COMPOUND NAME, CODE NUMBER AND SUBJECT INDEX. VOL. 41
5HT2CR agonists, 88, 89 5HT6R antagonists, 90 n9-tetrahydrocannabinol, 78 A1 agonist, 175, 176 A-423579, 91 A-68930, 11 A-706149, 14 A-77636, 12 A-778193, 84 A-86929, 12 absorption kinetics, 385, 386 ACE inhibitors, 155, 157 ACE2, 192, 193 acetaminophen, 370, 371 acyl sulfonamide antiproliferatives (ASAP), 252, 253, 254, 260 adenosine, 175, 176 adenosine diphosphate (ADP), 142 adenosine triphosphate (ATP), 141 ADP, 143, 144 adrenaline, 245 adrogolide, 12 advair, 241, 245 ADX47273, 8 AG7088, 185, 186 AGI-1067, 200, 201, 206 alemcinal (ABT-229), 216 aliskiren, 158, 160, 161, 164 allergic conjunctivitis, 221, 222 allergic rhinitis, 221, 222, 224, 225, 227 allosteric modulators, 5, 8, 10 allylamines, 306 alosetron, 215 17-alpha-estradiol, 17-beta-estradiol, 52 altepase (Activase), 39 alvimopan, 217 ALX-5407, 7 amantadine, 288 ambroxol, 63 AMG-131, 108, 109 AMG-211, 135 amides, 131, 134 amino acids, 310 2-aminopyridine, 245 amiodarone, 177 amitriptyline, 59 AMPAkines, 5 angiotensin I, 156 angiotensin II, 155, 156 angiotensin receptor blockers, 155 angiotensin receptors, 156
angiotensinogen, 156, 157, 158 aniracetam, 5 5-HT6 Antagonists, 13 antalarmin, 31 anticolinergics, 386 antifungal drug, 312 anti-mitotic, 263, 264 antiretroviral (ARV), 279 apoptosis, 40, 42, 48 aprepitant, 31 ARBs, 157, 161 AR-C68397AA, 245 ARV, 279, 280, 282 aryl sulfones, 135 AS-601245, 48 asthma, 221, 222, 223 ATC0065, 34 ATC0175, 34 ATI-7505, 213 atilmotin, 216 atopic dermatitis, 221 ATP, 142, 143, 144 avian influenza, 275, 276, 277, 278, 284 avian influenza vaccine, 278 azoles, 300, 303, 304, 306 BAL8557, 397 benzenesulfonamides, 135 benzimidazole, 244 benzodioxane, 242 beta-adrenergic agonists, 386 bezafibrate, 103, 104 biaryl blockers, 67 BILA 2157 BS, 158 BIO 1211, 206 bioactivation, 370, 372, 374, 375, 376, 377, 378, 379 biofilm, 312 BMS-601027, 266 BO-653, 201, 202 budesonide, 245 buspirone, 376 BVT-14225, 131 BVT-2733, 130, 131 BW A868C, 223 capecitabine, 401 carbamazepine, 59 carbenoxolone, 130, 131 carbetocin (duratocin), 416, 417 carmoterol, 239 caspase-3, 40, 41 caspases, 40
479
480
Compound Name, Code Number and Subject Index. Vol. 41
CaV2.2, 69 CB1R antagonists, 78, 81, 92 CCI (Bennett), 62, 63, 64 cDNAs, 331, 332, 333, 334 CDPPB, 8 celgosivir, 403 CEP-7055, 397 CFA, 62, 64 chalcones, 203, 206 chemical semantic web, 430 chemical tools, 428 chemoattractant receptor-homologous molecule expressed on Th2 cells, 222 chemogenomics, 427, 428, 431 CHF-4226, 239 chlolecystokinin CCKa receptor agonists, 215 chloroquine, 194 chlorpromazine, 177 cisapride (R 51619), 211, 212, 213 C-Jun-N-Terminal Kinase (JNK1, JNK2, JNK3), 47, 48 CK0106023, 263 classification of human cancers, 323 clozapine, 371, 372 CLX-0921, 110, 111 CMK inhibitor, 185 combivent, 245 COMPARE analysis, 253, 256 coronavirus, 183, 184, 185, 187, 189, 191, 192, 193, 194, 195 corticosteroids, 386 corticosterone, 128, 129, 130, 134 cortisol, 128, 133 cortisone, 128, 129, 133, 134 covalent binding, 370, 371, 372, 373, 379 CP-122721, 31 CP-154526, 31 CPPHA, 8 CRA0450, 32 cromakalim, 177 CRTH2, 222, 224, 225, 226, 227, 228, 229, 230, 231 CRTH2 Agonists, 225 CRTH2 Antagonists, 224, 226, 227, 229, 230, 231 CRX000143, 110, 111 CX-516, 5 CX-717, 5 cyclopenta-[e]azepine-4,10(1H,5H)-diones, 257 cyclothiazide, 6 cytochrome P450, 326, 369, 370 cytochrome P450, mechanism-based inactivation of, 378 cytokines, 46 cytotoxic, 387
D prostanoid, 222 DANA, 288, 289, 292 decursin, 257, 260 11-dehydrocorticosterone, 128, 129 dehydrocorticosterone, 129 deposition, 384, 386 desvenlafaxine, 24 dexloxiglumide, 215 DFB, 8 diamides blockers, 63 diarylquinolone, 281 diclofenac, 375, 376, 378 dihydrexidine, 11 dinapsoline, 12 dinoxyline, 12 domperidone, 212 dopamine D1/D5 receptor agonists, 11 dopamine D2 receptor antagonists, 212 dopamine D3 receptor agonists, 13 DOV-216303, 25 DOV-21947, 25 DP, 222, 223, 224, 225, 226, 227, 229, 231 DP Antagonists, 223, 224, 225, 226 DP knock-out mice, 222, 231 DP1, 222 DP2, 222 DPQ, 42 drug metabolizing enzymes (DMEs), 325 duloxetine, 24 echinocandins, 307 edema, 50, 51 emerging infections, 275, 284 EPC-2407 (MX-116407), 257 erythromycin, 212, 216 estrogen receptor (ER), 52 estrogens, 51, 52 ethacrynic acid, 191 excitotoxicity, 40 exubera (inhaled insulin), 383, 389 F-98214-TA, 24 farnesoid X receptor, 99 fenofibrate, 46, 103, 105, 106 fentanyl, 384 finasteride, 371 FK614, 108, 109 FLIPR, 69 fluticasone, 241, 245 flux assay, 70 FMS586, 86 formalin, 62, 63, 64, 67, 68 formamides, 240 formoterol, 237, 239, 240, 241, 245, 246 fosamprenavir, 396 FR247304, FR257516, FR197262, FR142057, 44
Compound Name, Code Number and Subject Index. Vol. 41 frequency-dependence, 61 fructose-1-phosphate (F-1-P), 144 fructose-6-phosphate (F-6-P), 144 FXR, 111, 117, 118 G-6-P, 142, 143, 144 gatifloxacin, 280, 281 geldanamycin, 50 gemfibrozil, 103, 104 gene set enrichment analysis (GSEA), 321, 322 genetic screen, 331, 332, 333 genomic data mining, 319 GHSR antagonists, 83, 84, 85 GKA, 142, 145, 146, 147, 148, 149, 150, 151, 152 GKRP, 144, 145, 146, 152 glucokinase activator (GKA), 146, 149 glucokinase regulatory protein (GKRP), 144 glucose-6-phosphate (G-6-P), 141 glucose-stimulated insulin release (GSIR), 142 glutathione adduct, 372, 373, 374, 375, 376, 377, 378, 379 glycine antagonists, 53 18b-glycyrrhetinic acid, 128 glycyrrhizin, 193 GlyT1 Inhibitors, 6 GP-6150, 43 G-protein, 222, 229 G-protein coupled receptors (GPCRs), 409, 413 GS7340, 401, 402 GSIR, 142, 144, 146, 147 guggulsterone, 117, 118 GW0742, 104, 105 GW3965, 113, 114, 115 GW4064, 117, 118 GW501516, 104, 105 GW-610, 256, 257 GW695634, 397 H3R antagonists, 91, 92 H5N1, 287, 294 halofenate, 108 HDAC inhibitors, 312 hemorrhagic stroke, 39, 40 heparin, 387, 390 hepatotoxicity, 370, 375, 376, 378 herbimycin A, 50 hexokinase, 141, 142 HR22C16, 268 human ether-a-go-go related gene (hERG), 147 human genome sequence, 338, 339 HUN-7293, 202 hydrofluoroalkane, 239 5-hydroxy indole, 10 8-hydroxycarbostyril, 238, 239, 244 7b-hydroxycholesterol, 129 hydroxypyridine-2-thione, 190
481
5-hydroxytryptamine, 239 hyperglycemia, 147 hypertension, 155, 156, 157, 161 hypoglycemia, 146, 152 IDRA-21, 6 IFN, 194 IKr, 169, 170, 173, 174 IKs, 169, 170, 173, 174 IKur, 169, 170, 173 imipramine, 177 InChI, 429, 430 indacaterol, 238, 239 inductive logic programming, 433 inflammation, 45, 46, 47 inflammatory cells migration, 222 influenza, 287, 288, 289, 290, 291, 292, 293, 294 INO-1001, 42 interferon, 194 interferon-alpha, 387, 389, 390 ipratropium, 245 irbesartan, 109, 110 isatin derivatives, 188 ischemic stroke, 39, 40, 43, 46, 48, 49, 51 isoprenaline, 243 ispinesib, SB-715992/CK0238273, 264 Itopride, 211, 212 kaletra, 190 KC11458, 216 KCNA5, 170 7-ketocholesterol, 129 ketones, 135 knowledge-aided drug design, 432 KR-31378, 205 KRP 297, 47 KRP-297, 105, 106 Kv1.3, 170 Kv1.5, 169, 170, 171, 172, 173 L-152804, 87 L759274, 31 L-888839, 225 lactam, 134 lamotrogine, 59 LC-MS/MS, 370, 373, 376, 377 lenalidomide, 251 leuprolide, 387, 388, 389, 390 LG100268, 111 licofelone, 205 lidocaine, 62 liver X receptor, 99 LL3858, 282 LL4858, 282 lopinavir, 190 loxiglumide, 215 Lu 36-274, 27
482
Compound Name, Code Number and Subject Index. Vol. 41
lung metabolism, 386 luteolin, 193 LXR, 111, 112, 113, 114, 118 LY181837, 9 LY-2121260, 145 LY2140023, 9 LY341495, 9 LY353381, 52 LY354740, 9 LY404039, 9 LY404187, 6 LY465608, 47 LY487379, 9 LY544344, 400 LY573636, 252, 255 M1/M4 agonist, 14 M-826, M-867, 40, 41 macromolecules, 386, 387, 390 maturity-onset diabetes of the young (MODY-2), 152 MB243, 82 MBX-102, 108, 109 MC4R agonists, 81, 82 MCH1R antagonists, 82 MCL0042, 33 MCL0129, 33 MDL28170, 193 ME3229, 399 metabolism, 372, 379 metabolite, reactive, 370, 371, 372, 373, 374, 375, 376, 377, 378, 379 metabotropic glutamate receptors, 7 metaglidasen, 108 methimazole, 205, 206 methoxyfluoroquinolone, 279, 280 N-methyl-D-aspartate (NMDA) receptor, 50 methylnaltrexone, 217 metoclopramide, 211, 212 mexiletine, 59 mGluR2, 9 mGluR5, 8 microRNA, 319, 323 mitotic kinesin, 263, 264, 271 MK-0767, 106 MK-499, 67 model organisms, 337, 339, 340, 347 monastrol, 267, 268, 270, 271 morphine, 384, 386 mosapride, 213 motilin receptor agonists, 216 moxifloxacin, 279, 280, 281, 282 Mtb72F/AS02A, 283 muraglitazar, 105, 106 MVA85A, 283 MX-116407 (EPC-2407), 257, 259
myopathy, 103, 105 Na/Ca exchanger (NCX), 175 naloxone, 87 naltrexone, 87 natalizumab, 206 Nav1.2, 61, 63 Nav1.3, 61, 69 Nav1.5, 61, 63, 64 Nav1.7, 61, 62, 63, 64, 66, 67 Nav1.8, 61, 62, 63, 69, 70 Nav1.9, 61 naveglitazar, 105, 106 NBI-30775, 32 NBI-35965, 32 NCX, 175 NCX1, 175 nefazodone, 375, 376, 377, 378 nelarabine, 251 nelfinavir, 194 neuraminidase, 288, 290, 291, 292, 293, 294 neuraminidase inhibitors, 277 SH-SY5Y neuroblastoma cells, 68 neuroprotection, 39, 40, 42, 48, 52 neuroprotective agent, 39 niclosamide, 190, 194 nitroimidazoles, 281, 282 nitroimidazo-oxazole, 282 nitroimidazopyran, 281, 282 nitrolinoleic acid, 101 nitrooleic acid, 101 S-nitroso-N-acetylpenicillamine, 193 NNC 38-1049, 91 NPR-104, 403 NPTS, 7 NPY, 86, 86 NSC-686288 (TK-2339), 257, 258 NXY-059, 40 olanzapine, 372 oncogenic addiction, 342 ONO-2231, ONO-1924H, 43 ONO-4127.Na, 224 OPC-67683, 282 open chemistry, 428, 430 opioid antagonists, 53 opioid receptor antagonists, 87 m-opioid receptor antagonists, 217 oral glucose tolerance test (OGTT), 147, 148 orlistat, 78 oseltamivir, 277 oseltamivir, 288, 290, 293, 294 oxabispidine, 177 oxadiazole, 133 oxazoles, 135 oxazolones, 132 PA-824, 281, 282
Compound Name, Code Number and Subject Index. Vol. 41 PAT5a, 110 PD-173955, 50 PDE10A, 14 PDE4, 14 peptides, 383, 384, 385, 387 peramivir, 292, 294 permanent neonatal diabetes mellitus (PNDM), 152 peroxisome proliferator response elements, 100 peroxisome proliferator-activated receptors (PPARs), 45 peroxisome-proliferator-activated receptor, 99 persistent hyperinsulinemic hypoglycemia of infancy (PHHI), 152 PGD2, 221, 222, 223, 224, 225, 226, 227, 229, 230, 231, 232 PHA-543,613, 10 pharmacogenetics, 319, 325, 326, 328, 329 phasic block, 61 phenethyl, 242, 244 phenyloxyphenyl blockers, 65 phthalhydrazido, 187 pioglitazone, 45, 100, 101, 102, 109, 375 pivampicillin, 399 PJ34, 42 PNU, 190 PNU-120596, 10 PNU-282,987, 10 polanyi, 430 poly(ADP-ribose) polymerase-1 (PARP-1), 42, 43, 44 polyenes, 305 polypharmacology, 428 polypharmacy, 53 potassium channel activators, 53 PP, 78, 85, 86 PP1, PP2, 50 PPAR, 99, 100, 104, 107, 108, 111, 112, 118 preterm labor, 419 probucol, 199, 200, 201, 202 promazine, 190 prostaglandin D2, 221 protease, 184, 185, 186, 188, 190, 191, 194 prucalopride, 214 pumosetrag, 215 pyrazole, 133 pyrimidines, 309 pyrroles, 282 pyrrolidine, 135 pyrrolo [3,2-f]quinolin-9-one, 257 PYY, 87 PYY3-36, 85 QAB-149, 238 quetiapine, 372 quinolinones, 238
483
R121919, 31 R278995, 32 radicicol R3246, 50 ragaglitazar, 47, 105, 106 ralfinamide, 62 raloxifene, 374, 375, 378 ramatroban (BAY U3405), 222, 227 reactive metabolite, 355, 356, 360, 361 5-HT2C receptor agonists, 14 recombinant tissue plasminogen activator (rTPA), 39 relenza, 288, 293, 294 remikiren, 158 remofovir, 402 renin receptor, 157 renzapride, 213 replicase, 184, 185 retinoid X receptor, 99 rhinovirus, 185, 188 ribavirin, 194 Riccardin C, 114 rimantadine, 288 rimonabant, 78, 79, 80 ritonavir, 190 RO 42-5892, 158 Ro 60-0175, 30 RO0094889, 401 RO0661132, 161 RO0661168, 162 RO-27-5145, 145 RO-28-0450, 146 RO-28-1674, 146 RO-28-1675, 146 rosiglitazone, 45, 46, 100, 101, 102, 105, 106, 109, 110, 111 RS 102221, 30 RXR, 99, 100, 111, 112, 118 RY764, 82 S-5751, 223 saligenin, 241, 243, 245 salmeterol, 237, 238, 239, 241, 242, 243, 245, 246 sarcosine, 7 saredutant, 31 SARS, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195 SARS-CoV 3CLpro, 185, 186, 187, 188, 189, 190, 191, 194 SARS-CoV PLpro, 192, 194 SB-242084, 30 SB-269970, 30 SB-271046, 13 SB-414796, 14 SB-649915, 28 SB-656104-A, 30
484
Compound Name, Code Number and Subject Index. Vol. 41
SB-743921, 264, 266, 271 SC-47921, 159 SC-51106, 158, 159 SCH23390, 11 schizophrenia, 3 selective PPARg modulator, 108 serotonin 5HT3receptor agonists, 214 serotonin 5HT4 receptors agonists, 213 shRNA, 333 sibenadet, 245, 246 sibutramine, 78 signal transduction pathways, 340 siRNA, 323, 331, 333 SKF-38393, 11 SKF-812197, 11 SKI-606, 50, 51 SNAP-37889, 35 SNAP-398299, 35 SNAP-7941, 33 SNAP-94847, 34 SNL (Chung), 62 SNS-595, 251, 252, 255, 256 sodium channel blockers, 53 sorafenib, 251 sordarins, 310 SP-600125, 48 SPP100, 160 SPPARgM, 108, 109, 110 SQ 10,643, 191 src-family protein tyrosine kinases (SFKs), 50 SSR125543, 32 SSR126768A, 412, 413 SSR149415, 35 SSR180711A, 10 SSR-504734, 7 ST-280, 14 state dependence, 61 stroke, 39, 40, 42, 47, 49, 50, 52 sudoterb, 282, 283 sulfonamide, 244, 245 sulfonylureas, 147, 152 symbicort, 245 synthetic lethal interactions, 341 T0910792, 83 T0913659, 105, 104 T-131, 108, 109 T-1317, 113, 114, 116 TA-2005, 239 tacit knowledge, 430, 431, 432 tamiflu, 288, 293, 294 tamoxifen, 52 TD-5959, 246 tecadenoson, 176 tegaserod, 212, 214 telmisartan, 109, 110
tesaglitazar, 47, 106 tetrahydrocannabinoid, 384 tetra-O-galloyl-b-D-glugose, 193 tetrodotoxin, 60 TGEV 3CLpro, 185 thiadiazoles, 132 thiazoles, 131 thiazolidinediones (TZDs), 45 thiazolidinone, 100 thiazolones, 132 TIQ-A, 38, 43 TK-2339 (NSC-686288), 257 TMC207, 281 toxicity, idiosyncratic, 370, 372, 375, 379 toxicophore, 354, 355, 356, 357, 358, 360, 361, 362, 363, 365 transcriptional signature, 337 transporter, bile, 400, 403 transporter, Breast Cancer Resistant Protein, 399 transporter, monocarboxylate, 400 transporter, peptide, 400 transporter, sodium-dependent multivitamin, 401 trazodone, 376 triazole, 244 triazoles, 131, 133 N-(2-(trifluoro-methyl)-pyridin-4-yl) anthranilic ester, 257 troglitazone, 45, 100, 101 tuberculosis, 275, 278, 279, 280, 281, 282, 283, 284 tuberculosis vaccine, 283 TZD, 100, 101, 109, 110 TZD18, 106, 107 UC2, 190 V102862, 65 valacyclovir, 400 vascular endothelial growth factor (VEGF), 50 venlafaxine, 24 VER-2692, 14 veratridine, 68 VIPR, 67 WAY-161503, 30 WAY-163909, 14, 30 WIN-55,212-2, 204 XP13512, 400 Y2R agonists, 86 Y5R antagonists, 86 zafirlukast, 360 zanamivir, 277 zanamivir, 288, 289, 293, 294 zileuton, 360