Contents of volume 182 and index to volume 18

uman j?-Tubulin

~~h~~~a~zee

j

Multigene

Evolution of inucleotides . .

Fatnily

Each

the Primate ,8-Globiln and in Shore Repeated

W. and Varmus, ~~~~o~~~~~ rnelanogaster. utagenic

IMine

between arms of quences

trachromosomaI

Iements, I? Eleme Variation in Cultured

Specificit,y

Gene Sequences

of Ultraviolet

Cells and Light

.

.

.

.

he, g 1acP Mutations B ~y~a~~~, r an Alternate

H., qa-2 Genes of ~~~ros~Qra

~~de~endent~y for Transposition

Genetic .

65

Control

of Chr~~at~~ . .

of Cointegrate . . Structure . .

F. J., Miller, J. P. and

ry, M., Nucleosome the Transcribed . . .

The Structure volution

of the Cubic

.

Phases

of the Cytochrome

5’ to the p-x and . I .

e in Catabolite . ~

Di .

of .

Globin

.

.

s Tr~~~~ri~t~on Genes in . .

.

.

esmame

tra) Virus

and its Functional

Pmplications 111

.

rientation of t Unit of Hneer

Data.

D9 Structure Genome

and is urine .

.

t~offilament

Beetle

1

c: amily

Range

asma

I

Analogs of Cyefic

Defined Confo mically ) but do not Stimulate limited to ~rytbr~~~~~c~~a Cells

C., Construction

:

M., Tn5 Transposes Model

31 45

ryos

Ear

of the ,

183

asaki,

H. and Ohta,

Kew

alsh,

T. P., Trueblood,

Elements

Chain

and Distance Geometry for t . . .

.

.

.

.

.

Williamson, Pnbibitor istance

Geometry

of Proteinaw ‘esonance and .

.

Appendix:

.

amphuis,

I.

., Drenth,

.

J. an

Folding of C. and Fontana, of the Minimum Size of a Clagboxyl-terminal Native-like Structure

*, Vita,

Identification into a Stable

Letters to the Editor Riisch, P. and Gross, agnetie

Levine,

K.-

Resonance Muscle

Goldman,

A.,

Muconate

Ollis,

D. LB

Lactonising

Announcements.

D3 Structure . .

.

gai,

Enzyme

.-‘I,.

and

of Short

Steitz,

at 6.5 A Resolution

.

33’1

34 1 Filament,s

Crystal .

from

Structure

.

of

.

umber Pittet,

A.-C.

Closely

Cross,

and

T. A. and

Resonance.

Liu,

Schibler,

Linked

Opella,

Residues

A. Y. C., Michels, Surface

U.,

Mouse

Ipha-amylase

.

Glycoprotein

Loci, .

S.

40 to 45’bf

P. A. M.,

Amy-B” ~

Protein Structure by Solid State Bacteriophage fd Coat Protein

Ber

Genes Expresse

ards, A. and Borst, Early

in Infection

38 7

in the ’

Thick A., .

295 311

~bermo~ysi~ ragments Fragment that Car, FoL .

Assignment of Aromatic Spin Systems Spectrum of A enylate Kinase

R. J. C. an

Limulus

.

roeeases. Comparative Studies pain and Actinidin, and on Amino Acid , and Stem Rromelain

Based on the High-resolution Sequence Information for Cathepsins

alzoppo,

of

C.

eisler, E., Light

Resonance Solution.

Gmtrol

and

Amy-Y,

Nuclear

are

agnetic

a3 Trypanosome

Variant /

as, A., Kolter, R., ~eq~~rern~~ts

for Transcription

inkler, M. E. an Pausing

tlarz, D. and Busby, S., Point

utations .

coli gaZE Gene

e Escherichia

yg C., Analysis ron

in the Trypt

that .

. Affect .

of t ~

Translation . .

41

T., Heuyerjans, J., Jo~~bloed, R. J. H. and Schoenrnakers, J. G. .) Characterizatio y-Crystallin

Gene Family

Leonard,

and its Expression

Lens

in the

K.,

Three-dimensional Structure ended Tails of Bacteriophage T4 . -9 Craig, uscle

R. an

eonard,

.

s9Arthrin: .

.

.

j

rozen--

of Unstaine . .

A new A&in-like . , .

489

.

431 Protein

in .

.

443

structure 30a at 3-Q

a9 Richardson,

J. S. and

ion Studies of Acyl

Carrier Prot

fbme, Therm;1 Inducibility CQS Cells

455

esolution

C., Preliminary ia coli

-ray

and Tissi&res, A., n’ucleot,ide Sequ ces Responsible for the of the Drosophila Small Neat-shock rotein Genes in Monkey . . . I . . of an Alphoi;?“) N., Isolatjion and Characterization e IIuman U Chromosome . . D9Sequences Essent’ial for IS50 . n of Transcription . . ,

and Calendar, R., Location

of th

4 Origin

acteriophage

.

S., Sense Codons are Found in Specific Contexts

.

Moreno-Lopez, J. an ettersson, U., Messenger 11of I3ovine Papil!oma Virus Type I an, F. and James, M. N. xtension of Protein cw~Irat’irm

Structure

efinement.

Ele&ron &eplom~/ws

Density Calculations as an griseus Protease A at l-5 B . . 9 R., Inhibition

Bacteriophage

T7

.

.

.

herd, J. C. W., Pripfl, T. and nlmonrlla

Species. Purificat~ion endon Collagen

of the

555

Actin

binding, light chain dependent effects on the S-l/S-2 swivel in myosin, 271 and papain Actinidin structures, amino acid sequence information for cathepsins B and H and stem bromelain; comparative studies of thiol proteases, 317 Acto-subfragment-l ATPase co-operative response to increasing calcium concentrations, and the removal of tropomyosin over?ap, 265 Acyl carrier protein from Eschwiehia coli. preliminary X-ray diffraction studies. 467 Adenylate kinase, assignment of the aromatic spin systems in the ‘H n.m.r. spectrum, 341 AnoLA, H. (see also ISTPivLuxD, A.), 541 ALBERTINI, A. (see also MILLER, J. H.), 65 Alpha-amylase Amy-2 gene family of mouse strain CE/J contains duplicated 5’ termini, I Alpha-amylase loci, Amy-i’ and Amy-2”, mouse, are closely linked, 359 Alp&d centromeric repeat family from the human Y chromosome, isoiation and characterization, 477 Amy-la and Amy-2a, mouse alpha-amylase loci. are closely linked, 359 Array-2 alpha-amylase gene family of mouse strain CE/J contain duplicated 5’ termini, 1 ANDERSON,

D. (see

also

SOWADWI,J.

M.),

617

N., Ua~ro,

.rEARNPIPATB(uL. K.. MuTA,

A., TAT~UMI, & QSHIMA,

N.,

SAKURAI,

T.,

Y., Molecular and of yeast plasmid pSR1, 191 and polymorphism of bipolar isopranyi T.

P.K.,

STUDIER,

functional organization Archaebacteria, structure ether lipids, 133 arl mutants of Escheriehia co&, apparent alteration in properties, 611 Aromatic spin systems. assignment in the ‘H n.m.r. spectrum of adenylate kmase. 341 Arthrin: a new actin-iike protein in insect flight muscle, 443 ASCENZI. P., BR~NORI, M. & CIACOMETTI, G.M., Thermodynamics of t.he reaction of ferric myoglobin from Aplysia Zimacina with aside and fluoride. Dependence of enthalpy changes on pN, 607 Autoregulation by large T antigen, and SV40 early promoter mutations, 229 AYME, A., SOUTBGATE~ R. & TISSI~~RES, A., Nucleotide sequences responsible for the thermal inducibihty of the Drosophda small heat-shock protein genes in monkey CC@ ceils, 469 Aside and fluoride, thermodynamics of the reaction with ferric myoglobin from igplysia limacinu; dependence of enthalpy changes on pH, 607

Bacteriophage Ed coat protein, residues 40 to 45; protein structure by solid state n.m.r.: 367 Bacteriophage P4 DNA replication. Location of the P4 origin, 519 Bacteriophage P4 DNA replication in vitro. Partial purification of the P4 a gene product, 509 Raeteriophage T4 pre-replieative transcription, new control elements, 249 Bacteriophage T4, three-dimensional structure of unstained, frozen-hydrated extended tails, 431 Sacterio+age T7, inhibition of the type I restrictionmodrfication enzymes EwK and EcoK by the gene 0.3 protein, 567 &KER, E. N. (see also %(AMPHUIS, I. G.), 317

F. w.,

KAMILTOIS,

D. L.

&,

Inhibition of the type I restriction-modification enzymes EcoB and EcoK by the gene 0.3 protein of bacteriophage T7, 567 BARIK,S.,UHATTACHARYA,P.& DA?.. A., Autogenousregulation of transcription termination factor Rho, 495 BAI:I. J. A. & GILPS, N. H., Genetic control of ehromatin structure 5’ to the q-r and qa-2 genes of Xewospora. 79 BELL. J. (see aiso BULLARD, B.), 443 BERG,

D. E. (see also

SASAKAWA:

C.),4&7

Lru, A. Y. C.), 3X3 /?z subunit, of Escnerichia ooli tryptophan synthase, kinetics and importance of the dimerization step in the folding pathway, 597 BHATTACHARYA, I?. (see also BARPK. S.); 495 &CKLE; T. A. (see alsoNAa~E~~a,!J.),579 Black beetle virus (see also Virus), 183 BLOND, S. & GOLDBERG, &I. E., Kinetics and importance of the dimerization step in the folding pathway of the jz subunit of Escherichia coli tryptopban synthase, 597 BERNARDS,A.(~~~

BODARY,

also

S.,CR~SSI,G.,HAGEN~~~~ILE,

0. & WELLAUER,P.

Members of the Amy-2 alpha-amylase gene family strain CE/J contain duplicated 5’ termini, I B~ELENS,R.

(see

also

KAPTEIN,

P. (see also Lx, Bovine papilloma virus region : 541 BRCNORI, BUCKLE,

R.),

M. (see also ASCENZI, 17. J. (see also WOLFE,

P.),

K.,

of mouse

179

A. U. C.), 383 type I, mRNAs

BORST.

Antiparallel orientation of the two double-stranded coiled-coils in the tetramesic protofi!ament unit of intermediate filaments. 173 A&sin. limacina ferric myoglobin, thermodynamics of the reaction with aside and fluoride; dependence of enthalpy changes on pH. 667 ARAKI,

BAXDYOPhDHYAY, UI:AN, R.,

from

the transforming

607

J.), 477 Bull seminal plasma proteinase inhibit’or IIA, solution conformation by ‘H n.m.r’. and distance geomet,ry, 295 BWLLARD. B., BELL: J., CRAIG, R. & LEOEUED, K., Arthrin: a new actin-like protein in insect flight muscle, 443 Bussr. S. (see also DREYFGS, III.). 411 Calcium concentrations, increasing, and the response of the actosubfragment-l ATPase; and the removai of tropornyosin overlap, 265 CALENDAR, R. (see also KREVOLIN,~%. D.). 589, 519 CANNISTRARO, V. J. & KENNELL, D., The 5’ ends of Escherichia coli lac mEWA, 241 Carboxyl-terminal fragment, and the minimum size that can fold into a stable native-like structure: folding of thermolysin fragments, 331 CARLB.~.

P. (see also

SASAKAWA,C.),~~~

Cataboiite gene activator protein (CAP). biochemically defined conformational change is elicited by analogs of CAMP that do not stimulate binding to DNA, 93 Cathepsins B and H and stem bromelain, amino acid sequence information? and structures of papain and actinidin; comparative studies of thjol proteases, 317 (:NEBLOUNE,

I'.

(see also

SAVATIER,

P.),

21

Chimpanzee and man, high rate of variation in CpG dinucleotides and in short repeated sequences; evolution of the primate b-globin gene region, 21 CHOTNIA, 6. & LESK, A. M., Helix movements and the reconstruction of the haem pocket during the evolution of the cytochrome (: family, 151 Chromatin structure. genetic control. and the qa-.r and q-2 genes of Neurospora, 79 Chromosome. Y, human, isolation and characterization of an aiphoid centromeric repeat family, 477 ~IARAXELLA. M. (See alSO PULITZER. J. F.), 249 Coat protein. bacteriophage fd, residues 40 to 45: protein structure by solid state n.m.r., 367 Codons. sense, are found in specific cont,exts, 529 COHEN. R. B. & SHEFFERY, RI., Nucleosome disruption precedes transcription and is largely limited to the transcribed domain of globin genes in murine erythroieukemia sells, 109

Coiled-coils, double-stranded, in the tetramerir protofilament unit of intermediate filaments; antiparallel orientation, I73 Cointegrate resolution. and independent Tn5 transposition. Evidence for an alternative model for transposition, 69 Colicin E3 and its immunity genes, 217 Collagen, tendon, stress-induced molecular rearrangement, 589 COLOMBO, M. (see dso PULITZER. J. F.), 249 COMB~PINE, C. (see also MILLER, J. II.), 65 Conformation in solution of proteinase inhibitor IIA from bull seminal plasma by ‘II n.m.r. and distance geometry, 295 Conformational change, biochemically defined, in catabolite gene activator protein (CAP) is elicited by analogs of cAMP that do not stimulate binding to DNA, 91 Conformations of proteins in solution, an evaluation of the combined use of n.m.r. and distance geometry for their determination, 281 Control elements, new; of bacteriophage T4 pre-replieative transcription, 249 Co-operative response to increasing calcium concentrations of the acto-subfragmentATPase, and the removal of tropomyosin overlap, 265 copia-like transposable elements, extrachromosomal DNA forms in Drosophila melanogaster; variation in cultured cells and embryos, 31 COS monkey cells, nucleotide sequences responsible for the thermal

inducibility

of

the

Drosophila

small

heat-shock

protein genes, 469 (>OWAN. N. J. (see also LEWIS, S. A.), II CpG dinucleotides show high rate of variation between man and chimpanzee; evolution of the primate p-globin gene region, 21 CRAIG, I. W. (see also WOLFE, J.), 477 CRAIG, B. (see also BULLARIP, B.), 443 CROSS, T. A. & OPELLA, S. J., Protein structure by solid state nuclear magnetic resonance. Residues 46 to 45 of bacteriophage fd coat protein. 367 Crystal structure of muconate lactonizing enzyme at 6.5 A resolution, 353 y-Crystallin gene family, rat, characterization and expression in the eye lens, 419 Crystallization studies of CAMP-dependent protein kinase. Crystals of catalytic subunits diffract to 3.5 A resolution, 617 Cyclic AMP analogs that elicit the biochemically defined conformational change in catabolite gene activator protein (CAP) but do not stimulate binding to DNA, 91 CAMP-dependent protein kinase, crystallization studies; mythsis of catalytic subunit diffract to 3.5 A resolution, 61’7 Cytochrome c family, helix movements and the reconstruction of the haem pocket during evolution, 151 Cytochrome cs5 1, calculation of the pII dependence of the redox potential; electrostatic interactions in globular proteins. 613 DAHLBERC, A. E. (see also STARK, M. J. EL.). 205 DALZOPPQ, D., VITA, C. & FONTANA, A.. Folding of thermolysin fragments. Identification of the minimum size of a carboxylterminal fragment tbat can fold into a stable native-like structure, 331 DARLING. S. M. (see also WOLFE, J.), 477 DAS, A. (see also BARIK, S.), 495 DAS, A. (see also FISHER. R. F.), 397 DAM, G. C. & SALzXax, N. P., Simian virus 40 early promoter mutations that affect promoter function and autoregulation by large T antigen, 229 DASGUPTA, R. (see also DASMAHAPATRA. B.). 183 DASMAHAPATRA,U.,DASGUPTA, R.,&osH, A. & KAESBERC,P., Structure of the black beetle virus genome and its functional implications, 183 I)E ROSA, M. (see also CULIK, A.), 131 DEN DUNNEN, J. T. (see also MOORMANX, R. ?J. M.), 419 DNA binding is not stimulated by analogs of CAMP that elicit the biochemically defined conformational change in catabolite gene activator protein (CAP), 91 DNA forms, extrachromosomal, of copia-like transposable elements, F elements and middle repetitive DNA sequences in Drosophila melanogaster. Variation in cultured cells and embryos, 31

DNA.

P4. replication in ?,itro. Partial purificstioi; of %he P4 a gene product, 509 DNA recognition squences. and purification: t\vo type 1 restriction enzymes from SaZmoneZZcr species. d79 DNA replication, P4: location of the P4 origin. 519 Dimerization step in the folding pathway of the fiz subunit of Eschwirhia di tryptophan synt,hase, kinetics and importance, 597 Distance geometry and n.m.r., an evaiuation of their ~vmbinecl use for the determination of protein ronformations in solution, 2X1 Distance geometry and n.m.r.. and the solution conformation of proteinase inhibitor IIA from bull seminal plasma. 295 DRENTX, J. (see also KAImr7:rs, I. G.), 317 RnYFUs, M., K~TLARZ, D. S: BvssY. S.. Point mutations that affect translation initiation in the Eschericl/,in co/i q&F: gem. 411 Drosophila melanogaster, extrachromosomal DNA forms of copialike transposable elements, F elements and middle repetitive DNA sequences; variation in culture ce?ls and embryos. 31 Bosophila smali heat-shock protein genes in monkey CWS cells. nucleotide sequences responsible for’ the thermal inducibility. 469 EBRIGHT, R. Ii., LE CRIOI~, S. F. J., MTLLIER, J. I’. & RKAK~W, 9. S.. Analogs of cyclic AMP that elicit the biochrmicall~ defined conformational change in catabolite gene activator protein (CAP) but do not stimulate binding to DSA, 91 E’coB and EcoK restriction-modification enzymes. inhibition by the gene 0.3 protein of bacteriophage T7, 567 Electron density calculations as an extension of protriii structure refinement,. Strrptomyces griseus prot,ease A at 1.5 -X resolution, 555 Electrostatic interactions in globular proteins: calculation of Ihe pH dependence of the redox potential of cytochrornr c55i, 613 Enthalpy changes. dependence of pii; tbermotlynamics of the reaction of ferric myoglobin from ApZvsi‘a iiw~acino with azide and fluoride, 607 ERICKSON, R. P. (see also Woman, J.), 477 &~ST. S. R. (see also PAulis. E. Xl.). 465 Erythroleukemia cells, murinr, nucleosome disruption precedes transcription and is largely limited to the transrribetl domain of globin genes, 109 EscheGhin coli, apparent alteration in properties of nrl mutants. 611 GschaGchia co/i gaZE gene, point mutatjions that afkt translation initiation, 411 Escherichia coli Zac mRNA. the 5’ ends, 241 Escherichia coli, preliminiary X-ray diffraction studies of acyl carrier protein, 467 Escherichia c:oZi rRNA operon, a mutation that, blocks the product,ion of precursor 23 S rK?JA by RNase III in viw and in n&o, 205 Esch~r%ch%~ coli tryptophan synthase, kinetics an.d irnportanc~ of the dimerization step in the folding pathway of the jz subunit. 597 EVANS. 1%. (see also WALSH. T. P.), 265 Evolution of the cytocbrome c family, helix movemerlts and the reconstruction of the harm pocket. 151 Evolution of the primate /-globin gene region. High rat,e of variation in CpG dinucleotides and in short repeated sequences between man and chimpanzee. Xl Eye lens, and expression of the rat y-crystailin gene hrnily. 419 F

elements.

extrachromosomal DNA forms in i)~~.wphllu variation in cultured cells and embryos. 31 FAURE. C. (see also SAVATIEII. P.). %I fd (see also Bacteriophage), 367 Ferric myoglobin from ApZysia Zirnacina, thermodynamics of the reaction with azide and fluoride: dependence of enthalpy changes on PH. 607 Filaments. intermediate, antiparallel orientation of the two double-stranded coiled-coils in the tetrameric protofilament unit, 173 Filaments, thick, short, from Limulus muscle, structure, 347 mdnnogaste~;

IXDEX

FISHER.

R. F.: DAS, A., UANOSKY, C., Analysis

KOLTER,

R.,

WINKLER,

M. E.

FOLKHARD,

FomEY, MONTANA,

W.

(see

also

MOSLEH,

E.),

589

1,. S. (see also PaRus, A. (see

ah

XI.), 529 DALZOPPO. D.), 331

ynlE

gene, Escherichia translation initiation, GAMBACQRTA, A. (see also

co&, 411

point

GULIK,

A.),

mutations

that

affect

I31

E. & WEBER, K., Antiparallel orientation of the two double-stranded coiled-coils in the tetrameric protofilament unit of intermediate filaments, 173 Gene, ECscherichia coEi g&E, anti point mutations that affect translation initiation, 411 Gene family, alpha-amylase, Amy-Z, of mouse strain CE/J, contains duplicat.ed 5’ termini, 1 Gene family, p-tubulin, human, three expressed sequences each define a distinct isotype, 11 Gene family, y-crystailin, rat, characterization and expression in the eye lens, 419 Gene product, P4 a. partial purification; the replication of bacteriophage P4 DNA in z&o, 509 Gene 0.d protein of bacteriophage T7, inhibition of the type I restriction-modification enzymes EcoB and EeoK, 567 Gene region, P-globin, evolution in primates. High rate of variation in CpG dinucleotides and in short repeated sequences between man and chimpanzee, 21 Genes, globin, nucleosome disruption precedes transcription and is largely limited to the transcribed domain, in murine erythroleukemia cells, 109 Genes. immunity, of colicin E3, 217 Genes, small heat-shock protein, Droso$zila, in monkey COS cells, nucleotide sequences responsible for t.he thermal inducibility, 469 Genes, trypanosome variant surface glycoprotein. expressed early in infection, 383 Genetic control of chromatin structure 5’ to the qu-z and qa-2 genes of Nruroaporn, 79 Genome structure of black beetle virus, and its functional implications, I$3 GIiOSH; A. (see also D.~~~WAHAPATRA, U.), 183 GTACOMETTI. G. M. (see also ASCENZI, P.), 607 GILES, ?J. H. (see ah huixI j. A.), 79 GILMARTIA, M. E. (see aiso LEWIS, S. A.), 11 Globin genes: nucleosome disruption precedes transcription and is largely limited to the transcribed domain, in murine erythroleukemia celis, IO9 &Globin gene region evolution in primates. High rate of variation in CpG dinucleotides and in short repeated sequences between man and chimpanzee, 21 Globular proteins, electrostatic interactions; calculation of the pH dependence of the redox potential of cytochrome cssl, 683 Glycerol dialkyi nonitol tetraether, structure of the phase P, 146 C~LDREILG, M. E. (see aiso BLOND; S.), 597 GOLDMAN, A., &Us, D. L., NcAI, K.-E. & STEITZ, T. A., Crystal structure of muconate lactonising enzyme at &5A resolution, 353 GO~DFELLOW, P. X. (see also WOLFE, J.), 477 GOURSE, B. I,. (see also STARK, M. J. R.), 205 QQUY, M. (see also SAVATIER, P.), 21 CROSS, K.-H. (see also R&err, I?.), 341 GEISLER.

GRossr,G. GULIK:

N.,

KXIJE’MANN,

(see also B~DARY, S.), 1 A., LCZZATI, V., DE Rosa,

M.

$

GAMBACORTA,

Structure and polymorphism of lipids from archaebacteria, 131

Br.

of the requirements for transcription pausing in the tryptophan operon, 397 5’ ends of Escherichia coli lac mRNA, 241 5’ termini, dupiicated, are contained in members of the Amy-2 alpha-amylase gene family of mouse strair, CE/J, 1 Fluoride and azide, thermodynamics of the reaction with ferric myoglobin from Aplysio limaeina; dependence of enthalpy changes on pII, BO? Folding pathway of the p2 subunit of Escheriehia coli tryptophan syntbase, kinetics and importance of the dimerization step, 597 Folding of thermolysin fragments. Identification of the minimum size of a carboxyi-terminal fragment that can fold into a stable native-hke structure, 331

A.,

HACBERT,

Haem

bipolar

isopranyl

PARKS. E H.), 455 reconstruction, and helix movements, of the cytochrome c family, 151

ether

M. L. (see also

pocket evolution

HAGENB~~~NLE, 0. (see also BODARY, 8.); 1 HALL. J. L. (see also LEWIS, $. A.), I1 HAMZTOK, D. L. (see also BANDY~FADH~.~Y, HAML~N. R. (see also PARKS, E. H.), 455 NAVEL, T. F. & W~T~RICH, K., An evaluation

during

P. K.).

the

567

of the combined use of nuclear magnetic resonance and distance geometry for the determination of protein conformations in solution, 281

HAVEI,. HAYS,

T

P. (see

HOFER.

M. (see

also

WILLIANISON,

T. I?.),

29%

J. B. & HORBA, B. E., Apparent alteration in properties of arl mutants of Escherichia coli, 61 I Headpiece, Zac repressor, structure from n.m.r. data, 179 Heat-shock protein genes, small, Drosophila, in monkey CGS cells, nucleotide sequences responsible for the thermal inducibility, 469 Helix movements and the reconstruction of the haem pocket during the evolution of the cytochrome c family. 151 HEUYERJANS, J. (see also M~~RRIANN; R. 9. M.), 419 Histidine decarboxyiase from LactobaciEZus 3&z. structure at 3.0 A resolution, 455 also

MILLER,

J. H.),

65

Muman p-tubulin multigene family, three expressed each define a distinct isotype, 11 Human P chromosome, isolation and characterization a,Lphoid centromeric repeat family, 477

sequences of an

Immunity genes of colicin E3, 217 Inhibition of the. type I restriction-modification enzymes EcoB and EcoK by the gene 0.3 protein of bacteriophage T7, 567 INMAN: R. B. (see also KREV~IIIN, M. D.). 519 Insect flight, muscle, a new actin-like protein, arthrin, 443 IS50 transposition. essential sequences; the first base-pair, 487 ISBERCT, R. R. & SYVANEN, M.. Tn5 transposes independently of cointegrate resolution. Evidence for an alternate model for transposition, 69 Isopranyl ether lipids, bipolar, from archaehacteria; structure and polymorphism, 131 JAMES, M. N. 0. (see also MOULT, J.), 555 JEABNPIPATKUL, A. (see a$so ARAKX, H.), I91 JEMIOLO: D. K. (see also STARK, M. J. R.), 205 JONCBLOED, R. J. E. (see also MOORMANN, R. .I. M.),

419

KAESHERG. P. (see also DASMAHAPATRA, B.), I83 KAHN, M. (see also KREVOLIN, M. D.). 569 KAMPHUIS. I. G., DRENTH, J. & BAKER. E. N.. Thiol

proteases. Comparative studies based on the high-resolution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and II. and stem bromelain, 317 KAPTEIN, R., ZUIDERWEG, E. R. P., SCXBX~, R. >I., BOELENS, R. & VAN GUNSTEIKEN, W. I!‘., A protein structure from nuclear magnetic resonance data. Zac repressor headpiece, 179 KAUFUANN, KENXELL,

E. (see also GEISLER, N.), 173 D. (see also CANNISTRARO, V. J.).

241

KENSLER, R. W. (see also LEVINE, R. J. C.), 347 Kinetics and importance of the dimerization step in the folding pathway of the fi2 subunit of Escherichia co& tryptophan syntbase, 597 KN~~~zER, E. (see also MOSLER, E.), 589 KOCH, %I. B. J. (see also MOSLER, E.), 589 KOLTER, R. (see also FISNER, R. F.), 397 KORBA, B. E. (see aiso NAYS, J. B.), 611 KOTLARZ, KRAKOW, KREVOLIN.

D. (See ah hEyFUS, M.), 411 J. S. (see also EBFXCHT, R. H.), M. D. & CALENDAR, R.,

bacteriophage P4 DNA Pi o( gene product, 509

in

oitro.

KREVOLIN. RI. D., INMAN: R. B., CALEKDAR, R.. Racteriophage

Location

of the P4 origin,

519

91

Partial ROOF.

I’4

The replication of purification of the D.,

DXA

KAEN,

M.

replication.

$

x

INDEX

Eat repressor headpiece, structure from n.m.r. data: 179 ZacI mutations in constructed plasmids, 65 Lac~obacillus 30a bistidine decarboxylase. structure deter minntion at 343 A resolution, 455 LE &ICE, S. P. J. (see also EBRICHT, R. II.), 91 Lens, eye, and expression of the rat y-crystallin gene family, 419 LEONARD, M. (see also BULLAnD, B.), 443 LEONARD, K. (see also LEPAULT, 9.): 431 LEPAULT. J. & LEONARD, K., Three-dimensional structure of unstained frozen-hydrated extended tails of bacteriophage T4, 431 LEEK, A. M. (see also CNOTHIA, C.), 151 LEVINE, R. J. C. & KENSLER, R. W., Structure of short thick filaments from LimuEus muscle, 347 LEWIS. S. A.. GILMARTIN. M. E.. HALL. J. L. 8.x Cowara, N. J., Three expressed sequences’ within the human ,Ftubslin multigene family each define a distinct isotype. 11 Light chain dependent effects of actin binding on the S-i/S-2 swivel in myosin, 271 LimuZus muscle, structure of short thick filaments, 347 Lipids, bipolar isopranyl ether, from archaebacteria; structure and polymorphism, 131 Lru, A. Y. C., Mrenm,s, I?. A. EM., BERNARD~, A. & Bonsr, F., Trypanosome variant surface glycoprotein genes expressed early in infection, 383 LCBSEN, N. H. (see also ~@OORMANN, R. J. M.), 419 Lzzzar~, V. (see also G~LIK, A.), 131

MCREE,

D. E.,

~XARDSON,

J. s.

&

~CNARDSON,

D. c.,

Preliminary X-ray diffraction studies of acy! carrier protein from E’scherichia coli, 467 MgATP specifically controls in vitro self-assembly of vertebrate skeletal myosin in the physiological pN range. 159 Man and chimpanzee, high rate of variation in CpG dinucieotides and in short repeated sequences; evolution of the primate p-globin gene region, 21 MASAXI; H. & OETA, T., Cohcin E3 and its immunity genes, 217 Messenger RNA, lac, Escherichia coli, the 5’ ends, 241 Messenger RNAs from the transforming region of bovine papilloma virus type I, 541 ~~HELS, P. A. M. (see also LITJ, A. u. c.), 383 MILLER, L. & REISLER, E., Light chain dependent effects of actin binding on the S-l/S-2 swivel in myosin, 271 MILLER, J. H., Mutagenic specificity of ultraviolet light, 45 ~%I,LER,

J. H.,

ALBERTINI,

A.,

HOFER,

psi. $

COWBI?PINE.

C.,

Construction

of plasmids carrying ZaeP mutations (Appendix t0 MILLER, J. a., 45), 65 MILLER. J. P. (see also EBRIGKT, R. II.), 91 Molecular and functional organization of yeast plasmid pSR1; E91

Molecular rearrangement, stress-induced, in tendon collagen, 589 Monkev COS cells, nucleotide sequences responsible for the thermal inducibility of the &xophiZa small heat-shock protein genes, 469 MOQRE, 6. R. (see ah0 ROGERS, N. K.), 613 MOORMANN. B. J. M., DEN DUNNEN, J. T., JoNo33Lo~~, X.J.E., v*N LEEN, R. W.,

MEUYERJANS, LUBSEN, X.H.

J.. &

SCHOENMAKERS, J. 6. 6., Characterization of the rat ywrgstsllin gene family and its expression in the eye Iens, 419 MORENO-LOPEZ,~. (see a!so STENLUND, A.), 541 MOSLER, E:., FOLKHARD, W., KN~RZER, E., NEMETS~HEKGANSLER, W., NEMETSCHEK, TH. & KocIr, M. H. J., Stressinduced molecukw rearrangements in tendon collagen, 589 MOSSIE. E(. 6., YOUNG, M. w. & VARMUS, H. E., Extraehromosomal DNA forms of co+-iike transposable elements, F elements and middle repetititive DNA sequences in Drosophilu melanogaster. Variation in cultured cells and embryos, 31 MOCJLT, J., SUSSMAN. F. & JAMES, M. N. G., Electron density calculations as an extension of protein structure refinement. Streptomyees griseus protease A at 1.5 A resolution. 555 Mouse alpha-amylase loci, Amy-l” and Amy-2”, are closely linked, 359 Mouse strain CE/J, members of the Ar/Ly-2 alpha-amylase gene family contain duplicated 5’ termini: 1

Muconate lactonizing resolution, 353

enzyme.

Murine

cells, nucieosome is largely limited

erythroleukemia transcription and domainbfglobin

genes,

crystal

structure

at

6.5 A.

disruption precedes to t,he transcribed

909

Muscle. Muscle,

flight. insect. a new actin-like protein, arthrin, 443 ~&ulus, structure of short thick filaments, 447 MUTA, 7'. (see also An4Kr, RI.), 191 Mutagenic specificity of ultraviolet light, 45 Mutants, ad, of Escherichia coli, appawnt alteration in properties, 611 Mutation in an Escherichia coli ribosomal RSA operon that blocks the production of precursor 13 S ribosoma! RNA by RSsse 1% in viva and in &TO, 205 Mutations. iad. in constructed plasmids, 65 Mutations, point, that affect, translation initiation in the Ihcheriehia coli g&E gene, 411 Mutations, SV4-0 early promoter, that affect promoter function and autoregulation by large ‘k antigen, 229 Myosin. light chain dependent efhzts ofaotin binding on the S-l/ S-Z swiveij 271 Myosin, skeletal, vertebrate, MgATP specifically controls ITL riiro self-assembly in the physiologicai pH range. 1 RI; NAGARAJA, V., SHEPHERD, J. C. W., PRIFL. T. 8~ UIea~z, Two type I restriction enzymes from Snlmonrilfx Purification and DNA recognition sequences. 539 NEMETSCHEX, Ta. (see also MOSLER, E.), 589 NE~vIETS~~E~-G.~NSLER, Neurospora, genetic and

qa-2

genes,

H. control

(see

also

MosI,33R,

of chromatin

E.),

structure

T. .4.,

species.

,589

5’ to the yn-.r

79

NOAI, K.-L. (see also Gor,nx4x-, a.), 353 NIGION. V. M.. (see also SAVATIER, P.), 21

Nuclear magnetic resonance data and the determination of protein structure; 2ac repressor headpiece, 139 Nuclear resonance and distance geometry. an magnetic evaluation of their combined use for the determination of protein conformations in solution, 281 Nuclear magnetic resonance and dist,ance geometry. and the solution conformation of proteinase inhibitor 11% from bull seminal plasma, 295 Nuclear magnetic resonance, solid state. and protein structure. Residues 40 to 45 of bacteriophage fd coat protein. 367 Nuclear magnetic resonance spectrum, ‘H, of adenyIat,r kinnsr, assignment of aromatic spin systems, 341 Nucleosome disruption precedes transcription and is largely limited t,o the transcribed domain of giobin genes in mupine erythroleukemia cells. 109 Nuc!eotide sequences responsibie for the therma! inducibility of the Drosophila small heat-shock protein genes in monkey COS ee!ls, 469 OHTA, 'i'. (see also MASAKI, H.), %I7 0~x3, B. L. (see also GoLoivaN, A.), 353 OPELLA: S. J. (see also Cross, T. A.), 367

Organization, 191 ~HIIBCA.

molecular

Y. (see

also

hAKP.

and funct,ionai, H.).

of yeast

@mid

pSR 1.

101

P4 (see also Bacteriophage), 5G9. 519 Papain and actidin structures, amino acid sequence information for cathepsins B and M and stem bromelain: comparative studies of thiol proteases, 317 Papilloma virus type I (see also Virus), 541 $ARKS, E. H., ERNST. s. B,., &MLIN, R., XUCNG. N. H. & HACKERT. M. L.. Structure determination of histidinr decarboxylase from LaetobaciiE~,s .?Oa at 3.G A resolution, 455 Pausing. transcription, in the tryptophan operon, analysis of requirements, 397 PETTERSSON, C. (see also STBNLUND. A.), 541 pR dependence calculation for the redox potential of cyt~ochromr c--, interactions in globular proteins. 613 ___: electrostatic pN dependence of enthslpy changes: thermodynamirs of the reaction of ferric mvoulobin from A?zZusicr iimnciricr with . aside and fluoride, 667 y &IADNE~. 8. H. (see t&o &SAXAwA. c:.). 487

INDEX

PINSET-%RSTR&, T., MgATP specifically controls in a&o self-assembly of vertebrate skeletal myosin in the physiological pH range. 159 PITTET, A.-C. $ SCWIBLER, U., Mouse alpha-amglase loci, Amy-l” and Amy-Y, are closely linked. 359 I, yeast, moiecular and functional organization, 191 Plasmids carrying ZaeP mutations, construction, 65 Polymorphism and structure of bipolar isopranyl ether lipids from archaebacteria, I31 Precursor 23 S ribosomal RNA production by RNase III is blocked in viva and in vitro by a mutation in an Escherichia coli ribosomal RNA operon, 205 PEIFL, T. (see also NACARAJA, v.1, 579 Primate /?-globin gene region evolution. High rate of variation in CpG dinucleotides and in short repeated sequences between man and chimpanzee, 21 Promoter, early, SV40, mutations that affect promoter function and autoregulation by large T antigen, 229 Protease A: Streptom~yces griseus, at 1.5W resolution: electron density calculations as an extension of protein structure refinement, 555 Protein, a&n-like, new, arthrin~ in insect flight muscle, 443 Protein, seyl carrier, from &cherichia co& preliminary X-ray diffraction studies, 467 Protein conformations in solution: an evaluation of the combined use of n.m.r. and distance geometry for their determination, 281 Protein kinase, CAMP-dependent, crystallization studies; crystals of catalytic subunit difFract to 3.5 A resolution, 617 Protein structure from n.m.r. data; Zac repressor headpiece, 1’79 Protein structure refinement, and electron density calculations; Streptomyces @srus protease A at 1.5 A resolution, 555 Protein structure by solid state n.m.r. Residues 49 to 45 of bacteriophage id coat protein, 367 Proteinase inhibitor IIA from bull seminal plasma. solution conformation by ‘II n.m.r. and distance geometry, 295 Protoiilament unit. t’etrameric, of intermediate filaments, antiparailei orientation of the two double-stranded coiledcoils, Ii3 pSR1 plasmid, yeast, molecular and functional organization, 191 P~JMTZER. J. F., Co~ox~o, M. & CIARAMELLA, @I.: ?Jew control elements of bacteriophage T4 pre-replicative transcription, 249

qa-c

and qa-2 genes of Neuros.nora, chromatin structure, 79

and

genetic

control

of

Rat

y-crystallin gene family characterization, and expression in the eye lens, 419 Redox potential of cytochrome c551, calculation of the pII dependence: electrostatic interactions in globular proteins, 613 Regulation, autogenous, of transcription termination factor Rho, 495

REISLER, E. (see also i\ar~zsa, L.). 271 Replication of bact)eriophage P4 DNA in vitro. Partial purification of the P4 a gene product, 509 Replication, DNA, P4; location of the P4 origin, 519 Restriction enzymes, Pype I, two, from Salmonella species. Purification and DNA recognition sequences, 579 restriction-modi~~atio~~ enzymes EeoR and EcoK, inhibition by the gene 0.3 protein of bacteriophage T7, 567 Rho transcription termination factor, autogenous regulation, 495 RNA ribosomal operon, Escherichia co&, a mutation that blocks the production of precursor 23 S rRNA by RNase III in vitro and in vitro, 265 Ribosomal RNA operon of Escherichia coli, a mutation that blocks the production of precursor 23 S rRNA by RNase III in viva and in vi&o, 205 ~~~ARDSON. D. C. (see also MCREE, D. E.), 467 RICHARDSOX, $. S. (see also MCREE, D. E.), 467 RIGBY, P. W. J. (see also WOLPE, J.), 477 ROGERS, N. K., %I~oRE, G. R. & STERNBERC. M.J. E., Electrostatic interactions in globular proteins: calculation of the pH dependence of the redox potential of cytochrome f551, 613

xi

&&a,

P. & Gnoss, K.-II., Assignment of aromatic in the ‘II nuclear magnetic resonance spectrum kinase, 341

spin systems of adenylate

S-l/S-2 swivel in myosin, light chain dependent effects of actin binding, 271 SAKUIUI, T. (see also ARAKI, N.), 191 SdmoneEZa species, two type I restriction enzymes; purification and DNA recognition sequences, 579 SALZMAN, s. P. (see also DAS, G. C.), 229 SASAKAWA. C.. PHADNIS. S. H., CARLE, 6. F. & REMJ, D. E., Sequences essential for IS56 transposition. The &st base pair, 4X7 SAVATIER, P., TRABUCNET, G., FATJRE, C.. CHEBLOUNE, Y., &NJY. v., VERDPEK, 6. & NIGON, v. N., EvOll~tiOn Of the primate P-globin gene region. High rate of variation in CpG dinucleotides and in short repeated sequences between man and chimpanzee, 21 SCHEEK, R. ?& (see also KAPTEIN, R.), 179 SCHIBLER, U. (see also ETTET, A.-@.), 359 SCHOENMAKERS; J. 6. G. (see also MOORMANN. R. J. M.), 419 Self-assembly in vitro is specifically controlled by MgATP for vertebrate skeletal myosin in the physiologicai pN range. 159 Seminai plasma, bull, proteinase inhibitor IIA, solution conformation by ‘II n.m.r. and distance geometry, 295 Sense codons are found in specific contexts, 529 Sequence, amino acid, information for cathepsins B and II and stem bromeiain. and structures of papain and actinidin: comparative studies of thiol proteases, 317 Sequences, DNA, middle repetitive, extraehromosomal DNA forms in Drosophila melanogaster; variation in cultured cells and embryos, 31 Sequences, DNA, recognized by two type I restriction enzymes from Salmonella species, 579 Sequences essential for I550 transposition. The first base-pair, 487

Sequences, nucleotide, responsible for the thermal indueibiiity of the Drosophila small heat-shock protein genes in monkey COS cells, 469 Sequences, short repeated. high rate of variation between man and chimpanzee; evolution of the primate fi-globin gene region, 2B Sequences, three, within the human ,&tubulin multigene fa.mily each define a distinct isotype, 11 SHEFFEBY,M.(~~~ also COF~~EN, R. U.), 109 SHEPHERD. 9. C. W. (see also ?\TAGARAJA, V.). 579 Simian virus 40 (see also Virus), 229 Skeletal myosin, vertebrate, MgATP specifically cornrols in vitro self-assembly in the physiological pH range, I59 Solution conformation of proteinase inhibitor II-A from bull seminal plasma by i n.m.r. and distance geometry, 295 Solution conformation of oteins, an evaluation of the combined use of n.m.r. and distance geometry, 281 (see also AYME, A.), 469 ., Xuom, N.H.,ANomc30~, D. &TAYLOR, S. S., Crystallization studies of CAMP-dependent protein kinase. Crystals of catalytic subunit diffract to 3.5 A resolution; 617 Spin systems, aromatic, assignment in the “H n.m.r. spectrum of adenylate kinase, 341 Streptomyces griseus protease A at 1.5 A resolution; electron density calculations as an extension of protein structure refinement, 555 Structure of the black beetle virus genome and its functional implications, 183 Structure of chromatin, genetic control, and the ya-z and pa-2 genes of Neurospora, 79 Structure, crystal, of mueonate lactonizing enzyme at 6.5 A resolution, 353 Structure determination of histidine decarboxylase from Lactobacillus 30a at 36 A resolution, 455 Structure of the phase P of glycerol dialkyl nonitul tetraether, 146

Structure from Structure,

and polymorphism archaebacteria, 131 protein, from n.m.r.

of bipolar data;

isoprany?

Zac repressor

ether headpiece,

lipids I79

Strlacture of protein by solid state n.m.r.: residues 40 to 45 of bacteriophage fd coat protein, 367 Structure refinement for proteins, and eieetron density o;tlculations: streptomyces grisPuE protrase A at 1.5 A resolution. 555 Structure of short thick filaments from Gimuius muscle, 347 structure, three-dimensional, of unstained, frozen&ydrated extended tails of bacteriophage T4, 431 Structures. highresolution, Of papain and actinidin. and amino acid sequence information for cathepsins 83 and H and stem bromelain; comparative studies of thiol proteases, 317 STARK, M. J. R.. GOURSE, It. l,., JEMIoLo. D. X. & DAI~LBEKG, A. E.. A mutation in an Encheriehia coli ribosornai RNA operon that blocks the production Of precursor 23 S ribosomal RNA by RNase III in Gvo and in ,uitro, 205 STEAL. T. A. (see also GoLnr8AK, a.), 353 Stem bromelain and cathepsins B and H, amino acid sequence information, and structures of papa.in and actinidin; comparative studies of thiol proteases, 317 ST~SNLIINI~. A.. ZABIELSKI, J., AIIOLA. H.; MORENO-LOPEZ, J. & PETTERSSON, U., Messenger KNAs from the transforming region of bovine papilloma virus type I, 541 STERNBERG, M. J E. (see also ROGERS, N. I(.), 613 Stress-induced molecular rearrangement in tendon collagen, 589 STUE)I~, F. W. (see also KANY~PADI~AY. P. X.). 567 $~JSSMAN, P. (see also MOULT, J.), 555 Swivel, S-l/S-2, in myosin, light chain dependent effects of actin binding, 271 SYVANI~, M. (see also Psrrmm, R. R.), 69 T4 (see also Bacteriophage), 249. 431 ‘I’7 (see also Bacteriophage), 567 T antigen, large. autoregulation and SV40 early promoter mutations, 229 Tails, frozen-hydrated extended, unstained, of bacteriophage T4, three-dimensional structure, 431 Ta~srrivn, H. (see also ARAKI, TAYLOR, S. S. (see aiso SOWADSKK, J. M.), 617 Tendon collagen. stress-induced molecular rearrangement, 589 Thermal inducibility of the Drosophila small heat-shock genes in monkey COS cells, the nucleotide sequences responsible. 469 Thermodynamics of the reaction of ferric myoglobin from ,4&&a limacinu with azide and fluoride. Dependence of enthalpy changes on pB, 607 Thermclysin fragments, folding; identification of the minimum size of a carboxyl-terminal fragment that can fold into a native-like &able structure, 331 Thiol proteases. Comparative studies based on the highresolution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and IS, and stem bromelain, 317 ‘I’ISSIhRES. A. (See a!SO LYME, A.), 469 Tn.5 transposes independently of cointeprate resolution. Evidence for an alternative model for transposition: 69 ‘h.HI:CIEET, (:. (St%! aiS0 &AVATIER, P.), 21 Transcription pausing in the tryptophan “peron. analysis of requirements. 397 Transcription is preceded by nueleosome disruption which is largely limited to the transcribed domain of globin genes in murine erythroleukemia cells, 109 Transcription, pre-replicadive, T4, new control eiements. 249 Transcription termination factor Rho, autogenous regulation, 495 Transforming region mRNAs of bovine papilloma virus type I. 541 ‘hnslation initiation in the Escherichia coli galE gene. and affecting point mutations, 411 Transposition, IS50, essential sequences; the first base-pair. 487 Tropomyosin overlap removal. and the co-operative response to

Trgpanosome in infection,

variant 383

surface

glycoprotein

genes

expressed

Tryptophan synthase, Excherichiu CA. kinetics :and of the dimnerization step in the folding pathway subunit. 597 ~RUEBLOOD. c. E. (see also RAxII. T. I’.). 265 P-Tubdin. human, muttigene family. three expressed each define a distinct isotype, 11 Witraviolet Wsmo.

light, mutagenic K. (see also Aiiaxr.

specificity. H.), lili

early

importance of %e

/?,

scc~urncrs

45

VAK CUNSTEREN. W. F. (see also KAFTEIK, K.). 179 VAP: Lmx. X. W. (see also Moolttirav~, R. J. M.). 119 Variant surface giycoprotein genes. trypan”s”me, expressed eariv in infection 383 ~ARMUS: w. x. (SW .iSO IkY0SSIE. ii. hd.). 31 \7ERDIER. 6. (See alSO &VATIER, aj.), 21 Vertebrate skeletal myosin, MgATP specifically cont~~ols in vifm self-assemblly in the physiological pH range, 159 Virus black beetle, genome structure. and its functionai implications, 183 Virus. bovine papilkama type I. mRNAs from t,he transforming region. 541 Virus, S%‘40. early promoter mut,ations that affect promoter function and autoregulation by large T antigen. 2% VITA, i’. (See aiS DALZOPPO. D.). 331 WALSII. T. P.. TRI!EBLOOD. c. E., El-Ah-S, 1%. & VCEBER. a.. Removal of tropomyos!n overlap and the cooperative caieium coneentrat,ions of the actoresponse to increasing subfragment-l ATPase, 265 WEBER. !A. (see also WALsiI, T. P.). 265 WEBER. K. (see also GEISLER. S.). 173 WELLAITER, P. M. (see also 13onaRV. S.). i Wn,hu-t::. H. F. (see also {TOLPE. z.), 457 WIr,r,IAMsav. M P.. HAVEL, T. P. $ WtiTsEucJJ, I<.. Hclution conformation of proteinase inhibitor 11A from bull sernmal ptasma by ‘H nuclear magnetic ~SOII~J~CY~ and distance geometrv, “95

JXray

diffraction studies, prehminary, Of acyl from Eacherichia coli, 467 XUONC. N. H. (see also PARKS, E. Ii.). 455 Xuoso. S. H. (see also Sowarmtr, J. I%.), 617 Y

chromosome,

contests,

human,

529

isolation

and

carrier

characterization

protein

of

an