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Discrimination of normotensives (N) and essential hypertensives (EH) by means of humoral parameters
PROSTAGLANDINS
DISCRIMINATION OF NORMOTENSIVES BY MEANS OF HUMORAL PARAMETERS.
(N) AND
ESSENTIAL
HYPERTENSIVES
PELESKA, J., ZVAROVA, J., KUCEROVA, V., JINDRA, A., SAVLIKOVA, LINHARTOVA, J., ORT, J., JAROLIM, M., RIPKA, 0. 2nd Medical
Department,
Charles
University,
Prague,
(EH)
J.,
Czechoslovakia
Some hypotheses suggest a generalised defect of sodium and potassium transport in cells as the primary factor in the pathogenesis of EH. In 43 men and women belonging to stages I and II of EH (WHO) and 21 N men and women plasma concentrations of prostaglandins E and F (PGE, PGF), aldosterone (ALD), cortisol (CORT), natriurl (Na) potassium (K) plasma renin activity (PRA) and dopamine-beta-hydroxylase activity (DBH) in peripheral venous blood and in blood of renal veins (in EH only) and near to the termination of right suprarenal vein were determined. Linear discriminant functions (LDF) among 3 groups (N, EH I, EH II) for men and women separately and together were calculated . The observed values were reclassified on the basis of these functions . Discrimination (D) in separated groups of men and women using 8 humoral parameters made uncorrect decisions in 18 "i of cases, in the united group uncorrect decisions increased up to 27 %. Similarly, LDF for only 2 groups (EH I, EH II) divided men into stages I and II without any uncorrect decision, meanwhile recognition of stage of EH according to values of individual humoral parameters was associated with many wrong decisions. D in united group showed 28 ^, of wrong decisions. This undirectly supports idea of sex dependent differences, though there was no significant difference between average values of individual parameters in men and women. PGF (EH II only) and CORT were higher and DBH and K (slightly),lower in EH. There were no significant differences between stages of EH with exception of higher PGF and lower CORT in EH II men. D improved when values from 4 places of blood sampling instead of one were used. Na improved D, though no group differred significantly in this parameter. Results sunoort idea that hypertension can be caused by not only absolute, but also relative changes of activity of vasopressor and depressor systems.
88
SUPPLEMENT TO VOL. 27
DISCRIMINATION OF NORMOTENSIVES BY MEANS OF HUMORAL PARAMETERS.
(N) AND
ESSENTIAL
HYPERTENSIVES
PELESKA, J., ZVAROVA, J., KUCEROVA, V., JINDRA, A., SAVLIKOVA, LINHARTOVA, J., ORT, J., JAROLIM, M., RIPKA, 0. 2nd Medical
Department,
Charles
University,
Prague,
(EH)
J.,
Czechoslovakia
Some hypotheses suggest a generalised defect of sodium and potassium transport in cells as the primary factor in the pathogenesis of EH. In 43 men and women belonging to stages I and II of EH (WHO) and 21 N men and women plasma concentrations of prostaglandins E and F (PGE, PGF), aldosterone (ALD), cortisol (CORT), natriurl (Na) potassium (K) plasma renin activity (PRA) and dopamine-beta-hydroxylase activity (DBH) in peripheral venous blood and in blood of renal veins (in EH only) and near to the termination of right suprarenal vein were determined. Linear discriminant functions (LDF) among 3 groups (N, EH I, EH II) for men and women separately and together were calculated . The observed values were reclassified on the basis of these functions . Discrimination (D) in separated groups of men and women using 8 humoral parameters made uncorrect decisions in 18 "i of cases, in the united group uncorrect decisions increased up to 27 %. Similarly, LDF for only 2 groups (EH I, EH II) divided men into stages I and II without any uncorrect decision, meanwhile recognition of stage of EH according to values of individual humoral parameters was associated with many wrong decisions. D in united group showed 28 ^, of wrong decisions. This undirectly supports idea of sex dependent differences, though there was no significant difference between average values of individual parameters in men and women. PGF (EH II only) and CORT were higher and DBH and K (slightly),lower in EH. There were no significant differences between stages of EH with exception of higher PGF and lower CORT in EH II men. D improved when values from 4 places of blood sampling instead of one were used. Na improved D, though no group differred significantly in this parameter. Results sunoort idea that hypertension can be caused by not only absolute, but also relative changes of activity of vasopressor and depressor systems.
88
SUPPLEMENT TO VOL. 27