi r oxol am i ne) , 134 HOE 892, 87 HR 375, 24 HR 810, 109 HRP 913, 23 hydrocortisone b u t y r a t e pr opi onat e, 320 4-hydroperoxy i f os f am i de, 138
4-hydroxyandrost-4-ene-3,17-dione, 27 3
2-(or-hydroxybenzyl)benzimidzole (HBB), 120 hydroxybenzylisoproterenol, 286 9- [2-hydroxy-l- (hydroxymethyl) ethoxymethyllguanine, 123 7-hydroxy-methotrexate (7-OH M T X ) , 137 B-hydroxy-B-methylglutaric a c i d , 321 erythro-9-(2-hydroxy-3-nonyl)adeni ne, 16 25-hydroxy-10-oxo-19-norvitamin D 3' 183 ibopamine, 73 ibuprophen, 6 ICI-105,552, 172, 173 ICI-1 18.587 (xamoterol), 74 ICI-128 ;436, 173 ICI-14'1,292, 67 ICI-153,066, 128, 131 idazoxan ( R X 7810941, 51 ifosfamide, 138 IL-2 ( i n t e r l e u k i n 2 ) , 191-198 imipenem (N-formimidoyl t hi enamycin, MK07871, 110 i n d a l p i n e , 320 i n t e r l e u k i n - 2 (IL-21, 191-198, 236 indoprophen, 6 iodohydroxybenzylpindolol, 285 i prat ropi um , 98, 99 i p r i n d o l e , 42, 43, 4 4 , 45, 47 IPS 339, 285 ISF 2469 ( c a d r a l a z i n e ) , 63 1 ~ ~ - 2 5 2 2(oxi racet am ), 36 i soconazol e, 131-133 2-isopropyl-4-pentenarnide (AIA), 201, 207 isoxicam, 320 i t r a c o n a z o l e (R512111, 128 i verm ect i n, 147 JPC-60-36, 158, 159 JPC-211, 158, 159 K-351, 67 KB-944, 65 KB-1585, 109 KC-404, 96 k e t a n s e r i n , 65, 286 ketoconazole, 127-1 34 k i j a n i m i c i n , 142 KF-4942, 66 KY-087, 108 KY-109, 108 L-640,876, 109 L-643,441 (BMY-25260), 82, 288 1,644,440, 109 L646,591, 109 labetalol, 6 laidlomycin, 152 l a m t i d i n e (AH222161, 82 LC-6, 95
-
COMPOUND NAME AND CODE NUMBER INDEX
308 l i s i n a p r i l (MK-521), 62 l i t o r i n , 160 lodoxamide tromethamine (U-42,585E), 97 loprazolam, 1 4 , 321 lorazepam, 14 loxapine, 44 l o x i t i d i n e (AH 238441, 82 l o z i l u r e a , 88 4R,5S,6Z-2-nor LTD1, 248 LUR 2366, 25 LY 53857, 65 LY 79771, 165 LY 81067, 17 LY 104119, 165 LY 122771 (enviroxime), 120 LY 141865, 21, 66 M-7, 51 M-83 [7-N-(p-hydroxyphenyl)mitomycin-Cl, 140 M 79175, 172 M12325 (Sodium 5-aminosulfonyl2,4-dichlorobenzoate), 122 macrocortin, 216 m a p r o t i l i n e (Ba-34,276), 42 m a r i n a c t i n , 142 mazindol, 164 MB11008, 159 M & B 22,948 ( z a p r i n a s t ) , 97 MCI-2016 (4-(o-benzy1phenoxy-Nmethylbutylamine H C L ) , 32, 84 McN-A-343, 286 MD 781124, 25 MDL 646, 86 MDL-860 (2-(3,4-dichlorophenoxy)5-nitrobenzonitrile), 121 MDL 899, 63 MDL-17,043, 77 MDL-19,205, 77 mebendazole, 149, 150 mecamylamine, 287 mecillinam ( a m i n o c i l l i n ) , 109 mefloquine, 153 meglutol, 321 a-melanotropin, 306 merpacrine, 317 m e p r o s c i l l a r i n , 72 meptazinol, 6, 288, 321 metergoline, 53 N-methyl-D-aspartate ( N M D A ) , 287 cis-methyldilvasene, 286 N-methyl-4-piperidinyl b e n z i l a t e , 286 m e t i t e p i n e , 53 metkephamid, 6 metorphamide, 2 m e z l o c i l l i n , 109 mianserin, 43, 4 4 , 45, 56, 84, 286 LHRH,
33 1 -
miconazole (R148891, 127-129, 131133 midazolam, 5 , 14 milbemycin, 148 milenperone (R 34009), 23 milrinone, 76 minoxidil o - s u l f a t e , 63 m i s o p r o s t i l (SC29333), 86 mitocymin c , 140 mitoxantrone, 137, 143 MJ 13805, 15 MJ 13859, 23 M J 13980-1, 26 MK 212, 290 MK-401, 151 MK-421 ( e n a l a p r i l ) , 62 MK-521 ( l i s i n a p r i l ) , 62 MK 801, 290 MK 0787 IN-formimidoyl thienamycin, (imipenem)], 110 MK 0791 ( c i l a s t a t i n ) , 110 MM 4550, 110 MM 13902, 109, 110 MM 17880, 110 monensin, 152 morantel, 150 morphiceptin, 2 moxalactam, 107 MPE Fe 11, 137 MPV295, 66 M r 1452, 161 Mr 2034, 2 M r 2266, 161 CI-MSH, 35, 256, 306 MUN-114, 85 muscimol, 159 muzolimine, 321 myoinositol-1,4,5-triphosphate, 216, 218 nadolol, 7 nafazatrom, 247 n a f t i f i n e (SN 105-8431, 133, 134 nalbuphine, 6 NECA, 288 n e o c a r z i n o s t a t i n , 141 neurotensin, 34 n i t r a r a C , 138 nitrazepam, 14 n i t r e f a z o l e , 322 n i t r e n d i p i n e , 289 2 -0-nit ro- 1-B-D-arabinofuranosylc y t o s i n e ( n i t r a r a - c ) , 138 n i c a r d i p i n e , 64, 96, 98, 289 n i f e d i p i n e , 7 , 63, 64, 98, 289 n i l e p r o s t , 86 nimodipine, 7 , 64, 98 nogalamycin, 142 norfemoxitine, 158 n o r f l o x a c i n , 322
332 -
COMPOUND NAME AND CODE NUMBER INDEX
northienamycin, 110 novobiocin, 143 NTA-194 ( t i a r a m i d e l , 97 n y s t a t i n , 131 1 ,25- (OH2 1D3 ( l a,25-dihydroxyvitamin D ) , 179-187 1,23,15-(OH)3-24-oxo-D 180 la-25-(OH)2-24-oxo-D3, ' 182 1,25-(OH)2-24-0~0-D , 180 23s ,25- (OH )2-D3, 180 23,25-(OH)224-oxo-D , 182 25-0H-D3-26,23-lact&1e, 180 25,26-(0H) -D 180 OKY 1581, 2873' omerprazole (H 168/68), 84 ONO-2235, 173 OPC-8212, 76 ORG 2766 (ACTH4-91, 35 oxamniquine, 149 oxaprozin, 322 oxatomide (R 35,4431, 96 oxiconazole (Ro 13-89961, 132, 133, 322 36 oxiracetam (ISF-2522), oxitropium bromide, 323 oxmetidine, 82 oxybutynin, 274 6-oxo-PGFla, 277 p ar ath io n e , 4, 206 p a r o x e t i n e , 289 PAT, 54 PD 112,548, 75 pencycuron, 273 p e n g ito x in , 71 p e r g o l i d e , 66 2-( perhydro-l,4-thiazepin-4-y1)e th y lb e n z yl e t h e r , 150 p e r meth r in ic a c i d , 267 PFA (phosphonoformic a c i d ) , 123 PGD2, 296 PGE1, 296 phenezine , 276 phenidone, 246 3-phenoxypyridine (CI-8441, 36 phenylmethanesulphonyl f l u o r i d e , 215 PHNO, 285 phosphonoformic a c i d (PFA), 123
phosphatidylinositol-4,5-bisphosp h ate , 213, 214, 217, 218 phosphatidyl inositol-4-monophosphate, 213, 214, 217, 218 phosphatidyl s e r i n e , 213 p ic o p r azo le (H 149/94), 84 p i f l u t h i x o l , 47 pimobendan (UD-CG 1151, 75 p i n a c i d i l , 63 p in d o lo l, 7 p i p o t h i a z i n e p a l m i t a t e , 21
piracetam, 31, 36 p i r b u t e r o l , 74 pi renzepi ne, 84, 286 p i r i b e d i l , 159 p i v a l o p r i l (RHC 36591, 6 PK 8165, 15 PK 9084, 15 PLG, 35 PL017, 2 3-PPP, 53, 285 pramiracetam (CI-879), 36 p r a z o s i n , 42, 45, 56, 285 p r e n a l t e r o l , 73, 274 PRH-836-EA, 97 probi crom i l (FPL 586881, 97 progabide (SL 760021, 16, 27 proglumide, 88 promegestone, 323 propachl or, 274, 276 N-propylnorapomorphine, 57 p r o s t a c y c l i n , 318 PY-108-068, 64 pyrazofuran, 137 pyrrolomycin, 130 QM 7184, 21, 22 q u e r c i t r i n , 172, 175 3-qui nucl i di nyl b e n z i l a t e (QNB), 286 qui pazi ne, 53 q u i s q u a l i c a c i d , 287 R14827 (econazol e), 131-133 R14889 (miconazole), 127-129; 131-133 R24571, 132 R 35,443 (oxatomide) , 96 R42470 ( t e r c o n a z o l e ) , 129 R51211 ( i t r a c o n a z o l e ) , 128 r a n i t i d i n e , 81, 82 rauwolscine, 51 ravidomycin, 141 RDS 127, 158, 159, 285 13-cis r e t i n o i c a c i d (RO 4-37801, 95 RHC 3288, 97 RHC 3659 ( p i v a l o p r i l ) , 62 r i b a v i r i n , 117, 119, 137
-
2-~-D-ribofuranosylthiazole-4-carboxamide 2 ( t i a z o f u r a n ) , 137 ri m ant adi ne, 118 RMI 15,37 1 ( 1 (5-tetradecyloxy2-furanyl)ethanone), 122 R M I 82,249, 77 Ro 2-9915 (5-fl uorocyt osi ne, f l u c y t o s i n e ) , 127, 133 Ro 4-3780 ( 1 3 - e r e t i n o i c a c i d ) , 95 RO 5-3663, 14 RO 5-4864, 14, 288 Ro 09-0410 (4'-ethoxy-2'-hydroxy4,6'-dimethoxychalcone), 121
-
COMPOUND NAME AND CODE NUMBER INDEX Ro 09-0179 (4' ,5-dihydroxy-3,3' ,7t r i m e t h o x y f l a v o n e ) , 121 Ro 13-5057 ( a n i r a c e t a m ) , 36
RO 13-6298, 143 Ro 13-8996 ( o x i c o n a z o l e ) , 132, 133 RO 15-1903, 110 RO 15-1788, 13, 14, 288 RO 16-8714, 165 RO 17-2301 (AMA-1080), 107 RO 22-0654, 163 RO 22-1319, 27 RO 22-6600, 23 Ro 216,937 ( t r i m o p r o s t i l ) , 86 RS-533, 109 RS 21361, 51, 56 RSD-127, 53 RU 24969, 54 RU 25591, 158 R X 781094, 51, 285 SA 446, 62 s a f r a c i n A, 140 s a f r a m y c i n R , 140 s a l b u t a m o l , 43 s a l i n o m y c i n , 152 sangivamycin, 138 s a p o n i n e , 216 SC-4453, 71 SC-30552, 65 sc 29333 ( m i s o p r o s t i l ) , 86 SC 30249, 86 SC 38390 ( z i n o c o n a z o l e ) , 128, 129 Sch 23390, 27, 285 Sch 28080, 85 Sch 30566, 129 Sch 31153, 129 Sch 31498, 129 Sch 31,846, 62 s e l e n a z o l e , 119 s e r t r a l i n e , 42 SF-1623, 109 SF 86-327, 129, 130, 133 SKF 10047, 288 SKF 38393, 21, 158, 159 SKF 82515, 66 SKF 86466, 51 SKF 88046, 96 SKF 93319, 83, 98 SM-4470, 129 SN 105-843 ( n a f t i f i n e ) , 133, 134 Sodium 5-aminosulfonyl-2,4-dichlorob e n z o a t e (M12325), 122 sodium c e l l u l o s e phosphate, 323 sodium h e x a c h l o r o i r i d a t e , 139 sodium v a l p r o a t e , 16 s o m a t o s t a t i n , 34, 88, 296, 305 s o r b i n i l (CP 45,6341, 170-172 s p i p e r o n e , 284, 286 s p o r i o f u n g i n s A, B d( C, 130, 131 spirogermanium, 153
26,917, 28,502, 28,503, SQ 28,332,
SQ
SQ SQ
333 -
107 107 107 107
s t r e p t o n i g r i n , 137 s u b s t a n c e P, 1 , 34 s u f e n t a n i l , 323 s u l c o n a z o l e , 133 s u l i n d a c , 173 s u l m a z o l e (AR-L 1151, 77 s u l p i r i . d e , 24 s u l v e r a p r i d e , 25 s u p r o f e n , 6, 324
TA064, 73
t e f l u d a z i n e , 23 t e r c o n a z o l e (R424701, 129, 324 1-(5-tetradecyloxy-2-furanyl)e t h a n o n e , (RMI 15,7311, 122 t e t r a h y d r o c a n n a b i n o l , 278 3,3a,5,llb-tetrahydro-7-hydroxy5-propyl-2H-fur0 [3,2-b]naphtho[2,3-d]pyran-2,6,11-trione, 152 thiazinamium c h l o r i d e , 99 thiorphan, 1
THIP, 5, 15, 16, 159 THPO, 16 t i a n e p t i n e , 324 t i a p a m i l , 289 t i a p r i d e (FLO 13471, 26 t i a r a m i d e (NTA-1941, 97 t i b a l o s i n e , 66 t i m i p e r o n e (DD-34801, 23, 24 t i o c o n a z o l e (UK 20,3491, 129, 133, 324 t i o t i d i n e , 55, 82, 288 t i o x a p r o f e n , 1.30 t i r o p r a m i d e , 324 TL-99, 51, 53, 285 t7-OBQ, 53 t o c a i n i d e , 274 t o l r e s t a t (AY-27,773), 173 tomazepam, 14 t r a c a z o l a t e , 15 (n-5')tranilast, 96 t r a p i d i l , 100 t r a z o d o n e , 45, 46, 289
TRH, 34
t r i c l a b e n d a z o l e (CGA-893171, 151 t r i f l u a d o m , 160 t r i f l u o p e r a z i n e , 47, 216 t r i m a z o s i n , 66 t r i m i p r a m i n e , 84 t r i m o p r o s t i l (Ro 216,9371, 86 t r o p a p r i d e (MD 790501), 26
TSH, 296 U-42,585E (lodoxamide tromethamine), 97 U-54537 E, 26 U-54,669F, 67
334 -
COMPOUND NAME AND CODE NUMBER INDEX
U-60257, 95, 247 UD-CG 115 (pimobendan), 75 UK 14,275 ( b u q u i n e r a n ) , 75 UK-14,304, 51 UK 20,349 ( t i o c o n a z o l e ) , 129, 133 UK 36,327, 75 ursodeoxycholic acid, 273 v a l c o n a z o l e (Bay 87511, 134 v a l p r o i c a c i d , 274, 278 v a s o p r e s s i n , 304 v e r a p a m i l , 96, 98, 278, 289 v i l o x a z i n e ( I C I 58 ,834) , 45 y - v i n y l GABA, 159 V I P , 34 virenomycin, 14 1 VP-16 (4'demethylepipodophyllotoxin9- (4 ,6-O-ethylidine-f3-D-glucop y r a n o s i d e ) ) , 141 WB-4101, 67 WHR-1370, 85 Win 38,020 ( a r i l d o n e ) , 122 Win 44,441, 161 Win 48,049, 63 Win 49,321, 122 Wy 26392, 51 Wy 26703, 51 Wy 44221, 62 x a m o t e r o l ( I C I 118,5871, 74 YC-93 ( n i c a r d i p i n e h y d r o c h l o r i d e ) , 96 YM-08050, 24 YM-09151-2, 24 z a p r i n a s t (M h B 229481, 97 z e t i d o l i n e (DL-308) , 27 z i m e l i d i n e (M 102/09), 42, 4 4 , 45, 46, 158 z i n o c o n a z o l e (SC 383901, 128, 129 ZK 36,374, 62 Z K 91296, 17 z o f e n o p r i l , 62 zomepirac, 6 z o p i c l o n e , 16
AA-861, 95 acetohydroxamic a c i d , 31 a c i v i c i n , 138 a c r i h e l l i n , 72 acy l o v i r , 122 C-c'Ado ( c a r b o c y c l i c 3-deazaadenos i n e , 120 adrenorphin, 2 a d r i a m y c i n , 142 AF64A ( e t h y l c h o l i n e mustard a z i r i dinium i o n ) , 32 a f l o q u a l o n e , 274, 313 AH 22216 ( L a m t i d i n e ) , 82 AH 23844 ( L o x t i d i n e ) , 82 a l b u t e r o l , 74 a l f e n t a n i l , 314 a l m i n o p r o f e n , 3 14 a l p i r o p r i d e (Riv 20931, 25 a l p r a z o l a m , 14 alprenolol, 7 a l r e s t a t i n (A4-22,284), 171, 172 a l t h i o m y c i n , 152 107 AMA-1080 (RO 17-2101), a m a n t a d i n e , 117, 118 a m d i n o c i l l i n ( m e c i l l i n a m ) , 109 b i s (5-amidino-2-benzimidazolyl) methane, 120 1 - a m i n o b e n z o t r i a z o l e , 20 3'-amino-2' , 3 ' - d i d e o x y c y t i d i n e , 138 2-amino-6,7-dihydroxybenzonorbornene, 51 6 - a m i n o l a e v u l i n i c a c i d , 55, 57 3-aminopropane s u l p h o n i c a c i d , 55 4-aminopyridine, 32 a m i s u l p r i d e (DAN 2163) , 25 amoxapine (CL 67,7721, 44 a m p h o t e r i c i n B , 127, 13.1-133 amrinone, 7 6 , 314 AMSA (4'-[ ( g - a c r i d i n y l ) a m i n o ] m e t h a n e - s u l p h o n - p a n i s i d i d e l , 143 androst-4-ene-3,17-dione, 208 a n i r a c e t a m (Ro 13-50571, 30 APB (2-amino-4-phosphonoheptanoic a c i d ) , 287 APP 201-533, 76 ARA-A, 123 ARA-C, 138 a r a c h i d o n i c a c i d , 214, 218 a r e c o l i n e , 32 a r g i n i n e v a s o p r e s s i n , 304 a r i l d o n e (Win 38,0201, 122 AR-L 115, 77 arugomycin, ( s u l m a z o l e ) , 142 ASI-222, 71
-
ANNUAL REPORTS IN MEDICINAL CHEMISTRY- 19
327 -
ASL-7022, 51, 7 3 a s p a r t a m e , 267 a s t e r n i z o l e , 98, 314 a t r i a l n a t r i u r e t i c f a c t o r , 253 a t r i o p e p t i n I , 67 a t r i o p e p t i n 11, 67 a u r a n o f i n , 314 auromomycin, 141 avermectin B l a ' 147 avermectin B 147 a x i l l a r i n , ?it; AY-22,284 ( a l r e s t a t i n ) , 171, 172 AY-27,773 ( t o l r e s t a t ) , 173 p - a z i d o b e n z y l c a r a z o l o l , 286 a z l o c i l l i n , 109 A1 34U [2,6-diamino-9-(2-hydroxye t h o x y m e t h y l ) p u r i n e ] , 123 A25822B, 131 A 32799, 25 BABIM [bis(5-amidino-2-benzimida z o l y l ) m e t h a n e , 120 b a c a m p i c i l l i n , 109 b a c l o f e n , 5 , 287 Bay-b-5097 ( c l o t r i m a z o l e ) , 127, 129, 131, 133 Bay-h-4502 ( b i f o n a z o l e ) , 127, 134 Bay k 8644, 65, 7 6 , 289 Bay-1-9139, 127, 128 Bay-n-7133, 127, 128 Bay n 2920, 163. Bay n 4605, 162 Bay o 1248, 162 Bay o 8278, 95 Bay 8751 ( v a l c o n a z o l e ) , 134 BD40, 143 BDF 6143, 51 BE 2254 (HEAT), 285 b e f u n o l o l , 315 bendazac, 173 benoxaprofen, 247 b e n z o t r i p t , 88 b e n z y l c h o l i n e mustard, 286 N-benzyl-1-(methy1)cyclopropyl amine, 205 4-(o-benzylphenoxy)-N-methylbutylamine H C 1 (MCI-20161, 32 b e p r i d i l , 98 b e t a x o l o l , 315 BHT, 274 B-HT 920, 51, 5 3 B-HT 933, 51 b i c u c u l l i n e , 287 b i f o n a z o l e (Bah-h-45021, 127 , 134, 315 b i s a n t r e n e , 143
Copyright 0 1984 by Academic Press, Inc. All rights of reproduction in any form reserved. ISBN 0-12-0405 19-9
328 BL 5255,
COMPOUND NAME AND CODE NUMBER INDEX
97 bleomycin, 139, 140 BM-5, 57 BMY-25260 (L-643,44 1 ) , 82 BMY-25368, 82 BMY-28 14 1, 109 bombesin, 160 bone r e s o r p t i o n f a c t o r , 236 bremazocine, 160, 288 BRL 20330, 109 BRL-20596, 24 BRL 20627, 24 BRL 22321, 97 BRL 268308, 165 bromocryptine, 57 2-bromolisuride, 27 brotizolam, 315 budesonide, 100, 273 budralazine, 63, 315 a-bungarotoxin (BTX) , 287 buprenorphine, 6 bupropion, 158 buquineran ( U K 14,275 1 75 burimamide, 55 buspirone, 15 butaclamol, 21 butoconazole, 133 bu topamine, 73 b u t y l flufenamate, 3 6 BVDU, 123 BW 245C, 62 BW 357U, 159 BW 683C. ( 4 ' ,6-dichloroflavan), 121 BW-755C, 246 BW 825C, 98 C-19393H2 (carpetimycin A ) , 110 cadexomer i o d i n e , 316 c a r d r a l a z i n e ( I S 24691, 63 carpetimycin C , 110 carpetimycin D , 110 c a l c i t r o i c a c i d , 180 calmodulin, 215 c a p t o p r i l , 278 c a r a z o l o l , 285 carbamazepine, 16 carbamylcholfne, 216 carbazeran, 75 carbocy l i c 3-deazaadenosine (C-c 9Ado), 120 carpetimycin A (C-19393H2), 110 c a r z i n o p h i l i n , 141 CCK, 34 CCK-4, 160 CCK-8, 160, 161 cehenoxime, 3 16 cefotaxime, 107 cefoperazone, 109 c e f o t e t a n , 109 ceftazidime, 109, 316
cefuroxime a x e t i l , 108 c e l i p r o l o l , 317 c e r u l e t i d e , 160 CG 4203, 62 CG 10213-90, 154 CGA 64151 (etaconazole), 131 CGA-89317 ( t r i c l a b e n d a z o l e ) , 151 CGP 11109, 25 CGP 12177, 286 CGP 28392, 289 CGS 8216, 13, 15 CGS 9896, 15, 288 CGS 10746 B , 22 CGS 13,945, 62 CGS 14,825A, 62 CGS 14,831 62 chenodiol, 317 chlorambucil, 138 ( - ) - t h r e o - c h l o r o c i t r i c acid, 161 c h o l a c a l c i o i c acid, 181 CI-844 (3-phenoxypyridine) , 36 CI-879 (pramiracetam), 36 CI-914, 75 c i c l a z i n d o l , 164 ciclopiroxolamine (HOE-2961, 134 c i l a s t a t i n (MK0791 1, 110 4-(Cinnamylthio)l-@-D-ribofuranoxyl1H-pyrazole [3,4-d]pyrirnidine, 152 c i m e t i d i n e , 81, 82 ciramadol, 6 cisapride (R 516191, 24 citalopram, 54 CL 115,347, 62 CL 115,574, 86 CL 218,872, 12, 13, 15, 288 c l e n b u t e r o l (NAB 3651, 43 clobazam, 14 c l o f i b r a t e , 208 c l o r a z e p a t e , 14 clomipramine ( G 345861, 42, 44, 46 clonazepam, 288 c l o n i d i n e , 5, 56 c l o p e n t h i x o l deconoate, 21 c l o t r i m a z o l e (Bay-b-50971, 127, 129, 131, 133 clovoxamine, 278 clozapine, 21, 44 CM 40874, 108 CM 57373, 158 CM 57493, 158 CN-146, 130 a-CNA, 3 B-CNA, 3 c7-OBQ, 53 compactin, 267, 269 coumermycin, 143 CP 45,634 ( s o r b i n i l ) , 170-172 cromolyn sodium (FPL 6701, 96, 97 cyanopindolol, 285
COMPOUND NAME AND CODE NUMBER INDEX
329
c y c l a r a d i n e , 123 2-(2,3-dimethylphenoxy)-methylc y c l i z i n e , 55 i m i d a z o l i n e , 1.49 c y c l o - ( a r g - g l y ) , 35 2-(2,3-dimethylphenyl)-2,3,5,6-tetrac y c l o s p o r i n e , 317 hydroimidazo[2,1-b]thiazole, 149 D-600, 64, 289 d i m e t r a c i n , 44 DA 4577, 83 d i p r e n o r p h i n e , 35, 161 DADLE , 6 , '288 N,N-dipropyl-2-amino-7-hydroxyDACO, 288 t e t r a l i n , 53 d a u n o r u b i c i n , 143 dobutamine., 73 . d a z o x i b e n , 101 domperidone, 34, 284 (DBE) d i h y d r o - b e t a - e r y t h r o i d i n e , 287 doxaminol, 74 DC-52, 140 DP-6,7-ADTN, 51 cis-DDP(*-diaminedichloroplatinum dynorphin, 2 111, 137, 139 dynorphin ( 1-8 1, 267 trans-DDP, 139 e c o n a z o l e (R148271, 131-133 DDAVP ( d e s m o p r e s s i n ) , 34 e l l i p t i c i n e , 143 10-deazaaminopterin, 137 e n a l a p r i l (MK-4211, 62 d e c i l o r u b i c i n , 142 @-endorphin, 2 , 4 d e l t a s l e e p - i n d u c i n g p e p t i d e , 16 e n k e p h a l i n , 1-3 , 6 denzimol, 17 e n o c i t a b i n e , 318 deoxynor j i r i m y c i n , 162, 163 e n p r o f y l l i n e , 100 dermorphin, 2 , 3 enviroxime (LY 122772 1, 120 3~-desamin0-3~-morpholinodaunorabicine p e r i s o n e , 318 (3'-MD), 142 4'epidoxorubicin, 137, 142 8-epi-thienamycin, 110 d e s m o p r e s s i n (DDABP), 34 dezocine, 6 e p o p r o s t e n o l , 3 18 DFMO._ _(DL-a-difluromethyl-ornithine) , e t a c o n a z o l e (CGA 64251), 131 153 e t a z o l a t e , 15, 288 DCAVP, 34 4'-ethoxy-2'hydroxy-4 , 6 -dimet h XYDHAQ, 143 c h a l c o n e (Ro 09-0410 , 121 2,5-diamino-9-2-(hydroxyethoxymethYl) e t o m i d a t e , 12, 16 p u r i n e (A134U1, 123 etonitazene, 3 3 , 4 - d i a m i n o p y r i d i n e , 32 e t h y l c h o l i n e mustard a z r i d i n i u m c i s -diamined i c h l o r o p l a t i n u m 11 i o n (AF64A), 32 , 137 ethylketocyclazocine, (*-DDP) 60 d i b e n y l i n e , 286 e t i n t i d i n e , 82 cis-dichloro-trans-dihydroxy-&etiracetam, 36 i s o p r o p y l a m i n e p l a t i n u m V I ( C H I P ) farnotidine, 82 139 FCE 20485, 108 4 1 6 - d i c h l o r o f l a v a n (BW683C), 121 FCE 22553, 109 2- ( 3 , 4 -d i c h l o r o phenoxy - 5 - n i t r o FCE 22891, 109 b e n z o n i t r i l e (MDL-860), 121 femoxetine, 45, 157 diclofenac, 7 f e n b u p r o l , 318 5,8-dideazaisopteroyltlutamate fendosal, 7 (IAHQ), 137 f e n f l u r a m i n e , 44, 157, 161, 162 diflunisal, 6, 7 f e n o c t i m i n e , 85 D L - a - d i f l u o r o m e t h y l o r n i t h i n e (DFMO), f e n o t e r o l , 74 153 f e n t a n y l , 273 d i ' h y d r o a l p r e n o l o l , 285 f i b r o n e c t i n , 236 147 FG 7142, 12 22,23-dihydroavermectin B l a , d i h y d r o e r g o t a m i n e , 7 , 42, 45, 56 FIAC, 123 4' ,5-dihydroxy-3,3' ,7-trimethoxyFK 027 (FR 17027), 108 f l a v o n e (Ro 09-0179), 121 FK 33-824, 88 FKK, 100 la,25-dihydroxyvitamin D [ ( 1 , 2 5 FLA 965 (OH) D 11, 179 18 1 FLB 13 1 , 25 24, R-25Zd?hydroxyvitamine D~ , d i l t i a z e m , 63, 64, 98, 289 f l o r d i p i n e , 64 d i m a p r i t , 55 f l u m e t h r i n , 151 f l u n a ri zi n e , 7
-
330
COMPOUND NAME AND CODE NUMBER INDEX
f lu n itr azep a m , 11, 14 c i s - f l u p e n t h i x o l (N-70091, 47 f l u p e r l a p i n e (NB 106-6891, 22 f lu p h en a zin e, 47 5 - f lu o r o c y to si ne (Ro 2-9915) ( f l u c y t o s i n e ) , 127, 133 f l u o x e t i n e , 42, 43, 4 4 , 45, 46 f lu r b ip r o p h e n, 7 f lu ta mid e, 318 fluvoxamine, 42, 3 19 FMAU, 123 FMLP (N-formylmethionyl-leucylp h en y la la ni ne) , 236 B-FNA, 3 B-FOA, 3 N-formimidoyl thienamycin, (imipenem, MK0787), 110 N-formylmethionyl-leucyl-phenyla l a n i n e (FMLP), 236 f o r s k o l i n , 76, 101, 293 FPL 670 (cromolyn sodium), 96, 97 FPL 52694, 85 FPL 55712, 93, 94, 96, 242, 244, 246-8 FPL 58668 ( p r o b i c r o m i l ) , 97 FPL 59257, 96 FR 17027 (FK 0271, 108 FR 34235, 65 FR 900318, 110 g a l l i a m n i t r a t e , 139 g allo p amil, 319 gemeprost, 319 g i l v o c a r c i n V , 141 g i t o f o r m a t e , 71 glucagon, 34 GP 50302, 22 guanadre 1, 3 19 g u an f a cin e, 277 G Y K l 13 380, 160 H-77, 61 H 149/94 ( p i c o p r a z o l e ) , 84 H 168/68 (omeprazole), 84 halofuginone, 154 halometasone, 320 halazepam, 14 HBB 2-(or-hydroxybenzyl)benzimidaz o l e , 120 HEAT (BE 22541, 285 HOE-040, 72 HOE-296 ( c ic l opi r oxol am i ne) , 134 HOE 892, 87 HR 375, 24 HR 810, 109 HRP 913, 23 hydrocortisone b u t y r a t e pr opi onat e, 320 4-hydroperoxy i f os f am i de, 138
4-hydroxyandrost-4-ene-3,17-dione, 27 3
2-(or-hydroxybenzyl)benzimidzole (HBB), 120 hydroxybenzylisoproterenol, 286 9- [2-hydroxy-l- (hydroxymethyl) ethoxymethyllguanine, 123 7-hydroxy-methotrexate (7-OH M T X ) , 137 B-hydroxy-B-methylglutaric a c i d , 321 erythro-9-(2-hydroxy-3-nonyl)adeni ne, 16 25-hydroxy-10-oxo-19-norvitamin D 3' 183 ibopamine, 73 ibuprophen, 6 ICI-105,552, 172, 173 ICI-1 18.587 (xamoterol), 74 ICI-128 ;436, 173 ICI-14'1,292, 67 ICI-153,066, 128, 131 idazoxan ( R X 7810941, 51 ifosfamide, 138 IL-2 ( i n t e r l e u k i n 2 ) , 191-198 imipenem (N-formimidoyl t hi enamycin, MK07871, 110 i n d a l p i n e , 320 i n t e r l e u k i n - 2 (IL-21, 191-198, 236 indoprophen, 6 iodohydroxybenzylpindolol, 285 i prat ropi um , 98, 99 i p r i n d o l e , 42, 43, 4 4 , 45, 47 IPS 339, 285 ISF 2469 ( c a d r a l a z i n e ) , 63 1 ~ ~ - 2 5 2 2(oxi racet am ), 36 i soconazol e, 131-133 2-isopropyl-4-pentenarnide (AIA), 201, 207 isoxicam, 320 i t r a c o n a z o l e (R512111, 128 i verm ect i n, 147 JPC-60-36, 158, 159 JPC-211, 158, 159 K-351, 67 KB-944, 65 KB-1585, 109 KC-404, 96 k e t a n s e r i n , 65, 286 ketoconazole, 127-1 34 k i j a n i m i c i n , 142 KF-4942, 66 KY-087, 108 KY-109, 108 L-640,876, 109 L-643,441 (BMY-25260), 82, 288 1,644,440, 109 L646,591, 109 labetalol, 6 laidlomycin, 152 l a m t i d i n e (AH222161, 82 LC-6, 95
-
COMPOUND NAME AND CODE NUMBER INDEX
308 l i s i n a p r i l (MK-521), 62 l i t o r i n , 160 lodoxamide tromethamine (U-42,585E), 97 loprazolam, 1 4 , 321 lorazepam, 14 loxapine, 44 l o x i t i d i n e (AH 238441, 82 l o z i l u r e a , 88 4R,5S,6Z-2-nor LTD1, 248 LUR 2366, 25 LY 53857, 65 LY 79771, 165 LY 81067, 17 LY 104119, 165 LY 122771 (enviroxime), 120 LY 141865, 21, 66 M-7, 51 M-83 [7-N-(p-hydroxyphenyl)mitomycin-Cl, 140 M 79175, 172 M12325 (Sodium 5-aminosulfonyl2,4-dichlorobenzoate), 122 macrocortin, 216 m a p r o t i l i n e (Ba-34,276), 42 m a r i n a c t i n , 142 mazindol, 164 MB11008, 159 M & B 22,948 ( z a p r i n a s t ) , 97 MCI-2016 (4-(o-benzy1phenoxy-Nmethylbutylamine H C L ) , 32, 84 McN-A-343, 286 MD 781124, 25 MDL 646, 86 MDL-860 (2-(3,4-dichlorophenoxy)5-nitrobenzonitrile), 121 MDL 899, 63 MDL-17,043, 77 MDL-19,205, 77 mebendazole, 149, 150 mecamylamine, 287 mecillinam ( a m i n o c i l l i n ) , 109 mefloquine, 153 meglutol, 321 a-melanotropin, 306 merpacrine, 317 m e p r o s c i l l a r i n , 72 meptazinol, 6, 288, 321 metergoline, 53 N-methyl-D-aspartate ( N M D A ) , 287 cis-methyldilvasene, 286 N-methyl-4-piperidinyl b e n z i l a t e , 286 m e t i t e p i n e , 53 metkephamid, 6 metorphamide, 2 m e z l o c i l l i n , 109 mianserin, 43, 4 4 , 45, 56, 84, 286 LHRH,
33 1 -
miconazole (R148891, 127-129, 131133 midazolam, 5 , 14 milbemycin, 148 milenperone (R 34009), 23 milrinone, 76 minoxidil o - s u l f a t e , 63 m i s o p r o s t i l (SC29333), 86 mitocymin c , 140 mitoxantrone, 137, 143 MJ 13805, 15 MJ 13859, 23 M J 13980-1, 26 MK 212, 290 MK-401, 151 MK-421 ( e n a l a p r i l ) , 62 MK-521 ( l i s i n a p r i l ) , 62 MK 801, 290 MK 0787 IN-formimidoyl thienamycin, (imipenem)], 110 MK 0791 ( c i l a s t a t i n ) , 110 MM 4550, 110 MM 13902, 109, 110 MM 17880, 110 monensin, 152 morantel, 150 morphiceptin, 2 moxalactam, 107 MPE Fe 11, 137 MPV295, 66 M r 1452, 161 Mr 2034, 2 M r 2266, 161 CI-MSH, 35, 256, 306 MUN-114, 85 muscimol, 159 muzolimine, 321 myoinositol-1,4,5-triphosphate, 216, 218 nadolol, 7 nafazatrom, 247 n a f t i f i n e (SN 105-8431, 133, 134 nalbuphine, 6 NECA, 288 n e o c a r z i n o s t a t i n , 141 neurotensin, 34 n i t r a r a C , 138 nitrazepam, 14 n i t r e f a z o l e , 322 n i t r e n d i p i n e , 289 2 -0-nit ro- 1-B-D-arabinofuranosylc y t o s i n e ( n i t r a r a - c ) , 138 n i c a r d i p i n e , 64, 96, 98, 289 n i f e d i p i n e , 7 , 63, 64, 98, 289 n i l e p r o s t , 86 nimodipine, 7 , 64, 98 nogalamycin, 142 norfemoxitine, 158 n o r f l o x a c i n , 322
332 -
COMPOUND NAME AND CODE NUMBER INDEX
northienamycin, 110 novobiocin, 143 NTA-194 ( t i a r a m i d e l , 97 n y s t a t i n , 131 1 ,25- (OH2 1D3 ( l a,25-dihydroxyvitamin D ) , 179-187 1,23,15-(OH)3-24-oxo-D 180 la-25-(OH)2-24-oxo-D3, ' 182 1,25-(OH)2-24-0~0-D , 180 23s ,25- (OH )2-D3, 180 23,25-(OH)224-oxo-D , 182 25-0H-D3-26,23-lact&1e, 180 25,26-(0H) -D 180 OKY 1581, 2873' omerprazole (H 168/68), 84 ONO-2235, 173 OPC-8212, 76 ORG 2766 (ACTH4-91, 35 oxamniquine, 149 oxaprozin, 322 oxatomide (R 35,4431, 96 oxiconazole (Ro 13-89961, 132, 133, 322 36 oxiracetam (ISF-2522), oxitropium bromide, 323 oxmetidine, 82 oxybutynin, 274 6-oxo-PGFla, 277 p ar ath io n e , 4, 206 p a r o x e t i n e , 289 PAT, 54 PD 112,548, 75 pencycuron, 273 p e n g ito x in , 71 p e r g o l i d e , 66 2-( perhydro-l,4-thiazepin-4-y1)e th y lb e n z yl e t h e r , 150 p e r meth r in ic a c i d , 267 PFA (phosphonoformic a c i d ) , 123 PGD2, 296 PGE1, 296 phenezine , 276 phenidone, 246 3-phenoxypyridine (CI-8441, 36 phenylmethanesulphonyl f l u o r i d e , 215 PHNO, 285 phosphonoformic a c i d (PFA), 123
phosphatidylinositol-4,5-bisphosp h ate , 213, 214, 217, 218 phosphatidyl inositol-4-monophosphate, 213, 214, 217, 218 phosphatidyl s e r i n e , 213 p ic o p r azo le (H 149/94), 84 p i f l u t h i x o l , 47 pimobendan (UD-CG 1151, 75 p i n a c i d i l , 63 p in d o lo l, 7 p i p o t h i a z i n e p a l m i t a t e , 21
piracetam, 31, 36 p i r b u t e r o l , 74 pi renzepi ne, 84, 286 p i r i b e d i l , 159 p i v a l o p r i l (RHC 36591, 6 PK 8165, 15 PK 9084, 15 PLG, 35 PL017, 2 3-PPP, 53, 285 pramiracetam (CI-879), 36 p r a z o s i n , 42, 45, 56, 285 p r e n a l t e r o l , 73, 274 PRH-836-EA, 97 probi crom i l (FPL 586881, 97 progabide (SL 760021, 16, 27 proglumide, 88 promegestone, 323 propachl or, 274, 276 N-propylnorapomorphine, 57 p r o s t a c y c l i n , 318 PY-108-068, 64 pyrazofuran, 137 pyrrolomycin, 130 QM 7184, 21, 22 q u e r c i t r i n , 172, 175 3-qui nucl i di nyl b e n z i l a t e (QNB), 286 qui pazi ne, 53 q u i s q u a l i c a c i d , 287 R14827 (econazol e), 131-133 R14889 (miconazole), 127-129; 131-133 R24571, 132 R 35,443 (oxatomide) , 96 R42470 ( t e r c o n a z o l e ) , 129 R51211 ( i t r a c o n a z o l e ) , 128 r a n i t i d i n e , 81, 82 rauwolscine, 51 ravidomycin, 141 RDS 127, 158, 159, 285 13-cis r e t i n o i c a c i d (RO 4-37801, 95 RHC 3288, 97 RHC 3659 ( p i v a l o p r i l ) , 62 r i b a v i r i n , 117, 119, 137
-
2-~-D-ribofuranosylthiazole-4-carboxamide 2 ( t i a z o f u r a n ) , 137 ri m ant adi ne, 118 RMI 15,37 1 ( 1 (5-tetradecyloxy2-furanyl)ethanone), 122 R M I 82,249, 77 Ro 2-9915 (5-fl uorocyt osi ne, f l u c y t o s i n e ) , 127, 133 Ro 4-3780 ( 1 3 - e r e t i n o i c a c i d ) , 95 RO 5-3663, 14 RO 5-4864, 14, 288 Ro 09-0410 (4'-ethoxy-2'-hydroxy4,6'-dimethoxychalcone), 121
-
COMPOUND NAME AND CODE NUMBER INDEX Ro 09-0179 (4' ,5-dihydroxy-3,3' ,7t r i m e t h o x y f l a v o n e ) , 121 Ro 13-5057 ( a n i r a c e t a m ) , 36
RO 13-6298, 143 Ro 13-8996 ( o x i c o n a z o l e ) , 132, 133 RO 15-1903, 110 RO 15-1788, 13, 14, 288 RO 16-8714, 165 RO 17-2301 (AMA-1080), 107 RO 22-0654, 163 RO 22-1319, 27 RO 22-6600, 23 Ro 216,937 ( t r i m o p r o s t i l ) , 86 RS-533, 109 RS 21361, 51, 56 RSD-127, 53 RU 24969, 54 RU 25591, 158 R X 781094, 51, 285 SA 446, 62 s a f r a c i n A, 140 s a f r a m y c i n R , 140 s a l b u t a m o l , 43 s a l i n o m y c i n , 152 sangivamycin, 138 s a p o n i n e , 216 SC-4453, 71 SC-30552, 65 sc 29333 ( m i s o p r o s t i l ) , 86 SC 30249, 86 SC 38390 ( z i n o c o n a z o l e ) , 128, 129 Sch 23390, 27, 285 Sch 28080, 85 Sch 30566, 129 Sch 31153, 129 Sch 31498, 129 Sch 31,846, 62 s e l e n a z o l e , 119 s e r t r a l i n e , 42 SF-1623, 109 SF 86-327, 129, 130, 133 SKF 10047, 288 SKF 38393, 21, 158, 159 SKF 82515, 66 SKF 86466, 51 SKF 88046, 96 SKF 93319, 83, 98 SM-4470, 129 SN 105-843 ( n a f t i f i n e ) , 133, 134 Sodium 5-aminosulfonyl-2,4-dichlorob e n z o a t e (M12325), 122 sodium c e l l u l o s e phosphate, 323 sodium h e x a c h l o r o i r i d a t e , 139 sodium v a l p r o a t e , 16 s o m a t o s t a t i n , 34, 88, 296, 305 s o r b i n i l (CP 45,6341, 170-172 s p i p e r o n e , 284, 286 s p o r i o f u n g i n s A, B d( C, 130, 131 spirogermanium, 153
26,917, 28,502, 28,503, SQ 28,332,
SQ
SQ SQ
333 -
107 107 107 107
s t r e p t o n i g r i n , 137 s u b s t a n c e P, 1 , 34 s u f e n t a n i l , 323 s u l c o n a z o l e , 133 s u l i n d a c , 173 s u l m a z o l e (AR-L 1151, 77 s u l p i r i . d e , 24 s u l v e r a p r i d e , 25 s u p r o f e n , 6, 324
TA064, 73
t e f l u d a z i n e , 23 t e r c o n a z o l e (R424701, 129, 324 1-(5-tetradecyloxy-2-furanyl)e t h a n o n e , (RMI 15,7311, 122 t e t r a h y d r o c a n n a b i n o l , 278 3,3a,5,llb-tetrahydro-7-hydroxy5-propyl-2H-fur0 [3,2-b]naphtho[2,3-d]pyran-2,6,11-trione, 152 thiazinamium c h l o r i d e , 99 thiorphan, 1
THIP, 5, 15, 16, 159 THPO, 16 t i a n e p t i n e , 324 t i a p a m i l , 289 t i a p r i d e (FLO 13471, 26 t i a r a m i d e (NTA-1941, 97 t i b a l o s i n e , 66 t i m i p e r o n e (DD-34801, 23, 24 t i o c o n a z o l e (UK 20,3491, 129, 133, 324 t i o t i d i n e , 55, 82, 288 t i o x a p r o f e n , 1.30 t i r o p r a m i d e , 324 TL-99, 51, 53, 285 t7-OBQ, 53 t o c a i n i d e , 274 t o l r e s t a t (AY-27,773), 173 tomazepam, 14 t r a c a z o l a t e , 15 (n-5')tranilast, 96 t r a p i d i l , 100 t r a z o d o n e , 45, 46, 289
TRH, 34
t r i c l a b e n d a z o l e (CGA-893171, 151 t r i f l u a d o m , 160 t r i f l u o p e r a z i n e , 47, 216 t r i m a z o s i n , 66 t r i m i p r a m i n e , 84 t r i m o p r o s t i l (Ro 216,9371, 86 t r o p a p r i d e (MD 790501), 26
TSH, 296 U-42,585E (lodoxamide tromethamine), 97 U-54537 E, 26 U-54,669F, 67
334 -
COMPOUND NAME AND CODE NUMBER INDEX
U-60257, 95, 247 UD-CG 115 (pimobendan), 75 UK 14,275 ( b u q u i n e r a n ) , 75 UK-14,304, 51 UK 20,349 ( t i o c o n a z o l e ) , 129, 133 UK 36,327, 75 ursodeoxycholic acid, 273 v a l c o n a z o l e (Bay 87511, 134 v a l p r o i c a c i d , 274, 278 v a s o p r e s s i n , 304 v e r a p a m i l , 96, 98, 278, 289 v i l o x a z i n e ( I C I 58 ,834) , 45 y - v i n y l GABA, 159 V I P , 34 virenomycin, 14 1 VP-16 (4'demethylepipodophyllotoxin9- (4 ,6-O-ethylidine-f3-D-glucop y r a n o s i d e ) ) , 141 WB-4101, 67 WHR-1370, 85 Win 38,020 ( a r i l d o n e ) , 122 Win 44,441, 161 Win 48,049, 63 Win 49,321, 122 Wy 26392, 51 Wy 26703, 51 Wy 44221, 62 x a m o t e r o l ( I C I 118,5871, 74 YC-93 ( n i c a r d i p i n e h y d r o c h l o r i d e ) , 96 YM-08050, 24 YM-09151-2, 24 z a p r i n a s t (M h B 229481, 97 z e t i d o l i n e (DL-308) , 27 z i m e l i d i n e (M 102/09), 42, 4 4 , 45, 46, 158 z i n o c o n a z o l e (SC 383901, 128, 129 ZK 36,374, 62 Z K 91296, 17 z o f e n o p r i l , 62 zomepirac, 6 z o p i c l o n e , 16