- Email: [email protected]
Efficacy of monthly and weekly oral bisphosphonates in the treatment of postmenopausal osteoporosis
Abstracts / Bone 47 (2010) S385–S458
the lactating women. The effect of alendronate sodium treatment for post-pregnancy osteoporosis is obvious. doi:10.1016/j.bone.2010.09.316
376 Primary effects of comprehensive lifestyle modification on status of pre-chronic diseases Hua Lin, Qiu-hua Wu, Jian Liu, Xiu-fen Zhu, Yu-mei Shen, Guo-qin Zhang The Center of Research for Metabolic Bone Disease, The Affiliated Drum Tower Hospital of Medical School, Nanjing University, Nanjing, China Objective: To evaluate the effectiveness of comprehensive lifestyle modification in the primary health care system on status of pre-chronic diseases in a conventional healthcare program. Methods: Two hundred and twenty-nine adult volunteers in 5 conventional healthcare centers were divided into 4 groups: group of prehypertension (n= 67), group of prediabetes (n= 38), group of abnormity serum cholesterol (n= 71) and group of osteopenia (n = 53). A multicomponent behavioral intervention including education, physical activity, dietary practice, cease smoking, calcium supplement and exposure to sunlight was conducted for 12 months. The main outcome of each group was blood pressure, blood glucose, serum cholesterol and bone mineral density. Results: Over 12 months, compared with the status before intervention, participants in each group were statistically significantly improved, the mean net reduction in systolic BP/diastolic BP was 9.4 mm Hg/ 6.6 mm Hg (1 mm Hg= 0.133 kPa, t = 5.93/8.29.PPP0.015 g/cm2). Conclusions: For chronic disease prevention, after one year the comprehensive lifestyle intervention produced beneficial changes in diet, physical activity, and biochemical parameters. This type of intervention is a feasible option to prevent chronic disease and should be implemented in the primary health care system. doi:10.1016/j.bone.2010.09.317
377 A comparative study of the treatment on an old osteoporotic fracture patient with acute pain Hua Lin, Xiu-fen Zhu, Xin Chen, Yong-mei Zhang, Wei-guo Li The Center of Research for Metabolic Bone Disease, The Affiliated Drum Tower Hospital of Medical School, Nanjing University, Nanjing, China Objective: To evaluate the effective methods on elderly osteoporotic fracture patient with acute pain by comparing and analyzing the therapeutic effect of calcitonin and pulsed electromagnetic fields. Methods: Ninety-two elderly osteoporotic fracture patients with acute pain were divided into 2 random groups: Calcitonin treatment group (group A), Elcitonin intramuscular 20 U/day: the patients were given treatment once every day for the first week, then twice a week. Lowfrequency pulsed electromagnetic field therapy group (group B), lowfrequency pulsed electromagnetic fields were used: low-frequency, broad width and multifields, one course of treatment lasting four weeks. On first three weeks of every course, the patients were given treatment five times (30 min a time) every week, then rest for one week after fifteen treatments. Every group had a half year of treatment, then we respectively took the evaluation of the algetic strength and catabatic degree before treatment and at the one-month, two-month, four-month and six-month of treatment. Bone mineral density (DXA) and bone strength (QUS), respectively, measured before treatment and at the end of treatment. Results: Low-frequency pulsed electromagnetic fields and Calcitonin had marked anesis effect on the acute pain of elderly osteoporotic fracture patient. Algetic strength obviously
S451
decreased after four weeks (p < 0.01); in the six-month cure process the ache alleviated gradually. Conclusion: The clinical curative effect of calcitonin and the low-frequency pulse electromagnetism field in curing the elderly osteoporotic fracture patient with acute pain was similar, both alleviating the pain effectively.
doi:10.1016/j.bone.2010.09.318
378 Efficacy of monthly and weekly oral bisphosphonates in the treatment of postmenopausal osteoporosis Lihua Bao, Hua Lin, Yongjun Li Nuclear Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China Objective: To estimate the clinical effect and treatment adherence of ibandronate and alendronate in postmenopausal osteoporosis. Methods: This study enrolled 64 postmenopausal women ages 47–80 years with BMD at baseline lumbar spine or femoral neck or total hip T-score≤−2.5. The people were randomly assigned to two groups. Thirty-two in each group: group I, oral ibandronate 150 mg per month; and group II, oral alendronate 70 mg per week. All patients received calcium 500 mg and vitamin D 200 IU daily for one year. All patients were examined by DXA (lumbar and hip) before and after treatment. At the same time, biochemical markers of bone turnover rate were determined. Results: Substantial increases in lumbar spine BMD were seen in group I: 6.25% and 9.64% after half a year and one year of treatment, respectively; those in group II were 6.82% and 11.4%, respectively. There was significance difference in the two groups' comparison with pretreatment (p<0.05). In both groups, the BMD of hip locations also increased but without significance (p>0.05). Serum CTX-1 levels decreased dramatically in both groups. In group I, there were 9.4% of the women who discontinued treatment compared to 21.9% in group II. Conclusions: Once-monthly oral ibandronate is at least as effective as alendronate for increasing bone mineral density and for inhibiting osteoclastic activity in treatment of postmenopausal osteoporosis. Once-monthly administration may be more convenient for patients and improve therapeutic adherence, thereby enhancing therapeutic outcomes.
doi:10.1016/j.bone.2010.09.319
379 Effect of parathyroidectomy and pharmacotherapy in primary hyperthyroidism on bone metabolism Lihua Bao, Hua Lin, Yongjun Lii Nuclear Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China Objective: To evaluate the changes in bone mass and markers of bone metabolism and the clinical manifestations in patients with primary hyperparathyroidism (PHPT) after parathyroidectomy (PTX) and bisphosphonates. Methods: Thirty-six patients with PHPT were randomly assigned to two groups: group I, 25 women after PTX without pharmacotherapy; group II: 11 women after PTX oral alendronate 70 mg per week. Most patients were accompanied by bone pain, skeleton deformity, difficulty in walking, multiple fractures and urinary tract stones. Before and after PTX, half and one year measurements of bone mineral density (BMD) in spine and hip were performed in all patients. Concomitantly, changes in serum intact parathyroid hormone (PTH), alkaline phosphatase (ALP), osteocalin (OC) and serum calcium and phosphrous were assessed. Results: The patients of the two groups
the lactating women. The effect of alendronate sodium treatment for post-pregnancy osteoporosis is obvious. doi:10.1016/j.bone.2010.09.316
376 Primary effects of comprehensive lifestyle modification on status of pre-chronic diseases Hua Lin, Qiu-hua Wu, Jian Liu, Xiu-fen Zhu, Yu-mei Shen, Guo-qin Zhang The Center of Research for Metabolic Bone Disease, The Affiliated Drum Tower Hospital of Medical School, Nanjing University, Nanjing, China Objective: To evaluate the effectiveness of comprehensive lifestyle modification in the primary health care system on status of pre-chronic diseases in a conventional healthcare program. Methods: Two hundred and twenty-nine adult volunteers in 5 conventional healthcare centers were divided into 4 groups: group of prehypertension (n= 67), group of prediabetes (n= 38), group of abnormity serum cholesterol (n= 71) and group of osteopenia (n = 53). A multicomponent behavioral intervention including education, physical activity, dietary practice, cease smoking, calcium supplement and exposure to sunlight was conducted for 12 months. The main outcome of each group was blood pressure, blood glucose, serum cholesterol and bone mineral density. Results: Over 12 months, compared with the status before intervention, participants in each group were statistically significantly improved, the mean net reduction in systolic BP/diastolic BP was 9.4 mm Hg/ 6.6 mm Hg (1 mm Hg= 0.133 kPa, t = 5.93/8.29.PPP0.015 g/cm2). Conclusions: For chronic disease prevention, after one year the comprehensive lifestyle intervention produced beneficial changes in diet, physical activity, and biochemical parameters. This type of intervention is a feasible option to prevent chronic disease and should be implemented in the primary health care system. doi:10.1016/j.bone.2010.09.317
377 A comparative study of the treatment on an old osteoporotic fracture patient with acute pain Hua Lin, Xiu-fen Zhu, Xin Chen, Yong-mei Zhang, Wei-guo Li The Center of Research for Metabolic Bone Disease, The Affiliated Drum Tower Hospital of Medical School, Nanjing University, Nanjing, China Objective: To evaluate the effective methods on elderly osteoporotic fracture patient with acute pain by comparing and analyzing the therapeutic effect of calcitonin and pulsed electromagnetic fields. Methods: Ninety-two elderly osteoporotic fracture patients with acute pain were divided into 2 random groups: Calcitonin treatment group (group A), Elcitonin intramuscular 20 U/day: the patients were given treatment once every day for the first week, then twice a week. Lowfrequency pulsed electromagnetic field therapy group (group B), lowfrequency pulsed electromagnetic fields were used: low-frequency, broad width and multifields, one course of treatment lasting four weeks. On first three weeks of every course, the patients were given treatment five times (30 min a time) every week, then rest for one week after fifteen treatments. Every group had a half year of treatment, then we respectively took the evaluation of the algetic strength and catabatic degree before treatment and at the one-month, two-month, four-month and six-month of treatment. Bone mineral density (DXA) and bone strength (QUS), respectively, measured before treatment and at the end of treatment. Results: Low-frequency pulsed electromagnetic fields and Calcitonin had marked anesis effect on the acute pain of elderly osteoporotic fracture patient. Algetic strength obviously
S451
decreased after four weeks (p < 0.01); in the six-month cure process the ache alleviated gradually. Conclusion: The clinical curative effect of calcitonin and the low-frequency pulse electromagnetism field in curing the elderly osteoporotic fracture patient with acute pain was similar, both alleviating the pain effectively.
doi:10.1016/j.bone.2010.09.318
378 Efficacy of monthly and weekly oral bisphosphonates in the treatment of postmenopausal osteoporosis Lihua Bao, Hua Lin, Yongjun Li Nuclear Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China Objective: To estimate the clinical effect and treatment adherence of ibandronate and alendronate in postmenopausal osteoporosis. Methods: This study enrolled 64 postmenopausal women ages 47–80 years with BMD at baseline lumbar spine or femoral neck or total hip T-score≤−2.5. The people were randomly assigned to two groups. Thirty-two in each group: group I, oral ibandronate 150 mg per month; and group II, oral alendronate 70 mg per week. All patients received calcium 500 mg and vitamin D 200 IU daily for one year. All patients were examined by DXA (lumbar and hip) before and after treatment. At the same time, biochemical markers of bone turnover rate were determined. Results: Substantial increases in lumbar spine BMD were seen in group I: 6.25% and 9.64% after half a year and one year of treatment, respectively; those in group II were 6.82% and 11.4%, respectively. There was significance difference in the two groups' comparison with pretreatment (p<0.05). In both groups, the BMD of hip locations also increased but without significance (p>0.05). Serum CTX-1 levels decreased dramatically in both groups. In group I, there were 9.4% of the women who discontinued treatment compared to 21.9% in group II. Conclusions: Once-monthly oral ibandronate is at least as effective as alendronate for increasing bone mineral density and for inhibiting osteoclastic activity in treatment of postmenopausal osteoporosis. Once-monthly administration may be more convenient for patients and improve therapeutic adherence, thereby enhancing therapeutic outcomes.
doi:10.1016/j.bone.2010.09.319
379 Effect of parathyroidectomy and pharmacotherapy in primary hyperthyroidism on bone metabolism Lihua Bao, Hua Lin, Yongjun Lii Nuclear Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China Objective: To evaluate the changes in bone mass and markers of bone metabolism and the clinical manifestations in patients with primary hyperparathyroidism (PHPT) after parathyroidectomy (PTX) and bisphosphonates. Methods: Thirty-six patients with PHPT were randomly assigned to two groups: group I, 25 women after PTX without pharmacotherapy; group II: 11 women after PTX oral alendronate 70 mg per week. Most patients were accompanied by bone pain, skeleton deformity, difficulty in walking, multiple fractures and urinary tract stones. Before and after PTX, half and one year measurements of bone mineral density (BMD) in spine and hip were performed in all patients. Concomitantly, changes in serum intact parathyroid hormone (PTH), alkaline phosphatase (ALP), osteocalin (OC) and serum calcium and phosphrous were assessed. Results: The patients of the two groups