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Contents
TABLE OF CONTENTS
VOLUME 188, October 2017
Featured New Investigator Review Article 1
Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology, and therapeutic roles Yeawon Kim, Sun‑Ji Park, and Ying Maggie Chen, St. Louis, Mo
Full Length Articles 10
Nanoformulated copper/zinc superoxide dismutase exerts differential effects on glucose vs lipid homeostasis depending on the diet composition possibly via altered AMPK signaling Gopalakrishnan Natarajan, Curtis Perriotte‑Olson, Fatema Bhinderwala, Robert Powers, Cyrus V. Desouza, Geoffrey A. Talmon, Jiang Yuhang, Matthew C. Zimmerman, Alexander V. Kabanov, and Viswanathan Saraswathi, Omaha and Lincoln, Neb and Chapel Hill, NC
27
Blood-brain barrier–adapted precision medicine therapy for pediatric brain tumors Bernard L. Marini, Lydia L. Benitez, Andrew H. Zureick, Ralph Salloum, Angela C. Gauthier, Julia Brown, Yi‑Mi Wu, Dan R. Robinson, Chandan Kumar, Robert Lonigro, Pankaj Vats, Xuhong Cao, Katayoon Kasaian, Bailey Anderson, Brendan Mullan, Benjamin Chandler, Joseph R. Linzey, Sandra I. Camelo‑Piragua, Sriram Venneti, Paul E. McKeever, Kathryn A. McFadden, Andrew P. Lieberman, Noah Brown, Lina Shao, Marcia A. S. Leonard, Larry Junck, Erin McKean, Cormac O. Maher, Hugh J. L. Garton, Karin M. Muraszko, Shawn Hervey‑Jumper, Jean M. Mulcahy‑Levy, Adam Green, Lindsey M. Hoffman, Katie Dorris, Nicholas A. Vitanza, Joanne Wang, Jonathan Schwartz, Rishi Lulla, Natasha Pillay Smiley, Miriam Bornhorst, Daphne A. Haas‑Kogan, Patricia L. Robertson, Arul M. Chinnaiyan, Rajen Mody, and Carl Koschmann, Ann Arbor and Detroit, Mich; Lexington, Ky; Cincinnati, Ohio; New Haven, Conn; Denver, Colo; Seattle, Wash; Chicago, Ill; Washington, DC; and Boston, Mass
Original Articles 40
Evaluation of tolerance to lentiviral LV-RPE65 gene therapy vector after subretinal delivery in non-human primates Alexandre Matet, Corinne Kostic, Alexis‑Pierre Bemelmans, Alexandre Moulin, Serge G. Rosolen, Samia Martin, Fulvio Mavilio, Vazrik Amirjanians, Knut Stieger, Birgit Lorenz, Francine Behar‑Cohen, and Yvan Arsenijevic, Lausanne, Switzerland; Fontenay-aux-Roses, Asnières, Paris, Evry, France; and Giessen, Germany
58
Predicting thyroid nodule malignancy at several prevalence values with a combined Bethesda-molecular test Hélène Lasolle, Benjamin Riche, Myriam Decaussin‑Petrucci, Emmanuelle Dantony, Véronique Lapras, Catherine Cornu, Joël Lachuer, Jean‑Louis Peix, Jean‑Christophe Lifante, Oana‑Maria Capraru, Samia Selmi‑Ruby, Bernard Rousset, Françoise Borson‑Chazot, and Pascal Roy, Bron, Lyon, Villeurbanne, Pierre-Bénite, France, and Tirgu Mures, Romania
67
JAK-inhibitor tofacitinib suppresses interferon alfa production by plasmacytoid dendritic cells and inhibits arthrogenic and antiviral effects of interferon alfa Patrick P. C. Boor, Petra E. de Ruiter, Patrick S. Asmawidjaja, Erik Lubberts, Luc J. W. van der Laan, and Jaap Kwekkeboom, Rotterdam, The Netherlands
80
Phase 1–2 pilot clinical trial in patients with decompensated liver cirrhosis treated with bone marrow–derived endothelial progenitor cells Delia D'Avola, Verónica Fernández‑Ruiz, Francisco Carmona‑Torre, Miriam Méndez, Javier Pérez‑Calvo, Felipe Prósper, Enrique Andreu, José Ignacio Herrero, Mercedes Iñarrairaegui, Carmen Fuertes, José Ignacio Bilbao, Bruno Sangro, Jesús Prieto, and Jorge Quiroga, Pamplona, Spain
92
Contribution of glutaredoxin-1 to S-glutathionylation of endothelial nitric oxide synthase for mesenteric nitric oxide generation in experimental necrotizing enterocolitis Qingjuan Shang, Lei Bao, Hongjie Guo, Fabao Hao, Qianfu Luo, Jiaping Chen, and Chunbao Guo, Chongqing and Linyi, Shandong, People's Republic of China
Reader Services 4A
Author Guidelines
C3
Information for Readers Visit our website at www.translationalres.com
PUBLICATION INFORMATION: Translational Research: The Journal of Laboratory and Clinical Medicine (ISSN 1931-5244) is published monthly by Elsevier Inc., 230 Park Avenue, Suite 800, New York, NY 10169. Periodicals postage paid at New York, NY and additional mailing offices. USA POSTMASTER: Send address changes to Translational Research, Elsevier Health Sciences Division, Subscription Customer Service, 3251 Riverport Lane, Maryland Heights, MO 63043, USA.
VOLUME 188, October 2017
Featured New Investigator Review Article 1
Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology, and therapeutic roles Yeawon Kim, Sun‑Ji Park, and Ying Maggie Chen, St. Louis, Mo
Full Length Articles 10
Nanoformulated copper/zinc superoxide dismutase exerts differential effects on glucose vs lipid homeostasis depending on the diet composition possibly via altered AMPK signaling Gopalakrishnan Natarajan, Curtis Perriotte‑Olson, Fatema Bhinderwala, Robert Powers, Cyrus V. Desouza, Geoffrey A. Talmon, Jiang Yuhang, Matthew C. Zimmerman, Alexander V. Kabanov, and Viswanathan Saraswathi, Omaha and Lincoln, Neb and Chapel Hill, NC
27
Blood-brain barrier–adapted precision medicine therapy for pediatric brain tumors Bernard L. Marini, Lydia L. Benitez, Andrew H. Zureick, Ralph Salloum, Angela C. Gauthier, Julia Brown, Yi‑Mi Wu, Dan R. Robinson, Chandan Kumar, Robert Lonigro, Pankaj Vats, Xuhong Cao, Katayoon Kasaian, Bailey Anderson, Brendan Mullan, Benjamin Chandler, Joseph R. Linzey, Sandra I. Camelo‑Piragua, Sriram Venneti, Paul E. McKeever, Kathryn A. McFadden, Andrew P. Lieberman, Noah Brown, Lina Shao, Marcia A. S. Leonard, Larry Junck, Erin McKean, Cormac O. Maher, Hugh J. L. Garton, Karin M. Muraszko, Shawn Hervey‑Jumper, Jean M. Mulcahy‑Levy, Adam Green, Lindsey M. Hoffman, Katie Dorris, Nicholas A. Vitanza, Joanne Wang, Jonathan Schwartz, Rishi Lulla, Natasha Pillay Smiley, Miriam Bornhorst, Daphne A. Haas‑Kogan, Patricia L. Robertson, Arul M. Chinnaiyan, Rajen Mody, and Carl Koschmann, Ann Arbor and Detroit, Mich; Lexington, Ky; Cincinnati, Ohio; New Haven, Conn; Denver, Colo; Seattle, Wash; Chicago, Ill; Washington, DC; and Boston, Mass
Original Articles 40
Evaluation of tolerance to lentiviral LV-RPE65 gene therapy vector after subretinal delivery in non-human primates Alexandre Matet, Corinne Kostic, Alexis‑Pierre Bemelmans, Alexandre Moulin, Serge G. Rosolen, Samia Martin, Fulvio Mavilio, Vazrik Amirjanians, Knut Stieger, Birgit Lorenz, Francine Behar‑Cohen, and Yvan Arsenijevic, Lausanne, Switzerland; Fontenay-aux-Roses, Asnières, Paris, Evry, France; and Giessen, Germany
58
Predicting thyroid nodule malignancy at several prevalence values with a combined Bethesda-molecular test Hélène Lasolle, Benjamin Riche, Myriam Decaussin‑Petrucci, Emmanuelle Dantony, Véronique Lapras, Catherine Cornu, Joël Lachuer, Jean‑Louis Peix, Jean‑Christophe Lifante, Oana‑Maria Capraru, Samia Selmi‑Ruby, Bernard Rousset, Françoise Borson‑Chazot, and Pascal Roy, Bron, Lyon, Villeurbanne, Pierre-Bénite, France, and Tirgu Mures, Romania
67
JAK-inhibitor tofacitinib suppresses interferon alfa production by plasmacytoid dendritic cells and inhibits arthrogenic and antiviral effects of interferon alfa Patrick P. C. Boor, Petra E. de Ruiter, Patrick S. Asmawidjaja, Erik Lubberts, Luc J. W. van der Laan, and Jaap Kwekkeboom, Rotterdam, The Netherlands
80
Phase 1–2 pilot clinical trial in patients with decompensated liver cirrhosis treated with bone marrow–derived endothelial progenitor cells Delia D'Avola, Verónica Fernández‑Ruiz, Francisco Carmona‑Torre, Miriam Méndez, Javier Pérez‑Calvo, Felipe Prósper, Enrique Andreu, José Ignacio Herrero, Mercedes Iñarrairaegui, Carmen Fuertes, José Ignacio Bilbao, Bruno Sangro, Jesús Prieto, and Jorge Quiroga, Pamplona, Spain
92
Contribution of glutaredoxin-1 to S-glutathionylation of endothelial nitric oxide synthase for mesenteric nitric oxide generation in experimental necrotizing enterocolitis Qingjuan Shang, Lei Bao, Hongjie Guo, Fabao Hao, Qianfu Luo, Jiaping Chen, and Chunbao Guo, Chongqing and Linyi, Shandong, People's Republic of China
Reader Services 4A
Author Guidelines
C3
Information for Readers Visit our website at www.translationalres.com
PUBLICATION INFORMATION: Translational Research: The Journal of Laboratory and Clinical Medicine (ISSN 1931-5244) is published monthly by Elsevier Inc., 230 Park Avenue, Suite 800, New York, NY 10169. Periodicals postage paid at New York, NY and additional mailing offices. USA POSTMASTER: Send address changes to Translational Research, Elsevier Health Sciences Division, Subscription Customer Service, 3251 Riverport Lane, Maryland Heights, MO 63043, USA.