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Contents, index and list of previous review articles
CONTENTS
KINDLING MECHANISMS: CURRENT PROGRESS ON AN EXPERIMENTAL EPILEPSY MODEL DAN C. MCINTYRE* and R. J. RACINEt, *Department of Psychology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and tDepartment of Psychology, McMaster University, Hamilton, Ontario L8S 4KI, Canada NEUROBIOLOGY OF AN ANORECTIC DRUG FENFLURAMINE NElL E. ROWLAND and JANIS CARLTON, Department of Psychology and Center for Neurobiological Sciences, University of Florida, Gainesville FL 3261I, USA SOMATOSTATININ THE CENTRAL NERVOUS SYSTEM: PHYSIOLOGYAND PATHOLOGICAL MODIFICATIONS JACQUES EPELBAUM, U. 159 INSERM, Unit6 de Neuroendocrinologie, Centre Paul Broca, 2 ter, rue d'Al6sia, 75014 Paris, France
13
63
THE NEURONAL DETERMINANTSOF RESPIRATORY RHYTHM SUSAN LONG and JAMES DUFFIN, Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
101
SINGLE UNIT ACTIVITY OF Locus COERULEUS NEURONS IN BEHAVING ANIMALS BARRY L. JACOBS, Program in Neuroscience, Department of Psychology, Princeton University, Princeton, NJ 08544, USA
183
STUDIES ON THE OLFACTORY NERVOUS SYSTEMOF THE OLD WORLD MONKEY SADAYUKI F. TAKAGI, Department of Physiology, School of Medicine, Gunma University, Maebashi 371, Japan
195
SPROUTING AND REMODELLING AT THE NERVE-MUSCLE JUNCTION ANTON WERNIG* and ALBERT A. HERRERAt, *Department of Neurophysiology, University of Bonn, Wilhelmstrabe 31, D-5300 Bonn 1, West Germany tNeurobiology Section, Department of Biological Sciences, and Program in Neural, Informational and Behavioral Sciences, University of Southern California, Los Angeles, California 90089-0371, USA
251
FEEDING AND TASTE THOMAS R. SCOTT and GREGORY P. MARK, Department of Psychologyand Institute for Neuroscience, University of Delaware, Newark, DE 19716, USA
293
CARDIOVASCULAR EFFECTS OF ADENOSINE IN MAN, POSSIBLE CLINICAL IMPLICATIONS A. SOLLEVI, Department of Anesthesiology, Karolinska Hospital, and Department of Pharmacology, Karolinska Institutet, Box 60 400, S-104 01 Stockholm, Sweden
319
RESPONSES OF NEURONS IN ISOLATED PREPARATIONSOF THE MAMMALIAN CENTRAL NERVOUS SYSTEM HENRIK JAHNSEN, Institute of Neurophysiology, University of Copenhagen, Blegdamsvej 3c, DK-2200 Copenhagen N, Denmark
351
Related Journals of Interest
Advances in the Biosciences Current Advances in Endocrinology Current Advances in Neuroscience International Journal of Developmental Neuroscience Neurochemistry International Neuropharmacology Neuropsychologia Neuroscience Physiology and Behaviour Progress in Neuro-psychopharmacologyand Biological Psychiatry Psychoneuroendocrinology (flee specimen copy gladly sent on request)
INDEX Acetylcholine, action on hippocampal neurons 366 Acetylcholinesterase, abandoned synaptic gutters in muscle 253 Acromegaly, role of somatostatin 86 Activity, effect of fenfluramine 24 Adaption, locus coeruleus neuron activity 189 Adenosine, cardiovascular effects 319-349 in body fluids and tissues 321 clinical implications 343 exogenous, effects of 330 formation during ischaemia and hypoxia 325 quantitation 320 receptor antagonism 324 uptake inhibition 321 Adipose tissue, reactive hyperemia, adenosine 329 Aging, synaptic remodelling 262, 267, 268 Alzheimer's disease, somatostatin in brain 88 •,/-Aminobutyric acid, role in kindling 6 3/-Aminobutyric acid - - somatostatin colocalisation in brain 69 Amygdala cell response to odors 231 kindling 3, 5 Anaesthesia, myocardial blood flow and metabolism during 335, 344 Angina pectoris, adenosine formation 325 Anorexia, fenfluramine induced 21 Apneusis 103 Appetite suppressant 13-62 Arousal, locus coeruleus neuron activity 187 Asthma, role of adenosine 341 Atrioventricular conduction, role of adenosine 336, 343 Auditory stimuli, locus coeruleus neuron activity 186 Behaviour locus coeruleus neuron activity 185 effect ofsomatostatin 84 Behaviour modification, fenfluramine and weight loss 19 Blood flow cerebral, effect of adenosine 337 myocardial, effect of adenosine 335, 344 skeletal muscle, effect of adenosine 341 Blood pressure, effect of adenosine 344 Body temperature, effect of fenfluramine 38 Botzinger complex respiratory neurons 106, 114 late-peak expiratory neurons 162 Brain, adenosine formation during ischaemia 327 Brain stem, electroresponsive properties of isolated neurons 362 Bursting cell electroresponsive properties 358 kindling 3 CA1 pyramidal cell electroresponsive properties 353 effect of transmitters 366 CA3 pyramidal cell, electroresponsive properties 354 Carbohydrate intake, effect of fenfluramine 30 Carbohydrate metabolism, effect of fenfluramine 37
Carbon dioxide, expiratory cell discharge 156 Cardioplegia, adenosine formation 327 Carotid occlusion, adenosine formation 327 Catecholamines, role in kindling 6 Caudate nucleus retroambigualis 150 Centroposterior area of orbitofrontal cortex electrophysiology 218, 227 olfactory nerve pathways 211 olfactory representation 207 transthalamic olfactory pathway to 209 Cerebellum, electroresponsive properties of isolated neurons 360 Cerebral blood flow, effect of adenosine 337 Cerebrospinal fluid, adenosine in 321,327 Chemoreceptors, interaction with respiratory neurons 119, 134, 155 Cholecystokinin 311 Cholinergic-somatostatinergic innervations in cortex 88 Compensatory feeding behaviour 306 Conditioned taste aversion 304 effect of fenfluramine 31 Coronary graft occlusion, effect of adenosine 343 Coronary steal 335 Corticotropin-releasing hormone, fenfluraminestimulated release 39 Cranial nerves 115,134, 155 taste 294 Deep cerebellar nuclei cells, electroresponsive properties 361 Dementia, somatostatin in brain 88 Development somatostatin-containing neurons 70 synaptic remodelling 262, 267 Diazepam, locus coeruleus neuron activity 190 Diet selection, effect of fenfluramine 20, 30 5,6-Dihydroxytryptamine, fenfluramine anorexia 46 Dipyridamole, effect on adenosine levels in man 323 Disinhibition hypothesis of kindling 5 Dopamine antagonist action of fenfluramine 49 effect on hippocampal neurons 367 Dorsal horn neurons, electroresponsive properties 364 Early-burst inspiratory neurons 142 Energy wasting, effect of fenfluramine 37 Environment, locus coeruleus neuron activity Epilepsy model, kindling mechanisms 1-12 Expiratory neurons 151,162 Fast spiking celt, electroresponsive properties Feeding and taste 293-317 gustatory anatomy of the rodent 294 gustatory involvement in feeding 300 gustatory neural code 296 Fenfluramine behavioural effects acute anorexia 21 conditioned taste aversion 31
189
358
vi
INDEX
diet selection 30 discriminative stimulus properties 32 free feeding and tolerance to weight loss 26 obese rodent model 29 tolerance, cross-tolerance and set point 24 central mechanisms of action brain 5-hydroxytryptamine 40 dopamine 49 5-hydroxytryptamine-depleting lesion 46 5-hydroxytryptamine receptors 44 mechanisms of decreased 5-hydroxytryptamine levels 41 noradrenaline 50 opioids 50 peptides 51 clinical observations 18 metabolism 15 peripheral actions carbohydrate metabolism 37 gastric emptying and intestinal motility 32 gastric inhibition mechanism 34 gastro-intestinal 5-hydroxytryptamine 36 lipid metabolism 38 metabolic rate 37 pituitary-adrenal axis 39 structure 14 Food intake, effect of fenfluramine 20 Frog abandoned synaptic gutters 253 growth and age effects on synaptic remodelling 265 nerve sprouting and synapse formation 258
5-Hydroxytryptamine-depleting lesions, eflect c~i fenfluramine 46 5-Hydroxytryptamine receptors, effect ~-,r fenfluramine 44 Hypercapnia, expiratory cell discharge 156 Hypotension, effect of adenosine 330 Hypothalamic fibres, projection to prefrontal cortex 203 Hypothalamus, somatostatin secretion 71) Hypoxanthine formation during brain ischaemia 328 release from heart during angina pectoris 325 Hypoxia, adenosine formation 325
Gastric distension, taste 308 Gastric emptying, fenfluramine effects 32 Glossypharangeal nerve, taste 308 Glucose modulation of somatostatin release 74 taste 309 Graft occlusion, adenosine effects 343 Granule cells, electroresponsive properties 355 Growth, synaptic remodelling 262, 267 Growth hormone, modulation of somatostatin release 73 Gustatory anatomy of the rodent 294 Gustatory involvement in feeding 300 Gustatory neural code 296
Junctional modelling
Heart adenosine in 321 adenosine formation during ischaemia/hypoxia 325 clinical implications of adenosine 343 metabolism during anaesthesia, effect of adenosine 335 Hippocampus electroresponsive properties of isolated neurons 352 role in kindling 2, 5 effect of transmitters on neurons 365 Hunger, effect of fenfluramine 19 Huntington's disease, somatostatin in brain 87 5-Hydroxytryptamine in brain, effect of fenfluramine 40 effect on CNS neurons 367 gastrointestinal, effect of fenfluramine 36
Immunohistochemistry, somatostatin 66 Inferior olive, electroresponsive properties of neurons 362, 367 lnosine monophosphate, in skeletal muscle during ischaemia 328 Inspiratory neurons early-burst 142 late-peak 107, 126 upper cervical 167 Insulin, taste 309 Intestinal motility, fenfluramine effects 32, 35 Ischaemia, adenosine formation brain 327 heart 325 newborn infants 329 skeletal muscle and adipose tissue 328 Isolated brain preparations 352 252, 262
Kidney, effect of adenosine on function Kindling disinhibition hypothesis 5 epileptic neuron hypothesis 2 synaptic potentiation hypothesis 1 working hypothesis 9
337
Late-peak expiratory neurons 151, 162 Late-peak inspiratory neurons 107, 126 Lateral hypothalamic area cell response to odors 243 olfactory pathways to 236 Lateroposterior area of orbitofrontal cortex electrophysiology 217, 226 neural pathway to 199 olfactory area in 198 olfactory nerve pathways 211 Learning, locus coeruleus neuron activity 189 Limbic lesions, kindling 5 Lipid metabolism, effect of fenfluramine 38 Locus coeruleus neurons electroresponsive properties 363, 367 single unit activity in behaving animals 183-194 Long-term potentiation 2 Lung, effect of adenosine 341 Lung inflation, neuronal determinants 115, 134, 155, 169 Meal patterns, effect of fenfluramine 26
vii
INDEX Medulla, respiratory rhythm generation 101 Metabolic rate, effect of fenfluramine 37 N-Methyl-D-aspartate, effect on CNS neurons 367 Monkey(Macacca irus), olfactory nervous system 195-250 Morphine, locus coeruleus neuron activity 190 Motor endplate disease, synaptic remodelling 274 Multiple innervation 282 Muscle, skeletal adenosine in 321 adenosine effect on blood flow 341 adenosine formation during reactive hyperemia 328 aging 269 multiply innervated 282 synaptic remodelling 252, 265 Myasthenia gravis, synaptic remodelling 274
Neocortex, electroresponsive properties of isolated neurons 356 Neocortex, olfactory area cat 244 dog 242 monkey 198, 205, 214 rabbit 239 rat 246 Neocortex, olfactory nerve pathways 211 Neostriatum, electroresponsive properties of isolated neurons 358 Nerve-muscle junction, sprouting and remodelling 251-291 Neuromuscular diseases, synaptic remodelling 273 Neurons, isolated, electroresponsive properties 351-372 acetyicholine effects 365 brain stem 362 cerebellum 360 dopamine effects 367 hippocampus 352 neocortex 356 neostriatum 358 noradrenaline effects 366 spinal cord 364 thalamus 359 Neuropeptide Y - - somatostatin colocalisation in brain 69 Newborn infants, adenosine formation 329 Noradrenaline effect on hippocampal neurons 366 role in kindling 7 Noradrenergic neurons, single unit recording in behaving animals 183-194 Nucleus accumbens, neuron response to odors 236 Nucleus ambiguus 104, 126 Nucleus retroambigualis respiratory neurons 105 caudal 150 early-burst inspiratory neurons 142 late-peak inspiratory neurons 126 post-inspiratory neurons 146 rostral 126 Nucleus tractus solitarius 104, 107 taste ceils 294, 301,305, 308 Nutrition-toxicity, taste 303
Obesity, fenfluramine
18, 29
Odor behaviour studies 214 electrophysiology 217 Old world monkey, olfactory nervous system 195-250 Olfactory area, neocortex cat 244 dog 242 function of neurons 214 monkey 198, 205 rabbit 239 rat 246 Olfactory behaviour tests 214 Olfactory bulb, neuron response to odors 228 Olfactory nerve pathways, neocortex 211 Olfactory nervous system, monkey 195-250 behavioural studies 214 comparison with lower mammals 239 electrophysiological studies 217 lateral hypothalamic area 234, 236 neocortex 198 olfactory nerve pathways 211 thalamus 205 Opioids effect on CNS neurons 367 role in fenfluramine anorexia 51 Orbitofrontal cortex neuron function 214 olfactory area in 198,207 olfactory nerve pathways 211
Palatability 300 Parkinson's disease, somatostatin in brain 88 Pheochromocytoma surgery, effect of adenosine 334, 344 Pituitary, somatostatin receptors 75 Putuitary adenomas, role of somatostatin 86 Pituitary-adrenal axis, effect of fenfluramine 39 Plasticity of synaptic efficacy 275 Post-inspiratory neurons 146 Platelets, effect of adenosine 342, 344 Prepyriform cortex cell response to odors 231 olfactory pathways 293 Pulmonary stretch receptors 116 Purines, quantitation 320 Purkinje cell, electroresponsive properties 360 Pyriform cortex, burst generating cells 3
Rabbit, olfactory area in neocortex 239 Reactive hyperemia, role of adenosine 328 Rebound excitation, respiratory neurons 130 Remodelling, synaptic 252, 262 Regular spiking cells, electroresponsive properties 357 Renal function, effect of adenosine 337 Respiratory disturbances, newborn, adenosine involvement 330 Respiratory rhythm I01 Botzinger complex neurons 162 nucleus retroambigualis neurons 126 upper cervical respiratory neurons 168 ventrolateral nucleus tractus solitarius neurons 107 Rostral nucleus retroambigualis 126
INDEX
viii Satiety, receptors 308 Seasonal factors in synaptic remodelling 268 Seizure generation 1 Sensory stimuli, locus coeruleus neuron activity 186 Septum, neuron response to odors 235 Sick sinus syndrome, role of adenosine 336, 343 Sinus automaticity, role of adenosine 336, 343 Sleep, effect of fenfluramine 23 Sleep-wake cycle, locus coeruleus neuron activity 185 Smell discrimination, monkey 214 Sodium, consumption of 306 Somatostatin Alzheimer's disease and dementia 88 anatomical distribution 66 biosynthesis 64 coexistence with other neurotransmitters 69 Huntington's disease 87 inactivation in brain 83 mechanisms of action 78 multiple effects 84 pituitary adenomas 86 receptors in brain and pituitary 75 secretion and release 70 Spike-triggered averaging 160 Spinal cord electroresponsive properties of isolated neurons 364 respiratory rhythm generator 106 Sprouting and remodelling at the nerve-muscle junction 251-291 Stomach, effects of fenfluramine 32 Substance P, effect on CNS neurons 367 Synapse formation 258 Synaptic efficacy, plasticity and regulation 275 Synaptic gutters, abandoned 253 Synaptic potentiation hypothesis of kindling 1 Synaptic remodelling 252 effect of growth and age 265 neuromuscular diseases 273 Synaptic transmission, measures of 275
Taste 293-317 dimensions 300 gustatory anatomy of the rodent 294 gustatory neural code 296 plasticity of responses 303 Tetrodotoxin, effect on hippocampal neurons 354, 357 Thalamus cell responses to odors 233 electroresponsive properties of isolated neurons 359 olfactory input to 205 olfactory projection to prefrontal cortex 210 transthalamic olfactory pathway 209 Theophylline, effect on adenosine levels in vascular beds 324 Thermogenesis, diet-induced 38 Thyroid hormones, somatostatin regulation 78 Tolerance to fenfluramine 24 Tongue 295 Toxicity, taste 301 Transmitters, action on electrical membrane properties of central neurons 365
Tachycardias, effect of adenosine
Xylamidine
336, 343
Upper cervical respiratory neurons
167
Vasointestinal peptide, modulation of somatostatin release 72 Ventrolateral nucleus tractus solitarius respiratory neurons 104, 107 afferents 113 functional interrelations 112 location and morphology 107 patterns of activity 107 projections and synaptic connections 121 Visual stimuli, locus coeruleus neuron activity 186 Water intake, effect of fenfluramine 22 Weight loss, fenfluramine 18, 26 45
LIST OF PREVIOUS REVIEW ARTICLES VOLUME 1 R. PORTER G. J. MOGENSONand Y. H. HUANG K. KRISTENSSONand Y. OLSSON V. T. WYNN J. M. SNEDDON G. G. SOMJEN D. M. GUTHRIE, J. R. BANKSand E. SOMERVILLE
Functions of the mammalian cerebral cortex in movement The neurobiology of motivated behavior Diffusion pathways and retrograde axonal transport of protein tracers in peripheral nerves Absolute pitch in humans, its variations and possible connections with other known rhythmic phenomena Blood platelets as a model for monoamine-containing neurons Electrogenesis of sustained potentials Studies on the neural control of the skating reflex, and the origin of its variations in field population of the hemipterous insect
Gerris H. LABORIT J. S. DE BELLEROCHEand H. F. BRADFORD N. N. OSBORNE VOLUME2 J. R. BLOEDEL P. L. and E. G. McGEER G. I. DRUMMONDand Y. MA R. P. PETERSONand Y. P. LOH P. L. JEFFREY and L. AUSTIN G. PEPEU G. B. BIEDERMAN SHIN-ICHI TERASHIMAand R. C. GORIS VOLUME 3 U. PROSKE and R. M. A. RIDGE R. LAVERTY E. T. ROLLS DEFOREST MELLON A. OLIVERIO P. C. VAUGHAN W. J. McBRIDE and J. D. KLINGMAN VOLUME 4 J. W. JACKLETand K. LUKOWIAK P. A. ANNINGS H. KURIYAMA,N. TASHIRO and Y. ITO S. M. KIRPEKAR
G. F. GWILLIAMand R. MILLECCHIA W. P. BURKARD W. VAN DER KLOOT VOLUME 5 F. R. CALARESU,A. S. FAIERS and G. J. MOGENSON I. IZQUIERDO J. D. WOOD F. BAGUET B. YORK and C. A. G. WIERSMA M. F. MARMOR
Gamma-hydroxybutyrate, succinic semialdehyde and sleep The synaptosome: an isolated, working neuronal compartment The analysis of amines and amino acids in micro-quantities of tissue
Cerebellar afferent systems: a review Neurotransmitter synthetic enzymes Metabolism and functions of cyclic AMP in nerve The role of macro-molecules in neuronal function in Aplysia Axoplasmic transport The release of acetylcholine from the brain: an approach to the study of the central cholinergic mechanisms The search for the chemistry of memory: recent trends and the logic of investigation in the role of cholinergic and adrenergic transmitters Electrophysiology of snake infrared receptors
Extrafusal muscle and muscle spindles in reptiles On the roles of dopamine and noradrenaline in animal behaviour The neural basis of brain-stimulation reward Integrative and organizational aspects of synaptic function in molluscs Genetic and biochemical analysis of behavior in mice Muscle membrane Effects of excitation on the metabolism of a simple neuronal system--the mammalian sympathetic ganglion
Neural processes in habituation and sensitization in model systems The usefulness of artificial neural nets as models for the normal and abnormal functioning of the mammalian CNS On the physiological properties of neuromuscular junction and of obliquely striated muscle in the earthworm Factors influencing transmission at adrenergic synapses Barnacle photoreceptors: their physiology and role in the control of behaviour Adenylate cyclase in the central nervous system The timing of the appearance of miniature end-plate potentials
Central neural regulation of heart and blood vessels in mammals The hippocampus and learning The role of -y-aminobutyric acid in the mechanism of seizures Excitation and control of isolated photophores of luminous fishes Visual processing in the Rock Lobster (Crustacea) The membrane of giant molluscan neurons: electrophysiologic properties and the origin of the resting potential ix
LIST OF PREVIOUS REVIEW ARTICLES L. POIRIER,M. FILION, P. LANGLELIER and L. LAROCHELLS J. B. WILLIS T. J. HARA P. M. SELLICKand B. M. JOHNSTONE VOLUME6 W. R. KLEMM H. L. KLAWANSand W. J. WEINER R. R. DRUCKER-COLINand C. W. SPANIS E. EIDELBERG T. GORDON et al. A. R. FREEMAN M. STERIADEand A. A. HOnSON VOLUME7 M. C. WETZELand D. G. SWART N. KLEMM S. E. DYSONand D. G. JONES W. R. KLEMM A. J. SELVERSTON,D. F. RUSSELL,J. P. MILLER and D. G. KING H. L. ATWOOD VOLUME8 A. VAN HARREVELD LARS-G. ELFVlN C. M. LENT JON STORM-MATHISEN M. FILLENZ M. WILLIAMSand R. RODNIGHT
M. A. CORNER S. G. WAXMANand H. A. SWADLOW F. M. ACHEE, S. GABAYand K. F. TIerON D. E. SMITH VOLUME9 A. ANGEL F. V. DEFEUDIS D. G. AMARALand H. M. SINNAMON R. G. CURLESS R. A. LEVY VOLUME l0 A. A. BORBELY R. W. DYKES I. A. SYTINSKY,A. T. SOLDATENKOVand A. L~rraA J. A. DEUTSCH J. L. JOHNSON B. CSlLLIKand E. KNYIHAR
Brain nervous mechanisms involved in the so-called extra pyramidal motor and psychomotor disturbances A review of some of the models of the brain Olfaction in fish Production and role of inner ear fluid
Physiological and behavioural significance of hippocampal rhythmic, slow activity The pharmacology of choreatic movement disorders Is there a sleep transmitter? Possible action of opiates upon synapses Changes in chemosensitivity of skeletal muscles as related to endplate formation Polyfunctional role of glutamic acid in excitatory synaptic transmission Neuronal activity during the sleep-waking cycle
Ensemble characteristics of cat locomotion and its neural control Histochemistry of putative transmitter substances in the insect brain Undernutrition and the developing nervous system Hippocampal EEG and information processing: a special role for theta rhythm The stomatogastric nervous system: structure and function of a small neural network Organization and synaptic physiology of crustacean neuromuscular systems
Pharmacology of the vertebrate retina The ultrastructure of neuronal contacts The retzius cells within the central nervous system of leeches Localization of transmitter candidates in the brain: The hippocampal formation as a model The factors which provide short-term and long-term control of transmitter release Protein phosphorylation in nervous tissue: possible involvement in nervous tissue function and relationship to cyclic nucleotide metabolism Sleep and the beginnings of behaviour in the animal kingdom-studies of ultradian motility cycles in early life The conduction properties of axons in central white matter Some aspects of monoamine oxidase activity in brain The effect of deafferentation on the development of brain and spinal nuclei
Processing of sensory information GABA-receptors in the vertebrate nervous system The locus coeruleus: neurobiology of a central noradrenergic nucleus Development patterns of peripheral nerve myoneural junction and muscle The role of GABA in primary afferent depolarization
Effects of light on sleep and activity rhythms The anatomy and physiology of the somatic sensory cortical regions Neuroehemical basis of the therapeutic effect of 7-aminobutyric acid and its derivatives The stomach in food satiation and the regulation of appetite The excitant amino acids glutamic and aspartic acid as transmitter candidates in the vertebrate central nervous system Biodynamic plasticity in the Rolando substance
LIST OF PREVIOUS REVIEW ARTICLES J. L. S. COBBand V. W. PENTREATH
E.M. LANDAU VOLUME 1 1 Y. KUDO K. KUBA and K. KOKETSU E. HEILBRONN and T. BARTFAI H. MCILWAIN G. BURNSTOCK P. KOMET1ANI,Z. KOMETIANIand D. MIKELADZE K. S. KRISHNA MURTHY Translated by R. WERMAN VOLUME 12 C. D. BARNESand J. C. SCHADT C. H. HOCKMAN, D. BIEGERand A. WEERASURIYA S. REDMAN A. ROUTTENBERG T. RADOJCIC and V. W. PENTREATH E. S. Vizl G. G. YARBROUGH VOLUME 13 P. M. SALTZMANand R. H. ROTH P. C. EMSON A. NISTRI and A. CONSTANTI M. ISRAEL, Y. DUNANT and R. MANARANCHE L. HERTZ K. E. MOORE and S. M. X,VUERTHELE W. A. MACKAY and J. T. MURPHY J. O'KEEFE VOLUME 14 G. A. KERKUT T. SATO G. J. MOGENSON, D. L. JONES and C. Y. YIM C. B. GUNDERSEN n . SHINOZAKI N. MCNAUGHTONand S. T. MASON A. DRAY VOLUME 15 F. A. HENN and S. W. HENS D. G. JONES and B. J. SMITH A. J. WlLKINS, C. D. BINNIE and C. E. DARBY J. PARNAS, L. GRAM and H. FLACHS
Comparison of the morphology of synapses in invertebrate and vertebrate nervous systems: Analysis of the significance of the anatomical differences and interpretation of the morphological specializations Function and structure of the ACh receptor at the muscle end-plate
The pharmacology of the amphibian spinal cord Synaptic events in sympathetic ganglia Muscarinic acetylcholine receptor Synaptic mediators and the structuring of cerebral activity Do some sympathetic neurones synthesize and release both noradrenaline and acetylcholine? 3', Y-AMP-dependent protein kinase and membrane ATPases of the nerve cell Vertebrate fusimotor neurones and their influences on motor behavior Let us build a nervous system (A fragment of an allegedly ancient Hebrew manuscript reputedly found in the Judean desert)
Release of function in the spinal cord Supranuclear pathways of swallowing Junctional mechanisms at group Ia synapses Anatomical localization of phosphoprotein and glycoprotein substracts of memory Invertebrate glia Presynaptic modulation of neurochemical transmission On the neuropharmacology of thyrotropin releasing hormone (TRH)
Role of impulse flow in the short-term regulation of norepinephrine biosynthesis Peptides as neurotransmitter candidates in the mammalian CNS Pharmacological characterization of different types of GABA and glutamate receptors in vertebrates and invertebrates The present status of the vesicular hypothesis Functional interactions between neurones and astrocytes I. Turnover and metabolism of putative amino acid transmitters Regulation of nigrostriatal and tuberoinfundibular-hypophyseal dopaminergic neurons Cerebellar modulation of reflex gain A review of the hippocampal place ceils
Can fibre optic systems drive lower motoneurones? Recent advances in the physiology of taste cells From motivation to action: Functional interface between the limbic system and the motor system The effects of botulinum toxin on the synthesis, storage and release of acetylcholine The pharmacology of the excitatory neuromuscular junction in the crayfish The neuropsyehoiogy and neuropharmacology of the dorsal ascending noradrenergic bundle--A review The physiology and pharmacology of mammalian basal ganglia
The psychopharmacology of astroglial cells The hippocampus and its response to differential environments Visually-induced seizures Psychopharmacological aspects of an antiepileptic treatment
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LIST OF PREVIOUS REVIEW ARTICLES
J. O. McNAMARA,M. C. BYRNE, R. M. DASHEIFF and J. G. FITZ P. A. V. ANDERSON L. W, HAYNES J. M. KOOLHAAS,T. SCHUURMANand P. R. WIEPKEMA G. N. AKOEV A. A. LOWE VOLUME 16 M,J. DOUGHTYand S. DRYL P. A.M. VAN DONGEN
M, WOLLEMANN J. LMARTINEZ JR., R. A. JENSENand J. L. MCGAUGH J. W. PHILLISand P. H. Wu H. ASANUMA S. T. MASON VOLUME 17 G. B. BAKER,R. T. COOTTS and I. L. MARTIN M. N. GHABRIELand G. ALLT A. G. BROWN P. A. M. VAN DONGEN J. W. PHILLISand P. H. Wu E. EIDELFIERG A, D. GRINNELLand A. A. HERRERA VOLUME 18 K, V. SUDAKOV A. J, ELBERGER C. R. GARDNERand R. J. WALKER W. SCHULTZ G. RONQUISTand A TERI~NT P. A. KOMETIANI,N. G. ALEKSIDZEand E. E. KLEIN F. MATSUMURAand J. MARSHALLCLARK G. GRON J. A. RICHTER and J. R. HOLTMAN,JR VOLUME 19 F. V. DEFEUDIS R. C. A. FREDERICKSONand L. E. GEARY K.-E. ANDERSSONand C. SJOGREN J. M. BIRD R. S. G. JONES
T. O. NEILD and E. ZELCER R. P. VERTES
The kindling model of epilepsy: a review Epithelial conduction: its properties and functions Peptide neuroregulators in invertebrates The organization of intraspecific agonistic behaviour in the rat Catecholamines, acetylcholine and excitability of mechanoreceptors The neural regulation of tongue movements
Control of ciliary activity in paramecium: an analysis of chemosensory transduction in a eukaryotic unicellular organism The central noradrenergic transmission and the locus coeruleus: A review of the data and their implications for neurotransmission and neuromodulation Endogenous opioids and cyclic AMP Attentuation of experimentally-induced amnesia The role of adenosine and its nucleotides in central synaptic transmission Functional role of sensory inputs to the motor cortex Noradrenaline in the brain: progress in theories of behavioural functions
Analysis of amines in the central nervous system by gas chromatography with electron-capture detection Incisures of Schmidt-Lanterman The spinocervical tract The human locus coeruleus in neurology and psychiatry Catecholamines and the sodium pump in excitable cells Conseqaences of spinal cord lesions upon motor function, with special reference to locomotor activity Specificity and plasticity of neuromuscular connections: tong term regulation of motoneuron function
Neuronal mechanisms of leading motivation The functional role of the corpus callosum in the developing visual system: A review The roles of putative neurotransmitters and neuromodulators in annelids and related invertebrates Depletion of dopamine in the striatum as an experimental model of parkinsonism: Direct effects and adaptive mechanisms Cerebrospinal fluid markers of disturbed brain cell metabolism The neurochemical correlates of memory ATP-Utilizing systems in the squid axons: A review on the biochemical aspects of ion-transport Development dynamics of synapses in the vertebrate retina Barbiturates: Their in vivo effects and potential biochemical mechanisms
The link between analgesia and cardiovascular function: Roles for GABA and endogenous opioids Endogenous opioid peptides: Review of physiological, pharmacological and clinical aspects Aspects of the physiology and pharmacology of the bladder and urethra Computerized tomography, atrophy and dementia: A review Tryptamine: A neuromodulator or neurotransmitter in mammalian brain? Noradrenergic neuromuscular transmission with special reference to arterial smooth muscle Brain stem generation of the hippocampal EEG
LIST OF PREVIOUS REVIEW ARTICLES B. S. ScoTT P. A. V. ANDERSONand W. E. SCHWAB S. L. PETERSONand T. E. ALBERTSON W. COLANGELOand D. G. JONES A. CHAPMAN,P. E. KEANE,B. S. MELDRUM,J. SIMIANDand J. C. VERNIERES VOLUME20 E. E. BITTAR R. H. R. FISHMAN,J. J. FEIGENBAUM,J. YANAI and H. L. KLAWANS J. A. WILSONand C. E. PHILLIPS E. KVAMME W. WALZand L. HERTZ T. M. ITIL H. McLENNAN Y. MOCHIZUKI,T. GO, H. OHKUBOand T. MOTOMURA S. HOMMA J. A. DEUTSCH VOLUME21 G. C. PALMER J. J. MCARDLE B. S. SCOTT, L. E. BECKERand T. L. PETIT E. R. JOHN, L. PRICHEP,H. AHN, P. EASTON, J. FRIDMANand H. KAYE S. BRIMIJOIN W. W. LAUTT VOLUME22 W. WILCZYNSKIand R. R. CAPRANICA H.-R. FR1SCHKNECHT C. WINDER and I. KITCHEN G. VIANID1 PRISCO W. H. ROSTENE G. BUZSAKI A. C. PAISLEYand A. J. S. SUMMERLEE T. PHILIPHICKS R. P. VERTES J. C. DE LATORRE I. KITCHEN VOLUME23 K. L. LEENDERS,J. M. GIBBS, R. S. J. FRACKOWIAK,A. A. LAMMERTSMAand T. JONES L. ELFMAN U.-J. P. ZIMMERMANand W. W. SCHLAEPFER K. S.-ROZSA
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Adult neurons in cell culture: Electrophysiological characterization and use in neurobioiogical research Recent advances and model systems in coelenterate neurobiology Neurotransmitter and neuromodulator function in the kindled seizure and state The fetal alcohol syndrome: A review and assessment of the syndrome and its neurological sequelae Mechanism of anticonvulsant action of valproate
The barnacle muscle fibre as a model system for the investigation of the ouabain-insensitive sodium efflux and hormonal actions The relative importance of dopamine and norepinephrine in mediating locomotor activity Pre-motor non-spiking interneurons Ammonia metabolism in the central nervous system Functional interactions between neurons and astrocytes. II. Potassium homeostasis at the cellular level The discovery of antidepressant drugs by computer-analyzed human cerebral bio-electrical potentials (CEEG) Receptors for the excitatory amino acids in the mammalian central nervous system Development of human brainstem auditory evoked potentials and gender differences from infants to young adults Physiology and pharmacology of putative transmitters in lamprey central nervous system Dietary control and the stomach
Effects of psychoactive drugs on cyclic nucleotides in the central nervous system Molecular aspects of the trophic influence of nerve on muscle Neurobiology of Down's syndrome Neurometric evaluation of cognitive dysfunctions and neurological disorders in children Molecular forms of acetylcholinesterase in brain, nerve and muscle: Nature, localization and dynamics Afferent and efferent neural roles in liver function
The auditory system of anuran amphibians Effects of cannabis drugs on social behaviour of laboratory rodents Lead neurotoxicity: A review of the biochemical, neurochemical and drug induced behavioural evidence Hebb synaptic plasticity Neurobiological and neuroendocrine functions of the vasoactive intestinal peptide (VIP) Feed-forward inhibition in the hippocampal formation Relationships between behavioural states and activity of the cerebral cortex The history and development of microiontophoresis in experimental neurobiology Brainstem control of the events of REM sleep Spinal cord injury models The rise and fall of endogenous opioid nomenclature
Positron emission tomography of the brain: new possibilities for the investigation of human cerebral pathophysiology lmmunisation with Torpedo acetylcholine receptor Calcium-activated neutral protease (CANP) in brain and other tissues The pharmacology of molluscan neurons
xiv
LIST OF PREVIOUS REVIEW ARTICLES
M. PALKOVITS J. J. FEIGENBAUMand 3. YANAI D. LEHMANNand W. SKRANDIES M.-C, CALVETand J. CALVET T. YAMAMOTO T. V. GETCHELL, F. MARGOLISand M. L. M. L. GETCHELL VOLUME24 J. O. PICKLES M. A. SIMMONS M. B, ROSENBERG,C. HANSENJR and X. O. BREAKEF1ELD J.-C. DAVID and J.oF. COULON A. KIDMAN G. AUDESIRK R. HARI and E. KAUKORANTA D. YAMAMOTO G. TREDICI, L. TORRI TARELLI,G. GAVALETTI and P. MARMIROLLI VOLUME25 D. H. YORK
P. CANCALON H. BRAAKand E. BRAAK
Z. ELAZARand A. HOBSON H. J. MARKOWITSCHand M. PRITZEL G. SCALABRINO, M. E. FERIOLI and G. LUCCARELLI M. M. SALPETERand R. H. LORING
M. J. DASCOMBE VOLUME26 B. H, BLAND Y. DUNANT J. B. WILLIS P. G. GREEN and I. KITCHEN A. J. S. SUMMERLEE J. A. RIBEIROand A. M. SEBASTIAO P. KASA D. M. ARMSTRONG
Distribution of neuropeptides in the central nervous system: ~,_ review of biochemical mapping studies Normal and abnormal determinants of dopamine and receptor ontogeny in the central nervous system Spatial analysis of evoked potentials in man--a review Computer assisted analysis of HRP labelled and golgi stained purkinje neurons Taste responses of cortical neurons Perireceptor and receptor events in vertebrate olfaction
Recent advances in cochlear physiology The complexity and diversity of synaptic transmission in the prevertebral sympathetic ganglia Molecular genetic approaches to neurologic and psychiatric diseases Octopamine in invertebrates and vertebrates: a review Neurochemical and cognitive aspects of depression Effects of lead exposure on the physiology of neurons Neuromagnetic studies of somatosensory system: principles and examples The operation of the sodium channel in nerve and muscle Ultrastructural organization of lamina VI of the spinal cord of the cat
Somatosensory evoked potentials in man: Differentiation of spinal pathways responsible for conduction from the forelimb vs hindlimb Influence of temperature on various mechanisms associated with neuronal growth and nerve regeneration Golgi preparations as a tool in neuropathology with particular reference to investigations of the human teleneephalic cortex Neuronal excitability control in health and disease: A neurophysiological comparison of REM sleep and epilepsy The neuropathology of amnesia Polyamine biosynthesis in primary tumors of human central nervous system: Review of current knowledge Nicotinic acetytcholine receptors in vertebrate muscle: Properties, distribution and neural control The pharmacology of fever
The physiology and pharmacology of hippocampal formation theta rhythms On the mechanism of acetylcholine release The modelling of neural circuitry Antinociception opioids and the cholinergic system The neural control of luteinizing hormone release Adenosine receptors and calcium: Basis for proposing a third (A3) adenosine receptor The cholinergic systems in brain and spinal cord Supraspinal contributions to the initiation and control of locomotion in the cat
KINDLING MECHANISMS: CURRENT PROGRESS ON AN EXPERIMENTAL EPILEPSY MODEL DAN C. MCINTYRE* and R. J. RACINEt, *Department of Psychology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and tDepartment of Psychology, McMaster University, Hamilton, Ontario L8S 4KI, Canada NEUROBIOLOGY OF AN ANORECTIC DRUG FENFLURAMINE NElL E. ROWLAND and JANIS CARLTON, Department of Psychology and Center for Neurobiological Sciences, University of Florida, Gainesville FL 3261I, USA SOMATOSTATININ THE CENTRAL NERVOUS SYSTEM: PHYSIOLOGYAND PATHOLOGICAL MODIFICATIONS JACQUES EPELBAUM, U. 159 INSERM, Unit6 de Neuroendocrinologie, Centre Paul Broca, 2 ter, rue d'Al6sia, 75014 Paris, France
13
63
THE NEURONAL DETERMINANTSOF RESPIRATORY RHYTHM SUSAN LONG and JAMES DUFFIN, Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
101
SINGLE UNIT ACTIVITY OF Locus COERULEUS NEURONS IN BEHAVING ANIMALS BARRY L. JACOBS, Program in Neuroscience, Department of Psychology, Princeton University, Princeton, NJ 08544, USA
183
STUDIES ON THE OLFACTORY NERVOUS SYSTEMOF THE OLD WORLD MONKEY SADAYUKI F. TAKAGI, Department of Physiology, School of Medicine, Gunma University, Maebashi 371, Japan
195
SPROUTING AND REMODELLING AT THE NERVE-MUSCLE JUNCTION ANTON WERNIG* and ALBERT A. HERRERAt, *Department of Neurophysiology, University of Bonn, Wilhelmstrabe 31, D-5300 Bonn 1, West Germany tNeurobiology Section, Department of Biological Sciences, and Program in Neural, Informational and Behavioral Sciences, University of Southern California, Los Angeles, California 90089-0371, USA
251
FEEDING AND TASTE THOMAS R. SCOTT and GREGORY P. MARK, Department of Psychologyand Institute for Neuroscience, University of Delaware, Newark, DE 19716, USA
293
CARDIOVASCULAR EFFECTS OF ADENOSINE IN MAN, POSSIBLE CLINICAL IMPLICATIONS A. SOLLEVI, Department of Anesthesiology, Karolinska Hospital, and Department of Pharmacology, Karolinska Institutet, Box 60 400, S-104 01 Stockholm, Sweden
319
RESPONSES OF NEURONS IN ISOLATED PREPARATIONSOF THE MAMMALIAN CENTRAL NERVOUS SYSTEM HENRIK JAHNSEN, Institute of Neurophysiology, University of Copenhagen, Blegdamsvej 3c, DK-2200 Copenhagen N, Denmark
351
Related Journals of Interest
Advances in the Biosciences Current Advances in Endocrinology Current Advances in Neuroscience International Journal of Developmental Neuroscience Neurochemistry International Neuropharmacology Neuropsychologia Neuroscience Physiology and Behaviour Progress in Neuro-psychopharmacologyand Biological Psychiatry Psychoneuroendocrinology (flee specimen copy gladly sent on request)
INDEX Acetylcholine, action on hippocampal neurons 366 Acetylcholinesterase, abandoned synaptic gutters in muscle 253 Acromegaly, role of somatostatin 86 Activity, effect of fenfluramine 24 Adaption, locus coeruleus neuron activity 189 Adenosine, cardiovascular effects 319-349 in body fluids and tissues 321 clinical implications 343 exogenous, effects of 330 formation during ischaemia and hypoxia 325 quantitation 320 receptor antagonism 324 uptake inhibition 321 Adipose tissue, reactive hyperemia, adenosine 329 Aging, synaptic remodelling 262, 267, 268 Alzheimer's disease, somatostatin in brain 88 •,/-Aminobutyric acid, role in kindling 6 3/-Aminobutyric acid - - somatostatin colocalisation in brain 69 Amygdala cell response to odors 231 kindling 3, 5 Anaesthesia, myocardial blood flow and metabolism during 335, 344 Angina pectoris, adenosine formation 325 Anorexia, fenfluramine induced 21 Apneusis 103 Appetite suppressant 13-62 Arousal, locus coeruleus neuron activity 187 Asthma, role of adenosine 341 Atrioventricular conduction, role of adenosine 336, 343 Auditory stimuli, locus coeruleus neuron activity 186 Behaviour locus coeruleus neuron activity 185 effect ofsomatostatin 84 Behaviour modification, fenfluramine and weight loss 19 Blood flow cerebral, effect of adenosine 337 myocardial, effect of adenosine 335, 344 skeletal muscle, effect of adenosine 341 Blood pressure, effect of adenosine 344 Body temperature, effect of fenfluramine 38 Botzinger complex respiratory neurons 106, 114 late-peak expiratory neurons 162 Brain, adenosine formation during ischaemia 327 Brain stem, electroresponsive properties of isolated neurons 362 Bursting cell electroresponsive properties 358 kindling 3 CA1 pyramidal cell electroresponsive properties 353 effect of transmitters 366 CA3 pyramidal cell, electroresponsive properties 354 Carbohydrate intake, effect of fenfluramine 30 Carbohydrate metabolism, effect of fenfluramine 37
Carbon dioxide, expiratory cell discharge 156 Cardioplegia, adenosine formation 327 Carotid occlusion, adenosine formation 327 Catecholamines, role in kindling 6 Caudate nucleus retroambigualis 150 Centroposterior area of orbitofrontal cortex electrophysiology 218, 227 olfactory nerve pathways 211 olfactory representation 207 transthalamic olfactory pathway to 209 Cerebellum, electroresponsive properties of isolated neurons 360 Cerebral blood flow, effect of adenosine 337 Cerebrospinal fluid, adenosine in 321,327 Chemoreceptors, interaction with respiratory neurons 119, 134, 155 Cholecystokinin 311 Cholinergic-somatostatinergic innervations in cortex 88 Compensatory feeding behaviour 306 Conditioned taste aversion 304 effect of fenfluramine 31 Coronary graft occlusion, effect of adenosine 343 Coronary steal 335 Corticotropin-releasing hormone, fenfluraminestimulated release 39 Cranial nerves 115,134, 155 taste 294 Deep cerebellar nuclei cells, electroresponsive properties 361 Dementia, somatostatin in brain 88 Development somatostatin-containing neurons 70 synaptic remodelling 262, 267 Diazepam, locus coeruleus neuron activity 190 Diet selection, effect of fenfluramine 20, 30 5,6-Dihydroxytryptamine, fenfluramine anorexia 46 Dipyridamole, effect on adenosine levels in man 323 Disinhibition hypothesis of kindling 5 Dopamine antagonist action of fenfluramine 49 effect on hippocampal neurons 367 Dorsal horn neurons, electroresponsive properties 364 Early-burst inspiratory neurons 142 Energy wasting, effect of fenfluramine 37 Environment, locus coeruleus neuron activity Epilepsy model, kindling mechanisms 1-12 Expiratory neurons 151,162 Fast spiking celt, electroresponsive properties Feeding and taste 293-317 gustatory anatomy of the rodent 294 gustatory involvement in feeding 300 gustatory neural code 296 Fenfluramine behavioural effects acute anorexia 21 conditioned taste aversion 31
189
358
vi
INDEX
diet selection 30 discriminative stimulus properties 32 free feeding and tolerance to weight loss 26 obese rodent model 29 tolerance, cross-tolerance and set point 24 central mechanisms of action brain 5-hydroxytryptamine 40 dopamine 49 5-hydroxytryptamine-depleting lesion 46 5-hydroxytryptamine receptors 44 mechanisms of decreased 5-hydroxytryptamine levels 41 noradrenaline 50 opioids 50 peptides 51 clinical observations 18 metabolism 15 peripheral actions carbohydrate metabolism 37 gastric emptying and intestinal motility 32 gastric inhibition mechanism 34 gastro-intestinal 5-hydroxytryptamine 36 lipid metabolism 38 metabolic rate 37 pituitary-adrenal axis 39 structure 14 Food intake, effect of fenfluramine 20 Frog abandoned synaptic gutters 253 growth and age effects on synaptic remodelling 265 nerve sprouting and synapse formation 258
5-Hydroxytryptamine-depleting lesions, eflect c~i fenfluramine 46 5-Hydroxytryptamine receptors, effect ~-,r fenfluramine 44 Hypercapnia, expiratory cell discharge 156 Hypotension, effect of adenosine 330 Hypothalamic fibres, projection to prefrontal cortex 203 Hypothalamus, somatostatin secretion 71) Hypoxanthine formation during brain ischaemia 328 release from heart during angina pectoris 325 Hypoxia, adenosine formation 325
Gastric distension, taste 308 Gastric emptying, fenfluramine effects 32 Glossypharangeal nerve, taste 308 Glucose modulation of somatostatin release 74 taste 309 Graft occlusion, adenosine effects 343 Granule cells, electroresponsive properties 355 Growth, synaptic remodelling 262, 267 Growth hormone, modulation of somatostatin release 73 Gustatory anatomy of the rodent 294 Gustatory involvement in feeding 300 Gustatory neural code 296
Junctional modelling
Heart adenosine in 321 adenosine formation during ischaemia/hypoxia 325 clinical implications of adenosine 343 metabolism during anaesthesia, effect of adenosine 335 Hippocampus electroresponsive properties of isolated neurons 352 role in kindling 2, 5 effect of transmitters on neurons 365 Hunger, effect of fenfluramine 19 Huntington's disease, somatostatin in brain 87 5-Hydroxytryptamine in brain, effect of fenfluramine 40 effect on CNS neurons 367 gastrointestinal, effect of fenfluramine 36
Immunohistochemistry, somatostatin 66 Inferior olive, electroresponsive properties of neurons 362, 367 lnosine monophosphate, in skeletal muscle during ischaemia 328 Inspiratory neurons early-burst 142 late-peak 107, 126 upper cervical 167 Insulin, taste 309 Intestinal motility, fenfluramine effects 32, 35 Ischaemia, adenosine formation brain 327 heart 325 newborn infants 329 skeletal muscle and adipose tissue 328 Isolated brain preparations 352 252, 262
Kidney, effect of adenosine on function Kindling disinhibition hypothesis 5 epileptic neuron hypothesis 2 synaptic potentiation hypothesis 1 working hypothesis 9
337
Late-peak expiratory neurons 151, 162 Late-peak inspiratory neurons 107, 126 Lateral hypothalamic area cell response to odors 243 olfactory pathways to 236 Lateroposterior area of orbitofrontal cortex electrophysiology 217, 226 neural pathway to 199 olfactory area in 198 olfactory nerve pathways 211 Learning, locus coeruleus neuron activity 189 Limbic lesions, kindling 5 Lipid metabolism, effect of fenfluramine 38 Locus coeruleus neurons electroresponsive properties 363, 367 single unit activity in behaving animals 183-194 Long-term potentiation 2 Lung, effect of adenosine 341 Lung inflation, neuronal determinants 115, 134, 155, 169 Meal patterns, effect of fenfluramine 26
vii
INDEX Medulla, respiratory rhythm generation 101 Metabolic rate, effect of fenfluramine 37 N-Methyl-D-aspartate, effect on CNS neurons 367 Monkey(Macacca irus), olfactory nervous system 195-250 Morphine, locus coeruleus neuron activity 190 Motor endplate disease, synaptic remodelling 274 Multiple innervation 282 Muscle, skeletal adenosine in 321 adenosine effect on blood flow 341 adenosine formation during reactive hyperemia 328 aging 269 multiply innervated 282 synaptic remodelling 252, 265 Myasthenia gravis, synaptic remodelling 274
Neocortex, electroresponsive properties of isolated neurons 356 Neocortex, olfactory area cat 244 dog 242 monkey 198, 205, 214 rabbit 239 rat 246 Neocortex, olfactory nerve pathways 211 Neostriatum, electroresponsive properties of isolated neurons 358 Nerve-muscle junction, sprouting and remodelling 251-291 Neuromuscular diseases, synaptic remodelling 273 Neurons, isolated, electroresponsive properties 351-372 acetyicholine effects 365 brain stem 362 cerebellum 360 dopamine effects 367 hippocampus 352 neocortex 356 neostriatum 358 noradrenaline effects 366 spinal cord 364 thalamus 359 Neuropeptide Y - - somatostatin colocalisation in brain 69 Newborn infants, adenosine formation 329 Noradrenaline effect on hippocampal neurons 366 role in kindling 7 Noradrenergic neurons, single unit recording in behaving animals 183-194 Nucleus accumbens, neuron response to odors 236 Nucleus ambiguus 104, 126 Nucleus retroambigualis respiratory neurons 105 caudal 150 early-burst inspiratory neurons 142 late-peak inspiratory neurons 126 post-inspiratory neurons 146 rostral 126 Nucleus tractus solitarius 104, 107 taste ceils 294, 301,305, 308 Nutrition-toxicity, taste 303
Obesity, fenfluramine
18, 29
Odor behaviour studies 214 electrophysiology 217 Old world monkey, olfactory nervous system 195-250 Olfactory area, neocortex cat 244 dog 242 function of neurons 214 monkey 198, 205 rabbit 239 rat 246 Olfactory behaviour tests 214 Olfactory bulb, neuron response to odors 228 Olfactory nerve pathways, neocortex 211 Olfactory nervous system, monkey 195-250 behavioural studies 214 comparison with lower mammals 239 electrophysiological studies 217 lateral hypothalamic area 234, 236 neocortex 198 olfactory nerve pathways 211 thalamus 205 Opioids effect on CNS neurons 367 role in fenfluramine anorexia 51 Orbitofrontal cortex neuron function 214 olfactory area in 198,207 olfactory nerve pathways 211
Palatability 300 Parkinson's disease, somatostatin in brain 88 Pheochromocytoma surgery, effect of adenosine 334, 344 Pituitary, somatostatin receptors 75 Putuitary adenomas, role of somatostatin 86 Pituitary-adrenal axis, effect of fenfluramine 39 Plasticity of synaptic efficacy 275 Post-inspiratory neurons 146 Platelets, effect of adenosine 342, 344 Prepyriform cortex cell response to odors 231 olfactory pathways 293 Pulmonary stretch receptors 116 Purines, quantitation 320 Purkinje cell, electroresponsive properties 360 Pyriform cortex, burst generating cells 3
Rabbit, olfactory area in neocortex 239 Reactive hyperemia, role of adenosine 328 Rebound excitation, respiratory neurons 130 Remodelling, synaptic 252, 262 Regular spiking cells, electroresponsive properties 357 Renal function, effect of adenosine 337 Respiratory disturbances, newborn, adenosine involvement 330 Respiratory rhythm I01 Botzinger complex neurons 162 nucleus retroambigualis neurons 126 upper cervical respiratory neurons 168 ventrolateral nucleus tractus solitarius neurons 107 Rostral nucleus retroambigualis 126
INDEX
viii Satiety, receptors 308 Seasonal factors in synaptic remodelling 268 Seizure generation 1 Sensory stimuli, locus coeruleus neuron activity 186 Septum, neuron response to odors 235 Sick sinus syndrome, role of adenosine 336, 343 Sinus automaticity, role of adenosine 336, 343 Sleep, effect of fenfluramine 23 Sleep-wake cycle, locus coeruleus neuron activity 185 Smell discrimination, monkey 214 Sodium, consumption of 306 Somatostatin Alzheimer's disease and dementia 88 anatomical distribution 66 biosynthesis 64 coexistence with other neurotransmitters 69 Huntington's disease 87 inactivation in brain 83 mechanisms of action 78 multiple effects 84 pituitary adenomas 86 receptors in brain and pituitary 75 secretion and release 70 Spike-triggered averaging 160 Spinal cord electroresponsive properties of isolated neurons 364 respiratory rhythm generator 106 Sprouting and remodelling at the nerve-muscle junction 251-291 Stomach, effects of fenfluramine 32 Substance P, effect on CNS neurons 367 Synapse formation 258 Synaptic efficacy, plasticity and regulation 275 Synaptic gutters, abandoned 253 Synaptic potentiation hypothesis of kindling 1 Synaptic remodelling 252 effect of growth and age 265 neuromuscular diseases 273 Synaptic transmission, measures of 275
Taste 293-317 dimensions 300 gustatory anatomy of the rodent 294 gustatory neural code 296 plasticity of responses 303 Tetrodotoxin, effect on hippocampal neurons 354, 357 Thalamus cell responses to odors 233 electroresponsive properties of isolated neurons 359 olfactory input to 205 olfactory projection to prefrontal cortex 210 transthalamic olfactory pathway 209 Theophylline, effect on adenosine levels in vascular beds 324 Thermogenesis, diet-induced 38 Thyroid hormones, somatostatin regulation 78 Tolerance to fenfluramine 24 Tongue 295 Toxicity, taste 301 Transmitters, action on electrical membrane properties of central neurons 365
Tachycardias, effect of adenosine
Xylamidine
336, 343
Upper cervical respiratory neurons
167
Vasointestinal peptide, modulation of somatostatin release 72 Ventrolateral nucleus tractus solitarius respiratory neurons 104, 107 afferents 113 functional interrelations 112 location and morphology 107 patterns of activity 107 projections and synaptic connections 121 Visual stimuli, locus coeruleus neuron activity 186 Water intake, effect of fenfluramine 22 Weight loss, fenfluramine 18, 26 45
LIST OF PREVIOUS REVIEW ARTICLES VOLUME 1 R. PORTER G. J. MOGENSONand Y. H. HUANG K. KRISTENSSONand Y. OLSSON V. T. WYNN J. M. SNEDDON G. G. SOMJEN D. M. GUTHRIE, J. R. BANKSand E. SOMERVILLE
Functions of the mammalian cerebral cortex in movement The neurobiology of motivated behavior Diffusion pathways and retrograde axonal transport of protein tracers in peripheral nerves Absolute pitch in humans, its variations and possible connections with other known rhythmic phenomena Blood platelets as a model for monoamine-containing neurons Electrogenesis of sustained potentials Studies on the neural control of the skating reflex, and the origin of its variations in field population of the hemipterous insect
Gerris H. LABORIT J. S. DE BELLEROCHEand H. F. BRADFORD N. N. OSBORNE VOLUME2 J. R. BLOEDEL P. L. and E. G. McGEER G. I. DRUMMONDand Y. MA R. P. PETERSONand Y. P. LOH P. L. JEFFREY and L. AUSTIN G. PEPEU G. B. BIEDERMAN SHIN-ICHI TERASHIMAand R. C. GORIS VOLUME 3 U. PROSKE and R. M. A. RIDGE R. LAVERTY E. T. ROLLS DEFOREST MELLON A. OLIVERIO P. C. VAUGHAN W. J. McBRIDE and J. D. KLINGMAN VOLUME 4 J. W. JACKLETand K. LUKOWIAK P. A. ANNINGS H. KURIYAMA,N. TASHIRO and Y. ITO S. M. KIRPEKAR
G. F. GWILLIAMand R. MILLECCHIA W. P. BURKARD W. VAN DER KLOOT VOLUME 5 F. R. CALARESU,A. S. FAIERS and G. J. MOGENSON I. IZQUIERDO J. D. WOOD F. BAGUET B. YORK and C. A. G. WIERSMA M. F. MARMOR
Gamma-hydroxybutyrate, succinic semialdehyde and sleep The synaptosome: an isolated, working neuronal compartment The analysis of amines and amino acids in micro-quantities of tissue
Cerebellar afferent systems: a review Neurotransmitter synthetic enzymes Metabolism and functions of cyclic AMP in nerve The role of macro-molecules in neuronal function in Aplysia Axoplasmic transport The release of acetylcholine from the brain: an approach to the study of the central cholinergic mechanisms The search for the chemistry of memory: recent trends and the logic of investigation in the role of cholinergic and adrenergic transmitters Electrophysiology of snake infrared receptors
Extrafusal muscle and muscle spindles in reptiles On the roles of dopamine and noradrenaline in animal behaviour The neural basis of brain-stimulation reward Integrative and organizational aspects of synaptic function in molluscs Genetic and biochemical analysis of behavior in mice Muscle membrane Effects of excitation on the metabolism of a simple neuronal system--the mammalian sympathetic ganglion
Neural processes in habituation and sensitization in model systems The usefulness of artificial neural nets as models for the normal and abnormal functioning of the mammalian CNS On the physiological properties of neuromuscular junction and of obliquely striated muscle in the earthworm Factors influencing transmission at adrenergic synapses Barnacle photoreceptors: their physiology and role in the control of behaviour Adenylate cyclase in the central nervous system The timing of the appearance of miniature end-plate potentials
Central neural regulation of heart and blood vessels in mammals The hippocampus and learning The role of -y-aminobutyric acid in the mechanism of seizures Excitation and control of isolated photophores of luminous fishes Visual processing in the Rock Lobster (Crustacea) The membrane of giant molluscan neurons: electrophysiologic properties and the origin of the resting potential ix
LIST OF PREVIOUS REVIEW ARTICLES L. POIRIER,M. FILION, P. LANGLELIER and L. LAROCHELLS J. B. WILLIS T. J. HARA P. M. SELLICKand B. M. JOHNSTONE VOLUME6 W. R. KLEMM H. L. KLAWANSand W. J. WEINER R. R. DRUCKER-COLINand C. W. SPANIS E. EIDELBERG T. GORDON et al. A. R. FREEMAN M. STERIADEand A. A. HOnSON VOLUME7 M. C. WETZELand D. G. SWART N. KLEMM S. E. DYSONand D. G. JONES W. R. KLEMM A. J. SELVERSTON,D. F. RUSSELL,J. P. MILLER and D. G. KING H. L. ATWOOD VOLUME8 A. VAN HARREVELD LARS-G. ELFVlN C. M. LENT JON STORM-MATHISEN M. FILLENZ M. WILLIAMSand R. RODNIGHT
M. A. CORNER S. G. WAXMANand H. A. SWADLOW F. M. ACHEE, S. GABAYand K. F. TIerON D. E. SMITH VOLUME9 A. ANGEL F. V. DEFEUDIS D. G. AMARALand H. M. SINNAMON R. G. CURLESS R. A. LEVY VOLUME l0 A. A. BORBELY R. W. DYKES I. A. SYTINSKY,A. T. SOLDATENKOVand A. L~rraA J. A. DEUTSCH J. L. JOHNSON B. CSlLLIKand E. KNYIHAR
Brain nervous mechanisms involved in the so-called extra pyramidal motor and psychomotor disturbances A review of some of the models of the brain Olfaction in fish Production and role of inner ear fluid
Physiological and behavioural significance of hippocampal rhythmic, slow activity The pharmacology of choreatic movement disorders Is there a sleep transmitter? Possible action of opiates upon synapses Changes in chemosensitivity of skeletal muscles as related to endplate formation Polyfunctional role of glutamic acid in excitatory synaptic transmission Neuronal activity during the sleep-waking cycle
Ensemble characteristics of cat locomotion and its neural control Histochemistry of putative transmitter substances in the insect brain Undernutrition and the developing nervous system Hippocampal EEG and information processing: a special role for theta rhythm The stomatogastric nervous system: structure and function of a small neural network Organization and synaptic physiology of crustacean neuromuscular systems
Pharmacology of the vertebrate retina The ultrastructure of neuronal contacts The retzius cells within the central nervous system of leeches Localization of transmitter candidates in the brain: The hippocampal formation as a model The factors which provide short-term and long-term control of transmitter release Protein phosphorylation in nervous tissue: possible involvement in nervous tissue function and relationship to cyclic nucleotide metabolism Sleep and the beginnings of behaviour in the animal kingdom-studies of ultradian motility cycles in early life The conduction properties of axons in central white matter Some aspects of monoamine oxidase activity in brain The effect of deafferentation on the development of brain and spinal nuclei
Processing of sensory information GABA-receptors in the vertebrate nervous system The locus coeruleus: neurobiology of a central noradrenergic nucleus Development patterns of peripheral nerve myoneural junction and muscle The role of GABA in primary afferent depolarization
Effects of light on sleep and activity rhythms The anatomy and physiology of the somatic sensory cortical regions Neuroehemical basis of the therapeutic effect of 7-aminobutyric acid and its derivatives The stomach in food satiation and the regulation of appetite The excitant amino acids glutamic and aspartic acid as transmitter candidates in the vertebrate central nervous system Biodynamic plasticity in the Rolando substance
LIST OF PREVIOUS REVIEW ARTICLES J. L. S. COBBand V. W. PENTREATH
E.M. LANDAU VOLUME 1 1 Y. KUDO K. KUBA and K. KOKETSU E. HEILBRONN and T. BARTFAI H. MCILWAIN G. BURNSTOCK P. KOMET1ANI,Z. KOMETIANIand D. MIKELADZE K. S. KRISHNA MURTHY Translated by R. WERMAN VOLUME 12 C. D. BARNESand J. C. SCHADT C. H. HOCKMAN, D. BIEGERand A. WEERASURIYA S. REDMAN A. ROUTTENBERG T. RADOJCIC and V. W. PENTREATH E. S. Vizl G. G. YARBROUGH VOLUME 13 P. M. SALTZMANand R. H. ROTH P. C. EMSON A. NISTRI and A. CONSTANTI M. ISRAEL, Y. DUNANT and R. MANARANCHE L. HERTZ K. E. MOORE and S. M. X,VUERTHELE W. A. MACKAY and J. T. MURPHY J. O'KEEFE VOLUME 14 G. A. KERKUT T. SATO G. J. MOGENSON, D. L. JONES and C. Y. YIM C. B. GUNDERSEN n . SHINOZAKI N. MCNAUGHTONand S. T. MASON A. DRAY VOLUME 15 F. A. HENN and S. W. HENS D. G. JONES and B. J. SMITH A. J. WlLKINS, C. D. BINNIE and C. E. DARBY J. PARNAS, L. GRAM and H. FLACHS
Comparison of the morphology of synapses in invertebrate and vertebrate nervous systems: Analysis of the significance of the anatomical differences and interpretation of the morphological specializations Function and structure of the ACh receptor at the muscle end-plate
The pharmacology of the amphibian spinal cord Synaptic events in sympathetic ganglia Muscarinic acetylcholine receptor Synaptic mediators and the structuring of cerebral activity Do some sympathetic neurones synthesize and release both noradrenaline and acetylcholine? 3', Y-AMP-dependent protein kinase and membrane ATPases of the nerve cell Vertebrate fusimotor neurones and their influences on motor behavior Let us build a nervous system (A fragment of an allegedly ancient Hebrew manuscript reputedly found in the Judean desert)
Release of function in the spinal cord Supranuclear pathways of swallowing Junctional mechanisms at group Ia synapses Anatomical localization of phosphoprotein and glycoprotein substracts of memory Invertebrate glia Presynaptic modulation of neurochemical transmission On the neuropharmacology of thyrotropin releasing hormone (TRH)
Role of impulse flow in the short-term regulation of norepinephrine biosynthesis Peptides as neurotransmitter candidates in the mammalian CNS Pharmacological characterization of different types of GABA and glutamate receptors in vertebrates and invertebrates The present status of the vesicular hypothesis Functional interactions between neurones and astrocytes I. Turnover and metabolism of putative amino acid transmitters Regulation of nigrostriatal and tuberoinfundibular-hypophyseal dopaminergic neurons Cerebellar modulation of reflex gain A review of the hippocampal place ceils
Can fibre optic systems drive lower motoneurones? Recent advances in the physiology of taste cells From motivation to action: Functional interface between the limbic system and the motor system The effects of botulinum toxin on the synthesis, storage and release of acetylcholine The pharmacology of the excitatory neuromuscular junction in the crayfish The neuropsyehoiogy and neuropharmacology of the dorsal ascending noradrenergic bundle--A review The physiology and pharmacology of mammalian basal ganglia
The psychopharmacology of astroglial cells The hippocampus and its response to differential environments Visually-induced seizures Psychopharmacological aspects of an antiepileptic treatment
xii
LIST OF PREVIOUS REVIEW ARTICLES
J. O. McNAMARA,M. C. BYRNE, R. M. DASHEIFF and J. G. FITZ P. A. V. ANDERSON L. W, HAYNES J. M. KOOLHAAS,T. SCHUURMANand P. R. WIEPKEMA G. N. AKOEV A. A. LOWE VOLUME 16 M,J. DOUGHTYand S. DRYL P. A.M. VAN DONGEN
M, WOLLEMANN J. LMARTINEZ JR., R. A. JENSENand J. L. MCGAUGH J. W. PHILLISand P. H. Wu H. ASANUMA S. T. MASON VOLUME 17 G. B. BAKER,R. T. COOTTS and I. L. MARTIN M. N. GHABRIELand G. ALLT A. G. BROWN P. A. M. VAN DONGEN J. W. PHILLISand P. H. Wu E. EIDELFIERG A, D. GRINNELLand A. A. HERRERA VOLUME 18 K, V. SUDAKOV A. J, ELBERGER C. R. GARDNERand R. J. WALKER W. SCHULTZ G. RONQUISTand A TERI~NT P. A. KOMETIANI,N. G. ALEKSIDZEand E. E. KLEIN F. MATSUMURAand J. MARSHALLCLARK G. GRON J. A. RICHTER and J. R. HOLTMAN,JR VOLUME 19 F. V. DEFEUDIS R. C. A. FREDERICKSONand L. E. GEARY K.-E. ANDERSSONand C. SJOGREN J. M. BIRD R. S. G. JONES
T. O. NEILD and E. ZELCER R. P. VERTES
The kindling model of epilepsy: a review Epithelial conduction: its properties and functions Peptide neuroregulators in invertebrates The organization of intraspecific agonistic behaviour in the rat Catecholamines, acetylcholine and excitability of mechanoreceptors The neural regulation of tongue movements
Control of ciliary activity in paramecium: an analysis of chemosensory transduction in a eukaryotic unicellular organism The central noradrenergic transmission and the locus coeruleus: A review of the data and their implications for neurotransmission and neuromodulation Endogenous opioids and cyclic AMP Attentuation of experimentally-induced amnesia The role of adenosine and its nucleotides in central synaptic transmission Functional role of sensory inputs to the motor cortex Noradrenaline in the brain: progress in theories of behavioural functions
Analysis of amines in the central nervous system by gas chromatography with electron-capture detection Incisures of Schmidt-Lanterman The spinocervical tract The human locus coeruleus in neurology and psychiatry Catecholamines and the sodium pump in excitable cells Conseqaences of spinal cord lesions upon motor function, with special reference to locomotor activity Specificity and plasticity of neuromuscular connections: tong term regulation of motoneuron function
Neuronal mechanisms of leading motivation The functional role of the corpus callosum in the developing visual system: A review The roles of putative neurotransmitters and neuromodulators in annelids and related invertebrates Depletion of dopamine in the striatum as an experimental model of parkinsonism: Direct effects and adaptive mechanisms Cerebrospinal fluid markers of disturbed brain cell metabolism The neurochemical correlates of memory ATP-Utilizing systems in the squid axons: A review on the biochemical aspects of ion-transport Development dynamics of synapses in the vertebrate retina Barbiturates: Their in vivo effects and potential biochemical mechanisms
The link between analgesia and cardiovascular function: Roles for GABA and endogenous opioids Endogenous opioid peptides: Review of physiological, pharmacological and clinical aspects Aspects of the physiology and pharmacology of the bladder and urethra Computerized tomography, atrophy and dementia: A review Tryptamine: A neuromodulator or neurotransmitter in mammalian brain? Noradrenergic neuromuscular transmission with special reference to arterial smooth muscle Brain stem generation of the hippocampal EEG
LIST OF PREVIOUS REVIEW ARTICLES B. S. ScoTT P. A. V. ANDERSONand W. E. SCHWAB S. L. PETERSONand T. E. ALBERTSON W. COLANGELOand D. G. JONES A. CHAPMAN,P. E. KEANE,B. S. MELDRUM,J. SIMIANDand J. C. VERNIERES VOLUME20 E. E. BITTAR R. H. R. FISHMAN,J. J. FEIGENBAUM,J. YANAI and H. L. KLAWANS J. A. WILSONand C. E. PHILLIPS E. KVAMME W. WALZand L. HERTZ T. M. ITIL H. McLENNAN Y. MOCHIZUKI,T. GO, H. OHKUBOand T. MOTOMURA S. HOMMA J. A. DEUTSCH VOLUME21 G. C. PALMER J. J. MCARDLE B. S. SCOTT, L. E. BECKERand T. L. PETIT E. R. JOHN, L. PRICHEP,H. AHN, P. EASTON, J. FRIDMANand H. KAYE S. BRIMIJOIN W. W. LAUTT VOLUME22 W. WILCZYNSKIand R. R. CAPRANICA H.-R. FR1SCHKNECHT C. WINDER and I. KITCHEN G. VIANID1 PRISCO W. H. ROSTENE G. BUZSAKI A. C. PAISLEYand A. J. S. SUMMERLEE T. PHILIPHICKS R. P. VERTES J. C. DE LATORRE I. KITCHEN VOLUME23 K. L. LEENDERS,J. M. GIBBS, R. S. J. FRACKOWIAK,A. A. LAMMERTSMAand T. JONES L. ELFMAN U.-J. P. ZIMMERMANand W. W. SCHLAEPFER K. S.-ROZSA
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Adult neurons in cell culture: Electrophysiological characterization and use in neurobioiogical research Recent advances and model systems in coelenterate neurobiology Neurotransmitter and neuromodulator function in the kindled seizure and state The fetal alcohol syndrome: A review and assessment of the syndrome and its neurological sequelae Mechanism of anticonvulsant action of valproate
The barnacle muscle fibre as a model system for the investigation of the ouabain-insensitive sodium efflux and hormonal actions The relative importance of dopamine and norepinephrine in mediating locomotor activity Pre-motor non-spiking interneurons Ammonia metabolism in the central nervous system Functional interactions between neurons and astrocytes. II. Potassium homeostasis at the cellular level The discovery of antidepressant drugs by computer-analyzed human cerebral bio-electrical potentials (CEEG) Receptors for the excitatory amino acids in the mammalian central nervous system Development of human brainstem auditory evoked potentials and gender differences from infants to young adults Physiology and pharmacology of putative transmitters in lamprey central nervous system Dietary control and the stomach
Effects of psychoactive drugs on cyclic nucleotides in the central nervous system Molecular aspects of the trophic influence of nerve on muscle Neurobiology of Down's syndrome Neurometric evaluation of cognitive dysfunctions and neurological disorders in children Molecular forms of acetylcholinesterase in brain, nerve and muscle: Nature, localization and dynamics Afferent and efferent neural roles in liver function
The auditory system of anuran amphibians Effects of cannabis drugs on social behaviour of laboratory rodents Lead neurotoxicity: A review of the biochemical, neurochemical and drug induced behavioural evidence Hebb synaptic plasticity Neurobiological and neuroendocrine functions of the vasoactive intestinal peptide (VIP) Feed-forward inhibition in the hippocampal formation Relationships between behavioural states and activity of the cerebral cortex The history and development of microiontophoresis in experimental neurobiology Brainstem control of the events of REM sleep Spinal cord injury models The rise and fall of endogenous opioid nomenclature
Positron emission tomography of the brain: new possibilities for the investigation of human cerebral pathophysiology lmmunisation with Torpedo acetylcholine receptor Calcium-activated neutral protease (CANP) in brain and other tissues The pharmacology of molluscan neurons
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LIST OF PREVIOUS REVIEW ARTICLES
M. PALKOVITS J. J. FEIGENBAUMand 3. YANAI D. LEHMANNand W. SKRANDIES M.-C, CALVETand J. CALVET T. YAMAMOTO T. V. GETCHELL, F. MARGOLISand M. L. M. L. GETCHELL VOLUME24 J. O. PICKLES M. A. SIMMONS M. B, ROSENBERG,C. HANSENJR and X. O. BREAKEF1ELD J.-C. DAVID and J.oF. COULON A. KIDMAN G. AUDESIRK R. HARI and E. KAUKORANTA D. YAMAMOTO G. TREDICI, L. TORRI TARELLI,G. GAVALETTI and P. MARMIROLLI VOLUME25 D. H. YORK
P. CANCALON H. BRAAKand E. BRAAK
Z. ELAZARand A. HOBSON H. J. MARKOWITSCHand M. PRITZEL G. SCALABRINO, M. E. FERIOLI and G. LUCCARELLI M. M. SALPETERand R. H. LORING
M. J. DASCOMBE VOLUME26 B. H, BLAND Y. DUNANT J. B. WILLIS P. G. GREEN and I. KITCHEN A. J. S. SUMMERLEE J. A. RIBEIROand A. M. SEBASTIAO P. KASA D. M. ARMSTRONG
Distribution of neuropeptides in the central nervous system: ~,_ review of biochemical mapping studies Normal and abnormal determinants of dopamine and receptor ontogeny in the central nervous system Spatial analysis of evoked potentials in man--a review Computer assisted analysis of HRP labelled and golgi stained purkinje neurons Taste responses of cortical neurons Perireceptor and receptor events in vertebrate olfaction
Recent advances in cochlear physiology The complexity and diversity of synaptic transmission in the prevertebral sympathetic ganglia Molecular genetic approaches to neurologic and psychiatric diseases Octopamine in invertebrates and vertebrates: a review Neurochemical and cognitive aspects of depression Effects of lead exposure on the physiology of neurons Neuromagnetic studies of somatosensory system: principles and examples The operation of the sodium channel in nerve and muscle Ultrastructural organization of lamina VI of the spinal cord of the cat
Somatosensory evoked potentials in man: Differentiation of spinal pathways responsible for conduction from the forelimb vs hindlimb Influence of temperature on various mechanisms associated with neuronal growth and nerve regeneration Golgi preparations as a tool in neuropathology with particular reference to investigations of the human teleneephalic cortex Neuronal excitability control in health and disease: A neurophysiological comparison of REM sleep and epilepsy The neuropathology of amnesia Polyamine biosynthesis in primary tumors of human central nervous system: Review of current knowledge Nicotinic acetytcholine receptors in vertebrate muscle: Properties, distribution and neural control The pharmacology of fever
The physiology and pharmacology of hippocampal formation theta rhythms On the mechanism of acetylcholine release The modelling of neural circuitry Antinociception opioids and the cholinergic system The neural control of luteinizing hormone release Adenosine receptors and calcium: Basis for proposing a third (A3) adenosine receptor The cholinergic systems in brain and spinal cord Supraspinal contributions to the initiation and control of locomotion in the cat