- Email: [email protected]
Cumulative subject index for volumes 13–14
GULATORY
TOXICOLOGY
AND
PHARMACOLOGY
14,3 15-320
Cumulative
( 199 1)
Subject Index’
Volumes 13-l 4 A
>sorption dermal, environmental contaminants in air, water, and soil: estimation of human exposure by multipathway models, 13, 36 ljudication pertaining to cancer causation: scientific, political, and legal conflicts, 13,309 gent Orange associatedfactsand fears:need for appropriate responses, editorial, 13, 115 r chromium concentrations in residential and industrial areas, health hazards, panel results, 13, 195 and water and soil, contaminants, human exposure via multiple pathways, estimation, 13, 36 liette, see Fosetyl A 1 lkylphenols risk assessment, utilization of quantitative structureactivity relationships, 14, 273 ngelicin dietary exposure, estimation, 14, 26 1 nimal testing relevance to human cancer risk assessment, editorial, 13,225
nnouncements International Society of Regulatory Toxicology and Pharmacology: International Achievement Award, 13,223
Workshop on Role of Science in Pesticide Management: International Comparison, Stockholm, Sweden, May 1992,14, 313 ntitumor activity and genotoxicity, hydroxyanthraquinones, quantum chemical study, 13, 185 hestos airborne concentrations in school buildings, transmission electron microscopic analysis, 13, 99 associated factsand fears:need for appropriate responses, editorial, 13, 115
related mesothelioma evidence for threshold in animals and humans, 13, 116 and unrelated mesothelioma, background incidence, animal and human evidence, 13, 133 6 Background incidence mesothelioma, animal and human evidence, 13, 133 Benzo[a]pyrene cancer risk assessment,review, 13, 170 Bioassays cancer, see Cancer bioassays Biomarkets for exposure assessment, decision model, 14,286 Biomonitoring data application in cancer risk estimation of chlordane and heptachlor, 14, 59 Bioresearch use of commercial nickel compounds: importance of composition verification for health risk assessment, 13,87
Bladder urinary, increased tumor incidence after aliette exposure (rat), 14, 3 Breast feeding benefits, relationship to presence of carcinogens in human milk, 13, 228 Buildings school, airborne concentrations of asbestos,transmission electron microscopic analysis, 13,99 C Cancer bioassays for assessment of cancer risks from chemicals, use of maximum tolerated dose, critique, 14,78 carcinogens administered by inhalation or oral exposure: comparative carcinogenic potency (mouse, rat), 13, 3
’ Boldface numbers indicate appropriate volume; lightface numbers indicate pagination. 315 0273-230019
1 $3.00
Copyright Q 1991 by Academic Press, Inc. All rights of repreduction in any form reserved.
316
CUMULATIVE
trichloroethylene, in evaluation of meta-analytic methods, 14, 178
Cancer causation adjudication: scientific, political, and legal conflicts, 13, 309 Cancer risk assessment and attending rule making, role of regulatory agencies, workshop report, 14,2 15 benzo[a]pyrene, review, 13, 170 chemicals, use of maximum tolerated dose in bioassays, critique, 14,78 chlordane and heptachlor, application of biomonitoring data, 14,59
chloroform in household water, significance of inhalation and dermal exposures, 14,297 propylene oxide: quantitative assessment of human carcinogenic potency by interspecies extrapolation, 14,229
quantitative risk prediction from rodent carcinogenic potencies: epidemiology of chemicals not definitively carcinogenic in humans, 14, 118 radon, lung cancer resulting from indoor exposure: risk screening methodology for policymakers, 14,245 relationship to presence of carcinogens in human milk, 13,228 relevance of animal tests, editorial, 13,225 2,3,7,8-tetrachlorodibenzo-p-dioxin, utilization of epidemiology data, 13, 150 Carcinogenicity aliette, evaluation (mouse, rat), 14, 3 chemicals in rodents, in quantitative prediction of human cancer risk: epidemiology of chemicals not definitively carcinogenic in humans, 14, 118 insulation wools: reassessmentof IARC evaluation, 14, 12 Carcinogens carcinogenicity mechanisms, role in cross-species extrapolation from rodent to human, 14, 147 natural, plant-derived, dietary exposure estimation, 14, 261 potency, compamtive effectsof different exposure routes (mouse, rat), 13,3 presence in human milk, relationship to cancer risk and benefits of breast feeding, 13,228 regulation, and cancer causation, adjudication: scientific, political, and legal contlicts, 13,309 Chemicals cancer risk assessment,use of maximum tolerated dose in bioassays,critique, 14, 78 causing cyr,-globulin nephropathy, risk assessment,editorial, 13, 1 contaminating drinking water, guideline development: survey and analysis of state-specificmethodologies, 13, 18
genotoxicity testing, role of mammalian cell mutation assays,evaluation, 14,24
SUBJECT INDEX not definitively carcinogenic in humans, epidemiology quantitative prediction of human cancer risk from rodent carcinogenic potencies, 14, 118 Children soil ingestion studies: qualitative and quantitative evi dence of soil ingestion, 13,278 Chlordane cancer risk estimation, application of biomonitoring data, 14,59
Chloroform in household water, inhalation and dermal exposures significance, 14, 297 Chromium contaminated soils in residential and industrial areas. health hazards, panel results, 13, 195 Cigarette smoking related mainstteam and environmental smoke,chemical and physical characteristics, literature analysis, 14! 88 Citrus fruits furocoumarins in, dietary exposure estimation, 14,26 1 Conservatism role in maximally exposed individual predictive expo. sure assessments:first-cut analysis, 14, 107 Contaminants chemical, in drinking water, guideline development: survey and analysis of state-specihc methodologies 13, 18
environmental in drinking water, standard setting processesand regulations: state versus federal approaches, 13, 293 human exposure via multiple pathways, estimation from air, water, and soil, 13, 36 Contraception with Multiload Cu 250 IUD, regulatory problem and action, 14, 41 Criteria documents for standard setting in occupational health, harmonization: workshop report, 13,24 1 Cross-species extrapolation animal to human predictive value of animal studies in toxicology, 14, 167 quantitative assessment of propylene oxide carcinogenic potency, 14,229 rodent to human quantitative prediction of human cancer risk from rodent carcinogenic potencies: epidemiology of chemicals not definitively carcinogenic in humans, 14, 118 renal tumor-inducing potential of d-timonene in male rats, human relevance and implications for risk assessment,13,70 role of carcinogenicity mechanisms of chemical carcinogens, 14, 147
CUMULATIVE
D Diet furocoumarins in, exposure estimation, 14,26 1 Dioxin, see 2,3,7,8-Tetrachlorodibenzo-p-dioxin Disaster preparedness in hazardous industries: principles of risk analysis, 13, 62 Drinking water chemical contaminants, guideline development: survey and analysis of state-specific methodologies, 13, 18 environmental contaminants, standard setting processes and regulations: state versus federal approaches,
SUBJECT
Flavor and Extract Manufacturers’ Association expert panel, GRAS evaluation of flavoring substances, review, 14,48 Flavoring substances GRAS evaluation by expert panel of FEMA, review, 14,48
Fosetyl A 1 carcinogenic potential, evaluation (mouse, rat), 14,3 Fungicides aliette, evaluation of carcinogenic potential (mouse, rat), 14, 3 Furocoumarins dietary exposure, estimation, 14, 26 1
13,293
G
E Ecotoxicity testing plant molluscicide Endod, 14, 189 Education and motivation, in public health and nutrition, comparison with regulation, editorial, 14,2 13 Endod as plant molluscicide, safety evaluation, 14, I89 Epidemiology chemicals not definitively carcinogenic in humans: quantitative prediction of human cancer risk from rodent carcinogenic potencies, 14, 1 I8 data utilization in assessmentof cancer risk of 2,3,7,8tetrachlorodibenzo-Moxin, 13, 150 Exposure assessment biomarkers for, decision model, 14,286 contaminants in soil: development of model for estimating soil ingestion recovery values in related studies, 13,263 predictive, maximally exposed individual, role of conservatism: first-cut analysis, 14, 107 Exposure limits occupational, health-based, harmonization of criteria documents for standard setting in, workshop report,
317
INDEX
Generally-recognized-as-safe evaluation, see GRAS evaluation Genes mutation assaysin mammalian cells, role in testing of chemical genotoxicity, evaluation, 14,24 Genotoxicity and antitumor activity, hydroxyanthraquinones, quantum chemical study, 13, 185 carcinogens, related mechanisms, role in cross-species extrapolation from rodent to human, 14, 147 chemicals, testing, role of mammalian cell mutation assays,evaluation, 14, 24 cu,,-Globulin nephropathy, causative chemicals, risk assessment,editorial, 13, 1 GRAS evaluation flavoring substancesby expert panel of FEMA, evolution of process, review, 14,48 Chexylresorcinol as processing aid for prevention of melanosis in shrimp, 14, 202 Guidelines for chemical contaminants of drinking water, development: survey and analysis of state-specific methodologies, 13, 18
13,241
Exposure route carcinogens via ingestion or inhalation, comparative effects on carcinogen potency (mouse, rat), 13,3 environmental contaminants via multiple pathways, estimation from air, water, and soil (human), 13, 36
F FEMA, seeFlavor and Extract Manufacturem’ Association Fibers mineral, man-made, carcinogen&: reassessment of IARC evaluation, 14, 12
H Health associatedfactsand feats:need for appropriate responses, editorial, 13, 115 occupation standard setting harmonization of criteria documents for, workshop report, 13,241 public, see fiblic health Heptachlor cancer risk estimation, application of biomonitoring data, 14,59 4-Hexylresorcinol as processing aid
for prevention of melanosis in shrimp, GRAS evaluation, 14,202
318
CUMULATIVE
SUBJECT INDEX
Hydroxyanthraquinones genotoxic and antitumor activities, quantum chemical study, 13, 185
Industry hazardous, risk analysis in regulatory decision making for, principles, 13, 62 interfacing with quality assurance and regulations, editorial, 14, 1 point of view in evaluation of applicability of mammalian cell mutation assaysin testing of chemical genotoxicity, 14, 24 Ingestion chromium-contaminated soils in residential and industrial areas, health hazards, panel results, 13, 195 environmental contaminants in air, water, and soil: estimation of human exposure by multipathway models, 13, 36 and inhalation, carcinogens, comparative effects on carcinogen potency (mouse, rat), 13,3 soil, studies estimation of recovery values in, model development, 13,263
qualitative and quantitative evidence of soil ingestion, 13,278
Inhalation chloroform in household water, significance, 14, 297 environmental contaminants in air, water, and soil: estimation of human exposure by multipathway models, 13, 36 and ingestion, carcinogens, comparative effectson carcinogen potency (mouse, rat), 13, 3 Insulation wools carcinogenicity: reassessment of IARC evaluation, 14, 12 International Agency for Research on Cancer evaluation of insulation wool carcinogenicity, reassessment, 14, 12 Intrauterine contraceptive device (IUD) Multiload Cu 250, regulatory problems and actions, 14, 41 K
Kidney tumor-inducing potential of d-limonene in male rats, human relevance and implications for risk assessment, 13, 70
Law and politics and science, conflicts in adjudicating cancer causation, 13,309 d-Limonene renal tumor-inducing potential in male rata, human relevance and implications for risk assessment,13, 70 M
Maximally exposed individual predictive exposure assessments,role of conservatism: first-cut analysis, 14, 107 Maximum contaminant levels trihalomethanes: significance of inhalation and dermal exposures to chloroform in household water, 14, 297 Maximum tolerated dose utilization in bioassays for cancer risk assessment of chemicals, critique, 14, 78 Melanosis prevention in shrimp, 4-hexylresorcinol as processing aid for, GRAS evaluation, 14, 202 Meta-analysis methodology for combining data for improvement of quantitative risk assessment,14, 178 Milk presence of carcinogens, relationship to cancer risk and benefits of breast feeding (human), 13,228 MNDO/H calculations semiempirical, in quantum chemical study of hydroxyanthraquinone genotoxicity and antitumor activities, 13, 185 Models decision, for biomarkers of exposure assessment, 14, 286
for estimating soil ingestion recovery values in related studies, development, 13,263 multipathway multimedia, for estimating human exposure to environmental contaminants in air, water, and soil, 13, 36 Molluscicide plantderived: safety evaluation of Endod, 14, 189 Motivation and education, in public health and nutrition, comparison with regulation, editorial, 14, 2 I3 Mutagenicity testing plant molluscicide Endod, 14, 189 Mutations genetic, assaysin mammalian cells, role in testing of chemical genotoxicity, evaluation, 14, 24
L
N
Labeling commercial nickel compounds, errors in, implications for reliable health risk assessment, 13, 87
Nephropathy a~,-globulin, causative chemicals, risk assessment, editorial, 13, 1
CUMULATIVE Jersey Hudson County, residential and industrial areas, health hazards posed by chromium-contaminated soils, panel results, 13, 195 Nickel commercial compounds, composition verification for reliable health risk assessment, 13, 87 Nutrition and public health: regulation versus education and motivation, editorial, 14, 213 New
0 Obituary Alexander M. Schmidt, 14, 106 Office of Management and Budget annual report of 1990, major issues raised from perspective of regulatory agencies, comment, 14,223
SUBJECT INDEX
319
role in rule making with regard to cancer risk assessment, workshop report, 14,2 15 Regulatory policies for carcinogens, role of carcinogenicity mechanisms (human, rodent), 14, 147 for hazardous industries: principles of risk analysis, 13, 62 problem and action concerning Multiload Cu 250 IUD, 14,41
in public health and nutrition, comparison with education and motivation, editorial, 14, 2 13 and quality assurance, industry interfacing with, editorial, 14, 1 and standard setting processes, for environmental contaminants in drinking water: state versus federal approaches, 13,293 Risk assessment airborne asbestos concentrations in school buildings, 13,99
P
Pharmacokinetics propylene oxide: quantitative assessment of human carcinogenic potency by interspecies extrapolation, 14,229
Policymakers radon risk screening methodology for, estimation of lung cancer risk resulting from indoor exposure, 14,245 Politics and law and science, conflicts in adjudicating cancer causation, 13, 309 Propylene oxide carcinogenic potency, extrapolation from animal to human: pharmacokinetics and risk assessment, 14, 229 Psoralen dietary exposure, estimation, 14, 26 1 Public health and nutrition: regulation versus education and motivation, editorial, 14,2 13 Q Quality assurance and regulations, industry interfacing with, editorial, 14, 1
alkylphenols, utilization of quantitative structureactivity relationships, 14, 273 cancer, see Cancer risk assessment chemicals causing a&obulin nephropathy. editorial, 13, 1 chromium-contaminated soils in residential and industrial areas, panel results, 13, 195 commercial nickel compounds, reliability, importance of composition verification, 13,87 d-limonene use as flavor and fragrance, implications of renal tumor-inducing potential in male rats, 13, 70 maximally exposed individual predictive model, role of conservatism: first-cut analysis, 14, 107 quantitative, improvement by combining data: metaanalysis, 14, 178 in regulatory decision making for hazardous industries, principles, 13, 62 review of scientific basis, discussion of OMB report in light of, comment, 14,223 science-based methodology: predictive value of animal studies in toxicology, 14, 167 Rule making with regard to cancer risk assessment,role of regulatory agencies, workshop report, 14, 2 15
R
S
Radon indoor exposure, resulting lung cancer risk, screening methodology for policymakers, 14,245 Regulatory agencies major issuesraised by OMB report from perspective of, comment, 14,223 point of view in evaluation of applicability of mammalian cell mutation assaysin testing of chemical genotoxicity, 14, 24
Schistosomiasis potential control by plant molluscicide Endod: safety evaluation, 14, 189 Science and politics and law, conflicts in adjudicating cancer causation, 13, 309 Screening radon risks, methodology for policymakers: lung cancer . ^ nsk resulting tram indoor radon exposure, 14,245
320
CUMULATIVE
SUBJECT INDEX
Serum 2,3,7,8-tetrachlorodibenzo-flioxin levels in exposed humans, in cancer risk assessment, 13, 150 Shrimp melanosis prevention, Chexylresorcinol as processing aid, GRAS evaluation, 14, 202 Skin exposure to chloroform in household water, significance, 14,297
health hazard of chromium-contaminated soils in residential and industrial areas, panel results, 13, 195 uptake of environmental contaminants in water and soil: estimation of human exposure by multipathway models, 13, 36 Smoking, see Cigarette smoking Soil chromium-contaminated, in residential and industrial areas, health hazards, panel results, 13, 195 ingestion studies estimation of recovery values in, model development, 13,263 qualitative and quantitative evidence of soil ingestion, 13,278
and water and air, contaminants, human exposure via multiple pathways, estimation, 13, 36 Standard setting in occupational health, harmonization of criteria documents for, workshop report, 13,24 1 processes and regulations for environmental contaminants in drinking water: state versus federal approaches, 13,293 Structure-activity relationships quantitative, in risk assessment for alkylphenols, 14, 273 Surveys national, state-specific methodologies for developing guidelines for chemical contaminants of drinking water, analysis, 13, 18 T
TCDD, see 2,3,7,8-Tetrachlorodibenzo-p-dioxin 2,3,7,8-Tetrachlorodibenzo-p-dioxin associatedfactsand fears:need for appropriate responses., editorial, 13, 115 cancer risk assessment,utilization of epidemiology da@
Toxicity testing plant molluscicide Endod, 14, 189 Toxicology animal studies in, predictive value, 14, 167 Trichloroethylene cancer bioassays, in evaluation of meta-analytic methods,14,
178
Trihalomethanes maximum contaminant levels:significance of inhalation and dermal exposures to chloroform in household water, 14,297 Tumors lung cancer, risk resulting from indoor radon exposure, screening methodology for policymakers, 14,245 mesothelioma asbestos-related, evidence for threshold in animals and humans, 13, 116 background incidence, animal and human evidence 13,133
renal, inducing potential of d-limonene in male rats, human relevance and implications for risk assessment, 13,70 urinary bladder, increased incidence after aliette exposure (rat), 14, 3
U
Umbelliferous plants edible, furocoumarins in, dietary exposure estimation, 14,261 Uncertainty maximally exposed individual predictive exposure assessments for dealing with, role of conservatism: first-cut analysis, 14,107 United States state versus federal approaches to standard setting processesand regulations for environmental contaminants in drinking water, 13,293 state-specific methodologies for deriving drinking water guidelines for chemical contaminants, survey and analysis, 13, 18
W
13,150
Thresholds asbestos-related mesothehoma, evidence in animals and humans, 13, 116 Tobacco smoke mainstream and environmental, chemical and physical characteristics, literature analysis, 14,88
Water and air and soil, contaminants, human exposure via multiple pathways, estimation, 13, 36 for drinking, see Drinking water household, chloroform in, inhalation and dermal exposures, siificance, 14,297
TOXICOLOGY
AND
PHARMACOLOGY
14,3 15-320
Cumulative
( 199 1)
Subject Index’
Volumes 13-l 4 A
>sorption dermal, environmental contaminants in air, water, and soil: estimation of human exposure by multipathway models, 13, 36 ljudication pertaining to cancer causation: scientific, political, and legal conflicts, 13,309 gent Orange associatedfactsand fears:need for appropriate responses, editorial, 13, 115 r chromium concentrations in residential and industrial areas, health hazards, panel results, 13, 195 and water and soil, contaminants, human exposure via multiple pathways, estimation, 13, 36 liette, see Fosetyl A 1 lkylphenols risk assessment, utilization of quantitative structureactivity relationships, 14, 273 ngelicin dietary exposure, estimation, 14, 26 1 nimal testing relevance to human cancer risk assessment, editorial, 13,225
nnouncements International Society of Regulatory Toxicology and Pharmacology: International Achievement Award, 13,223
Workshop on Role of Science in Pesticide Management: International Comparison, Stockholm, Sweden, May 1992,14, 313 ntitumor activity and genotoxicity, hydroxyanthraquinones, quantum chemical study, 13, 185 hestos airborne concentrations in school buildings, transmission electron microscopic analysis, 13, 99 associated factsand fears:need for appropriate responses, editorial, 13, 115
related mesothelioma evidence for threshold in animals and humans, 13, 116 and unrelated mesothelioma, background incidence, animal and human evidence, 13, 133 6 Background incidence mesothelioma, animal and human evidence, 13, 133 Benzo[a]pyrene cancer risk assessment,review, 13, 170 Bioassays cancer, see Cancer bioassays Biomarkets for exposure assessment, decision model, 14,286 Biomonitoring data application in cancer risk estimation of chlordane and heptachlor, 14, 59 Bioresearch use of commercial nickel compounds: importance of composition verification for health risk assessment, 13,87
Bladder urinary, increased tumor incidence after aliette exposure (rat), 14, 3 Breast feeding benefits, relationship to presence of carcinogens in human milk, 13, 228 Buildings school, airborne concentrations of asbestos,transmission electron microscopic analysis, 13,99 C Cancer bioassays for assessment of cancer risks from chemicals, use of maximum tolerated dose, critique, 14,78 carcinogens administered by inhalation or oral exposure: comparative carcinogenic potency (mouse, rat), 13, 3
’ Boldface numbers indicate appropriate volume; lightface numbers indicate pagination. 315 0273-230019
1 $3.00
Copyright Q 1991 by Academic Press, Inc. All rights of repreduction in any form reserved.
316
CUMULATIVE
trichloroethylene, in evaluation of meta-analytic methods, 14, 178
Cancer causation adjudication: scientific, political, and legal conflicts, 13, 309 Cancer risk assessment and attending rule making, role of regulatory agencies, workshop report, 14,2 15 benzo[a]pyrene, review, 13, 170 chemicals, use of maximum tolerated dose in bioassays, critique, 14,78 chlordane and heptachlor, application of biomonitoring data, 14,59
chloroform in household water, significance of inhalation and dermal exposures, 14,297 propylene oxide: quantitative assessment of human carcinogenic potency by interspecies extrapolation, 14,229
quantitative risk prediction from rodent carcinogenic potencies: epidemiology of chemicals not definitively carcinogenic in humans, 14, 118 radon, lung cancer resulting from indoor exposure: risk screening methodology for policymakers, 14,245 relationship to presence of carcinogens in human milk, 13,228 relevance of animal tests, editorial, 13,225 2,3,7,8-tetrachlorodibenzo-p-dioxin, utilization of epidemiology data, 13, 150 Carcinogenicity aliette, evaluation (mouse, rat), 14, 3 chemicals in rodents, in quantitative prediction of human cancer risk: epidemiology of chemicals not definitively carcinogenic in humans, 14, 118 insulation wools: reassessmentof IARC evaluation, 14, 12 Carcinogens carcinogenicity mechanisms, role in cross-species extrapolation from rodent to human, 14, 147 natural, plant-derived, dietary exposure estimation, 14, 261 potency, compamtive effectsof different exposure routes (mouse, rat), 13,3 presence in human milk, relationship to cancer risk and benefits of breast feeding, 13,228 regulation, and cancer causation, adjudication: scientific, political, and legal contlicts, 13,309 Chemicals cancer risk assessment,use of maximum tolerated dose in bioassays,critique, 14, 78 causing cyr,-globulin nephropathy, risk assessment,editorial, 13, 1 contaminating drinking water, guideline development: survey and analysis of state-specificmethodologies, 13, 18
genotoxicity testing, role of mammalian cell mutation assays,evaluation, 14,24
SUBJECT INDEX not definitively carcinogenic in humans, epidemiology quantitative prediction of human cancer risk from rodent carcinogenic potencies, 14, 118 Children soil ingestion studies: qualitative and quantitative evi dence of soil ingestion, 13,278 Chlordane cancer risk estimation, application of biomonitoring data, 14,59
Chloroform in household water, inhalation and dermal exposures significance, 14, 297 Chromium contaminated soils in residential and industrial areas. health hazards, panel results, 13, 195 Cigarette smoking related mainstteam and environmental smoke,chemical and physical characteristics, literature analysis, 14! 88 Citrus fruits furocoumarins in, dietary exposure estimation, 14,26 1 Conservatism role in maximally exposed individual predictive expo. sure assessments:first-cut analysis, 14, 107 Contaminants chemical, in drinking water, guideline development: survey and analysis of state-specihc methodologies 13, 18
environmental in drinking water, standard setting processesand regulations: state versus federal approaches, 13, 293 human exposure via multiple pathways, estimation from air, water, and soil, 13, 36 Contraception with Multiload Cu 250 IUD, regulatory problem and action, 14, 41 Criteria documents for standard setting in occupational health, harmonization: workshop report, 13,24 1 Cross-species extrapolation animal to human predictive value of animal studies in toxicology, 14, 167 quantitative assessment of propylene oxide carcinogenic potency, 14,229 rodent to human quantitative prediction of human cancer risk from rodent carcinogenic potencies: epidemiology of chemicals not definitively carcinogenic in humans, 14, 118 renal tumor-inducing potential of d-timonene in male rats, human relevance and implications for risk assessment,13,70 role of carcinogenicity mechanisms of chemical carcinogens, 14, 147
CUMULATIVE
D Diet furocoumarins in, exposure estimation, 14,26 1 Dioxin, see 2,3,7,8-Tetrachlorodibenzo-p-dioxin Disaster preparedness in hazardous industries: principles of risk analysis, 13, 62 Drinking water chemical contaminants, guideline development: survey and analysis of state-specific methodologies, 13, 18 environmental contaminants, standard setting processes and regulations: state versus federal approaches,
SUBJECT
Flavor and Extract Manufacturers’ Association expert panel, GRAS evaluation of flavoring substances, review, 14,48 Flavoring substances GRAS evaluation by expert panel of FEMA, review, 14,48
Fosetyl A 1 carcinogenic potential, evaluation (mouse, rat), 14,3 Fungicides aliette, evaluation of carcinogenic potential (mouse, rat), 14, 3 Furocoumarins dietary exposure, estimation, 14, 26 1
13,293
G
E Ecotoxicity testing plant molluscicide Endod, 14, 189 Education and motivation, in public health and nutrition, comparison with regulation, editorial, 14,2 13 Endod as plant molluscicide, safety evaluation, 14, I89 Epidemiology chemicals not definitively carcinogenic in humans: quantitative prediction of human cancer risk from rodent carcinogenic potencies, 14, 1 I8 data utilization in assessmentof cancer risk of 2,3,7,8tetrachlorodibenzo-Moxin, 13, 150 Exposure assessment biomarkers for, decision model, 14,286 contaminants in soil: development of model for estimating soil ingestion recovery values in related studies, 13,263 predictive, maximally exposed individual, role of conservatism: first-cut analysis, 14, 107 Exposure limits occupational, health-based, harmonization of criteria documents for standard setting in, workshop report,
317
INDEX
Generally-recognized-as-safe evaluation, see GRAS evaluation Genes mutation assaysin mammalian cells, role in testing of chemical genotoxicity, evaluation, 14,24 Genotoxicity and antitumor activity, hydroxyanthraquinones, quantum chemical study, 13, 185 carcinogens, related mechanisms, role in cross-species extrapolation from rodent to human, 14, 147 chemicals, testing, role of mammalian cell mutation assays,evaluation, 14, 24 cu,,-Globulin nephropathy, causative chemicals, risk assessment,editorial, 13, 1 GRAS evaluation flavoring substancesby expert panel of FEMA, evolution of process, review, 14,48 Chexylresorcinol as processing aid for prevention of melanosis in shrimp, 14, 202 Guidelines for chemical contaminants of drinking water, development: survey and analysis of state-specific methodologies, 13, 18
13,241
Exposure route carcinogens via ingestion or inhalation, comparative effects on carcinogen potency (mouse, rat), 13,3 environmental contaminants via multiple pathways, estimation from air, water, and soil (human), 13, 36
F FEMA, seeFlavor and Extract Manufacturem’ Association Fibers mineral, man-made, carcinogen&: reassessment of IARC evaluation, 14, 12
H Health associatedfactsand feats:need for appropriate responses, editorial, 13, 115 occupation standard setting harmonization of criteria documents for, workshop report, 13,241 public, see fiblic health Heptachlor cancer risk estimation, application of biomonitoring data, 14,59 4-Hexylresorcinol as processing aid
for prevention of melanosis in shrimp, GRAS evaluation, 14,202
318
CUMULATIVE
SUBJECT INDEX
Hydroxyanthraquinones genotoxic and antitumor activities, quantum chemical study, 13, 185
Industry hazardous, risk analysis in regulatory decision making for, principles, 13, 62 interfacing with quality assurance and regulations, editorial, 14, 1 point of view in evaluation of applicability of mammalian cell mutation assaysin testing of chemical genotoxicity, 14, 24 Ingestion chromium-contaminated soils in residential and industrial areas, health hazards, panel results, 13, 195 environmental contaminants in air, water, and soil: estimation of human exposure by multipathway models, 13, 36 and inhalation, carcinogens, comparative effects on carcinogen potency (mouse, rat), 13,3 soil, studies estimation of recovery values in, model development, 13,263
qualitative and quantitative evidence of soil ingestion, 13,278
Inhalation chloroform in household water, significance, 14, 297 environmental contaminants in air, water, and soil: estimation of human exposure by multipathway models, 13, 36 and ingestion, carcinogens, comparative effectson carcinogen potency (mouse, rat), 13, 3 Insulation wools carcinogenicity: reassessment of IARC evaluation, 14, 12 International Agency for Research on Cancer evaluation of insulation wool carcinogenicity, reassessment, 14, 12 Intrauterine contraceptive device (IUD) Multiload Cu 250, regulatory problems and actions, 14, 41 K
Kidney tumor-inducing potential of d-limonene in male rats, human relevance and implications for risk assessment, 13, 70
Law and politics and science, conflicts in adjudicating cancer causation, 13,309 d-Limonene renal tumor-inducing potential in male rata, human relevance and implications for risk assessment,13, 70 M
Maximally exposed individual predictive exposure assessments,role of conservatism: first-cut analysis, 14, 107 Maximum contaminant levels trihalomethanes: significance of inhalation and dermal exposures to chloroform in household water, 14, 297 Maximum tolerated dose utilization in bioassays for cancer risk assessment of chemicals, critique, 14, 78 Melanosis prevention in shrimp, 4-hexylresorcinol as processing aid for, GRAS evaluation, 14, 202 Meta-analysis methodology for combining data for improvement of quantitative risk assessment,14, 178 Milk presence of carcinogens, relationship to cancer risk and benefits of breast feeding (human), 13,228 MNDO/H calculations semiempirical, in quantum chemical study of hydroxyanthraquinone genotoxicity and antitumor activities, 13, 185 Models decision, for biomarkers of exposure assessment, 14, 286
for estimating soil ingestion recovery values in related studies, development, 13,263 multipathway multimedia, for estimating human exposure to environmental contaminants in air, water, and soil, 13, 36 Molluscicide plantderived: safety evaluation of Endod, 14, 189 Motivation and education, in public health and nutrition, comparison with regulation, editorial, 14, 2 I3 Mutagenicity testing plant molluscicide Endod, 14, 189 Mutations genetic, assaysin mammalian cells, role in testing of chemical genotoxicity, evaluation, 14, 24
L
N
Labeling commercial nickel compounds, errors in, implications for reliable health risk assessment, 13, 87
Nephropathy a~,-globulin, causative chemicals, risk assessment, editorial, 13, 1
CUMULATIVE Jersey Hudson County, residential and industrial areas, health hazards posed by chromium-contaminated soils, panel results, 13, 195 Nickel commercial compounds, composition verification for reliable health risk assessment, 13, 87 Nutrition and public health: regulation versus education and motivation, editorial, 14, 213 New
0 Obituary Alexander M. Schmidt, 14, 106 Office of Management and Budget annual report of 1990, major issues raised from perspective of regulatory agencies, comment, 14,223
SUBJECT INDEX
319
role in rule making with regard to cancer risk assessment, workshop report, 14,2 15 Regulatory policies for carcinogens, role of carcinogenicity mechanisms (human, rodent), 14, 147 for hazardous industries: principles of risk analysis, 13, 62 problem and action concerning Multiload Cu 250 IUD, 14,41
in public health and nutrition, comparison with education and motivation, editorial, 14, 2 13 and quality assurance, industry interfacing with, editorial, 14, 1 and standard setting processes, for environmental contaminants in drinking water: state versus federal approaches, 13,293 Risk assessment airborne asbestos concentrations in school buildings, 13,99
P
Pharmacokinetics propylene oxide: quantitative assessment of human carcinogenic potency by interspecies extrapolation, 14,229
Policymakers radon risk screening methodology for, estimation of lung cancer risk resulting from indoor exposure, 14,245 Politics and law and science, conflicts in adjudicating cancer causation, 13, 309 Propylene oxide carcinogenic potency, extrapolation from animal to human: pharmacokinetics and risk assessment, 14, 229 Psoralen dietary exposure, estimation, 14, 26 1 Public health and nutrition: regulation versus education and motivation, editorial, 14,2 13 Q Quality assurance and regulations, industry interfacing with, editorial, 14, 1
alkylphenols, utilization of quantitative structureactivity relationships, 14, 273 cancer, see Cancer risk assessment chemicals causing a&obulin nephropathy. editorial, 13, 1 chromium-contaminated soils in residential and industrial areas, panel results, 13, 195 commercial nickel compounds, reliability, importance of composition verification, 13,87 d-limonene use as flavor and fragrance, implications of renal tumor-inducing potential in male rats, 13, 70 maximally exposed individual predictive model, role of conservatism: first-cut analysis, 14, 107 quantitative, improvement by combining data: metaanalysis, 14, 178 in regulatory decision making for hazardous industries, principles, 13, 62 review of scientific basis, discussion of OMB report in light of, comment, 14,223 science-based methodology: predictive value of animal studies in toxicology, 14, 167 Rule making with regard to cancer risk assessment,role of regulatory agencies, workshop report, 14, 2 15
R
S
Radon indoor exposure, resulting lung cancer risk, screening methodology for policymakers, 14,245 Regulatory agencies major issuesraised by OMB report from perspective of, comment, 14,223 point of view in evaluation of applicability of mammalian cell mutation assaysin testing of chemical genotoxicity, 14, 24
Schistosomiasis potential control by plant molluscicide Endod: safety evaluation, 14, 189 Science and politics and law, conflicts in adjudicating cancer causation, 13, 309 Screening radon risks, methodology for policymakers: lung cancer . ^ nsk resulting tram indoor radon exposure, 14,245
320
CUMULATIVE
SUBJECT INDEX
Serum 2,3,7,8-tetrachlorodibenzo-flioxin levels in exposed humans, in cancer risk assessment, 13, 150 Shrimp melanosis prevention, Chexylresorcinol as processing aid, GRAS evaluation, 14, 202 Skin exposure to chloroform in household water, significance, 14,297
health hazard of chromium-contaminated soils in residential and industrial areas, panel results, 13, 195 uptake of environmental contaminants in water and soil: estimation of human exposure by multipathway models, 13, 36 Smoking, see Cigarette smoking Soil chromium-contaminated, in residential and industrial areas, health hazards, panel results, 13, 195 ingestion studies estimation of recovery values in, model development, 13,263 qualitative and quantitative evidence of soil ingestion, 13,278
and water and air, contaminants, human exposure via multiple pathways, estimation, 13, 36 Standard setting in occupational health, harmonization of criteria documents for, workshop report, 13,24 1 processes and regulations for environmental contaminants in drinking water: state versus federal approaches, 13,293 Structure-activity relationships quantitative, in risk assessment for alkylphenols, 14, 273 Surveys national, state-specific methodologies for developing guidelines for chemical contaminants of drinking water, analysis, 13, 18 T
TCDD, see 2,3,7,8-Tetrachlorodibenzo-p-dioxin 2,3,7,8-Tetrachlorodibenzo-p-dioxin associatedfactsand fears:need for appropriate responses., editorial, 13, 115 cancer risk assessment,utilization of epidemiology da@
Toxicity testing plant molluscicide Endod, 14, 189 Toxicology animal studies in, predictive value, 14, 167 Trichloroethylene cancer bioassays, in evaluation of meta-analytic methods,14,
178
Trihalomethanes maximum contaminant levels:significance of inhalation and dermal exposures to chloroform in household water, 14,297 Tumors lung cancer, risk resulting from indoor radon exposure, screening methodology for policymakers, 14,245 mesothelioma asbestos-related, evidence for threshold in animals and humans, 13, 116 background incidence, animal and human evidence 13,133
renal, inducing potential of d-limonene in male rats, human relevance and implications for risk assessment, 13,70 urinary bladder, increased incidence after aliette exposure (rat), 14, 3
U
Umbelliferous plants edible, furocoumarins in, dietary exposure estimation, 14,261 Uncertainty maximally exposed individual predictive exposure assessments for dealing with, role of conservatism: first-cut analysis, 14,107 United States state versus federal approaches to standard setting processesand regulations for environmental contaminants in drinking water, 13,293 state-specific methodologies for deriving drinking water guidelines for chemical contaminants, survey and analysis, 13, 18
W
13,150
Thresholds asbestos-related mesothehoma, evidence in animals and humans, 13, 116 Tobacco smoke mainstream and environmental, chemical and physical characteristics, literature analysis, 14,88
Water and air and soil, contaminants, human exposure via multiple pathways, estimation, 13, 36 for drinking, see Drinking water household, chloroform in, inhalation and dermal exposures, siificance, 14,297