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Contents
JOURNAL OF HEPATOLOGY VOLUME 54, ISSUE 3, PAGES 401–596 M. Nakagawa, M. Watanabe, M. Sakamoto, S. Maekawa, A. Sakai, S. Kaneko, K. Ito, N. Masaki, K. Tokunaga, N. Izumi, M. Mizokami
EDITORIALS 401
The quest for equity in liver transplantation: Another lesson learned from women. F. Durand
403
Long distance calling for liver regeneration: Identification of neuroendocrine signalling pathways activated after partial hepatectomy. M.A. Avila
406
Regulation of the expression of the hepatocellular sulfate–oxalate exchanger SAT-1 (SLC26A1) by glyoxylate: A metabolic link between liver and kidney? B. Stieger
RESEARCH ARTICLES Viral Hepatitis 408
415
422
432
439
449
Kinetics of hepatitis B surface antigen differ between treatment with peginterferon and entecavir. J.G.P. Reijnders, V. Rijckborst, M.J. Sonneveld, S.M.J. Scherbeijn, C.A.B. Boucher, B.E. Hansen, H.L.A. Janssen
Cirrhosis 455
Obliterative portal venopathy: Portal hypertension is not always present at diagnosis. D. CazalsHatem, S. Hillaire, M. Rudler, A. Plessier, V. Paradis, B. Condat, C. Francoz, M.-H. Denninger, F. Durand, P. Bedossa, D.C. Valla
Transplantation 462
Gender, renal function, and outcomes on the liver transplant waiting list: Assessment of revised MELD including estimated glomerular filtration rate. R.P. Myers, A.A.M. Shaheen, A.I. Aspinall, R.R. Quinn, K.W. Burak
Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b. T. Kawaoka, C.N. Hayes, W. Ohishi, H. Ochi, T. Maekawa, H. Abe, M. Tsuge, F. Mitsui, N. Hiraga, M. Imamura, S. Takahashi, M. Kubo, T. Tsunoda, Y. Nakamura, H. Kumada, K. Chayama
Liver Failure and Growth 471
Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients. C. Sarrazin, S. Susser, A. Doehring, C.M. Lange, T. Müller, C. Schlecker, E. Herrmann, J. Lötsch, T. Berg
The protective role of hydrogen-rich saline in experimental liver injury in mice. H. Sun, L. Chen, W. Zhou, L. Hu, L. Li, Q. Tu, Y. Chang, Q. Liu, X. Sun, M. Wu, H. Wang
481
Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis. I. Doignon, B. Julien, V. Serrière-Lanneau, I. Garcin, G. Alonso, A. Nicou, F. Monnet, M. Gigou, L. Humbert, D. Rainteau, D. Azoulay, D. Castaing, M.-C. Gillon, D. Samuel, J.-C. Duclos-Vallée, T. Tordjmann
489
The role of nucleoside and nucleotide analogues in nodular regenerative hyperplasia in HIVinfected patients: A case control study. L. Cotte, T. Bénet, C. Billioud, P. Miailhes, J.-Y. Scoazec, T. Ferry, C. Brochier, A. Boibieux, P. Vanhems, M. Chevallier, F. Zoulim
Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection. J.-I. Riezu-Boj, E. Larrea, R. Aldabe, L. Guembe, N. Casares, E. Galeano, I. Echeverria, P. Sarobe, I. Herrero, B. Sangro, J. Prieto, J.-J. Lasarte Pathogenesis of lipid metabolism disorder in hepatitis C: Polyunsaturated fatty acids counteract lipid alterations induced by the core protein. H. Miyoshi, K. Moriya, T. Tsutsumi, S. Shinzawa, H. Fujie, Y. Shintani, H. Fujinaga, K. Goto, T. Todoroki, T. Suzuki, T. Miyamura, Y. Matsuura, H. Yotsuyanagi, K. Koike Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors. M. Kurosaki, Y. Tanaka, N. Nishida, N. Sakamoto, N. Enomoto, M. Honda, M. Sugiyama, K. Matsuura, F. Sugauchi, Y. Asahina,
Cancer 497
Intratumoral neutrophils: A poor prognostic factor for hepatocellular carcinoma following resection. Y.-W. Li, S.-J. Qiu, J. Fan, J. Zhou, Q. Gao, Y.-S. Xiao, Y.-F. Xu
506
Pegylated interferon alpha targets Wnt signaling by inducing nuclear export of b-catenin. M.D. Thompson, M.J. Dar, S.P.S. Monga
therapies. M.B. Zeisel, I. Fofana, S. Fafi-Kremer, T.F. Baumert
Molecular and Cell Biology 513
521
Glyoxylate is a substrate of the sulfate-oxalate exchanger, sat-1, and increases its expression in HepG2 cells. N. Schnedler, G. Burckhardt, B.C. Burckhardt TGF-b1 mediated activation of Rho kinase induces TGF-b2 and endothelin-1 expression in human hepatic stellate cells. H. Shimada, N.R. Staten, L.E. Rajagopalan
Genetic and Metabolic Diseases 529
538
545
553
559
Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas. E. Mutel, A. Abdul-Wahed, N. Ramamonjisoa, A. Stefanutti, I. Houberdon, S. Cavassila, F. Pilleul, O. Beuf, A. Gautier-Stein, A. Penhoat, G. Mithieux, F. Rajas G80S-linked ferroportin disease: Classical ferroportin disease in an Asian family and reclassification of the mutant as iron transport defective. C.J. McDonald, D.F. Wallace, L. Ostini, S.J. Bell, B. Demediuk, V.N. Subramaniam Liver and pancreatic fat content and metabolism in healthy monozygotic twins with discordant physical activity. J.C. Hannukainen, R. Borra, K. Linderborg, H. Kallio, J. Kiss, V. Lepomäki, K.K. Kalliokoski, U.M. Kujala, J. Kaprio, O.J. Heinonen, M. Komu, R. Parkkola, M. Ahotupa, T. Lehtimäki, R. Huupponen, P. Iozzo, P. Nuutila Management of hepatocellular adenoma during pregnancy. J.E. Noels, S.M. van Aalten, D.J. van der Windt, N.F.M. Kok, R.A. de Man, T. Terkivatan, J.N.M. IJzermans Symptomatic-enlarging hepatic hemangiomas are effectively treated by percutaneous ultrasonography-guided radiofrequency ablation. S.Y. Park, W.Y. Tak, M.K. Jung, S.W. Jeon, C.M. Cho, Y.O. Kweon, K.C. Kim
SPECIAL SECTIONS International Hepatology 577
Combination of gemcitabine and cisplatin for biliary tract cancer: A platform to build on. N. Razumilava, G.J. Gores
579
Abnormal nitrosothiol metabolism in hepatocellular carcinoma. J. Martin, J.-F. Dufour
581
Platelet-derived chemokines: New targets to treat liver fibrosis. O. Morales-Ibanez, R. Bataller
Controversies in Hepatology 584
Rolls Royce for everybody? Diagnosing liver disease by mini-laparoscopy. A.W. Lohse
586
First-line assessment of patients with chronic liver disease with non-invasive techniques and without recourse to liver biopsy. T. Poynard
LETTERS TO THE EDITOR 588
Changes in the 24-h plasma cortisol rhythm in patients with cirrhosis. S. Montagnese, B. Middleton, A.R. Mani, D.J. Skene, M.Y. Morgan
590
Adrenal insufficiency: Diagnosis in patients with liver cirrhosis is difficult. A. Galbois, D. Thabut
591
Silibinin monotherapy prevents graft infection after orthotopic liver transplantation in a patient with chronic hepatitis C. S. Beinhardt, S. Rasoul-Rockenschaub, T.M. Scherzer, P. Ferenci
592
Silibinin in hepatitis C related liver transplantation. T. Berg, M. Biermer, UP. Neumann
593
Anemia – The overlooked factor in bleeding related to liver disease. J. Thachil
594
Anemia as a potential contributor to bleeding in patients with liver disease – Neglected but not forgotten. T. Lisman, S.H. Caldwell, R.J. Porte
REVIEW 566
Hepatitis C virus entry into hepatocytes: Molecular mechanisms and targets for antiviral
Registration of Clinical Trials The Journal of Hepatology endorses the policy of the WHO and the International Committee of Medical Journal Editors (ICMJE) on the registration of clinical trials. Therefore, any trial that starts recruiting on or after July 1, 2005 should be registered in a publicly owned, publicly accessible registry and should satisfy a minimal standard dataset. Trials that started recruiting before that date will be considered for publication if registered before September 13, 2005. More detailed information regarding clinical trials and registration can be found in New Engl J Med 2004; 351:1250– 1251 and New Engl J Med 2005; 352:2437–2438.
Cover image: Liver cell. Coloured scanning electron micrograph (SEM) of a hepatocyte. Magnification: 4,850 at 6 7 cm size. 16,000 at 7 9.5". (Source: Keystone/Science Photo Library SPL)
EDITORIALS 401
The quest for equity in liver transplantation: Another lesson learned from women. F. Durand
403
Long distance calling for liver regeneration: Identification of neuroendocrine signalling pathways activated after partial hepatectomy. M.A. Avila
406
Regulation of the expression of the hepatocellular sulfate–oxalate exchanger SAT-1 (SLC26A1) by glyoxylate: A metabolic link between liver and kidney? B. Stieger
RESEARCH ARTICLES Viral Hepatitis 408
415
422
432
439
449
Kinetics of hepatitis B surface antigen differ between treatment with peginterferon and entecavir. J.G.P. Reijnders, V. Rijckborst, M.J. Sonneveld, S.M.J. Scherbeijn, C.A.B. Boucher, B.E. Hansen, H.L.A. Janssen
Cirrhosis 455
Obliterative portal venopathy: Portal hypertension is not always present at diagnosis. D. CazalsHatem, S. Hillaire, M. Rudler, A. Plessier, V. Paradis, B. Condat, C. Francoz, M.-H. Denninger, F. Durand, P. Bedossa, D.C. Valla
Transplantation 462
Gender, renal function, and outcomes on the liver transplant waiting list: Assessment of revised MELD including estimated glomerular filtration rate. R.P. Myers, A.A.M. Shaheen, A.I. Aspinall, R.R. Quinn, K.W. Burak
Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b. T. Kawaoka, C.N. Hayes, W. Ohishi, H. Ochi, T. Maekawa, H. Abe, M. Tsuge, F. Mitsui, N. Hiraga, M. Imamura, S. Takahashi, M. Kubo, T. Tsunoda, Y. Nakamura, H. Kumada, K. Chayama
Liver Failure and Growth 471
Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients. C. Sarrazin, S. Susser, A. Doehring, C.M. Lange, T. Müller, C. Schlecker, E. Herrmann, J. Lötsch, T. Berg
The protective role of hydrogen-rich saline in experimental liver injury in mice. H. Sun, L. Chen, W. Zhou, L. Hu, L. Li, Q. Tu, Y. Chang, Q. Liu, X. Sun, M. Wu, H. Wang
481
Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis. I. Doignon, B. Julien, V. Serrière-Lanneau, I. Garcin, G. Alonso, A. Nicou, F. Monnet, M. Gigou, L. Humbert, D. Rainteau, D. Azoulay, D. Castaing, M.-C. Gillon, D. Samuel, J.-C. Duclos-Vallée, T. Tordjmann
489
The role of nucleoside and nucleotide analogues in nodular regenerative hyperplasia in HIVinfected patients: A case control study. L. Cotte, T. Bénet, C. Billioud, P. Miailhes, J.-Y. Scoazec, T. Ferry, C. Brochier, A. Boibieux, P. Vanhems, M. Chevallier, F. Zoulim
Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection. J.-I. Riezu-Boj, E. Larrea, R. Aldabe, L. Guembe, N. Casares, E. Galeano, I. Echeverria, P. Sarobe, I. Herrero, B. Sangro, J. Prieto, J.-J. Lasarte Pathogenesis of lipid metabolism disorder in hepatitis C: Polyunsaturated fatty acids counteract lipid alterations induced by the core protein. H. Miyoshi, K. Moriya, T. Tsutsumi, S. Shinzawa, H. Fujie, Y. Shintani, H. Fujinaga, K. Goto, T. Todoroki, T. Suzuki, T. Miyamura, Y. Matsuura, H. Yotsuyanagi, K. Koike Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors. M. Kurosaki, Y. Tanaka, N. Nishida, N. Sakamoto, N. Enomoto, M. Honda, M. Sugiyama, K. Matsuura, F. Sugauchi, Y. Asahina,
Cancer 497
Intratumoral neutrophils: A poor prognostic factor for hepatocellular carcinoma following resection. Y.-W. Li, S.-J. Qiu, J. Fan, J. Zhou, Q. Gao, Y.-S. Xiao, Y.-F. Xu
506
Pegylated interferon alpha targets Wnt signaling by inducing nuclear export of b-catenin. M.D. Thompson, M.J. Dar, S.P.S. Monga
therapies. M.B. Zeisel, I. Fofana, S. Fafi-Kremer, T.F. Baumert
Molecular and Cell Biology 513
521
Glyoxylate is a substrate of the sulfate-oxalate exchanger, sat-1, and increases its expression in HepG2 cells. N. Schnedler, G. Burckhardt, B.C. Burckhardt TGF-b1 mediated activation of Rho kinase induces TGF-b2 and endothelin-1 expression in human hepatic stellate cells. H. Shimada, N.R. Staten, L.E. Rajagopalan
Genetic and Metabolic Diseases 529
538
545
553
559
Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas. E. Mutel, A. Abdul-Wahed, N. Ramamonjisoa, A. Stefanutti, I. Houberdon, S. Cavassila, F. Pilleul, O. Beuf, A. Gautier-Stein, A. Penhoat, G. Mithieux, F. Rajas G80S-linked ferroportin disease: Classical ferroportin disease in an Asian family and reclassification of the mutant as iron transport defective. C.J. McDonald, D.F. Wallace, L. Ostini, S.J. Bell, B. Demediuk, V.N. Subramaniam Liver and pancreatic fat content and metabolism in healthy monozygotic twins with discordant physical activity. J.C. Hannukainen, R. Borra, K. Linderborg, H. Kallio, J. Kiss, V. Lepomäki, K.K. Kalliokoski, U.M. Kujala, J. Kaprio, O.J. Heinonen, M. Komu, R. Parkkola, M. Ahotupa, T. Lehtimäki, R. Huupponen, P. Iozzo, P. Nuutila Management of hepatocellular adenoma during pregnancy. J.E. Noels, S.M. van Aalten, D.J. van der Windt, N.F.M. Kok, R.A. de Man, T. Terkivatan, J.N.M. IJzermans Symptomatic-enlarging hepatic hemangiomas are effectively treated by percutaneous ultrasonography-guided radiofrequency ablation. S.Y. Park, W.Y. Tak, M.K. Jung, S.W. Jeon, C.M. Cho, Y.O. Kweon, K.C. Kim
SPECIAL SECTIONS International Hepatology 577
Combination of gemcitabine and cisplatin for biliary tract cancer: A platform to build on. N. Razumilava, G.J. Gores
579
Abnormal nitrosothiol metabolism in hepatocellular carcinoma. J. Martin, J.-F. Dufour
581
Platelet-derived chemokines: New targets to treat liver fibrosis. O. Morales-Ibanez, R. Bataller
Controversies in Hepatology 584
Rolls Royce for everybody? Diagnosing liver disease by mini-laparoscopy. A.W. Lohse
586
First-line assessment of patients with chronic liver disease with non-invasive techniques and without recourse to liver biopsy. T. Poynard
LETTERS TO THE EDITOR 588
Changes in the 24-h plasma cortisol rhythm in patients with cirrhosis. S. Montagnese, B. Middleton, A.R. Mani, D.J. Skene, M.Y. Morgan
590
Adrenal insufficiency: Diagnosis in patients with liver cirrhosis is difficult. A. Galbois, D. Thabut
591
Silibinin monotherapy prevents graft infection after orthotopic liver transplantation in a patient with chronic hepatitis C. S. Beinhardt, S. Rasoul-Rockenschaub, T.M. Scherzer, P. Ferenci
592
Silibinin in hepatitis C related liver transplantation. T. Berg, M. Biermer, UP. Neumann
593
Anemia – The overlooked factor in bleeding related to liver disease. J. Thachil
594
Anemia as a potential contributor to bleeding in patients with liver disease – Neglected but not forgotten. T. Lisman, S.H. Caldwell, R.J. Porte
REVIEW 566
Hepatitis C virus entry into hepatocytes: Molecular mechanisms and targets for antiviral
Registration of Clinical Trials The Journal of Hepatology endorses the policy of the WHO and the International Committee of Medical Journal Editors (ICMJE) on the registration of clinical trials. Therefore, any trial that starts recruiting on or after July 1, 2005 should be registered in a publicly owned, publicly accessible registry and should satisfy a minimal standard dataset. Trials that started recruiting before that date will be considered for publication if registered before September 13, 2005. More detailed information regarding clinical trials and registration can be found in New Engl J Med 2004; 351:1250– 1251 and New Engl J Med 2005; 352:2437–2438.
Cover image: Liver cell. Coloured scanning electron micrograph (SEM) of a hepatocyte. Magnification: 4,850 at 6 7 cm size. 16,000 at 7 9.5". (Source: Keystone/Science Photo Library SPL)