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Does the rate of weight loss impact on achieving target weight
S38
Oral Abstracts
have completed 8 weeks (i.e., mid-point) of ER. Therefore, these are preliminary data and form part of a larger ongoing study. After 8 weeks of ER both groups lost body weight — however, the INT (9.97 ± 4.3 kg) group lost significantly more than the CONT (4.47 ± 2.0 kg) group (P < 0.01). Despite losing significantly more weight there was a trend for the INT group to experience decreases in fasting hunger (−15%) and average daily hunger (−21%) compared with the CONT group. Further, the CONT group experienced an increase in postprandial hunger after the fixed breakfast, whereas it was reduced in the INT group. The CONT group’s ad libitum food intake increased after 8 weeks of ER and weight loss, but it remained stable for the INT group. These data provide preliminary evidence that a novel intermittent ER intervention could increase weight loss and improve satiety control. NHMRC: 497223.
cessful if they lost 15% of their body weight in their allocated time frame. Results: Of the 120 participants (34 males and 86 females), average age 50 ± 0.9 years, and initial BMI 35.3 ± 0.3 (/kg/m2 ), 60 participants were randomised to the RG, and 60 to the GG. Following intervention, 83.4% of the RG achieved the goal of 15% weight loss compared to 50% in the GG (p < 0.05). Retention rate was greater in the RG (98%) compared to the GG (85%) (p < 0.05). Weight loss was associated with a reduction in fat free mass in both groups but was only significantly lower in the RG (p = 0.04). Participants who saw the dietitian more often were less likely to achieve goal weight. Conclusion: This study has shown that substantial weight loss (15% of initial weight) is more easily achieved if undertaken rapidly. Possible reasons will be discussed. More frequent consultations with a dietitian did not equate with greater weight loss.
doi:10.1016/j.orcp.2010.09.076
doi:10.1016/j.orcp.2010.09.077
O10
O11
Does the rate of weight loss impact on achieving target weight
Pancreatic polypeptide meal response may predict gastric band induced weight loss
K. Purcell 1,∗ , C.J. Bouniu 1 , K. Sumithran 1 , L. Delbridge 1 , L.A. Prendergast 2 , J. Proietto 1 1 University
A.F.R. Dixon 1,∗ , C.W. le Roux 2 , C. Laurie 3 , P.E. O’Brien 3 , M.A. Ghatei 2 , S.R. Bloom 2 , J.B. Dixon 3,4,5
2 La
1 Department
of Melbourne, Melbourne, Australia Trobe University, Melbourne, Australia
Introduction: Very low energy diets (VLEDs) have been used by obese individuals to achieve weight loss for more than 30 years. Despite the positive literature regarding the success of VLEDs, 98.5% of Australian dietitians do not recommend a weight loss of <1 kg a week. This project aims to scientifically investigate this perception. Methods: This was a randomised dietary intervention trial. Baseline testing was performed. Participants were randomised to either: A. Rapid Weight Loss Group (RG)—–participants consumed a commercially available VLCD preparation (Optifast® ) for three months and had bi-weekly contact with a dietitian (approx. 6 appointments in total). B. Gradual Weight Loss Group (GG)—–participants were instructed bi-weekly by a dietitian to achieve a daily negative energy balance of 2000—2500 kJ a day over 9 month period replacing 1 meal with a VLCD (approx. 18 appointments in total). Following the weight-loss intervention (3 or 9 months) participants underwent measurements as per baseline visit. Participants were deemed suc-
of Radiology, Alfred Hospital, Melbourne, Australia 2 Department of Investigative Medicine, Imperial College London, United Kingdom 3 Centre for Obesity Research and Education, Monash University, Melbourne, Australia 4 Baker IDI Heart & Diabetes Institute, Melbourne, Australia 5 Department of General Practice, Monash University, Melbourne, Australia Background: Unknown hormonal and neural satiety signals are thought to drive sustainable weight-loss following Laparoscopic Adjustable Gastric Banding (LAGB). We investigated whether the structurally related satiety hormones Pancreatic Polypeptide (PP) and Peptide YY (PYY) influence total percentage weight-loss following LAGB. Methods: A cross-sectional study examined 17 postoperative individuals who had already achieved mean 28% LAGB induced weight-loss (range 10—38%). A prospective study assessed plasma PP and PYY meal responses in 16 obese individuals prior to LAGB. Results: In the cross-sectional study, individuals with higher weight-loss had lower PP meal responses (2hrAUC, R = −0.65, p = 0.005) and
Oral Abstracts
have completed 8 weeks (i.e., mid-point) of ER. Therefore, these are preliminary data and form part of a larger ongoing study. After 8 weeks of ER both groups lost body weight — however, the INT (9.97 ± 4.3 kg) group lost significantly more than the CONT (4.47 ± 2.0 kg) group (P < 0.01). Despite losing significantly more weight there was a trend for the INT group to experience decreases in fasting hunger (−15%) and average daily hunger (−21%) compared with the CONT group. Further, the CONT group experienced an increase in postprandial hunger after the fixed breakfast, whereas it was reduced in the INT group. The CONT group’s ad libitum food intake increased after 8 weeks of ER and weight loss, but it remained stable for the INT group. These data provide preliminary evidence that a novel intermittent ER intervention could increase weight loss and improve satiety control. NHMRC: 497223.
cessful if they lost 15% of their body weight in their allocated time frame. Results: Of the 120 participants (34 males and 86 females), average age 50 ± 0.9 years, and initial BMI 35.3 ± 0.3 (/kg/m2 ), 60 participants were randomised to the RG, and 60 to the GG. Following intervention, 83.4% of the RG achieved the goal of 15% weight loss compared to 50% in the GG (p < 0.05). Retention rate was greater in the RG (98%) compared to the GG (85%) (p < 0.05). Weight loss was associated with a reduction in fat free mass in both groups but was only significantly lower in the RG (p = 0.04). Participants who saw the dietitian more often were less likely to achieve goal weight. Conclusion: This study has shown that substantial weight loss (15% of initial weight) is more easily achieved if undertaken rapidly. Possible reasons will be discussed. More frequent consultations with a dietitian did not equate with greater weight loss.
doi:10.1016/j.orcp.2010.09.076
doi:10.1016/j.orcp.2010.09.077
O10
O11
Does the rate of weight loss impact on achieving target weight
Pancreatic polypeptide meal response may predict gastric band induced weight loss
K. Purcell 1,∗ , C.J. Bouniu 1 , K. Sumithran 1 , L. Delbridge 1 , L.A. Prendergast 2 , J. Proietto 1 1 University
A.F.R. Dixon 1,∗ , C.W. le Roux 2 , C. Laurie 3 , P.E. O’Brien 3 , M.A. Ghatei 2 , S.R. Bloom 2 , J.B. Dixon 3,4,5
2 La
1 Department
of Melbourne, Melbourne, Australia Trobe University, Melbourne, Australia
Introduction: Very low energy diets (VLEDs) have been used by obese individuals to achieve weight loss for more than 30 years. Despite the positive literature regarding the success of VLEDs, 98.5% of Australian dietitians do not recommend a weight loss of <1 kg a week. This project aims to scientifically investigate this perception. Methods: This was a randomised dietary intervention trial. Baseline testing was performed. Participants were randomised to either: A. Rapid Weight Loss Group (RG)—–participants consumed a commercially available VLCD preparation (Optifast® ) for three months and had bi-weekly contact with a dietitian (approx. 6 appointments in total). B. Gradual Weight Loss Group (GG)—–participants were instructed bi-weekly by a dietitian to achieve a daily negative energy balance of 2000—2500 kJ a day over 9 month period replacing 1 meal with a VLCD (approx. 18 appointments in total). Following the weight-loss intervention (3 or 9 months) participants underwent measurements as per baseline visit. Participants were deemed suc-
of Radiology, Alfred Hospital, Melbourne, Australia 2 Department of Investigative Medicine, Imperial College London, United Kingdom 3 Centre for Obesity Research and Education, Monash University, Melbourne, Australia 4 Baker IDI Heart & Diabetes Institute, Melbourne, Australia 5 Department of General Practice, Monash University, Melbourne, Australia Background: Unknown hormonal and neural satiety signals are thought to drive sustainable weight-loss following Laparoscopic Adjustable Gastric Banding (LAGB). We investigated whether the structurally related satiety hormones Pancreatic Polypeptide (PP) and Peptide YY (PYY) influence total percentage weight-loss following LAGB. Methods: A cross-sectional study examined 17 postoperative individuals who had already achieved mean 28% LAGB induced weight-loss (range 10—38%). A prospective study assessed plasma PP and PYY meal responses in 16 obese individuals prior to LAGB. Results: In the cross-sectional study, individuals with higher weight-loss had lower PP meal responses (2hrAUC, R = −0.65, p = 0.005) and